JP2018016565A - Tanning agent - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide tanning agents having a durability to keep a color for longer days by containing a component enhancing the durability of skin coloring.SOLUTION: A tanning agent of the present invention contains a component which colors by reacting with a skin component. The component which colors by reacting with a skin component comprises dihydroxyacetone and/or erythrulose. The tanning agent of the invention further comprises a component which enhances the durability of skin coloring. The component which enhances the durability of skin coloring is selected from the group consisting of isostearyl glyceryl ether, the polysorbate 60, stearic acid PEG-150, polysorbate 20, polysorbate 80, PEG-40 hydrogenation castor oil, stearoyl glutamic-acid Na, coconut-oil-fatty-acid PEG-7 glyceryl, distearic acid PEG-150, polyoxyethylene hardened castor oil, lauric acid soles 6, myristic acid polyglyceryl 10, myristic acid polyglyceryl 5.SELECTED DRAWING: None

Description

  The present invention relates to a tanning agent.

  Conventionally, dihydroxyacetone and erythrulose have been widely used in cosmetics. In particular, in tanning agents, dihydroxyacetone and erythrulose are widely used as compounds that react with the skin components and color, and the portion applied to the skin reacts with the skin components and becomes colored (browned) to stain. Is done.

  As documents relating to a tanning agent containing dihydroxyacetone and erythrulose, for example, JP-T-2001-513780 (Patent Document 1) and JP-A-2015-028000 (Patent Document 2) are known.

  In Patent Document 1, for the artificial browning of the skin, containing erythrulose of D- or L-type or as a racemate and dihydroxyacetone as another reducing sugar having self-browning Tanning agents as active substance combinations are disclosed.

  The tanning agent described in Patent Document 1 is used as a self-browning body lotion, a self-browning white lotion, a self-browning cream or the like.

  This type of tanning agent is said to be able to reduce skin dryness and inhomogeneous peeling compared to known compositions containing dihydroxyacetone alone.

  In Patent Document 2, a copolymer or a cross-polymer containing component (A): one or more selected from acrylate and hydroxyethyl acrylate and 2-acrylamido-2-methylpropanesulfonic acid or a salt thereof as constituent units, Polyacrylamide or a mixture thereof, Component (B): Polyglycerin fatty acid ester, Component (C): Polyhydric alcohol 10-35% by mass, Component (D): Liquid oil 0.1-20% by mass, and Component ( E): Cosmetics containing a tanning agent are disclosed.

  The cosmetic described in Patent Document 2 contains dihydroxyacetone and erythrulose as the component (E), and is used as a self-tanning cosmetic (oil-in-water emulsion).

  This type of cosmetic is said to have excellent storage stability, excellent moisturizing power, and excellent tanning speed and tanning uniformity.

JP-T-2001-513780 Japanese Patent Laid-Open No. 2015-028000

  By the way, the tanning agent is usually persistent for 1 to several days. For this reason, when applying and coloring a tanning agent to skin, the colored tanning agent needs to be applied again the next day or several days later, and is complicated.

  Further, for example, when a certain shape is formed with the applied tanning agent, it is difficult to always form a certain shape every time it is applied, and problems such as drawing failure remain.

  Therefore, when it is necessary to maintain the color once formed on the skin, the tanning agent is required to have a longer durability.

  In the above-mentioned patent document 1, a change in color tone was investigated after a lotion containing erythrulose and dihydroxyacetone as another reducing sugar having self-browning was applied to the skin for about 10 days. Yes, it is possible to guarantee a certain level of sustainability by repeatedly applying to the skin. However, no consideration is given to the sufficient persistence of the coloration once applied to the skin.

  In addition, as described above, in Patent Document 2, although dihydroxyacetone and erythrulose are contained as the tanning agent of the component (E), the storage stability is excellent, the moisture retention is excellent, and the tanning speed and tanning are uniform. It is a problem to have the nature. For this reason, no consideration is given to the persistence of sufficient coloring of the tanning agent on the skin.

  Therefore, in the above Patent Documents 1 and 2, when only dihydroxyacetone and erythrulose are contained as compounds that react with skin components and color, the persistence of coloring on the skin is insufficient, and the coloring of the skin Development of a tanning agent containing a component that enhances sustainability is desired.

  Therefore, the inventors have made extensive studies in view of such a situation, and as a result, have obtained new knowledge regarding a component that enhances the sustainability of coloring on the skin (prolongs the sustaining days).

  An object of this invention is to provide the tanning agent which has the sustainability of the coloring of a longer day (extends the sustaining days) by including the component which improves the sustainability of coloring to skin.

  The tanning agent of the present invention is a tanning agent containing a component that reacts with a skin component and colors, and the component that reacts and color with the skin component contains dihydroxyacetone and / or erythrulose, In addition, an ingredient for increasing the persistence of the skin, the ingredient for enhancing the persistence of the coloring of the skin is isostearyl glyceryl ether, polysorbate 60, PEG-150 stearate, polysorbate 20, polysorbate 80, PEG-40 hydrogenated castor oil , Sodium stearoyl glutamate, coconut oil fatty acid PEG-7 glyceryl, distearate PEG-150, polyoxyethylene hydrogenated castor oil, sorbes laurate-6, polyglyceryl-10 myristate, polyglyceryl-5 myristate-5 It is characterized by that.

