JP2018111506A - Packaging bag with a spout - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a packaging bag with a spout, highly reliable in inhibiting adsorption and alteration of stored contents such as drugs and biomedical materials.SOLUTION: A packaging bag 31 with a spout consists of a bag body 17 which is made by overlapping two sheets of laminated body 10 with three layers, i.e. base material layer 11, sealant layer 12 and thin layer 13 which contacts a stored content 16, laminated in this order, and a spout 20 which is set between the overlapped sheets of laminated body 10. The sealant layer 12 contains cyclic olefin resins and the thin layer 13 contains compounds of long molecular chain including a phosphorylcholine-group. Of the spout 20, at least a part contacting a stored content 16, contains cyclic olefin resins.SELECTED DRAWING: Figure 1

Description

  The present invention relates to a packaging bag with a spout.

  A packaging bag using a sealant resin such as polyolefin is used as a packaging material for products applied to living bodies such as pharmaceuticals. However, since polyolefin is highly lipophilic and hydrophobic, active ingredients such as pharmaceuticals may be adsorbed on the sealant resin layer, and components such as proteins contained in biomaterials may be altered.

  Patent Document 1 describes a non-adsorbing package formed by bag-making a non-adsorbing packaging material having a non-adsorbing layer made of a phosphorylcholine group-containing polymer.

Japanese Patent Laying-Open No. 2015-47703

  The phosphorylcholine group-containing polymer has high hydrophilicity. For this reason, when making non-adsorptive packaging material in which a non-adsorptive layer made of a phosphorylcholine group-containing polymer is laminated, the adhesiveness of the packaging material is lowered, and there is a problem in reliability such as durability and sealability. There is a fear.

  The present invention has been made in view of the above circumstances, and it is an object of the present invention to provide a packaging bag with a spout having high reliability as a packaging bag in which adsorption and alteration of contents such as pharmaceuticals and biomaterials are suppressed. And

  In order to solve the above-mentioned problem, the present invention comprises a packaging bag composed of a laminate having a base material layer, a sealant layer, and a thin film layer in contact with the contents in this order, and a spout is provided between the laminates. A spouted packaging bag having a bonded configuration, wherein the sealant layer includes a cyclic olefin-based resin, the thin film layer includes a long molecular chain compound including a phosphorylcholine group, Provided is a packaging bag with a spout, wherein at least a portion in contact with the contents contains a cyclic olefin-based resin.

The thin film layer may be laminated up to a junction between the laminate and the spout.
The coating layer containing polyolefin resin may be laminated | stacked on the part exposed to the outer side of the said packaging bag at least among the outer peripheral surfaces of the said spout.
The long-chain compound containing the phosphorylcholine group is a copolymer of the monomer containing the phosphorylcholine group and another monomer, and the proportion of the monomer containing the phosphorylcholine group in the copolymer is 30 to 95. It may be mol%.

The ratio of the copolymer containing the phosphorylcholine group-containing monomer may be adjusted according to the properties of the contents of the packaging bag.
When the content is a drug containing a hydrophilic compound, the proportion of the copolymer containing the phosphorylcholine group in the copolymer may be 70 to 95 mol%.
When the content is a drug containing a hydrophobic compound, the proportion of the copolymer containing the phosphorylcholine group in the copolymer may be 30 to 70 mol%.

  According to the present invention, the packaging bag is composed of a laminate having a thin film layer containing a long molecular chain compound containing a phosphorylcholine group, so that adsorption or alteration can be achieved even if the contents are pharmaceuticals, biomaterials, etc. Can be suppressed. Moreover, by using cyclic olefin-type resin, it is excellent in adhesiveness and can improve the reliability as a packaging bag.

It is sectional drawing which shows typically the packaging bag with a spout of 1st Embodiment. It is sectional drawing which shows typically the packaging bag with a spout of 2nd Embodiment.

