JP2018105689A - Living body monitoring device and method for analyzing urine - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a living body monitoring device and a method for analyzing urine which can easily determine a health management state about diabetes.SOLUTION: A living body monitoring device 100 includes: a first detection element 101 for detecting water from a detection target; a second detection element 102 for detecting ammonia from the detection target; a third detection element 103 for detecting a ketone body from the detection target; and a determination unit 122 for determining whether the detection target is a smell of urine including a ketone body, on the basis of the results of detections by the first, second, and third detection elements.SELECTED DRAWING: Figure 2

Description

  The present invention relates to a biological monitor device and a urine analysis method.

  Health management devices that can analyze urine that can be mounted on a Western-style toilet installed in a toilet and support an individual's health check have been proposed (see, for example, Patent Document 1, Patent Document 2, and Patent Document 3). .) This health management device is provided with urine collection means and is configured to analyze the collected urine.

JP-A-7-209289 JP-A-10-267925 JP 2000-310631 A

  In the above-described health care apparatus, it is necessary to provide a urine collecting means in order to analyze urine itself, and a large-scale configuration such as providing a washing mechanism for washing the urine collecting means is necessary.

  In view of the circumstances as described above, an object of the present invention is to provide a living body monitor device and a urine analysis method capable of easily determining a health management state related to diabetes.

In order to achieve the above object, a living body monitor apparatus according to an aspect of the present invention includes a first detection element, a second detection element, a third detection element, and a determination unit.
The first detection element detects moisture from a detection target.
The second detection element detects ammonia from the detection target.
The third detection element detects a ketone body from the detection target. The determination unit determines whether the detection target is a ketone body based on the detection results of the first, second, and third detection elements. It is determined whether the urine contains urine.

  According to such a configuration of the present invention, it is possible to determine whether or not the detection target is urine containing ketone bodies, and whether early detection of diabetes, diabetes status and blood glucose control can be appropriately managed. It is possible to easily manage physical condition such as.

  That is, the first and second detection elements can determine whether the detection target is urinated urine.

  When moisture is not detected by the first detection element and ammonia is detected by the second detection element, for example, it can be determined that the detection target is urine adhering to the toilet. On the other hand, when moisture is detected by the first detection element and ammonia is detected by the second detection element, it can be determined that the detection target is a volatile component of urinated urine.

  Further, when moisture is detected by the first detection element and ammonia is not detected by the second detection element, it can be determined that the detection target is a gas molecule of moisture other than urine. On the other hand, when moisture is detected by the first detection element and ammonia is detected by the second detection element, it is possible to determine that the detection target is a gas molecule of the urinated liquid urine.

  In this way, it is possible to determine whether or not the detection target is urinated urine by the first and second detection elements. As a result, it is possible to reduce the occurrence of false detections that erroneously detect those not derived from urinated urine, and perform highly accurate detection.

Then, by detecting whether or not a ketone body is contained in the urinated urine, early detection of diabetes and physical condition management can be easily performed.
Here, acetone, acetoacetic acid, and hydroxybutyric acid are produced when fat is decomposed and used as an energy source, and are collectively called ketone bodies. Even if there is enough carbohydrate due to diabetes and other reasons such as lack of insulin, if sugar is not properly used as an energy source and fat is used as an energy source, ketone bodies are produced and excreted in urine Is done. Therefore, by detecting urine containing a ketone body, it is assumed that the urine is human urine with the possibility of diabetes, leading to early detection of diabetes. In addition, even if diabetic, if the blood sugar can be controlled well, the ketone body does not appear in the urine more than normal. Therefore, in humans who are already known to be diabetic, it is possible to determine whether or not blood glucose control can be properly managed based on the presence or absence of detection of ketone bodies in urine, which can be used for physical condition management. .

The determination unit may determine whether moisture is included in the detection target based on a detection result of the first detection element.
This makes it possible to determine whether the detection target is urine and moisture other than urine.

If the determination unit determines that the detection target contains moisture based on the detection result of the first detection element, does the detection target include ammonia based on the detection result of the second detection element? It may be determined whether or not.
This makes it possible to determine whether the detection target is urine being urinated or water other than urine.

When the determination unit determines that ammonia is included in the detection target based on the detection result of the second detection element, the detection target includes a ketone body based on the detection result of the third detection element. It may be determined whether or not.
This makes it possible to determine whether the detection target is urine containing a ketone body or urine not containing a ketone body.

  You may further comprise the provision part which provides an analysis result to the said detection object based on the determination result by the said determination part.

