JP2017531651A - 移動能力又は動作能力を改善するため、あるいはフレイルを治療するための組成物及び方法 - Google Patents
移動能力又は動作能力を改善するため、あるいはフレイルを治療するための組成物及び方法 Download PDFInfo
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Abstract
Description
[0001]本出願は、2014年10月10日に出願された、米国特許仮出願第62/062,283号に対する優先権を主張するものであり、この開示の全体は本参照により援用される。
[0002]本発明は、概して動物において移動能力及び動作能力を高めるための、及び動物においてフレイルを治療又は予防するための、組成物及び方法に関し、特に、中鎖トリグリセリド類を含む組成物、及び動物において移動能力及び動作能力を高めるための、及び動物においてフレイルを治療又は予防するための、その使用に関する。
[0003]米国人道協会によると、2012年には米国内で1億7900万頭ものペットが所有されており、アメリカ人世帯の62%が少なくとも1頭のペットを飼育している。その内訳としては、犬がおよそ8300万頭を占め、猫が9600万頭を占める。
[0012]本明細書では以下の略記が使用され得る:MCTs、中鎖トリグリセリド類;ALA、α−リノレン酸;DHA、ドコサヘキサエン酸;DPA、ドコサペンタエン酸;EPA、エイコサペンタエン酸;LA、リノール酸;LCPUFA、長鎖多価不飽和脂肪酸(本明細書で使用するとき、LCPUFAは、1種以上のこのような脂肪酸を指す);NO、酸化窒素;NORC、酸化窒素放出化合物;並びにL−Arg、L−アルギニン。
により表わすことができる[式中、R、R’及びR”は、炭素鎖中に6〜12個の炭素原子を有しており、グリセロール鎖に対しエステル化されている]。本発明の脂質は、直接エステル化、転移、分別、又はエステル交換などといった、当該技術分野で既知の任意のプロセスにより調製され得る。例えば、ココナツ油などの植物油の転移により脂質を調製できる。鎖長の長さ及び分布は、原料とする油によって様々に異なり得る。例えば、1〜10% C6、30〜60% C8、30〜60% C10、1〜10% C12を含むMCTsは、一般にパーム油及びココナツ油から誘導される。R、R’、及びR”の約95%超がC8であるMCTsは、オクタン酸によりグリセリンを半合成的にエステル化することにより調製され得る。C8の合計が約50%であり、及び/又はC10の合計が約50%であるMCTsを含む混合物も使用できる。前述のMCTs組成物は、市販品も入手可能であり、当業者に既知である。このようなMCTsは、本明細書において使用される用語MCTsと同様に振る舞い、かかる用語に包含される。
[0040]一態様では、本発明は、動物の移動能力及び/又は動作能力を高めるのに、並びにフレイルを予防及び/又は治療するのに好適な方法及び組成物を提供する。本発明者らは、MCTsを含む組成物が、動物の移動能力及び/又は動作能力を高めるのに、並びにフレイルを予防又は治療するのに有効であり得ることを発見している。そのため、動物の移動能力又は動作能力を向上させるための方法、あるいは動物においてフレイルを予防又は治療するための方法は、移動能力若しくは動作能力が低下している動物又はフレイルを有する若しくはフレイルになるリスクのある動物を識別することと、動物の移動能力若しくは動作能力を高めるにあたり又は動物のフレイルを予防又は治療するにあたり治療的に有効な量で、1種以上の中鎖トリグリセリド類(MCTs)を含む組成物を動物に投与することと、を含み得る。更に、動物の移動能力又は動作能力を高めるのに好適なペットフード組成物は、約15%〜約50%のタンパク質、約5%〜約40%の脂質、約5%〜約50%の炭水化物、及び約1%〜約40%の一種以上の中鎖トリグリセリド類(MCTs)を含み得る。組成物の含水率は、約5%〜約20%であり、MCTsは、動物の移動能力若しくは動作能力を高めるのに、あるいは動物のフレイルを予防又は治療するにあたり治療的に有効な量で存在させることができる。
[式中、R、R’及びR”は、グリセロール鎖に対しエステル化されており、それぞれ独立して6〜12個の炭素原子を有する脂肪酸である]。一態様では、R、R’、及びR”のうちの約95%超は8個の炭素原子からなる炭素鎖長のものであり得る。別の態様では、残りのR、R’、及びR”は炭素原子が6個又は10個の脂肪酸であり得る。他の実施形態では、R、R’、及びR”のうち少なくとも約30、40、若しくは50%超はC8であってよく、及び/又はR、R’、及びR”のうち少なくとも約30、40、若しくは50%超はC10であってよい。一実施形態では、R、R’、及びR”のうち約50%はC8であってよく、R、R’、及びR”のうち約50%がC10であってよい。MCTsは、任意の好適な合成供給源又は天然供給源から得ることができる。MCTの天然の供給源の例としては、ココナツ及びココナツ油、パーム核及びパーム核油などの植物資源、並びに任意の様々な動物種に由来する乳などの動物資源が挙げられる。
[0077]7.9歳齢〜11.3歳齢(平均年齢=9.77歳齢)の9頭のビーグル犬の老犬を使用した。体重の維持された摂食量(Super-premium-like control without MCT)をもとに、それぞれの犬の維持エネルギー必要量(maintenance energy requirement)(MER)を求めた。試験期間中、犬にはベースラインMERの100%となるよう給餌した。犬には5日間対照食を給餌し、市販の活動計により日中活動量を記録した。次に、市販の活動計で日中活動量を記録しながら、犬に5.5% MCTsを4週間給餌した。日中活動量(午前6時から午後6時まで)、及び夜間活動量(午後6時から午前6時まで)として動作能力を求めた。表1は、対照及びMCT食の栄養素性の概略を示す。
