JP2018504141A - 非標的化アデノウイルス変異体および関連する方法 - Google Patents
非標的化アデノウイルス変異体および関連する方法 Download PDFInfo
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- JP2018504141A JP2018504141A JP2017556782A JP2017556782A JP2018504141A JP 2018504141 A JP2018504141 A JP 2018504141A JP 2017556782 A JP2017556782 A JP 2017556782A JP 2017556782 A JP2017556782 A JP 2017556782A JP 2018504141 A JP2018504141 A JP 2018504141A
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- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/76—Viruses; Subviral particles; Bacteriophages
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- A61K35/66—Microorganisms or materials therefrom
- A61K35/76—Viruses; Subviral particles; Bacteriophages
- A61K35/761—Adenovirus
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- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
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- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
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- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
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- C12N2810/00—Vectors comprising a targeting moiety
- C12N2810/40—Vectors comprising a peptide as targeting moiety, e.g. a synthetic peptide, from undefined source
- C12N2810/405—Vectors comprising RGD peptide
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- Medicinal Chemistry (AREA)
- Wood Science & Technology (AREA)
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- Animal Behavior & Ethology (AREA)
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- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562105284P | 2015-01-20 | 2015-01-20 | |
| US62/105,284 | 2015-01-20 | ||
| PCT/US2016/013765 WO2016118433A1 (en) | 2015-01-20 | 2016-01-17 | Detargeted adenovirus variants and related methods |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018504141A true JP2018504141A (ja) | 2018-02-15 |
| JP2018504141A5 JP2018504141A5 (enExample) | 2019-02-07 |
Family
ID=56417617
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017556782A Pending JP2018504141A (ja) | 2015-01-20 | 2016-01-17 | 非標的化アデノウイルス変異体および関連する方法 |
Country Status (4)
| Country | Link |
|---|---|
| US (3) | US10376549B2 (enExample) |
| EP (1) | EP3247807B1 (enExample) |
| JP (1) | JP2018504141A (enExample) |
| WO (1) | WO2016118433A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102089121B1 (ko) | 2013-03-14 | 2020-03-13 | 더 솔크 인스티튜트 포 바이올로지칼 스터디즈 | 종양살상형 아데노바이러스 조성물 |
| CN117384961A (zh) | 2016-02-23 | 2024-01-12 | 萨克生物研究学院 | 对病毒动力学影响最小的治疗性腺病毒中的外源基因表达 |
| AU2017222568B2 (en) | 2016-02-23 | 2020-09-10 | Salk Institute For Biological Studies | High throughput assay for measuring adenovirus replication kinetics |
| CN117534735A (zh) * | 2016-03-31 | 2024-02-09 | 欧洲分子生物学实验室 | 腺病毒外壳蛋白衍生递送载体 |
| WO2018111767A1 (en) | 2016-12-12 | 2018-06-21 | Salk Institute For Biological Studies | Tumor-targeting synthetic adenoviruses and uses thereof |
| GB201802539D0 (en) * | 2018-02-16 | 2018-04-04 | Univ College Cardiff Consultants Ltd | Modified adenoviruses |
| MX2020010499A (es) | 2018-04-09 | 2020-10-28 | Salk Inst For Biological Studi | Composiciones de adenovirus oncoliticas con propiedades aumentadas de replicacion. |
| EP3812465A1 (en) * | 2019-10-21 | 2021-04-28 | Universität Ulm | Adenovirus comprising a modified adenovirus hexon protein |
Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH06508603A (ja) * | 1991-02-14 | 1994-09-29 | ラ ホヤ キャンサー リサーチ ファウンデーション | HIV Tatタンパク質に対する新規インテグリン特異性 |
| JP2002525065A (ja) * | 1998-09-11 | 2002-08-13 | ジェンベク、インコーポレイティッド | 選択的にターゲッティングされるアデノウイルス |
| WO2002081497A2 (en) * | 2001-04-04 | 2002-10-17 | University Of Rochester | αξβ3 INTEGRIN-BINDING POLYPEPTIDE MONOBODIES AND THEIR USE |
| JP2004290018A (ja) * | 2003-03-25 | 2004-10-21 | Kokuritsu Iyakuhin Shokuhin Eisei Kenkyusho | 変異型アデノウイルスベクター |
