JP2018002685A - Emulsion composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide an emulsion composition having excellent emulsion stability.SOLUTION: Blending polyethylene sodium sulfonate in an emulsion composition improves the emulsion stability.SELECTED DRAWING: None

Description

  The present invention relates to an emulsified composition. More specifically, the present invention relates to an emulsion composition having excellent emulsion stability.

  The emulsified composition can be formulated with an aqueous component and an oily component, can be used for various pharmaceutical formulations, and has an excellent usability when applied to the skin. Therefore, it is widely used in the field of external medicine and cosmetics. However, when the emulsified composition is stored for a long period of time, the oil phase and the aqueous phase are liable to be separated, which is disadvantageous in terms of emulsion stability.

  Moreover, the cream which consists of a highly viscous emulsified composition is widely accepted by consumers from points, such as a favorable usability | use_condition and the difficulty of dripping at the time of use. Conventionally, in order to produce a highly viscous emulsion composition, it has been necessary to blend a higher amount of a higher alcohol or a large amount of a thickener. However, in such an emulsified composition having a higher viscosity by adding a higher alcohol or a thickener, an improvement in the emulsification stability is recognized due to the improved viscosity, but an emulsification stabilization by simply increasing the viscosity Is limited and still cannot be said to have satisfactory emulsion stability. Furthermore, the addition of a large amount of thickener causes the emulsion composition to become sticky, resulting in a decrease in the feeling of use.

  Conventionally, an O / W emulsification is carried out by emulsifying a nonionic surfactant, a linear higher alcohol having 16 or more carbon atoms, and an oil phase containing oil and an aqueous phase containing water at a temperature of 70 ° C. or higher. The emulsion is cooled by stirring the O / W emulsion and stirring is stopped at a temperature higher than the peak temperature in the temperature range where the oil phase forms α-gel in the aqueous phase and lower than 70 ° C. It is known that a high-viscosity O / W cream having stability can be obtained (see Patent Document 1). However, in the technique of Patent Document 1, the operation after the emulsification step is complicated, and there is a drawback in terms of manufacturing simplicity.

  Against the background of such conventional technology, there has been a demand for the development of a formulation technology that provides excellent emulsification stability by a simple method.

JP 2011-72310 A

  An object of the present invention is to provide an emulsion composition having excellent emulsion stability.

  The present inventor conducted intensive studies to solve the above problems, and found that the emulsion stability was improved by blending sodium polyethylene sulfonate with the emulsion composition. In addition, in the case of a water-in-oil emulsion composition, it has been found that when sodium polyethylene sulfonate is added, the emulsion stability is improved and the viscosity is increased. Furthermore, by blending sodium polyethylene sulfonate and benzyl nicotinate into a water-in-oil emulsion composition, in addition to improving the emulsion stability and viscosity, it is possible to exhibit a markedly excellent blood circulation promoting action. I found it. The present invention has been completed by further studies based on these findings.

That is, this invention provides the invention of the aspect hung up below.
Item 1. An emulsified composition containing sodium polyethylene sulfonate.
Item 2. Item 2. The emulsion composition according to Item 1, comprising at least one oily component selected from the group consisting of benzyl nicotinate, γ-oryzanol, retinol, a derivative of retinol, tocopherol, and a derivative of tocopherol.
Item 3. Item 3. The emulsified composition according to Item 1 or 2, comprising liquid oil.
Item 4. Item 4. The emulsified composition according to any one of Items 1 to 3, which does not contain solid oil.
Item 5. Item 5. The emulsified composition according to any one of Items 1 to 4, which is a water-in-oil type.
Item 6. An emulsion stabilizer comprising sodium polyethylene sulfonate.
Item 7. An emulsification stabilization method comprising adding sodium polyethylene sulfonate to an emulsified composition.

  The emulsified composition of the present invention can have excellent emulsification stability regardless of whether it is a water-in-oil type or an oil-in-water type. Moreover, when the emulsion composition of this invention is a water-in-oil type, since the improvement of a viscosity is also recognized, it can also be used as a high-viscosity type external preparation which has moderate hardness. Furthermore, in a preferred embodiment of the emulsified composition of the present invention, it can also exhibit a blood circulation promoting action that is remarkably excellent, so it is used for the purpose of maintaining or recovering a healthy skin state, anti-aging of the skin, etc. Can do.

1. Emulsified Composition The emulsified composition of the present invention is characterized by containing sodium polyethylene sulfonate. Hereinafter, the emulsified composition of the present invention will be described in detail.

Sodium polyethylene sulfonate The emulsion composition of the present invention contains sodium polyethylene sulfonate as a component for improving the emulsion stability.

Polyethylene sulfonate sodium is sometimes referred to as aporate sodium, and is a polymer compound obtained by radical polymerization of a monomer represented by the following formula. Polyethylene sulfonate sodium is also a compound known as CAS registration number “25053-27-4”.

  Although it does not restrict | limit especially about the viscosity characteristic of the sodium polyethylenesulfonate used by this invention, The intrinsic viscosity in 25 degreeC is 0.06-0.08 ml / g as a suitable example. Here, the intrinsic viscosity at 25 ° C. is a value measured according to the method described in the “Viscosity” column of the “Sodium Polyethylenesulfonate” section of the Japanese Pharmacopoeia Standards for Drugs.

  The sodium polyethylene sulfonate used in the present invention is not particularly limited as long as it is usually used in cosmetics, external medicines, etc., but those listed in the Japanese Pharmacopoeia Pharmaceutical Standards. Is preferred.

