JP2018064683A - Marker for radiation imaging and method of manufacturing marker for radiation imaging - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a marker for radiation imaging that can be stuck accurately according to a shape and a range of an affected part, and is excellent in adhesion to a body surface.SOLUTION: A marker for radiation imaging made of a material containing silicone rubber or polyurethane, and a radiopaque material is a linear member having flexibility and adhesiveness. Preferably, the cross section of the linear member is of a shape in which a curved line bulging outward is an outer edge, or of a shape of a polygon.SELECTED DRAWING: Figure 1

Description

  The present invention relates to a marker used when imaging a patient with radiation and a manufacturing method thereof.

  There are known methods for imaging a patient using radiation, such as computed tomography (CT) using X-rays. In such imaging, a marker (referred to as a range designation marker, a field marker, or a line marker) attached to the patient's body surface may be used (see, for example, Patent Document 1). The marker has appropriate radiopacity and appears in a radiographic image obtained by imaging the patient. Such a marker contributes, for example, to specifying a lesion range that is difficult to specify in a radiographic image without a marker in the radiographic image. As a result, for example, it is possible to accurately specify a range in which radiation is irradiated in subsequent radiotherapy. That is, a radiotherapy plan can be appropriately made.

  As a marker sold as described above, for example, a tape-like base paper and a linear marker (narrow marker in a narrow sense) provided on the adhesive surface of the base paper and narrower than the base paper. Then, for the sake of convenience, a marker body may be referred to) and a protective paper covering the marker body is known. In using this marker, first, the protective paper is peeled off and the base paper is pasted on the body surface. Next, moisture is contained in the base paper, and the base paper is peeled off leaving the marker body. Thereby, the marker body is transferred to the body surface.

JP-A-5-78534

  Such markers cause various inconveniences. For example, since the base paper is relatively hard and the base paper is wider than the marker main body and the bending in plan view is restricted, it is difficult to apply it accurately according to the shape or range of the affected area. Or poor adhesion to the body surface. In addition, since the workability is low as described above, the burden on doctors and radiographers (users) is large, and it takes time. The patient may feel pain when removing the backing paper. There is a possibility that a so-called tape rash may occur when the base paper is affixed. Therefore, it is desirable to provide a marker and a method for manufacturing the marker that can solve at least one of the above disadvantages.

  The marker which concerns on 1 aspect of this invention consists of the material containing silicone rubber or polyurethane, and a radiopaque material, and is provided with the linear member which has flexibility and adhesiveness.

  Suitably, the shape of the cross section of the said linear member is a shape which makes the outer edge the curve which bulges outside.

  Preferably, the cross-sectional shape of the linear member is a polygon that swells outward.

  Preferably, the shape of the cross-section of the linear member has an outer edge including at least one curve and at least one straight line, and bulges outward.

  Preferably, the maximum diameter of the cross section of the linear member is 2 mm or more and 4 mm or less.

  The marker manufacturing method according to an aspect of the present invention includes a material generation step of mixing a raw material of silicone rubber or polyurethane and a radiopaque material, and a molding step of forming the material mixed in the material generation step into a linear shape. It is equipped with.

  Preferably, in the material generation step, the main agent and the curing agent are mixed at a weight ratio of 40:60 to 60:40 to form the silicone rubber, or the main agent and the curing agent are mixed at a weight ratio of 100: 40 to 100. : 60 to mix to produce the polyurethane.

  Preferably, in the forming step, the mixed material is formed into a linear shape by extrusion.

  Preferably, in the forming step, the mixed material is formed into a linear shape by curing the mixed material in a mold.

  According to said procedure or structure, a suitable marker is obtained.

FIG. 1A and FIG. 1B are external perspective views showing a marker according to an embodiment of the present invention. FIG. 2A to FIG. 2F are cross-sectional views showing various examples of cross sections of the marker. Fig.3 (a)-FIG.3 (d) are the schematic diagrams for demonstrating the manufacturing method of a marker. The schematic diagram which shows the example of the injection molding machine which manufactures a marker.

