JP2018063309A - Microscope device - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a microscope device allowing high magnification video to be clearly observed by simplifying a lens system of the microscope and using a 8K large screen monitor and digital zoom.SOLUTION: The microscope device comprises: a lens-barrel 110 encompassing a lens system including an object lens 112 guiding reflectance or a transmitted beam from a subject 101 to an image pickup device 131; an imaging apparatus 130 on which an image pickup device 131 receiving the reflectance or the transmitted beam to acquire a photographic image of the subject 101 is mounted; a storage part 143 storing the photographic image of the subject 101 with 8K-level resolution; an image processing part 142 enlarging and reducing the photographic image stored in the storage part 143 using digital zoom; a transmission part 134 digitally transmitting the photographic image magnification-adjusted by the image processing part 142 to a display device 150; and a display device 150 displaying in 8K-level resolution the photographic image digitally transmitted from the transmission part 134 on a large screen. An image formed from the object lens 112 to the image pickup device 131 is a real image only.SELECTED DRAWING: Figure 1

Description

  The present invention relates to a microscope apparatus. Specifically, the present invention relates to a microscope apparatus using 8K technology.

Conventional microscopes mainly have a virtual image magnified by an objective lens further magnified by an eyepiece, and the magnification of the objective lens × the magnification of the eyepiece = the magnification of the microscope. In order to eliminate image distortion due to high magnification, the lens system in the lens barrel has a complicated structure.
On the other hand, as a prior art example that receives an image of a microscope with an image sensor, a microscope that can be attached to and detached from a stand is used as a relatively large monitor screen when mounted on a stand and a microscope that can be moved away from the stand. When doing this, there is an example using a small monitor screen (see Patent Document 1). However, since it is intended to be attached to and detached from the stand, a method of forming a virtual image enlarged by the objective lens system and the zoom optical system is used, and the monitor does not use a large screen of 8K level.

JP 2010-256439 A

  However, in the 8K image technology, since the high resolution image can be enlarged / reduced by digital zoom, instead of observing with the naked eye using an eyepiece, the high resolution image is received by the image sensor and the magnification is adjusted by the digital zoom. There is no need to use a microscope. Further, the structure of the microscope, that is, the structure of the lens system in the lens barrel can be simplified. In particular, simplification is more effective in a low-magnification microscope such as an optometer.

  SUMMARY OF THE INVENTION An object of the present invention is to provide a microscope apparatus that simplifies the configuration of a lens system of a microscope and makes it possible to clearly observe a high-magnification image using an 8K large screen monitor and a digital zoom.

  In order to achieve the above object, the microscope apparatus 1 according to the first aspect of the present invention includes an objective lens 112 that guides reflected light or transmitted light from the subject 101 to the image sensor 131 as shown in FIG. A lens barrel 110 containing a lens system, a photographing device 130 equipped with an imaging element 131 that receives reflected light or transmitted light to acquire a photographed image of the subject 101, and stores a photographed image of the subject 101 with a resolution of 8K level. Storage unit 143, an image processing unit 142 that enlarges / reduces the captured image stored in the storage unit 143 using digital zoom, and a transmission unit 134 that adjusts the magnification by the image processing unit 142 and digitally transmits the captured image to the display device 150. And a display device 150 that displays a captured image digitally transmitted from the transmission unit 134 at a resolution of 8K level on a large screen. Image formed by the image pickup device 131 is a real image only.

Here, a CMOS or CCD can be used as the image sensor.
“8K level” or “equivalent to 8K” refers to the degree of resolution equivalent to a high-definition resolution image that can be realized by 8K (7680 × 4320 pixels) technology. However, in the real world, a resolution exceeding 4K resolution (3840 × 2160 pixels) may be used. Therefore, here, it is assumed that the resolution exceeds 6K resolution (specifically, the number of pixels in one frame is about 20 million or more). Since it is “8K level or higher”, a pixel number of 8K resolution (7680 × 4320 pixels) or higher may be used.

Digital zoom (electronic zoom) is to cut out a part of a photographed image and enlarge or reduce it. At 8K, high resolution can be obtained even in details, so that the sharpness does not deteriorate even if the image is enlarged or reduced. It is also possible to change the vertical and horizontal magnifications. By zooming in and zooming out, it is possible to switch between a minute region and a wide range or display them simultaneously.
The “large screen” means a monitor screen of 30 inches or more.