  The content of sodium polyethylene sulfonate in the emulsion composition of the present invention may be appropriately set according to the emulsion type, form, use, etc. of the emulsion composition, for example, 0.01 to 10% by weight, preferably 0.1 to 5 weight% is mentioned. From the viewpoint of improving the emulsion stability more effectively, improving the viscosity more effectively in the case of a water-in-oil type, or further improving the blood circulation promoting action when containing benzyl nicotinate, The content of sodium polyethylene sulfonate in the emulsion composition of the present invention is more preferably 0.1 to 3% by weight, particularly preferably 0.1 to 2% by weight, and most preferably 0.5 to 1.5% by weight. Is mentioned.

Benzyl nicotinate, γ-oryzanol, retinol, derivatives of retinol, tocopherol, and / or derivatives of tocopherol The emulsified composition of the present invention comprises benzyl nicotinate, γ-oryzanol, retinol, derivatives of retinol, tocopherol, and tocopherol derivatives. It may contain at least one oily component selected from the group consisting of: These oily components tend to reduce the emulsion stability or the viscosity in the conventional emulsion composition, but according to the emulsion composition of the present invention, these oily components are contained. However, the emulsification stability is improved, and in particular, in the case of a water-in-oil type, a decrease in viscosity can be suppressed.

(Benzyl nicotinate)
Benzyl nicotinate is a known compound known to have a blood circulation promoting action, a cell activation action, and the like. When the emulsified composition of the present invention contains benzyl nicotinate, it can exert a blood circulation promoting action. Particularly, when the emulsion composition contains benzyl nicotinate and is a water-in-oil type, the blood circulation promotion is remarkably excellent. It becomes possible to exert the effect.

  When benzyl nicotinate is contained in the emulsified composition of the present invention, the content is not particularly limited, but is, for example, 0.01 to 10% by weight, preferably 0.05 to 5% by weight, and more preferably. Is 0.1 to 5% by weight.

  Further, when benzyl nicotinate is contained in the emulsified composition of the present invention, the ratio of sodium polyethylene sulfonate and benzyl nicotinate is not particularly limited, and may be appropriately set within a range satisfying the content of each component described above. For example, benzyl nicotinate is 0.1 to 100 parts by weight, preferably 0.1 to 30 parts by weight, and more preferably 0.5 to 15 parts by weight per 100 parts by weight of sodium polyethylene sulfonate.

(Γ-oryzanol)
γ-Oryzanol is an ester of ferulic acid and triterpene alcohol or an ester of ferulic acid and sterol.

In the emulsified composition of the present invention, as γ-oryzanol, either an ester of ferulic acid and triterpene alcohol or an ester of ferulic acid and sterol may be used alone, or these may be used in combination. Also good. Preferred examples of γ-oryzanol used in the present invention include those containing cycloartenyl ferulate (C ₄₀ H ₅₈ O ₄ ), more preferably those containing 95 wt% or more of cycloartenyl ferulate, particularly preferably Include those containing 98% by weight or more of cycloartenyl ferulate.

  γ-Oryzanol is known, for example, as CAS registration number “11042-64-1”. The γ-oryzanol used in the present invention may include oryzanol A (CAS registration number [21238-33-5]), oryzanol C (CAS registration number [469-36-3]) and the like.

  About the (gamma)-oryzanol used by this invention, the raw material, a manufacturing method, a refinement | purification method, etc. are not specifically limited, For example, what isolated and refine | purified itself from the rice bran etc. is mentioned.

  Further, γ-oryzanol is produced or sold by, for example, Oriza Oil Co., Ltd., Tsukino Food Industry Co., Ltd., Wako Pure Chemical Industries, Ltd., Riken Vitamin Co., Ltd., Okayasu Shoten Co., Ltd., etc. In the emulsified composition, these commercially available products can also be used as γ-oryzanol.

  When γ-oryzanol is contained in the emulsified composition of the present invention, the content is not particularly limited, but is, for example, 0.01 to 10% by weight, preferably 0.1 to 5% by weight, and more preferably 0. 0.5 to 2% by weight, particularly preferably 0.5 to 1% by weight.

  Further, when γ-oryzanol is contained in the emulsified composition of the present invention, the ratio of sodium polyethylene sulfonate and γ-oryzanol is not particularly limited and may be appropriately set within the range satisfying the content of each component described above. For example, γ-oryzanol is 10 to 500 parts by weight, preferably 10 to 300 parts by weight, and more preferably 50 to 200 parts by weight per 100 parts by weight of sodium polyethylene sulfonate.

(Retinol and / or its derivatives)
Retinol is a kind of vitamin A and is a component sometimes referred to as vitamin A alcohol.

  A derivative of retinol is a component having the same skeleton as retinol and obtained by adding a substituent to retinol. The type of retinol derivative is not particularly limited as long as it is pharmaceutically acceptable. For example, an ester of retinol and a fatty acid, an ester of retinol and acetic acid (that is, retinol acetate), an oxide of retinol And esters of the oxide.

  Specific examples of esters of retinol and fatty acids include esters of retinol and fatty acids having 4 to 30 carbon atoms, preferably 10 to 18 carbon atoms. More specifically, as an ester of retinol and a fatty acid, retinol acetate, retinol propionate, retinol butyrate, retinol octylate, retinol laurate, retinol palmitate, retinol stearate, retinol myristic acid Examples thereof include esters, retinol oleic acid esters, retinol linolenic acid esters, and retinol linoleic acid esters. These esters of retinol and fatty acid may be used alone or in combination of two or more.

  Specific examples of the oxide of retinol include retinoic acid (sometimes referred to as “tretinoin”), retinal, and the like. These retinol oxides may be used alone or in combination of two or more.

