JP2017538729A - 甲状腺機能亢進症を減少させるための方法および組成物 - Google Patents
甲状腺機能亢進症を減少させるための方法および組成物 Download PDFInfo
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- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- UQZIYBXSHAGNOE-XNSRJBNMSA-N stachyose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO[C@@H]3[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O3)O)O2)O)O1 UQZIYBXSHAGNOE-XNSRJBNMSA-N 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- JIWBIWFOSCKQMA-UHFFFAOYSA-N stearidonic acid Natural products CCC=CCC=CCC=CCC=CCCCCC(O)=O JIWBIWFOSCKQMA-UHFFFAOYSA-N 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- TUNFSRHWOTWDNC-HKGQFRNVSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCC[14C](O)=O TUNFSRHWOTWDNC-HKGQFRNVSA-N 0.000 description 1
- 235000019157 thiamine Nutrition 0.000 description 1
- 229960003495 thiamine Drugs 0.000 description 1
- 239000011721 thiamine Substances 0.000 description 1
- KYMBYSLLVAOCFI-UHFFFAOYSA-N thiamine Chemical compound CC1=C(CCO)SCN1CC1=CN=C(C)N=C1N KYMBYSLLVAOCFI-UHFFFAOYSA-N 0.000 description 1
- 229960000874 thyrotropin Drugs 0.000 description 1
- 230000001748 thyrotropin Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- FGMPLJWBKKVCDB-UHFFFAOYSA-N trans-L-hydroxy-proline Natural products ON1CCCC1C(O)=O FGMPLJWBKKVCDB-UHFFFAOYSA-N 0.000 description 1
- ZCIHMQAPACOQHT-ZGMPDRQDSA-N trans-isorenieratene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/c1c(C)ccc(C)c1C)C=CC=C(/C)C=Cc2c(C)ccc(C)c2C ZCIHMQAPACOQHT-ZGMPDRQDSA-N 0.000 description 1
- KBPHJBAIARWVSC-XQIHNALSSA-N trans-lutein Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2C(=CC(O)CC2(C)C)C KBPHJBAIARWVSC-XQIHNALSSA-N 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 239000004474 valine Substances 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 235000019163 vitamin B12 Nutrition 0.000 description 1
- 239000011715 vitamin B12 Substances 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 235000019166 vitamin D Nutrition 0.000 description 1
- 239000011710 vitamin D Substances 0.000 description 1
- 150000003710 vitamin D derivatives Chemical class 0.000 description 1
- 235000019143 vitamin K2 Nutrition 0.000 description 1
- 239000011728 vitamin K2 Substances 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 229940011671 vitamin b6 Drugs 0.000 description 1
- 229940046008 vitamin d Drugs 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
- 230000004580 weight loss Effects 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- FJHBOVDFOQMZRV-XQIHNALSSA-N xanthophyll Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2C=C(C)C(O)CC2(C)C FJHBOVDFOQMZRV-XQIHNALSSA-N 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/40—Feeding-stuffs specially adapted for particular animals for carnivorous animals, e.g. cats or dogs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/174—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K40/00—Shaping or working-up of animal feeding-stuffs
- A23K40/20—Shaping or working-up of animal feeding-stuffs by moulding, e.g. making cakes or briquettes
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K40/00—Shaping or working-up of animal feeding-stuffs
