JP6817808B2 - Biological monitoring device and urine analysis method - Google Patents

Description

The present invention relates to a biological monitoring device and a method for analyzing urine.

A health management device that can analyze urine that can be attached to a Western-style toilet installed in a toilet and support an individual's health check has been proposed (see, for example, Patent Document 1, Patent Document 2, and Patent Document 3). .). This health management device is provided with urine collection means and is configured to analyze the collected urine.

Japanese Unexamined Patent Publication No. 7-209289 Japanese Unexamined Patent Publication No. 10-267925 JP-A-2000-310631

In the above-mentioned health management device, in order to analyze the urine itself, it is necessary to provide a urine collecting means, and a large-scale configuration such as providing a washing mechanism for cleaning the urine collecting means is required.

In view of the above circumstances, an object of the present invention is to provide a biological monitoring device and a urine analysis method capable of easily determining a health management state related to diabetes.

In order to achieve the above object, the biological monitoring device according to one embodiment of the present invention includes a first detection element, a second detection element, a third detection element, and a determination unit.
The first detection element detects moisture from the detection target.
The second detection element detects ammonia from the detection target.
The third detection element detects a ketone body from the detection target. The determination unit detects a ketone body based on the detection results of the first, second, and third detection elements. It is determined whether or not the urine contains.

According to such a configuration of the present invention, it is possible to determine whether or not the detection target is urine containing ketone bodies, and whether or not diabetes can be detected early, the state of diabetes and blood glucose control can be appropriately controlled. It is possible to easily manage the physical condition such as.

That is, the first and second detection elements can determine whether or not the detection target is urinated urine.

When water is not detected by the first detection element and ammonia is detected by the second detection element, for example, the detection target can be determined to be the odor of urine adhering to the toilet. On the other hand, when water is detected by the first detection element and ammonia is detected by the second detection element, it can be determined that the detection target is a volatile component of urinated urine.

Further, when water is detected by the first detection element and ammonia is not detected by the second detection element, it can be determined that the detection target is a gas molecule of water other than urine. On the other hand, when water is detected by the first detection element and ammonia is detected by the second detection element, it can be determined that the detection target is a gas molecule of urine in the liquid urinated.

In this way, the first and second detection elements can determine whether or not the detection target is urinated urine. As a result, it is possible to reduce the occurrence of erroneous detection of erroneously detecting something that is not derived from urinated urine, and it is possible to perform highly accurate detection.

Then, by detecting whether or not the urinated urine contains ketone bodies, early detection of diabetes and physical condition management can be easily performed.
Here, acetone, acetoacetic acid, and hydroxybutyric acid are produced when fat is decomposed and used as an energy source, and are collectively called ketone bodies. Ketone bodies are generated and excreted in urine when fat is used as an energy source because sugar cannot be used properly as an energy source even though there is sufficient sugar due to diabetes or other reasons such as lack of insulin. Will be done. Therefore, by detecting urine containing ketone bodies, it is presumed that the urine is human urine that may have diabetes, which leads to early detection of diabetes. In addition, even in diabetes, if blood glucose is well controlled, more ketone bodies will not appear in the urine than in normal times. Therefore, in humans who are already known to have diabetes, it is possible to determine whether or not glycemic control is properly managed based on the presence or absence of detection of ketone bodies in urine, which can be useful for physical condition management. ..

The determination unit may determine whether or not the detection target contains water based on the detection result of the first detection element.
Thereby, it can be determined whether or not the detection target is urine and water other than urine.

When the determination unit determines that the detection target contains water based on the detection result of the first detection element, whether the detection target contains ammonia based on the detection result of the second detection element. It may be determined whether or not.
Thereby, it is possible to determine whether the detection target is urinating urine or water other than urine.

When the determination unit determines that ammonia is contained in the detection target based on the detection result of the second detection element, the detection target contains a ketone body based on the detection result of the third detection element. It may be determined whether or not.
Thereby, it is possible to determine whether the detection target is urine containing a ketone body or urine containing no ketone body.

Based on the determination result by the determination unit, an addition unit that gives the analysis result to the detection target may be further provided.

At least one of the first detection element, the second detection element, and the third detection element may have an oscillator and an adsorption film provided on the oscillator.
As described above, a QCM (Quartz Crystal Microbalance) sensor element may be used as the detection element.

The first detection element may have a first vibrator and a first adsorption film for adsorbing gas molecules of the water content made of polyvinyl alcohol provided on the first vibrator.
As described above, the QCM sensor element can be used as the first detection element, and the water content can be detected by using the first adsorption film made of polyvinyl alcohol.

