JP2018050564A - Oral composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide an oral composition for deodorizing a tobacco smell that can effectively deodorize it.SOLUTION: An oral composition contains medium chain fatty acid triglyceride and menthol. The oral composition has significantly high deodorizing action on a tobacco smell and can be used for deodorizing it.SELECTED DRAWING: None

Description

  The present invention relates to oral compositions. More specifically, the present invention relates to an oral composition for deodorizing tobacco odor that can effectively deodorize tobacco odor.

  In recent years, various oral compositions for oral care containing deodorant ingredients have been developed and marketed against the background of the growing demand for oral care, particularly bad breath care. In addition, bad breath has cigarette odor, garlic odor, alcohol odor, etc. depending on the cause of the odor, and the effective deodorant component changes depending on the cause of the odor. Deodorant ingredients are selected and blended according to the cause of the target odor.

  In addition, smokers are particularly aware of the care of tobacco odors, and the development of oral compositions that have a high deodorizing effect on tobacco odors is desired. Conventionally, various studies have been made on oral care products against tobacco odor. For example, Patent Document 1 discloses that a food or drink containing, as an active ingredient, an extract of one or more kinds of plants selected from the group consisting of frankincense, mother wort, akamegashiwa, angelica, and myrtle, reduces tobacco odor. It is disclosed to obtain. Patent Document 2 discloses a tobacco odor deodorizing composition comprising a tobacco odor deodorizing composition containing a mandarin orange essential oil or a mandarin orange essential oil fraction from which terpene hydrocarbon has been substantially removed, and a carrier supporting the composition. It is disclosed that tobacco odor can be masked by blending an agent into a food or drink or oral composition.

  However, in the techniques of Patent Documents 1 and 2, there are cases in which prescriptions of oral compositions that have been diversified in recent years cannot be handled due to restrictions on prescription. Therefore, it is desired to develop a new formulation for an oral composition capable of deodorizing tobacco odor.

JP 2006-55055 A JP 2002-143285 A

  An object of the present invention is to provide an oral composition for deodorizing tobacco odor that can effectively deodorize tobacco odor.

  The present inventor has intensively studied to solve the above problems, and the oral composition containing medium-chain fatty acid triglycerides and menthol has a remarkably high deodorizing effect on tobacco odor and is used for deodorizing tobacco odor. I found out that I can do it. Furthermore, the present inventor has also found that an oral composition containing a dipeptide sweetener in addition to a medium-chain fatty acid triglyceride and menthol further improves the deodorizing action against tobacco odor. The present invention has been completed by further studies based on these findings.

That is, this invention provides the invention of the aspect hung up below.
Item 1. An oral composition for deodorizing tobacco, comprising medium-chain fatty acid triglycerides and menthol.
Item 2. The oral composition for deodorizing tobacco odor according to Item 1, further comprising a dipeptide sweetener.
Item 3. Item 3. An oral composition for deodorizing tobacco odor according to Item 1 or 2, wherein the content of the medium chain fatty acid triglyceride is 50 to 99% by weight.
Item 4. Item 4. A soft capsule comprising the oral composition according to any one of Items 1 to 3.

  The oral composition of the present invention has an excellent deodorizing effect on tobacco odor and can be used for deodorizing tobacco odor, so it is effective as an oral care product for smokers.

The oral composition of the present invention is used for deodorizing tobacco odor, and contains medium chain fatty acid triglyceride and menthol. Hereinafter, the oral composition of the present invention will be described in detail.
[Ingredients]
Medium-chain fatty acid triglyceride The oral composition of the present invention contains medium-chain fatty acid triglyceride. Medium chain fatty acid triglyceride is a compound having a structure in which three medium chain fatty acids are ester-bonded to glycerol. In the present invention, the medium chain fatty acid constituting the medium chain fatty acid triglyceride may be either a saturated fatty acid or an unsaturated fatty acid, and preferably a saturated fatty acid. Further, the medium chain fatty acid constituting the medium chain fatty acid triglyceride may have 6 to 12 carbon atoms, and specific examples include caproic acid, caprylic acid, capric acid, lauric acid and the like. From the viewpoint of further improving the deodorizing effect of tobacco odor, the carbon number is more preferably 8-12, and still more preferably 8-10.