<Marker configuration>
(Outline of marker)
Fig.1 (a) and FIG.1 (b) are respectively external appearance perspective views which show the marker 1 which concerns on embodiment of this invention.

  The marker 1 is, for example, a linear (string-like) member that is integrally formed as a whole, and has flexibility and adhesiveness. The marker 1 is affixed to the patient's body surface and imaged with the patient. The imaging uses radiation such as X-rays and is performed by, for example, a CT apparatus. The marker 1 is produced as a disposable thing which is not reused, for example. However, the marker 1 may be reused. The marker 1 may be affixed to the patient's body surface as it is, or may be cut to an appropriate length by the user and affixed to the patient's body surface. From another viewpoint, the length of the marker 1 in the distribution stage may be arbitrarily set.

  In FIG. 1A, the marker 1 is wound. In FIG.1 (b), the marker 1 is linear. 1A shows the marker 1 that is wound when no or little external force is applied, and FIG. 1B shows the case where no or little external force is applied. Alternatively, it may be considered that the marker 1 is a straight line. Unlike this, FIGS. 1A and 1B are identical to each other when no or almost no external force is applied. It may be considered that the marker 1 having a shape shows a state in which it is deformed by receiving different external forces. The shape when no or little external force is applied has been mentioned, but the marker 1 generates almost no restoring force to return to a wound shape or linear shape, and no or little external force is applied. The shape of the time may not be clear.

(Marker dimensions)
The dimension of the marker 1 may be appropriately set according to the needs from the medical site. For example, the length of the marker 1 of the type assumed to be cut and used by the user in the distribution stage is 200 mm or more and 400 mm or less. Moreover, the diameter (for example, maximum diameter) of the marker 1 is 2 mm or more and 4 mm or less, for example.

  In addition, when the marker 1 is linear (string shape), the length is sufficiently larger than the diameter. For example, the length is 5 times or more or 10 times or more of the maximum diameter. On the contrary, in the present application, the term “linear” does not require any condition other than that the length is sufficiently larger than the diameter. For example, even a cylindrical shape is included in the linear shape.

(Marker characteristics)
As described above, the marker 1 has flexibility. In addition, when described in a confirming manner, the flexibility is a property capable of bending (bending) at room temperature. The normal temperature is, for example, 20 ° C. ± 15 ° C. (5 ° C. or more and 35 ° C. or less) defined by JIS (Japanese Industrial Standard). The bending of the marker 1 is realized by the viscoelasticity of the marker 1, for example. The SS curve may be appropriate. The marker 1 can be bent with a relatively large curvature, for example. For example, even if the marker 1 is bent so as to be folded 180 °, it does not completely break. Since the marker 1 is provided with flexibility, for example, the marker 1 can be in close contact with the body surface having a complicated three-dimensional shape, or can appropriately surround a lesion area having a complicated planar shape.

  Moreover, the marker 1 has adhesiveness as mentioned above. In addition, when it is described in a confirming manner, the adhesiveness is a property that adheres to the adherend when it is pressed against the subject at a normal temperature (with a relatively small pressure), and is distinguished from a property that adheres by solidification. . From another viewpoint, the surface of the marker 1 is kept in a so-called sticky state. The marker 1 can be adhered to the body surface by the adhesive force of the marker 1 itself, for example, without the need for an adhesive or volatilization of moisture by providing the adhesiveness. It is.

  Regarding the adhesiveness of the marker 1, the adhesive force (peeling force), tack (adhesiveness in a narrow sense), and cohesive force (holding force) may be set as appropriate. However, the adhesive force of the marker 1 may be made relatively small. By making the adhesive force relatively small, for example, it is possible to reduce the risk of the patient feeling pain when peeling off. In addition, the user can easily remove his / her finger from the marker 1 and workability is improved. Specifically, for example, when the adhesive force is expressed by a force (N / 10 mm) when a tape of 10 mm width attached to a stainless steel plate is folded back 180 degrees in the longitudinal direction and peeled off, the adhesion of the material of the marker 1 The force is 1 N / 10 mm or less. This size is less than the adhesive strength of the paper adhesive tape used for light packaging and the like.