  According to the tanning agent having the above constitution, the components that enhance the coloration persistence of the skin are isostearyl glyceryl ether, polysorbate 60, PEG-150 stearate, polysorbate 20, polysorbate 80, PEG-40 hydrogenated castor oil, stearoyl glutamic acid Because it is selected from the group consisting of Na, palm oil fatty acid PEG-7 glyceryl, distearate PEG-150, polyoxyethylene hydrogenated castor oil, sorbes-6 laurate, polyglyceryl-10 myristate, polyglyceryl-5 myristate, skin By selecting at least one of the above-mentioned components as a component that enhances the sustainability of coloring, it is possible to have the sustainability of coloring for a longer number of days (extend the sustaining days).

  As one aspect of the present invention, the dihydroxyacetone content is preferably 1 to 20% by weight.

  According to the tanning agent of the said structure, if content of dihydroxyacetone is 1 to 20 weight%, it can have the sustainability of the coloring of a longer day (it extends a continuous day).

  In another embodiment of the present invention, the erythrulose content is preferably 1 to 20% by weight.

  According to the tanning agent of the said structure, if content of erythrulose is 1 to 20 weight%, it can have the sustainability of the coloring of a longer day (lengthening a continuous day).

  In still another embodiment of the present invention, the isostearyl glyceryl ether, polysorbate 60, PEG-150 stearate, polysorbate 20, polysorbate 80, PEG-40 hydrogenated castor oil, stearoyl glutamate Na, coconut oil fatty acid PEG-7 glyceryl, The content of PEG-150 distearate, polyoxyethylene hydrogenated castor oil, sorbes-6 laurate, polyglyceryl-10 myristate, and polyglyceryl-5 myristate is preferably 1 to 20% by weight.

  According to the above tanning agent, isostearyl glyceryl ether, polysorbate 60, PEG-150 stearate, polysorbate 20, polysorbate 80, PEG-40 hydrogenated castor oil, stearoyl glutamate Na, coconut oil fatty acid PEG-7 glyceryl, distearin If the content of acid PEG-150, polyoxyethylene hydrogenated castor oil, sorbes-6 laurate, polyglyceryl-10 myristate, polyglyceryl-5 myristate is 1 to 20% by weight, the coloration lasts longer. Be able to have sex (prolong the duration).

  As another embodiment of the present invention, it is preferable that bisethoxydiglycol cyclohexane-1,4-dicarboxylate is further included.

  According to the tanning agent having the above-described structure, since it further contains cyclohexane-1,4-dicarboxylic acid bisethoxydiglycol, it is possible to obtain good coloring and color strength and to maintain the coloration for a longer period of days. (Prolongs the duration).

  As still another embodiment of the present invention, the content of the cyclohexane-1,4-dicarboxylic acid bisethoxydiglycol is preferably 1 to 20% by weight.

  According to the tanning agent having the above structure, if the content of bisethoxydiglycol of cyclohexane-1,4-dicarboxylic acid is 1 to 20% by weight, a better initial dyeing condition (coloration and color strength) ) And can have a longer duration of coloration (extend the duration).

  As described above, according to the present invention, it is possible to provide a tanning agent that has a longer duration of coloring (longer duration) by including a component that enhances the duration of coloring on the skin. It is possible to achieve excellent effects such as.

  Hereinafter, the tanning agent according to an embodiment of the present invention will be described in detail.

  As described above, the inventors have obtained new knowledge regarding a component that enhances the persistence of coloring on the skin (prolongs the duration). The tanning agent according to this embodiment contains a component that reacts with the skin component and colors. Ingredients that react and color the skin components include dihydroxyacetone and / or erythrulose.

  In the present embodiment, dihydroxyacetone can be used without particular limitation as long as it is usually used for a tanning agent. For example, Dihydroxyacetone (manufactured by Merck & Co., Inc.) and the like are listed as commercial products.

  In the present embodiment, erythrulose can be used without particular limitation as long as it is usually used for a tanning agent. For example, ERYTHROLOSE (made by DSM Nutrition Japan Co., Ltd.) etc. are mentioned as a commercial item.

  In this embodiment, the content of dihydroxyacetone is 1 to 20% by weight. If the content of dihydroxyacetone is in the range of 1 to 20% by weight, it can have a longer duration (longer duration). When the content of dihydroxyacetone is 1% by weight or less, coloring (colorability) is poor, and when the content of dihydroxyacetone is 20% by weight or more, there is no difference in color strength. Preferably, the content of dihydroxyacetone is 5% by weight to 20% by weight.

  In this embodiment, the content of erythrulose is 1 to 20% by weight. If the content of erythrulose is in the range of 1 to 20% by weight, the coloration can be sustained for a longer number of days (the duration can be extended). When the content of erythrulose is 1% by weight or less, coloring (colorability) is poor, and when the content of erythrulose is 20% by weight or more, there is no difference in color strength. Preferably, the erythrulose content is 10% to 20% by weight.

  The tanning agent according to the present embodiment further includes a component that enhances the persistence of coloring of the skin. Ingredients that enhance the persistence of skin coloration are isostearyl glyceryl ether, polysorbate 60, PEG-150 stearate, polysorbate 20, polysorbate 80, PEG-40 hydrogenated castor oil, stearoyl glutamate Na, coconut oil fatty acid PEG-7 glyceryl PEG-150 distearate, polyoxyethylene hydrogenated castor oil, sorbes-6 laurate, polyglyceryl-10 myristate, polyglyceryl-5 myristate.