Hereinafter, based on a preferred embodiment, the present invention will be described with reference to the drawings.
The cross-sectional view of FIG. 1 schematically shows a packaging bag 31 with a spout according to the first embodiment. The spout-equipped packaging bag 31 includes a packaging bag 17 for storing the contents 16 and a spout 20 for taking out the contents 16 from the packaging bag 17. In the schematic diagram, the specific state, shape, and the like of the contents 16 are not illustrated, but are not particularly limited, and examples thereof include solids, liquids, gases, powders, granules, mixtures, compositions, and dispersions. Can be mentioned.

  The packaging bag 17 is comprised from the laminated body 10 which has the base material layer 11, the sealant layer 12, and the thin film layer 13 which touches the content 16 in this order.

  The base material layer 11 may have a single-layer configuration composed of one layer, or a stacked configuration of two or more layers. Although the layer which comprises the base material layer 11 can be selected suitably, a reinforcement layer, a gas barrier layer, a light shielding layer, a printing layer, metal foil, synthetic paper etc. are mentioned, for example. Examples of a method for laminating each layer constituting the base material layer 11 include a dry laminating method, an extrusion laminating method, a coextrusion method, and the like, and can be appropriately selected depending on the combination of the respective layers. The whole base material layer 11 may be colorless and transparent, and a part or all of the thickness direction or the surface direction may be colored.

Examples of the reinforcing layer include reinforcing resin layers such as biaxially stretched polyethylene terephthalate (O-PET), biaxially stretched nylon (O—Ny), and biaxially stretched polypropylene (OPP).
The gas barrier layer can be composed of, for example, an inorganic material or a gas barrier resin. As an inorganic substance, metal oxide layers, such as a metal vapor deposition layer and an alumina, are mentioned. Examples of the gas barrier resin include ethylene-vinyl alcohol copolymer (EVOH), vinylidene chloride, fluororesin (PCTFE, PTFE, PFA) and the like.

  The sealant layer 12 is made of a cyclic olefin resin. Examples of the cyclic olefin-based resin include a cyclic olefin polymer (COP) and a cyclic olefin copolymer (COC). The resin component constituting the sealant layer 12 may be one or more of cyclic olefin resins, or may be a mixture of a cyclic olefin resin and other resins or elastomers.

  Examples of the cyclic olefin polymer (COP) include a homopolymer of a cyclic olefin, a copolymer of two or more cyclic olefins, or a hydrogenated product thereof. The cyclic olefin polymer is preferably an amorphous polymer, more preferably a cyclic olefin ring-opening polymer obtained by metathesis or the like, or a hydrogenated product thereof. The cyclic olefin polymer has a higher ratio of containing an alicyclic structure than the cyclic olefin copolymer and the like, and is excellent in non-adsorption.

  Examples of the cyclic olefin copolymer (COC) include a copolymer of one or two or more cyclic olefins and one or two or more acyclic olefins, or a hydrogenated product thereof. The cyclic olefin copolymer is preferably an amorphous polymer, more preferably a copolymer of cyclic olefin and ethylene, or a hydrogenated product thereof.

  The cyclic olefin used as a constituent monomer of the cyclic olefin-based resin is an unsaturated hydrocarbon (olefin) having at least one ring structure. Examples thereof include vinylcycloalkanes having 3 to 20 carbon atoms and derivatives thereof, monocycloalkenes having 3 to 20 carbon atoms and derivatives thereof, and cyclic olefins having a norbornene skeleton (norbornene monomers). It is done.

Examples of the norbornene-based monomer include bicyclo [2.2.1] -2-heptene (norbornene) and derivatives thereof. Derivatives include compounds having a substituent such as an alkyl group, compounds having two or more unsaturated bonds such as norbornadiene, compounds having three or more ring structures, of which two ring structures constitute a norbornene skeleton. Can be mentioned. Examples of norbornene-based monomers having three or more ring structures include tricyclo [5.2.1.0 ^2,6 ] decene (dihydrodicyclopentadiene), norbornene or dihydrodicyclopentadiene, and one or more molecules of cyclopentadiene. Compounds added by Diels-Alder reaction (for example, tetracyclododecene, pentacyclopentadecene, hexacycloheptadecene, etc.), hydrogenated products thereof, isomers having different double bond positions, alkyl substituents, etc. .