  Specific examples of the ester of retinol oxide include methyl retinoate, ethyl retinoate, retinol retinoic acid, tocopherol retinoic acid (tocopherol may be any of α, β, γ, or δ). Is mentioned. These oxide esters of retinol may be used alone or in combination of two or more.

  These retinol and / or derivatives thereof are not particularly limited in terms of raw materials, production methods, purification methods, and the like, and those isolated and purified from animals or the like may be used, or commercially available products may be used. Examples of commercially available products of retinol or derivatives thereof include products manufactured or sold by Riken Vitamin Co., Ltd., DSM Nutrition Japan Co., Ltd., Shoka Pharmaceutical Co., Ltd., BASF Japan Co., Ltd. and the like.

  In the emulsified composition of the present invention, one type may be selected from retinol and derivatives thereof, or two or more types may be used in combination.

  Among retinol and derivatives thereof, a retinol derivative is preferable, an ester of retinol and a fatty acid is more preferable, and a retinol palmitate is particularly preferable.

  In the present invention, retinol and / or a derivative thereof may be used in a state dissolved in oil such as vegetable oil. Thus, what dissolved retinol and / or its derivative (s) in oil is known as "vitamin A oil". Vitamin A oil can be produced, for example, according to the method described in the Japanese Pharmacopoeia. As vitamin A oil, the content of retinol and / or a derivative thereof is usually 100,000 to 2 million I.U./g, preferably 500,000 to 1.7 million I.U./g, more preferably 500,000 to One million IU / g can be used. In the present specification, the unit of content of retinol and / or its derivative “I.U.” represents an international unit.

  When retinol and / or a derivative thereof is contained in the emulsified composition of the present invention, the content thereof is not particularly limited. For example, the total amount of retinol and / or a derivative thereof per 100 g of the emulsified composition of the present invention is as follows. 10 to 10 million I.V. U. , Preferably 10,000 to 5 million I.V. U. , More preferably 100,000 to 3 million I.V. U. More preferably, 500,000 to 2 million I.V. U. , Particularly preferably 500,000 to 1 million I.V. U. Is mentioned.

  When vitamin A oil is used as retinol and / or its derivative, the content of vitamin A oil in the emulsified composition of the present invention depends on the content of retinol and / or its derivative in vitamin A oil. What is necessary is just to set so that retinol and / or its derivative may satisfy content mentioned above in the emulsion composition of this invention. Specifically, 1 million I.D. U. / G of retinol and / or a derivative thereof is used, the content of vitamin A oil in the emulsion composition of the present invention is 0.001 to 10% by weight, preferably 0. What is necessary is just to set to 01 to 5 weight%, More preferably, it is 0.1 to 3 weight%, More preferably, it is 0.5 to 2 weight%, Most preferably, you may set to 0.5 to 1 weight%.

  Moreover, when the retinol and / or its derivative are contained in the emulsion composition of the present invention, the ratio of sodium polyethylenesulfonate to retinol and / or its derivative is not particularly limited, and the content of each component described above is For example, the total amount of retinol and / or its derivative may be 50,000 to 6 million I.S. per 1 g of sodium polyethylene sulfonate. U. , Preferably 300,000 to 4 million I.V. U. And more preferably 300,000 to 2 million I.V. U. Is mentioned.

(Tocopherol and / or its derivatives)
Tocopherol is a known ingredient also known as vitamin E. The tocopherol used in the present invention may be either d-form or dl-form, and may have any of α, β, γ, and δ structures. As the tocopherol used in the present invention, specifically, d-α-tocopherol, d-β-tocopherol, d-γ-tocopherol, d-δ-tocopherol, l-α-tocopherol, l-β-tocopherol, Examples include l-γ-tocopherol, l-δ-tocopherol, and mixtures thereof such as dl-α-tocopherol, dl-β-tocopherol, dl-γ-tocopherol, dl-δ-tocopherol, and the like.

  The tocopherol derivative is a component having the same skeleton as that of tocopherol and obtained by adding a substituent to tocopherol.

  The tocopherol derivative used in the present invention may be either d-form or dl-form, and may be any of α, β, γ, and δ structures, as with tocopherol.

  The type of tocopherol derivative is not particularly limited as long as it is pharmaceutically acceptable, and examples thereof include esters of tocopherol and organic acids. Specific examples of the ester of tocopherol and organic acid include tocopherol acetate, tocopherol nicotinate, tocopherol succinate, and tocopherol linolenate. These tocopherol derivatives may be used alone or in combination of two or more.

  These tocopherols and / or derivatives thereof are not particularly limited in terms of raw materials, production methods, purification methods and the like, and those that are isolated and purified by themselves from animals or the like may be used, or commercially available products may be used. Examples of commercially available products of tocopherol and / or derivatives thereof include Riken Vitamin Co., Ltd., Eisai Co., Ltd., Eisai Food Chemical Co., Ltd., DSM Nutrition Japan Co., Ltd., Tama Seikagaku Co., Ltd. Examples include products that are sold.

  In the emulsified composition of the present invention, one type may be selected from tocopherols and / or derivatives thereof, or two or more types may be used in combination.

  Among tocopherols and / or derivatives thereof, tocopherol derivatives are preferable, and tocopherol acetates are more preferable.

  When the tocopherol and / or derivative thereof is contained in the emulsified composition of the present invention, the content is not particularly limited. For example, the total amount of tocopherol and / or the derivative thereof is 0.001 to 10% by weight, preferably Is 0.01 to 5% by weight, more preferably 0.1 to 3% by weight, still more preferably 0.5 to 2% by weight, and particularly preferably 0.5 to 1% by weight.