  In this embodiment, isostearyl glyceryl ether, polysorbate 60, PEG-150 stearate, polysorbate 20, polysorbate 80, PEG-40 hydrogenated castor oil, stearoyl glutamate Na, coconut oil fatty acid PEG-7 glyceryl, distearate PEG-150 , Polyoxyethylene hydrogenated castor oil, sorbes-6 laurate, polyglyceryl-10 myristate, polyglyceryl-5 myristate is used as an active agent to enhance good persistence of skin coloration and is usually used in tanning agents Any material can be used without particular limitation. For example, as a commercially available product of isostearyl glyceryl ether, Penetol GE-IS (manufactured by Kao Corporation) and the like can be mentioned.

  In this embodiment, isostearyl glyceryl ether, polysorbate 60, PEG-150 stearate, polysorbate 20, polysorbate 80, PEG-40 hydrogenated castor oil, stearoyl glutamate Na, coconut oil fatty acid PEG-7 glyceryl, distearate PEG-150 , Polyoxyethylene hydrogenated castor oil, sorbes-6 laurate, polyglyceryl-10 myristate, polyglyceryl-5 myristate is 1 to 20% by weight.

  If content of the said active agent is the range of 1 to 20 weight%, it can have the sustainability of the coloring of a longer day (lengthening a continuous day). When the content of the activator is 1% by weight or less, the effect cannot be confirmed, and when the content is 20% by weight or more, there is no significant difference in color and the like.

  Preferably, isostearyl glyceryl ether, polysorbate 60, PEG-150 stearate, polysorbate 20, polysorbate 80, PEG-40 hydrogenated castor oil, stearoyl glutamate Na, coconut oil fatty acid PEG-7 glyceryl, distearate PEG-150, poly The content of oxyethylene hydrogenated castor oil, sorbes-6 laurate, polyglyceryl-10 myristate, polyglyceryl-5 myristate is 1% by weight to 5% by weight.

  The tanning agent according to this embodiment further includes bisethoxydiglycol cyclohexane-1,4-dicarboxylate.

  In this embodiment, cyclohexane-1,4-dicarboxylic acid bisethoxydiglycol is used as a penetrant for obtaining a good initial dyeing condition, and is not particularly limited as long as it is usually used in cosmetics. Can be used. For example, Neosolue-Aquilio (made by Nippon Seika Co., Ltd.) etc. are mentioned as a commercial item.

  In this embodiment, the content of cyclohexane-1,4-dicarboxylic acid bisethoxydiglycol is 1 to 20% by weight. When the content of cyclohexane-1,4-dicarboxylic acid bisethoxydiglycol is in the range of 1 to 20% by weight, a better initial dyeing condition (coloring and color strength) can be obtained, It can have a longer duration of coloration (longer duration).

  When the content of bisethoxydiglycol of cyclohexane-1,4-dicarboxylic acid is 1% by weight or less, the effect cannot be confirmed, and when it is 20% by weight or more, there is no significant difference in color. The content of cyclohexane-1,4-dicarboxylic acid bisethoxydiglycol is preferably 1% by weight to 10% by weight.

(About other components of the present invention)
In addition to the components used in the present invention, various optional components that are generally used in cosmetics or used in tanning agents such as quasi-drugs are appropriately blended as necessary, as long as the effects of the present invention are not impaired. can do. Examples of such optional components include purified water, ethanol, oily components, humectants, thickeners, preservatives, emulsifiers, medicinal components, powders, ultraviolet absorbers, dyes, fragrances, and emulsion stabilizers. Can do.

  Next, although an Example is given and this invention is demonstrated in more detail, this invention is not limited to these.

  (Embodiment 1)

  <1. Tanning agent based on dihydroxyacetone>

<Preparation of tanning agent>
Inventors prepared the tanning agent which consists of a composition shown in the Examples 1-4 of Table 1 below. More specifically, each raw material of the composition shown in Table 1 was dissolved by stirring with a disper using a homodisper (manufactured by PRIMIX Corporation) as a device used. Using this as an evaluation sample, evaluation items were determined based on the following human use test and evaluation method. The results are also shown in Table 1 below. In addition, a compounding quantity is shown by the weight% with respect to the system by which the component is mix | blended.

(About Examples 1-4)
In Examples 1 to 4, changes in the initial dyeing condition and coloring (dyeing) persistence (duration days) depending on the content of dihydroxyacetone were examined.

  In Examples 1 to 4, the mixing amount of dihydroxyacetone was 1 wt% to 20 wt%, and the mixing amount of cyclohexane-1,4-dicarboxylic acid bisethoxydiglycol and isostearyl glyceryl ether was A tanning agent was prepared at a constant 5% by weight.

Example 1
A tanning agent was prepared with a mixing amount of dihydroxyacetone of 1% by weight.

(Example 2)
A tanning agent was prepared in the same manner as in Example 1 except that the amount of dihydroxyacetone mixed was 5% by weight.

(Example 3)
A tanning agent was prepared in the same manner as in Example 1 except that the amount of dihydroxyacetone was 10% by weight.

Example 4
A tanning agent was prepared in the same manner as in Example 1 except that the amount of dihydroxyacetone mixed was 20% by weight.

