JP2017528216A - Pixel array medical device and method - Google Patents

Abstract

Systems, apparatus and methods are described in which the apparatus comprises a housing containing a skull pet device. The skull pet device includes a skull pet array that includes skull pets arranged in a pattern. The sculpture can exit the housing to create an incision skin pixel at the target site. The housing is positioned and the sculpture array is exposed to the tissue at the target site. An incision skin pixel is generated if the target site is a donor site, and a skin defect is generated if the target site is a recipient site. An incision skin pixel is incorporated. [Selection] Figure 19B

Description

RELATED APPLICATION This application benefits from the priority of US Patent Application No. 62 / 044,060, filed Aug. 29, 2014.
This application enjoys the benefit of priority of US Patent Application No. 62 / 044,078, filed August 29, 2014.
This application enjoys the benefit of priority in US Patent Application No. 62 / 044,089, filed August 29, 2014.
This application enjoys the benefit of priority in US Patent Application No. 62 / 044,102 filed August 29, 2014.
This application is a continuation-in-part of US patent application Ser. No. 14 / 099,380 filed Dec. 6, 2013. US patent application Ser. No. 14 / 099,380 benefits from the priority of US patent application Ser. No. 61 / 734,313, filed Dec. 6, 2012.
This application is a continuation-in-part of US patent application Ser. No. 12 / 972,013 filed Dec. 17, 2010. US patent application Ser. No. 12 / 972,013 benefits from the priority of US patent application Ser. No. 61 / 288,141 filed Dec. 18, 2009.
This application is a continuation-in-part of US patent application Ser. No. 14 / 505,090 filed Oct. 2, 2014.

TECHNICAL FIELD Embodiments of the present specification relate to medical systems, devices or devices, and methods, and more particularly, to medical devices and methods applied to surgical management of burns, skin defects, and hair transplants.

  The aging process is most visually represented by the progression of dependent skin relaxation. This lifelong process begins as early as the 30s and then gradually worsens over decades. Previous studies have shown that part of the cause of skin-dependent elongation and aging-related relaxation is progressive dermal atrophy associated with reduced skin tension. When combined with the downward force of gravity, aging-related dermal atrophy will cause a two-dimensional stretch of the skin envelope. The clinical finding of this physical-tissue process is excessive skin relaxation. The most affected areas are the head, neck, upper arm, thigh, chest, lower abdomen, and knees. The most visible of all these areas is the head and neck. In this area, there is a pronounced “turkey gobbler” relaxation in the neck and “jowls” in the lower face, the cause of which is the dependence that undermines the skin aesthetic in these areas.

  Plastic surgery techniques have been developed to remove excess loose skin. These procedures must use long incisions. Often long incisions are hidden around the anatomical boundary. Such a boundary is, for example, between the ear and the scalp if wrinkles on the face, and below the breast if it is a chest uplift (breast fixation). However, in some areas of skin laxation, the tradeoff between improved aesthetics and more visible surgical incision is worse. For this reason, the surplus skin on the upper arm, patella, thigh, and buttocks is generally not removed due to the visibility of surgical scars.

  Due to the frequency of this aesthetic distortion and negative social impact, the development of “face lift” surgery has been underway. Other related plastic surgical techniques in different areas are abdominal surgery (abdomen), breast fixation (chest), and sagging upper arm (upper arm). The inherent adverse effects of these surgeries are the risk of postoperative pain and scars and surgical complications. Even though the aesthetic enhancement of these techniques is an acceptable tradeoff for the significant surgical incision required, considerable permanent scarring is always a part of these techniques. For this reason, plastic surgeons design these techniques to hide considerable scars around anatomical boundaries such as the hairline (face lift), lower breast (breast fixation) and inguinal groove (abdominal surgery) . However, many of these incisions are hidden away from the area of skin relaxation, thus limiting their effectiveness. Other areas of skin relaxation, such as above the patella (upper anterior), are not amenable to plastic surgical resection due to a bad tradeoff with more visible surgical scars.

  Recently, electromagnetic medical devices that generate an inverse thermal gradient (ie, Thermage) have attempted to tighten the skin without surgery and may or may not have been successful. At present, these electromagnetic devices are best used for patients with moderate amounts of skin relaxation. Due to the limitations of electromagnetic devices and the potential side effects of surgery, minimally invasive techniques are needed to avoid medical variability of surgically related scars and electromagnetic heating of the skin. For many patients with aging-related skin relaxation (neck and face, arms, armpits, thighs, knees, buttocks, abdomen, braline, chest droop), partial resection of excess skin is a significant part of conventional plastic surgery Can strengthen the segment.