At least one of the first detection element, the second detection element, and the third detection element may include a vibrator and an adsorption film provided on the vibrator.
Thus, a QCM (Quartz Crystal Microbalance) sensor element may be used as the detection element.

The first detection element may include a first vibrator and a first adsorption film that adsorbs the gas molecules of the water made of polyvinyl alcohol provided on the first vibrator.
Thus, a QCM sensor element can be used as the first detection element, and moisture can be detected using the first adsorption film made of polyvinyl alcohol.

The second detection element has a second vibrator and a second vibrator that adsorbs the ammonia gas molecules made of an organic material having a hydroxyl group or a phosphate group as a sensitive group provided on the second vibrator. You may have the adsorption film.
Thus, a QCM sensor element can be used as the second detection element, and ammonia can be detected using the second adsorption film made of an organic material having a hydroxyl group or a phosphate group as a functional group. As an organic material having a hydroxyl group or a phosphate group as a functional group, for example, ditetradecyl phosphate can be used.

The third detection element is configured to adsorb gas molecules of the ketone body formed using a third vibrator, a vinylidene fluoride resin provided on the third vibrator and trifluoroethylene. You may have 3 adsorption films.
Thus, a QCM sensor element can be used as the third detection element, and acetone, which is a ketone body, is detected by using the third adsorption film formed using vinylidene fluoride resin and trifluoroethylene. be able to.

  In order to achieve the above object, a method for analyzing urine according to one aspect of the present invention detects a ketone body, ammonia and moisture from a detection target, and the detection target is urine containing a ketone body based on the detection result. Analyze whether there is.

If it is analyzed that the detection target is a urine gas molecule containing a ketone body, the detection target may be analyzed as urine having a high possibility of containing urine sugar.
Thus, by detecting a ketone body from urine, it can be analyzed that the detection target is a human urine gas molecule having a high possibility of diabetes, and that urine is likely to contain urine sugar.

  As described above, according to the present invention, it is possible to obtain a living body monitor device and a urine analysis method that can easily determine whether a detection target is urine containing a ketone body.

It is a figure showing composition of a living body monitor system using a living body monitor device concerning an embodiment of the present invention. It is a figure which shows the structure of the biological monitor apparatus shown in FIG. It is a flowchart which shows the detection method of the biological monitor apparatus shown in FIG. It is a figure which shows the adsorption | suction characteristic of each detection element provided in the biological monitor apparatus shown in FIG.

Hereinafter, embodiments of the present invention will be described with reference to the drawings. FIG. 1 shows a configuration of a biological monitor system using a biological monitor device. FIG. 2 shows the configuration of the biological monitor device. The biological monitor device 100 is configured to be attachable to the back of a toilet seat of a Western-style toilet, for example.
The biological monitor device 100 detects moisture, ammonia, and a ketone body from the detection target, and determines whether the detection target is urine containing the ketone body based on these detection results. The analysis result generated based on the determination result can be confirmed by the user on a display device such as a portable device described later. The analysis result is configured to be associated with the detection date and time so that it can be stored in time series, and the user can manage his / her physical condition by checking the time series analysis result on the display device.

  The biological monitor system includes a biological monitor device 100 and a portable device 200 as a display device having a display unit 201 for a result detected by the biological monitor device 100. The portable device 200 and the biological monitor device 100 can wirelessly transmit signals using a communication module.

[Configuration of biological monitoring device]
The biological monitor device 100 includes a substrate (not shown), a first QCM sensor element (hereinafter referred to as a first QCM) 101 as a first detection element, and a second as a second detection element. A QCM sensor element (hereinafter referred to as a second QCM) 102, a third QCM sensor element (hereinafter referred to as a third QCM) 103 as a third detection element, a first frequency counter circuit 111, The second frequency counter circuit 112, the third frequency counter circuit 113, the information processing unit 120, the temperature / humidity sensor 130, the power supply circuit 140, the communication module 150, the lithium ion polymer secondary battery 160, A charging circuit 170, a charging dedicated USB terminal 180, and a power switch (power SW) 190 are provided.

  Each of the three QCMs 101 to 103 has a configuration including a crystal resonator as a resonator and an adsorption film that adsorbs a specific gas provided on the crystal resonator. The basic structure is the same, only different. Since the resonance frequency of the crystal unit decreases in proportion to the weight of the gas adsorbed to the adsorption film, the amount of change in the resonance frequency is measured for each crystal unit, and based on this measurement result, moisture, ammonia It is possible to detect whether or not a ketone body is contained.

