JP2018506972A5 - - Google Patents
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- JP2018506972A5 JP2018506972A5 JP2017540865A JP2017540865A JP2018506972A5 JP 2018506972 A5 JP2018506972 A5 JP 2018506972A5 JP 2017540865 A JP2017540865 A JP 2017540865A JP 2017540865 A JP2017540865 A JP 2017540865A JP 2018506972 A5 JP2018506972 A5 JP 2018506972A5
- Authority
- JP
- Japan
- Prior art keywords
- peptide
- sequence
- peptide monomer
- monomer
- monomers
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- 239000000178 monomer Substances 0.000 claims 32
- 108090000765 processed proteins & peptides Proteins 0.000 claims 32
- 239000011230 binding agent Substances 0.000 claims 22
- 230000027455 binding Effects 0.000 claims 10
- 208000015181 infectious disease Diseases 0.000 claims 5
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 5
- 241000193163 Clostridioides difficile Species 0.000 claims 4
- 230000003472 neutralizing effect Effects 0.000 claims 4
- 239000003053 toxin Substances 0.000 claims 4
- 231100000765 toxin Toxicity 0.000 claims 4
- 108700012359 toxins Proteins 0.000 claims 4
- 125000003275 alpha amino acid group Chemical group 0.000 claims 3
- 239000000825 pharmaceutical preparation Substances 0.000 claims 3
- 101710084578 Short neurotoxin 1 Proteins 0.000 claims 2
- 101710182223 Toxin B Proteins 0.000 claims 2
- 101710182532 Toxin a Proteins 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 238000006386 neutralization reaction Methods 0.000 claims 2
- 102000005927 Cysteine Proteases Human genes 0.000 claims 1
- 108010005843 Cysteine Proteases Proteins 0.000 claims 1
- 102000051366 Glycosyltransferases Human genes 0.000 claims 1
- 108700023372 Glycosyltransferases Proteins 0.000 claims 1
- 239000000539 dimer Substances 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 108020003175 receptors Proteins 0.000 claims 1
- 102000005962 receptors Human genes 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 230000024033 toxin binding Effects 0.000 claims 1
- 230000005945 translocation Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562113046P | 2015-02-06 | 2015-02-06 | |
| US62/113,046 | 2015-02-06 | ||
| PCT/US2016/016852 WO2016127104A2 (en) | 2015-02-06 | 2016-02-05 | Tetra-specific, octameric binding agents and antibodies against clostridium difficile toxin a and toxin b for treatment of c. difficile infection |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019233702A Division JP2020072685A (ja) | 2015-02-06 | 2019-12-25 | クロストリジウム・ディフィシル感染症の治療のための、クロストリジウム・ディフィシルのトキシンａ及びトキシンｂに対する四重特異性の八量体型結合剤及び抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018506972A JP2018506972A (ja) | 2018-03-15 |
| JP2018506972A5 true JP2018506972A5 (https=) | 2019-03-22 |
| JP6640232B2 JP6640232B2 (ja) | 2020-02-05 |
Family
ID=56564887
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017540865A Active JP6640232B2 (ja) | 2015-02-06 | 2016-02-05 | クロストリジウム・ディフィシル感染症の治療のための、クロストリジウム・ディフィシルのトキシンａ及びトキシンｂに対する四重特異性の八量体型結合剤及び抗体 |
| JP2019233702A Withdrawn JP2020072685A (ja) | 2015-02-06 | 2019-12-25 | クロストリジウム・ディフィシル感染症の治療のための、クロストリジウム・ディフィシルのトキシンａ及びトキシンｂに対する四重特異性の八量体型結合剤及び抗体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019233702A Withdrawn JP2020072685A (ja) | 2015-02-06 | 2019-12-25 | クロストリジウム・ディフィシル感染症の治療のための、クロストリジウム・ディフィシルのトキシンａ及びトキシンｂに対する四重特異性の八量体型結合剤及び抗体 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US10961299B2 (https=) |
| EP (1) | EP3253790A4 (https=) |
| JP (2) | JP6640232B2 (https=) |
| AU (1) | AU2016215087A1 (https=) |
| CA (1) | CA2974720A1 (https=) |
| WO (1) | WO2016127104A2 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10676723B2 (en) | 2015-05-11 | 2020-06-09 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| JP7184336B2 (ja) | 2015-10-13 | 2022-12-06 | ザ ユニバーシティ オブ メリーランド，ボルチモア | クロストリジウム・ディフィシル感染症に対する酵母ベースの免疫療法 |
| US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| US20200157224A1 (en) * | 2017-06-25 | 2020-05-21 | Systimmune, Inc. | Multi-specific antibodies and methods of making and using thereof |
| KR102763369B1 (ko) * | 2017-06-25 | 2025-02-05 | 시스트이뮨, 인코포레이티드 | 다중-특이적 항체 및 이를 제조하는 방법 및 이의 용도 |
| AU2020287324A1 (en) * | 2019-06-03 | 2022-01-20 | Fzata, Inc. | Humanized tetra-specific octavalent antibody against Clostridium difficile toxin A and B |
| CA3193741A1 (en) * | 2020-09-02 | 2022-03-10 | The Regents Of The University Of California | A broadly neutralizing molecule against clostridium difficile toxin b |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2006323412A1 (en) * | 2005-12-06 | 2007-06-14 | Domantis Limited | Ligands that have binding specificity for EGFR and/or VEGF and methods of use therefor |
| US9023352B2 (en) * | 2007-02-20 | 2015-05-05 | Tufts University | Methods, compositions and kits for treating a subject using a recombinant heteromultimeric neutralizing binding protein |
| US20160031971A9 (en) * | 2007-02-20 | 2016-02-04 | Tufts University | Methods and compositions with a recombinant neutralizing binding protein for treating toxin exposure |
| KR20100052545A (ko) | 2007-08-28 | 2010-05-19 | 바이오겐 아이덱 엠에이 인코포레이티드 | Ｉｇｆ―１ｒ의 다중 에피토프에 결합하는 조성물 |
| NZ601117A (en) | 2010-03-03 | 2014-06-27 | Boehringer Ingelheim Int | Biparatopic abeta binding polypeptides |
| US8702942B2 (en) | 2010-12-17 | 2014-04-22 | Malvern Instruments, Ltd. | Laser doppler electrophoresis using a diffusion barrier |
| EP2961770A1 (en) | 2013-02-26 | 2016-01-06 | Roche Glycart AG | Bispecific t cell activating antigen binding molecules |
| US11634502B2 (en) * | 2013-03-15 | 2023-04-25 | Amgen Inc. | Heterodimeric bispecific antibodies |
| JP7184336B2 (ja) * | 2015-10-13 | 2022-12-06 | ザ ユニバーシティ オブ メリーランド，ボルチモア | クロストリジウム・ディフィシル感染症に対する酵母ベースの免疫療法 |
-
2016
- 2016-02-05 EP EP16747370.1A patent/EP3253790A4/en not_active Withdrawn
- 2016-02-05 AU AU2016215087A patent/AU2016215087A1/en not_active Abandoned
- 2016-02-05 JP JP2017540865A patent/JP6640232B2/ja active Active
- 2016-02-05 US US15/548,901 patent/US10961299B2/en active Active
- 2016-02-05 CA CA2974720A patent/CA2974720A1/en not_active Abandoned
- 2016-02-05 WO PCT/US2016/016852 patent/WO2016127104A2/en not_active Ceased
-
2019
- 2019-12-25 JP JP2019233702A patent/JP2020072685A/ja not_active Withdrawn
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