  The marker 1 is given radiopacity so as to appear in the radiographic image. The impermeability may be due to radiation absorption or due to radiation reflection. The degree of radiopacity may be set as appropriate. For example, the degree of radiopacity of the marker 1 is set so that the CT value (for example, the average value of the entire volume of the marker 1) is 0 or more, 50 or more, 100 or more, or 150 or more. Further, for example, the marker 1 has a radiopacity degree set such that the CT value is 800 or less, 300 or less, or 100 or less. In addition, the lower limit value and the upper limit value of the CT value of the marker 1 may be appropriately combined as long as the lower limit value does not exceed the upper limit value. Further, the CT value of the marker 1 may be smaller than the lower limit value or larger than the upper limit value.

  Here, the CT value of water is 0, the CT value of soft tissue is about −50, the CT value of brain or liver is 35 to 100, the CT value of lung is −800 to −700, and the CT value of bone is 800 to 1000. It is. Therefore, if the degree of radiopacity of the marker 1 is equal to or greater than the above lower limit value, for example, it can sufficiently function as a marker. Further, if the degree of radiopacity of the marker 1 is equal to or less than the above upper limit value, for example, the possibility of artifacts caused by the marker 1 is reduced. The marker 1 may be a general-purpose marker that may be used in any part of the human body, and the radiopacity level may be set. Alternatively, the marker 1 may be adapted to a specific part. May be set.

(Marker material)
The material of the marker 1 contains silicone rubber or polyurethane (urethane resin) as a main component and includes a radiopaque material (for example, an X-ray opaque material). By using silicone rubber or polyurethane as a main component, for example, it becomes easy to impart appropriate elasticity and adhesiveness to the marker 1. Moreover, by including the radiopaque material in the marker 1, the radiopacity of the marker 1 can be adjusted as appropriate, and the marker 1 can be clearly reflected in the radiographic image. The main component is, for example, a component that exceeds at least 50 wt% of the material.

  The specific composition or structure of the silicone rubber may be a known appropriate one. Silicone (silicone rubber) here has a basic structure consisting of siloxane bonds in which silicon and oxygen are alternately bonded, and has not only a polymer compound (silicone in a narrow sense) with organic groups bonded, but also material properties. It shall include what is conventionally called silicone rubber obtained by mixing various materials with narrowly defined silicone rubber for adjustment and the like.

  The silicone rubber may be a liquid silicone rubber having a relatively low viscosity in the raw material stage (before curing), or may be a millable silicone rubber having a relatively high viscosity. From another viewpoint, the silicone rubber before curing may have a relatively low degree of polymerization or a molecular weight, or may have a relatively high level. The degree of polymerization of the liquid silicone rubber is, for example, 100 or more and 2,000 or less. The degree of polymerization of the millable silicone rubber is, for example, not less than 3,000 and not more than 10,000.

  The liquid silicone rubber may be a one-component type that cures by reacting with moisture in the atmosphere, or a two-component (or three-component) type that cures by mixing a curing agent with the main agent. There may be. The liquid silicone rubber may be a condensation type that generates a condensation product upon curing, or an addition type that cures by an addition reaction. The liquid silicone rubber may be a room temperature curing type that cures at room temperature, or may be a heat curing type that is cured by heating or that accelerates curing.

  In the two-component liquid silicone rubber, the specific composition or structure of the main agent containing the silicone polymer and the curing agent for crosslinking and curing the silicone polymer may be various known ones. The curing agent may be one in which the crosslinking agent and the catalyst are separated and stored until mixing with the main agent, or may be stored in a mixed state. The main agent or curing agent may contain appropriate additives such as a filler that reinforces strength, an additive that adjusts the softness of silicone rubber, or an additive that promotes or inhibits curing. As the two-component liquid silicone rubber, for example, main agent “QP1-20LSR” and curing agent “7-9600SFE” of Toray Dow Corning Co., Ltd. can be used.

