JP2018139733A - Skin-patching adhesive patch and its manufacturing method - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide means for prevention adhesive deposit in the peeling from skin while securing gas permeability being basic properties as a skin-patching adhesive patch.SOLUTION: A skin-patching adhesive patch is provided by laminating an adhesive layer on a gas permeability support. The skin-patching adhesive patch is characterized in that the pressure-sensitive adhesives constituting the adhesive layer are emulsion type pressure-sensitive adhesives, and many fine upper and lower through-holes penetrating through the adhesive layer in the thickness direction are formed over the entire surface of the adhesive layer.SELECTED DRAWING: Figure 1

Description

  The present invention relates to a skin patch and a method for producing the same.

  It is desirable that the adhesive material to be applied to human skin such as a bandage, a dressing film, and a taping tape has high air permeability.

  In order for the patch to have such characteristics, it is necessary to increase the air permeability of the pressure-sensitive adhesive layer together with the support. Here, as the pressure-sensitive adhesive constituting the pressure-sensitive adhesive layer, an emulsion-type pressure-sensitive adhesive using water as a medium is suitably used for environmental protection. As a means for foaming the emulsion-type pressure-sensitive adhesive to increase the air permeability of the pressure-sensitive adhesive layer, mechanical foaming (aeration mixing) is generally performed (for example, Patent Document 1).

Prior patent documents

JP 2004-84138 A

  However, the patch described in Patent Document 1 has a problem in that it tends to cause residue when peeled from the skin. Then, an object of this invention is to provide the means which prevents the residue at the time of peeling from skin, ensuring the high air permeability which is a basic characteristic as a patch for skin sticking.

The present invention (1) is a skin patch, in which an adhesive layer is laminated on a support,
The pressure-sensitive adhesive constituting the pressure-sensitive adhesive layer is an emulsion-type pressure-sensitive adhesive, and a large number of fine upper and lower through holes penetrating the pressure-sensitive adhesive layer in the thickness direction are formed over the entire surface of the pressure-sensitive adhesive layer. It is a characteristic patch.
The present invention (2) is the adhesive material according to the invention (1), wherein an average hole diameter of the fine upper and lower through holes is 20 to 400 μm.
The present invention (3) is the patch of the invention (1) or (2), wherein the shape of the fine upper and lower through holes is a columnar shape.
The present invention (4), the surface density of the fine vertical through hole in the adhesive layer surface of the adhesive layer is a 2 to 100 / mm ^2, in patch of the invention (1) to (3) is there.
The present invention (5) is the adhesive material according to any one of the inventions (1) to (4), wherein an opening area ratio of the fine upper and lower through holes with respect to the pressure-sensitive adhesive layer surface area is 3 to 40%.
The present invention (6) is the patch according to any one of the inventions (1) to (5), wherein the air permeability of the patch is 0.1 to 30 sec / 100 ml.
The present invention (7) is a skin patch, in which an adhesive layer is laminated on a support,
The pressure-sensitive adhesive layer has pores formed by decomposing the foaming agent in a state where an emulsion-type pressure-sensitive adhesive liquid containing a foaming agent is applied on a peelable sheet having a fine uneven shape. It is a characteristic patch.
In the invention (8), the peelable sheet has irregularities having an arithmetic average roughness of 0.5 to 3.0 μm and an average length of the roughness curved surface element of 0.05 to 0.20 mm on the surface. 7) A patch.
The present invention (9) is a method for producing a skin patch, wherein a pressure-sensitive adhesive layer is laminated on a support.
It is a manufacturing method characterized by including the process of forming a hole by applying the emulsion type adhesive liquid containing a foaming agent on the peelable sheet which has fine uneven | corrugated shape, and decomposing | disassembling the said foaming agent.
In the invention (10), the peelable sheet has irregularities having an arithmetic average roughness of 0.5 to 3.0 μm and an average length of the roughness curved surface element of 0.05 to 0.20 mm on the surface. 9) The production method.
This invention (11) is a manufacturing method of the said invention (9) or (10) whose surface tension of the said emulsion type adhesive liquid is 35 mN / m or less.
This invention (12) is a manufacturing method of said invention (9)-(11) whose said patch for skin patches is the patch for skin patches of said invention (1)-(6).