The second detection element adsorbs the gas molecule of ammonia composed of the second oscillator and an organic material having a hydroxyl group or a phosphate group provided on the second oscillator as a sensitive group. May have an adsorption film of.
As described above, the QCM sensor element can be used as the second detection element, and ammonia can be detected by using the second adsorption film made of an organic material having a hydroxyl group or a phosphoric acid group as a functional group. As the organic material having a hydroxyl group or a phosphoric acid group as a functional group, for example, ditetradecylphosphoric acid or the like can be used.

The third detection element adsorbs the gas molecule of the ketone body formed by using the third oscillator and the vinylidene fluoride resin and trifluoroethylene provided on the third oscillator. It may have 3 adsorption membranes.
As described above, the QCM sensor element can be used as the third detection element, and the ketone body acetone is detected by using the third adsorption film formed by using vinylidene fluoride resin and trifluoroethylene. be able to.

In order to achieve the above object, the urine analysis method according to one embodiment of the present invention detects ketone bodies, ammonia and water from the detection target, and based on the detection result, the detection target is urine containing a ketone body. Analyze if it exists.

When the detection target is analyzed to be a gas molecule of urine containing a ketone body, it may be analyzed that the detection target is urine having a high possibility of containing urine sugar.
By detecting ketone bodies in urine in this way, it can be analyzed that the detection target is a gas molecule of human urine having a high possibility of diabetes, and urine has a high possibility of containing urine sugar.

As described above, according to the present invention, it is possible to obtain a biological monitoring device and a urine analysis method capable of easily determining whether or not the detection target is urine containing ketone bodies.

It is a figure which shows the structure of the biological monitor system using the biological monitor device which concerns on embodiment of this invention. It is a figure which shows the structure of the biological monitoring device shown in FIG. It is a flowchart which shows the detection method of the biological monitoring apparatus shown in FIG. It is a figure which shows the adsorption characteristic of each detection element provided in the biological monitoring apparatus shown in FIG.

Hereinafter, embodiments of the present invention will be described with reference to the drawings. FIG. 1 shows the configuration of a biological monitor system using a biological monitor device. FIG. 2 shows the configuration of the biological monitoring device. The biological monitoring device 100 is configured to be mounted on the back of the toilet seat of a Western-style toilet, for example.
The biological monitoring device 100 detects water, ammonia, and ketone bodies from the detection target, and determines whether or not the detection target is urine containing ketone bodies based on the detection results. The analysis result generated based on the determination result can be confirmed by the user on a display device such as a portable device described later. In addition, the analysis results are configured to be memorable in time series in association with the detection date and time, and the user can manage the physical condition by checking the analysis results in time series on the display device.

The biological monitor system includes a biological monitor device 100 and a portable device 200 as a display device having a display unit 201 for the result detected by the biological monitor device 100. The portable device 200 and the biological monitoring device 100 can wirelessly transmit signals using a communication module.

[Configuration of biological monitoring device]
The biological monitoring device 100 includes a substrate (not shown), a first QCM sensor element (hereinafter referred to as a first QCM) 101 as a first detection element, and a second QCM sensor element 101 as a second detection element. The QCM sensor element (hereinafter referred to as the second QCM) 102, the third QCM sensor element (hereinafter referred to as the third QCM) 103 as the third detection element, and the first frequency counter circuit 111. , The second frequency counter circuit 112, the third frequency counter circuit 113, the information processing unit 120, the temperature / humidity sensor 130, the power supply circuit 140, the communication module 150, the lithium ion polymer secondary battery 160, and the like. It includes a charging circuit 170, a USB terminal 180 dedicated to charging, and a power switch (power SW) 190.

Each of the three QCM 101 to 103 has a configuration including a crystal oscillator as an oscillator and an adsorption film for adsorbing a specific gas provided on the crystal oscillator, and the type of adsorption film is different. The basic structure is the same, only different. Since the resonance frequency of the crystal oscillator decreases in proportion to the weight of the gas adsorbed on the adsorption film, the amount of change in the resonance frequency is measured for each crystal oscillator, and based on this measurement result, water and ammonia are detected. , It is possible to detect whether or not a ketone body is contained.

In the present embodiment, a crystal oscillator having a resonance frequency of 9 MHz is used as the detection element, but the detection element is not limited to this. For example, in addition to the crystal oscillator, a ceramic oscillator, surface acoustic wave element, cantilever, diaphragm, etc. can also be used to detect physical changes such as weight increase and expansion stress increase due to gas adsorption of the adsorption membrane and convert them into electrical signals. Applicable if possible.

