JP2018145121A - Powder beverage composition and use therefor - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a powder beverage composition containing at least one of chondroitin and hyaluronic acid, in which a raw material that can be labeled as food is used, and at least one of flowability and solubility is improved.SOLUTION: A powder beverage composition contains (A) component: at least one of chondroitin and hyaluronic acid, and (B) component: 3-hydroxy isovaleric acid and/or a salt thereof.SELECTED DRAWING: None

Description

  The present invention relates to a powdered beverage composition and uses thereof.

  Chondroitin, hyaluronic acid, glucosamine, collagen, and the like are used in many functional foods as joint care materials for smooth bending and stretching of knee joints.

  Chondroitin, hyaluronic acid, and collagen are components constituting cartilage, have high water absorption, and have a function of improving the cushioning property of the knee joint. Glucosamine is effective in maintaining an anti-inflammatory action and the amount of proteoglycan constituting the joint, and reduces pain in the knee joint.

  By the way, in order to secure a function that can be obtained with a functional food containing the above-mentioned raw materials, a large amount of ingestion is required. For example, in the case of a tablet, it may be required to ingest 10 or more tablets at a time. Therefore, in consideration of consumer use, it is preferable to market in powder form and dissolve in water at the time of use and take it as a beverage.

Since chondroitin, hyaluronic acid, and collagen have high water absorption, there is a problem that fluidity decreases when stored for a long period of time. In addition, glucosamine is a substance that is easily crystallized, and has a problem that, when stored for a long period of time, it solidifies (blocks) and fluidity decreases.
Thus, when a raw material whose fluidity is likely to be lowered is used in a powdered soft drink or the like, there is a concern that production problems such as mixing failure and usability problems such as a decrease in solubility may occur.

  As a technique for improving the fluidity of glucosamine, granulated powder or granules containing glucosamine or a salt thereof and at least one lubricant selected from the group consisting of calcium phosphate, fine silicon dioxide, calcium stearate, and magnesium stearate Has been proposed (see, for example, Patent Document 1).

  For the purpose of obtaining an easily soluble high protein-containing powder, an easily soluble high protein-containing powder comprising a step of granulating by adding an aqueous solution containing a diglycerin fatty acid ester to a high protein-containing powder composition such as collagen powder Has been proposed (see, for example, Patent Document 2).

JP 2012-62279 A Japanese Patent Laid-Open No. 2006-116494

The lubricant (fine silicon dioxide, calcium phosphate, calcium silicate, etc.) described in Patent Document 1 can be used for foods and is a material that improves fluidity. However, these materials need to be labeled as food additives (substance names or anti-caking agents) and tend not to be preferred by general consumers. Moreover, the diglycerin fatty acid ester described in Patent Document 2 also needs to be labeled as a food additive and tends to be unfavorable to general consumers. In addition, many food additives have a limited amount of use, and the improvement effect may be poor depending on the type and composition of the additive.
Therefore, when a functional food containing chondroitin or the like as a raw material is marketed as a powdered beverage, in view of the consumer's tendency and improvement effect, a raw material that can be displayed as a food is desired as an additive that improves fluidity. Yes.

  An object of the present invention is to provide a powdered beverage composition containing at least one of chondroitin and hyaluronic acid, using a raw material that can be displayed as a food, and having improved at least one of fluidity and solubility Is to provide.

  As a result of intensive studies on the above problems, the present inventors have found that a powder beverage composition containing at least one of (A) component: chondroitin and hyaluronic acid has (B) component: 3-hydroxyisovaleric acid and / or It has been found that the above problems can be solved by further containing the salts (hereinafter collectively referred to as “HMB”), and the present invention has been completed. Further, it has been found that the effect of improving fluidity and solubility is further enhanced by further containing (C) component: at least one selected from the group consisting of glucosamine and / or a salt thereof and collagen. .