  With this configuration, it is possible to provide a microscope apparatus that simplifies the configuration of the lens system of the microscope and enables high-magnification images to be clearly observed using an 8K large screen monitor and digital zoom.

Further, the microscope apparatus 100 according to the second aspect of the present invention is the microscope apparatus according to the first aspect, wherein the unit area of the imaging element 131 is composed of an area of about 27 μm ² composed of three elements or four elements. Further, the lens system of the lens barrel 110 is configured so that the minimum area of the observation target of the subject is photographed in the unit region of the image sensor 131, which is an area of about 36 μm ² .

Here, as a unit area of the image sensor 131, typically, an area composed of three elements that receive R (red) G (green) B (blue), R (red) G (green) G (green). ) An area composed of four elements that receive B (blue) is included. In addition, the area | region comprised by four elements which light-receive R (red) G (green) B (blue) W (white), etc. are mentioned. If the pitch is approximately 3 microns of the image pickup device 131, the unit area is about 6 microns × 6 microns = 36 .mu.m ² at 3 × about 3 microns × 3 microns = 27 [mu] m ^2, 4 elements in 3 elements.
Further, if the minimum area of the observation target requires a resolution of 1 micron, it is necessary to take an image with 1 micron × 1 micron as the minimum area. Light from the minimum area is received by the unit area.
Further, “the lens system of the lens barrel 110 is configured” means that the magnification of the microscope is determined at the time of designing the lens system, so that the lens system in the lens barrel of the microscope is determined so as to have such a magnification. Say.
If comprised in this way, since the minimum area of an observation target will be image | photographed reliably by an image pick-up element, the picked-up image of required resolution can be acquired.

  In addition, a microscope apparatus 100A (not shown) according to the third aspect of the present invention is the microscope apparatus according to the first or second aspect, for example, as shown in FIG. For the captured image of the subject 101, the distortion related to the in-plane or focus is corrected and re-stored in the storage unit 143.

Here, there are two types of distortion correction, in-plane and focal distortion (in the direction perpendicular to the plane), but it is preferable to perform at least in-plane correction.
With this configuration, when distortion occurs in the captured image, a corrected captured image can be obtained by performing correction.

  Further, a microscope apparatus 100B (not shown) according to the fourth aspect of the present invention is a sample in which the subject 101 is mounted in the microscope apparatus according to any one of the first to fourth aspects as shown in FIG. A mounting table tilt adjustment unit 164 that can adjust the tilt of the mounting table 163 and a stereoscopic goggles 161 for observing different images between the left eye and the right eye, and the transmission unit 134 shoots by changing the tilt of the stage. When the captured image for the left eye and the captured image for the right eye are alternately transmitted to the display device 150, and when the captured image for the right eye is transmitted to the display device 150, the visual field is displayed on the left eye of the stereoscopic goggles 161. When the left-eye captured image is transmitted to the display device 150, the blocked-eye image is transmitted to the right eye of the stereoscopic goggles 161.

Here, a case where three or more photographed images are photographed by changing the inclination of the sample mounting table 163 and two of the photographed images are selected is also included in the “photographed image photographed by changing the inclination of the sample placing table 163”. Shall.
If comprised in this way, a picked-up image can be three-dimensionalized, for example using a trigonometric method using the two picked-up images imaged with changing inclination.

  A microscope apparatus 100C (not shown) according to the fifth aspect of the present invention is the microscope apparatus according to any one of the first to fourth aspects, and the control device 140 records a photographed image related to the subject 101. The display device 150 can display the captured image acquired by the control device 140 from the database on the same screen as the captured image captured by the microscope device 100C.

Here, although it differs in the field of use from the database which recorded the picked-up image relevant to the to-be-photographed object 101, the image database of a skin surface and the medical image database are mentioned, for example.
If comprised in this way, the health state and medical condition of a picked-up image can be test | inspected, referring and comparing the database image close | similar to a picked-up image, for example.

  A microscope apparatus 100D (not shown) according to the sixth aspect of the present invention is the microscope apparatus 100 according to any one of the first to fifth aspects, and the magnification by the objective lens system is 0.1 to 100. .

Here, for example, 0.1 times is used when referring to the entire image.
With this configuration, the lower the magnification, the simpler the configuration of the lens barrel 110, the smaller the size, and the smaller the distortion of the photographed image. Therefore, the lower the magnification, the greater the effect.

