JP2017534874A5 - - Google Patents
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- JP2017534874A5 JP2017534874A5 JP2017523853A JP2017523853A JP2017534874A5 JP 2017534874 A5 JP2017534874 A5 JP 2017534874A5 JP 2017523853 A JP2017523853 A JP 2017523853A JP 2017523853 A JP2017523853 A JP 2017523853A JP 2017534874 A5 JP2017534874 A5 JP 2017534874A5
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- Japan
- Prior art keywords
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- DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 claims 52
- 238000000034 method Methods 0.000 claims 33
- 208000009304 Acute Kidney Injury Diseases 0.000 claims 26
- 208000033626 Renal failure acute Diseases 0.000 claims 26
- 201000011040 acute kidney failure Diseases 0.000 claims 26
- 229940109239 creatinine Drugs 0.000 claims 26
- 210000002966 serum Anatomy 0.000 claims 26
- 210000002700 urine Anatomy 0.000 claims 22
- 210000001124 body fluid Anatomy 0.000 claims 19
- 208000012998 acute renal failure Diseases 0.000 claims 18
- 238000003556 assay Methods 0.000 claims 18
- 230000003907 kidney function Effects 0.000 claims 17
- 239000010839 body fluid Substances 0.000 claims 11
- 210000003734 kidney Anatomy 0.000 claims 11
- 230000006378 damage Effects 0.000 claims 9
- 239000012530 fluid Substances 0.000 claims 9
- 102000044166 interleukin-18 binding protein Human genes 0.000 claims 9
- 108010070145 interleukin-18 binding protein Proteins 0.000 claims 9
- 230000003247 decreasing effect Effects 0.000 claims 4
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 3
- 238000012959 renal replacement therapy Methods 0.000 claims 3
- 201000003126 Anuria Diseases 0.000 claims 2
- 206010061481 Renal injury Diseases 0.000 claims 2
- 208000027418 Wounds and injury Diseases 0.000 claims 2
- 238000011088 calibration curve Methods 0.000 claims 2
- 239000003153 chemical reaction reagent Substances 0.000 claims 2
- 230000007423 decrease Effects 0.000 claims 2
- 238000003745 diagnosis Methods 0.000 claims 2
- ZJAOAACCNHFJAH-UHFFFAOYSA-N phosphonoformic acid Chemical compound OC(=O)P(O)(O)=O ZJAOAACCNHFJAH-UHFFFAOYSA-N 0.000 claims 2
- 238000001356 surgical procedure Methods 0.000 claims 2
- 238000002054 transplantation Methods 0.000 claims 2
- 206010007559 Cardiac failure congestive Diseases 0.000 claims 1
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 claims 1
- 108010036949 Cyclosporine Proteins 0.000 claims 1
- 206010016654 Fibrosis Diseases 0.000 claims 1
- 206010019280 Heart failures Diseases 0.000 claims 1
- 102000001554 Hemoglobins Human genes 0.000 claims 1
- 108010054147 Hemoglobins Proteins 0.000 claims 1
- 206010020772 Hypertension Diseases 0.000 claims 1
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 claims 1
- 102000036675 Myoglobin Human genes 0.000 claims 1
- 108010062374 Myoglobin Proteins 0.000 claims 1
- 208000001647 Renal Insufficiency Diseases 0.000 claims 1
- 206010040047 Sepsis Diseases 0.000 claims 1
- ZSJLQEPLLKMAKR-UHFFFAOYSA-N Streptozotocin Natural products O=NN(C)C(=O)NC1C(O)OC(CO)C(O)C1O ZSJLQEPLLKMAKR-UHFFFAOYSA-N 0.000 claims 1
- QJJXYPPXXYFBGM-LFZNUXCKSA-N Tacrolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1\C=C(/C)[C@@H]1[C@H](C)[C@@H](O)CC(=O)[C@H](CC=C)/C=C(C)/C[C@H](C)C[C@H](OC)[C@H]([C@H](C[C@H]2C)OC)O[C@@]2(O)C(=O)C(=O)N2CCCC[C@H]2C(=O)O1 QJJXYPPXXYFBGM-LFZNUXCKSA-N 0.000 claims 1
- 229940126575 aminoglycoside Drugs 0.000 claims 1
- 238000007675 cardiac surgery Methods 0.000 claims 1
- 229960001265 ciclosporin Drugs 0.000 claims 1
- 230000007882 cirrhosis Effects 0.000 claims 1
- 208000019425 cirrhosis of liver Diseases 0.000 claims 1
- 239000002131 composite material Substances 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 239000002872 contrast media Substances 0.000 claims 1
- 208000029078 coronary artery disease Diseases 0.000 claims 1
- 210000004351 coronary vessel Anatomy 0.000 claims 1
- 230000002596 correlated effect Effects 0.000 claims 1