  Examples of the acyclic olefin used as a constituent monomer of the cyclic olefin copolymer (COC) include α-olefins such as ethylene, propylene, 1-butene, 1-pentene, 1-hexene, 1-heptene, and 1-octene, Alkenes such as 3-decene and 3-dodecene are exemplified.

  The thin film layer 13 is composed of a long molecular chain compound containing a phosphorylcholine group. The phosphorylcholine group is a (trimethylammonio) ethoxyphosphoryl group, that is, a group represented by the following formula.

_{^{-O-P (O) (O}} -) -OCH 2 CH 2 N (CH 3) 3 +

  The long-chain compound containing a phosphorylcholine group is not limited to phospholipids such as phosphatidylcholine (lecithin) and sphingomyelin derived from nature, but includes a polymer containing a phosphorylcholine group in the side chain. A copolymer of at least one monomer containing a phosphorylcholine group and one or more other monomers is preferred. In particular, a (meth) acrylic copolymer containing a phosphorylcholine group is preferred.

  Examples of the monomer containing a phosphorylcholine group include one or more monomers represented by the following formula.

_{^{CH 2 = C (R 1)}} COO-R 2 -O-P (O) (O -) -OCH 2 CH 2 N (CH 3) 3 +

Here, as R ^1, for example, it includes substituents such as a hydrogen atom or a methyl group. Examples of R ² include divalent organic groups such as an ethylene group, a propylene group, a trimethylene group, a butylene group, and an alkylene group. A particularly preferred monomer is 2-methacryloyloxyethyl phosphorylcholine, ie 2- (methacryloyloxy) ethyl, wherein R ¹ is a methyl group (—CH ₃ ) and R ² is an ethylene group (—CH ₂ CH ₂ —). 2- (Trimethylammonio) ethyl phosphate.

  (Trialkylammonio) ethoxy such as (triethylammonio) ethoxyphosphoryl group, (tripropylammonio) ethoxyphosphoryl group instead of (trimethylammonio) ethoxyphosphoryl group as part of the monomer containing phosphorylcholine group It is also possible to use a monomer containing a phosphoryl group in combination.

  As at least a part of other monomers, hydrophobic monomers such as acyclic alkyl (meth) acrylate, cyclic alkyl (meth) acrylate, aromatic (meth) acrylate, styrene monomer, vinyl ether monomer, vinyl ester monomer, and the like Can be mentioned.

Examples of the acyclic alkyl (meth) acrylate include methyl (meth) acrylate, ethyl (meth) acrylate, butyl (meth) acrylate, 2-ethylhexyl (meth) acrylate, isooctyl (meth) acrylate, and stearyl (meth) acrylate. It is done.
Examples of the cyclic alkyl (meth) acrylate include cyclopentyl (meth) acrylate and cyclohexyl (meth) acrylate.

Examples of the aromatic (meth) acrylate include benzyl (meth) acrylate, phenylethyl (meth) acrylate, phenoxyethyl (meth) acrylate, and the like.
Examples of the styrene monomer include styrene, α-methylstyrene, chloromethylstyrene, and the like.

Examples of vinyl ether monomers include alkyl vinyl ethers such as methyl vinyl ether and ethyl vinyl ether.
Examples of vinyl ester monomers include fatty acid vinyl esters such as vinyl acetate and vinyl propionate.

  As a part of other monomers, a (meth) acrylate having a hydroxyl group, a (meth) acrylate having an amino group, a (meth) acrylic monomer having a carboxyl group, a (meth) acrylic monomer having an amide group, an ether group It is also possible to use one or two or more of (meth) acrylic monomers or the like having them.