  In the two-component silicone rubber, it is possible to adjust the adhesiveness and the like by appropriately setting the weight blending ratio of the main agent and the curing agent. Although depending on the specific composition and structure of the main agent and the curing agent, suitable adhesiveness can be obtained, for example, by setting the weight ratio of the main agent and the curing agent to 40:60 to 60:40. The same applies to the main agent “QP1-20LSR” and the curing agent “7-9600SFE”.

  The specific composition or structure of the polyurethane may be various known ones. The polyurethane referred to here is not only a polymer compound having a urethane bond (a narrow definition polyurethane), but also a customary product obtained by mixing various materials with a narrow definition polyurethane in order to adjust the properties of the material. In particular, what is called polyurethane (or urethane resin or urethane resin) is included.

  The polyurethane may be a one-component type that cures by reacting with oxygen or moisture in the atmosphere in the raw material stage (before curing), or a main component containing a polymer compound having a hydroxyl group (for example, a polyol). And a curing agent containing a polymeric compound having an isocyanate group (for example, polyisocyanate) may be mixed and cured. In the two-component polyurethane, the specific composition or structure of the main agent and the curing agent may be various known ones. Moreover, the main agent or the curing agent may contain a plasticizer for softening the polyurethane in a relatively large proportion (for example, a proportion larger than that of the polyol). As the polyurethane, for example, “Polycrystal PC-00N” manufactured by Polysys Co., Ltd. can be used.

  In the two-component polyurethane, it is possible to adjust the adhesiveness and the like by appropriately setting the weight blending ratio of the main agent and the curing agent. Although depending on the specific composition and structure of the main agent and the curing agent, suitable adhesiveness can be obtained, for example, by setting the weight ratio of the main agent and the curing agent to 100: 40 to 100: 60. The same applies to the above-mentioned “polycrystal PC-00N”.

  Since the radiopaque material imparts radiopacity to the marker 1 mainly composed of silicone rubber or polyurethane, it is at least more radiopaque than silicone rubber or polyurethane. Examples of such materials include barium sulfate, kaolin, bentonite, talc, aluminum silicate, magnesium silicate, silica sand, alumina, illite, vermiculite, nontronite, saponite, chlorite, allophane, calcium phosphate, iron powder. And silicon carbide, silicon nitride and zirconia. The radiopaque material is added to silicone rubber or polyurethane as a main component in an amount that does not significantly impair their flexibility (viscoelasticity) and adhesiveness. In addition, the radiopaque material may be added in an amount such that the CT value of the marker 1 is at least one of the lower limit values described above.

  The silicone rubber, polyurethane and / or radiopaque material is preferably of medical grade. That is, these materials are preferably manufactured in a factory that has received medical certification for the production process. As for the silicone rubber, a medical grade liquid silicone used as an adhesive for medical devices may be used. Moreover, it is preferable that the material of the marker 1 after mixing and the marker 1 produced using the material are also certified for medical use. The certification authority may be, for example, in the country where the marker 1 is implemented.

(Marker cross section)
The shape and dimensions of the cross section of the marker 1 are constant over the entire length of the marker 1, for example. However, the shape and / or dimensions of the cross section may not be constant over the entire length of the marker 1. For example, a flange portion whose diameter is increased in the cross section or a notch portion whose diameter is reduced in the cross section may be provided at predetermined intervals in the length direction.

  The shape of the cross section of the marker 1 (full length or most of the cross section) may be an appropriate shape. In the following, some examples will be described.

  FIG. 2A to FIG. 2F are cross-sectional views showing examples of cross sections of the marker 1. However, hatching indicating a cross section is omitted.