The first QCM101 (second QCM102, third QCM103) includes a first crystal oscillator 13 (second crystal oscillator 23, third crystal oscillator 33) and electrodes 11 (21, 31). The first adsorption film 12 (second adsorption film 22, third adsorption film 32), lead land 16A (26A, 36A), lead land 16B (26B, 36B), and lead 14A (24A, 34A), leads 14B (24B, 34B), pin terminals 19A (29A, 39A), and pin terminals 19B (29B, 39B). The crystal oscillators 13 (23, 33) are AT-cut crystal plates.

The electrodes 11 (21, 31) are formed on both surfaces of the crystal oscillator 13 (23, 33), and the adsorption film 12 (22, 32) is formed on one surface of the crystal oscillator 13 (23, 33). It is formed on the electrodes 11 (21, 31). The lead land 16A (26A, 36A) is integrally formed with the electrode 11 (21, 31) formed on one surface, and the lead land 16B (26B, 36B) is formed on the other surface. , 31) are integrally formed.

Leads 14A (24A, 34A) and leads 14B (24B, 34B) are made of metal spring material and are arranged parallel to each other.
One end of the lead 14A (24A, 34A) is electrically connected to the electrode 11 (21, 31) formed on one surface via the lead land 16A (26A, 36A), and the other end is a pin terminal 19A ( Connect to 29A, 39A). One end of the lead 14B (24B, 34B) is electrically connected to the electrode 11 (21, 31) formed on the other surface via the lead land 16B (26B, 36B), and the other end is a pin terminal 19B (29B). , 39B).

The pin terminals 19A (29A, 39A) and the pin terminals 19B (29B, 39B) are supported by a terminal block 18 (28, 38) provided on the substrate, and the crystal unit is supported by the terminal block 18 (28, 38). 13 (23, 33) is oscillatedly supported.

The pin terminals 19A (29A, 39A) and 19B (29B, 39B) of the QCM101 (102, 103) are connected to an oscillation circuit (not shown), and a drive voltage is applied to the QCM101 (102, 103). When a driving voltage is applied to the QCM 101 (102, 103), the crystal oscillator 13 (23, 33) vibrates at a unique resonance frequency (9 MHz in this example).

Then, the mass of the adsorption film 12 (22, 32) changes due to the adsorption of the gas, and the oscillation frequency of the crystal oscillator 13 (23, 33) decreases according to the amount of the adsorption. The first QCM101, the second QCM102, and the third QCM103 are connected to the first frequency counter circuit 111, the second frequency counter circuit 112, and the third frequency counter circuit, respectively. The first frequency counter circuit 111 (second frequency counter circuit 112, third frequency counter circuit 113) detects the resonance frequency of the first QCM 101 (second QCM 102, third QCM 103). From each frequency counter circuit 111 to 113, an electric signal of the detected resonance frequency is output to the information processing unit 120.

The first QCM101 detects water, the second QCM102 detects ammonia, and the third QCM103 detects ketone bodies. The adsorption films 12, 22, and 32 formed on the QCM 101 to 103 are made of different materials and have different adsorption characteristics. The details of the adsorption membrane will be described later.

The temperature / humidity sensor 130 detects the temperature and humidity of the atmosphere in which the biological monitoring device 100 is placed. Depending on the type of adsorption membrane, the resonance frequency detected varies greatly due to changes in the temperature or humidity of the atmosphere.
In the present embodiment, the resonance frequency detected by each of the QCMs 101 to 103 is corrected so as to cancel the resonance frequency change due to the temperature, based on the temperature detected by the temperature / humidity sensor 130. The data of the resonance frequency change according to the temperature is stored in advance in the storage unit 124 of the information processing unit 120, which will be described later, for each adsorption film.

Further, based on the humidity detected by the temperature / humidity sensor 130, the resonance frequency detected by each of the QCMs 101 to 103 is corrected so as to cancel the resonance frequency change due to the humidity. The data of the resonance frequency change according to the humidity is stored in advance in the storage unit 124 of the information processing unit 120, which will be described later, for each adsorption film.