Examples of the (meth) acrylate having a hydroxyl group include hydroxyalkyl (meth) acrylates such as 2-hydroxyethyl (meth) acrylate and 4-hydroxybutyl (meth) acrylate.
Examples of the (meth) acrylate having an amino group include aminoethyl (meth) acrylate and dimethylaminoethyl (meth) acrylate.

Examples of the (meth) acrylic monomer having a carboxyl group include acrylic acid, methacrylic acid, and carboxyethyl (meth) acrylate.
Examples of the (meth) acrylic monomer having an amide group include (meth) acrylamide, dimethyl (meth) acrylamide, and diethyl (meth) acrylamide.
Examples of the (meth) acrylic monomer having an ether group include methoxyethyl (meth) acrylate, ethoxy (meth) acrylate, polyethylene glycol (meth) acrylate, polypropylene glycol (meth) acrylate, and glycidyl (meth) acrylate.

  By including the phosphorylcholine group, the thin film layer 13 can impart hydrophilicity and biocompatibility to the surface of the laminate 10. For example, even when the contents 16 contain proteins such as enzymes, cells, and biological tissues, protein aggregation can be suppressed. In the thin film layer 13, a long molecular chain compound containing a phosphorylcholine group may constitute a monomolecular film.

  In the copolymer containing a phosphorylcholine group, the proportion of the monomer containing the phosphorylcholine group is preferably 30 to 95 mol%. Here, the proportion of the phosphorylcholine group-containing monomer can be determined by [m / (m + n)] × 100% when the molar ratio of the phosphorylcholine group-containing monomer to the other monomer is m: n. .

The proportion of the phosphorylcholine group-containing monomer can be further selected from 30 to 70 mol%, 55 to 60 mol%, 70 to 95 mol%, 80 to 90 mol%, and the like.
In addition, the balance between hydrophilicity and hydrophobicity can be improved by using a hydrophobic monomer and a hydrophilic monomer in combination with other monomers.
When packaging drugs such as pharmaceuticals with the package of the present invention, it is preferable to appropriately change the proportion of the monomer containing phosphorylcholine groups in the copolymer containing phosphorylcholine groups depending on the properties of the contents. For example, in the case of a drug containing a hydrophilic compound such as immunoglobulin, it is preferably 70 to 95 mol%, more preferably 80 to 90 mol%. In the case of a drug containing a hydrophobic compound such as bovine serum albumin, it is preferably 30 to 70 mol%, more preferably 55 to 65 mol%. The drug may be a solution such as an injection solution. As a method of determining the ratio of the monomer containing a phosphorylcholine group, there is a method of testing the aggregating property of a drug against a packaging bag and selecting a packaging bag that has no problem such as aggregation of compounds such as proteins.

  Examples of the method for forming the thin film layer 13 on the laminate 10 include a method of applying a long molecular chain compound containing a phosphorylcholine group to the surface of the sealant layer 12. The base material layer 11 and the sealant layer 12 are preferably laminated before the thin film layer 13 on the sealant layer 12 is formed.

  Examples of a method for laminating the base material layer 11 and the sealant layer 12 include a dry laminating method and an extrusion laminating method. When laminating the base material layer 11 and the sealant layer 12, an adhesive can be interposed as necessary. Examples of the adhesive include an anchoring agent such as polyurethane, polyether, alkyl titanate (organic titanium compound), or an adhesive resin such as acid-modified polyolefin.