  Further, when the emulsion composition of the present invention contains tocopherol and / or a derivative thereof, the ratio of sodium polyethylene sulfonate to tocopherol and / or the derivative thereof is not particularly limited, and the content of both components described above is not limited. For example, the total amount of tocopherol and / or a derivative thereof is 5 to 600 parts by weight, preferably 30 to 400 parts by weight, and more preferably 30 to 200 parts by weight per 100 parts by weight of sodium polyethylene sulfonate. Parts by weight.

Oil Phase Base Component The emulsified composition of the present invention contains an oily base such as liquid oil, solid oil or higher alcohol as the base component of the oil phase.

  In the conventional emulsion composition, when liquid oil is contained, the emulsion stability tends to decrease or the viscosity tends to decrease. However, the emulsion composition of the present invention contains liquid oil. In addition, in the case of a water-in-oil type emulsion composition, in addition to the emulsion stability, a high viscosity (appropriate hardness) can be provided. In view of such an effect of the present invention, a preferred example of the oil phase base component used in the emulsion composition of the present invention is liquid oil.

  In the emulsion composition of the present invention, as a base component of the oil phase, by using a combination of a higher alcohol and a liquid oil, the emulsion stability is improved, and in the case of a water-in-oil emulsion composition, The viscosity can be improved more effectively.

  Further, in conventional emulsion compositions, solid oil is known to improve emulsion stability and viscosity, but the solid oil contained in the emulsion composition has a reduced feeling of use. It also contributes. On the other hand, in the present invention, even if it does not contain a solid oil, it can be provided with excellent emulsion stability, and in the case of a water-in-oil type emulsion composition, the viscosity can also be improved. In addition, it is possible to improve the feeling of use by not containing solid oil. In view of such effects of the present invention, a preferred embodiment of the emulsified composition of the present invention includes one that does not substantially contain solid oil.

  Hereinafter, the base component (liquid oil, solid oil, higher alcohol) of the oil phase used in the present invention will be described for each type.

(Liquid oil)
Liquid oil is oil that maintains a liquid form at 25 ° C. The liquid oil used in the present invention is not particularly limited as long as it is usually used in cosmetics, external medicines, etc., for example, vegetable oils such as avocado oil, camellia oil, macadamia pine oil, olive oil, jojoba oil; oleic acid, Fatty acids such as instearic acid; cetyl ethylhexanoate, ethylhexyl palmitate, octyldodecyl myristate, neopentyl glycol diethylhexanoate, glyceryl tri-2-ethylhexanoate, octyldodecyl oleate, isopropyl myristate, glyceryl triisostearate , Ester oils such as divalamethoxycinnamic acid-glyceryl monoethylhexanoate; silicone oils such as dimethylpolysiloxane, methylhydropolyenepolysiloxane, methylphenylpolysiloxane, octamethylcyclotetrasiloxane; Dynamic paraffin, squalene, include liquid hydrocarbon oils such as squalane.

  Among these liquid oils, preferably ester oil, liquid hydrocarbon oil; more preferably octyldodecyl myristate, glyceryl tri-2-ethylhexanoate, octyldodecyl oleate, isopropyl myristate, glyceryl triisostearate, fluid Paraffin; octyldodecyl myristate, glyceryl tri-2-ethylhexanoate, and liquid paraffin are particularly preferable.

  These liquid oils may be used individually by 1 type, and may be used in combination of 2 or more type.

  When liquid oil is contained in the emulsified composition of the present invention, the content is not particularly limited, but may be appropriately set according to the emulsification type, form, use, etc. of the emulsified composition. 01 to 30% by weight, preferably 0.1 to 20% by weight, and more preferably 1 to 20% by weight.

(Solid oil)
A solid oil is an oil that maintains a solid form at 25 ° C. The solid oil used in the present invention may be any oil that is usually used in cosmetics, topical medicines, etc., for example, candelilla wax, rice bran wax, beeswax, cotton wax, carnauba wax, lanolin, shellac wax, ozokerite, ceresin, Polyethylene wax, microcrystalline wax, paraffin, petrolatum, lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, 12-hydroxystearic acid, undecylenic acid, myristyl myristate, cetyl myristate, stearyl stearate, cetyl stearate , Cetyl palmitate, cholesteryl stearate, cholesteryl oleate, dextrin palmitate, inulin stearate, hydrogenated jojoba oil, ceresin wax, solid paraffin wax, poly Chirenwakkusu include solid oils such as silicone waxes.

  Among these solid oils, preferably petrolatum, paraffin, cholesteryl stearate, dextrin palmitate, microcrystalline wax; more preferably petrolatum, dextrin palmitate, microcrystalline wax.

  These solid oils may be used individually by 1 type, and may be used in combination of 2 or more type.

  When solid oil is contained in the emulsified composition of the present invention, the content thereof is not particularly limited, but may be appropriately set according to the emulsification type, form, use, etc. of the emulsified composition. 1 to 50% by weight, preferably 1 to 30% by weight, and more preferably 5 to 15% by weight.

(Higher alcohol)
The higher alcohol is a monohydric alcohol having 6 or more carbon atoms in one molecule. The number of carbon atoms in one molecule in the higher alcohol used in the present invention may be 6 or more, preferably 6 to 34, more preferably 14 to 22.

  The higher alcohol used in the present invention is not limited as long as it is usually used in cosmetics, external medicines and the like. For example, lauryl alcohol, cetyl alcohol, stearyl alcohol, behenyl alcohol, myristyl alcohol, cetostearyl alcohol, cetanol, oleyl Examples include linear higher alcohols such as alcohol; branched higher alcohols such as nostearyl glycerin ether (batyl alcohol).

  Among these higher alcohols, linear higher alcohols are preferable; cetanol, stearyl alcohol, and behenyl alcohols are more preferable; cetanol, stearyl alcohol, and behenyl alcohols are particularly preferable.