In the first QCM 101, the resonance frequency is corrected by using the humidity detected when urine or water other than urine is not put into the toilet. The first adsorption film 12 of the first QCM101 is a detection element having a property of adsorbing moisture, adsorbs moisture in the air in addition to urine, and the resonance frequency changes depending on the humidity in the air. Therefore, even when the toilet is not used and urination is not performed, moisture may be detected by the humidity in the air. Therefore, in the present embodiment, the resonance frequency detected by the first QCM is corrected so as to cancel the change in the resonance frequency due to the humidity detected when urine or water other than urine is not put into the toilet. Thereby, it can be determined whether or not urine or water other than urine is put into the toilet without being affected by the humidity in the air. Whether or not urine or water other than urine is being put into the toilet can be determined by monitoring the time-dependent change in humidity detected by the temperature / humidity sensor 130. If the humidity detected by the temperature / humidity sensor 130 changes suddenly, it is determined that urine or water other than urine is being put into the toilet, and it is based on the humidity at the stage before the sudden change in humidity occurs. It is possible to correct the change in resonance frequency.

In the second QCM 102 and the third QCM 103, the resonance frequency is corrected using the humidity detected when urine or water other than urine is put into the toilet.

For the temperature / humidity sensor 130, for example, a digital temperature / humidity sensor (model number: SHT21) manufactured by Sencilion Co., Ltd. can be used.

In the present embodiment, the resonance frequency change detected by each QCM is corrected based on the temperature and humidity detected by the temperature / humidity sensor 130, and the corrected resonance frequency change is detected by the determination unit 122 described later. Whether or not the subject contains water, ammonia, or ketone bodies is determined.

The power supply circuit 140 produces the required output power from the input power. The communication module 150 is used for wireless connection between the biological monitoring device 100 and the portable device 220. The biological monitoring device 100 is configured to be operable by a battery, for example, a lithium ion polymer secondary battery 160. The biological monitoring device 100 includes a charging circuit 170 for charging the lithium ion polymer secondary battery 160 and a USB terminal 180 dedicated to charging. Further, the biological monitoring device 100 is provided with a power switch (power SW) 190 for turning on / off the power of the biological monitoring device 100. For the communication module 150, for example, BLUETOOTH (registered trademark) or the like can be used.

The information processing unit 120 includes an input unit 121, a determination unit 122, an imparting unit 123, a storage unit 124, and an output unit 125.

The input unit 120 includes an electric signal having a resonance frequency of the first QCM 101 detected by each of the first frequency counter circuit 111, the second frequency counter circuit 112, and the third frequency counter circuit 113, and the second QCM 102. The electric signal of the resonance frequency, the electric signal of the resonance frequency of the third QCM 103, and the temperature and humidity information detected by the temperature / humidity sensor 130 are input.

The determination unit 122 determines whether or not the detection target contains ketone bodies and whether or not ammonia is contained, based on the electrical signal of the resonance frequency of each QCM 101 to 103 input to the input unit 120 and the temperature and humidity information. Determine if it contains water. The determination unit 122 determines whether or not the detection target is urine containing ketone bodies.

The determination unit 122 corrects the resonance frequency change of each QCM 101 to 103 based on the input temperature and humidity. From the corrected resonance frequency change of the first QCM, it is determined whether or not the detection target contains water. In addition, it is determined whether or not ammonia is contained in the detection target from the corrected resonance frequency change of the second QCM. Further, it is determined from the corrected resonance frequency change of the third QCM whether or not a ketone body is contained in the detection target.

The granting unit 123 generates an analysis result based on the determination result of the determination unit 122, and assigns the analysis result to the detection target. The analysis results show that there is a high possibility of gas molecules that are not water containing urine, there is a high possibility of gas molecules of water other than urine, urine gas molecules that do not contain ketone bodies, and urine gas that contains ketone bodies. It is either a molecule.

If the granting unit 123 grants the analysis result that the detection target is a gas molecule of urine containing no ketone body, it is unlikely that the patient has diabetes, or the user already knows that the patient has diabetes. For example, the analysis result that the blood glucose control is in an appropriate state is also given to the detection target.
Further, when the imparting unit 123 imparts an analysis result that the detection target is a gas molecule of urine containing a ketone body, it is already known that the user is likely to have diabetes or the user is diabetic. If so, the analysis result that there is a possibility that the blood glucose is not properly controlled is also given to the detection target.

Here, if sugar is not properly used as an energy source and fat is used as an energy source even though there is sufficient sugar due to reasons such as lack of insulin due to diabetes or the like, ketone bodies are generated. Excreted in urine. Ketone bodies are also present in normal urine, but in very small amounts. Details will be described later, but if the detection result of the third QCM103 is a certain amount or more, it is determined that a ketone body is contained, and if it does not satisfy a certain amount, it is determined that a ketone body is not contained. Will be done. In addition, even in diabetes, if the blood glucose is properly controlled, more ketone bodies will not appear in the urine than in the normal state, and the detection of ketone bodies will determine whether or not the blood glucose is properly controlled. can do.

