JP2018502922A5 - - Google Patents
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- JP2018502922A5 JP2018502922A5 JP2017555422A JP2017555422A JP2018502922A5 JP 2018502922 A5 JP2018502922 A5 JP 2018502922A5 JP 2017555422 A JP2017555422 A JP 2017555422A JP 2017555422 A JP2017555422 A JP 2017555422A JP 2018502922 A5 JP2018502922 A5 JP 2018502922A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- ebola virus
- vector
- virus antigen
- adenovirus type
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000203 mixture Substances 0.000 claims 21
- 241001115402 Ebolavirus Species 0.000 claims 16
- 239000000427 antigen Substances 0.000 claims 16
- 102000036639 antigens Human genes 0.000 claims 16
- 108091007433 antigens Proteins 0.000 claims 16
- 241001135569 Human adenovirus 5 Species 0.000 claims 10
- 108090000288 Glycoproteins Proteins 0.000 claims 8
- 102000003886 Glycoproteins Human genes 0.000 claims 8
- 150000007523 nucleic acids Chemical group 0.000 claims 6
- 102100021592 Interleukin-7 Human genes 0.000 claims 5
- 108010002586 Interleukin-7 Proteins 0.000 claims 5
- 230000002163 immunogen Effects 0.000 claims 5
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 4
- 230000028993 immune response Effects 0.000 claims 4
- 230000002950 deficient Effects 0.000 claims 3
- 238000012217 deletion Methods 0.000 claims 3
- 230000037430 deletion Effects 0.000 claims 3
- 230000008088 immune pathway Effects 0.000 claims 3
- 230000010076 replication Effects 0.000 claims 3
- 102100029822 B- and T-lymphocyte attenuator Human genes 0.000 claims 2
- 241000884921 Bundibugyo ebolavirus Species 0.000 claims 2
- 102100038078 CD276 antigen Human genes 0.000 claims 2
- -1 CD86 Proteins 0.000 claims 2
- 101000834898 Homo sapiens Alpha-synuclein Proteins 0.000 claims 2
- 101000864344 Homo sapiens B- and T-lymphocyte attenuator Proteins 0.000 claims 2
- 101001137987 Homo sapiens Lymphocyte activation gene 3 protein Proteins 0.000 claims 2
- 101000611936 Homo sapiens Programmed cell death protein 1 Proteins 0.000 claims 2
- 101000652359 Homo sapiens Spermatogenesis-associated protein 2 Proteins 0.000 claims 2
- 102100037850 Interferon gamma Human genes 0.000 claims 2
- 108010074328 Interferon-gamma Proteins 0.000 claims 2
- 102000000588 Interleukin-2 Human genes 0.000 claims 2
- 108010002350 Interleukin-2 Proteins 0.000 claims 2
- 102000017578 LAG3 Human genes 0.000 claims 2
- 102100040678 Programmed cell death protein 1 Human genes 0.000 claims 2
- 241001115394 Reston ebolavirus Species 0.000 claims 2
- 241001115376 Sudan ebolavirus Species 0.000 claims 2
- 230000024932 T cell mediated immunity Effects 0.000 claims 2
- 241001115374 Tai Forest ebolavirus Species 0.000 claims 2
- 102100038929 V-set domain-containing T-cell activation inhibitor 1 Human genes 0.000 claims 2
- 101150010086 VP24 gene Proteins 0.000 claims 2
- 101150026858 VP30 gene Proteins 0.000 claims 2
- 101150077651 VP35 gene Proteins 0.000 claims 2
- 101150036892 VP40 gene Proteins 0.000 claims 2
- 241001115400 Zaire ebolavirus Species 0.000 claims 2
- OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 claims 2
- 230000008350 antigen-specific antibody response Effects 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 230000004927 fusion Effects 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 230000028327 secretion Effects 0.000 claims 2
- 239000002126 C01EB10 - Adenosine Substances 0.000 claims 1
- 102100027207 CD27 antigen Human genes 0.000 claims 1
- 108010029697 CD40 Ligand Proteins 0.000 claims 1
- 101150013553 CD40 gene Proteins 0.000 claims 1
- 102100032937 CD40 ligand Human genes 0.000 claims 1
- 102100025221 CD70 antigen Human genes 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 102100039498 Cytotoxic T-lymphocyte protein 4 Human genes 0.000 claims 1
- 102100037840 Dehydrogenase/reductase SDR family member 2, mitochondrial Human genes 0.000 claims 1