<Use test for humans>
Using the tanning agents prepared in Examples 1 to 4, a human use test was performed on three professional panelists in their 20s and 40s as evaluation targets.
<Evaluation method of evaluation items adopted in each example>

The tanning agent produced in Examples 1 to 4 was soaked into the gauze portion of the adhesive bandage and applied to each evaluation target arm. After leaving for 1 hour, the adhesive bandage was peeled off and lightly rinsed with water. From the next day, the initial dyeing condition was visually confirmed, and the sustainability of coloring (the number of days) was subjected to sensory evaluation according to the following criteria.
A: It is clearly colored.
○: Almost all colors remain.
Δ: The color is light but remains.
X: No color remains.

・ジヒドロキシアセトン：Ｄｉｈｙｄｒｏｘｙａｃｅｔｏｎｅ（メルク株式会社製）
・シクロヘキサン１，４‐ジカルボン酸ビスエトキシジグリコール：Ｎｅｏｓｏｌｕｅ‐Ａｑｕｌｉｏ（日本精化株式会社製）
・イソステアリルグリセリルエーテル：ペネトールＧＥ‐ＩＳ（花王株式会社製）
・エタノール：１級無水エタノール（日本アルコール販売株式会社製）
・ＰＧ：プロピレングリコール（旭硝子製）

・ Dihydroxyacetone: Dihydroxyacetone (Merck Co., Ltd.)
・ Cyclohexane 1,4-dicarboxylic acid bisethoxydiglycol: Neosolue-Aculio (manufactured by Nippon Seika Co., Ltd.)
Isostearyl glyceryl ether: Penetol GE-IS (manufactured by Kao Corporation)
・ Ethanol: 1st grade absolute ethanol (manufactured by Nippon Alcohol Sales Co., Ltd.)
・ PG: Propylene glycol (Asahi Glass)

  (Test results)

  From the results shown in Table 1, the initial dyeing condition was clearly colored in any case where the amount of dihydroxyacetone mixed was 1% to 20% by weight, and good results were obtained. .

  In addition, regarding the duration of coloring, when the mixing amount of dihydroxyacetone was 1% by weight, the result was good until the third day of dyeing, in which the color was clearly colored or almost remained. It was. From 5 days to 7 days after dyeing, the color remains light but it can be seen that the colorability is maintained until 7 days after dyeing.

  When the mixing amount of dihydroxyacetone was 5 wt% to 20 wt%, the initial dyeing condition was clearly colored and good results were obtained. Regarding the duration of coloring, the color was clearly colored from 1 day after dyeing to 7 days after dyeing, and the result was good. Even after 10 days from dyeing, the color remains light, and it can be seen that the colorability is maintained until 10 days after dyeing.

  (Embodiment 2)

  <Combination effect with isostearyl glyceryl ether and other active agents>

<Preparation of tanning agent>
Inventors prepared the tanning agent which consists of a composition shown in Examples 5-17 of the following Tables 2-4 similarly to Embodiment 1, and made this into an evaluation sample, and is the same as that of Embodiment 1. Evaluation items were determined based on a human use test and evaluation method. The results are shown in Tables 2 to 4 below. In addition, a compounding quantity is shown by weight% with respect to the type | system | group with which the component is mix | blended.

  (About Examples 5 to 17)

  For Examples 5 to 17, the mixing amount of dihydroxyacetone was 10% by weight, the mixing amount of cyclohexane-1,4-dicarboxylic acid bisethoxydiglycol was 5% by weight with respect to the total, and Using 12 types of active agents including stearyl glyceryl ether, the combined effect was examined.

  (Example 5)

  A tanning agent was prepared by setting the mixing amount of dihydroxyacetone to 10% by weight and the mixing amount of cyclohexane-1,4-dicarboxylic acid bisethoxydiglycol to 5% by weight.

(Example 6)
A tanning agent was prepared in the same manner as in Example 10 except that 1% by weight of isostearyl glyceryl ether was added.

(Example 7)
A tanning agent was prepared in the same manner as in Example 10 except that the amount of polysorbate 20 was changed to 1% by weight instead of isostearyl glyceryl ether.

(Example 8)
A tanning agent was prepared in the same manner as in Example 10 except that the amount of polysorbate 60 was changed to 1% by weight instead of isostearyl glyceryl ether.

Example 9
A tanning agent was prepared in the same manner as in Example 10 except that the amount of polysorbate 80 was changed to 1% by weight instead of isostearyl glyceryl ether.

(Example 10)
A tanning agent was prepared in the same manner as in Example 10 except that the amount of PEG-40 hydrogenated castor oil was changed to 1% by weight instead of isostearyl glyceryl ether.

(Example 11)
Instead of isostearyl glyceryl ether, a tanning agent was prepared in the same manner as in Example 10 except that the mixing amount of stearoyl glutamate Na was 1% by weight.

Example 12
A tanning agent was prepared in the same manner as in Example 10 except that the amount of coconut oil fatty acid PEG-7 glyceryl was changed to 1% by weight instead of isostearyl glyceryl ether.

(Example 13)
A tanning agent was prepared in the same manner as in Example 10 except that the amount of PEG-150 distearate was changed to 1% by weight instead of isostearyl glyceryl ether.

(Example 14)
A tanning agent was prepared in the same manner as in Example 10 except that the amount of PEG-150 stearate was changed to 1% by weight instead of isostearyl glyceryl ether.

(Example 15)
A tanning agent was prepared in the same manner as in Example 10 except that the amount of polyoxyethylene hydrogenated castor oil was 1% by weight instead of isostearyl glyceryl ether.