In this way, by detecting whether or not ketone bodies are contained in urine, early detection of diabetes is possible, and for users who are already known to have diabetes, the diabetic condition or glycemic control can be controlled. It can be used as an index of whether or not it is done properly and can be used for physical condition management.

The storage unit 124 stores the detection date and time, the resonance frequency change of each QCM 101 to 103 input to the input unit 121, and the analysis result given by the imparting unit 123 in association with each other, and stores these data in time series.

The output unit 125 transmits an analysis result signal including the detection date and time stored by the storage unit 124, the resonance frequency change of each QCM 101 to 103 input to the input unit 121, and the analysis result given by the addition unit 123 to the communication module 150. Output to.
The analysis result signal is transmitted to the portable device 200 as a display device via the communication module 150, and the analysis result and the like are displayed on the display unit 201 of the portable device 200. Further, the information processing unit 120 and the communication module 150 can transmit and receive signals, and the mobile device 200 and the information processing unit 120 can transmit and receive signals via the communication module 150. In this way, the analysis result can be confirmed by the user on the display unit 201 of the mobile device 200.

[Structure and characteristics of adsorption membrane]
Next, the adsorption film formed on each of the above-mentioned QCMs will be described. FIG. 5 is a diagram showing the adsorption characteristics of each adsorption film.

The first adsorption film 12 formed on the first QCM 101 is an adsorption film having a property of selectively adsorbing gas molecules of water in particular. A water-soluble organic film is suitable for the first adsorption film 12, and for example, polyvinyl alcohol can be used.

The second adsorption film 22 formed on the second QCM 102 is an adsorption film having a property of selectively adsorbing gas molecules of ammonia in particular. As the second adsorption membrane 22, an organic membrane having a functional group having a large interaction with ammonia is suitable. For example, ammonia can be detected using an adsorption membrane made of an organic material having a hydroxyl group or a phosphoric acid group as a functional group. As the organic material having a hydroxyl group or a phosphoric acid group as a functional group, for example, ditetradecylphosphoric acid or the like can be used.

The third adsorption film 32 formed on the third QCM 103 is an adsorption film having a property of selectively adsorbing gas molecules of ketone bodies in particular. A highly polar organic film is suitable for the third adsorption film 32. For example, the third adsorption film 32 is formed of a material containing a fluororesin.

The third adsorption film 32 of the present embodiment is formed by using vinylidene fluoride resin (polyvinylidene fluoride; hereinafter referred to as PVDF) and trifluoroethylene (hereinafter referred to as TrFE) as the fluororesin. Consists of a copolymer. Specifically, PVDF and TrFE are blended so that the blending weight ratio is 8: 2, and the copolymerized powder is dissolved with methyl ketone to prepare a solution, and this solution is spin-coated. After coating on the electrode 31 formed on one surface of the crystal transducer 33, the solvent is volatilized in a drying furnace to form a third adsorption film 32.

PVDF has a linear structure in which CF ₂ and CH ₂ are alternately bonded, and has high dielectric properties due to the free rotation of fluorine atoms. By using TrFE, the film formation of the adsorption film 32 becomes easy. That is, since PVDF has a very high crystallinity, it is difficult to dissolve in a solvent, and even if it is dissolved, it easily precipitates and is difficult to handle. However, by copolymerizing with TrFE, crystallization can be suppressed and film formation becomes easy.

The following can be used as the fluororesin.
For example, tetrafluoroethylene resin (polytetrafluoroethylene), tetrafluoroethylene perfluoroalkyl vinyl ether copolymer resin (perfluoroalkoxyalkane), tetrafluoroethylene-propylene hexafluoropropylene copolymer resin (perfluoroethylene propene copolymer). ), Tetrafluoroethylene-ethylene copolymer resin (ethylene-tetrafluoroethylene copolymer), ethylene trifluorochloride-ethylene copolymer resin (ethylene-chlorotrifluoroethylene copolymer), ethylene tetrafluoroethylene / perfluorodioxysole A resin selected from a copolymer resin (tetrafluoroethylene-perfluorodioxol copolymer) and a vinyl fluoride resin (polyvinyl fluoride) can be used.

