JP2018123107A - Solid composition for oral care - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a solid composition for oral care that can improve an intraoral sanitary state by foaming in the oral cavity.SOLUTION: A solid composition for oral care contains, based on the total amount of the composition, carbonates 20-80 mass% and acidic substance 20-80 mass%, but contains no basic amino acids. The reaction between the carbonates and the acidic substance causes foaming in an oral cavity.SELECTED DRAWING: None

Description

  The present invention relates to a solid composition for oral care. More specifically, the present invention relates to a solid composition for oral care that can improve the hygiene of the oral cavity by causing foaming in the oral cavity.

  Saliva maintains a moist state in the oral cavity and plays an important role in maintaining oral health. It is known that dry mice (oral dry mouth) in which the amount of saliva secretion decreases causes the development of oral diseases such as caries and the development of bad breath. In addition, food residues and tongue coating remaining on the tongue and between teeth are known to cause bad breath. Therefore, improvement of oral hygiene is important from the viewpoint of beauty and health.

  Conventionally, oral compositions that improve the hygiene of the oral cavity by foaming in the oral cavity are known. For example, Patent Document 1 describes an oral composition containing a sodium bicarbonate (sodium bicarbonate) and an acidic component in a non-aqueous oral composition base (for example, liquid paraffin, polyethylene glycol, etc.). . Patent Document 2 describes an effervescent composition containing a basic amino acid, an acid source (such as citric acid) and a soluble carbonate salt. Patent Document 3 describes an oral cleaning composition containing baking soda, an acid, an emulsifier, and a base material. Patent Document 4 describes a solid preparation for oral hygiene containing foaming components (carbonates and organic acids).

JP 2002-302429 A Special table 2011-511797 gazette JP 2014-196278 A International Publication WO99 / 27901

  An object of the present invention is to provide a solid composition for oral care that can improve the hygiene of the oral cavity by causing foaming in the oral cavity.

  The present invention contains 20-80% by mass of carbonates and 20-80% by mass of acidic substances in the total amount of the composition, does not contain basic amino acids, and reacts with the carbonates and acidic substances in the oral cavity. The gist of the composition is a solid composition for oral care that causes foaming.

In Example 1, it is a figure which shows the surface of the tongue before using the composition 1. FIG. In Example 1, it is a figure which shows the surface of the tongue after using the composition 1. FIG.

  Hereinafter, the solid composition for oral care of the present invention (hereinafter simply referred to as “composition”) will be described in more detail.

  The carbonate is not particularly limited as long as it can be used for oral cavity and can generate foam (mainly carbon dioxide gas) by reacting with the acidic substance in the oral cavity. The carbonates mean at least one of carbonates and bicarbonates. As the carbonates, one or more carbonates, one or more bicarbonates, or a combination of one or more carbonates and one or more bicarbonates can be used.

  Specific examples of the carbonates include alkali metal carbonates and bicarbonates (eg, sodium carbonate, sodium bicarbonate, potassium carbonate, potassium bicarbonate), and ammonium carbonate. Further, a double salt such as sodium sesquicarbonate may be used as the carbonate. Only 1 type may be used for the said carbonates, and 2 or more types of mixtures may be used for it. The carbonates are preferably alkali metal hydrogen carbonates, and more preferably sodium hydrogen carbonate.

  The content of the carbonate is 20 to 80% by mass, preferably 25 to 75% by mass, preferably 30 to 70% by mass, more preferably 35 to 65% by mass, and more preferably 40 to 60% by mass in the total amount of the composition. %. It is preferable for the content of the carbonates to be within the above range because foaming sufficient for oral care can be produced. The lower limit of the content of the carbonates is 20% by mass, 22% by mass, 25% by mass, 28% by mass, 30% by mass, 32% by mass, 35% by mass, 37% by mass or 40% in the total amount of the composition. It can be made into the mass%. Further, the upper limit of the content of the carbonates is 80% by mass, 77% by mass, 75% by mass, 72% by mass, 70% by mass, 67% by mass, 65% by mass, 62% by mass, Or it can be 60 mass%. The content range of the carbonates can be selected by combining these upper limit value and lower limit value.

  The acidic substance can be used for the oral cavity, and there is no limitation on the type thereof as long as foaming (mainly carbon dioxide gas) can be generated by reacting with the carbonates in the oral cavity. As the acidic substance, an organic acid or an acid salt thereof, an inorganic acid or an acid salt thereof can be used.