  In the present embodiment, a crystal resonator having a resonance frequency of 9 MHz is used as the detection element, but the present invention is not limited to this. For example, ceramic resonators, surface acoustic wave elements, cantilevers, diaphragms, etc. can be used in addition to quartz resonators, and physical changes such as weight increase and expansion stress increase due to gas adsorption of the adsorption film are detected and converted to electrical signals. Applicable if possible.

  The first QCM 101 (second QCM 102, third QCM 103) includes a first crystal resonator 13 (second crystal resonator 23, third crystal resonator 33) and electrodes 11 (21, 31). The first adsorption film 12 (second adsorption film 22, third adsorption film 32), lead land 16A (26A, 36A), lead land 16B (26B, 36B), and lead 14A (24A, 34A), leads 14B (24B, 34B), pin terminals 19A (29A, 39A), and pin terminals 19B (29B, 39B). The quartz oscillator 13 (23, 33) is an AT-cut quartz plate.

  The electrodes 11 (21, 31) are formed on both surfaces of the crystal resonator 13 (23, 33), respectively, and the adsorption film 12 (22, 32) is formed on one surface of the crystal resonator 13 (23, 33). Formed on the electrode 11 (21, 31). The lead land 16A (26A, 36A) is integrally formed with the electrode 11 (21, 31) formed on one surface, and the lead land 16B (26B, 36B) is formed on the other surface. , 31).

The lead 14A (24A, 34A) and the lead 14B (24B, 34B) are made of a metal spring material and are arranged in parallel to each other.
One end of the lead 14A (24A, 34A) is electrically connected to the electrode 11 (21, 31) formed on one surface via the lead land 16A (26A, 36A), and the other end is connected to the pin terminal 19A ( 29A, 39A). One end of the lead 14B (24B, 34B) is electrically connected to the electrode 11 (21, 31) formed on the other surface via the lead land 16B (26B, 36B), and the other end is pin terminal 19B (29B). , 39B).

  The pin terminal 19A (29A, 39A) and the pin terminal 19B (29B, 39B) are supported by the terminal block 18 (28, 38) provided on the substrate, and the crystal unit is supported by the terminal block 18 (28, 38). 13 (23, 33) is supported in a freely oscillating manner.

  The pin terminals 19A (29A, 39A) and 19B (29B, 39B) of the QCM 101 (102, 103) are connected to an oscillation circuit (not shown), and a drive voltage is applied to the QCM 101 (102, 103). When a drive voltage is applied to the QCM 101 (102, 103), the crystal resonator 13 (23, 33) vibrates at a specific resonance frequency (9 MHz in this example).

  The mass of the adsorption film 12 (22, 32) is changed by adsorbing the gas, and the oscillation frequency of the crystal resonator 13 (23, 33) is lowered according to the amount of adsorption. The first QCM 101, the second QCM 102, and the third QCM 103 are connected to the first frequency counter circuit 111, the second frequency counter circuit 112, and the third frequency counter circuit, respectively. The first frequency counter circuit 111 (second frequency counter circuit 112, third frequency counter circuit 113) detects the resonance frequency of the first QCM 101 (second QCM 102, third QCM 103). From each of the frequency counter circuits 111 to 113, an electrical signal having the detected resonance frequency is output to the information processing unit 120.

  The first QCM 101 detects moisture, the second QCM 102 detects ammonia, and the third QCM 103 detects a ketone body. The adsorption films 12, 22, and 32 formed on the respective QCMs 101 to 103 are made of different materials and different in adsorption characteristics. Details of the adsorption film will be described later.

The temperature / humidity sensor 130 detects the temperature and humidity of the atmosphere in which the biological monitor device 100 is placed. Depending on the type of the adsorption film, the resonance frequency detected by the change in the temperature or humidity of the atmosphere varies greatly.
In the present embodiment, based on the temperature detected by the temperature / humidity sensor 130, the resonance frequency detected by each of the QCMs 101 to 103 is corrected so as to cancel the change in the resonance frequency due to temperature. Resonance frequency change data according to temperature is stored in advance in the storage unit 124 of the information processing unit 120 described later for each adsorption film.

  Further, based on the humidity detected by the temperature / humidity sensor 130, the resonance frequency detected by each of the QCMs 101 to 103 is corrected so as to cancel the change in the resonance frequency due to humidity. Resonance frequency change data corresponding to humidity is stored in advance in the storage unit 124 of the information processing unit 120 described later for each adsorption film.