  FIG. 2A shows an example in which the marker 1 has a circular cross section. The diameter L1 is, for example, 2 mm or more and 4 mm or less. Thus, when the cross section is circular, for example, the flexibility and adhesive force of the marker 1 are the same in any direction of the cross section. As a result, for example, adhesion to various three-dimensional body surfaces is possible. From another viewpoint, versatility is high.

  FIG. 2B shows an example in which the cross section of the marker 1 is an ellipse. The length of the major axis length L2 (maximum diameter in another aspect) is, for example, 2 mm or more and 4 mm or less. The short axis length L3 may be set as appropriate. As described above, when the cross section is an ellipse, the marker 1 is relatively easily bent in a direction (vertical direction in the drawing) perpendicular to the long axis. Further, the marker 1 can easily secure an adhesion area in a direction orthogonal to the long axis. As a result, adhesion and / or workability are improved depending on, for example, the shape of the body surface.

  The ellipse is not necessarily an ellipse defined by mathematics, and may be any shape as long as a circle is crushed in a predetermined direction. Further, even if the shape (oval) is such that a pair of short sides of a rectangle are replaced with a pair of arcs that bulge outward, the same effect as in the case of an ellipse is achieved.

  FIG. 2C shows an example in which the cross section of the marker 1 is a semicircle. The diameter L4 (the maximum diameter from another viewpoint) is, for example, 2 mm or more and 4 mm or less. Thus, when the cross section is a semicircle, for example, the adhesion area can be increased by setting the straight line side (the lower side of the drawing) of the marker 1 to the body surface side. As a result, adhesion and / or workability are improved depending on, for example, the shape of the body surface.

  In addition, even if it is not a semicircle, as long as it is a shape formed by a straight line and a curve other than a semicircle that connects both ends of the straight line and bulges outward, the same effect as a semicircle is achieved.

  FIG. 2D shows an example in which the marker 1 has a square cross section. The length L5 of one side is, for example, 2 mm or more and 4 mm or less. The length of the diagonal (maximum diameter in another viewpoint) may be 2 mm or more and 4 mm or less. Thus, when the cross section is a square, the marker 1 is relatively easily bent in four directions. Further, the four sides of the square are easy to secure an adhesion area with respect to the body surface. As a result, adhesion and / or workability are improved depending on, for example, the shape of the body surface.

  FIG. 2E shows an example in which the cross section of the marker 1 is a rectangle other than a square. The long side length L6 is, for example, not less than 2 mm and not more than 4 mm. The length of the diagonal (maximum diameter in another viewpoint) may be 2 mm or more and 4 mm or less. Further, the short side length L7 may be set as appropriate. Thus, when the cross section is rectangular, the marker 1 is easily bent to the long side. Moreover, the long side is easy to ensure an adhesion area with respect to the body surface. As a result, adhesion and / or workability are improved depending on, for example, the shape of the body surface.

  FIG. 2 (f) is a combination of FIG. 2 (c) and FIG. 2 (e) with L4 = L6. The lengths L4 and L6 are 2 mm or more and 4 mm or less. The maximum diameter may be 2 mm or more and 4 mm or less. When the cross section has such a shape, the marker 1 is easily bent in the left-right direction on the paper surface. In addition, a straight line facing in a direction perpendicular to the paper (downward on the paper surface) can easily secure an adhesion area with respect to the body surface. As a result, adhesion and / or workability are improved depending on, for example, the shape of the body surface.

  As shown in FIGS. 2 (a) and 2 (b), when the shape of the cross section is a shape having an outer edge as a curve bulging outward (a shape having a convex closed curve in mathematics as an outer edge), for example, the marker 1 is bent. Since the stress concentration is unlikely to occur in the marker 1 when it is broken, it is difficult to break. In addition, for example, stress concentration is less likely to occur on the patient's body surface, so that the patient feels soft.

  As shown in FIG. 2D and FIG. 2E, when the cross-sectional shape is a polygon that bulges outward (convex polygon in mathematics), for example, the side has a bonding area with respect to the body surface. Easy to secure.