  ADVANTAGE OF THE INVENTION According to this invention, it becomes possible to provide the means which prevents the residue at the time of peeling from skin, ensuring the high air permeability which is the basic characteristic as a patch for skin sticking. Furthermore, according to the more preferable present invention, air permeability, sweat discharge, water resistance, and administration of a drug on the affected skin surface by applying a drug solution to the surface of the patch can be secured. In general, when the cohesive force is increased in order to prevent adhesive residue, the adhesive strength is reduced and the adhesion to the skin is significantly reduced. However, according to the present invention, it can also be prevented.

FIG. 1 is a perspective view of an adhesive patch for skin application according to the present invention (an example). FIG. 2 is a top view of the skin patch according to the present invention (an example). FIG. 3 is a cross-sectional view of an adhesive patch for skin application according to the present invention (an example). FIG. 4 is a surface state diagram (one example) by a surface roughness measuring instrument of a peelable sheet having irregularities on the surface when producing a skin patch according to the present invention.

Hereinafter, the patch for skin patch according to the present invention will be described in the following order.
1. 1. Overall structure and physical properties of the skin patch. Each part 2-1. Adhesive layer 2-1-1. Structure of adhesive layer 2-1-2. Material of adhesive layer 2-1-3. Physical properties of pressure-sensitive adhesive layer 2-2. 2. Air-permeable support 3. Method for producing skin patch material 3-1. Raw materials / used members 3-2. Process 4. Usage (application) of skin patch

<< 1. Overall structure and properties of skin patch materials >>
As shown in FIG. 1 to FIG. 3, a patch 1 for skin patch according to the present invention constitutes the pressure-sensitive adhesive layer 1 </ b> A in a patch for skin patch in which a pressure-sensitive adhesive layer 1 </ b> A is laminated on a support 1 </ b> B. The pressure-sensitive adhesive is an emulsion-type pressure-sensitive adhesive, and a large number of fine upper and lower through holes 1Aa penetrating the pressure-sensitive adhesive layer 1A in the thickness direction are formed over the entire surface of the pressure-sensitive adhesive layer 1A. It is a patch. In addition, although not shown in figure, even if the peeling layer exists on the surface on the opposite side to the contact surface with the air-permeable support body 1B of the adhesive layer 1A, the patch 1 for skin sticking which concerns on this invention exists. (In addition, the release layer may be a peelable sheet used in the method for producing a patch for skin patch described below).

  The air permeability of the skin patch according to the present invention is preferably in the range of 0.1 to 30 sec / 100 ml, more preferably in the range of 0.1 to 20 sec / 100 ml, and particularly preferably. Is in the range of 0.1 to 10 sec / 100 ml.

<2. Each part>
{2-1. Each part / adhesive layer}
(2-1-1. Structure of each part / adhesive layer / adhesive layer)
Hereinafter, the structure of the pressure-sensitive adhesive layer will be described with reference to FIGS.

-Thickness First, the thickness of the pressure-sensitive adhesive layer 1A is preferably 5 to 100 µm, more preferably 10 to 80 µm, and particularly preferably 20 to 60 µm.

-Fine vertical through-holes A large number of fine vertical through-holes 1Aa penetrating the pressure-sensitive adhesive layer 1A in the thickness direction are formed over the entire surface of the pressure-sensitive adhesive layer 1A. Here, the fine vertical through hole refers to a cylindrical hole formed in the vertical direction with respect to the thickness direction of the pressure-sensitive adhesive layer. Here, the average hole diameter of the fine upper and lower through holes 1Aa is preferably 20 to 400 μm, more preferably 30 to 300 μm, and particularly preferably 40 to 200 μm. The shape of the through hole is preferably a columnar shape. In addition, as above-mentioned, a fine vertical through-hole is not specifically limited as long as it is a cylindrical hole (through-hole) formed in the up-down direction on the basis of the thickness direction of an adhesive layer, For example, it exists in an adhesive layer. It is not necessary for all of the fine upper and lower through holes to communicate from the surface of the pressure-sensitive adhesive layer to the gas-permeable support. Furthermore, the surface density (foaming density) of the fine upper and lower through holes 1Aa on the surface of the pressure-sensitive adhesive layer is preferably 2 to 100 / mm ² , more preferably 3 to 80 / mm ² , and particularly 4 to 60 / mm ² . ² is desirable. Furthermore, the opening area ratio (opening ratio) of the fine upper and lower fine holes with respect to the adhesive layer surface area is preferably 3 to 40%, more preferably 5 to 30%. Within these ranges, better pressure-sensitive adhesive air permeability and pressure-sensitive adhesive properties tend to be realized. Thus, in order to ensure the basic characteristics (permeability, etc.) of the skin patch, in the prior art, bubbles were generated in a spongy form by mechanical foaming (aeration agitation). Fine upper and lower through holes are formed over the entire surface of the layer. By adopting such a configuration (in addition to this, the use of an emulsion-type pressure-sensitive adhesive and the use of a gas-permeable support), the present inventors can not only realize the conventional basic characteristics but also at the time of peeling from the skin. It was found that an unexpected effect that the residue is significantly suppressed can be realized.