  In the first QCM 101, the resonance frequency is corrected using humidity detected when urine or water other than urine is not put into the toilet. The first adsorption film 12 of the first QCM 101 is a detection element having a characteristic of adsorbing moisture, adsorbs moisture in the air other than urine, and the resonance frequency changes depending on humidity in the air. Therefore, even if the toilet is not used and urination is not performed, there is a possibility that moisture is detected by the humidity in the air. Therefore, in this embodiment, the resonance frequency detected by the first QCM is corrected so as to cancel the change in resonance frequency due to humidity detected when urine or water other than urine is not put into the toilet. Thus, it is possible to determine whether or not urine or moisture other than urine has been thrown into the toilet without being affected by the humidity in the air. Note that whether or not urine or water other than urine has been put into the toilet can be determined by monitoring changes with time in the humidity change detected from the temperature / humidity sensor 130. When the humidity detected by the temperature / humidity sensor 130 changes abruptly, it is determined that urine or moisture other than urine has been put into the toilet, and is based on the humidity before the sudden humidity change occurs. Thus, the change of the resonance frequency can be corrected.

  In the second QCM 102 and the third QCM 103, the resonance frequency is corrected using the humidity detected when urine or water other than urine is put into the toilet.

  As the temperature / humidity sensor 130, for example, a digital temperature / humidity sensor (model number: SHT21) manufactured by Sensirion Co., Ltd. can be used.

  In this embodiment, the resonance frequency change detected by each QCM is corrected based on the temperature and humidity detected by the temperature / humidity sensor 130, and is detected by the determination unit 122 described later from the corrected resonance frequency change. It is determined whether the subject contains moisture, ammonia, or a ketone body.

  The power supply circuit 140 generates required output power from the input power. The communication module 150 is used for wireless connection between the biological monitor device 100 and the portable device 220. The biological monitor device 100 is configured to be operable with a battery, for example, a lithium ion polymer secondary battery 160. The biological monitor device 100 includes a charging circuit 170 for charging the lithium ion polymer secondary battery 160 and a USB terminal 180 dedicated for charging. In addition, the biological monitor device 100 is provided with a power switch (power supply SW) 190 that turns the biological monitor device 100 on and off. For example, BLUETOOTH (registered trademark) can be used for the communication module 150.

  The information processing unit 120 includes an input unit 121, a determination unit 122, a grant unit 123, a storage unit 124, and an output unit 125.

  The input unit 120 includes an electrical signal having a resonance frequency of the first QCM 101 detected by the first frequency counter circuit 111, the second frequency counter circuit 112, and the third frequency counter circuit 113, and the second QCM 102. The electrical signal having the resonance frequency, the electrical signal having the resonance frequency of the third QCM 103, and the temperature and humidity information detected by the temperature / humidity sensor 130 are input.

  Based on the electrical signal of the resonance frequency of each QCM 101-103 and the temperature and humidity information input to the input unit 120, the determination unit 122 determines whether the detection target includes a ketone body, whether it includes ammonia, It is determined whether or not it contains moisture. The determination unit 122 determines whether the detection target is urine containing a ketone body.

  The determination unit 122 corrects the resonance frequency change of each of the QCMs 101 to 103 based on the input temperature and humidity. It is determined from the corrected resonance frequency change of the first QCM whether moisture is contained in the detection target. Further, it is determined from the corrected resonance frequency change of the second QCM whether ammonia is contained in the detection target. Further, it is determined from the corrected resonance frequency change of the third QCM whether or not a ketone body is included in the detection target.

  The assigning unit 123 generates an analysis result based on the determination result of the determination unit 122 and assigns the analysis result to the detection target. Analytical results show that urine gas containing ketone bodies is a urine gas molecule that does not contain ketone bodies, is highly likely to be gas molecules other than urine, but is not water containing urine, is highly likely to be gas molecules of water other than urine It is either a molecule.

If the providing unit 123 gives the analysis result that the detection target is a gas molecule of urine that does not contain a ketone body, the possibility that the subject is diabetic is low, or the user already knows that the subject has diabetes. For example, the analysis result that the blood glucose control is in an appropriate state is also given to the detection target.
In addition, when the providing unit 123 gives the analysis result that the detection target is a gas molecule of urine containing a ketone body, it is already known that the user is likely to be diabetic or the user is diabetic. If so, the analysis result that there is a possibility that blood glucose control is not properly performed is also given to the detection target.