  Specific examples of the organic acid include, for example, tartaric acid, malic acid, citric acid, acetic acid, aluminum lactate, calcium lactate, adipic acid, oxalic acid, malonic acid, succinic acid, glutaric acid, glycolic acid, diglycolic acid, nitrilolic acid. Triacetic acid, ethylenediaminetetraacetic acid and ascorbic acid, and their acid salts. Specific examples of the inorganic acid include acidic phosphates. The acidic substance may be used alone or in combination of two or more. The acidic substance is preferably one or more organic acids, and more preferably citric acid, tartaric acid, and malic acid.

  Content of the said acidic substance is 20-80 mass% in a composition whole quantity, Preferably it is 22-75 mass%, Preferably it is 25-70 mass%, More preferably, it is 30-65 mass%, More preferably, it is 30-60 mass. %. When the content of the acidic substance is within the above range, foaming sufficient for oral care can be generated, which is preferable. The lower limit of the content of the acidic substance can be 20% by mass, 22% by mass, 25% by mass, 28% by mass, or 30% by mass in the total amount of the composition. The upper limit of the content of the acidic substance is 80% by mass, 77% by mass, 75% by mass, 72% by mass, 70% by mass, 67% by mass, 65% by mass, 62% by mass, Or it can be 60 mass%. The range of the content of the acidic substance can be selected by combining these upper limit value and lower limit value.

  The combination of the carbonate and the acidic substance is preferably one or more of a hydrogen carbonate and an organic acid or an acid salt thereof, more preferably a carbonate containing an alkali metal hydrogen carbonate and an organic acid or an acid thereof. It is an acidic salt, and more preferably sodium bicarbonate (sodium bicarbonate), tartaric acid, malic acid, and citric acid, or one or more of them.

  The total content of the carbonates and the acidic substance can be appropriately selected within the scope of the present invention. The total content is usually 40 to 99% by mass, preferably 45 to 95% by mass, and more preferably 50 to 95% by mass in the total amount of the composition. The lower limit of the total content is 40% by mass, 45% by mass, 50% by mass, 55% by mass, 60% by mass, 65% by mass, 70% by mass, 75% by mass, and 80% by mass in the total amount of the composition. Or 85% by mass. The upper limit of the total content is 99% by mass, 98% by mass, 97% by mass, 96% by mass, 95% by mass, 94% by mass, 93% by mass, 92% by mass, and 91% by mass in the total amount of the composition. Or 90% by mass. In the present invention, the total range of the contents can be selected by combining these upper limit value and lower limit value.

  The composition does not contain basic amino acids. The basic amino acid is an amino acid having a carboxyl group and an amino group in the molecule, being water-soluble and giving an aqueous solution having a pH of 7 or higher. Specific examples of the basic amino acid include arginine, lysine, citrulline, ornithine, creatine, histidine, diaminobutanoic acid, diaminopropionic acid, salts thereof, and combinations thereof. Note that “not containing basic amino acid” means not only a case where no basic amino acid is contained, but also a base less than an effective amount (the amount by which the basic amino acid causes some function for improving oral hygiene). (For example, 5% by weight or less, 3% by weight or less, 1% by weight or less, 0.5% by weight or less, 0.3% by weight or less, 0.1% by weight or less in the total amount of the composition) 0.05% by mass or less, or 0.01% by mass or less).

  The dosage form of the composition is not particularly limited as long as it is solid. Specific examples of the dosage form include tablets, capsules, powders, and granules. One embodiment of the composition of the present invention is preferably a powder or a granule. These dosage forms can be obtained by known formulation methods.

  In the present composition, the carbonates and the acidic substance may exist in separate forms or may exist in an integrated form. For example, when the present composition is a tablet, it may be a tablet containing the carbonates and the acidic substance in one layer, and a multilayer form in which a layer containing the carbonates and a layer containing the acidic substance exist separately. But you can. Moreover, when this composition is a granule, the said carbonates and the said acidic substance may be granulated independently, and both may be granulated integrally.

  The composition can be freely modified within the scope described in the claims. For example, the present composition may contain other components as long as the effects of the present invention are not inhibited. For example, the composition may contain sweetening or flavoring agents. In addition, when the dosage form of the composition is a granule, sugars (for example, xylitol, mannitol, sucrose ester, and reduced maltose starch syrup) can be added for granulation. Furthermore, this composition adds other oral medicinal ingredients that can improve the hygiene condition in the oral cavity (for example, peanut extract with an effect of preventing bad breath, lactoferrin with antibacterial action, and lactoperoxidase). be able to.