(2-1-2. Parts / Adhesive layer / Adhesive layer material)
As the emulsion-type pressure-sensitive adhesive according to the present invention, an acrylic pressure-sensitive adhesive is suitably used. Hereinafter, the emulsion type acrylic pressure-sensitive adhesive which is a preferred embodiment will be described in detail. In addition, in the following description, the description regarding the emulsion type adhesive liquid which is a raw material used for forming the said adhesive layer other than the description regarding the emulsion type acrylic adhesive which comprises an adhesive layer is also contained.

  Suitable emulsion-type acrylic pressure-sensitive adhesives include (meth) acrylic acid alkyl ester having 4 to 12 carbon atoms of alkyl group, 50 to 99.5% by weight, carboxyl group-containing monomer 0.5 to 10% by weight, and other An emulsion type acrylic system obtained by adding 0.3 to 12 parts by weight of a surfactant to 100 parts by weight of a mixed monomer containing 0 to 40% by weight of a copolymerizable monomer as a component and emulsion polymerization in an aqueous medium. It is an adhesive. Hereinafter, each raw material and polymerization method will be described in detail.

  First, the (meth) acrylic acid alkyl ester having 4 to 12 carbon atoms in the alkyl group is an ester of (meth) acrylic acid and an alcohol having 4 to 12 carbon atoms. Here, the alcohol may be linear or branched. Examples of the ester include butyl acrylate, 2-ethylhexyl acrylate, isooctyl acrylate, isononyl acrylate, decyl acrylate, and the like. Moreover, you may use 1 type or in combination of 2 or more types.

  Next, the carboxyl group-containing monomer is not particularly limited as long as it has at least one carboxyl group and has a C═C double bond. For example, (meth) acrylic acid, maleic acid, itaconic acid, acrylic acid Examples thereof include carboxyl group-containing monomers such as 2-carboxyethyl, 2-acryloylethylsuccinic acid, and acrylic acid ω-carboxypolycaprolactone. Moreover, you may use 1 type or in combination of 2 or more types.

  Other copolymerizable monomers include, for example, hydroxyl group-containing monomers such as 2-hydroxyethyl acrylate and 2-hydroxypropyl acrylate, amide monomers such as (meth) acrylamide and N-methylolacrylamide, styrene, vinyl acetate, and the like. Vinyl monomers, epoxy group-containing monomers such as glycidyl (meth) acrylate, nitrile monomers such as (meth) acrylonitrile, methyl acrylate, ethyl acrylate, isopropyl acrylate, stearyl acrylate, etc. Examples thereof include polyfunctional monomers such as (meth) acrylic acid alkyl ester, triethylene glycol diacrylate, neopentyl glycol diacrylate, and trimethylolpropane triacrylate. These monomers may be used alone or in combination of two or more.

  Surfactant as an emulsifier for emulsion polymerization is not particularly limited, and general ones can be adopted, specifically, polyoxyethylene alkylaryl ether, polyoxyethylene sorbitan fatty acid ester, etc. Nonionic surfactants, anionic surfactants such as fatty acid soaps, alkyl sulfonates, alkyl succinates, polyoxyethylene alkyl sulfates, alkyl trimethyl ammonium salts, dialkyl dimethyl ammonium salts, benzalkonium chloride And amphoteric surfactants such as alkyldimethylaminoacetic acid betaine, alkyldimethylamine oxide, and alkylcarboxymethylhydroxyethylimidazolium betaine.