FIG. 4 is a diagram showing the adsorption characteristics of various gases of QCM 101 to 103 on which adsorption films 12, 22, and 32 formed to have a surface area of 0.2 cm ² , 1 μm, respectively, are formed. This characteristic evaluation was performed using a QCM measuring instrument (model number: THQ-100P) manufactured by Tama Device Co., Ltd. As the gas, acetone, aqueous ammonia (10%), and water (humidity 80%) were used. QCM101 to 103 are arranged in the QCM device, one type of gas is introduced into the QCM device, and the gas is applied to the gas detection element at a constant flow rate, here, a flow rate of 300 sccm, and the maximum resonance frequency change at that time is plotted. , The adsorption characteristics of the adsorption films 12, 22 and 32 were evaluated.

As shown in FIG. 4, the first adsorption membrane 12 of the first QCM101 particularly well adsorbs ammonia water and water, and the second adsorption membrane 22 of the second QCM102 particularly adsorbs gas molecules of ammonia water. .. The third adsorption film 32 of the third QCM 103 selectively adsorbs the gas molecules of acetone. As shown in FIG. 4, the second adsorption film 22 used for the second QCM and the third adsorption film 32 used for the third QCM have low adsorption property to moisture and high accuracy that is not so affected by the humidity environment. It can be detected.

In this way, the adsorption film of each QCM is made different, and based on the detection results of these QCMs, whether or not the detection target contains water, whether or not it contains ammonia, and whether or not it contains acetone, which is a ketone body. Can be determined. Then, based on this determination result, the detection target is a gas molecule of water other than urine, which is not water, but is likely to be a gas molecule of water other than urine, and a gas of urine containing no acetone. It is possible to analyze whether it is a molecule or a gas molecule of urine containing acetone. The specific analysis method will be described below.

[Analysis method]
FIG. 3 shows an analysis method using the above-mentioned biological monitoring device 100. Table 1 shows the relationship between the combination pattern of the detection results of each QCM and the determination.

In the biological monitoring device 100 of the present embodiment, when the corrected resonance frequency change of the first QCM 101 is 250 Hz or more, the determination unit 122 determines that the detection target contains water, and the corrected resonance frequency change is If it is less than 250 Hz, it is determined that the detection target does not contain water.

Further, the determination unit 122 determines that the detection target contains ammonia when the corrected resonance frequency change of the second QCM 102 is 100 Hz or more, and when the corrected resonance frequency change is less than 100 Hz, the detection target. Is determined to be free of ammonia.

Further, when the resonance frequency change after the correction of the third QCM is 100 Hz or more, the determination unit 122 determines that the detection target contains acetone, which is a ketone body, and the resonance frequency change after the correction is less than 100 Hz. In this case, it is determined that the detection target does not contain acetone, which is a ketone body.

Table 1 will be used to explain the relationship between the pattern of the combination of the detection results of each QCM and the determination. In Table 1, moisture was detected in the first adsorption film 12, ammonia was detected in the second adsorption film 22, and acetone was detected in the third adsorption film 32. ◯ indicates that it was detected, and × indicates that it was not detected.

In pattern 1, which is the result of detection in any of the adsorption membranes, the detection target is urine gas molecules containing acetone, and human urine with a high possibility of diabetes or glycemic control is appropriately managed. It is analyzed as a gas molecule of urine that is likely to be the urine of a diabetic who has not.
In pattern 2, which is the result of detection by the first adsorption membrane 12 and the second adsorption membrane 22 and no detection by the third adsorption membrane 32, the detection target is a gas molecule of urine that does not contain acetone. It is analyzed as a gas molecule in human urine, which is unlikely to be diabetic, or in urine of diabetic patients whose glycemic control is well controlled.

In pattern 3, which is the result of no detection by the first adsorption membrane 12 and the second adsorption membrane 22 and detection by the third adsorption membrane 32, the detection target is urine and gas molecules other than urine, which are not water. It is analyzed that it is likely.
In pattern 4, which is the result of no detection by the first adsorption membrane 12 and the third adsorption membrane 32 and detection by the second adsorption membrane 22, the detection target is urine and gas molecules other than urine, which are not water. It is analyzed that it is likely.
In pattern 5, which is the result of no detection in any of the adsorption membranes, it is analyzed that the detection target is likely to be urine and gas molecules other than urine, although they are not water.
In pattern 6, which is the result of no detection by the first adsorption membrane 12 and detection by the second adsorption membrane 22 and the third adsorption membrane 32, the detection target is urine and gas molecules other than urine, which are not water. It is analyzed that it is likely.

In pattern 7, which is the result of detection by the first adsorption membrane 12 and the third adsorption membrane 32 and not by the second adsorption membrane 22, it is highly possible that the detection target is a gas molecule of water other than urine. Is determined. In pattern 8, which is the result of detection by the first adsorption membrane 12 and no detection by the second adsorption membrane 22 and the third adsorption membrane 32, it is highly possible that the detection target is a gas molecule of water other than urine. Is analyzed.