  In the medium chain fatty acid triglyceride used in the present invention, each of the three medium chain fatty acids contained in one molecule may be the same medium chain fatty acid or a combination of two or three kinds of medium chain fatty acids. May be.

  Among medium-chain fatty acid triglycerides, from the viewpoint of further improving the deodorizing effect of tobacco odor, medium-chain fatty acid triglycerides having at least one of caprylic acid, capric acid and lauric acid are preferable, and caprylic acid or caprin A medium chain fatty acid triglyceride having at least one of acids is more preferable, and a medium chain fatty acid triglyceride having caprylic acid and capric acid is more preferable.

  The medium-chain fatty acid triglyceride having caprylic acid and capric acid is a triglyceride also referred to as tri (caprylic acid / capric acid) glyceryl, and a triester of mixed fatty acid of caprylic acid and capric acid and glycerin, or It is a mixed triglyceride of a triester of caprylic acid and glycerin and a triester of capric acid and glycerin. In the medium-chain fatty acid triglyceride having caprylic acid and capric acid, the ratio of caprylic acid and capric acid to the total weight of the constituent medium-chain fatty acids is not particularly limited. For example, caprylic acid is 30 to 98% by weight , Preferably 80 to 98% by weight, capric acid 1 to 35% by weight, preferably 1 to 20% by weight. Further, the medium chain fatty acid triglyceride having caprylic acid and capric acid may contain lauric acid as a constituent medium chain fatty acid. In the medium chain fatty acid triglyceride having caprylic acid and capric acid, when lauric acid is included as the constituent medium chain fatty acid, the ratio of lauric acid to the total weight of the constituent medium chain fatty acid is not particularly limited, but for example 0 0.1 to 21% by weight, preferably 0.1 to 1% by weight, may be mentioned, but a smaller proportion of lauric acid is desirable. Of course, lauric acid may not be contained as a constituent medium chain fatty acid.

  The content of the medium-chain fatty acid triglyceride in the oral composition of the present invention should be appropriately set according to the content of other components blended in the oral composition, the form of the oral composition, the amount of intake per time, etc. What is necessary is just 50 weight% or more, for example. More specifically, the content of the medium chain fatty acid triglyceride in the oral composition of the present invention is 50 to 99% by weight, preferably 60 to 98% by weight, more preferably 60 to 94% by weight, and still more preferably 70 to 90%. 90% by weight, particularly preferably 70 to 85% by weight.

-Menthol The oral composition of the present invention contains menthol together with medium chain fatty acid triglycerides. In this way, by using medium-chain fatty acid triglyceride and menthol together, it becomes possible to achieve a deodorizing effect that is remarkably superior to tobacco odor due to the synergistic action of both components.

  The menthol used in the present invention may be any of d-form, dl-form and l-form, and preferably includes d-form and dl-form. In the present invention, menthol may be used in the state of an essential oil containing menthol. The essential oil containing menthol can be appropriately selected from known ones, and examples thereof include mint oil and peppermint oil. In addition, the description regarding content and ratio of a menthol component in this specification is the value converted into the amount of menthol contained in the said essential oil, when using the essential oil containing a menthol.

  In the oral composition of the present invention, when menthol is contained, the content may be appropriately set according to the form of the oral composition, the amount of intake per dose, etc., for example, 1 to 30% by weight , Preferably 5 to 30% by weight, more preferably 10 to 30% by weight.

  In the oral composition of the present invention, when menthol is contained, the ratio of menthol to medium-chain fatty acid triglyceride is not particularly limited. For example, menthol is 5 to 60 parts by weight per 100 parts by weight of medium-chain fatty acid triglyceride. Is mentioned. From the viewpoint of more efficiently improving the deodorizing effect of tobacco odor, menthol is preferably 11 to 43 parts by weight, more preferably 17 to 43 parts by weight per 100 parts by weight of medium chain fatty acid triglycerides.

-Dipeptide sweetener The oral composition of this invention may contain the dipeptide sweetener in addition to the component mentioned above in order to improve the deodorizing effect of tobacco odor further. Although the dipeptide sweetener alone does not show an effective deodorizing effect of tobacco odor, the deodorizing effect of tobacco odor can be further improved by combining medium chain fatty acid triglyceride, menthol, and dipeptide sweetener.

  A dipeptide sweetener is a compound in which two amino acids are linked by a peptide bond and exhibits a sweet taste.

