JP2018505228A5 - - Google Patents
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- Publication number
- JP2018505228A5 JP2018505228A5 JP2017561611A JP2017561611A JP2018505228A5 JP 2018505228 A5 JP2018505228 A5 JP 2018505228A5 JP 2017561611 A JP2017561611 A JP 2017561611A JP 2017561611 A JP2017561611 A JP 2017561611A JP 2018505228 A5 JP2018505228 A5 JP 2018505228A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- aryl
- optionally substituted
- cycloalkyl
- heteroaryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562117205P | 2015-02-17 | 2015-02-17 | |
| US62/117,205 | 2015-02-17 | ||
| PCT/US2016/018233 WO2016133995A1 (en) | 2015-02-17 | 2016-02-17 | Phenothiazine analogues as mitochondrial therapeutic agents |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020169793A Division JP7113055B2 (ja) | 2015-02-17 | 2020-10-07 | ミトコンドリア治療剤としてのフェノチアジン類似体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018505228A JP2018505228A (ja) | 2018-02-22 |
| JP2018505228A5 true JP2018505228A5 (https=) | 2020-04-09 |
| JP6807337B2 JP6807337B2 (ja) | 2021-01-06 |
Family
ID=56692740
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017561611A Expired - Fee Related JP6807337B2 (ja) | 2015-02-17 | 2016-02-17 | ミトコンドリア治療剤としてのフェノチアジン類似体 |
| JP2020169793A Expired - Fee Related JP7113055B2 (ja) | 2015-02-17 | 2020-10-07 | ミトコンドリア治療剤としてのフェノチアジン類似体 |
| JP2022118006A Pending JP2022141896A (ja) | 2015-02-17 | 2022-07-25 | ミトコンドリア治療剤としてのフェノチアジン類似体 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020169793A Expired - Fee Related JP7113055B2 (ja) | 2015-02-17 | 2020-10-07 | ミトコンドリア治療剤としてのフェノチアジン類似体 |
| JP2022118006A Pending JP2022141896A (ja) | 2015-02-17 | 2022-07-25 | ミトコンドリア治療剤としてのフェノチアジン類似体 |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US10472340B2 (https=) |
| EP (1) | EP3258938B1 (https=) |
| JP (3) | JP6807337B2 (https=) |
| AU (3) | AU2016220096B2 (https=) |
| CA (1) | CA2976776C (https=) |
| DK (1) | DK3258938T3 (https=) |
| WO (1) | WO2016133995A1 (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016133995A1 (en) | 2015-02-17 | 2016-08-25 | Arizona Board Of Regents On Behalf Of Arizona State University | Phenothiazine analogues as mitochondrial therapeutic agents |
| US10364227B2 (en) | 2015-02-17 | 2019-07-30 | Arizona Board Of Regents On Behalf Of Arizona State University | Therapeutic compounds |
| US10604501B2 (en) | 2016-06-15 | 2020-03-31 | Arizona Board Of Regents On Behalf Of Arizona State University | Prodrug and profluorescent compounds for selective mitochondrial imaging and therapeutic targeting |
| US11390605B2 (en) | 2016-08-25 | 2022-07-19 | Arizona Board Of Regents On Behalf Of Arizona State University | Substituted pyrimidine compounds as multifunctional radical quenchers and their uses |
| WO2018039487A1 (en) | 2016-08-25 | 2018-03-01 | Arizona Board Of Regents On Behalf Of Arizona State University | Therapeutic compounds |
| US12570622B2 (en) | 2016-08-25 | 2026-03-10 | Arizona Board Of Regents On Behalf Of Arizona State University | Therapeutic compounds |
| WO2018129411A1 (en) * | 2017-01-06 | 2018-07-12 | Bioelectron Technology Corporation | Aryl- and heteroaryl-resorufin derivatives for treatment of oxidative stress disorders and liver and kidney disorders |
| FR3063495B1 (fr) * | 2017-03-02 | 2019-04-05 | Provepharm Life Solutions | Procede de preparation de l’iodure de 3,7-bis(dimethylamino)phenothiazine-5-ylium |
| CN108484527B (zh) * | 2018-04-27 | 2022-01-14 | 成都恒昊创新科技有限公司 | 一种10h-吩噻嗪类铁死亡抑制剂及其制备方法与应用 |
| WO2020021536A1 (en) | 2018-07-22 | 2020-01-30 | Minovia Therapeutics Ltd. | Mitochondrial augmentation therapy for primary mitochondrial diseases |
| DK3826639T3 (da) * | 2018-07-26 | 2024-09-23 | Wista Lab Ltd | Optimeret dosering af diaminophenothiaziner i populationer |
| US12110313B2 (en) | 2019-02-28 | 2024-10-08 | Arizona Board Of Regents On Behalf Of Arizona State University | Engineered bacterial ribosome compositions and methods |