  Even more prominent than aesthetic changes in the skin envelope is the surgical management of burns and other trauma-related skin defects. Severe burns are classified by the total amount of burnt body surface and the depth of thermal destruction. First and second degree burns are generally managed in a non-surgical manner with topical cream application and burn bandages. Deeper third-degree burns involve thermal destruction of the entire skin thickness. Surgical management of these severe injuries includes removal of burned scab tissue and application of split-skin grafts.

  Skin defects across the thickness are most often created by excision of burns, trauma and skin cancer, and can be closed with flap transfer or skin tissue transplantation using current commercial equipment. Both surgical approaches require uptake from the donor site. The use of flaps is further limited by the need to include a pedunculated blood supply and in most cases the need to close the donor site directly.

  The split-graft procedure requires the incorporation of transplanted tissue from the own skin, ie from the same patient, due to immunological limitations. Typically, a burn patient's donor site is selected from a non-burn area and a sheet of partial skin thickness is taken from that area. Around this approach is the creation of a partial thickness skin defect at the donor site. This defect in the donor site itself is similar to a deep second degree burn. Healing by re-epithelialization at this site is often painful and can take several days. In addition, a visible alteration of the donor site is produced that appears to be permanently thinner and bleached than the surrounding skin. For patients with burns over a significant surface area, skin graft incorporation may be limited by the availability of non-burn areas.

  For these reasons, there is a need for instruments and techniques for aesthetic surgical skin tightening in the rapidly expanding aesthetic market. There is a need for a system, device, device or technique that can repeatedly incorporate skin grafts from the same donor site while removing the alteration of the donor site.

INCORPORATION BY REFERENCE Each patent, each patent application, and / or each publication mentioned herein is hereby incorporated by reference in its entirety. The extent is the same as if each individual patent, patent application and / or publication was specifically and individually indicated to be incorporated by reference.