- 101150029662 E1 gene Proteins 0.000 claims 1
- 101150005585 E3 gene Proteins 0.000 claims 1
- 101150066038 E4 gene Proteins 0.000 claims 1
- 238000011510 Elispot assay Methods 0.000 claims 1
- 102100031351 Galectin-9 Human genes 0.000 claims 1
- 101100229077 Gallus gallus GAL9 gene Proteins 0.000 claims 1
- 102100034458 Hepatitis A virus cellular receptor 2 Human genes 0.000 claims 1
- 101000914511 Homo sapiens CD27 antigen Proteins 0.000 claims 1
- 101000934356 Homo sapiens CD70 antigen Proteins 0.000 claims 1
- 101000889276 Homo sapiens Cytotoxic T-lymphocyte protein 4 Proteins 0.000 claims 1
- 101001068133 Homo sapiens Hepatitis A virus cellular receptor 2 Proteins 0.000 claims 1
- 101001019455 Homo sapiens ICOS ligand Proteins 0.000 claims 1
- 101001117317 Homo sapiens Programmed cell death 1 ligand 1 Proteins 0.000 claims 1
- 101001117312 Homo sapiens Programmed cell death 1 ligand 2 Proteins 0.000 claims 1
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims 1
- 101000914484 Homo sapiens T-lymphocyte activation antigen CD80 Proteins 0.000 claims 1
- 101000638251 Homo sapiens Tumor necrosis factor ligand superfamily member 9 Proteins 0.000 claims 1
- 101000851370 Homo sapiens Tumor necrosis factor receptor superfamily member 9 Proteins 0.000 claims 1
- 102100034980 ICOS ligand Human genes 0.000 claims 1
- 108091008036 Immune checkpoint proteins Proteins 0.000 claims 1
- 102000037982 Immune checkpoint proteins Human genes 0.000 claims 1
- 108090000174 Interleukin-10 Proteins 0.000 claims 1
- 102000013462 Interleukin-12 Human genes 0.000 claims 1
- 108010065805 Interleukin-12 Proteins 0.000 claims 1
- 108090000176 Interleukin-13 Proteins 0.000 claims 1
- 102000003810 Interleukin-18 Human genes 0.000 claims 1
- 108090000171 Interleukin-18 Proteins 0.000 claims 1
- 108010002386 Interleukin-3 Proteins 0.000 claims 1
- 102000000646 Interleukin-3 Human genes 0.000 claims 1
- 108010002616 Interleukin-5 Proteins 0.000 claims 1
- 108090001005 Interleukin-6 Proteins 0.000 claims 1
- 108090001007 Interleukin-8 Proteins 0.000 claims 1
- 102000004890 Interleukin-8 Human genes 0.000 claims 1
- 108010002335 Interleukin-9 Proteins 0.000 claims 1
- 108010061593 Member 14 Tumor Necrosis Factor Receptors Proteins 0.000 claims 1
- 241000187479 Mycobacterium tuberculosis Species 0.000 claims 1
- 102000004473 OX40 Ligand Human genes 0.000 claims 1
- 108010042215 OX40 Ligand Proteins 0.000 claims 1
- 102100024216 Programmed cell death 1 ligand 1 Human genes 0.000 claims 1
- 102100024213 Programmed cell death 1 ligand 2 Human genes 0.000 claims 1
- 101710188053 Protein D Proteins 0.000 claims 1
- 101710132893 Resolvase Proteins 0.000 claims 1
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims 1
- 102100027222 T-lymphocyte activation antigen CD80 Human genes 0.000 claims 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 1
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 1
- 102100032101 Tumor necrosis factor ligand superfamily member 9 Human genes 0.000 claims 1
- 102100028785 Tumor necrosis factor receptor superfamily member 14 Human genes 0.000 claims 1
- 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 claims 1
- 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims 1
- 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 claims 1
- 102100036856 Tumor necrosis factor receptor superfamily member 9 Human genes 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 229960005305 adenosine Drugs 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 239000002552 dosage form Substances 0.000 claims 1
- 238000003114 enzyme-linked immunosorbent spot assay Methods 0.000 claims 1
- 230000003053 immunization Effects 0.000 claims 1
- 238000002649 immunization Methods 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 238000012986 modification Methods 0.000 claims 1