| WO2022171265A1 (en) * | 2021-02-09 | 2022-08-18 | Boehringer Ingelheim International Gmbh | Modulators of complex i |
| CN119504646A (zh) * | 2024-11-07 | 2025-02-25 | 长春工业大学 | 新型含有吩噻嗪结构药物小分子的合成及抗肿瘤活性研究 |
Family Cites Families (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3476722A (en) | 1966-08-15 | 1969-11-04 | Goodrich Co B F | Process for polymerizing acrylic acid esters |
| DE2315349A1 (de) | 1973-03-28 | 1974-10-03 | Bayer Ag | Nicht verfaerbende alterungsschutzmittel |
| JPS5168569A (en) | 1974-12-10 | 1976-06-14 | Fuji Photo Film Co Ltd | 2 2 44 torimechiru 66 hidorokishi 77 chikankuromanruino seizoho |
| FR2471052B1 (fr) | 1979-11-28 | 1985-10-11 | Kuraray Co | Photo-electrode pour cellule photo-electrochimique et son procede de fabrication |
| US4559157A (en) | 1983-04-21 | 1985-12-17 | Creative Products Resource Associates, Ltd. | Cosmetic applicator useful for skin moisturizing |
| LU84979A1 (fr) | 1983-08-30 | 1985-04-24 | Oreal | Composition cosmetique ou pharmaceutique sous forme aqueuse ou anhydre dont la phase grasse contient un polyether oligomere et polyethers oligomeres nouveaux |
| US5220042A (en) | 1984-01-26 | 1993-06-15 | Otsuka Pharmaceutical Co., Ltd. | 1,4-benzoquinone derivatives and benzene derivatives, and process for preparing the same |
| US4820508A (en) | 1987-06-23 | 1989-04-11 | Neutrogena Corporation | Skin protective composition |
| US4992478A (en) | 1988-04-04 | 1991-02-12 | Warner-Lambert Company | Antiinflammatory skin moisturizing composition and method of preparing same |
| US4938949A (en) | 1988-09-12 | 1990-07-03 | University Of New York | Treatment of damaged bone marrow and dosage units therefor |
| CA2099868C (en) | 1991-01-31 | 2002-04-02 | Thomas Richard Belliotti | Substituted 4,6-di-tertiary-butyl-5-hydroxy-pyrimidines |
| WO1996031217A1 (en) | 1995-04-04 | 1996-10-10 | Duke University | Inhibiting retroviral replication |
| JP2001209176A (ja) | 1999-04-02 | 2001-08-03 | Fuji Photo Film Co Ltd | 光重合性組成物およびそれを用いた記録材料 |
| JP4064671B2 (ja) | 2000-02-25 | 2008-03-19 | エフ．ホフマン−ラ ロシュ アーゲー | アデノシン受容体モジュレーター |
| WO2002000683A2 (en) | 2000-06-23 | 2002-01-03 | Vanderbilt University | Novel chain-breaking antioxidants |
| AU2002319583B2 (en) | 2001-07-20 | 2005-08-25 | Eli Lilly And Company | (Pyridinyl and pyrimidyl) trienoic acid derivatives as retinoid X receptor modulators |
| MXPA04012559A (es) | 2002-06-17 | 2005-09-21 | Verification Technologies Inc | Materiales para proteccion contra copias de medio optico que reacciona transitoriamente a un haz de lector. |
| CA2505603A1 (en) | 2002-11-18 | 2004-06-03 | Genospectra, Inc. | Caged sensors, regulators and compounds and uses thereof |
| US20060188866A1 (en) | 2005-02-18 | 2006-08-24 | Children's Hospital Oakland Research Institute | Diaminophenothiazine compositions and uses thereof |
| EP1863796A1 (en) | 2005-03-22 | 2007-12-12 | NeuroSearch A/S | Pyrazolyl-pyrimidines as potassium channel modulating agents and their medical use |
| DK3121169T3 (da) | 2006-07-11 | 2022-02-28 | Wista Lab Ltd | Fremgangsmåder til syntese og/eller oprensning af diaminophenothiaziniumforbindelser |
| CN101820884B (zh) * | 2007-06-19 | 2013-08-28 | 维斯塔实验室有限公司 | 用于治疗轻度认知缺损的吩噻嗪化合物 |
| US8268849B2 (en) | 2007-09-25 | 2012-09-18 | Board Of Regents Of The University Of Nebraska | Multifunctional Antioxidants and methods of use thereof |
| EP2268311A4 (en) | 2008-04-04 | 2014-08-27 | Immunolight Llc | NON-INVASIVE SYSTEMS AND IN SITU PHOTOBIOMODULATION METHODS |
| US8389583B2 (en) | 2008-05-23 | 2013-03-05 | Zurex Pharma, Inc. | Antimicrobial compositions and methods of use |
| CA2784830C (en) | 2009-12-18 | 2018-03-27 | Sunovion Pharmaceuticals Inc. | Compounds for treating disorders mediated by metabotropic glutamate receptor 5, and methods of use thereof |
| ES2687177T3 (es) | 2010-02-19 | 2018-10-24 | Arizona Board Of Regents, A body corporate of the State of Arizona acting, For and on behalf of Arizona State University | Inhibidores de radicales multifuncionales y su uso |