That is, the present inventors provide the following [1] to [10].
[1] A powdered beverage composition containing (A) component: at least one of chondroitin and hyaluronic acid, and (B) component: HMB.
[2] The powder beverage composition according to [1], wherein the chondroitin in the component (A) is chondroitin contained in a chondroitin-containing shark cartilage extract.
[3] The powder beverage composition according to the above [1] or [2], further comprising (C) component: at least one selected from the group consisting of glucosamine and / or a salt thereof and collagen.
[4] Fluidity improver containing (A) component: at least one of chondroitin and hyaluronic acid, and (B) component: HMB.
[5] A solubility improver containing (A) component: at least one of chondroitin and hyaluronic acid, and (B) component: HMB.
[6] The agent according to [4] or [5] above, wherein the chondroitin in the component (A) is chondroitin contained in a chondroitin-containing shark cartilage extract.
[7] Component (C): The agent according to any one of [4] to [6], further containing at least one selected from the group consisting of glucosamine and / or a salt thereof, and collagen.
[8] Component (A): a method for improving at least one of fluidity and solubility of a composition containing at least one of chondroitin and hyaluronic acid, and (B) component: a method of adding HMB.
[9] The method according to [8] above, wherein the chondroitin in the component (A) is chondroitin contained in a chondroitin-containing shark cartilage extract.
[10] The method according to [8] or [9] above, wherein the composition further comprises at least one selected from the group consisting of component (C): glucosamine and / or a salt thereof, and collagen.

  ADVANTAGE OF THE INVENTION According to this invention, the powder drink composition which utilized the raw material which can be displayed as a foodstuff, and improved at least any one of fluidity | liquidity and solubility can be provided.

  Hereinafter, the present invention will be described in detail with reference to preferred embodiments thereof.

[1. Powdered beverage composition]
The powder beverage composition of the present invention contains (A) component: at least one of chondroitin and hyaluronic acid, and (B) component: HMB.
The powdered beverage composition of this invention can be utilized as a functional food which improves the cushioning property of a knee joint by containing (A) component. In addition, (A) component is 1 type of glycosaminoglycan (mucopolysaccharide), and is a component inferior to fluidity | liquidity and solubility normally.
Moreover, even if it is a powdered drink composition containing the (A) component inferior to fluidity | liquidity and solubility by containing the (B) component, the powdered beverage composition of this invention is fluid and soluble. At least one of them can be improved.

HMB is a metabolite of leucine and is known as a muscle care material that is effective in increasing muscle mass and strength. Also, HMB is classified as a food, not a food additive. In recent years, the use of HMB in beverages has been frequently studied, but it is known that HMB is produced as a precipitate by the components used in combination. Therefore, HMB is considered inappropriate as an additive for improving the fluidity and solubility of the powdered beverage composition.
However, while HMB is considered inappropriate as an additive for improving fluidity and solubility, the present inventors manufactured a powder beverage composition containing component (A) and HMB. We found that sex improved.

The powder beverage composition of the present invention preferably further contains at least one selected from the group consisting of component (C): glucosamine and / or a salt thereof, and collagen.
When collagen is contained as the component (C), the fluidity and solubility of the powder beverage composition can be further improved. Moreover, the cushioning property of the knee joint as a functional food can be further improved.
When glucosamine is contained as the component (C), the fluidity and solubility of the powder beverage composition can be further improved. It can also be used as a functional food to reduce knee joint pain.

  The daily intake of the powdered beverage composition of the present invention is determined by the content of the component (A), and is set according to the age, weight, and symptoms of the intake target person. In addition, it may be taken once per day or divided into several times, and may be taken at any timing before, between, after, or during a meal.

[1-1. (A) component]
The component (A) is at least one of chondroitin and hyaluronic acid. Component (A) is a component that constitutes cartilage, is known to have a high water absorbency and to increase the cushioning properties of the knee joint, and is used as a functional food.

(Chondroitin)
Chondroitin is widely distributed in the human body as chondroitin sulfate, and since it is abundantly contained in the cartilage and skin of joints, it is a healthy food aimed at improving osteoarthritis and skin beauty. It's being used. Chondroitin used as component (A) of the powder beverage composition of the present invention is chondroitin sulfate, which is a sulfate ester thereof, in addition to chondroitin, which is a kind of mucopolysaccharide consisting of hexosamine and uronic acid, and physiologically acceptable salts thereof. (For example, sodium salt). A large amount of chondroitin is contained in the cornea, the lens, the ciliary muscle, the vitreous body, the cartilage, the bone, the tendon, the blood vessel wall, the skin and the like in a state of being bound to the protein, and a chondroitin-protein complex can also be used.
Chondroitin can be obtained from animal cartilage or the like, but chemically synthesized or a mixture thereof may be used. In addition to purified chondroitin, for example, cartilage powder or cartilage extract can be used as long as it contains chondroitin as a component.