  There is no restriction | limiting in particular regarding emulsion polymerization, A well-known method, conditions, etc. are applicable. For example, a mixed monomer, a polymerization initiator, and the like are added to ion-exchanged water in which a surfactant is dissolved, dispersed and emulsified with a high-speed stirrer, and then kept at a constant temperature of 50 to 95 ° C. and copolymerized in an inert atmosphere. Alternatively, a method may be used in which a part of the emulsion is polymerized and the remaining part is dropped continuously or intermittently for polymerization. The concentration of the surfactant with respect to the whole emulsion-type pressure-sensitive adhesive liquid is preferably 0.3 to 12% by weight, and the concentration of all monomers with respect to the whole emulsion-type pressure-sensitive adhesive liquid is preferably within the range of 30 to 70% by weight. To do. Examples of the polymerization initiator include persulfates such as ammonium persulfate and potassium persulfate, and water-soluble azo compounds such as azobiscyanovaleric acid. The polymerization initiator is preferably used in an amount of 0.01 to 5 parts by weight with respect to 100 parts by weight of all monomers.

  For the emulsion type adhesive liquid prepared as described above, if necessary, additives such as antifoaming agent, thickener, preservative, chain transfer agent such as butyl mercaptan, dodecyl mercaptan, tackifier resin, etc. May be added. Moreover, a polyfunctional compound can also be added later to the emulsion-type pressure-sensitive adhesive liquid as a crosslinking agent. Further, a water-soluble foaming agent is used as the foaming agent added to the emulsion-type pressure-sensitive adhesive liquid. Specifically, sodium hydrogen carbonate, ammonium hydrogen carbonate, ammonium carbonate and the like are preferably used. The final concentration of the solid content is preferably 30 to 70% by weight. The surface tension of the emulsion-type pressure-sensitive adhesive liquid is preferably 50 mN / m or less, and more preferably 35 mN / m or less. As a means for adjusting the surface tension, it is preferable to use a wetting agent. Examples of the wetting agent include sodium polyoxyethylene lauryl ether acetate, polyoxyalkylene alkyl ether, polyoxyethylene sorbitan fatty acid ester, sodium lauryl sulfate, sodium dioctyl sulfosuccinate and the like. Of these, sodium dioctyl sulfosuccinate is preferred. Examples of the crosslinking agent include oxazoline group-containing water-soluble polymers, oxazoline group-containing polymer emulsions, epoxy group-containing resin emulsions, and carbodiimide group-containing water-soluble polymers. As the thickener, urethane association type, acrylic acid polymer type or the like is preferably used.

{2-2. Each part / support}
Hereinafter, the structure of the support B will be described with reference to FIGS. The support for the patch of the present invention is not particularly limited, but preferably has good air permeability and / or moisture permeability. Here, the air permeability of the support is preferably in the range of 0.1 to 29 sec / 100 ml. The moisture permeability of the support (measured based on JIS L 1099 A-1 method (calcium chloride method)) is 3,000 g / m ² · day or more, and 4,000 g / m ² · day or more. preferable. The upper limit of the moisture permeability of the support is not particularly limited, but is usually about 10,000 g / m ² · day or less, preferably about 8,000 g / m ² · day or less. For example, an air-permeable base material such as a nonwoven fabric or a felt-like fiber assembly, a plastic film subjected to perforation processing, a porous plastic film having micropores, or the like is used. Examples of the material of the nonwoven fabric or felt-like fiber assembly include natural fibers such as cotton, hemp, silk, hair, and rayon, and synthetic fibers such as polyamide, polyester, polyethylene, polypropylene, polyacryl, and polyvinyl chloride. In addition, as a plastic film that has been perforated, for example, a small hole is formed in a plastic film (sheet) such as polyethylene, polypropylene, nylon, polyester, polyvinyl chloride, etc. with a needle, laser, electric discharge machining, etc. to give air permeability. Can be mentioned. At this time, a small hole of 0.1 μm to 10 μm is provided as an opening diameter, but is not limited to this range, and is set so as to obtain a predetermined air permeability. As the porous film, for example, a polyolefin resin such as polyethylene or polypropylene, or a fluorine resin such as polytetrafluoroethylene, and an inorganic filler such as calcium carbonate, particularly those having an average particle size of 30 μm or less are extruded. What was made into a film by an appropriate method such as uniaxially or biaxially is used to make a porous film. Moreover, as a highly moisture permeable film, a polyurethane film can also be used as it is, for example. In the case of a polyurethane film, the structure of the main chain may be a polyether type or a polyester type. In this case, it is difficult to administer the drug to the affected skin surface by applying the drug solution to the surface, but a patch with excellent moisture permeability can be obtained. Moreover, when a nonwoven fabric is used as the support, those having a basis weight (basis weight) of about 10 to 200 g / m ² are preferably used. Moreover, when using a plastic film, that whose thickness is about 10-200 micrometers is used preferably. Furthermore, in the present invention, these supports can be used as a single layer, or a laminate in which different permeable supports are laminated.