  These higher alcohols may be used alone or in combination of two or more.

  When the higher alcohol is contained in the emulsified composition of the present invention, the content thereof is not particularly limited, but may be appropriately set according to the emulsification type, form, use, etc. of the emulsified composition. 1 to 50% by weight, preferably 1 to 30% by weight, and more preferably 3 to 15% by weight.

  In the emulsified composition of the present invention, when the liquid oil and the higher alcohol are used in combination, the ratio thereof is not particularly limited. For example, the higher alcohol is 1 to 200 parts by weight per 100 parts by weight of the liquid oil. The amount is preferably 10 to 150 parts by weight, more preferably 20 to 100 parts by weight.

Water Phase Base Component The emulsified composition of the present invention contains water as a water phase base component. The water content in the emulsified composition of the present invention may be appropriately set according to the emulsification type, form, use, etc. of the emulsified composition, for example, 30 to 90% by weight, preferably 40 to 80% by weight, More preferably, 50-70 weight% is mentioned.

Nonionic Surfactant The emulsified composition of the present invention preferably contains a nonionic surfactant in order to prepare an emulsified form. What is necessary is just to set suitably the nonionic surfactant used by this invention according to the emulsification type of the emulsion composition of this invention.

  Specifically, if the emulsion composition of the present invention is an oil-in-water type, a nonionic surfactant mainly having an HLB value of about 2 to 8 (preferably an HLB value of 2 to 6.5) is used. If the emulsion composition of the present invention is made into a water-in-oil type, a nonionic surfactant mainly having an HLB value of about 8 to 17 (preferably an HLB value of 10 to 17) is used. Use it. Moreover, the HLB value as the whole surfactant to be used can also be adjusted and used combining the thing of 2-8 of HLB value, and the thing of 8-17 of HLB value together. In the present invention, the HLB value of the nonionic surfactant is a value calculated according to the Kawakami method (HLB value = 7 + 11.7 log (sum of formula amount of hydrophilic part / sum of formula amount of lipophilic part)). It is.

  The content of the nonionic surfactant in the emulsion composition of the present invention may be appropriately set according to the emulsion type of the emulsion composition, the type of nonionic surfactant used, etc. -20% by weight, preferably 1-10% by weight, more preferably 1-5% by weight.

  Hereinafter, the types of nonionic surfactants used in the present invention are mainly used for water-in-oil type (HLB value is about 2 to 8), and mainly used for oil-in-water type. This is divided into those used in the above (HLB value is about 8 to 17).

(Nonionic surfactant having an HLB value of about 2 to 8)
Examples of the nonionic surfactant (HLB value of about 2 to 8) mainly used when the emulsion composition of the present invention is made into a water-in-oil type include, for example, polyglycerin fatty acid ester, glycerin fatty acid ester, sorbitan fatty acid. Examples include esters, propylene glycol fatty acid esters, polyoxyethylene hydrogenated castor oil, and polyoxyethylene polyoxypropylene alkyl ethers.

  Specific examples of polyglycerin fatty acid esters include polyglyceryl-2 stearate, polyglyceryl-2 oleate, polyglyceryl-2 isostearate, polyglyceryl-2 triisostearate, polyglyceryl-4 stearate, polyglyceryl-4 oleate, triglyceryl-4 Polyglyceryl stearate-6, polyglyceryl pentastearate, polyglyceryl-10 pentahydroxystearate, polyglyceryl-10 pentaisostearate, polyglyceryl-10 pentaoleate, polyglyceryl-6 polyricinoleate, polyglyceryl-10 polyricinoleate Can be mentioned.

  Specific examples of the glycerin fatty acid ester include glyceryl myristate, glyceryl stearate, glyceryl isostearate, glyceryl oleate, and glyceryl distearate.

  Specific examples of the sorbitan fatty acid ester include sorbitan stearate, sorbitan isostearate, sorbitan sesquiisostearate, sorbitan sesquioleate, sorbitan oleate, sorbitan trioleate, and the like.

  Specific examples of the propylene glycol fatty acid ester include propylene glycol stearate, propylene glycol isostearate, propylene glycol oleate, and the like.

  Specific examples of the polyoxyethylene hydrogenated castor oil include PEG-5 hydrogenated castor oil.

  Specific examples of the polyoxyethylene polyoxypropylene alkyl ether include PPG-4 ceteth-1.

  Among these nonionic surfactants having an HLB value of about 2 to 8, polyglycerin fatty acid ester is preferable, and polyglyceryl-2 oleate is more preferable.

  These nonionic surfactants having an HLB value of about 2 to 8 may be used singly or in combination of two or more.

(Nonionic surfactant having an HLB value of about 8 to 17)
Examples of the nonionic surfactant (HLB value of about 8 to 17) mainly used when the emulsion composition of the present invention is an oil-in-water type include, for example, glycerin fatty acid ester, polyglycerin fatty acid ester, polyoxyethylene glycerin. Examples include fatty acid esters, sorbitan fatty acid esters, polyoxyethylene sorbitan fatty acid esters, polyoxyethylene sorbitan fatty acid esters, polyoxyethylene hydrogenated castor oil, polyoxyethylene alkyl ethers, polyethylene glycol fatty acid esters, and lecithin derivatives.

  Specific examples of the glycerin fatty acid ester include self-emulsifying glyceryl monostearate.

  Specific examples of the polyglycerin fatty acid ester include polyglyceryl-6 laurate, polyglyceryl-10 myristate, and polyglyceryl-10 isostearate.

  Specific examples of the polyoxyethylene glycerin fatty acid ester include PEG-5 glyceryl stearate, PEG-15 glyceryl stearate, PEG-5 glyceryl oleate, PEG-15 glyceryl oleate, and the like.