The composition used for coating the thin film layer 13 may contain a solvent, an additive and the like together with a long molecular chain compound containing a phosphorylcholine group. Examples of the solvent include a mixed solvent of water and ethanol. In order to reduce the hydrophobicity of the surface of the sealant layer 12, one or more gases such as oxygen (O ₂ ), ozone (O ₃ ), and nitrogen (N ₂ ) are applied to the surface of the sealant layer 12 before coating. It is preferable to perform a corona treatment or a plasma treatment in an atmosphere containing. Thereby, an oxygen functional group or a nitrogen functional group is introduced into the surface of the sealant layer 12, and hydrophilicity can be imparted.

  The packaging bag 17 composed of the laminate 10 described above includes a first joint end 14 to which the spout 20 is joined between the laminate 10, and a second joint end 15 to which the laminates 10 are joined. Can be included. The entire periphery of the packaging bag 17 may be constituted by the first joint end 14 or the second joint end 15, and a part of the periphery is a folded portion in which the laminated body 10 is mountain-folded into a V-shaped cross section. May be configured. Before the content 16 is filled, a part of the periphery of the packaging bag 17 may be opened with a filling port for filling the packaging bag 17 with the content 16.

In the present embodiment, the thin film layer 13 is stacked up to the joint portion 25 between the stacked body 10 and the spout 20. For this reason, the laminated configuration of the first joint end 14 is in the order of “base material layer 11 / sealant layer 12 / thin film layer 13 / outlet 20 / thin film layer 13 / sealant layer 12 / base material layer 11”. Yes. The first joint end portion 14 and the second joint end portion 15 can be configured by fusing resin contained in the sealant layer 12 of the laminate 10 or the main body portion 21 of the spout 20.
Since the thin film layer 13 is formed on substantially the entire inner surface of the laminate 10, the sealant layer 12 is not easily exposed on the inner surface of the laminate 10 in contact with the contents 16, which is preferable.

  As for spout 20 joined between layered products 10 which constitute packaging bag 17, it is preferred that at least a portion which touches contents 16 contains cyclic olefin system resin. Examples of the cyclic olefin-based resin include cyclic olefin-based resins such as a cyclic olefin polymer (COP) and a cyclic olefin copolymer (COC) similarly to the material of the sealant layer 12. However, the cyclic olefin resin used for the spout 20 is not limited to the same type as the cyclic olefin resin used for the sealant layer 12, and may be a different type of cyclic olefin resin.

  For example, the same kind or different kinds of COPs may be used for both the spout 20 and the sealant layer 12. Further, the same kind or different kinds of COC may be used for both the spout 20 and the sealant layer 12. Further, COP may be used for the spout 20 and COC may be used for the sealant layer 12. Further, COC may be used for the spout 20 and COP may be used for the sealant layer 12.

  The resin component constituting the main body portion 21 of the spout 20 may be one or more of cyclic olefin resins, or may be a mixture of a cyclic olefin resin and another resin or an elastomer. Of the spout 20, at least the inner surface of the flow path 23 in contact with the contents 16 is composed of a main body 21 containing a cyclic olefin resin.

  Of the outer peripheral surface of the spout 20, a coating layer 22 containing a polyolefin resin may be laminated on at least the outer peripheral surface of the outer exposed portion 26 exposed outside the packaging bag 17. In this embodiment, the inner side exposed part 24 exposed so that it may contact the contents 16 inside the packaging bag 17 among the spouts 20 is comprised from the main-body part 21 containing cyclic olefin resin. Further, the coating layer 22 is laminated on the outer peripheral surface of at least a part of the joint portion 25 and the outer exposed portion 26 in the spout 20. When the coating layer 22 containing a polyolefin resin is laminated on the outer peripheral surface of the outer exposed portion 26, the joining at the joining portion 25 between the laminate 10 and the spout 20 can be ensured. Further, since the spout is covered with the polyolefin resin, the spout is hardly broken by an external impact, and the strength is increased.