| JP2005503823A (ja) * | 2001-09-29 | 2005-02-10 | ヨンセイ ユニバーシティ | 改善された疾患治療効果を有する組換えアデノウィルス及びそれを含む薬剤学的組成物 |
| US20060281090A1 (en) * | 2003-05-01 | 2006-12-14 | University Of Washington Uw Tech Transfer- Invention Licensing | Capsid-modified adenovirus vectors and methods of using the same |
| JP2009034109A (ja) * | 2002-01-24 | 2009-02-19 | Scripps Research Inst | 効率的なターゲッティングのためのファィバーシャフト修飾 |
| US20110104788A1 (en) * | 2008-02-07 | 2011-05-05 | Andrew Baker | Modulation of Adenoviral Tropism |
| US20110189234A1 (en) * | 2006-02-13 | 2011-08-04 | Van Beusechem Victor Willem | Adenovirus particles having a chimeric adenovirus spike protein, use thereof and methods for producing such particles |
| JP2013509887A (ja) * | 2009-11-09 | 2013-03-21 | ジェンヴェック,インコーポレーテッド | サルアデノウイルスベクターの増殖方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1601438A (enExample) | 1968-10-17 | 1970-08-24 | ||
| US5559099A (en) | 1994-09-08 | 1996-09-24 | Genvec, Inc. | Penton base protein and methods of using same |
| US20060057553A1 (en) * | 2000-05-30 | 2006-03-16 | Estuardo Aguilar-Cordova | Chimeric viral vectors for gene therapy |
-
2016
- 2016-01-17 JP JP2017556782A patent/JP2018504141A/ja active Pending
- 2016-01-17 WO PCT/US2016/013765 patent/WO2016118433A1/en not_active Ceased
- 2016-01-17 US US15/537,392 patent/US10376549B2/en active Active
- 2016-01-17 EP EP16740545.5A patent/EP3247807B1/en not_active Not-in-force
-
2019
- 2019-07-02 US US16/460,160 patent/US11364306B2/en active Active
-
2022
- 2022-06-07 US US17/805,825 patent/US20230001014A1/en not_active Abandoned
Patent Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH06508603A (ja) * | 1991-02-14 | 1994-09-29 | ラ ホヤ キャンサー リサーチ ファウンデーション | HIV Tatタンパク質に対する新規インテグリン特異性 |
| JP2002525065A (ja) * | 1998-09-11 | 2002-08-13 | ジェンベク、インコーポレイティッド | 選択的にターゲッティングされるアデノウイルス |
| WO2002081497A2 (en) * | 2001-04-04 | 2002-10-17 | University Of Rochester | αξβ3 INTEGRIN-BINDING POLYPEPTIDE MONOBODIES AND THEIR USE |
| JP2005503823A (ja) * | 2001-09-29 | 2005-02-10 | ヨンセイ ユニバーシティ | 改善された疾患治療効果を有する組換えアデノウィルス及びそれを含む薬剤学的組成物 |
| JP2009034109A (ja) * | 2002-01-24 | 2009-02-19 | Scripps Research Inst | 効率的なターゲッティングのためのファィバーシャフト修飾 |
| JP2004290018A (ja) * | 2003-03-25 | 2004-10-21 | Kokuritsu Iyakuhin Shokuhin Eisei Kenkyusho | 変異型アデノウイルスベクター |
| US20060281090A1 (en) * | 2003-05-01 | 2006-12-14 | University Of Washington Uw Tech Transfer- Invention Licensing | Capsid-modified adenovirus vectors and methods of using the same |
| US20110189234A1 (en) * | 2006-02-13 | 2011-08-04 | Van Beusechem Victor Willem | Adenovirus particles having a chimeric adenovirus spike protein, use thereof and methods for producing such particles |
| US20110104788A1 (en) * | 2008-02-07 | 2011-05-05 | Andrew Baker | Modulation of Adenoviral Tropism |
| JP2013509887A (ja) * | 2009-11-09 | 2013-03-21 | ジェンヴェック,インコーポレーテッド | サルアデノウイルスベクターの増殖方法 |
Non-Patent Citations (2)
| Title |
|---|
| BRADSHAW, A.C. ET AL: "Biodistribution and inflammatory profiles of novel penton and hexon double-mutant serotype 5 adenovi", JOURNAL OF CONTROLLED RELEASE, vol. 164, JPN6019042745, 2012, pages 394 - 402, ISSN: 0004274033 * |
| KHARE, R. ET AL: "Identification of Adenovirus Serotype 5 Hexon Regions That Interact with Scavenger Receptors", JOURNAL OF VIROLOGY, JPN6019042746, 2011, pages 2293 - 2301, ISSN: 0004274034 * |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2016118433A1 (en) | 2016-07-28 |
| US20190388487A1 (en) | 2019-12-26 |
| US11364306B2 (en) | 2022-06-21 |
| US10376549B2 (en) | 2019-08-13 |
| EP3247807B1 (en) | 2020-12-16 |
| EP3247807A4 (en) | 2018-06-13 |
| EP3247807A1 (en) | 2017-11-29 |
| US20230001014A1 (en) | 2023-01-05 |
| US20180099015A1 (en) | 2018-04-12 |
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