[0079]7歳齢〜12歳齢の16匹の健康なネコについて、プレベースライン維持エネルギー必要量を求めた。ネコのボディコンディションスコア(BCS)は4〜7の間であった。全てのネコには対照食を給餌した(タンパク質:41.7%;脂質:20.5%;水分:6.91%;繊維:0.48%)。プレベースライン期間中に、各ネコの維持エネルギー必要量(MER)を評価した。MERの計算式は、以下のとおりのものであった:MER(kcal/日)=60x体重(kg)。
Claims (20)
- 動物において移動能力又は動作能力を向上させるか、あるいは動物におけるフレイルを治療するための方法であって、
移動能力若しくは動作能力が低下している動物又はフレイルを有する動物を識別することと、
前記動物の移動能力若しくは動作能力を高めるにあたり又は前記動物のフレイルを治療するにあたり治療的に有効な量で、1種以上の中鎖トリグリセリド類(MCTs)を含む組成物を前記動物に投与することと、を含む、方法。 - 前記動物がコンパニオンアニマルである、請求項1に記載の方法。
- 前記動物がネコ又はイヌである、請求項1に記載の方法。
- 前記動物が老齢動物である、請求項1に記載の方法。
- R、R’、及びR”のうちの約95%超が、鎖中に8個の炭素原子を有するものである、請求項5に記載の方法。
- 残りのR、R’、及びR”が、炭素原子が6個又は10個の脂肪酸である、請求項6に記載の方法。
- 前記MCTsが、ペットフード組成物の一部として投与される、請求項1に記載の方法。
- 前記MCTsが、前記動物の体重1kgあたり0.001g〜約50gの量で投与される、請求項1に記載の方法。
- 前記MCTsが、前記動物に対する既存のペットフード組成物の供与前に、前記既存のペットフード組成物に前記MCTsを添加することにより、前記動物に投与される、請求項1に記載の方法。
- 動物において移動能力又は動作能力を向上させるか、あるいは動物におけるフレイルを治療するのに好適な食品組成物であって、
約15%〜約50%のタンパク質と、
約5%〜約40%の脂質と、
約5%〜約50%の炭水化物と、
約1%〜約40%の1種以上の中鎖トリグリセリド類(MCTs)と、を含み、
前記組成物の含水率は、約5%〜約20%であり、前記MCTsが、前記動物の移動能力若しくは動作能力を高めるのに、あるいは前記動物のフレイルを治療するのに有効な量で存在する、食品組成物。 - R、R’、及びR”のうちの約95%超が、鎖中に8個の炭素原子を有するものである、請求項12に記載の食品組成物。
- 残りのR、R’、及びR”が、炭素原子が6個又は10個の脂肪酸である、請求項13に記載の食品組成物。
- ビタミンB類の1日あたりの推奨用量の約0.1〜40倍の量で1種以上のビタミンB類を更に含む、請求項11に記載の食品組成物。
- 前記1種以上のビタミンB類として、
ビタミンB1(チアミン)、B2(リボフラビン)、B3(別名P又はPP)(ニコチン酸及び/又はニコチンアミドを含むナイアシン)、B5(パントテン酸)、B6(ピリドキシン)、B7(別名H)(ビオチン)、B8(ミオイノシトール)、B9(別名M又はB−c)(葉酸)、B12(コバラミン)、又はこれらの塩類、複合体類、若しくはビタミンB活性を有すると認識されている、又は有することが判明している誘導体類のうちの少なくとも1種を含む、請求項15に記載の食品組成物。 - 抗酸化物質の1日あたりの推奨用量の約0.01〜25倍の量で1種以上の抗酸化物質を更に含む、請求項11に記載の食品組成物。
- 前記1種以上の抗酸化物質が、
ビタミンA、ビタミンC、ビタミンE、α−リポ酸、クロロフィル、グルタチオン、ユビキノール、補酵素Q10、カロテノイド、リコピン、フラボノイド、フェノール酸、ポリフェノール、ピクノジェロール、チェリー、ブラックベリー、イチゴ、ラズベリー、クロウベリー、ブルーベリー、ビルベリー/ワイルドブルーベリー、黒スグリ、ザクロの実、ブドウ、オレンジ、プラム、パイナップル、キウイフルーツ、グレープフルーツ、ケール、チリペッパー、赤キャベツ、コショウ、パセリ、アーティチョーク、芽キャベツ、ホウレンソウ、レモン、ショウガ、ニンニク、レッドビート、アンズ、プルーン、デーツ、ソラマメ、インゲン豆、ダイズ、ピーカン、クルミ、ヘーゼルナッツ、ピーナッツ、ひまわりの種、大麦、雑穀、オーツ麦、トウモロコシ、クローブ、桂皮、ローズマリー、オレガノ、イチョウ(Ginkgo biloba)、ウヤク、パパイヤ(carica papaya)、緑茶、赤ワイン、セレニウム、ブチルヒドロキシアニソール(BHA)、及びブチルヒドロキシトルエン(BHT)のうちの少なくとも1種を含む、請求項17に記載の食品組成物。 - 前記食品組成物が、完全かつ栄養バランスのとれたペットフードとして処方される、請求項11に記載の食品組成物。
- 前記食品組成物が、乾燥押出成型したペットフード、ペット用トリーツ、又はセミモイストペットフード組成物として処方される、請求項11に記載の食品組成物。
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WO2019125913A1 (en) * | 2017-12-20 | 2019-06-27 | Michael Guarnieri | Nutritional bolus for animals |
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