  Here, when there is sufficient saccharide due to diabetes and other reasons such as lack of insulin, if sugar is not properly used as an energy source and fat is used as an energy source, a ketone body is generated, It is excreted in the urine. Ketone bodies are also present in normal urine, but in very small amounts. Although details will be described later, when the detection result of the third QCM 103 is equal to or greater than a certain amount, it is determined that the ketone body is included, and when the certain amount is not satisfied, it is determined that the ketone body is not included. Is done. In addition, even if you are diabetic, if the blood sugar is properly controlled, the ketone body will not appear in the urine more than normal, and it is determined whether the blood sugar is properly controlled by detecting the ketone body. can do.

  Thus, by detecting whether ketone bodies are contained in urine, it becomes possible to detect diabetes early, and for users who are already known to be diabetic, the state of diabetes or blood glucose control is It is an indicator of whether or not it is properly done, and can be used for physical condition management.

  The storage unit 124 stores the detection date and time, the resonance frequency change of each of the QCMs 101 to 103 input to the input unit 121 and the analysis result applied by the applying unit 123 in association with each other, and stores these data in time series.

The output unit 125 transmits the analysis result signal including the detection date and time stored in the storage unit 124, the resonance frequency change of each of the QCMs 101 to 103 input to the input unit 121, and the analysis result applied by the applying unit 123 to the communication module 150. Output to.
The analysis result signal is transmitted to the mobile device 200 as a display device via the communication module 150, and the analysis result or the like is displayed on the display unit 201 of the mobile device 200. The information processing unit 120 and the communication module 150 can transmit and receive signals, and the portable device 200 and the information processing unit 120 can transmit and receive signals through the communication module 150. In this way, the analysis result is configured to be confirmed by the user on the display unit 201 of the mobile device 200.

[Configuration and characteristics of adsorption film]
Next, the adsorption film formed on each QCM will be described. FIG. 5 is a diagram showing the adsorption characteristics of each adsorption film.

  The first adsorption film 12 formed on the first QCM 101 is an adsorption film having a characteristic of selectively adsorbing moisture gas molecules in particular. As the first adsorption film 12, a water-soluble organic film is suitable, and for example, polyvinyl alcohol can be used.

  The second adsorption film 22 formed on the second QCM 102 is an adsorption film having a characteristic of selectively adsorbing ammonia gas molecules in particular. An organic film having a functional group having a large interaction with ammonia is suitable for the second adsorption film 22. For example, ammonia can be detected using an adsorption film made of an organic material having a hydroxyl group or a phosphate group as a functional group. As an organic material having a hydroxyl group or a phosphate group as a functional group, for example, ditetradecyl phosphate can be used.

  The third adsorption film 32 formed on the third QCM 103 is an adsorption film having a characteristic of selectively adsorbing gas molecules of a ketone body in particular. A highly polar organic film is suitable for the third adsorption film 32. For example, the third adsorption film 32 is formed of a material containing a fluororesin.

  The third adsorption film 32 of the present embodiment is formed using a vinylidene fluoride resin (polyvinylidene fluoride; hereinafter referred to as PVDF) and trifluoroethylene (hereinafter referred to as TrFE) as a fluororesin. A copolymer. Specifically, PVDF and TrFE are blended so that the blending weight ratio is 8: 2, and a copolymerized powder is dissolved in methyl ketone to prepare a solution. This solution is spin-coated. After coating on the electrode 31 formed on one surface of the crystal unit 33, the solvent is volatilized in a drying furnace to form the third adsorption film 32.

PVDF has a high dielectric property because a fluorine atom can freely rotate in a linear structure in which CF ₂ and CH ₂ are alternately bonded. By using TrFE, the adsorption film 32 can be easily formed. That is, PVDF has a very high degree of crystallinity, so it is difficult to dissolve in a solvent, and even if dissolved, it easily precipitates and is difficult to handle. However, copolymerization with TrFE can suppress crystallization and facilitate film formation.

As the fluororesin, the following can be used.
For example, tetrafluoroethylene resin (polytetrafluoroethylene), tetrafluoroethylene perfluoroalkyl vinyl ether copolymer resin (perfluoroalkoxyalkane), tetrafluoroethylene-hexafluoropropylene copolymer resin (perfluoroethylene propene copolymer) ), Ethylene tetrafluoride-ethylene copolymer resin (ethylene-tetrafluoroethylene copolymer), ethylene trifluoride-ethylene copolymer resin (ethylene-chlorotrifluoroethylene copolymer), tetrafluoroethylene perfluorodioxysol A resin selected from a copolymer resin (tetrafluoroethylene-perfluorodioxole copolymer) and a vinyl fluoride resin (polyvinyl fluoride) can be used.