  Specific examples of sorbitan fatty acid esters include coconut fatty acid sorbitan and sorbitan palmitate.

  Specific examples of the polyoxyethylene sorbitan fatty acid ester include polysorbate 40, polysorbate 60, polysorbate 80, PEG-6 sorbitan stearate, PEG-20 sorbitan isostearate and the like.

  Specific examples of the polyoxyethylene sorbite fatty acid ester include lauric acid sorbes-6, tetrasorbic acid sorbes-6, tetraoleic acid sorbes-30, and tetraoleic acid sorbes-60.

  Specific examples of the polyoxyethylene hydrogenated castor oil include PEG-10 hydrogenated castor oil, PEG-20 hydrogenated castor oil, PEG-30 hydrogenated castor oil, and the like.

  Specific examples of the polyoxyethylene alkyl ether include polyoxyethylene cetyl ether, polyoxyethylene stearyl ether, polyoxyethylene oleyl ether, polyoxyethylene behenyl ether and the like.

  Specific examples of polyethylene glycol fatty acid esters include lauric acid PEG-10, stearic acid PEG-10, stearic acid PEG-25, stearic acid PEG-40, stearic acid PEG-45, stearic acid PEG-55, and oleic acid. PEG-10, distearic acid PEG-150, diisostearic acid PEG-8, etc. are mentioned.

  Specific examples of lecithin derivatives include hydrogenated lecithin and hydrogenated lysolecithin.

  Among these nonionic surfactants having an HLB value of about 8 to 17, preferably a polyglycerin fatty acid ester, a glycerin fatty acid ester, a sorbitan fatty acid ester, a propylene glycol fatty acid ester, a polyoxyethylene alkyl ether, and more preferably a glycerin fatty acid ester. , Polyoxyethylene alkyl ether, more preferably polyoxyethylene alkyl ether, particularly preferably polyoxyethylene behenyl ether.

  These nonionic surfactants having an HLB value of about 8 to 17 may be used alone or in combination of two or more.

Polyhydric alcohol The emulsified composition of the present invention may contain a polyhydric alcohol as necessary for imparting moisture retention or the like.

  Any polyhydric alcohol may be used as long as it is usually used in cosmetics, external medicines and the like. For example, ethylene glycol, 1,3-butylene glycol, propylene glycol, isoprene glycol, diethylene glycol, dipropylene glycol, polypropylene glycol, glycerin. Etc. Among these polyhydric alcohols, 1,3-butylene glycol and glycerin are preferable.

  These polyhydric alcohols may be used individually by 1 type, and may be used in combination of 2 or more type.

  When polyhydric alcohol is contained in the emulsified composition of the present invention, the content thereof is not particularly limited, but is, for example, 1 to 40% by weight, preferably 3 to 30% by weight, and more preferably 5 to 20% by weight. %.

Other Components The emulsion composition of the present invention may contain other pharmacological components as necessary in addition to the components described above. Examples of such pharmacological components include antihistamines (diphenhydramine, diphenhydramine hydrochloride, etc.), local anesthetics (procaine, tetracaine, bupipacaine, mepipacaine, chloroprocaine, propalacaine, meprilucaine or salts thereof, orthocaine, oxesasein, oxypolyentoxy Decane, funnel extract, percaminpase, tesit decite, etc.), anti-inflammatory agents (indomethacin, felbinac, diclofenac sodium, loxoprofen sodium, etc.), skin protectants (collodion, castor oil, etc.), blood circulation promoting components (nonyl acid vanillylamide, nicotinic acid benzyl ester) , Capsaicin, pepper extract, etc.), refreshing agents (menthol, camphor, borneol, mint water, mint oil, etc.), mucopolysaccharide (con Roichin sodium sulfate, glucosamine, etc.) and the like.

  Moreover, the emulsion composition of this invention may contain the other base and additive required for formulation etc. other than the component mentioned above as needed. Such additives are not particularly limited as long as they are pharmaceutically acceptable. For example, aqueous bases such as lower alcohols (ethanol, isopropanol, etc.); cationic surfactants, anionic surfactants , Surfactants such as amphoteric surfactants; preservatives (methyl paraben, propyl paraben, benzoic acid, sodium benzoate, sorbic acid, etc.), flavoring agents (citral, 1,8-shionale, citronellal, farnesol, etc.) , Coloring agents (tar dyes (brown 201, blue 201, yellow 4, yellow 403, etc.), cacao dyes, chlorophyll, aluminum oxide, etc.), thickeners (carboxyvinyl polymer, hypromellose, polyvinylpyrrolidone, sodium alginate) , Ethyl cellulose, carboxymethyl cellulose , Xanthan gum, carrageenan, etc.), pH adjuster (phosphoric acid, hydrochloric acid, citric acid, sodium citrate, succinic acid, tartaric acid, sodium hydroxide, potassium hydroxide, triethanolamine, triisopropanolamine, etc.), wetting agent (dl -Sodium pyrrolidonecarboxylate solution, D-sorbitol solution, macrogol, etc.), stabilizer (dibutylhydroxytoluene, butylhydroxyanisole, sodium edetate, sodium metaphosphate, L-arginine, L-aspartic acid, DL-alanine, Glycine, sodium erythorbate, propyl gallate, sodium sulfite, sulfur dioxide, chlorogenic acid, catechin, rosemary extract, etc.), antioxidants, UV absorbers, chelating agents, adhesives, buffers, solubilizers, yes Addition of solubilizers, preservatives, etc. Agents.