Although it does not restrict | limit especially about the kind of dipeptide sweetener used by this invention, For example, aspartame, advantame, etc. are mentioned. In the present invention, the dipeptide sweetener may be used alone or in combination of two or more.
Among these dipeptide sweeteners, aspartame is preferable from the viewpoint of further improving the deodorizing effect of tobacco odor.

  When the dipeptide sweetener is contained in the oral composition of the present invention, the content thereof may be appropriately set according to the form of the oral composition, the amount taken per time, etc., for example, 0.15 -5% by weight, preferably 0.5-5% by weight, more preferably 1-3% by weight.

Long chain fatty acid triglyceride The oral composition of the present invention may contain a long chain fatty acid triglyceride in order to further improve the deodorizing effect of tobacco odor. A long-chain fatty acid triglyceride alone does not show an effective deodorizing effect of tobacco odor, but the deodorizing effect of tobacco odor can be further improved by blending a long-chain fatty acid triglyceride with the above-mentioned components.

  The long-chain fatty acid triglyceride is a compound having a structure in which three long-chain fatty acids are ester-bonded to glycerol. In the present invention, the long chain fatty acid constituting the long chain fatty acid triglyceride may be either a saturated fatty acid or an unsaturated fatty acid. The long chain fatty acid constituting the long chain fatty acid triglyceride has 14 or more carbon atoms, preferably 14 to 24 carbon atoms, more preferably 16 to 22 carbon atoms, and even more preferably 16 to 218 carbon atoms. Specific examples include myristylic acid, palmitic acid, palmitoic acid, stearic acid, oleic acid, vaccenic acid, linoleic acid, linolenic acid, arachidic acid, arachidonic acid, behenic acid, lignoceric acid and the like.

  In the long-chain fatty acid triglyceride used in the present invention, the three long-chain fatty acids contained in one molecule may be the same long-chain fatty acid or a combination of two or three long-chain fatty acids. May be.

  Among long-chain fatty acid triglycerides, a long-chain fatty acid triglyceride having at least one of palmitic acid, oleic acid, and linoleic acid is preferable from the viewpoint of further improving the deodorizing effect of tobacco odor. Long chain fatty acid triglycerides having acid, oleic acid, and linoleic acid are more preferred.

  The long-chain fatty acid triglyceride having palmitic acid, oleic acid, and linoleic acid is (i) a triester of three mixed fatty acids of palmitic acid, oleic acid, and linoleic acid and glycerin, and (ii) palmitic acid. Acid, oleic acid, linoleic acid, two kinds of mixed fatty acids and triester of glycerin, and among palmitic acid, oleic acid, and linoleic acid, fatty acid and glycerin not included in the mixed fatty acid (Iii) Triester of palmitic acid and glycerin, Triester of oleic acid and glycerin, and Triglyceride of linoleic acid and glycerin.

  When the long-chain fatty acid triglyceride is contained in the oral composition of the present invention, the content thereof may be appropriately set according to the form of the oral composition, the amount taken per time, and the like. 05 to 40% by weight, preferably 0.1 to 30% by weight, more preferably 0.15 to 30% by weight.

  In the oral composition of the present invention, when the long-chain fatty acid triglyceride is contained, the ratio of the long-chain fatty acid triglyceride to the medium-chain fatty acid triglyceride is not particularly limited. The chain fatty acid triglyceride is 0.05 to 100 parts by weight, preferably 0.1 to 100 parts by weight.