  Examples of cartilage containing a high concentration of chondroitin sulfate include shark cartilage, whale cartilage, squid cartilage, salmon cartilage, chicken cartilage, pig cartilage, and bovine cartilage. Of these, shark cartilage is preferred. Shark cartilage is not limited with respect to the type of shark from which it is derived, and examples include abalone shark and blue shark. Furthermore, there is no restriction | limiting also about the origin part of a cartilage, For example, a head, a fin, etc. are mentioned.

Examples of the raw material derived from shark cartilage include shark cartilage powder and shark cartilage extract. The chondroitin-containing shark cartilage extract is widely used as a health food material containing chondroitin at a high concentration, and is one of the preferred forms of the component (A) of the powdered beverage composition of the present invention.
Chondroitin-containing shark cartilage extract is, for example, shredded shark cartilage, extracted by treatment with a proteolytic enzyme in a solvent such as water, purified by a method such as adsorption or filtration, and an excipient such as dextrin In addition, a powder form obtained by spray drying or the like can be used. The main component of the chondroitin-containing shark cartilage extract is sodium chondroitin sulfate which is a polysaccharide having a molecular weight of about 100,000 to several hundred thousand.

  As chondroitin, a commercially available product may be used. For example, under the trade names, chondroitin sulfate 20, chondroitin sulfate 40 (above, manufactured by Toyo Fermentation Co., Ltd.), SCP, SCP (NB), SCP Super Fine 70, SNC-20N, SNC-40N, salmon PG-20, salmon PG, Squid-CS20, SC20 (above, Maruha Nichiro Foods, Inc.), pork chondroitin 20FF, pork chondroitin 40FF, pork chondroitin 20HJ, chondroitin sulfate sodium (above, Nippon Biocon), shark-derived chondroitin sulfate CP-55 (Biocorp Japan) Manufactured), SCS-20, SCS-40 (above, Yaegaki Fermentation Giken Co., Ltd.), Mariner Tridge S, Mariner Tridge 40S (above, YSK Yaizu Suisan Chemical Co., Ltd.), MC Chondroitin Sulfate Protein Complex, SCS Chondroitin Sulfuric acid N (Nippon Barrier Free), chondroitin sulfate A sodium salt, chondroitin sulfate B sodium salt, chondroitin sulfate C sodium, chondroitin sulfate sodium salt (above, Wako Pure Chemical Industries, Ltd.), chondroitin sulfate sodium (manufactured by Junsei Kagaku Co., Ltd. CAS No. 9082-07-9), external standard chondroitin sulfate sodium (GK) (manufactured by Seikagaku Corporation).

When chondroitin is sodium chondroitin sulfate, the amount of chondroitin can be determined with reference to a daily intake of 0.2 to 600 mg, preferably 10 to 200 mg per adult. The amount of chondroitin is, for example, in the case of sodium chondroitin sulfate, usually 0.004 to 20% by mass, preferably 0.1 to 15% by mass, based on the total mass of the powder beverage composition. Preferably it is 0.8-8 mass%.
When using chondroitin contained in chondroitin-containing shark cartilage extract as chondroitin, for example, in the case of chondroitin-containing shark cartilage extract containing 20% chondroitin (for example, SC20 manufactured by Maruha Nichiro Foods, Inc.) It can be determined as a guide that the daily dose is 1 to 3000 mg, preferably 50 to 1000 mg. For example, in the case of SC20 manufactured by Maruha Nichiro Foods, the amount of chondroitin is usually 0.02 to 99% by mass, preferably 0.5 to 70% by mass, based on the total mass of the powdered beverage composition. More preferably, it is 4-50 mass%.

(hyaluronic acid)
Hyaluronic acid is a macromolecular long-chain polysaccharide composed of disaccharide repeating units of D-glucuronic acid and N-acetyl-D-glucosamine. The average molecular weight of hyaluronic acid that can be used as the component (A) of the present invention is defined as a value determined by the following method.

