JP2017531043A - 抗発作治療のためのａ１９−１４４、ａ２−７３およびある特定の抗コリンエステラーゼ阻害剤、組成物および方法 - Google Patents

抗発作治療のためのａ１９−１４４、ａ２−７３およびある特定の抗コリンエステラーゼ阻害剤、組成物および方法 Download PDF

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JP2017531043A
JP2017531043A JP2017539524A JP2017539524A JP2017531043A JP 2017531043 A JP2017531043 A JP 2017531043A JP 2017539524 A JP2017539524 A JP 2017539524A JP 2017539524 A JP2017539524 A JP 2017539524A JP 2017531043 A JP2017531043 A JP 2017531043A
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therapeutically effective
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JP2017531043A5 (enExample
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クリストファー ユー． ミスリング，
クリストファー ユー． ミスリング，
キャメロン デュラント，
キャメロン デュラント，
Original Assignee
アナベックス ライフ サイエンシズ コーポレイション
アナベックス ライフ サイエンシズ コーポレイション
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/10—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/14—Radicals substituted by nitrogen atoms not forming part of a nitro radical

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2017539524A 2014-10-20 2015-10-19 抗発作治療のためのａ１９−１４４、ａ２−７３およびある特定の抗コリンエステラーゼ阻害剤、組成物および方法 Pending JP2017531043A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462065833P 2014-10-20 2014-10-20
US62/065,833 2014-10-20
PCT/US2015/056172 WO2016064711A1 (en) 2014-10-20 2015-10-19 A 19-144, a2-73 and certain anticholinesterase inhibitor compositions and method for anti-seizure therapy

Related Child Applications (1)

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JP2020111574A Division JP2020152738A (ja) 2014-10-20 2020-06-29 抗発作治療のためのａ１９−１４４、ａ２−７３およびある特定の抗コリンエステラーゼ阻害剤、組成物および方法

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JP2017531043A true JP2017531043A (ja) 2017-10-19
JP2017531043A5 JP2017531043A5 (enExample) 2018-11-22

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JP2017539524A Pending JP2017531043A (ja) 2014-10-20 2015-10-19 抗発作治療のためのａ１９−１４４、ａ２−７３およびある特定の抗コリンエステラーゼ阻害剤、組成物および方法
JP2020111574A Pending JP2020152738A (ja) 2014-10-20 2020-06-29 抗発作治療のためのａ１９−１４４、ａ２−７３およびある特定の抗コリンエステラーゼ阻害剤、組成物および方法

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US (4) US10441563B2 (enExample)
EP (1) EP3209289A4 (enExample)
JP (2) JP2017531043A (enExample)
CA (1) CA2964520C (enExample)
WO (1) WO2016064711A1 (enExample)

Cited By (1)

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JP2021504400A (ja) * 2017-11-28 2021-02-15 アナベックス ライフ サイエンス コーポレイション シグマ−１受容体アゴニスト収縮期血圧療法

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WO2018022848A1 (en) 2016-07-27 2018-02-01 Anavex Life Sciences Corp. A2-73 as a therapeutic for insomnia, anxiety, and agitation
CN112424600B9 (zh) 2018-05-18 2024-07-02 阿纳韦克斯生命科学公司 σ-1激动剂治疗的优化和受治疗者的筛选方法
EP3883546A1 (en) 2018-11-21 2021-09-29 Rosemont Pharmaceuticals Ltd Oral topiramate suspension formulations with extended shelf stability and enhanced bioavailability
US11194591B2 (en) 2019-01-23 2021-12-07 Salesforce.Com, Inc. Scalable software resource loader
US10802944B2 (en) 2019-01-23 2020-10-13 Salesforce.Com, Inc. Dynamically maintaining alarm thresholds for software application performance management
US10747551B2 (en) 2019-01-23 2020-08-18 Salesforce.Com, Inc. Software application optimization
US10922062B2 (en) 2019-04-15 2021-02-16 Salesforce.Com, Inc. Software application optimization
US10922095B2 (en) 2019-04-15 2021-02-16 Salesforce.Com, Inc. Software application performance regression analysis