- 230000004048 modification Effects 0.000 claims 1
- 230000003472 neutralizing effect Effects 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562101968P | 2015-01-09 | 2015-01-09 | |
| US62/101,968 | 2015-01-09 | ||
| PCT/US2016/012482 WO2016112188A1 (en) | 2015-01-09 | 2016-01-07 | Methods and compositions for ebola virus vaccination |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018502922A JP2018502922A (ja) | 2018-02-01 |
| JP2018502922A5 true JP2018502922A5 (https=) | 2019-02-14 |
Family
ID=56356425
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017555422A Pending JP2018502922A (ja) | 2015-01-09 | 2016-01-07 | エボラウイルスワクチン接種のための方法および組成物 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US10695417B2 (https=) |
| EP (1) | EP3256140B1 (https=) |
| JP (1) | JP2018502922A (https=) |
| KR (1) | KR20170102002A (https=) |
| CN (1) | CN107530383A (https=) |
| AU (1) | AU2016205208A1 (https=) |
| CA (1) | CA2973109A1 (https=) |
| ES (1) | ES2795833T3 (https=) |
| WO (1) | WO2016112188A1 (https=) |
Families Citing this family (16)
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| DK2170384T3 (en) | 2007-07-02 | 2016-07-25 | Etubics Corp | METHODS AND COMPOSITIONS FOR THE PRODUCTION OF AN adenovirus vector for use in higher vaccination |
| AU2016205208A1 (en) | 2015-01-09 | 2017-07-06 | Etubics Corporation | Methods and compositions for ebola virus vaccination |
| US10835596B2 (en) | 2016-07-15 | 2020-11-17 | Etubics Corporation | Compositions and methods for flavivirus vaccination |
| JP6903120B2 (ja) | 2016-07-15 | 2021-07-14 | エトゥビクス コーポレーション | アルファウイルスワクチン接種のための組成物及び方法 |
| US12209292B2 (en) | 2016-08-26 | 2025-01-28 | The Broad Institute, Inc. | Nucleic acid amplification assays for detection of pathogens |
| WO2021050778A1 (en) * | 2019-09-10 | 2021-03-18 | The Penn State Research Foundation | Lipopolysaccharide molecules for enhancing immune responses |
| US12285480B2 (en) | 2020-03-11 | 2025-04-29 | Nantcell, Inc. | Method of inducing immunity against SARS-CoV-2 using spike and nucleocapsid-ETSD immunogens delivered by RNA and replication-defective adenoviruses |
| US11857620B2 (en) | 2020-03-11 | 2024-01-02 | Immunitybio, Inc. | Method of inducing immunity against SARS-CoV-2 using spike (s) and nucleocapsid (N)-ETSD immunogens delivered by a replication-defective adenovirus |
| CN115244077B (zh) | 2020-03-11 | 2025-04-29 | 南特细胞公司 | 蛋白质治疗剂 |
| JP7692925B2 (ja) * | 2020-03-11 | 2025-06-16 | ナントセル，インコーポレイテッド | Ｃｏｖｉｄ－１９の治療及びその方法 |
| US20210284716A1 (en) * | 2020-03-11 | 2021-09-16 | Immunitybio, Inc. | ACE2-Fc Trap |
| CN117715929A (zh) | 2021-07-29 | 2024-03-15 | 南特细胞公司 | 用于预防和治疗病毒感染和癌症的经修饰的t细胞受体 |
| EP4335870A1 (en) | 2022-09-06 | 2024-03-13 | NantCell, Inc. | Peptide therapeutics against sars-cov-2 spike protein |
| WO2024228950A1 (en) * | 2023-05-04 | 2024-11-07 | Immunitybio, Inc. | Adenoviral vector transduced apheresis product |
| TW202548026A (zh) * | 2024-05-16 | 2025-12-16 | 瑞士商輝凌國際中心公司 | 用於純化重組腺病毒載體之方法 |
| WO2026006370A1 (en) | 2024-06-28 | 2026-01-02 | Immunitybio, Inc. | Anti-slamf7 antibodies and therapeutics |
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2016
- 2016-01-07 AU AU2016205208A patent/AU2016205208A1/en not_active Abandoned
- 2016-01-07 US US15/542,003 patent/US10695417B2/en active Active
- 2016-01-07 JP JP2017555422A patent/JP2018502922A/ja active Pending
- 2016-01-07 KR KR1020177022208A patent/KR20170102002A/ko not_active Ceased
- 2016-01-07 EP EP16735409.1A patent/EP3256140B1/en active Active
- 2016-01-07 CA CA2973109A patent/CA2973109A1/en not_active Abandoned
- 2016-01-07 WO PCT/US2016/012482 patent/WO2016112188A1/en not_active Ceased
- 2016-01-07 CN CN201680014847.2A patent/CN107530383A/zh active Pending
- 2016-01-07 ES ES16735409T patent/ES2795833T3/es active Active
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