  This composition may be used as a food or a cosmetic. The composition of the present invention may be swallowed as it is after use in the oral cavity, or may be discharged from the mouth. One embodiment of the present invention is a gargle. The mouthwash is foamed in the oral cavity after administration (if necessary, water may be used at the time of administration), and then the residue of the mouthwash is discharged from the mouth, It is a preparation that cleans the mouth. When the residue of the gargle is discharged from the mouth, rinsing with a liquid such as water may be performed as necessary.

  This composition can improve the sanitary condition in the oral cavity by causing foaming in the oral cavity. As one embodiment of the present composition, dirt in the oral cavity can be removed by causing foaming in the oral cavity. The dirt in the oral cavity is, for example, various kinds of dirt existing on the tongue (for example, food residues, food-derived pigments, lipids, proteins, tongue coating), tooth surface dirt, and gums and periodontal pockets. Of dirt. This is because the foam generated in the oral cavity is fine, so it can easily enter into fine spaces such as on the tongue, between the teeth, and in the periodontal pockets. Therefore, it is considered that the dirt in the oral cavity is physically removed or chemically decomposed (this view is an explanation for promoting the understanding of the invention and is not an explanation for defining the present invention). As an embodiment of the present composition, the present composition can be used for oral cleansing.

  Further, as one embodiment of the present composition, by causing foaming in the oral cavity, it is possible to improve blood flow and promote blood circulation in capillaries in the oral cavity including gums. This is thought to be due to the physical irritation applied to the gums by foaming, and in particular, the foam generated in the oral cavity is so fine that physical irritation can be applied over a wide area of the gums (the view is that It is an explanation for facilitating understanding of the invention and is not an explanation for defining the present invention.) As a result, the gums can be tightened, and prevention and improvement of diseases caused by hygienic conditions of the gums such as alveolar pyorrhea and periodontal disease can be achieved. Therefore, as one embodiment of the present composition, the present composition can be used for gum care.

  Further, as one embodiment of the present composition, salivation can be promoted by physical stimulation of the oral cavity, particularly mucous membrane, by foaming (this view facilitates understanding of the invention). And is not an explanation for defining the present invention.) Thereby, the dry mouth state can be improved. Therefore, as one embodiment of the present composition, the present composition can be used for promoting salivary secretion.

Example 1
The blending components and blending amounts in the composition (Composition 1) used in this example are shown in Table 1 below. Of each component listed in Table 1, sodium bicarbonate and auxiliary materials (of the components in Table 1 other than sodium bicarbonate and citric acid) are pulverized with a pulverizer, mixed with water, and then mixed with a granulator. By granulating, sodium bicarbonate granules were obtained. Similarly, granulation was performed using citric acid and auxiliary materials among the components shown in Table 1 to obtain citric acid granules. About the baking soda granule and the citric acid granule, after sieving, respectively, the granular composition 1 was obtained by mixing both granule.

  After having the subject drink commercially available coffee, Composition 1 (1 g) was administered into the subject's mouth along with water. The composition 1 and water were retained in the oral cavity for about 1 minute to cause sufficient foaming in the oral cavity, and then discharged. The degree of removal of dirt on the tongue was evaluated by comparative observation of the state of the tongue before and after the administration of Composition 1. The results are shown in FIG. 1 (state of the tongue surface before using the composition 1) and FIG. 2 (state of the tongue surface after using the composition 1).

  FIG. 1 shows that when the coffee is drunk, the tongue surface is white or brown, and the tongue surface is contaminated with coffee. On the other hand, in FIG. 2, it can be seen that the white and brown are removed from the tongue surface, and the tongue surface is changed to red, which is the original color of the tongue. From these results, it can be seen that the composition 1 is administered into the oral cavity to cause foaming, so that the dirt on the surface of the tongue is removed and the hygiene condition in the oral cavity can be improved.

Claims (3)

  In the total amount of the composition, 20-80% by mass of carbonates and 20-80% by mass of acidic substances, no basic amino acids, and foaming occurs in the oral cavity by the reaction of the carbonates and acidic substances A solid composition for oral care.   The solid composition for oral care according to claim 1, wherein the composition is a mouthwash.   The solid composition for oral care according to claim 1 or 2, wherein the total content of the carbonates and the acidic substance is 40 to 99% by mass in the total amount of the composition.