  ADVANTAGE OF THE INVENTION According to this invention, the microscope apparatus which simplifies the structure of the lens system of a microscope, and can observe a high magnification image clearly using an 8K large screen monitor and a digital zoom can be provided.

1 is a schematic diagram illustrating a configuration example of a microscope apparatus according to Embodiment 1. FIG. 1 is a diagram illustrating a configuration example of an illumination device of a microscope apparatus according to Embodiment 1. FIG. 1 is a diagram illustrating a configuration example of an imaging apparatus of a microscope apparatus according to Embodiment 1. FIG. 1 is a diagram illustrating a configuration example of a control device of a microscope apparatus according to Embodiment 1. FIG. FIG. 3 is a diagram for explaining a lens barrel according to the first embodiment. FIG. 3 is a diagram for explaining a large screen monitor according to the first embodiment. FIG. 6 is a diagram for explaining digital zoom according to the first embodiment. FIG. 3 is a diagram for explaining an image sensor according to the first embodiment. 10 is a diagram for explaining a microscope apparatus according to Embodiment 2. FIG. 10 is a diagram for explaining a microscope apparatus according to Embodiment 3. FIG. 10 is a diagram for explaining a microscope apparatus according to Embodiment 4. FIG.

  Embodiments of the present invention will be described below with reference to the drawings. In the drawings, the same or similar members are denoted by the same or similar reference numerals, and redundant description is omitted.

In the first embodiment, an example of a microscope apparatus that enables an image to be clearly observed using an 8K large-screen monitor and a digital zoom will be described.
FIG. 1 is a schematic diagram illustrating a configuration example of a main part of the microscope apparatus 100 according to the first embodiment.

  The microscope apparatus 100 includes a lens barrel 110, an illumination device 120, an imaging device 130, a control device 140, and a display device 150.

  The lens barrel 110 forms a real image of the subject 101 on the image sensor 131 of the imaging device 150 via the objective lens 112. Since the microscope apparatus 100 according to the present embodiment is not configured to observe the subject 101 with the naked eye via the eyepiece lens, there is no need to form a virtual image of the subject 101, and the configuration becomes simple and distortion of the photographed image. Becomes smaller. As the lens system, an objective lens 112 may be used, and a lens for correcting distortion of a captured image and a relay lens for forming an image on the image sensor 131 according to the length of the lens barrel 110 may be added. .

2A, 2 </ b> B, and 2 </ b> C are diagrams illustrating a configuration example of each unit of the microscope apparatus according to the first embodiment. 2A is a configuration example of the illumination device, FIG. 2B is a configuration example of the imaging device, and FIG. 2C is a diagram illustrating a configuration example of the control device.
Referring to FIG. 2A, lighting device 120 includes an LED (Light Emitting Diode) element 125 as a light source, and a first driver circuit 126 for driving LED element 125.
The LED element 125 includes an element that emits three colors of red (R), green (G), and blue (B) inside, and irradiates the subject 101 with white light that is a mixed color. Since the LED element 125 that can obtain a large energy is used as the light source of the illumination device 120, bright illumination light can be obtained, and thus a bright image can be obtained.
The first driver circuit 126 drives the LED element 125 according to the control of the control device 140. The dimming control of the LED element 125 is performed by PWM control or the like.

  With reference to FIG. 2B, the imaging device 130 is detachably attached to the base end of the lens barrel 110, captures an image of the subject 101 with light incident through the objective lens 112, and captures the image on the control device 140. Supply the finished image. The imaging device 130 converts an image sensor 131 that receives a captured image of the subject 101, a second driver circuit 132 that drives the image sensor 131, and the amount of light received by the image sensor 131 from analog to digital to image data. An A / D converter 133 that transmits the image data, and a transmitter 134 that transmits the digitally converted image data to the display device 150. The second driver circuit 132 sequentially reads out the pixel voltage of each pixel from the image sensor 131 and supplies it to the A / D converter 133.

  The image sensor 131 may include pixels equivalent to 8K or more. In the real world, even if the number of elements is 8K or less, a clear image can be obtained as compared with 4K. For this reason, the number of pixels of 6K or more (about 20,000 pixels or more) is equivalent to 8K.