<3. Manufacturing method of skin patch material>
(3-1. Raw materials and materials used)
Since the emulsion-type adhesive liquid and the air-permeable support among the raw materials and the used members used in the production of the skin patch according to the present invention have been described above, the peelable sheet as the used member will be described below. . The peelable sheet is used in a manner described in the following process. The peelable sheet is obtained by surface-treating a release agent (for example, silicone resin) on a base material. Here, the surface of the peelable sheet needs to be uneven. The irregularities preferably have an arithmetic average roughness (Ra) of 0.5 to 3.0 μm, and more preferably 0.8 to 2.0 μm. Moreover, the average length (RSm) of a roughness curved surface element is 0.05-0.20 mm, More preferably, it is 0.07-0.18 mm. The substrate is preferably made of paper. Of these, fine paper and glassine paper are preferred. Here, the fine paper refers to a western paper having a chemical pulp content of 100%. In the present invention, the high-quality paper is preferably of a type in which clay, resin emulsion, or polyvinyl alcohol (PVA) is surface-treated, capable of direct silicone treatment. Glassine paper is obtained by making paper using chemical pulp that has been subjected to a high level of beating treatment, and further densifying it with finishing equipment such as a super calender. Here, the reason why it is considered that when the peelable sheet is used, fine vertical through holes extending in the thickness direction can be formed. First, when the pressure-sensitive adhesive liquid is warmed on the peelable sheet, the foaming agent is decomposed and small bubbles are generated. Here, in order to form a large through-hole, it is necessary for the small bubbles to coalesce. When a peelable sheet with moderate unevenness (Ra) is used, the bubbles are merged using the concave portion as a scaffold. It is understood that they are united (unified in the vertical direction) In addition, it is understood that lateral coalescence (related to hole diameter) is related to RSm. In the case of a moderate Ra, the concave portion may not be used as a scaffold, but in this case, when the surface tension is lowered, the adhesive liquid tends to infiltrate into the concave portion and is easily affected by the unevenness. Therefore, it is understood that the coalescence of bubbles proceeds. On the other hand, in the case of a releasable sheet with low Ra and no undulation, there is no scaffolding in the first place, so it is presumed that even if the surface tension is lowered, the coalescence of bubbles does not progress and a through hole cannot be formed.

(3-2. Process)
Hereinafter, an example of the manufacturing process of the patch for skin patch according to the present invention will be described. The coater (sheet feeding unit, coater head, heating drying unit, winding unit is arranged in this order in a straight line, and the second sheet feeding unit is located above the winding unit, and the heating drying unit and winding unit. The emulsion-type pressure-sensitive adhesive solution polymerized on the peelable sheet that has been fed out is applied at a predetermined thickness with a coater head, and then heated to 80 to 130 ° C. in a heating and drying unit. A hot air of a certain degree is blown onto the coated surface (and / or by bringing the back side of the peelable sheet into contact with a Yankee dryer), and at the same time, the foaming agent is thermally decomposed to generate gas to form a pressure-sensitive adhesive layer having through holes. Next, the support sheet fed from the second sheet feeding unit is bonded to the pressure-sensitive adhesive surface via a laminating roll, and wound up by the winding unit. In this case, a release agent such as a silicone resin or a long-chain alkyl group-containing polymer is treated on a surface different from the surface to be bonded to the adhesive in advance, and the release sheet is peeled and removed again after lamination. The support on which the agent is transferred and laminated may be wound up as it is. The wound raw material is rolled into a suitable thin roll by a cutting machine, or the unraveled sheet is cut into an appropriate shape to obtain a patch.

<4. Usage of skin patch (application)>
The usage method (use) of the skin patch will be described. The patch for skin application according to the present invention is used for application to human skin. For example, a bandage, a dressing film, a taping tape, a transdermal absorption preparation, and a surgical tape can be mentioned.

  Hereinafter, the present invention will be specifically described with reference to examples. The present invention is not limited to the following examples. Unless otherwise specified, parts and% mean parts by mass (parts by weight) and mass% (% by weight).