  When the molecular weight of hyaluronic acid is about 800,000 to 2,000,000, about 0.05 g of hyaluronic acid is measured, and when the molecular weight of hyaluronic acid is about 500,000 to 800,000, about 0.1 g of hyaluronic acid is measured. Then, the weighed hyaluronic acid is dissolved in a 0.2 mol / l sodium chloride solution to prepare a solution exactly 100 ml. 8 ml, 12 ml and 16 ml are accurately weighed from the prepared solutions, and 0.2 mol / l sodium chloride solution is added to each to make exactly 20 ml. This sample solution and 0.2 mol / l sodium chloride solution were measured at 30.0 ± 0.1 ° C according to the Japanese Pharmacopoeia (17th revision) general test method viscosity measurement method (first method capillary viscosity measurement method). The specific viscosity is measured, and the reduced viscosity at each concentration is calculated. Draw a graph with the reduced viscosity on the vertical axis and the concentration (g / 100 ml) of the product converted to dry matter on the horizontal axis, and obtain the intrinsic viscosity from the intersection of the straight line connecting each point and the vertical axis. The intrinsic viscosity obtained here is substituted into Laurent's formula to calculate the average molecular weight.

Formulas for calculating specific viscosity, reduced viscosity, and Laurent's formula are shown below.
Specific viscosity = [(required flow time of sample solution) / (required flow time of 0.2 mol / l sodium chloride solution)]-1
Reduction limit = specific viscosity / (concentration of the product in terms of dry matter (g / 100 ml))
Intrinsic viscosity = 3.6 × 10 ⁻⁴ M ^0.78
M: average molecular weight

  The hyaluronic acid used as the component (A) of the present invention is preferably high molecular weight hyaluronic acid, more preferably hyaluronic acid having an average molecular weight of about 100,000 to 2 million, and an average molecular weight of about 600,000. More preferably, ˜1.2 million hyaluronic acid is used. Hyaluronic acid is not limited to having a single molecular weight, and may be a mixture having different molecular weights.

  The hyaluronic acid that can be used as the component (A) of the present invention basically has 50 disaccharide units in which the 1-position of β-D-glucuronic acid and the 3-position of β-DN-acetyl-glucosamine are bonded. Those containing more than one unit and those derivatives such as those having a hydrolyzable protecting group such as an acyl group can also be used. The sugar may be an unsaturated sugar, and examples of the unsaturated sugar include non-reducing terminal sugars, usually those having unsaturated carbon atoms between positions 4 and 5 of glucuronic acid.

  Hyaluronic acid may be extracted from natural products such as animals (for example, biological tissues such as chicken crowns, umbilical cords, skin, joint fluid, etc.), and those obtained by culturing microorganisms (for example, bacteria of the genus Streptococcus) Fermentation method used), chemically or enzymatically synthesized ones can be used.

  From the hyaluronic acid, the desired hyaluronic acid can be obtained by decomposing and / or purifying the hyaluronic acid, if necessary, using any known method. The hyaluronic acid used in the present invention may be in the form of a pharmacologically acceptable salt. Examples include alkali metal salts such as sodium salt and potassium salt; alkaline earth metal salts such as calcium salt and magnesium salt; amine salts such as tri (n-butyl) amine salt, triethylamine salt, pyridine salt and amino acid salt. It is done.

  A commercially available product may be used as hyaluronic acid. For example, the product names hyaluronic sun HA-F (average molecular weight 800,000, manufactured by Kewpie) and hyabest (J) (average molecular weight 800,000, manufactured by Kewpie) are listed.

  The blending amount of hyaluronic acid can be determined with reference to the intake amount of hyaluronic acid being 10 to 3000 mg, preferably 50 to 1000 mg per day per adult. The blending amount of hyaluronic acid is usually 0.02 to 99% by mass, preferably 0.5 to 70% by mass, more preferably 4 to 50% by mass, based on the total mass of the powder beverage composition. It is.

[1-2. (B) component]
The component (B) is 3-hydroxyisovaleric acid (3-Hydroxy-3-MethylButylate, β-Hydroxy-β-Methylbutyrate) and / or a salt thereof, and is a metabolite of leucine. It is also used as a muscle care material that is effective in increasing muscle mass and strength, and is classified as a food.

  The salt of 3-hydroxyisovaleric acid may be a salt that can be described as a food. For example, inorganic acid salts such as hydrochloride, hydrobromide, sulfate, hydroiodide, nitrate, phosphate; citrate, oxalate, acetate, formate, propionate, benzoate Acid salt, trifluoroacetate salt, maleate salt, tartrate salt, methanesulfonate salt, benzenesulfonate salt, paratoluenesulfonate salt, etc .; sodium salt, potassium salt, calcium salt, magnesium salt, ammonium salt Inorganic base salts such as salts; organic base salts such as triethylammonium salt, triethanolammonium salt, pyridinium salt and diisopropylammonium salt; amino acid salts such as arginine, aspartic acid and glutamic acid. Among these, inorganic base salts are preferable, and calcium salts are more preferable.