Referring to FIG. 2C, the control device 140 includes a control unit 141, an image processing unit 142, a storage unit 143, an input / output IF (interface) 144, and an input device 145.
The control unit 141 controls the entire microscope apparatus 100 and each unit to exhibit the function as the microscope apparatus 100. The control unit 141 sequentially receives the image data transmitted from the imaging device 130 and sequentially stores the image data in the storage unit 143. The input / output IF 144 functions as an interface for data transmission / reception between the control unit 141 and an external device. The input device 145 includes a keyboard, a mouse, a button, a touch panel, and the like, and supplies a user instruction to the control unit 141 via the input / output IF 144.
The image processing unit 142 performs processing such as enlargement / reduction (magnification adjustment), noise removal, sharpening, and image conversion on the image data stored in the storage unit. Digital zoom is used to adjust the magnification of the frame data. Further, the image processing unit 142 may correct image distortion. In the second embodiment, an example in which the in-plane or focal distortion is corrected in the captured image of the subject 101 captured by the image sensor 131 and is stored in the storage unit 143 will be described.

  The storage unit 143 stores an operation program of the control unit 141, an operation program of the image processing unit 142, image data received from the transmission unit 134, frame data reproduced by the image processing unit 142, processed frame data, and the like. Since the storage unit 143 can store an image with a high 8K level resolution, that is, an image with excellent spatial resolution, a large screen monitor of, for example, 30 inches or more is used as the display device 150. It looks natural even on a large screen monitor. For this reason, all concerned parties can share large-screen images, and smooth communication can be achieved.

  Returning to FIG. 1, the display device 150 displays the image data transmitted from the control device 140 on a large screen of 8K level. In 8K, an image of the minimum size (maximum magnification) to be observed is clearly stored in the image sensor and displayed on the entire large screen, so that the image is not enlarged further, and the sharpness does not deteriorate even if the image is reduced. The display device 150 displays the image data transmitted from the control device 140 on a large screen of 8K level. At 8K, high resolution can be obtained even in details, so that the sharpness does not deteriorate even when enlarged. It is also possible to change the vertical and horizontal magnifications. By zooming in and zooming out, it is possible to switch between a minute region and a wide range or display them simultaneously.

  FIG. 3 is a diagram for explaining the lens barrel. An inverted real image 102 of the subject 101 is formed on the surface of the image sensor 131 by the action of the objective lens 112 located at the end of the lens barrel 110. That is, in such a lens system, an enlarged virtual image is temporarily created as in a general microscope, and the virtual image is not enlarged again and observed with the naked eye, but the inverted real image is displayed on the large screen monitor via the image sensor. Watch on the screen. Therefore, the configuration of the lens system in the lens barrel 110 is very simple.

FIG. 4 is a diagram for explaining a large screen monitor. The number of pixels of the 8K monitor 302 (33 million) is 16 times the number of pixels of the 2K monitor 301 (2 million). Since the number of pixels = field of view (monitor area) × pixel density, if the field of view is four times 2K, the pixel density is four times 4K. That is, it is possible to provide an image with a wider field of view and higher definition than 2K. If the image sensor has 4 pixels of R (red), G (green), G (green), and B (blue) as a unit area and a 1 μm square image is taken there, the object 101 is 3.8 mm × 2.15 mm. The area can be stored in the 8K storage element and displayed on the entire 8K screen. This can be reduced and displayed, or a part can be cut out and displayed. If the screen of the 8K storage element is clear, it is clear even if it is reduced. Note that three pixels of R (red), G (green), and B (blue) may be used as a unit region.
For example, when the magnification of the microscope is 0.1 to 100 times, if an image with a high resolution of 8K level is used as a photographed image at 100 times, 10 times, 1 time, and 0.1 times As an image, an image obtained by reducing an 8K level high-resolution image to 1/10, 1/100, or 1/1000 is used, so that it is not felt that the resolution is inferior at the time of observation.