Emulsification type / product form The emulsification type of the emulsion composition of the present invention may be either a water-in-oil type or an oil-in-water type, preferably a water-in-oil type. In the case of the water-in-oil type, the emulsion stability can be improved more effectively, and the viscosity can be further increased to provide a good hardness as an external preparation. Furthermore, when the emulsified composition of the present invention is a water-in-oil type and contains liquid oil and benzyl nicotinate, it is possible to exert a blood circulation promoting action that is remarkably excellent.

  Further, the viscosity when the emulsion composition of the present invention is a water-in-oil type varies depending on the type and amount of the oily base used, but for example, the viscosity at 25 ° C. is 10,000 mPa · s. As mentioned above, Preferably it is 10,000-1 million mPa * s, More preferably, it is 100,000-500,000 mPa * s, Most preferably, 300,000-500,000 mPa * s is mentioned. Here, as for the viscosity at 25 ° C., 45 g of the emulsified composition was filled in a screw tube (50 ml), and the spindle TE used in a Brookfield rotational viscometer (B-type viscometer, DV-II manufactured by BROOK Field) was used. The value obtained by measurement under the conditions of 20 rpm and 3 minutes after the start of rotation.

  The emulsified composition of the present invention is used as an external preparation such as cosmetics and external medicines. The product form of the emulsified composition of the present invention is not particularly limited, and examples thereof include creams, ointments, emulsions, gels, oils, lotions, liniments, and aerosols. Among these, creams, ointments, emulsions, and lotions are preferable.

  When the emulsified composition of the present invention contains benzyl nicotinate, particularly when it contains benzyl nicotinate and is a water-in-oil type, it can exert a blood circulation promoting action, so that maintenance or recovery of a healthy skin state, skin It can be used for the purpose of anti-aging, internal bleeding (bruising, etc.), muscle pain, stiff shoulders, scars caused by injuries and burns, moistness, and improvement of keratinization of fingers.

Production Method The emulsified composition of the present invention can be produced according to a known method for preparing an emulsified preparation depending on the emulsification type. For example, as a method for producing the emulsified composition of the present invention, the components to be contained are divided into a water-soluble component and an oil component, and an aqueous phase containing a water-soluble component and an oil phase containing an oil-based component are prepared, The method of emulsifying according to a well-known method is mentioned.

2. Emulsion Stabilizer and Emulsification Stabilization Method The emulsion stabilizer of the present invention is used for improving the emulsion stability of an emulsion composition, and is characterized by containing sodium polyethylene sulfonate. In addition, the emulsion stabilization method of the present invention is characterized by adding sodium polyethylene sulfonate to the emulsion composition.

  In the emulsion stabilizer and emulsion stabilization method of the present invention, the type and amount of sodium polyethylene sulfonate used, other components and contents contained in the emulsion composition, the emulsion type and product form of the emulsion composition Etc. are as described in the column of “1. Emulsion composition”.

  EXAMPLES The present invention will be described more specifically with reference to the following examples, but the present invention is not limited to these examples.

Test Example 1: Evaluation of emulsion stability of oil-in-water emulsion composition An oil-in-water emulsion composition (cream) having the composition shown in Table 1 was prepared. Specifically, an oil phase raw material was prepared by mixing an oil component, a surfactant, a higher alcohol, and a liquid oil and heating and dissolving at 80 ° C. Separately, an aqueous component, a polyhydric alcohol, and an aqueous base were mixed and dissolved by heating at 80 ° C. to prepare an aqueous phase raw material. The oil phase raw material heated to 80 ° C. was gradually added to the aqueous phase raw material heated to 80 ° C. and emulsified using a homomixer. Then, the oil-in-water type emulsion composition was obtained by cooling to 35 degree | times, stirring.

Each obtained oil-in-water emulsion composition was filled in a screw tube (capacity: 13.5 ml) and allowed to stand in a thermostatic bath at 60 ° C. for 3 days, and then the appearance of each oil-in-water emulsion composition was visually observed. Then, the emulsion stability was evaluated according to the following criteria.
<Evaluation criteria for emulsion stability>
(Double-circle): Separation of an oil phase and a liquid phase is not recognized, and the property has not changed.
○: Separation of the oil phase and the liquid phase is not recognized, but the properties are slightly changed.
Δ: Some separation of oil phase and liquid phase is observed.
X: Separation of the oil phase and the liquid phase is observed.

  The obtained results are shown in Table 1. From these results, it was confirmed that sodium polyethylene sulfonate has an action of improving the emulsion stability of the oil-in-water emulsion composition (Examples 1 and 2). In particular, even when nicotinic acid benzyl ester, which tends to lower the emulsion stability, was contained, the emulsion stability of the oil-in-water emulsion composition was improved by sodium polyethylenesulfonate (Example 2).

Test Example 2: Evaluation of emulsion stability of water-in-oil emulsion composition Water-in-oil emulsion compositions (cream agents) having the compositions shown in Table 2 were prepared. Specifically, an oil phase raw material was prepared by mixing an oil component, a surfactant, a higher alcohol, a liquid oil, and a solid oil and dissolving by heating at 80 ° C. Separately, an aqueous component, a polyhydric alcohol, and an aqueous base were mixed and dissolved by heating at 80 ° C. to prepare an aqueous phase raw material. The oil phase material heated to 80 ° C. was gradually added to the oil phase material heated to 80 ° C. while applying a disper to emulsify. Then, it cooled to 35 degree | times, stirring, and the water-in-oil type emulsion composition was obtained.