Next, a method of analyzing urine using the above-mentioned biological monitoring device 100 will be described with reference to FIG.
When the gas molecules to be detected flow in the biological monitoring device 100, the gas molecules are adsorbed by the first QCM101, the second QCM102, and the third QCM103. The resonance frequencies of the first QCM 101, the second QCM 102, and the third QCM 103 are detected by the first frequency counter circuit 111, the second frequency counter circuit 112, and the third frequency counter circuit 113. From each frequency counter circuit 111 to 113, an electric signal of the detected resonance frequency is output to the information processing unit 120.

The resonance frequency of the first QCM 101, the resonance frequency of the second QCM 102, and the resonance frequency of the second QCM 102 detected by the first frequency counter circuit 111, the second frequency counter circuit 112, and the third frequency counter circuit 113 are connected to the input unit 120, respectively. The resonance frequency of QCM 103 of No. 3 and the temperature and humidity detected by the temperature / humidity sensor 130 are input.

The determination unit 122 corrects the electric signal of the resonance frequency of each QCM 101 to 103 input to the input unit 120 based on the temperature and humidity information.
Next, the determination unit 122 determines whether or not the corrected resonance frequency change of the first QCM 101 is 250 Hz or more, that is, whether or not the detection target contains water (S101). When the determination unit 122 determines No in S101, the imparting unit 123 imparts an analysis result that there is a high possibility of gas molecules other than water containing urine to the detection target, and the analysis ends.

If the determination unit 122 determines Yes in S101, the process proceeds to S102. In S102, it is determined whether or not the corrected resonance frequency change of the second QCM 102 is 100 Hz or more, that is, whether or not the detection target contains ammonia.
When the determination unit 122 determines No in S102, the imparting unit 123 imparts an analysis result that it is a gas molecule of water other than urine to the detection target, and the analysis ends.

If the determination unit 122 determines Yes in S102, the process proceeds to S103. In S103, it is determined whether or not the corrected resonance frequency change of the third QCM 103 is 100 Hz or more, that is, whether or not acetone is contained.
When the determination unit 122 determines No in S103, the analysis result indicates that the imparting unit 123 indicates that the urine gas molecule does not contain acetone and the possibility of diabetes is low, or that the blood glucose control is in an appropriate state. Is given to the detection target, and the analysis is completed.

When the determination unit 122 determines Yes in S103, the imparting unit 123 detects an analysis result that the urine gas molecule contains acetone and may be diabetic, or that the blood glucose control is not in an appropriate state. It is given to the subject and the analysis is completed.

As described above, in the present embodiment, the detection target is urine containing acetone by using the first detection element for detecting water content, the second detection element for detecting ammonia, and the third detection element for detecting acetone. It can be determined whether or not it is a gas molecule of.
If it is determined that the detection target is a gas molecule of urine containing acetone, the detection target is likely to be a gas molecule of urine of a diabetic human, and the urine is likely to contain urine sugar. Is analyzed. Based on this analysis result, it is possible to detect diabetes at an early stage, and it is possible to confirm whether or not the glycemic control of the diabetic patient is properly controlled, which can be used for physical condition management. In addition, if it is determined that the detection target is a gas molecule of urine that does not contain acetone, the user is unlikely to have diabetes, or the user who is already known to have diabetes is given glycemic control. It is analyzed that it is properly managed and can be used for physical condition management.

Further, in the present embodiment, since the health management state related to diabetes is determined by analyzing the gas molecules of urine, it is not necessary to collect urine, and it is not necessary to provide a urine collection means and a cleaning mechanism for cleaning the urine. The analysis can be easily performed.

Although the embodiments of the present invention have been described above, the present invention is not limited to the above-described embodiments, and it goes without saying that various modifications can be made.
For example, in the above-described embodiment, QCM is used as a detection element to detect gas molecules of acetone, ammonia, and water, but other ketone bodies may be detected instead of acetone.

Further, in the above-described embodiment, the analysis result is made visible by a display device provided separately from the biological monitoring device 100, and the display unit notifies the user of the analysis result by displaying an image. It is a means, but it is not limited to this.
For example, the biological monitoring device 100 may be provided with a display unit (notification unit) so that the analysis result can be displayed.

Further, as a notification means of another form of notification by the display unit, a lamp or a speaker may be provided, or the lamp may be turned on or the notification may be performed by voice from the speaker. These notification units perform notification based on the detection result given to the detection target by the granting unit 123. In addition, each notification means such as a lamp, a speaker, a display unit of a display device such as a mobile device arranged outside the biological monitoring device, and a display unit provided in the biological monitoring device may be provided independently or a plurality. It may be combined.

