JP2018501215A5 - - Google Patents
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- Publication number
- JP2018501215A5 JP2018501215A5 JP2017529357A JP2017529357A JP2018501215A5 JP 2018501215 A5 JP2018501215 A5 JP 2018501215A5 JP 2017529357 A JP2017529357 A JP 2017529357A JP 2017529357 A JP2017529357 A JP 2017529357A JP 2018501215 A5 JP2018501215 A5 JP 2018501215A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- alkyl
- salt according
- salt
- medicament
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 7
- 125000000217 alkyl group Chemical group 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 206010053219 non-alcoholic steatohepatitis Diseases 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462086844P | 2014-12-03 | 2014-12-03 | |
| US62/086,844 | 2014-12-03 | ||
| PCT/IB2015/058965 WO2016087975A1 (en) | 2014-12-03 | 2015-11-19 | Cd38 inhibitors and methods of treatment |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018501215A JP2018501215A (ja) | 2018-01-18 |
| JP2018501215A5 true JP2018501215A5 (cg-RX-API-DMAC10.html) | 2018-11-01 |
| JP6550132B2 JP6550132B2 (ja) | 2019-07-24 |
Family
ID=54708091
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017529357A Active JP6550132B2 (ja) | 2014-12-03 | 2015-11-19 | Ｃｄ３８阻害剤及び治療の方法 |
Country Status (11)
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018098348A1 (en) | 2016-11-23 | 2018-05-31 | Acetylon Pharmaceuticals, Inc. | Pharmaceutical combinations comprising a histone deacetylase inhibitor and a cd38 inhibitor and methods of use thereof |
| JOP20210164A1 (ar) | 2019-01-11 | 2023-01-30 | Omeros Corp | طرق وتركيبات علاج السرطان |
| US11535621B2 (en) * | 2019-07-31 | 2022-12-27 | Ribon Therapeutics, Inc. | Heterobicyclic amides as inhibitors of CD38 |
| TW202128677A (zh) * | 2019-10-30 | 2021-08-01 | 美商米突倍基公司 | Cd38抑制劑 |
| JP7792915B2 (ja) * | 2020-04-07 | 2025-12-26 | アステラス エンジニアード スモール モレキュールズ ユーエス インコーポレイテッド | Ｃｄ３８阻害薬 |
| AU2021356641A1 (en) * | 2020-10-09 | 2023-06-15 | Buck Institute For Research On Aging | Heteroaryl amide inhibitors of cd38 |
| HRP20251111T1 (hr) | 2021-01-29 | 2025-11-21 | Boehringer Ingelheim International Gmbh | Azakinolini kao inhibitori cd38 |
| JP2024517750A (ja) * | 2021-04-30 | 2024-04-23 | ナンキン イムノファージ バイオテック カンパニー リミテッド | 化合物及びそれらのｃｄ３８阻害剤としての使用 |
| IL310096A (en) * | 2021-07-12 | 2024-03-01 | Cytokinetics Inc | CD38 modulators and methods of using them |
| AU2024285368A1 (en) * | 2023-06-07 | 2025-12-18 | Flagship Pioneering Innovations Vi, Llc | Condensed azines as inhibitors of cyclic adp ribose hydrolase |
| CN119775288B (zh) * | 2024-12-31 | 2025-10-10 | 浙江工业大学 | 一种cd38抑制化合物及应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2433840C (en) * | 2001-01-04 | 2010-05-04 | Albert Einstein College Of Medicine Of Yeshiva University | Inhibitors of adp-ribosyl transferases, cyclases, and hydrolases, and uses thereof |
| US7022680B2 (en) * | 2002-05-30 | 2006-04-04 | Albert Einstein College Of Medicine Of Yeshiva University | Inhibitors of ADP-ribosyl transferases, cyclases, and hydrolases |
| US8283368B2 (en) * | 2008-08-29 | 2012-10-09 | The Regents Of The University Of Michigan | Selective ligands for the dopamine 3 (D3) receptor and methods of using the same |
| EP2801573A1 (en) * | 2013-05-09 | 2014-11-12 | Sanofi | Hydantoine derivatives as CD38 inhibitors |
-
2015
- 2015-11-19 JP JP2017529357A patent/JP6550132B2/ja active Active
- 2015-11-19 WO PCT/IB2015/058965 patent/WO2016087975A1/en not_active Ceased
- 2015-11-19 ES ES15801951T patent/ES2717260T3/es active Active
- 2015-11-19 CN CN201580073761.2A patent/CN107428733A/zh active Pending
- 2015-11-19 US US15/529,120 patent/US9840496B2/en active Active
- 2015-11-19 BR BR112017011642A patent/BR112017011642A2/pt not_active Application Discontinuation
- 2015-11-19 RU RU2017121002A patent/RU2017121002A/ru not_active Application Discontinuation
- 2015-11-19 CA CA2969178A patent/CA2969178A1/en not_active Abandoned
- 2015-11-19 AU AU2015356721A patent/AU2015356721B2/en not_active Ceased
- 2015-11-19 EP EP15801951.3A patent/EP3227275B1/en active Active
- 2015-11-19 KR KR1020177018180A patent/KR20170090478A/ko not_active Withdrawn
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