  Further, as shown in FIGS. 2C and 2F, the shape of the cross section has an outer edge including at least one curve and at least one straight line, and a shape that bulges outward (a shape that is convex in mathematics). For example, it is easy to ensure a bonding area with respect to a planar body surface or a body surface that bulges outward on the side, while it is bent on the outer edge of the marker 1 when it is bent. The resulting stress concentration can be relaxed by a curve.

<Marker manufacturing method>
FIG. 3A to FIG. 3D are schematic views for explaining an outline of an example of a method for manufacturing the marker 1.

  First, as shown in FIG. 3A, the material of the marker 1 is generated. Specifically, for example, two-component liquid silicone rubber or two-component polyurethane main agent 11 and curing agent 13 are mixed. Moreover, the radiopaque material 15 is added to these. Note that any two of the main agent 11, the curing agent 13, and the radiopaque material 15 may be mixed first, or three may be mixed simultaneously.

  In FIG. 3A, the case where the silicone rubber or polyurethane is two-component is taken as an example, but it may be one-component as described above. In this case, for example, when forming uncured silicone rubber or uncured polyurethane, the radiopaque material 15 may be added.

  Next, as shown in FIG. 3 (b), FIG. 3 (c) or FIG. 3 (d), the mixed material 17 in which the radiopaque material 15 is added to uncured silicone rubber or uncured polyurethane is cured. In the course of the process, the mixed material 17 is molded to produce the marker 1.

  In the example of FIG. 3B, the marker 1 is produced by extrusion molding. That is, when the mixed material 17 in the cylinder 19 is pushed out of the opening 19h of the cylinder 19 by the plunger 21, the marker 1 is formed in a linear shape having the same shape and dimensions as the opening 19h. The plunger 21 may have a screw shape.

  In the example of FIG. 3C, the marker 1 is produced by molding the mixed material 17 in the mold 25. Specifically, a groove is formed on the upper surface of the mold 25, and the marker 1 is formed by pouring the mixed material 17 into the groove. In addition, the marker 1 may be shape | molded by the die | dye not shown pressed on the type | mold 25, and the hole formed between the two type | molds.

  In the example of FIG. 3D, the marker 1 is produced by molding the mixed material 17 in the molds 29 and 31 as in FIG. 3C. However, the marker 1 is specifically molded by injection molding. That is, the mixed material 17 is extruded and filled by the plunger 33 into the hole formed between the molds 29 and 31. The plunger 33 may have a screw shape.

  FIG. 4 is a schematic diagram showing an example of the configuration of an injection molding machine 41 called LIM (Liquid Injection Molding). The marker 1 may be formed using such an injection molding machine 41.

  In the illustrated example, the injection molding machine 41 injects the mixed material 17 in the cylinder 43 into the molds 47 and 49 with the screw 45. The mixed material 17 is mixed by an apparatus in the injection molding machine 41 immediately before injection.

  The injection molding machine 41 is configured to mix the mixed material 17, for example, separately supply the main agent and the curing agent and supply them by a pump or the like, and supply the main agent and the curing agent from the supply units 51 A and 51 B. It has weighing units 53A and 53B for individually weighing, and a mixing unit 55 for mixing the main agent and the curing agent weighed by the weighing units 53A and 53B. The mixing unit 55 has, for example, a dynamic mixer (not shown) or a static mixer.

  The radiopaque material may be included in the main agent or the curing agent in the supply unit 51A or 51B, and is supplied to the mixing unit 55 by a supply unit and a metering unit (not shown) in the same manner as the main agent or the curing agent. May be.

  As described above, the marker 1 of the present embodiment is a linear member made of a material containing silicone rubber or polyurethane and a radiopaque material and having flexibility and adhesiveness.

