JP2018500317A5 - - Google Patents

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Publication number
JP2018500317A5
JP2018500317A5 JP2017531893A JP2017531893A JP2018500317A5 JP 2018500317 A5 JP2018500317 A5 JP 2018500317A5 JP 2017531893 A JP2017531893 A JP 2017531893A JP 2017531893 A JP2017531893 A JP 2017531893A JP 2018500317 A5 JP2018500317 A5 JP 2018500317A5
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JP
Japan
Prior art keywords
trolox
item
salt
resolving agent
mixture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2017531893A
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English (en)
Japanese (ja)
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JP2018500317A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2015/066208 external-priority patent/WO2016100576A1/en
Publication of JP2018500317A publication Critical patent/JP2018500317A/ja
Publication of JP2018500317A5 publication Critical patent/JP2018500317A5/ja
Withdrawn legal-status Critical Current

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JP2017531893A 2014-12-16 2015-12-16 トロロックスのキラル分割のための方法 Withdrawn JP2018500317A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462092743P 2014-12-16 2014-12-16
US62/092,743 2014-12-16
US201562133276P 2015-03-13 2015-03-13
US62/133,276 2015-03-13
PCT/US2015/066208 WO2016100576A1 (en) 2014-12-16 2015-12-16 Methods for chiral resolution of trolox

Publications (2)

Publication Number Publication Date
JP2018500317A JP2018500317A (ja) 2018-01-11
JP2018500317A5 true JP2018500317A5 (https=) 2019-01-31

Family

ID=56684375

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2017531893A Withdrawn JP2018500317A (ja) 2014-12-16 2015-12-16 トロロックスのキラル分割のための方法

Country Status (4)

Country Link
US (1) US20180002247A1 (https=)
EP (1) EP3233819A1 (https=)
JP (1) JP2018500317A (https=)
WO (1) WO2016100576A1 (https=)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2471530B1 (en) 2005-06-01 2017-01-11 Edison Pharmaceuticals, Inc. Redox-active therapeutics for treatment of mitochondrial diseases and other conditions and modulation of energy biomarkers
WO2009061744A2 (en) 2007-11-06 2009-05-14 Edison Pharmaceuticals, Inc. 4- (p-quinonyl)-2-hydroxybutanamide derivatives for treatment of mitochondrial diseases
CA2741767C (en) 2008-10-28 2017-09-12 Ptc Therapeutics, Inc. Process for the production of alpha-tocotrienol and derivatives
JP2014520894A (ja) 2011-07-19 2014-08-25 エジソン ファーマシューティカルズ， インコーポレイテッド 非アルファトコトリエノールの存在下でのアルファトコトリエノールの選択的酸化のための方法
AU2015364640B2 (en) 2014-12-16 2020-08-13 Ptc Therapeutics, Inc. Polymorphic and amorphous forms of (R)-2-hydroxy-2-methyl-4-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dienyl)butanamide
EP3390377B1 (en) 2015-12-16 2026-03-25 PTC Therapeutics, Inc. Improved methods for enriching alpha-tocotrienol from mixed tocol compositions
WO2017106803A1 (en) 2015-12-17 2017-06-22 Bioelectron Technology Corporation Flouroalkyl, flouroalkoxy, phenoxy, heteroaryloxy, alkoxy, and amine 1,4-benzoquinone derivatives for treatment of oxidative stress disorders
JP2018083799A (ja) 2016-11-15 2018-05-31 バイオエレクトロン テクノロジー コーポレイション ２−置換アミノ−ナフト［１，２−ｄ］イミダゾール−５−オン化合物またはその製薬学上許容される塩
US11761953B2 (en) 2019-11-14 2023-09-19 Senseonics, Incorporated Mediation of in vivo analyte signal degradation
KR20220143897A (ko) * 2020-02-21 2022-10-25 스미토모 파마 가부시키가이샤 광학 분할된 트롤록스 중간체 및 그 제조 방법
JP7223738B2 (ja) 2020-11-12 2023-02-16 株式会社アルバック スパッタリング装置
EP4596530A1 (en) * 2022-09-30 2025-08-06 PTC Therapeutics, Inc. Oxidative cleavage method of trolox amide
CN118126011A (zh) * 2024-01-22 2024-06-04 辽宁大学 一种手性拆分Trolox及Trolox酯类化合物对映异构体的方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3947473A (en) 1972-12-22 1976-03-30 Hoffman-La Roche Inc. Antioxidant chroman compounds
US4003919A (en) 1973-11-19 1977-01-18 Hoffmann-La Roche Inc. Antioxidant chroman compounds
US4026907A (en) 1973-11-19 1977-05-31 Hoffmann-La Roche Inc. Antioxidant chroman compounds
US4018799A (en) * 1973-11-19 1977-04-19 Hoffmann-La Roche Inc. Antioxidant chroman compounds
US5348973A (en) * 1990-10-09 1994-09-20 Rhone-Poulenc Chimie Resolution of hydroxychroman-2-carboxylic acid esters by enantiomeric hydrolysis
JP3913329B2 (ja) * 1997-09-11 2007-05-09 株式会社クラレ （±）−クロマンカルボン酸の光学分割法
WO2002012221A1 (en) * 2000-08-03 2002-02-14 Kuraray Co., Ltd. Method for optical resolution of (±)-6-hydroxy-2,5,7,8-tetramethylcoumarone-2-carboxylic acid
EP2471530B1 (en) 2005-06-01 2017-01-11 Edison Pharmaceuticals, Inc. Redox-active therapeutics for treatment of mitochondrial diseases and other conditions and modulation of energy biomarkers
EP2088144B1 (en) * 2006-10-26 2011-12-28 Mitsubishi Gas Chemical Company, Inc. Method of producing s-(-)-6-hydroxy-2,5,7,8-tetramethylchromane-2-carboxylic acid
WO2009061744A2 (en) * 2007-11-06 2009-05-14 Edison Pharmaceuticals, Inc. 4- (p-quinonyl)-2-hydroxybutanamide derivatives for treatment of mitochondrial diseases
JP5266875B2 (ja) * 2008-05-23 2013-08-21 三菱瓦斯化学株式会社 有機カルボン酸エステルからの光学活性有機カルボン酸の製造方法
WO2010050499A1 (ja) 2008-10-29 2010-05-06 三菱瓦斯化学株式会社 光学活性有機カルボン酸の製造方法

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