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WO2008087458A2 (en) * 2007-01-17 2008-07-24 Alexandre Vamvakides NEW SIGMA(σ)-RECEPTOR LIGANDS WITH ANTI-APOPTOTIC AND/OR PRO-APOPTOTIC PROPERTIES OVER CELLULAR BIOCHEMICAL MECHANISMS, WITH NEUROPROTECTIVE, ANTI-CANCER, ANTI-METASTATIC AND ANTI-(CHRONIC) INFLAMMATORY ACTION
JP2009506069A (ja) * 2005-08-26 2009-02-12 ブレインセルス，インコーポレイティド ムスカリン性受容体調節による神経発生
JP2011507800A (ja) * 2007-12-26 2011-03-10 エーザイ・アール・アンド・ディー・マネジメント株式会社 癲癇、精神障害、または感覚器官の障害のためのａｍｐａ受容体アンタゴニスト
WO2013008044A1 (en) * 2011-07-08 2013-01-17 Anavex Life Sciences Corp. Synthesis of (+) and (-) 1 -(5,5-diphenyltetrahydrofuran-3- yl)-n,n-dimethylmethanamine, (+) and (-) 1-(2,2-diphenyltetrahydrofuran-3-yl)-n,n- dimethylmethanamine and (+) and (-) 1-(2,2- dffhenyltetrahydrofuran-3-yl)-n-metihylmethanamine
US20140296211A1 (en) * 2013-03-28 2014-10-02 Anavex Life Sciences Corp. Anavex2-73 and certain anticholinesterase inhibitors composition and method for neuroprotection

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US20060252745A1 (en) 2005-05-06 2006-11-09 Almeida Jose L D Methods of preparing pharmaceutical compositions comprising eslicarbazepine acetate and methods of use

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WO2008087458A2 (en) * 2007-01-17 2008-07-24 Alexandre Vamvakides NEW SIGMA(σ)-RECEPTOR LIGANDS WITH ANTI-APOPTOTIC AND/OR PRO-APOPTOTIC PROPERTIES OVER CELLULAR BIOCHEMICAL MECHANISMS, WITH NEUROPROTECTIVE, ANTI-CANCER, ANTI-METASTATIC AND ANTI-(CHRONIC) INFLAMMATORY ACTION
JP2011507800A (ja) * 2007-12-26 2011-03-10 エーザイ・アール・アンド・ディー・マネジメント株式会社 癲癇、精神障害、または感覚器官の障害のためのａｍｐａ受容体アンタゴニスト
WO2013008044A1 (en) * 2011-07-08 2013-01-17 Anavex Life Sciences Corp. Synthesis of (+) and (-) 1 -(5,5-diphenyltetrahydrofuran-3- yl)-n,n-dimethylmethanamine, (+) and (-) 1-(2,2-diphenyltetrahydrofuran-3-yl)-n,n- dimethylmethanamine and (+) and (-) 1-(2,2- dffhenyltetrahydrofuran-3-yl)-n-metihylmethanamine
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Publication number Priority date Publication date Assignee Title
JP2021504400A (ja) * 2017-11-28 2021-02-15 アナベックス ライフ サイエンス コーポレイション シグマ−１受容体アゴニスト収縮期血圧療法
JP7180673B2 (ja) 2017-11-28 2022-11-30 アナベックス ライフ サイエンス コーポレイション シグマ－１受容体アゴニスト収縮期血圧療法

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US20210046038A1 (en) 2021-02-18
US20180177756A1 (en) 2018-06-28
US20200038365A1 (en) 2020-02-06
WO2016064711A1 (en) 2016-04-28
US10441563B2 (en) 2019-10-15
EP3209289A4 (en) 2018-04-11
CA2964520C (en) 2023-09-26
CA2964520A1 (en) 2016-04-28
US10813907B2 (en) 2020-10-27
JP2020152738A (ja) 2020-09-24
US11690821B2 (en) 2023-07-04
US20230301961A1 (en) 2023-09-28
EP3209289A1 (en) 2017-08-30

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