| CN102958525B (zh) * | 2010-04-30 | 2017-05-24 | 普罗瑟塔抗病毒股份有限公司 | 抗病毒化合物 |
| WO2012022467A2 (en) | 2010-08-16 | 2012-02-23 | Santhera Pharmaceuticals (Schweiz) Ag | Novel benzoquinone derivatives and use thereof as modulators of mitochondrial function |
| DE102010043379A1 (de) | 2010-11-04 | 2012-05-10 | Bayer Schering Pharma Aktiengesellschaft | Substituierte 6-Fluor-1H-Pyrazolo[4,3-b]pyridine und ihre Verwendung |
| EP2450893A1 (de) * | 2010-11-08 | 2012-05-09 | Bayer MaterialScience AG | Photopolymer-Formulierung zur Herstellung holographischer Medien mit hoch vernetzten Matrixpolymeren |
| WO2012125983A1 (en) | 2011-03-17 | 2012-09-20 | Prosetta Antiviral Inc. | Antiviral treatments |
| CA2830581A1 (en) | 2011-04-04 | 2012-10-11 | Arizona Board Of Regents, A Body Corporate Of The State Of Arizona, Acting For And On Behalf Of Arizona State University | Multifunctional radical quenchers for the treatment of mitochondrial dysfunction |
| KR101270160B1 (ko) | 2011-05-16 | 2013-05-31 | 아주대학교산학협력단 | 가변색 이광자 형광프로브, 이를 이용한 미토콘드리아 내 티올 활성의 영상화 방법 및 이의 제조방법 |
| US9440967B2 (en) | 2012-02-10 | 2016-09-13 | Arizona Board Of Regents On Behalf Of Arizona State University | 1H-pyrrolo [2, 3 -B] pyridine derivatives and their use as radical quenchers |
| WO2013120040A1 (en) | 2012-02-10 | 2013-08-15 | Children's Medical Center Corporation | Targeted pathway inhibition to improve muscle structure, function and activity in muscular dystrophy |
| US9334250B2 (en) | 2012-10-03 | 2016-05-10 | Arizona Board Of Regents, A Body Corporate Of The State Of Arizona Acting For And On Behalf Of Arizona State University | Multifunctional radical quenchers for the treatment of mitochondrial dysfunction |
| JP2016501832A (ja) | 2012-10-10 | 2016-01-21 | アリゾナ ボード オブ リージェンツ オン ビハーフ オブ アリゾナ ステート ユニバーシティ | 多機能ラジカル消光剤 |
| US20140275045A1 (en) | 2013-03-15 | 2014-09-18 | Edison Pharmaceuticals, Inc. | Phenazine-3-one and phenothiazine-3-one derivatives for treatment of oxidative stress disorders |
| US10364227B2 (en) | 2015-02-17 | 2019-07-30 | Arizona Board Of Regents On Behalf Of Arizona State University | Therapeutic compounds |
| WO2016133995A1 (en) | 2015-02-17 | 2016-08-25 | Arizona Board Of Regents On Behalf Of Arizona State University | Phenothiazine analogues as mitochondrial therapeutic agents |
| US10604501B2 (en) | 2016-06-15 | 2020-03-31 | Arizona Board Of Regents On Behalf Of Arizona State University | Prodrug and profluorescent compounds for selective mitochondrial imaging and therapeutic targeting |
| US11390605B2 (en) | 2016-08-25 | 2022-07-19 | Arizona Board Of Regents On Behalf Of Arizona State University | Substituted pyrimidine compounds as multifunctional radical quenchers and their uses |
| WO2018039487A1 (en) | 2016-08-25 | 2018-03-01 | Arizona Board Of Regents On Behalf Of Arizona State University | Therapeutic compounds |
-
2016
- 2016-02-17 WO PCT/US2016/018233 patent/WO2016133995A1/en not_active Ceased
- 2016-02-17 EP EP16752964.3A patent/EP3258938B1/en active Active
- 2016-02-17 CA CA2976776A patent/CA2976776C/en active Active
- 2016-02-17 AU AU2016220096A patent/AU2016220096B2/en active Active
- 2016-02-17 DK DK16752964.3T patent/DK3258938T3/da active
- 2016-02-17 JP JP2017561611A patent/JP6807337B2/ja not_active Expired - Fee Related
- 2016-02-17 US US15/550,282 patent/US10472340B2/en active Active
-
2019
- 2019-10-21 US US16/659,308 patent/US11034662B2/en active Active
-
2020
- 2020-04-29 AU AU2020202836A patent/AU2020202836B2/en not_active Ceased
- 2020-10-07 JP JP2020169793A patent/JP7113055B2/ja not_active Expired - Fee Related
-
2021
- 2021-02-22 AU AU2021201137A patent/AU2021201137A1/en not_active Abandoned
- 2021-04-28 US US17/243,005 patent/US20220081404A1/en not_active Abandoned
-
2022
- 2022-07-25 JP JP2022118006A patent/JP2022141896A/ja active Pending
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