  FIG. 5 is a diagram for explaining the digital zoom. Digital zoom is used for enlargement / reduction (magnification adjustment). In 8K, an image of the minimum size (maximum magnification) to be observed is clearly stored in the image sensor and displayed on the entire large screen, so that the image is not enlarged further, and the sharpness does not deteriorate even if the image is reduced. That is, since a clear image is stored in the storage unit 143, the image is not blurred even if the image is enlarged or reduced by the digital zoom. If the image data 401 stored in the storage unit 143 is used as it is, a large screen display of the 8K monitor 402 is obtained. It is also possible to cut out and display a part. Further, it is possible to display an image corresponding to the 4K monitor 403 and the 2K monitor 404 by reducing the image. Since the 8K compatible screen itself is clear, it is clear even if it is reduced. In this way, an image with a wide field of view can be clearly displayed. In addition, when digital zoom is used in combination with image processing (sharpening processing), a clearer image can be obtained by, for example, expressing the contrast between a characteristic part or an abnormal part and another part with emphasis.

  FIG. 6 is a diagram for explaining the image sensor 131. The image sensor 131 is formed on a semiconductor substrate using a microfabrication technique for forming an integrated circuit. A CCD circuit element or a CMOS circuit element can be used as the imaging element 131. The image sensor 131 is a so-called 8K, that is, a color image sensor having 7680 × 4320 pixels (pixels). Therefore, according to the 8K endoscope apparatus 100, a high-definition captured image can be obtained.

However, if the number of pixels of the image sensor is simply set to 8K (7680 × 4320 pixels), it is not always possible to achieve a true resolution (image density) of 8K on the display device (display) 150.
In order to realize a truly 8K resolution, it is necessary that “the pixel size is large”. If the pixel size of the image sensor is too small, the image cannot be resolved due to the light diffraction limit, resulting in a blurred image. When applied to an endoscope, because the diameter of the built-in lens of the endoscope is very small due to the restriction that it can be inserted into a body cavity, it is difficult to use a large image sensor as it is.

  In addition, it is conceivable that the diameter of the light guided through the endoscope is expanded to the full extent of the image sensor using a magnifying lens. However, the higher the magnification (the longer the focal length), the larger the image circle area on the screen, but the smaller the surgical field range to obtain reflected light. For this reason, there has been a problem that the amount of light (photons) received by the image sensor is reduced and the image becomes dark. This problem was solved by the fact that the sensitivity of the image sensor was quadrupled at 8K and the liquid crystal monitor became brighter.

  In order to achieve 8K resolution, the pixel pitch P of the image sensor 131 is set to be larger than the diffraction limit of the main light used for illumination of the subject 101. Specifically, the pitch P is set to a value larger than the reference wavelength λ corresponding to the wavelength of the illumination light emitted from the diffusion layer 122, that is, the wavelength of the light emitted from the LED element 125. When the illumination light includes light of a plurality of wavelengths, the reference wavelength λ means the light having the longest wavelength among the three primary colors constituting the illumination light, that is, the wavelength of the main component of red light. That is, it means the wavelength having the largest energy in the spectral region corresponding to red.

  Also, if the aperture (f value) of the lens system is increased, the lens system becomes brighter, but the resolution decreases. Decreasing the aperture increases the resolution but darkens. For this reason, it was found that an aperture (f value) of 10 to 16 and a pixel pitch (pixel pitch) P of 2.8 to 3.8 μm are appropriate at 8K. If the pitch is too small, interference occurs and the image is blurred. If it is too large, the substrate becomes large, which is disadvantageous in terms of volume, weight and speed. 3.0 to 3.5 μm is more suitable. When the pixel pitch P is 2.8 to 3.8 μm, the size of the image sensor 131 is about 20 to 30 mm × 12 to 18 mm.

Since there are many pixels, the color of a fine area can be recorded in one pixel. For example, at 8K, a fine thread of 20 μm can be identified. (Pixels can be seen with the naked eye at 2K, but not at 8K.)
The number of 8K pixels (about 33 million) is 16 times 2K (about 2 million). In the display device 150 (see FIG. 1), the number of pixels = field of view (monitor area) × pixel density. For example, when the field of view becomes 4 times 2K, the pixel density also becomes 4 times 2K. Assuming that the viewing angle for viewing the monitor screen is 30 degrees at 2K, 60 degrees at 4K, and 100 degrees at 8K, the realistic sensation is almost saturated at 100 degrees, so 8K is sufficient to obtain a realistic sensation.

  As described above, according to the present embodiment, it is possible to provide a microscope apparatus that simplifies the configuration of the lens system of the microscope and makes it possible to clearly observe a high-magnification image using an 8K large screen monitor and a digital zoom.

