JP2018500373A - 原発性副甲状腺機能亢進症を処置するための２−メチレン−１９−ノル−（２０Ｓ）−１α，２５−ジヒドロキシビタミンＤ３の使用 - Google Patents

原発性副甲状腺機能亢進症を処置するための２−メチレン−１９−ノル−（２０Ｓ）−１α，２５−ジヒドロキシビタミンＤ３の使用 Download PDF

Info

Publication number
JP2018500373A
JP2018500373A JP2017534936A JP2017534936A JP2018500373A JP 2018500373 A JP2018500373 A JP 2018500373A JP 2017534936 A JP2017534936 A JP 2017534936A JP 2017534936 A JP2017534936 A JP 2017534936A JP 2018500373 A JP2018500373 A JP 2018500373A
Authority
JP
Japan
Prior art keywords
primary hyperparathyroidism
subject
symptoms
pth
hyperparathyroidism
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2017534936A
Other languages
English (en)
Japanese (ja)
Other versions
JP2018500373A5 (https=
Inventor
ヘクター エフ． デルーカ
ヘクター エフ． デルーカ
ローリー エイ． プラム
ローリー エイ． プラム
マーガレット クラーゲット−デーム
マーガレット クラーゲット−デーム
Original Assignee
ウイスコンシン アラムニ リサーチ ファンデーション
ウイスコンシン アラムニ リサーチ ファンデーション
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ウイスコンシン アラムニ リサーチ ファンデーション, ウイスコンシン アラムニ リサーチ ファンデーション filed Critical ウイスコンシン アラムニ リサーチ ファンデーション
Publication of JP2018500373A publication Critical patent/JP2018500373A/ja
Publication of JP2018500373A5 publication Critical patent/JP2018500373A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A61P5/04—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin for decreasing, blocking or antagonising the activity of the hypothalamic hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
    • A61P5/20—Drugs for disorders of the endocrine system of the parathyroid hormones for decreasing, blocking or antagonising the activity of PTH

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2017534936A 2014-12-30 2015-12-11 原発性副甲状腺機能亢進症を処置するための２−メチレン−１９−ノル−（２０Ｓ）−１α，２５−ジヒドロキシビタミンＤ３の使用 Pending JP2018500373A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462098119P 2014-12-30 2014-12-30
US62/098,119 2014-12-30
US14/710,744 US10369161B2 (en) 2014-12-30 2015-05-13 Use of 2-methylene-19-NOR-(20S)-1-alpha,25-dihydroxyvitamin D3 to treat primary hyperparathyroidism
US14/710,744 2015-05-13
PCT/US2015/065174 WO2016109155A1 (en) 2014-12-30 2015-12-11 USE OF 2-METHYLENE-19-NOR-(20S)-1α,25-DIHYDROXYVITAMIN D3 TO TREAT PRIMARY HYPERPARATHYROIDISM

Publications (2)

Publication Number Publication Date
JP2018500373A true JP2018500373A (ja) 2018-01-11
JP2018500373A5 JP2018500373A5 (https=) 2018-09-13

Family

ID=56162989

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2017534936A Pending JP2018500373A (ja) 2014-12-30 2015-12-11 原発性副甲状腺機能亢進症を処置するための２−メチレン−１９−ノル−（２０Ｓ）−１α，２５−ジヒドロキシビタミンＤ３の使用

Country Status (6)

Country Link
US (1) US10369161B2 (https=)
EP (1) EP3240548A1 (https=)
JP (1) JP2018500373A (https=)
AU (1) AU2015374467A1 (https=)
CA (1) CA2969335A1 (https=)
WO (1) WO2016109155A1 (https=)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002516299A (ja) * 1998-05-29 2002-06-04 ボーン ケア インターナショナル インコーポレイテッド ２４−ヒドロキシビタミンｄ、類似体及びその使用
WO2014003849A1 (en) * 2012-06-29 2014-01-03 Wisconsin Alumni Research Foundation USE OF 2-METHYLENE-19-NOR-(20S)-1α,25-DIHYDROXYVITAMIN D3 TO TREAT SECONDARY HYPERPARATHYROIDISM