-Other additive components In addition to the above-described components, the oral composition of the present invention may contain other nutritional components and pharmacological components as necessary. Such nutritional components and pharmacological components are not particularly limited as long as they can be used in foods and beverages and pharmaceuticals. For example, vitamin B1, vitamin B2, vitamin B6, vitamin B12, vitamin C, vitamin A, vitamin D Vitamins such as vitamin E, vitamin K, niacin, pantothenic acid, folic acid, biotin and lycopene; stomachic agents such as betaine hydrochloride, carnitine chloride and betanecol; minerals such as calcium, sulfur, magnesium, zinc, selenium and iron; Proteins such as soy protein, egg white powder, and whey protein; amino acids such as glycine, alanine, arginine, aspartic acid, cystine, phenylalanine, taurine, and tryptophan; fatty acids such as linoleic acid, γ-linolenic acid, and α-linolenic acid; Caramel pigment, gardenia pigment, ant Cyanine, Anato, Paprika, Safflower, Scarlet, Flavonoid, Cochineal, Amaranth, Erythrosine, Allura Red AC, New Coxin, Phloxine, Rose Bengal, Acid Red, Tartrazine, Sunset Yellow FCF, Fast Green Pigments such as FCF, brilliant blue FCF, indigo carmine; flavors such as flavors and essences of various fruits; citric acid and salts thereof, malic acid and salts thereof, tartaric acid and salts thereof, acetic acid and salts thereof, lactic acid and salts thereof, salt , Glutamic acid and salts thereof, mirin, vinegar, natural fruit juice, plant extract, fruit and sea products such as cut or powdered products; agaricus, shiitake extract, litchi, yamabushitake and other mushrooms or extracts thereof; dietary fiber , Royal jelly , Propolis, honey, chondroitin sulfate, glucosamine, ceramides, other functional materials such as hyaluronic acid. These additive components may be used alone or in combination of two or more. Moreover, about content of these additive components, it sets suitably according to the kind of additive component to be used, the form of an oral composition, etc.

  Furthermore, in order to prepare the oral composition of the present invention in a desired formulation form, a base, an additive, and the like may be included as necessary. Such bases and additives are not particularly limited as long as they can be used in foods and pharmaceuticals. For example, water, fats and oils, waxes, hydrocarbons, fatty acids, higher alcohols, esters , Water-soluble polymers, surfactants, metal soaps, lower alcohols, polyhydric alcohols, pH adjusters, buffers, antioxidants, UV inhibitors, preservatives, fragrances, powders, thickeners, dyes, Examples include chelating agents. These additive components may be used alone or in combination of two or more. Moreover, about content of these bases and additives, it sets suitably according to the kind of additive component to be used, the form of an oral composition, etc.

[Production method]
The oral composition of the present invention can be produced by mixing a medium-chain fatty acid triglyceride, menthol, and other components contained as necessary, by a known formulation method according to the formulation form.

  In addition, when a dipeptide sweetener is included in the oral composition of the present invention, since the dipeptide sweetener has low compatibility with long-chain fatty acid triglycerides, it is desirable to formulate the dipeptide sweetener in a suspended state. .

  The method for bringing the dipeptide sweetener into a suspended state is not particularly limited, and examples thereof include a method of performing stirring treatment such as mechanical stirring and ultrasonic stirring under heating conditions. The conditions during the stirring treatment are not particularly limited, but are, for example, 40 to 100 ° C, preferably 45 to 90 ° C, more preferably 60 to 90 ° C, still more preferably 70 to 90 ° C, and particularly preferably 80 to 90 ° C. Under a temperature condition of ° C., 30 to 300 minutes, preferably 40 to 300 minutes, more preferably 60 to 270 minutes can be mentioned.

[Form]
The form of the oral composition of the present invention is not particularly limited as long as it contains the above-described components and can be taken orally, and for example, it may be formulated into a soft capsule, liquid, gel or the like. Among these forms, a soft capsule is preferable.

  When the oral composition of the present invention is formulated as a soft capsule, the oral composition of the present invention may be encapsulated with a soft capsule film generally used in soft capsules.

  The soft capsule film may be any film that can form a film and contains an edible water-soluble polymer as a base. Specific examples of the base of the soft capsule film include gelatin, agar, xanthan gum, karaya gum, locust bean gum, gum arabic, pullulan, methylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, and atrium alginate. These bases may be used individually by 1 type, and may be used in combination of 2 or more type. Among these bases, gelatin is preferable.

  Although there is no restriction | limiting in particular about content of the said base in a soft capsule membrane | film | coat, For example, 40 to 90 weight%, Preferably it is 50 to 80 weight%, More preferably, 55 to 75 weight% is mentioned.

  In addition to the base, the soft capsule film may contain a plasticizer as necessary in order to promote plasticization of the base. Examples of the plasticizer include glycerin, propylene glycol, sorbitol and the like. These plasticizers may be used individually by 1 type, and may be used in combination of 2 or more type.

  When a plasticizer is contained in the soft capsule film, the content thereof may be set as appropriate according to the type of plasticizer used, etc., for example, 5 to 50% by weight, preferably 10 to 40% by weight, Preferably 20-30 weight% is mentioned.