≪Production example≫
<Example 1>
(Preparation of emulsion type adhesive liquid)
Charged ion exchange water and chain transfer agent n-octyl-3-mercaptopropionate into a temperature-controllable reaction vessel equipped with a thermometer, condenser, nitrogen inlet tube, and stirrer. The temperature was raised to 66 ° C., and a solution prepared by dissolving 0.25 parts of ammonium persulfate as a polymerization initiator in ion-exchanged water was added dropwise. After 10 minutes, 98 parts of 2-ethylhexyl acrylate and 2 parts of acrylic acid were used. A monomer emulsion obtained by emulsifying and dispersing the monomer mixture in 3 parts of polyoxyethylene alkylsulfate and ion-exchanged water was continuously added in 3.5 hours, and the reaction was further continued at 66 ° C. for 2 hours. After completion, it was cooled. Filtration through a wire mesh or the like gave an acrylic copolymer emulsion pressure-sensitive adhesive liquid (A) having a solid content of 50%. In addition, the other emulsion polymer used by the present Example and the comparative example was manufactured according to the said manufacture example, and was used.
(Coating process)
In the adhesive liquid (A), 5% by weight of ammonium hydrogen carbonate, 0.75% by weight of a crosslinking agent, 1% by weight of a thickener, 2% by weight of a neutralizing agent are added and stirred with respect to the total amount of monomers. And it was set as the coating liquid. Thereafter, a peelable sheet (K8 Siro E (R0): Lintec Co., Ltd.) whose base material is PVA-treated fine paper is fed out from the first feeding portion with a coater, and the application amount after drying is 38 g / min with a comma coater. Apply the coating liquid with a certain thickness to m ² and dry it in the heating and drying box of the next process. At the same time, decompose the foaming agent, generate gas, provide through-holes in the adhesive layer, and dry A polyester nonwoven fabric (air permeability: 0.2 sec / 100 ml) fed from the second feeding section when it comes out of the box is bonded to the adhesive surface via a laminating roll, wound up at the winding section, and supported / adhesive. An original sample consisting of three layers of agent / peelable sheet was used.
(Preparation of patch)
The original sample was aged for 3 days in an atmosphere of 40 ° C., then cut into a certain size and shape, and subjected to each test.
<Example 2>
The patch according to Example 2 was produced in the same manner as in Example 1 except that the peelable sheet (78EVS (M): Oji F-Tex Co., Ltd.) with different Ra and RSm was used.
<Example 3>
The patch according to Example 3 was produced in the same manner as in Example 1 except that the base material of the peelable sheet was changed to glassine paper (64GSM-L: Oji F-Tex Co., Ltd.).
<Example 4>
The patch according to Example 4 was prepared in the same manner as in Example 3 except that 1% by weight of sodium dioctylsulfosuccinate was added to the emulsion-type pressure-sensitive adhesive liquid (A) and stirred. .
<Comparative Examples 1 and 2>
Comparative Examples 1 and 2 were the same as in Example 4 except that the base material of the peelable sheet was changed to polyrami fine paper (80EPS: Oji F-Tex Co., Ltd.) and polyester film (film binder: Fujimori Kogyo Co., Ltd.). It produced similarly.
<Comparative Example 3>
Comparative Example 3 was prepared in the same manner as Comparative Example 2, except that the foaming agent was not added to the emulsion-type pressure-sensitive adhesive liquid (A), and the liquid was vigorously stirred with a homomixer and then foamed.

