JP2017536403A5 - - Google Patents
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- JP2017536403A5 JP2017536403A5 JP2017529646A JP2017529646A JP2017536403A5 JP 2017536403 A5 JP2017536403 A5 JP 2017536403A5 JP 2017529646 A JP2017529646 A JP 2017529646A JP 2017529646 A JP2017529646 A JP 2017529646A JP 2017536403 A5 JP2017536403 A5 JP 2017536403A5
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- JP
- Japan
- Prior art keywords
- tipifarnib
- administered
- hdv
- bid
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- NCDNCNXCDXHOMX-XGKFQTDJSA-N ritonavir Chemical group N([C@@H](C(C)C)C(=O)N[C@H](C[C@H](O)[C@H](CC=1C=CC=CC=1)NC(=O)OCC=1SC=NC=1)CC=1C=CC=CC=1)C(=O)N(C)CC1=CSC(C(C)C)=N1 NCDNCNXCDXHOMX-XGKFQTDJSA-N 0.000 claims description 50
- NCDNCNXCDXHOMX-UHFFFAOYSA-N Ritonavir Natural products C=1C=CC=CC=1CC(NC(=O)OCC=1SC=NC=1)C(O)CC(CC=1C=CC=CC=1)NC(=O)C(C(C)C)NC(=O)N(C)CC1=CSC(C(C)C)=N1 NCDNCNXCDXHOMX-UHFFFAOYSA-N 0.000 claims description 47
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- UUYQXLQNUVEFGD-UHFFFAOYSA-M sodium;hydrogen carbonate;6-methoxy-2-[(4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfinyl]-1h-benzimidazole Chemical compound [Na+].OC([O-])=O.N1C2=CC(OC)=CC=C2N=C1S(=O)CC1=NC=C(C)C(OC)=C1C UUYQXLQNUVEFGD-UHFFFAOYSA-M 0.000 description 1
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- 235000002906 tartaric acid Nutrition 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- 229960001355 tenofovir disoproxil Drugs 0.000 description 1
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| PCT/US2015/063674 WO2016090107A2 (en) | 2014-12-04 | 2015-12-03 | Treatment of hepatitis delta virus infection |
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| JP2020152721A Pending JP2021006538A (ja) | 2014-12-04 | 2020-09-11 | デルタ肝炎ウイルス感染の治療 |
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| US11311519B2 (en) | 2014-05-01 | 2022-04-26 | Eiger Biopharmaceuticals, Inc. | Treatment of hepatitis delta virus infection |
| US10076512B2 (en) | 2014-05-01 | 2018-09-18 | Eiger Biopharmaceuticals, Inc. | Treatment of hepatitis delta virus infection |
| EP3226973A4 (en) * | 2014-12-04 | 2018-05-30 | Eiger Biopharmaceuticals, Inc. | Treatment of hepatitis delta virus infection |
| US10835496B2 (en) | 2015-04-21 | 2020-11-17 | Eiger Biopharmaceuticals, Inc. | Pharmaceutical compositions comprising lonafarnib and ritonavir |
| LT3416675T (lt) | 2016-02-19 | 2021-06-25 | Eiger Biopharmaceuticals, Inc. | Hepatito delta viruso infekcijos gydymas interferonu lambda |
| WO2024223797A1 (en) * | 2023-04-28 | 2024-10-31 | Institut National de la Santé et de la Recherche Médicale | Use of cyp3a4 inhibitors for the treatment of hepatitis d virus (hdv) infections |
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| US20030181355A1 (en) * | 1992-05-29 | 2003-09-25 | Glenn Jeffrey S. | Method for inhibition of viral infection |
| WO1997031641A1 (en) * | 1996-02-29 | 1997-09-04 | Duke University | Method of treating hepatitis delta virus infection |
| BR9916827A (pt) * | 1998-12-23 | 2001-10-16 | Janssen Pharmaceutica Nv | Derivados de quinolina 1,2-anelados |
| CA2405502A1 (en) * | 2000-03-29 | 2001-10-04 | Georgetown University | Method of treating hepatitis delta viral infection |
| JO2361B1 (en) * | 2000-06-22 | 2006-12-12 | جانسين فارماسيوتيكا ان. في | Enaniumer 1,2-anylated quinoline inhibitor for the transporter - farnesyl |
| EP1815247B1 (en) * | 2004-11-05 | 2013-02-20 | Janssen Pharmaceutica NV | Therapeutic use of farnesyltransferase inhibitors and methods of monitoring the efficacy thereof |
| WO2011088126A2 (en) * | 2010-01-13 | 2011-07-21 | Eiger Biopharmaceuticals, Inc. | Treatment of viral infection with prenyltransferase inhibitors |
| PL2694087T3 (pl) * | 2011-04-01 | 2015-06-30 | Novartis Ag | Leczenie zakażenia wirusem zapalenia wątroby typu B samego lub w połączeniu z zakażeniem wirusem zapalenia wątroby typu delta i towarzyszącymi chorobami wątroby |
| WO2012174220A1 (en) * | 2011-06-14 | 2012-12-20 | Globeimmune, Inc. | Yeast-based compositions and methods for the treatment or prevention of hepatitis delta virus infection |
| CN104023726A (zh) * | 2011-10-21 | 2014-09-03 | 艾伯维公司 | 用于治疗hcv的一种或多种daa的联合治疗(例如，与abt-072或abt-333) |
| MD20140091A2 (ro) * | 2012-02-03 | 2015-01-31 | Gilead Sciences, Inc. | Terapie combinată cuprinzând hemifumarat tenofovir alafenamidă şi cobicistat pentru utilizare în tratamentul infecţiilor virale |
| EP2914263A4 (en) * | 2012-11-02 | 2016-04-27 | Pharmacyclics Inc | ADJUVANT THERAPY WITH TEC FAMILY KINASE INHIBITOR |
| EP3226973A4 (en) * | 2014-12-04 | 2018-05-30 | Eiger Biopharmaceuticals, Inc. | Treatment of hepatitis delta virus infection |
-
2015
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- 2015-12-03 US US15/531,695 patent/US20180338993A1/en not_active Abandoned
- 2015-12-03 WO PCT/US2015/063674 patent/WO2016090107A2/en not_active Ceased
- 2015-12-03 JP JP2017529646A patent/JP2017536403A/ja not_active Withdrawn
-
2020
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2021
- 2021-03-10 US US17/197,687 patent/US20220023287A1/en not_active Abandoned
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