(Example 16)
A tanning agent was prepared in the same manner as in Example 10 except that the amount of polyglyceryl-10 myristate was changed to 1% by weight instead of isostearyl glyceryl ether.

(Example 17)
A tanning agent was prepared in the same manner as in Example 10 except that the amount of polyglyceryl-5 myristate was changed to 1% by weight instead of isostearyl glyceryl ether.

  (Test results)

  From the results shown in Tables 2 to 4, good results were obtained in the initial dyeing condition and the durability of coloring in any of the 12 kinds of active agents including isostearyl glyceryl ether. As for the persistence of coloring, it can be seen that in any of the above active agents, the dyeability is maintained from 1 day after dyeing to around 10 days after dyeing.

  (Embodiment 3)

  <Combination effect of cyclohexane-1,4-dicarboxylic acid bisethoxydiglycol and isostearyl glyceryl ether>

<Preparation of tanning agent>
The inventors prepared tanning agents comprising the compositions shown in Examples 18 to 20 and Comparative Examples 1 and 2 in Table 5 below, as in Embodiments 1 and 2.

  That is, a tanning agent was prepared in the same manner as in the first and second embodiments, and this was used as an evaluation sample, and evaluation items were determined based on the same use test and evaluation method for humans as in the first and second embodiments. . The results are also shown in Table 5 below. In addition, a compounding quantity is shown by weight% with respect to the type | system | group with which the component is mix | blended.

(Examples 18 to 20 and Comparative Examples 1 and 2)
In Examples 18 to 20 and Comparative Examples 1 and 2, the mixing amount of dihydroxyacetone was 10% to 20% by weight, and the mixing amount of cyclohexane-1,4-dicarboxylic acid bisethoxydiglycol and isostearyl glyceryl ether Were adjusted to 0 to 5% by weight based on the whole, respectively, to prepare tanning agents.

(Example 18)
A tanning agent was prepared by setting the mixing amount of dihydroxyacetone to 10% by weight and the mixing amount of cyclobis-1,4-dicarboxylic acid bisethoxydiglycol and isostearyl glyceryl ether to 5% by weight.

(Example 19)
A tanning agent was prepared by setting the mixing amount of dihydroxyacetone to 10% by weight and the mixing amount of isostearyl glyceryl ether to 5% by weight.

(Example 20)
A tanning agent was prepared by setting the mixing amount of dihydroxyacetone to 10% by weight and the mixing amount of cyclohexane-1,4-dicarboxylic acid bisethoxydiglycol to 5% by weight.

(Comparative Examples 1 and 2)
In Comparative Examples 1 and 2, when the mixing amount of hydroxyacetone is 10 to 20% by weight and only hydroxyacetone is mixed (Comparative Example 1), when hydroxyacetone and erythrulose are mixed (Comparative Example 2) The initial dyeing condition and the persistence of coloring were compared and examined.

(Comparative Example 1)
A tanning agent was prepared by setting the mixing amount of hydroxyacetone to 10% by weight and setting the mixing amount of cyclohexane-1,4-dicarboxylic acid bisethoxydiglycol and isostearyl glyceryl ether to 0.

(Comparative Example 2)
A tanning agent was prepared by setting the mixing amount of hydroxyacetone and erythrulose to 20% by weight and setting the mixing amount of cyclohexane-1,4-dicarboxylic acid bisethoxydiglycol and isostearyl glyceryl ether to 0, respectively.

  (Test results)

  From the results of Table 5, in Example 18, good results were obtained along with the initial dyeing condition and the duration of dyeing. More specifically, the initial dyeing condition was good in a clearly colored state. In addition, the duration of the dyeing lasted from 1 day after dyeing to 7 days after dyeing, and the color persisted, and even after 10 days from dyeing, the color remained light. Thereby, it turns out that dyeing | staining property is maintained even 10 days after dyeing | staining.

  In Example 19, the initial dyeing condition was a good result to some extent with almost the color remaining. In addition, the dyeing lasts for a period of 1 day to 3 days after the dyeing, in which the color is clearly colored and is a good result. Even after 5 days from the dyeing, the color remains almost intact, 7 days after the dyeing. Even after 10 days, the color remained light but remained. Thereby, it turns out that dyeing | staining property is maintained even 10 days after dyeing | staining.

  In Example 20, the initial dyeing condition was good in a clearly colored state. In addition, the duration of dyeing is good in a state where the color is clearly colored from 1 day after dyeing to 5 days after dyeing, and the dyeing property is maintained in a state where the color remains light even after 7 days of dyeing. I understand.

  In Comparative Examples 1 and 2, the initial dyeing condition was a good result to some extent with almost the color remaining. In addition, the dyeing lasts for a period of 1 day to 3 days after the dyeing, in which the color is clearly colored and is a good result. It was still thin. Ten days after dyeing, no color remained.

  From the above results, cyclohexane-1,4-dicarboxylic acid bisethoxydiglycol improves the initial dyeing condition, and isostearyl glyceryl ether extends the color persistence (duration days). I understand.

  (Embodiment 4)

  <Combination effect with cyclohexane-1,4-dicarboxylic acid bisethoxydiglycol and other penetrants>

<Preparation of tanning agent>
Inventors prepared the tanning agent which consists of a composition shown in Example 21 of the following Table 6, and Comparative Examples 3-6 similarly to the said Embodiments 1-3, and made this into an evaluation sample, and said implementation The evaluation items were determined based on the same human use test and evaluation method as in Embodiments 1 to 3. The results are shown in Table 6 below. In addition, a compounding quantity is shown by weight% with respect to the type | system | group with which the component is mix | blended.