  Therefore, for example, the marker 1 can be in intimate contact with the body surface by itself, and its adhesion is maintained. As a result, for example, the protective paper and the base paper are not necessary for the marker 1. And flexibility is not restrict | limited by a base paper, and a patient does not feel pain when peeling a base paper. Furthermore, for example, it is possible to peel off a part of the marker 1 attached to the patient and to apply it again with a slight shift in position, so that fine adjustment of the attachment position of the marker 1 is easy. That is, workability is high. Further, for example, silicone rubber and polyurethane have a low influence on the human body, and the burden on the patient is reduced. Since a radiopaque material is included, a marker can be clearly copied on a radiographic image while selecting silicone rubber or polyurethane, which is preferable in terms of flexibility and adhesiveness, as a main component.

  Moreover, in this embodiment, the maximum diameter of a cross section is 2 mm or more and 4 mm or less, for example. If the diameter is such a size, for example, the marker 1 is copied sufficiently clearly in the radiation image. Moreover, flexibility is improved by the relatively small diameter, for example. As a result, for example, it can be easily pasted on a body surface having a complicated three-dimensional shape, or pasted so as to surround a lesion area having a complicated planar shape. Further, the small diameter makes it possible to accurately indicate the boundary of the lesion range, for example.

  In addition, this invention is not limited to the above embodiment, You may implement in a various aspect.

  In the embodiment, the marker is composed of only a linear member made of a material mainly containing silicone rubber or polyurethane and containing a radiopaque material. However, a part formed of a material other than the above material may be present in a part of the longitudinal direction and / or a part of the cross section. For example, the marker may have a core wire made of another material, or may have a mark made of another material and arranged at a predetermined interval in the length direction. The marker may be covered with an appropriate paper or film before being attached to the body surface (for example, at the distribution stage).

  The shape of the cross section shown in FIGS. 2A to 2F is only a few examples. For example, in the example shown in the figure, the cross section shows only the shape that bulges outward (the shape that is convex in mathematics), but it may be a non-convex shape. For example, the marker may have a recess in the cross section by forming a spiral groove on its outer peripheral surface or by forming a groove parallel to the length direction.

  The marker manufacturing method is not limited to that exemplified in the embodiment. For example, a 3D printer may be used as appropriate, a sheet may be cut to form a linear marker, or a marker may be formed by attaching a material to the core wire.

DESCRIPTION OF SYMBOLS 1 ... Marker, 11 ... Main ingredient, 13 ... Hardener, 15 ... Radiopaque material.

Claims (9)

A radiation imaging marker comprising a linear member made of a material containing silicone rubber or polyurethane and a radiopaque material and having flexibility and adhesiveness. The radiation imaging marker according to claim 1, wherein a shape of a cross section of the linear member is a shape having an outer edge as a curved line that bulges outward. The radiation imaging marker according to claim 1, wherein a shape of a cross section of the linear member is a polygon bulging outward. The radiation imaging marker according to claim 1, wherein a shape of a cross section of the linear member has an outer edge including at least one curved line and at least one straight line, and bulges outward. The radiation imaging marker according to any one of claims 1 to 4, wherein a maximum diameter of a cross section of the linear member is 2 mm or more and 4 mm or less. A material generating step of mixing a raw material of silicone rubber or polyurethane and a radiopaque material;
A molding step of molding the material mixed in the material generation step into a linear shape;
The manufacturing method of the marker for radiation imaging provided with this. In the material generating step, the main agent and the curing agent are mixed at a weight ratio of 40:60 to 60:40 to generate the silicone rubber, or the main agent and the curing agent are mixed at a weight ratio of 100: 40 to 100: 60. The radiation imaging marker according to claim 6, wherein the polyurethane is produced. The method of manufacturing a marker for radiation imaging according to claim 6 or 7, wherein in the forming step, the mixed material is formed into a linear shape by extrusion. The method of manufacturing a marker for radiation imaging according to claim 6 or 7, wherein, in the molding step, the mixed material is cured into a linear shape by curing the mixed material in a mold.

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