FIG. 4 is a diagram showing the adsorption characteristics of various gases of the QCMs 101 to 103 on which the adsorption films 12, 22, and 32 having a surface area of 0.2 cm ² and a film thickness of 1 μm are respectively formed. This characteristic evaluation was performed using a QCM measuring instrument (model number: THQ-100P) manufactured by Tama Device Co., Ltd. As gases, acetone, aqueous ammonia (10%), and moisture (humidity 80%) were used. The QCMs 101 to 103 are arranged in the QCM device, one type of gas is introduced into the QCM device one by one, and it is applied to the gas detection element at a constant flow rate, here 300 sccm, and the maximum resonance frequency change at that time is plotted. The adsorption characteristics of the adsorption films 12, 22, and 32 were evaluated.

  As shown in FIG. 4, the first adsorption film 12 of the first QCM 101 particularly adsorbs ammonia water and moisture well, and the second adsorption film 22 of the second QCM 102 particularly adsorbs gas molecules of ammonia water. . The third adsorption film 32 of the third QCM 103 selectively adsorbs acetone gas molecules. As shown in FIG. 4, the second adsorption film 22 used for the second QCM and the third adsorption film 32 used for the third QCM are low in moisture adsorbability and highly accurate without being affected by the humidity environment. Detection is possible.

  Thus, the adsorption film of each QCM is made different, and based on the detection results of these QCMs, whether the detection target contains water, whether it contains ammonia, or whether it contains acetone, which is a ketone body. Can be determined. Based on the determination result, the detection target is not urine and water other than urine, but the possibility of gas molecules is high, the possibility of gas molecules of water other than urine is high, and acetone-free urine gas It is possible to analyze whether the molecule is a urine gas molecule containing acetone. A specific analysis method will be described below.

[Analysis method]
FIG. 3 shows an analysis method using the above-described biological monitor device 100. Table 1 shows the relationship between the combination pattern of the detection result of each QCM and the determination.

  In the biological monitor device 100 of the present embodiment, the determination unit 122 determines that moisture is included in the detection target when the corrected resonance frequency change of the first QCM 101 is 250 Hz or more, and the corrected resonance frequency change is detected. When the frequency is less than 250 Hz, it is determined that the detection target does not contain moisture.

  The determination unit 122 determines that ammonia is included in the detection target when the corrected resonance frequency change of the second QCM 102 is 100 Hz or more, and the detection target is determined when the corrected resonance frequency change is less than 100 Hz. Is determined not to contain ammonia.

  The determination unit 122 determines that acetone, which is a ketone body, is included in the detection target when the resonance frequency change after correction of the third QCM is 100 Hz or more, and the correction of the resonance frequency after correction is less than 100 Hz. In this case, it is determined that acetone, which is a ketone body, is not included in the detection target.

  The relationship between the combination pattern of the detection results of each QCM and the determination will be described using Table 1. In Table 1, moisture is detected in the first adsorbing film 12, ammonia is detected in the second adsorbing film 22, acetone is detected in the third adsorbing film 32, ◯ is detected, and x indicates no detection.

In pattern 1, which is the result of detection in any adsorbed film, the detection target is urine gas molecules containing acetone, and human urine or blood glucose control with high possibility of diabetes is appropriately managed. Analyzed to be urine gas molecules likely to be urine of non-diabetic patients.
In pattern 2, which is a result of detection by the first adsorption film 12 and the second adsorption film 22 and no detection by the third adsorption film 32, the detection target is a urine gas molecule not containing acetone, Analyzed to be gas molecules in human urine with a low probability of diabetes, or in urine of diabetics whose glycemic control is appropriately controlled.

In pattern 3, which is a result of detection not performed by the first adsorption film 12 and the second adsorption film 22 and detection by the third adsorption film 32, the detection target is not urine or moisture other than urine but gas molecules. Analyzed as likely.
In the pattern 4 which is a result of the detection without the first adsorption film 12 and the third adsorption film 32 and the detection with the second adsorption film 22, the detection target is not urine or moisture other than urine but the gas molecule Analyzed as likely.
In pattern 5 which is the result of no detection in any of the adsorbed films, it is analyzed that the detection target is not urine and water other than urine but the possibility of gas molecules is high.
In pattern 6, which is the result of no detection by the first adsorption film 12 and the detection by the second adsorption film 22 and the third adsorption film 32, the detection target is urine and the gas molecules of which are not moisture other than urine. Analyzed as likely.