(About Example 21 and Comparative Examples 3-6)
For Example 21 and Comparative Examples 3 to 6, the mixing amount of dihydroxyacetone was 10% by weight, and the mixing amount of cyclohexane-1,4-dicarboxylic acid bisethoxydiglycol and the other penetrant was 5% by weight. As a preparation, a tanning agent was prepared.

(Example 21)
A tanning agent was prepared by setting the mixing amount of dihydroxyacetone to 10% by weight and the mixing amount of cyclohexane-1,4-dicarboxylic acid bisethoxydiglycol to 5% by weight.

(Comparative Example 3)
A tanning agent was prepared by setting the mixing amount of dihydroxyacetone to 10% by weight and replacing the cyclohexane-1,4-dicarboxylic acid bisethoxydiglycol with a mixing amount of ethoxydiglycol of 5% by weight.

(Comparative Example 4)
A tanning agent was prepared by setting the mixing amount of dihydroxyacetone to 10% by weight and replacing the cyclohexane-1,4-dicarboxylic acid bisethoxydiglycol with a mixing amount of chitosan of 5% by weight.

(Comparative Example 5)
The mixing amount of dihydroxyacetone is 10% by weight, and instead of cyclohexane-1,4-dicarboxylic acid bisethoxydiglycol, the mixing amount of EG / PPG / polybutylene glycol-8 / 5/3 glycerin is 5% by weight. As a preparation, a tanning agent was prepared.

(Comparative Example 6)
A tanning agent was prepared by setting the mixing amount of dihydroxyacetone to 10% by weight and replacing the cyclohexane-1,4-dicarboxylic acid bisethoxydiglycol with a mixing amount of PCA-Na to 5% by weight.

・キトサン：Ｌｉｐｉｄｕｒｅ‐ＰＭＢ（Ｐｈ‐１０）（日本油脂製）
・ＥＧ／ＰＰＧ／ポリブチレングリコール−８／５／３／グリセリン：ウィルブライドＳ‐７５３(日本油脂製)
・ＰＣＡ‐Ｎａ：ｄｌ‐ピロリドンカルボン酸ナトリウム液（５０％）(味の素株式会社製)

-Chitosan: Lipidure-PMB (Ph-10) (manufactured by NOF Corporation)
EG / PPG / polybutylene glycol-8 / 5/3 / glycerin: Willbride S-753 (manufactured by NOF Corporation)
PCA-Na: dl-pyrrolidonecarboxylate sodium solution (50%) (Ajinomoto Co., Inc.)

  (Test results)

  From the results shown in Table 6, in Example 21, the initial dyeing condition was better in the state of being clearly colored as compared with Comparative Examples 3-6. Further, the duration of staining continued from 1 day after staining to 5 days after staining, and the color persisted, and even after 7 days, the color remained light. Thereby, it turns out that dyeing | staining property is maintained even 7 days after dyeing.

  In Comparative Examples 3 to 6, the initial dyeing condition was relatively good with almost the color remaining. In addition, the duration of the dyeing lasted from 1 day after dyeing to 3 days after dyeing, and the color persisted, and after that, the color remained light until 5 to 7 days after dyeing.

  From the above results, it can be said that cyclohexane-1,4-dicarboxylic acid bisethoxydiglycol is the best and the most suitable as a penetrant.

  (Embodiment 5)

  <2. Tanning agent based on erythrulose>

<Preparation of tanning agent>
The inventors prepared tanning agents comprising the compositions shown in Examples 22 and 23 of Table 7 below. More specifically, each raw material of the composition shown in Table 7 was dissolved by stirring with a disper using a homodisper (manufactured by PRIMIX Corporation) as a device used. Using this as an evaluation sample, evaluation items were determined based on the same human use test and evaluation method as in the first to fourth embodiments. The results are also shown in Table 7 below. In addition, a compounding quantity is shown by weight% with respect to the type | system | group with which the component is mix | blended.

(Examples 22 and 23)
In Examples 22 and 23, changes in the initial dyeing condition and the coloration (dyeing) persistence (duration days) depending on the erythrulose content were examined.

  In Examples 22 and 23, the mixing amount of erythrulose was 10% by weight to 20% by weight, and the mixing amount of cyclohexane-1,4-dicarboxylic acid bisethoxydiglycol and isostearyl glyceryl ether was A tanning agent was prepared at a constant 5% by weight.

(Example 22)
A tanning agent was prepared by setting the amount of erythrulose to 10% by weight.

(Example 23)
A tanning agent was prepared in the same manner as in Example 23 except that the amount of erythrulose was 20% by weight.

  (Test results)

  From the results of Table 7, in Examples 22 and 23, the same good results were obtained in the initial dyeing condition and the color persistence. That is, the initial dyeing condition was good with a clear color. Further, the color persistence was a state in which the color was clearly colored after 1 day of dyeing, and a state in which the color remained almost light or the color remained light after 3 to 7 days from dyeing. Thereby, it turns out that dyeing | staining property is maintained even 7 days after dyeing.