  The polyolefin resin constituting the coating layer 22 may be a homopolymer of one olefin or a copolymer (copolymer) of two or more olefins. Examples of the olefin include acyclic olefins such as ethylene, propylene, 1-butene, 1-hexene, 1-octene, and α-olefin. Specific examples of the polyolefin include polyethylene, polypropylene, and ethylene-α-olefin copolymer. These polyolefins may be copolymers containing a small amount of non-olefinic vinyl monomers such as vinyl acetate, vinyl chloride and vinyl alcohol. The origin of the olefin may be petroleum-derived olefin, plant-derived olefin, or a combination of both.

  On the spout 20 side of the joint portion 25, the main body portion 21 containing a cyclic olefin resin may be joined to the laminate 10, and the coating layer 22 containing a polyolefin resin may be joined to the laminate 10. . In the junction part 25, both the location where the main-body part 21 was joined with the laminated body 10, and the location where the coating layer 22 was joined with the laminated body 10 may be contained.

  The form of the packaging bag 17 can be applied without particular limitation, such as a three-sided bag, a four-sided bag, a jointed bag, a gusset bag, a self-supporting bag, a pouch, a large bag such as an inner bag for a bag-in-box or a drum can interior bag. . In addition to the spout, the packaging bag of the present embodiment can be provided with accessories such as an inlet, a cock, a label, an opening knob, and a handle. When the accessory is a resin molded product, the same configuration as the above-described spout may be used.

  Examples of the contents 16 that can be suitably stored in the packaging bag 17 include pharmaceuticals, cells, tissues, organs, biomaterials, blood, body fluids, enzymes, antibodies, beauty products, nutrients, health agents, cosmetics, foods, and the like. . When the content 16 is stored in the packaging bag 17, it may be filled with an inert gas or liquid such as nitrogen.

  As mentioned above, although this invention has been demonstrated based on suitable embodiment, this invention is not limited to the above-mentioned embodiment, A various change is possible in the range which does not deviate from the summary of this invention.

The packaging bag 31 with a spout shown in FIG. 1 is in a state where there is no aggregation of the contents because the sealant layer 12 is not in principle in contact with the contents at the joint 25 between the laminate 10 and the spout 20. Easy to keep.
In the spout-equipped packaging bag 32 shown in FIG. 2, the thin film layer 13 is omitted at the joint portion 25 between the laminate 10 and the spout 20. For this reason, the laminated structure of the first joining end portion 14 is in the order of “base material layer 11 / sealant layer 12 / spout 20 / sealant layer 12 / base material layer 11”. In this case, since the sealant layer 12 and the spout 20 are directly joined, the joining can be made more reliable. On the inner surface of the laminate 10 in contact with the contents 16, the gap between the thin film layers 13 where the sealant layer 12 is exposed is made as narrow as possible in order to reduce the area where the sealant layer 12 contacts the contents and prevent the contents from agglomerating. It is preferable.

  Hereinafter, the present invention will be specifically described with reference to examples. In addition, this invention is not limited only to an Example.

Example 1
After laminating a base material layer 11 made of linear low density polyethylene (LLDPE) and a sealant layer 12 made of a cyclic olefin polymer (COP), 2-methacryloyloxyethyl phosphorylcholine (MPC) is formed on the entire surface of the sealant layer 12. The thin film layer 13 was formed by coating a copolymer containing 90 mol% of the laminate, and the laminate 10 was produced.
Moreover, the substantially cylindrical spout 20 in which the inner side was composed of a cyclic olefin polymer (COP) and the outer part was composed of polyethylene (PE) was molded by a two-color molding method.
The spout 20 is sandwiched between the two laminates 10, and the first joint end 14 between the laminate 10 and the spout 20 and the second joint end 15 between the laminates 10 are joined. Thus, a packaging bag with a spout of Example 1 was produced.

(Example 2)
When the thin film layer 13 is formed on the laminated body 10, the thin film layer 13 is not applied to the regions to be the first joint end 14 and the second joint end 15, and the sealant layer 12 is formed on the inner surface of the laminate 10. A packaging bag with a spout of Example 2 was produced in the same manner as Example 1 except that it was exposed.