- 229930182912 cyclosporin Natural products 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 239000002934 diuretic Substances 0.000 claims 1
- 230000001882 diuretic effect Effects 0.000 claims 1
- 208000002296 eclampsia Diseases 0.000 claims 1
- 229940093476 ethylene glycol Drugs 0.000 claims 1
- 229960005102 foscarnet Drugs 0.000 claims 1
- 230000006870 function Effects 0.000 claims 1
- 230000024924 glomerular filtration Effects 0.000 claims 1
- 229910001385 heavy metal Inorganic materials 0.000 claims 1
- HOMGKSMUEGBAAB-UHFFFAOYSA-N ifosfamide Chemical compound ClCCNP1(=O)OCCCN1CCCl HOMGKSMUEGBAAB-UHFFFAOYSA-N 0.000 claims 1
- 229960001101 ifosfamide Drugs 0.000 claims 1
- 208000014674 injury Diseases 0.000 claims 1
- 201000006370 kidney failure Diseases 0.000 claims 1
- 229960000485 methotrexate Drugs 0.000 claims 1
- 238000012544 monitoring process Methods 0.000 claims 1
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 claims 1
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims 1
- 201000011461 pre-eclampsia Diseases 0.000 claims 1
- 238000004393 prognosis Methods 0.000 claims 1
- 201000001474 proteinuria Diseases 0.000 claims 1
- 238000011084 recovery Methods 0.000 claims 1
- 238000013517 stratification Methods 0.000 claims 1
- ZSJLQEPLLKMAKR-GKHCUFPYSA-N streptozocin Chemical compound O=NN(C)C(=O)N[C@H]1[C@@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O ZSJLQEPLLKMAKR-GKHCUFPYSA-N 0.000 claims 1
- 229960001052 streptozocin Drugs 0.000 claims 1
- 229960001967 tacrolimus Drugs 0.000 claims 1
- QJJXYPPXXYFBGM-SHYZHZOCSA-N tacrolimus Natural products CO[C@H]1C[C@H](CC[C@@H]1O)C=C(C)[C@H]2OC(=O)[C@H]3CCCCN3C(=O)C(=O)[C@@]4(O)O[C@@H]([C@H](C[C@H]4C)OC)[C@@H](C[C@H](C)CC(=C[C@@H](CC=C)C(=O)C[C@H](O)[C@H]2C)C)OC QJJXYPPXXYFBGM-SHYZHZOCSA-N 0.000 claims 1
- 238000011282 treatment Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462078347P | 2014-11-11 | 2014-11-11 | |
| US62/078,347 | 2014-11-11 | ||
| PCT/US2015/060204 WO2016077484A1 (en) | 2014-11-11 | 2015-11-11 | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017534874A JP2017534874A (ja) | 2017-11-24 |
| JP2017534874A5 true JP2017534874A5 (enExample) | 2018-12-20 |
Family
ID=55955000
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017523853A Pending JP2017534874A (ja) | 2014-11-11 | 2015-11-11 | 腎損傷および腎不全の診断および予後のための方法および組成物。 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20170315134A1 (enExample) |
| EP (1) | EP3218724A4 (enExample) |
| JP (1) | JP2017534874A (enExample) |
| CN (1) | CN107003325A (enExample) |
| WO (1) | WO2016077484A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7344127B2 (ja) | 2017-05-31 | 2023-09-13 | マース インコーポレーテッド | 慢性腎臓病の診断及び治療方法 |
| CN118549657A (zh) * | 2018-01-19 | 2024-08-27 | 马斯公司 | 生物标志物在制备用于鉴定猫科动物患慢性肾脏病的易感性或降低患病风险的制剂中的用途 |
| WO2020018463A1 (en) * | 2018-07-14 | 2020-01-23 | Mars, Incorporated | Biomarkers and test models for chronic kidney disease |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20120156701A1 (en) * | 2009-12-20 | 2012-06-21 | Joseph Anderberg | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| EP3761034A3 (en) * | 2011-01-26 | 2021-02-17 | University of Pittsburgh - Of the Commonwealth System of Higher Education | Urine biomarkers for prediction of recovery after acute kidney injury: proteomics |
| AU2011377379A1 (en) * | 2011-09-22 | 2014-04-10 | Universidad De Los Andes | Method for monitoring, diagnosis and/or prognosis of acute kidney injury in early stage |
| US20140038203A1 (en) * | 2012-07-09 | 2014-02-06 | Musc Foundation For Research Development | Methods for detecting or predicting kidney disease |
-
2015
- 2015-11-11 US US15/526,271 patent/US20170315134A1/en not_active Abandoned
- 2015-11-11 WO PCT/US2015/060204 patent/WO2016077484A1/en not_active Ceased
- 2015-11-11 EP EP15859966.2A patent/EP3218724A4/en not_active Withdrawn
- 2015-11-11 CN CN201580065880.3A patent/CN107003325A/zh active Pending
- 2015-11-11 JP JP2017523853A patent/JP2017534874A/ja active Pending