  Each obtained water-in-oil emulsion composition is filled into a screw tube (capacity: 13.5 ml) and stored at 60 ° C. for 3 days, emulsion stability after high temperature cycle test, and low temperature cycle test. The subsequent emulsion stability was evaluated. The emulsion stability after storage at 60 ° C. for 3 days was tested under the same conditions as in Test Example 1. Regarding the emulsion stability after the high temperature cycle test, the temperature change from −20 ° C. to 42 ° C. and then the temperature decrease from 42 ° C. to −20 ° C. over 24 hours is taken as one cycle for a total of 7 days ( 7 cycles). In addition, regarding the emulsion stability after the low-temperature cycle test, the temperature change from -20 ° C. to 5 ° C. and then the temperature decrease from 5 ° C. to -20 ° C. is performed over 24 hours, and a total of 7 Day (7 cycles). The appearance of the water-in-oil emulsion composition after each test was visually confirmed, and the emulsion stability was evaluated according to the same criteria as in Test Example 1.

  The obtained results are shown in Table 2. From this result, it was confirmed that sodium polyethylenesulfonate has an action of improving the emulsion stability of the water-in-oil emulsion composition (Examples 3 to 6). Moreover, even when it contained nicotinic acid benzyl ester which tends to reduce emulsion stability, the emulsion stability of the water-in-oil emulsion composition was improved by the sodium polyethylene sulfonate (Examples 4 and 5).

  Furthermore, from the comparison of Comparative Examples 3-4 and Comparative Examples 5-6, the water-in-oil emulsion composition containing solid oil tends to improve the emulsion stability as compared with the case where no solid oil is contained. However, when sodium polyethylene sulfonate was included, excellent emulsification stability was recognized even if it did not contain solid oil (Examples 3 and 4). Moreover, in the water-in-oil emulsion composition containing sodium polyethylene sulfonate, the case where the solid oil is not contained (Examples 3 and 4) is compared with the case where the solid oil is contained (Examples 5 and 6). There was little stickiness and the usability was good.

  Moreover, in the water-in-oil emulsion composition containing sodium polyethylenesulfonate (Examples 3 to 6), the oil-in-water emulsion composition containing sodium polyethylenesulfonate prepared in Test Example 1 (Examples 1 and 2). It was also confirmed that the emulsion stability was further increased compared to

Test Example 3: Evaluation of Viscosity of Water-in-Oil Emulsion Composition Measurement of viscosity at 25 ° C. of water-in-oil emulsion compositions prepared in Test Example 2 (Examples 3 to 6 and Comparative Examples 3 to 6). went. Viscosity at 25 ° C was measured by filling 45 g of each water-in-oil emulsion composition into a screw tube (50 ml) and using a Brookfield rotational viscometer (B-type viscometer, DV-II manufactured by BROOK Field). It was determined by measuring under conditions of spindle TE, rotation speed 20 rpm, and 3 minutes after the start of rotation.

  The obtained results are shown in Table 3. As a result, it was confirmed that the viscosity can be increased by adding sodium polyethylene sulfonate to the water-in-oil emulsion composition (Examples 3 to 6). Moreover, even when it contained nicotinic acid benzyl ester which tends to reduce emulsion stability, the viscosity of the water-in-oil emulsion composition could be increased by sodium polyethylenesulfonate (Examples 4 and 5). . In addition, the water-in-oil emulsion composition containing sodium polyethylene sulfonate had a high viscosity and a hardness suitable as an external preparation even when solid oil was not contained (Examples 3 and 4).

Test Example 4: Evaluation of blood circulation promoting action Oil-in-water emulsion composition prepared in Test Example 1 (Example 1 and Comparative Example 1) and water-in-oil emulsion composition prepared in Test Example 2 (Example) 3 and 5 and Comparative Examples 3, 5) were used to evaluate the blood circulation promoting action.

  Specifically, first, a 1 cm square frame was created inside the subject's forearm, and the color difference before the start of the test was measured using ANTERA 3D (manufactured by Gadelius Medical Co., Ltd.). Next, 0.05 g of each emulsified composition was applied to a 1 cm square frame, and after 8 minutes, the color difference of the applied part was measured using ANTERA 3D. The a value and ΔE value obtained by the measurement were compared with the values before the start of the test, and the amount of change after 8 minutes was calculated.

  Table 4 shows the obtained results. From this result, when benzyl nicotinate was contained in the emulsion composition, blood circulation promoting action was seen in any case, but in the case of a water-in-oil emulsion composition, redness of the skin was particularly noticeable, The blood circulation promoting action was remarkably increased.

Formulation Example A water-in-oil emulsion composition (cream agent) having the composition shown in Table 5 was produced. The specific manufacturing method is the same as in the case of Test Example 2. When the obtained water-in-oil emulsion composition was evaluated for emulsion stability by the same method as in Test Example 2, all of them had excellent emulsion stability. About the obtained water-in-oil emulsion composition, when the viscosity was evaluated by the same method as in Test Example 3, it was also confirmed that the composition had a high viscosity. Further, among the obtained water-in-oil emulsion compositions, the preoperative examples 1, 3, 5, 7 and 8 were evaluated for blood circulation promoting action by the same method as in Test Example 4, and all were excellent. A blood circulation promoting action was observed.

Claims (7)

  An emulsified composition containing sodium polyethylene sulfonate.   The emulsified composition according to claim 1, comprising at least one oily component selected from the group consisting of benzyl nicotinate, γ-oryzanol, retinol, a derivative of retinol, tocopherol, and a derivative of tocopherol.   The emulsified composition according to claim 1 or 2, comprising liquid oil.   The emulsified composition according to any one of claims 1 to 3, which does not contain solid oil.   The emulsified composition according to any one of claims 1 to 4, which is a water-in-oil type.   An emulsion stabilizer comprising sodium polyethylene sulfonate.   An emulsification stabilization method comprising adding sodium polyethylene sulfonate to an emulsified composition.