HMB may be derived from natural products, may be artificially produced, may be produced by genetic recombination, or may be a commercially available product. Also. The HMB may be a combination of two or more obtained by various acquisition methods.
A commercially available product may be used as the HMB. As a commercial item, product name HMB Kyowa (made by Kyowa Hakko Bio Co., Ltd.) and Kobayashi HMB powder (made by Kobayashi Fragrance Co., Ltd.) are mentioned, for example.

The amount of HMB blended can be determined based on the amount of HMB intake per adult being 100 to 5000 mg, preferably 500 to 3000 mg per day.
The compounding quantity of HMB is 0.99-99 mass% normally based on the total mass of a powdered drink composition, Preferably it is 9-99 mass%, More preferably, it is 15-91 mass%. Moreover, mass ratio ((A) / (B)) of (A) component with respect to HMB is 0.01-100 normally, Preferably it is 0.01-2, More preferably, it is 0.1-1 More preferably, it is 0.1-0.5.

[1-3. (C) Component]
(C) A component is at least 1 sort (s) selected from the group which consists of glucosamine and / or its salt, and collagen. Among the components (C), glucosamine is effective in maintaining an anti-inflammatory action and the amount of proteoglycan constituting the joint, and the powdered beverage composition containing glucosamine is a functional food that reduces pain in the knee joint. Can also be used. Collagen is a component constituting cartilage, has high water absorption, and can further enhance the function of improving the cushioning properties of the knee joint that the powdered beverage composition of the present invention crawls as a functional food.

(Glucosamine)
The glucosamine that can be used as the component (C) of the present invention may be a glucosamine derivative in which one or more of the hydrogen atoms contained in the structure thereof are substituted with other substituents. Preferably there is. As glucosamine, a pharmacologically acceptable salt thereof may be used. Glucosamine and pharmacologically acceptable salts thereof are industrially obtained by hydrolysis using, for example, chitin as a raw material, but those chemically synthesized or mixtures thereof can also be used. In addition to purified glucosamine, any component containing glucosamine as a component can be used.

  A commercially available product may be used as glucosamine. Examples of commercially available products include product name Green Grown (fermented glucosamine) (manufactured by Fight Pharma) and fermented glucosamine K (manufactured by Kyowa Hakko Bio).

The amount of glucosamine can be determined based on the fact that the intake of glucosamine is 100 to 5000 mg, preferably 500 to 3000 mg per day per adult.
The blending amount of glucosamine is preferably 8 to 50% by mass, more preferably 20 to 35% by mass, based on the total mass of the powdered beverage composition.

(collagen)
The collagen that can be used as the component (C) of the present invention may be any of types I to IV, and may be other collagens such as collagen peptides. It can also be prepared from animals such as cows, pigs, and chickens. In the present invention, collagen that can be used as the component (C) excludes collagen contained as other components, for example, collagen contained in chondroitin-containing shark cartilage extract.

  As collagen, you may use a commercial item. As a commercial item, product name Type-IP (made by Nitta Gelatin) and collagen (made by Nippi) are mentioned, for example.

The amount of collagen to be added can be determined on the basis that the intake amount of collagen is 1 to 1000 mg, preferably 5 to 20 mg per day per adult.
The amount of collagen is preferably 0.2 to 50% by mass, more preferably 4 to 20% by mass, based on the total mass of the powdered beverage composition.

  The mass ratio of component (A) to the total amount of component (C) and component (B) ((A) / ((B) + (C))) is usually in the range of 0.01 to 10, and 0 It is preferably in the range of 0.09 to 1, more preferably in the range of 0.3 to 1.