  In pattern 7, which is a result of detection by the first adsorption film 12 and the third adsorption film 32 and no detection by the second adsorption film 22, there is a high possibility that the detection target is a gas molecule of moisture other than urine. It is determined. In the pattern 8 which is a result detected by the first adsorption film 12 and not detected by the second adsorption film 22 and the third adsorption film 32, there is a high possibility that the detection target is a gas molecule of moisture other than urine. Is analyzed.

Next, a method for analyzing urine using the above-described biological monitor device 100 will be described with reference to FIG.
In the biological monitor device 100, when gas molecules to be detected flow, the first QCM 101, the second QCM 102, and the third QCM 103 adsorb the gas molecules. The first frequency counter circuit 111, the second frequency counter circuit 112, and the third frequency counter circuit 113 detect the resonance frequencies of the first QCM 101, the second QCM 102, and the third QCM 103, respectively. From each of the frequency counter circuits 111 to 113, an electrical signal having the detected resonance frequency is output to the information processing unit 120.

  The input unit 120 includes a resonance frequency of the first QCM 101, a resonance frequency of the second QCM 102, a resonance frequency of the second QCM 102 detected by the first frequency counter circuit 111, the second frequency counter circuit 112, and the third frequency counter circuit 113, respectively. 3 and the temperature and humidity detected by the temperature / humidity sensor 130 are input.

The determination unit 122 corrects the electrical signals of the resonance frequencies of the QCMs 101 to 103 input to the input unit 120 based on the temperature and humidity information.
Next, the determination unit 122 determines whether or not the corrected resonance frequency change of the first QCM 101 is 250 Hz or more, that is, whether or not the detection target includes moisture (S101). When the determination unit 122 determines No in S <b> 101, the application unit 123 provides an analysis result indicating that there is a high possibility of gas molecules although it is not water containing urine, and the analysis ends.

If the determination unit 122 determines Yes in S101, the process proceeds to S102. In S102, it is determined whether or not the corrected resonance frequency change of the second QCM 102 is 100 Hz or more, that is, whether or not the detection target contains ammonia.
When the determination unit 122 determines No in S102, the applying unit 123 adds the analysis result that is a gas molecule of moisture other than urine to the detection target, and the analysis ends.

If the determination unit 122 determines Yes in S102, the process proceeds to S103. In S103, it is determined whether or not the corrected resonance frequency of the third QCM 103 is 100 Hz or more, that is, whether or not acetone is included.
If the determination unit 122 determines No in S103, the grant unit 123 analyzes that the urine gas molecule does not contain acetone and has a low possibility of diabetes, or that blood glucose control is in an appropriate state. Is added to the detection target, and the analysis ends.

  When the determination unit 122 determines Yes in S103, the grant unit 123 detects an analysis result indicating that it is a urine gas molecule containing acetone and possibly having diabetes, or that blood glucose control is not in an appropriate state. It is given to the subject and the analysis ends.

As described above, in this embodiment, urine containing acetone as a detection target using the first detection element for detecting moisture, the second detection element for detecting ammonia, and the third detection element for detecting acetone. It can be determined whether it is a gas molecule.
Thereby, when it is determined that the detection target is a urine gas molecule containing acetone, the detection target is likely to be a urine gas molecule of a diabetic human, and the urine is likely to contain urine sugar. Is analyzed. Based on the analysis result, early detection of diabetes is possible, and it can be confirmed whether or not the blood glucose control of the diabetic patient is appropriately managed, and can be used for physical condition management. In addition, when it is determined that the detection target is a urine gas molecule that does not contain acetone, the user is less likely to have diabetes, or blood glucose control is performed for a user who is already known to have diabetes. It is analyzed that it is properly managed and can be used for physical condition management.

  In this embodiment, since the health management state related to diabetes is determined by analyzing urine gas molecules, it is not necessary to collect urine, and it is not necessary to provide a urine collecting means and a washing mechanism for washing the urine. Analysis can be performed easily.

As mentioned above, although embodiment of this invention was described, this invention is not limited only to the above-mentioned embodiment, Of course, a various change can be added.
For example, in the above-described embodiment, QCM is used as a detection element to detect gas molecules of acetone, ammonia, and moisture, but other ketone bodies may be detected instead of acetone.

Further, in the above-described embodiment, the analysis result is configured to be visible by a display device provided separately from the biological monitor device 100, and the display unit notifies the user of the analysis result by image display. Although it is a means, it is not limited to this.
For example, a display unit (notification unit) may be provided in the biological monitor device 100 so that the analysis result is displayed.