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040043971A1 (en) 1995-04-03 2004-03-04 Bone Care International, Inc. Method of treating and preventing hyperparathyroidism with active vitamin D analogs
US5843928A (en) 1997-03-17 1998-12-01 Wisconsin Alumni Research Foundation 2-alkylidene-19-nor-vitamin D compounds
US6306844B1 (en) 1997-03-17 2001-10-23 Wisconsin Alumni Research Foundation Use of 2α-methyl-19-nor-20(S)-1α, 25-dihydroxyvitamin D3 to increase bone strength
US6136799A (en) 1998-04-08 2000-10-24 Abbott Laboratories Cosolvent formulations
US6673782B2 (en) 1999-04-29 2004-01-06 Wisconsin Alumni Research Foundation Treatment of systemic lupus erythematosis
JP2003528833A (ja) 2000-03-27 2003-09-30 ウイスコンシン アラムナイ リサーチ フオンデーシヨン 腎移植体安定化用のビタミンｄ化合物
MXPA03000406A (es) 2000-07-14 2003-06-06 Wisconsin Alumni Res Found Uso de 2-metilen-19-nor-20(s)-1 alfa,25-dihidroxivitamina d3 para incrementar la resistencia de los huesos.
US20050124591A1 (en) 2003-07-29 2005-06-09 Jin Tian Use of vitamin Ds to treat kidney disease
US20060171983A1 (en) 2003-07-30 2006-08-03 Jin Tian Use of Vitamin D receptor activators or Vitamin D analogs to treat cardiovascular disease
US7704980B2 (en) 2003-10-08 2010-04-27 Wisconsin Alumni Research Foundation Treatment of inflammatory bowel disease with 2-methylene-19-nor-vitamin D compounds
US7214671B2 (en) 2004-02-19 2007-05-08 Wisconsin Alumni Research Foundation Use of 2-methylene-19-nor-20(S)-1α,25-dihydroxyvitamin D3 for the prophylaxis of bone diseases
WO2006086613A2 (en) 2005-02-11 2006-08-17 Wisconsin Alumni Research Foundation 2-METHYLENE-19-NOR- (20S-24S) - 1α, 25-D IHYDROXYVITAMIN-D2
AU2010281391B2 (en) 2009-08-03 2015-05-07 Wisconsin Alumni Research Foundation Method of preventing renal disease and treating symptoms thereof
US8604009B2 (en) 2010-03-23 2013-12-10 Wisconsin Alumni Research Foundation (20S)-2-methylene-19-nor-22-dimethyl-1α,25-dihydroxyvitamin D3 and (20R)-2-methylene-19-nor-22-dimethyl-1α,25-hydroxyvitamin D3

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002516299A (ja) * 1998-05-29 2002-06-04 ボーン ケア インターナショナル インコーポレイテッド ２４−ヒドロキシビタミンｄ、類似体及びその使用
WO2014003849A1 (en) * 2012-06-29 2014-01-03 Wisconsin Alumni Research Foundation USE OF 2-METHYLENE-19-NOR-(20S)-1α,25-DIHYDROXYVITAMIN D3 TO TREAT SECONDARY HYPERPARATHYROIDISM

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
"I.高カルシウム血症 2.原発性副甲状腺機能亢進症", 日本内科学会雑誌, vol. 96 (4), JPN6019014096, 2007, pages 662 - 668, ISSN: 0004211705 *
"Novel, Selective Vitamin D Analog Suppresses Parathyroid Hormone in Uremic Animals and Postmenopausa", AMERICAN JOURNAL OF NEPHROLOGY, vol. 39 (6), JPN6019014102, 17 May 2014 (2014-05-17), pages 476 - 483, ISSN: 0004211708 *
"The development of a bone- and parathyroid-specific analog of vitamin D: 2-methylene-19-nor-(20S)-1", BONEKEY REPORTS, vol. 3, JPN6019014100, 5 March 2014 (2014-03-05), pages 1 - 514, ISSN: 0004211707 *
"Vitamin D repletion in patients with primary hyperparathyroidism and coexistent vitamin D insufficie", JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, vol. 90 (4), JPN6019014098, 2005, pages 2122 - 2126, ISSN: 0004211706 *

Also Published As

Publication number Publication date
US20160184327A1 (en) 2016-06-30
CA2969335A1 (en) 2016-07-07
US10369161B2 (en) 2019-08-06
AU2015374467A1 (en) 2017-06-15
WO2016109155A1 (en) 2016-07-07
EP3240548A1 (en) 2017-11-08

Similar Documents

Publication Publication Date Title
JP6375353B2 (ja) ２５−ヒドロキシビタミンｄ３を含む経口剤形、及び、その経口剤形を週１回ヒトに投与することを含む方法
US10046000B2 (en) Use of 2-methylene-19-nor-(20S)-1α,25-Dihydroxyvitamin D3 to treat and prevent secondary hyperparathyroidism in a subject having renal failure
CA2777938C (en) Method of preventing type 1 diabetes
US9814736B2 (en) Use of 2-methylene-19-nor-(20S)-1α,25-dihydroxyvitamin D3 and calcimimetics to treat secondary hyperparathyroidism
JP7507772B2 (ja) 筋痙攣の予防及び治療のためのケイ素及びマグネシウムの組合せ物
JP2018500373A (ja) 原発性副甲状腺機能亢進症を処置するための２−メチレン−１９−ノル−（２０Ｓ）−１α，２５−ジヒドロキシビタミンＤ３の使用
US10105375B2 (en) Combination of low dose 2-methylene-19-nor-(20S)1α, 25-dihydroxyvitamin D3 and calcimimetics to treat secondary hyperparathyroidism

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20171006

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20180802

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20180802

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20190411

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20190418

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20190717

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20200212