  (Embodiment 6)

  <Combination effect with isostearyl glyceryl ether and other active agents>

<Preparation of tanning agent>
The inventors prepared a tanning agent composed of the composition shown in Comparative Example 8 and Examples 24-26 in Table 8 below, and used this as an evaluation sample. Based on the evaluation method, evaluation items were determined. The results are also shown in Table 8 below. In addition, a compounding quantity is shown by weight% with respect to the type | system | group with which the component is mix | blended.

(Comparative Example 8 and Examples 24-26)
In Comparative Example 8 and Examples 24-26, the mixing amount of erythrulose is 10% by weight, and the mixing amount of cyclohexane-1,4-dicarboxylic acid bisethoxydiglycol is 5% by weight with respect to the whole. Using four kinds of activators including isostearyl glyceryl ether as activators, the combined effect was examined.

(Comparative Example 8)
A tanning agent was prepared by setting the mixing amount of erythrulose to 10% by weight and the mixing amount of cyclohexane-1,4-dicarboxylic acid bisethoxydiglycol to 5% by weight.

(Example 24)
A tanning agent was prepared in the same manner as in Comparative Example 8 except that 1% by weight of PEG-150 stearate was added.

(Example 25)
A tanning agent was prepared in the same manner as in Comparative Example 8 except that 1% by weight of polysorbate 20 was added.

(Example 26)
A tanning agent was prepared in the same manner as in Comparative Example 8, except that 1% by weight of coconut oil fatty acid PEG-7 glyceryl was added.

  (Test results)

  From the results shown in Table 8, in Comparative Example 8, the initial dyeing condition was a good result with a clear coloration. However, although the color persists from 1 day after dyeing to 3 days after dyeing, the color persists, but no color remains after 5 days after dyeing.

  In Example 24, the initial dyeing condition was a good result with a clear coloration. Further, the color persistence is a state in which the color remains almost from 1 day after dyeing to 5 days after dyeing, or the color remains light, and the duration of coloration is further extended as compared with Comparative Example 8. .

  In Example 25 and Example 26, the initial dyeing condition was a good result in a clearly colored state. In addition, the color persistence is a state in which the color remains almost from 1 day after dyeing to 7 days after dyeing, or the color remains light, and the duration of coloring is further extended as compared with Comparative Example 8. It was.

  From the above results, in any of the three types of active agents, significantly better results were obtained as compared with Comparative Example 8 in the sustainability of coloring (the number of days).

  (Embodiment 7)

  <Combination effects with isostearyl glyceryl ether and cyclohexane-1,4-dicarboxylic acid bisethoxydiglycol>

  The inventors prepared tanning agents comprising the compositions shown in Examples 27 to 29 and Comparative Example 7 in Table 9 below, and used this as an evaluation sample for humans as in the above Embodiments 1 to 6. Based on the test and the evaluation method, the evaluation items were determined. The results are shown in Table 9 below. In addition, a compounding quantity is shown by weight% with respect to the type | system | group with which the component is mix | blended.

(Examples 27 to 29 and Comparative Example 7)
In Examples 27 to 29 and Comparative Example 7, the mixing amount of erythrulose was 10% by weight and the mixing amount of cyclohexane-1,4-dicarboxylic acid bisethoxydiglycol and / or isostearyl glyceryl ether was The tanning agent was prepared at a constant 5% by weight with respect to the whole.

(Example 27)
A tanning agent was prepared by setting the mixing amount of erythrulose to 10% by weight and the mixing amount of cyclohexane-1,4-dicarboxylic acid bisethoxydiglycol to 5% by weight.

(Example 28)
A tanning agent was prepared by setting the mixing amount of erythrulose to 10% by weight and the mixing amount of isostearyl glyceryl ether to 5% by weight.

(Example 29)
A tanning agent was prepared by setting the mixing amount of erythrulose to 10% by weight, the mixing amount of cyclohexane-1,4-dicarboxylic acid bisethoxydiglycol and isostearyl glyceryl ether to 5% by weight, respectively.

(Comparative Example 7)
A tanning agent was prepared by setting the amount of erythrulose to 10% by weight.

  (Test results)

  From the results of Table 9, compared with Comparative Example 7, in Example 27, the initial dyeing condition was a good result in a clearly colored state. Further, the color persistence was a state in which the color remained almost from 1 day after dyeing to 3 days after dyeing, and the duration was good compared with Comparative Example 7.

  Compared with Comparative Example 7, in Example 28, the initial dyeing condition was a good result in a state where the color was clearly colored. Further, the color persistence was a state in which the color remained almost from 1 day after dyeing to 7 days after dyeing, or the color remained light, and the duration was even better than in Example 25.

  Compared to Comparative Example 7, in Example 29, the initial dyeing condition was a good result with a clear coloration. Further, the color persistence was a good result in a state where the color was clearly colored one day after dyeing. From 2 days after dyeing to 7 days after dyeing, almost the color remained or the color remained light, and the duration was even better as in Example 26.

  Based on the above results, the initial dyeing condition is further improved with bisethoxydiglycol cyclohexane-1,4-dicarboxylate, and the color persistence (duration days) is extended with isostearyl glyceryl ether. I understand.

  As described above, according to the tanning agent according to the present embodiment, by selecting at least one of the above components as a component that enhances the persistence of coloring on the skin, it has a sustainability of coloring for a longer number of days ( Can extend the duration).

  In addition, when the content of dihydroxyacetone is 1 to 20% by weight, it is possible to obtain a good initial dyeing condition (coloring and color strength) and to have a longer-lasting coloration duration. (Extend the duration).