In the notification by lighting the lamp, for example, when urination was detected (both ammonia and water were detected) and acetone was detected, the red lamp was lit and acetone was not detected. In that case, the green lamp is set to light up. The lighting of the red lamp can be configured to warn that there is a possibility of diabetes, and the lighting of the green lamp may indicate that the possibility of diabetes is low.

In addition, in the voice notification, if urination is detected (both ammonia and water are detected) and acetone is detected, the speaker may say "There is a possibility of diabetes" or "Blood glucose." Configure the speaker to say "Your control isn't working" and if you don't detect acetone, you'll hear "You're unlikely to have diabetes" or "Your blood sugar is well controlled." be able to.

In this way, the user can confirm the analysis result of urine in real time by the display unit, the speaker, the lamp, etc. provided in the portable device or the biological monitoring device, which can be useful for early detection of diabetes and physical condition management.

As for the place where the detection element is installed, it may be installed in any place where the volatile component of urine can be detected in the toilet and the urine does not directly come into contact with the toilet seat, the lid, and the toilet bowl. It can also be installed on a wall or the like.
Further, in the above-described embodiment, the resonance frequency detected from the first QCM101 that adsorbs the moisture in the air is corrected based on the humidity detected by the temperature / humidity sensor, and is detected from the corrected resonance frequency. It was determined whether or not the subject contained water, but the present invention is not limited to this. For example, it is assumed that the change with time of the resonance frequency detected from the first QCM101 is monitored, and the time when the resonance frequency suddenly increases is the time when urine or water other than urine is put into the toilet, and this is detected. It may be determined whether or not the frequency contains water.

12 1st adsorption film 13 1st oscillator 22 2nd adsorption film 23 2nd oscillator 32 3rd adsorption film 33 3rd oscillator 100 Biometric monitoring device 101 1st detection element (1st QCM)
102 Second detection element (second QCM)
103 Third detection element (third QCM)
122 Judgment unit

Claims (11)

It is a biological monitoring device installed in a place where urine does not come in direct contact.
The first detection element that detects moisture from the detection target and
A second detection element that detects ammonia from the detection target, and
A third detection element that detects ketone bodies from the detection target,
A biological monitoring device including a determination unit for determining whether or not the detection target is urine containing a ketone body based on the detection results of the first, second, and third detection elements. The biological monitoring device according to claim 1, wherein the determination unit determines whether or not the detection target contains water based on the detection result of the first detecting element. The biological monitoring device according to claim 2.
When the determination unit determines that the detection target contains water based on the detection result of the first detection element, whether the detection target contains ammonia based on the detection result of the second detection element. A biological monitoring device that determines whether or not. The biological monitoring device according to claim 3.
When the determination unit determines that the detection target contains ammonia based on the detection result of the second detection element, the detection target contains a ketone body based on the detection result of the third detection element. A biological monitoring device that determines whether or not it is present. The biological monitoring device according to any one of claims 1 to 4.
A biological monitoring device further comprising an imparting unit that imparts an analysis result to the detection target based on the determination result by the determination unit. The biological monitoring device according to any one of claims 1 to 5.
At least one of the first detection element, the second detection element, and the third detection element is a biological monitoring device having an oscillator and an adsorption film provided on the oscillator. The biological monitoring device according to any one of claims 1 to 6 .
The first detection element, the biological monitoring apparatus having a first adsorption layer for adsorbing gas molecules of the water of polyvinyl alcohol. The biological monitoring device according to any one of claims 1 to 7 .
The second detection element is a biological monitoring device having a second adsorption film that adsorbs the gas molecules of ammonia made of an organic material having a hydroxyl group or a phosphate group as a sensitive group. The biological monitoring device according to any one of claims 6 to 8.
The third detection element adsorbs the gas molecule of the ketone body formed by using the third oscillator and the vinylidene fluoride resin and trifluoroethylene provided on the third oscillator. A biological monitoring device having 3 adsorption membranes. It is a urine analysis method using a biological monitoring device installed in a place where urine does not come into direct contact.
Moisture, ammonia and ketone bodies are detected from the detection target,
A method for analyzing urine that analyzes whether or not the detection target is urine containing ketone bodies based on the detection result. The method for analyzing urine according to claim 10.
A method for analyzing urine that analyzes that the detection target is urine containing ketone bodies and that the detection target is urine that is likely to contain urine sugar.

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