  In addition, as a notification means in another form of notification by the display unit, a lamp or a speaker may be provided, or notification may be performed by lighting of the lamp or sound from the speaker. These notification units perform notification based on the detection result given to the detection target by the grant unit 123. In addition, each notification means such as a lamp, a speaker, a display unit of a display device such as a portable device arranged outside the biological monitor device, and a display unit provided in the biological monitor device may be provided alone or in plural. You may combine.

  In the notification by lighting the lamp, for example, when acetone is detected in a state where urination is detected (both ammonia and moisture are detected), a red lamp is lit and no acetone is detected. In this case, the green lamp is turned on. The lighting of the red lamp indicates a warning that there is a possibility of diabetes, and the lighting of the green lamp indicates that the possibility of diabetes is low.

  Also, in the audio notification, if acetone is detected in a state where urination is detected (a state where both ammonia and water are detected), “There is a possibility of diabetes” or “blood glucose” from the speaker. If the control is not working properly, you hear a voice, and if no acetone is detected, configure the voice to play, saying "The chance of diabetes is low" or "The blood sugar control is working well." be able to.

  As described above, the user can confirm the analysis result of urine in real time by using a display unit, a speaker, a lamp, or the like provided in a portable device or a living body monitor device, which can be used for early detection of diabetes and physical condition management.

As for the place where the detection element is installed, it can be installed in any place where the volatile components of urine can be detected in the toilet and where urine is not directly applied. It can also be provided on a wall or the like.
In the above-described embodiment, the resonance frequency detected from the first QCM 101 that adsorbs moisture in the air is corrected based on the humidity detected by the temperature / humidity sensor, and is detected from the corrected resonance frequency. Although it was determined whether or not the subject contains moisture, the present invention is not limited to this. For example, the time-dependent change of the resonance frequency detected from the first QCM 101 is monitored, and it is assumed that the time when the resonance frequency suddenly increases is the time when urine or water other than urine is put into the toilet. It is good also as determination of whether moisture is contained in.

12 1st adsorption film 13 1st vibrator 22 2nd adsorption film 23 2nd vibrator 32 3rd adsorption film 33 3rd vibrator 100 living body monitor device 101 1st detection element (1st QCM)
102 Second detection element (second QCM)
103 3rd detection element (3rd QCM)
122 determination unit

Claims (11)

A first detection element for detecting moisture from a detection target;
A second detection element for detecting ammonia from the detection target;
A third detection element for detecting a ketone body from the detection target;
A biological monitor apparatus comprising: a determination unit that determines whether the detection target is urine containing a ketone body based on detection results of the first, second, and third detection elements. The biological monitor apparatus according to claim 1, wherein the determination unit determines whether or not moisture is contained in the detection target based on a detection result of the first detection element. The biological monitor device according to claim 2,
If the determination unit determines that the detection target contains moisture based on the detection result of the first detection element, does the detection target include ammonia based on the detection result of the second detection element? A biological monitor device that determines whether or not. The biological monitor device according to claim 3,
When the determination unit determines that the detection target includes ammonia based on the detection result of the second detection element, the detection target includes a ketone body based on the detection result of the third detection element. A biological monitor device that determines whether or not. The biological monitor device according to any one of claims 1 to 4,
A biological monitor device further comprising an adding unit that adds an analysis result to the detection target based on a determination result by the determination unit. It is a living body monitor device given in any 1 paragraph of Claims 1-5,
The biological monitor apparatus, wherein at least one of the first detection element, the second detection element, and the third detection element includes a vibrator and an adsorption film provided on the vibrator. The biological monitor device according to claim 6,
The first detection element includes: a first vibrator; and a first adsorption film that adsorbs the moisture gas molecules made of polyvinyl alcohol provided on the first vibrator. The biological monitor device according to claim 6 or 7,
The second detection element adsorbs the ammonia gas molecules made of an organic material having, as a sensitive group, a hydroxyl group or a phosphate group provided on the second transducer and the second transducer. A biological monitor device having an adsorption film. The biological monitor device according to any one of claims 6 to 8,
The third detection element is configured to adsorb gas molecules of the ketone body formed using a third vibrator, a vinylidene fluoride resin provided on the third vibrator and trifluoroethylene. A biological monitor device having 3 adsorption films. From the detection target, water, ammonia and ketone bodies are detected,
A method for analyzing urine that analyzes whether or not the detection target is urine containing a ketone body based on the detection result. A method for analyzing urine according to claim 10,
A method for analyzing urine, wherein when the detection target is analyzed as urine containing a ketone body, the detection target is analyzed as urine having a high possibility of containing urine sugar.

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