[1-4. Optional ingredients]
The powdered beverage composition of the present invention may contain other optional components as long as the effects and functions of the present invention are not impaired. For example, silicon dioxide such as hydrous silicon dioxide, light anhydrous silicic acid, heavy anhydrous silicic acid, crystalline cellulose, carmellose, carmellose calcium, carmellose sodium, croscarmellose sodium, carboxymethyl cellulose calcium, low substituted hydroxypropyl cellulose, Cross shaping agents such as crospovidone, lactose, corn starch, talc, powdered sugar, mannitol, dextrin; sweetness such as sucrose, sugar, honey, glucose fructose liquid sugar, glucose, licorice (glycyrrhizin), fructose, thaumatin, maltose, brown sugar Materials: Organic acids for food such as citric acid, lactic acid, malic acid, tartaric acid, succinic acid, gluconic acid, sodium salts such as citrate, lactate, malate, succinate, calcium salt, potassium salt, PH adjusters such as carbonates; dibutylhydroxytolue , Synthetic antioxidants such as butylhydroxyanisole, erythorbic acid, EDTA, sodium sulfite, sodium bisulfite; carotenoids such as carotene, lycopene, lutein, zeaxanthin; vitamin A, vitamin B, vitamin C (ascorbic acid), vitamin E ( Antioxidant vitamins such as tocopherol and tocotrienol; Flavonoids such as catechin and isoflavone; Antioxidants such as polyphenols or their derivatives and rosemary extract; Medicinal components such as aloe juice, Achacharu and ginseng; Fruit juices such as apple juice, plum juice, mandarin juice, grapefruit juice; and flavors such as apple flavor, plum flavor, tangerine flavor, grapefruit flavor and the like.

[2. Fluidity improver, solubility improver]
The fluidity improver of the present invention and the solubility improver of the present invention are application inventions of the above-described powder beverage composition of the present invention. Therefore, even if it is a powdered beverage containing the component (A) that is inferior in fluidity and solubility, it contains the component (B) that can be displayed as a food, so that it has not been favored by consumers in the past. However, problems such as poor mixing and poor solubility can be solved without using additives that display food additives.
The other details are the same as those described in “1. Powdered beverage composition” above.

[3. Method]
The method of the present invention is a method for improving at least one of fluidity and solubility of a composition containing at least one of component (A): chondroitin and hyaluronic acid, and component (B): 3-hydroxy This is a method of adding isovaleric acid and / or a salt thereof.
It does not specifically limit as a form which adds (B) component to the composition containing (A) component. For example, the form in which the component (B) of the powder is added to the powder composition, the form in which the powder of the other component is added to the liquid (aqueous solution, alcohol solution, slurry, etc.) of any component, and the liquid (aqueous solution) of any component , Alcohol solutions, slurries, and the like). However, when liquid is used, drying is performed.
The other details are the same as those described in “1. Powdered beverage composition” above.

  Hereinafter, the present invention will be described in detail with reference to examples. The following examples are for explaining the present invention preferably and are not intended to limit the present invention. In addition, unless otherwise indicated, the measuring methods, such as a physical-property value, are the measuring methods described above. “Part” means part by mass.

[Fluidity evaluation (repose angle evaluation)]: According to the 17th revised Japanese Pharmacopoeia Manual, the angle of the powder crest (repose angle) was measured with the sample naturally dropped by the injection method. A 10 g sample was dropped from a fixed funnel onto a disk having a diameter of 15 cm, and the angle of repose was calculated from the height of the resulting cone and the diameter of the disk. The height of the lower end of the funnel leg was set to be about 4 cm from the top of the deposit. The lower the angle of repose, the better the fluidity.

[Evaluation of fluidity (visual evaluation)]: 5 g of the blended sample was placed in a glass bottle, the powder was moved in the bottle by changing the inclination of the glass bottle, and the fluidity was evaluated visually. The criteria are shown below.
◎: Very good ○: Good ●: Slightly good ×: Bad

[Solubility Evaluation]: 200 mL of water (25 ° C.) was put into a 300 mL beaker, 2.5 g of a sample was added, and the mixture was stirred at 500 rpm using a magnetic stirrer, and the time until dissolution or dispersion was measured. The criteria are shown below.
◎: Within 1 minute ○: Within 2 minutes ●: Within 5 minutes ×: Insoluble

The components used in the following Examples, Comparative Examples and Formulation Examples are described below.
HMB calcium (trade name “HMB Kyowa”, manufactured by Kyowa Hakko Bio)
Chondroitin-containing shark cartilage extract (trade name “SC20”, manufactured by Maruha Nichiro Foods)
Hyaluronic acid (trade name “Hear Best J”, manufactured by Kewpie)
Glucosamine (trade name “Green Grown”, manufactured by Fight Pharma)
Collagen (Nippi)
Crystalline cellulose (trade name “Theolas UF-F711”, manufactured by Asahi Kasei Corporation)

Example 1
100 parts of chondroitin-containing shark cartilage extract and 1 part of HMB calcium were mixed, placed in a transparent bottle, and allowed to stand at 40 ° C. and 75% relative humidity for 3 days. This powder was used for fluidity evaluation and solubility evaluation. The evaluation results are shown in Table 1.

