JP2018500317A5 - - Google Patents

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Publication number
JP2018500317A5
JP2018500317A5 JP2017531893A JP2017531893A JP2018500317A5 JP 2018500317 A5 JP2018500317 A5 JP 2018500317A5 JP 2017531893 A JP2017531893 A JP 2017531893A JP 2017531893 A JP2017531893 A JP 2017531893A JP 2018500317 A5 JP2018500317 A5 JP 2018500317A5
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JP
Japan
Prior art keywords
trolox
item
salt
resolving agent
mixture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2017531893A
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English (en)
Japanese (ja)
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JP2018500317A (ja
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Publication date
Application filed filed Critical
Priority claimed from PCT/US2015/066208 external-priority patent/WO2016100576A1/en
Publication of JP2018500317A publication Critical patent/JP2018500317A/ja
Publication of JP2018500317A5 publication Critical patent/JP2018500317A5/ja
Withdrawn legal-status Critical Current

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JP2017531893A 2014-12-16 2015-12-16 トロロックスのキラル分割のための方法 Withdrawn JP2018500317A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462092743P 2014-12-16 2014-12-16
US62/092,743 2014-12-16
US201562133276P 2015-03-13 2015-03-13
US62/133,276 2015-03-13
PCT/US2015/066208 WO2016100576A1 (en) 2014-12-16 2015-12-16 Methods for chiral resolution of trolox

Publications (2)

Publication Number Publication Date
JP2018500317A JP2018500317A (ja) 2018-01-11
JP2018500317A5 true JP2018500317A5 (https=) 2019-01-31

Family

ID=56684375

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2017531893A Withdrawn JP2018500317A (ja) 2014-12-16 2015-12-16 トロロックスのキラル分割のための方法

Country Status (4)

Country Link
US (1) US20180002247A1 (https=)
EP (1) EP3233819A1 (https=)
JP (1) JP2018500317A (https=)
WO (1) WO2016100576A1 (https=)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2619303T3 (es) 2005-06-01 2017-06-26 Edison Pharmaceuticals, Inc. Productos terapéuticos redox activos para el tratamiento de enfermedades mitocondriales y otras afecciones y modulación de biomarcadores energéticos
EA038941B1 (ru) 2007-11-06 2021-11-12 ПиТиСи ТЕРАПЬЮТИКС, ИНК. ПРОИЗВОДНЫЕ 4-(п-ХИНОНИЛ)-2-ГИДРОКСИБУТАНАМИДА ДЛЯ ЛЕЧЕНИЯ МИТОХОНДРИАЛЬНЫХ ЗАБОЛЕВАНИЙ
ES2553557T3 (es) 2008-10-28 2015-12-10 Edison Pharmaceuticals, Inc. Proceso para la producción de alfa-tocotrienol y derivados
EP2734512B1 (en) 2011-07-19 2019-11-20 Bioelectron Technology Corporation Methods for selective oxidation of alpha tocotrienol in the presence of non-alpha tocotrienols
DK3233786T3 (da) 2014-12-16 2022-05-09 Ptc Therapeutics Inc Polymorfe og amorfe former af (r)-2-hydroxy-2-methyl-4-(2,4,5-trimethyl-3,6- dioxocyclohexa-1,4-dienyl)butanamid
WO2017106786A1 (en) 2015-12-16 2017-06-22 Bioelectron Technology Corporation Improved methods for enriching alpha-tocotrienol from mixed tocol compositions
US10703701B2 (en) 2015-12-17 2020-07-07 Ptc Therapeutics, Inc. Fluoroalkyl, fluoroalkoxy, phenoxy, heteroaryloxy, alkoxy, and amine 1,4-benzoquinone derivatives for treatment of oxidative stress disorders
JP2018083799A (ja) 2016-11-15 2018-05-31 バイオエレクトロン テクノロジー コーポレイション ２−置換アミノ−ナフト［１，２−ｄ］イミダゾール−５−オン化合物またはその製薬学上許容される塩
WO2021097249A1 (en) * 2019-11-14 2021-05-20 Senseonics, Incorporated Mediation of in vivo analyte signal degradation
EP4108658A4 (en) * 2020-02-21 2024-05-22 Sumitomo Pharma Co., Ltd. OPTICALLY RESOLVED TROLOX INTERMEDIATE AND PRODUCTION METHOD THEREFOR
JP7223738B2 (ja) 2020-11-12 2023-02-16 株式会社アルバック スパッタリング装置
AU2023352262A1 (en) * 2022-09-30 2025-04-24 Ptc Therapeutics, Inc. Oxidative cleavage method of trolox amide
CN118126011A (zh) * 2024-01-22 2024-06-04 辽宁大学 一种手性拆分Trolox及Trolox酯类化合物对映异构体的方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3947473A (en) 1972-12-22 1976-03-30 Hoffman-La Roche Inc. Antioxidant chroman compounds
US4018799A (en) * 1973-11-19 1977-04-19 Hoffmann-La Roche Inc. Antioxidant chroman compounds
US4026907A (en) 1973-11-19 1977-05-31 Hoffmann-La Roche Inc. Antioxidant chroman compounds
US4003919A (en) 1973-11-19 1977-01-18 Hoffmann-La Roche Inc. Antioxidant chroman compounds
US5348973A (en) * 1990-10-09 1994-09-20 Rhone-Poulenc Chimie Resolution of hydroxychroman-2-carboxylic acid esters by enantiomeric hydrolysis
JP3913329B2 (ja) * 1997-09-11 2007-05-09 株式会社クラレ （±）−クロマンカルボン酸の光学分割法
WO2002012221A1 (en) * 2000-08-03 2002-02-14 Kuraray Co., Ltd. Method for optical resolution of (±)-6-hydroxy-2,5,7,8-tetramethylcoumarone-2-carboxylic acid
ES2619303T3 (es) 2005-06-01 2017-06-26 Edison Pharmaceuticals, Inc. Productos terapéuticos redox activos para el tratamiento de enfermedades mitocondriales y otras afecciones y modulación de biomarcadores energéticos
US8080676B2 (en) * 2006-10-26 2011-12-20 Mitsubishi Gas Chemical Company, Inc. Method of producing S-(−)-6-hydroxy-2,5,7,8-tetramethylchromane-2-carboxylic acid and product obtained by the method
EA038941B1 (ru) * 2007-11-06 2021-11-12 ПиТиСи ТЕРАПЬЮТИКС, ИНК. ПРОИЗВОДНЫЕ 4-(п-ХИНОНИЛ)-2-ГИДРОКСИБУТАНАМИДА ДЛЯ ЛЕЧЕНИЯ МИТОХОНДРИАЛЬНЫХ ЗАБОЛЕВАНИЙ
JP5266875B2 (ja) * 2008-05-23 2013-08-21 三菱瓦斯化学株式会社 有機カルボン酸エステルからの光学活性有機カルボン酸の製造方法
JP5598330B2 (ja) 2008-10-29 2014-10-01 三菱瓦斯化学株式会社 光学活性有機カルボン酸の製造方法

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