The second embodiment is an example in which distortion correction of a captured image is added to the first embodiment.
FIG. 7 is a diagram for explaining a microscope apparatus 100A (not shown) according to the second embodiment.
As for the distortion in the xy plane (in the imaging element plane), if the unit scale index (for example, 100 μm × 100 μm lattice pattern) is photographed, the magnitude and direction of the distortion of the photographed image can be understood and used for correction. Assume that the lattice prediction pattern L0 on the actual captured image of the lattice pattern becomes the lattice image pattern L1 on the actual captured image. It is assumed that the vertex P0 (x0, y0) of the lattice prediction pattern L0 and the vertex P1 (x1, y1) of the lattice image pattern L1. Deviations of the vertex P1 (x1, y1) are Δx1 = x1−x0 and Δy1 = y1−y0. If this shift is obtained for all grid points and the correspondence between the position of the predicted grid pattern L0 and the position of the grid video pattern L1 is stored, the coordinates at any point on the video can be corrected.

  Regarding the focus correction, it is said that correction can be performed from a plurality of images with different focal lengths, that is, it is possible to synthesize an image with no focal blur, and correction is possible. The chromatic aberration may be obtained by obtaining an image having a focal length for each wavelength (RGB) and combining them.

  The other configuration is the same as that of the first embodiment. As in the first embodiment, the configuration of the lens system of the microscope is simplified, and an 8K large screen monitor and a digital zoom are used to clearly display a high-magnification image. A microscope apparatus that enables observation can be provided.

In the third embodiment, a stereoscopic display 1 of a captured image will be described.
FIG. 8 is a diagram for explaining a microscope apparatus 100B (not shown) according to the third embodiment. For example, two or more photographed images photographed with different inclinations are used to separately create an image viewed from the right eye (right eye visual field) and an image viewed from the left eye (left eye visual field). The right eye field image and the left eye field image are alternately transmitted to the display device 150, and in synchronization with the transmission to the display device 150, the right eye field image is transmitted to the right eye of the stereoscopic goggles 161 of the observer. A stereoscopic image can be displayed by transmitting the left-eye visual field image to the left eye of the observer's stereoscopic goggles 161. In FIG. 8, the aspect of observing with the right eye field and the mode of observing with the right eye field by changing the inclination of the sample mounting table 163 are depicted in one figure. This shows that the samples on one sample mounting table 163 are observed by the right eye visual field and the left eye visual field by adjusting the tilt by the mounting table tilt adjusting unit 164. Reference numeral 162 denotes a lens barrel.
The other configuration is the same as that of the first embodiment. As in the first embodiment, the configuration of the lens system of the microscope is simplified, and an 8K large screen monitor and a digital zoom are used to clearly display a high-magnification image. A microscope apparatus that enables observation can be provided.

The fourth embodiment is an example in which the use of the DB data accumulated so far is added to the image display in the first embodiment.
FIG. 9 is a diagram for explaining a microscope apparatus 100C (not shown) according to the fourth embodiment.
For example, a database of skin surfaces such as skin spots, rough skin, etc. also contains a large number of people's image data, and if the same person also has time-series image data, the subject was currently photographed. Images can be compared with past data, and image data of other patients and healthy persons can be compared on the same screen. This helps to correctly determine the symptoms.

In the example of FIG. 9, the search target image data from the left, the image data searched with the first similarity, the image data searched with the second similarity, and the image searched with the third similarity Data. Further, normal image data, intermediate image data, abnormal image data (1), and abnormal image data (2) are arranged at an equal magnification from the top. By using the search image data in this way, it becomes easy to grasp the current state of the search target image data.
The other configuration is the same as that of the first embodiment. As in the first embodiment, the configuration of the lens system of the microscope is simplified, and an 8K large screen monitor and a digital zoom are used to clearly display a high-magnification image. A microscope apparatus that enables observation can be provided.

Example 5 describes an example in which the magnification of the microscope in Example 1 is low or equal. In the above embodiments, a relatively high magnification or an intermediate region is assumed. For example, in an optometry apparatus, an apparatus having a microscope function with a low magnification of about 1 to 100 times is practically used.
The microscope apparatus 100D (not shown) having the configuration according to the fifth embodiment can be applied to these low-magnification microscope apparatuses. The lower the magnification, the simpler the structure of the lens barrel 110, the smaller the size, and the smaller the distortion of the photographed image. Therefore, it can be said that it is suitable for a low magnification microscope. For example, 0.1 times is used when referring to the entire image.
The other configuration is the same as that of the first embodiment. As in the first embodiment, the configuration of the lens system of the microscope is simplified, and an 8K large screen monitor and a digital zoom are used to clearly display a high-magnification image. A microscope apparatus that enables observation can be provided.

