JP2017536403A5 - - Google Patents
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- JP2017536403A5 JP2017536403A5 JP2017529646A JP2017529646A JP2017536403A5 JP 2017536403 A5 JP2017536403 A5 JP 2017536403A5 JP 2017529646 A JP2017529646 A JP 2017529646A JP 2017529646 A JP2017529646 A JP 2017529646A JP 2017536403 A5 JP2017536403 A5 JP 2017536403A5
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- JP
- Japan
- Prior art keywords
- tipifarnib
- administered
- hdv
- bid
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- NCDNCNXCDXHOMX-XGKFQTDJSA-N ritonavir Chemical group N([C@@H](C(C)C)C(=O)N[C@H](C[C@H](O)[C@H](CC=1C=CC=CC=1)NC(=O)OCC=1SC=NC=1)CC=1C=CC=CC=1)C(=O)N(C)CC1=CSC(C(C)C)=N1 NCDNCNXCDXHOMX-XGKFQTDJSA-N 0.000 claims description 50
- NCDNCNXCDXHOMX-UHFFFAOYSA-N Ritonavir Natural products C=1C=CC=CC=1CC(NC(=O)OCC=1SC=NC=1)C(O)CC(CC=1C=CC=CC=1)NC(=O)C(C(C)C)NC(=O)N(C)CC1=CSC(C(C)C)=N1 NCDNCNXCDXHOMX-UHFFFAOYSA-N 0.000 claims description 47
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- UUYQXLQNUVEFGD-UHFFFAOYSA-M sodium;hydrogen carbonate;6-methoxy-2-[(4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfinyl]-1h-benzimidazole Chemical compound [Na+].OC([O-])=O.N1C2=CC(OC)=CC=C2N=C1S(=O)CC1=NC=C(C)C(OC)=C1C UUYQXLQNUVEFGD-UHFFFAOYSA-M 0.000 description 1
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- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
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- 239000000375 suspending agent Substances 0.000 description 1
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- 230000009885 systemic effect Effects 0.000 description 1
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- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
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| US201462087692P | 2014-12-04 | 2014-12-04 | |
| US62/087,692 | 2014-12-04 | ||
| PCT/US2015/063674 WO2016090107A2 (en) | 2014-12-04 | 2015-12-03 | Treatment of hepatitis delta virus infection |
Related Child Applications (1)
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| JP2020152721A Division JP2021006538A (ja) | 2014-12-04 | 2020-09-11 | デルタ肝炎ウイルス感染の治療 |
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| JP2017536403A JP2017536403A (ja) | 2017-12-07 |
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| JP2017529646A Withdrawn JP2017536403A (ja) | 2014-12-04 | 2015-12-03 | デルタ肝炎ウイルス感染の治療 |
| JP2020152721A Pending JP2021006538A (ja) | 2014-12-04 | 2020-09-11 | デルタ肝炎ウイルス感染の治療 |
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| EP (1) | EP3226973A4 (enExample) |
| JP (2) | JP2017536403A (enExample) |
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| US10076512B2 (en) | 2014-05-01 | 2018-09-18 | Eiger Biopharmaceuticals, Inc. | Treatment of hepatitis delta virus infection |
| US11311519B2 (en) | 2014-05-01 | 2022-04-26 | Eiger Biopharmaceuticals, Inc. | Treatment of hepatitis delta virus infection |
| JP2017536403A (ja) * | 2014-12-04 | 2017-12-07 | アイガー・バイオファーマシューティカルズ・インコーポレイテッドＥｉｇｅｒ Ｂｉｏｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | デルタ肝炎ウイルス感染の治療 |
| KR20220147695A (ko) | 2015-04-21 | 2022-11-03 | 아이거 바이오파마슈티컬스 인코포레이티드 | 로나파르닙 및 리토나버를 포함하는 약제 조성물 |
| WO2024223797A1 (en) * | 2023-04-28 | 2024-10-31 | Institut National de la Santé et de la Recherche Médicale | Use of cyp3a4 inhibitors for the treatment of hepatitis d virus (hdv) infections |
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| US20030181355A1 (en) * | 1992-05-29 | 2003-09-25 | Glenn Jeffrey S. | Method for inhibition of viral infection |
| AU6605196A (en) * | 1996-02-29 | 1997-09-16 | Duke University | Method of treating hepatitis delta virus infection |
| ES2200591T3 (es) * | 1998-12-23 | 2004-03-01 | Janssen Pharmaceutica N.V. | Derivados de 1,2-quinolina anelados. |
| EP1284720B1 (en) * | 2000-03-29 | 2006-09-13 | Georgetown University | L-fmau for the treatment of hepatitis delta viral infection |
| JO2361B1 (en) * | 2000-06-22 | 2006-12-12 | جانسين فارماسيوتيكا ان. في | Enaniumer 1,2-anylated quinoline inhibitor for the transporter - farnesyl |
| EP2362218B1 (en) * | 2004-11-05 | 2014-08-27 | Janssen Pharmaceutica N.V. | Methods of monitoring the efficacy of farnesyltransferase inhibitors |
| WO2011088126A2 (en) * | 2010-01-13 | 2011-07-21 | Eiger Biopharmaceuticals, Inc. | Treatment of viral infection with prenyltransferase inhibitors |
| ES2533213T3 (es) * | 2011-04-01 | 2015-04-08 | Novartis Ag | Tratamiento para infección con el virus de hepatitis B solo o en combinación con el virus de hepatitis Delta y enfermedades hepáticas asociadas |
| BR112013032381B1 (pt) * | 2011-06-14 | 2021-01-12 | Globeimmune, Inc. | composições à base de levedura e métodos para o tratamento ou prevenção de infecção pelo vírus da hepatite delta |
| SG2014011670A (en) * | 2011-10-21 | 2014-10-30 | Abbvie Inc | Combination treatment (eg. with abt-072 or abt -333) of daas for use in treating hcv |
| CA2863662A1 (en) * | 2012-02-03 | 2013-08-08 | Gilead Sciences, Inc. | Combination therapy comprising tenofovir alafenamide hemifumarate and cobicistat for use in the treatment of viral infections |
| JP2015536950A (ja) * | 2012-11-02 | 2015-12-24 | ファーマサイクリックス，インク． | Ｔｅｃファミリーキナーゼ阻害剤アジュバント療法 |
| JP2017536403A (ja) * | 2014-12-04 | 2017-12-07 | アイガー・バイオファーマシューティカルズ・インコーポレイテッドＥｉｇｅｒ Ｂｉｏｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | デルタ肝炎ウイルス感染の治療 |
-
2015
- 2015-12-03 JP JP2017529646A patent/JP2017536403A/ja not_active Withdrawn
- 2015-12-03 US US15/531,695 patent/US20180338993A1/en not_active Abandoned
- 2015-12-03 EP EP15865819.5A patent/EP3226973A4/en not_active Withdrawn
- 2015-12-03 WO PCT/US2015/063674 patent/WO2016090107A2/en not_active Ceased
-
2020
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2021
- 2021-03-10 US US17/197,687 patent/US20220023287A1/en not_active Abandoned
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