- A23K40/25—Shaping or working-up of animal feeding-stuffs by extrusion
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
- A61P5/08—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH for decreasing, blocking or antagonising the activity of the anterior pituitary hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
- A61P5/16—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4 for decreasing, blocking or antagonising the activity of the thyroid hormones
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- Polymers & Plastics (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
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- Veterinary Medicine (AREA)
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Abstract
Description
ビタミンKが甲状腺機能亢進症を減少できることを示すためにネコでインビボ研究を実施した。ネコにビタミンK含有食品を与え、ビタミンK含有食品の摂取前と後にクレアチン、遊離T3、およびTSHの循環レベルを測定した。
Claims (20)
- それを必要とする動物の甲状腺機能亢進症を減少させる方法であって、クレアチニン、トリヨードサイロニン(T3)、および甲状腺刺激ホルモン(TSH)からなる群から選択される1つ以上の因子の循環レベルを減少させるために有効な量のビタミンKを含む食事を前記動物に与える工程を含む方法。
- 前記動物がネコである、請求項1に記載の方法。
- 前記食事が前記動物のクレアチニンの循環レベルを減少させるために有効なビタミンKの量を含む、請求項1または2に記載の方法。
- 前記食事中のビタミンKの前記量が、前記動物に前記食事を与える前の前記動物のクレアチニンの前記循環レベルと比べて、クレアチニンの循環レベルを少なくとも30%減少させるために有効である、請求項3に記載の方法。
- 前記動物に少なくとも、25日、50日、100日、および125日からなる群から選択される期間の間、前記食事を与えた時、前記食事中のビタミンKの前記量が、前記動物に前記食事を与える前の前記動物のクレアチニンの前記循環レベルと比べて、クレアチニンの循環レベルを少なくとも30%減少させるために有効である、請求項3に記載の方法。
- 前記食事が前記動物のTSHの循環レベルを減少させるために有効なビタミンKの量を含む、請求項1または2に記載の方法。
- 前記食事中のビタミンKの前記量が、前記動物に前記食事を与える前の前記動物のTSHの前記循環レベルと比べて、TSHの循環レベルを少なくとも80%減少させるために有効である、請求項6に記載の方法。
- 前記動物に少なくとも、25日、50日、100日および125日からなる群から選択される期間の間、前記食事を与えた時、前記食事中のビタミンKの前記量が、前記動物に前記食事を与える前の前記動物のTSHの前記循環レベルと比べて、TSHの循環レベルを少なくとも80%減少させるために有効である、請求項6に記載の方法。
- 前記食事が前記動物の遊離T3の循環レベルを減少させるために有効なビタミンKの量を含む、請求項1または2に記載の方法。
- 前記食事中のビタミンKの前記量が、前記動物に前記食事を与える前の前記動物の遊離T3の前記循環レベルと比べて、遊離T3の循環レベルを少なくとも30%減少させるために有効である、請求項9に記載の方法。
- 前記動物に少なくとも、25日、50日、100日、および125日からなる群から選択される期間の間、前記食事を与えた時、前記食事中のビタミンKの前記量が、前記動物に前記食事を与える前の前記動物の遊離T3の前記循環レベルと比べて、遊離T3の循環レベルを少なくとも30%減少させるために有効である、請求項9に記載の方法。
- 動物が食品組成物を摂取した後、前記動物の1つ以上の因子の循環レベルを減少させるために有効な量のビタミンKを含む前記食品組成物であって、前記1つ以上の因子がクレアチニン、トリヨードサイロニン(T3)、および甲状腺刺激ホルモン(TSH)からなる群から選択される食品組成物。
- 前記動物がネコである、請求項12に記載の食品組成物。
- 前記組成物が前記動物のクレアチニンの循環レベルを減少させるために有効なビタミンKの量を含む、請求項12または13に記載の食品組成物。
- 前記組成物が前記動物のTSHの循環レベルを減少させるために有効なビタミンKの量を含む、請求項12または13に記載の食品組成物。
- 前記組成物が前記動物の遊離T3の循環レベルを減少させるために有効なビタミンKの量を含む、請求項12または13に記載の食品組成物。
- 前記動物が少なくとも、25日、50日、100日、および125日からなる群から選択される期間の間、前記食品組成物を摂取した時、前記食品組成物のビタミンKの前記量が、前記動物が前記食品組成物を摂取する前の前記動物のクレアチニン、TSH、および遊離T3の循環レベルと比べて、クレアチニン、TSH、および遊離T3の循環レベルを減少させるために有効である、請求項12または13に記載の食品組成物。
- ペットフード組成物を作製する方法であって、
(a)キブル生地を形成するために湿った成分および乾燥した成分を高温で混合して前処理する工程と、
(b)前記キブル生地を高温および高圧で押し出す工程と、
(c)前記押し出されたキブルを乾燥する工程と、
(d)前記乾燥したキブルの表面に液体および/または乾燥成分をかぶせる工程と、を含み、
前記動物が前記食品組成物を摂取した際に動物の1つ以上の因子の循環レベルを減少させるために有効な量で、ビタミンKが、工程(a)および/または(d)にて前記キブルに加えられるのであり、前記1つ以上の因子が、クレアチニン、トリヨードサイロニン(T3)、および甲状腺刺激ホルモン(TSH)からなる群から選択される方法。 - 前記動物がネコである、請求項18に記載の方法。
- 前記ビタミンKが工程(a)にて前記キブル生地に加えられる、請求項18に記載の方法。
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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PCT/US2014/070989 WO2016099495A1 (en) | 2014-12-17 | 2014-12-17 | Method and composition for reducing hyperthyroidism |