  Although the present embodiment has been described above, the present invention is not limited to the above embodiment, and it is obvious that various modifications can be made to the embodiment without departing from the spirit of the present invention. is there.

  For example, in the above embodiment, an example of a light reflection microscope has been described, but the present invention can also be applied to a light transmission microscope. Moreover, although the above Example demonstrated the example which does not use a cooling device, you may use a cooling device. In the above embodiment, an example in which four pixels of R (red), G (green), G (green), and B (blue) are used as unit regions has been described. For example, R (red), G (green), B (blue) ) IR (near-infrared) may be added to form 4 pixels, not limited to 4 pixels. For example, R (red) G (green) B (blue) 3 pixels may be used as a unit area, and 5 pixels may be used as a unit area. If it is limited to monochrome, it may be one pixel. In the fourth embodiment, an example of using an image database of skin blemishes and rough skin has been described. However, a medical image database or a microbial image database may be used. In addition, the magnification, dimensions, and weight of the microscope, the pattern size of the image sensor, the performance of the monitor screen, and the like can be changed as appropriate.

  The present invention is applicable to a microscope apparatus.

100, 100A to 100D Microscope device 101 Subject 110 Lens barrel 112 Objective lens 120 Illumination device 125 LED element 126 First driver circuit 130 Imaging device 131 Imaging device 132 Second driver circuit 133 A / D converter 134 Transmitter 140 Control Device 141 Control Unit 142 Image Processing Unit 143 Storage Unit 144 Input / Output IF
145 Input device 150 Display device 161 Stereoscopic goggles 162 Lens barrel 163 Sample mounting table 164 Mounting table tilt adjustment unit 301 8K monitor 302 2K monitor 401 Image data 402 in storage unit 8 8K monitor 403 4K monitor 404 2K monitor

Claims (6)

A lens barrel containing a lens system including an objective lens that guides reflected light or transmitted light from the subject to the imaging device;
An imaging device equipped with the imaging element that receives the reflected light or transmitted light to acquire a captured image of the subject;
A storage unit for storing the photographed image of the subject at a resolution of 8K level;
An image processing unit that enlarges / reduces the captured image stored in the storage unit using a digital zoom;
A transmission unit for digitally transmitting a captured image whose magnification has been adjusted by the image processing unit to a display unit;
A display device that displays a captured image digitally transmitted from the transmission unit on a large screen with a resolution of 8K level;
The image formed from the objective lens to the image sensor is only a real image;
Microscope device. The unit region of the image sensor is an area of about 36 .mu.m ² comprised of regions or four elements of about 27 [mu] m ² consisting of three elements, the minimum area of the observation target of the subject, the unit region of the image sensor The lens system of the barrel is configured to be photographed
The microscope apparatus according to claim 1. The image processing unit corrects in-plane or focal distortion for the photographed image of the subject photographed by the image sensor and re-stores it in the storage unit;
The microscope apparatus according to claim 1 or 2. A mounting table tilt adjustment unit capable of adjusting the tilt of the sample mounting table on which the subject is mounted;
Stereoscopic goggles for observing different images with the left and right eyes;
The transmission unit alternately transmits a captured image for the left eye and a captured image for the right eye, which are captured while changing the tilt of the stage, to the display device, and transmits a captured image for the right eye to the display device. When transmitting, a blocking image that blocks the visual field is transmitted to the left eye of the stereoscopic goggles, and when transmitting a captured image for the left eye to the display device, the blocking eye is applied to the right eye of the stereoscopic goggles. Send visual images;
The microscope apparatus according to any one of claims 1 to 3. The control device acquires the related captured image from a database of captured images related to the subject;
The display device can display a captured image acquired from the database by the control device on the same screen as a captured image captured by the microscope device;
The microscope apparatus according to any one of claims 1 to 4. The magnification by the objective lens system is 0.1 to 100;
The microscope apparatus according to any one of claims 1 to 5.

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