(Examples 2 to 21)
Fluidity evaluation and solubility evaluation were performed in the same manner as in Example 1 except that the type of component (A) and the blending amounts of component (A) and component (B) were changed as shown in Table 1. The evaluation results are shown in Table 1.

(Comparative Examples 1-4)
Each component was changed to the formulation shown in Table 2, placed in a transparent bottle, and allowed to stand for 3 days at 40 ° C. and 75% relative humidity. This powder was used for fluidity evaluation and solubility evaluation. The evaluation results are shown in Table 2.

From Table 2, when the chondroitin-containing shark cartilage extract and hyaluronic acid are used alone as the component (A) (Comparative Examples 1 and 2), the chondroitin-containing shark cartilage extract and hyaluronic acid are used as the component (A). It can be seen that the evaluation results of fluidity and solubility are poor when each is used in combination with crystalline cellulose (Comparative Examples 3 and 4).
On the other hand, from Table 1, the powdered beverage composition of the present invention containing the component (A) using the chondroitin-containing shark cartilage extract and the component (B) capable of displaying food has improved fluidity and solubility. (Examples 1-8). Moreover, when it examined using hyaluronic acid as (A) component, fluidity | liquidity and solubility improved to about the same extent (Examples 9-13). Furthermore, even when the chondroitin-containing shark cartilage extract and hyaluronic acid were used in combination as the component (A), fluidity and solubility were improved (Examples 14 to 21).

(Examples 22 to 33)
Each component was changed to the formulation shown in Table 3, placed in a transparent bottle, and allowed to stand for 3 days at 40 ° C. and a relative humidity of 75%. This powder was used for fluidity evaluation and solubility evaluation. The evaluation results are shown in Table 3.

  From Table 3, the powdered beverage of the present invention containing (C) component in addition to (B) component which can be labeled as (A) component and chondroitin-containing shark cartilage extract, hyaluronic acid, or a mixture thereof It can be seen that the compositions (Examples 22 to 33) have significantly improved fluidity. Moreover, it turns out that the effect of a solubility improvement is improved irrespective of a compounding ratio.

(Prescription Examples 1 to 3)

Details of the optional ingredients used in the formulation examples are described.
Dextrin (trade name “Paindex 100”, manufactured by Matsutani Chemical Industry Co., Ltd.)
Citric acid (Brand name "Citric acid", manufactured by Iwata Kagaku Kogyo Co., Ltd.)
Sucrose (trade name “Sucrose”, manufactured by Wako Pure Chemical Industries, Ltd.)

Claims (10)

(A) Component: Powdered beverage composition containing at least one of chondroitin and hyaluronic acid, and (B) component: 3-hydroxyisovaleric acid and / or a salt thereof.   The powdered beverage composition according to claim 1, wherein the chondroitin in the component (A) is chondroitin contained in a chondroitin-containing shark cartilage extract.   (C) Component: The powder drink composition of Claim 1 or 2 which further contains at least 1 sort (s) selected from the group which consists of glucosamine and / or its salt, and collagen. (A) Component: A fluidity improver containing at least one of chondroitin and hyaluronic acid, and (B) component: 3-hydroxyisovaleric acid and / or a salt thereof. (A) Component: A solubility improver containing at least one of chondroitin and hyaluronic acid, and (B) component: 3-hydroxyisovaleric acid and / or a salt thereof.   The agent according to claim 4 or 5, wherein the chondroitin in the component (A) is chondroitin contained in a chondroitin-containing shark cartilage extract.   (C) Component: The agent of any one of Claims 4-6 which further contains at least 1 sort (s) selected from the group which consists of glucosamine and / or its salt, and collagen. (A) component: a method for improving at least one of fluidity and solubility of a composition containing at least one of chondroitin and hyaluronic acid,
Component (B): A method of adding 3-hydroxyisovaleric acid and / or a salt thereof.   The method according to claim 8, wherein the chondroitin in the component (A) is chondroitin contained in a chondroitin-containing shark cartilage extract.   The method according to claim 8 or 9, wherein the composition further comprises (C) component: glucosamine and / or a salt thereof, and at least one selected from the group consisting of collagen.