≪Evaluation≫
<Test method>
(A. Surface tension of adhesive liquid)
The surface tension was measured at normal temperature and normal pressure using a Wilhelmy automatic surface tension meter (manufactured by KRUSS).
(B. Release sheet)
1. Arithmetic average roughness (Ra: JIS B 0601)
The surface roughness was measured using a surf coder (manufactured by Kosaka Laboratory Ltd.) at a Z magnification of 10,000. Leveling was the least square method, and the pitch was 10 μm.
2. Average length of roughness curved surface element (RSm: JIS B 0601)
An arbitrary XZ plane was taken out from the data measured above, RSm was measured, 10 planes were measured in the Y direction, and average values were obtained (refer to FIG. 4 for X, Y, and Z axes).
(C. Through-hole of adhesive layer)
1. An enlarged photograph of the pressure-sensitive adhesive surface was taken with an average hole diameter electron microscope, and the diameter of the through hole in this image was read using image analysis software, and the average value of the diameters of all the through holes on the image was determined. In addition, when the hole shape was not a perfect circle, the longest part was made into the diameter.
2. Foam density The number of through-holes in a 1 mm × 1 mm square selected at random in the above enlarged photograph was read.
3. Hole area ratio The above enlarged photograph was read using image software, and the area of the through hole / the area of the patch was determined.
(D. Support)
1. Air permeability The same as the method described in E below (E. patch)
1. The air permeability was measured using a Gurley type densometer (manufactured by Tester Sangyo Co., Ltd.) based on JIS P 8117. The sample which cut | judged to the magnitude | size of 50 mm x 50 mm and removed the peelable sheet was prepared, and it affixed on the clamping board (base). The area that passes through the clamping plate has an area of 642 mm ² . Pull out the inner cylinder, set it on the stopper, and tighten the specimen between the clamping plates. The inner cylinder was gently lowered and the number of seconds (sec) through which 100 ml of air passed was measured. A: 0.1 seconds or more and less than 10 seconds O: 10 seconds or more and less than 30 seconds X: 30 seconds or more A small amount of the drug-permeable drug (ointment and cream) was taken on the fingertip, and the sample piece was applied from the back side of the sample with the sample piece suspended in the air, and the state and amount of the drug that permeated out were visually confirmed. Judgment was made according to the following criteria. ◯: Sufficiently transmitted Δ: Transmitted to some extent ×: Almost not transmitted Adhesive strength (water resistance)
A sample cut to 15mm x 75mm is attached in the forearm inner part of the same person in close proximity with 4 to the right arm and 3 to the left arm. And peeling at a speed of 100 mm / min and an angle of 90 °. ◯: The sample does not peel off and does not float, and the adhesive strength is 0.5 N / 15 mm or more. X: The sample peels off or floats, and the adhesive strength is less than 0.5 N / 15 mm. At the time of measuring the adhesive strength of the adhesive residue, the presence or absence of the adhesive remaining after peeling to the skin as the adherend was determined by visual observation and finger tack.
<Evaluation results>
Table 1 shows the evaluation results.

Claims (12)

In the patch for skin patching in which the adhesive layer is laminated on the support,
The pressure-sensitive adhesive constituting the pressure-sensitive adhesive layer is an emulsion-type pressure-sensitive adhesive, and a large number of fine upper and lower through holes penetrating the pressure-sensitive adhesive layer in the thickness direction are formed over the entire surface of the pressure-sensitive adhesive layer. Characteristic patch material.   The patch according to claim 1, wherein an average hole diameter of the fine upper and lower through holes is 20 to 400 μm.   The patch according to claim 1 or 2, wherein a shape of the fine upper and lower through holes is a columnar shape. The surface density of the fine vertical through hole in the adhesive layer surface of the adhesive layer is 2 to 100 / mm ^2, the adhesive material of any one of claims 1 to 3.   The patch according to any one of claims 1 to 4, wherein an opening area ratio of the fine upper and lower through holes with respect to a surface area of the pressure-sensitive adhesive layer is 3 to 40%.   The patch according to any one of claims 1 to 5, wherein the air permeability of the patch is 0.1 to 30 sec / 100 ml. In the patch for skin patching in which the adhesive layer is laminated on the support,
The pressure-sensitive adhesive layer has pores formed by decomposing the foaming agent in a state where an emulsion-type pressure-sensitive adhesive liquid containing a foaming agent is applied on a peelable sheet having a fine uneven shape. Characteristic patch material.   The patch according to claim 7, wherein the peelable sheet has irregularities having an arithmetic average roughness of 0.5 to 3.0 μm and an average length of the roughness curved surface element of 0.05 to 0.20 mm on the surface. In the method for producing a patch for skin patching in which an adhesive layer is laminated on a support,
The manufacturing method characterized by including the process of forming a hole by applying the emulsion-type adhesive liquid containing a foaming agent on the peelable sheet which has a fine uneven | corrugated shape, and decomposing | disassembling the said foaming agent.   The manufacturing method according to claim 9, wherein the peelable sheet has irregularities having an arithmetic average roughness of 0.5 to 3.0 μm and an average length of the roughness curved surface element of 0.05 to 0.20 mm on the surface.   The manufacturing method of Claim 9 or 10 whose surface tension of the said emulsion type adhesive liquid is 35 mN / m or less.   The manufacturing method according to any one of claims 9 to 11, wherein the patch for skin patch is the patch for skin patch according to any one of claims 1 to 6.

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