  Furthermore, the soft capsule film may be provided with water, an emulsifier, a lower alcohol, a pH adjuster, a buffer, an antioxidant, an antiseptic, for the purpose of improving the stability of the film, seasoning, adjusting the solubility, etc. Additives such as acidulants, bitters, fragrances, powders, thickeners and chelating agents may be included. These additives may be used individually by 1 type, and may be used in combination of 2 or more type.

  The method for encapsulating the oral composition of the present invention with a soft capsule film may be any known method for producing a soft capsule, and examples thereof include a rotary soft encapsulation method and a seamless encapsulation method.

[Use / Intake]
The oral composition of the present invention is used for deodorizing tobacco odors. The timing of ingestion of the oral composition of the present invention is not particularly limited and may be before or after smoking, preferably after smoking.

  In addition, the amount of intake of the oral composition of the present invention is not particularly limited, and may be an amount that allows the intake of medium chain fatty acid triglyceride to be about 80 to 160 mg per time, for example.

  EXAMPLES The present invention will be described more specifically with reference to the following examples, but the present invention is not limited to these examples.

Test Example An oral composition having the composition shown in Table 1 (liquid except for Reference Example 2) was prepared. Specifically, for Examples 1 to 4, oral compositions were prepared by mixing predetermined amounts of the components shown in Table 1. Moreover, about the oral composition of Example 5 and 6, after mixing predetermined amounts of components other than aspartame, a predetermined amount of aspartame was further added, and a tornado stirrer (“tornado PM-202”, A suspension was formed by mechanical stirring using ASONE Co., Ltd. (rotation speed: 500 rpm) to obtain an oral composition.

  The following method evaluated the deodorizing effect with respect to the tobacco odor of the obtained oral composition. 20 μl of each oral composition was added to 180 μl of 2-methoxyphenol and mixed to obtain a mixed solution. The mixed solution was immersed in odor paper (Daiichi Pharmaceutical Co., Ltd.) cut to a length of 5 cm and allowed to permeate for 30 minutes. Then, using the odor paper impregnated with the mixed solution, the volatilization amount of 2-methoxyphenol was measured by the headspace GC / MS method. In this measurement system, when each oral composition is added, compared to the case where the oral composition is not added (control), the volatilization amount of 2-methoxyphenol is reduced. Therefore, the smaller the volatilization amount of the 2-methoxyphenol, the higher the deodorizing effect. Then, from the measured volatilization amount of 2-methoxyphenol, a volatilization amount reduction amount is calculated according to the following calculation formula (1). Further, from the volatilization amount reduction amount, the deodorizing effect is calculated according to the following calculation formula (2). The improvement rate (%) was calculated. In addition, 2-methoxyphenol is a component known to be a main odor source of tobacco odor.

  The obtained results are shown in Table 1. As a result, menthol alone did not have a deodorizing effect on tobacco odor (Comparative Example 1), but when a medium chain fatty acid triglyceride and menthol were used in combination, an excellent deodorizing effect on tobacco odor was observed (implementation) Examples 1-6). In particular, when aspartame is used in combination with both medium chain fatty acid triglycerides and menthol, the deodorizing effect of tobacco odor is further improved (Example 5), and when long chain fatty acid triglycerides are added, tobacco odor is further improved. It was confirmed that the deodorizing effect was further improved (Example 6).

Formulation Examples Oral compositions (liquid) having the compositions shown in Tables 2 and 3 were prepared in the same manner as in the above test examples. About the obtained oral composition, when the deodorizing effect with respect to tobacco odor was evaluated by the method similar to the said test example, all were confirmed that the deodorizing effect of tobacco odor is excellent.

  Moreover, about each obtained oral composition, by using the soft capsule film | membrane AG of the composition of Table 4, it encapsulates by a seamless encapsulation method, A translucent soft capsule agent (per oral composition per capsule) Product 100 mg).

Claims (4)

  An oral composition for deodorizing tobacco, comprising medium-chain fatty acid triglycerides and menthol.   The oral composition for deodorizing tobacco odor according to claim 1, further comprising a dipeptide sweetener.   The oral composition for deodorizing tobacco odor according to claim 1 or 2, wherein the content of medium chain fatty acid triglyceride is 50 to 99% by weight.   A soft capsule comprising the oral composition according to any one of claims 1 to 3.