  In addition, when the content of erythrulose is 1 to 20% by weight, it is possible to obtain a good initial dyeing condition (coloring and color strength) and to have a long-lasting coloring duration. (Extend the duration).

  In addition, as a component (active agent) for enhancing the persistence of coloring on the skin, isostearyl glyceryl ether, polysorbate 60, PEG-150 stearate, polysorbate 20, polysorbate 80, PEG-40 hydrogenated castor oil, stearoyl glutamate Na, The content of coconut oil fatty acid PEG-7 glyceryl, distearate PEG-150, polyoxyethylene hydrogenated castor oil, sorbes-6 laurate, polyglyceryl-10 myristate, polyglyceryl-5 myristate is 1 to 20% by weight For example, it is possible to obtain good coloring and color strength and to have a longer duration of coloring (longer duration).

  In addition, as a penetrant for obtaining a good initial dyeing condition, bisethoxydiglycol cyclohexane-1,4-dicarboxylate is further included, so that even better coloring and color strength can be obtained. , It can have a longer duration of coloration (extend the duration).

  In addition, if the content of bisethoxydiglycol of cyclohexane-1,4-dicarboxylic acid is 1 to 20% by weight, a better initial dyeing condition (coloring and color strength) can be obtained. , It can have a longer duration of coloration (extend the duration).

  In addition, the tanning agent of this invention is not limited to the said embodiment, Of course, it can change suitably in the range which does not deviate from the summary of this invention.

  In the above embodiment, chitosan: Lipidure-PMB (Ph-10) (manufactured by NOF), EG / PPG / polybutylene glycol-8 / 5/3 / glycerin: Wilbride S-753 (manufactured by NOF), PCA- Na: dl-pyrrolidone carboxylate solution (50%) (Ajinomoto Co., Inc.) Ethanol: 1st grade absolute ethanol (Nihon Alcohol Sales Co., Ltd.) and PG: Propylene glycol (Asahi Glass Co., Ltd.) are used. It is not limited to these.

  In the above embodiment, the components that enhance the persistence of skin coloration are isostearyl glyceryl ether, polysorbate 60, stearic acid PEG-150, polysorbate 20, polysorbate 80, PEG-40 hydrogenated castor oil, stearoyl glutamate Na, coconut oil Fatty acid PEG-7 glyceryl, distearate PEG-150, polyoxyethylene hydrogenated castor oil, polyglyceryl-10 myristate, polyglyceryl-5 myristate, which increases the persistence of coloring on the skin (prolongs the duration) If it is a thing, it will not be limited to these, For example, lauric acid sorbes-6 etc. may be used.

  In the above embodiment, the tanning agent prepared in each embodiment is soaked in the gauze part of the adhesive bandage and applied to each evaluation target arm, and from the next day, the initial dyeing condition is visually confirmed, and the coloring Although sensory evaluation of the sustainability (the number of days of sustaining) was performed based on the above criteria, the present invention is not limited to this. For example, the tanning agent prepared in each embodiment is applied to the eyebrow area or the like of each evaluation target, and the initial dyeing condition and the sustainability of coloring (the number of days of maintenance) are subjected to sensory evaluation based on the above criteria. Good.

  The form of the tanning agent of the present invention is not particularly limited, and various forms employed in general tanning agents and the like can be employed as long as the effects of the present invention are not impaired.

  In addition, the tanning agent of the present invention can be applied in various fields such as pharmaceuticals, quasi drugs, and cosmetics.

  The tanning agent of the present invention is effectively used for a tanning agent that can have outstanding coloring on the skin and a longer-lasting duration.

Claims (6)

A tanning agent containing a component that reacts with a skin component and colors.
Ingredients that react with the skin components and color include dihydroxyacetone and / or erythrulose,
An ingredient that further enhances the persistence of skin coloring,
Ingredients that increase the persistence of the coloring of the skin are isostearyl glyceryl ether, polysorbate 60, PEG-150 stearate, polysorbate 20, polysorbate 80, PEG-40 hydrogenated castor oil, stearoyl glutamate Na, coconut oil fatty acid PEG-7 A tanning agent selected from the group consisting of glyceryl, PEG-150 distearate, polyoxyethylene hydrogenated castor oil, sorbes-6 laurate, polyglyceryl-10 myristate, polyglyceryl-5 myristate.   The tanning agent according to claim 1, wherein a content of the dihydroxyacetone is 1 to 20% by weight.   The tanning agent according to claim 1 or 2, wherein the erythrulose content is 1 to 20% by weight.   Isostearyl glyceryl ether, polysorbate 60, PEG-150 stearate, polysorbate 20, polysorbate 80, PEG-40 hydrogenated castor oil, stearoyl glutamate Na, coconut oil fatty acid PEG-7 glyceryl, distearate PEG-150, polyoxyethylene Tanning agent in any one of Claims 1-3 whose content of hydrogenated castor oil, sorbes-6 laurate, polyglyceryl-10 myristate, and polyglyceryl-5 myristate is 1 to 20 weight%.   The tanning agent according to any one of claims 1 to 4, further comprising cyclohexane-1,4-dicarboxylic acid bisethoxydiglycol.   The tanning agent according to claim 5, wherein the content of the cyclohexane-1,4-dicarboxylic acid bisethoxydiglycol is 1 to 20% by weight.