(Example 3)
Example 3 is the same as Example 1 except that a copolymer containing 2-methacryloyloxyethyl phosphorylcholine (MPC) at a ratio of 60 mol% is applied as a copolymer constituting the thin film layer 13. A packaging bag with a spout was produced.

(Comparative Example 1)
A base material layer made of linear low density polyethylene (LLDPE) and a sealant layer made of polyethylene (PE) were laminated to prepare a laminate for constituting a packaging bag.
A pouch with a spout of Comparative Example 1 is formed by sandwiching a spout made of polyethylene (PE) between two laminates and joining the laminate and spout and between the laminates. Was made.

(Comparative Example 2)
A packaging bag with a spout of Comparative Example 2 was produced in the same manner as in Example 2 except that the sealant layer was made of polyethylene (PE) and a spout made of polyethylene (PE) was used.

(Evaluation of cohesiveness)
As contents of the packaging bags with spouts of Examples 1 to 3 and Comparative Examples 1 to 2, preparations (drug substance) containing immunoglobulins or bovine serum albumin were filled. The state of the contents is checked with an optical microscope to evaluate the cohesiveness. When there is no aggregation, “◎”, when there is almost no aggregation, “○”, when there is little aggregation, “△”, there is much aggregation. When it occurred, it was set as “x”.

  The results are summarized in Table 1. “MPC ratio” in Table 1 is a ratio (mol%) occupied by MPC in the copolymer constituting the thin film layer.

  In the thin film layer for immunoglobulin, the proportion of MPC in the copolymer is 90 mol% according to Example 1, but is preferably 70 to 95 mol%, and preferably 80 to 90 mol%. Is more preferable.

  In the thin film layer for bovine serum albumin, the proportion of MPC in the copolymer is 60 mol% according to Example 3, but is preferably 30 to 70 mol%, and is preferably 55 to 65 mol%. It is more preferable.

DESCRIPTION OF SYMBOLS 10 ... Laminated body, 11 ... Base material layer, 12 ... Sealant layer, 13 ... Thin film layer, 14 ... 1st joining edge part, 15 ... 2nd joining edge part, 16 ... Contents, 17 ... Packaging bag, 20 ... Note Outlet, 21 ... body part, 22 ... coating layer, 23 ... flow path, 24 ... inner exposed part, 25 ... joined part, 26 ... outer exposed part, 31, 32 ... packaging bag with spout.

Claims (6)

A packaging bag comprising a base material layer, a sealant layer, and a thin film layer in contact with the contents in this order, a packaging bag is configured, and a spout is joined between the laminated bodies. Because
The sealant layer includes a cyclic olefin resin,
The thin film layer includes a long molecular chain compound containing a phosphorylcholine group,
Of the spout, at least a portion in contact with the content contains a cyclic olefin-based resin.   The packaging bag with a spout according to claim 1, wherein the thin film layer is stacked up to a joint portion between the laminated body and the spout.   The spout according to claim 1 or 2, wherein a coating layer containing a polyolefin resin is laminated on at least a portion of the outer peripheral surface of the spout exposed on the outside of the packaging bag. Packaging bag.   The long-chain compound containing the phosphorylcholine group is a copolymer of the monomer containing the phosphorylcholine group and another monomer, and the proportion of the monomer containing the phosphorylcholine group in the copolymer is 30 to 95. It is mol%, The packaging bag with a spout of any one of Claims 1-3 characterized by the above-mentioned.   The spout according to claim 4, wherein the content is a drug containing a hydrophilic compound, and the proportion of the copolymer containing the phosphorylcholine group in the copolymer is 70 to 95 mol%. Packing bag with.   The spout according to claim 4, wherein the content is a drug containing a hydrophobic compound, and the proportion of the copolymer containing the phosphorylcholine group in the copolymer is 30 to 70 mol%. Packing bag with.

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