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JP2017538729A true JP2017538729A (ja) | 2017-12-28 |
JP6468617B2 JP6468617B2 (ja) | 2019-02-13 |
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JP2017532768A Active JP6468617B2 (ja) | 2014-12-17 | 2014-12-17 | 甲状腺機能亢進症を減少させるための方法および組成物 |
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US (1) | US20170318837A1 (ja) |
JP (1) | JP6468617B2 (ja) |
FR (1) | FR3030277A1 (ja) |
WO (1) | WO2016099495A1 (ja) |
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JP7026429B2 (ja) | 2017-04-04 | 2022-02-28 | 明治飼糧株式会社 | 反芻家畜の免疫賦活化用飼料組成物 |
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US3196018A (en) * | 1960-08-08 | 1965-07-20 | Galler William | Coated menadione bisulfite adduct |
JPH11500709A (ja) * | 1994-12-22 | 1999-01-19 | バルツ フォルカー | 副甲状腺機能亢進症処置のためのビタミンkグループの使用 |
JP2003508070A (ja) * | 1999-09-09 | 2003-03-04 | ソシエテ デ プロデユイ ネツスル ソシエテ アノニム | 老齢ペットの体調の改善 |
JP2004532829A (ja) * | 2001-03-15 | 2004-10-28 | ディーエスエム アイピー アセッツ ビー.ブイ. | イソフラボンおよび多価不飽和脂肪酸の組合せを含む、骨粗鬆症を予防するための組成物 |
JP2011510621A (ja) * | 2008-01-28 | 2011-04-07 | スペスィアリテ、ペット、フード | ペットフードの嗜好性を増強する方法 |
WO2013095935A1 (en) * | 2011-12-19 | 2013-06-27 | Hill's Pet Nutrition, Inc. | Compositions and methods for diagnosing and treating hyperthyroidism in companion animals |
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DE602004031296D1 (de) * | 2003-06-20 | 2011-03-17 | Hills Pet Nutrition Inc | Verfahren für die schilddrüsenüberfunktion bei der katze sowie zusammensetzungen mit eingeschränktem jodgehalt |
US20050170067A1 (en) * | 2004-02-03 | 2005-08-04 | Bioproducts, Inc. | Potassium pyrophosphate pet food palatability enhancers |
WO2012075138A1 (en) * | 2010-11-30 | 2012-06-07 | Progenetics Llc | Method of producing biologically active vitamin k dependent proteins in transgenic animals |
-
2014
- 2014-12-17 JP JP2017532768A patent/JP6468617B2/ja active Active
- 2014-12-17 US US15/533,248 patent/US20170318837A1/en not_active Abandoned
- 2014-12-17 WO PCT/US2014/070989 patent/WO2016099495A1/en active Application Filing
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2015
- 2015-12-16 FR FR1562551A patent/FR3030277A1/fr active Pending
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
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US3196018A (en) * | 1960-08-08 | 1965-07-20 | Galler William | Coated menadione bisulfite adduct |
JPH11500709A (ja) * | 1994-12-22 | 1999-01-19 | バルツ フォルカー | 副甲状腺機能亢進症処置のためのビタミンkグループの使用 |
JP2003508070A (ja) * | 1999-09-09 | 2003-03-04 | ソシエテ デ プロデユイ ネツスル ソシエテ アノニム | 老齢ペットの体調の改善 |
JP2004532829A (ja) * | 2001-03-15 | 2004-10-28 | ディーエスエム アイピー アセッツ ビー.ブイ. | イソフラボンおよび多価不飽和脂肪酸の組合せを含む、骨粗鬆症を予防するための組成物 |
JP2011510621A (ja) * | 2008-01-28 | 2011-04-07 | スペスィアリテ、ペット、フード | ペットフードの嗜好性を増強する方法 |
WO2013095935A1 (en) * | 2011-12-19 | 2013-06-27 | Hill's Pet Nutrition, Inc. | Compositions and methods for diagnosing and treating hyperthyroidism in companion animals |
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JP6468617B2 (ja) | 2019-02-13 |
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