Fig. 3 shows a PAD kit placed at a target site under an embodiment. 2 is a cross-section of a scalp punch or device including a scalp array, under an embodiment. FIG. 3 is a partial cross-section of a scalp punch or device including a scalp array, under an embodiment. The adhesive film with the backing (adhesive substrate) contained in the PAD kit is shown under the embodiment. FIG. 2 shows an adhesive film (adhesive substrate) when used with a PAD kit frame and blade assembly under an embodiment. FIG. 4 illustrates skin pixel removal under an embodiment. FIG. 4 is a side view showing removing an incision skin pixel across a blade with a PAD kit, under an embodiment. FIG. 3 is an isometric view showing blade / pixel interaction during an approach using a PAD kit, under an embodiment. FIG. 3B is another view of the procedure using a PAD kit (excluding blades for clarity), according to an embodiment, with the cut-out and acquired skin pixels or plugs and non-resection prior to resection FIG. 5 shows both skin pixels or plugs. FIG. 2 is a side view of a portion of a pixel array, showing a sculpture held on an investing plate, under an embodiment. FIG. 6 is a side view of a portion of a pixel array under an alternative embodiment showing a sculpture held on an investing plate. It is a top view of a sculpture plate based on an embodiment. FIG. 3 is an enlarged view of a part of a sculpture plate under the embodiment. An example of a rotating pixel drum is shown under the embodiment. 1 illustrates an example of a rotating pixel drum assembled to a handle under an embodiment. Figure 3 shows a drum dermatome for use with a sculpture plate under an embodiment. Fig. 3 shows a drum dermatome placed on a sculpture plate under an embodiment. FIG. 4 is another view of a drum dermatome placed on a skull pet plate, under an embodiment. FIG. 3 is an isometric view of application of a drum dermatome (e.g., paget dermatome) to a sculpture plate, according to an embodiment, wherein the adhesive film is applied to the drum of the dermatome before rolling the drum over the investing plate. Applies to FIG. 3 is a side view of a portion of a drum dermatome, showing the position of the blade relative to the sculpture plate, under an embodiment. FIG. 3 is a side view of a portion of a drum dermatome, showing different positions of the blades relative to the sculpture plate, under embodiments. FIG. 5 is a side view of a drum dermatome with other positions of the blades relative to the sculpture plate, under embodiments. FIG. 3 is a side view of a drum dermatome with a cross-cutting blade clip, according to an embodiment, showing the crossing of skin pixels by the blade clip. It is a bottom view of the drum dermatome along a sculpture plate under an embodiment. 1 is a front view of a drum dermatome along a sculpture plate, under an embodiment. FIG. It is a rear view of the drum dermatome along a sculpture plate based on Embodiment. FIG. 3 shows an assembly diagram of a dermatome with a pixel-on-lay sleeve (POS) according to an embodiment. FIG. 3 shows an exploded view of a dermatome with a pixel-on-lay sleeve (POS), according to an embodiment. FIG. 3 shows a portion of a dermatome with a pixel-on-lay sleeve (POS) under an embodiment. FIG. 3 shows a slip-on PAD that slides on a paget drum dermatome under an embodiment. FIG. 3 shows an assembly view of a slip-on PAD installed on a paget drum dermatome, under an embodiment. FIG. 4 shows a slip-on PAD installed on a paget drum dermatome and used with a perforated template or guide plate, under an embodiment. Fig. 4 shows skin pixel uptake by a Paget Drum Dermatome and an installed slip-on PAD, under an embodiment. An example of a pixel drum dermatome applied to a target site on the skin surface under an embodiment is shown. FIG. 5 shows another view of a portion of a pixel drum dermatome being applied to a target site on the skin surface under an embodiment. FIG. 3 shows a side perspective view of a PAD assembly, under an embodiment. FIG. 3 shows a top perspective view of a scalpel device used with a PAD assembly, under an embodiment. FIG. 3 shows a bottom perspective view of a scalpel device used with a PAD assembly, under an embodiment. FIG. 3 shows a side view of a punch impact device including a vacuum component, under an embodiment. FIG. 3 shows a top view of an oscillating flat sculpture array and blade device, under an embodiment. FIG. 3 shows a bottom view of a vibrating flat sculpture array and blade device, under an embodiment. It is an enlarged view of a flat array when a sculpture array, a blade, an adhesive film, and an adhesive backer are assembled under the embodiment. FIG. 3 is an enlarged view of a flat array of scalpets with a feeder component, under an embodiment. FIG. 3 shows a cylindrically cut cadaveric dermal matrix that resembles a size-captured skin pixel implant under embodiments. Under embodiments, a drum array drug delivery device. 1 is a side view of a needle array drug delivery device, under an embodiment. FIG. FIG. 3 is an upper isometric view of a needle array drug delivery device, under an embodiment. FIG. 3 is a lower isometric view of a needle array drug delivery device, under an embodiment. The composition of human skin is shown. 2 shows the physiological cycle of hair growth. Under embodiments, uptake of donor hair follicles is shown. The preparation of the recipient site is shown under the embodiment. Fig. 4 shows the arrangement of incorporated hair plugs at a recipient site under an embodiment. FIG. 4 shows the arrangement of a perforated plate at the donor site of the occipital scalp under the embodiment. FIG. 6 shows the penetration depth of the skull pet into the skin when the skull pet is configured to penetrate the subcutaneous fat layer to obtain a hair follicle. Under embodiments, hair plug uptake using a perforated plate at the occipital donor site is shown. FIG. 6 shows the generation of a visible hairline under the embodiment. FIG. 4 illustrates the preparation of a donor site for generating identical skin defects at a recipient site using a patterned perforated plate and a spring-loaded pixelation device under an embodiment. FIG. 4 illustrates implantation of an incorporated plug by inserting the incorporated plug into a corresponding skin defect created at the recipient site, under an embodiment. FIG. 3 illustrates a clinical endpoint using a pixel dermatome instrument and technique, under embodiments. It is the image of the skin by which engraving was performed to the corner | angular part and intermediate | middle point of the area | region of excision under embodiment. FIG. 6 is an image of a postoperative skin resection field under an embodiment. FIG. FIG. 6 is an image after 11 days from surgery, showing the primary healing with a measured margin, under the embodiment. FIG. 6 is an image 29 days after surgery, showing the primary healing of the ablation and the primary maturation of the ablation field continuing, with the measured margin, under the embodiment. FIG. 4 is an image after 29 days of surgery under the embodiment, showing the ablation primarily heals and the primary maturation of the ablation field continues with measured lateral dimensions. FIG. 7 is an image after 90 days post-operatively, with the measured lateral dimension showing that the ablation is primarily cured and the primary maturation of the ablation field continues, according to an embodiment.

  The embodiments described herein satisfy the rapidly expanding aesthetic market for devices and techniques for aesthetic surgical skin tightening. In addition, embodiments allow for the repeated incorporation of skin grafts from the same donor site while removing the alteration of the donor site. The embodiments described herein are configured to excise excess loose skin without leaving a visible scar. In this case, all areas of excessive skin relaxation can be excised with the pixel array dermatome, and the technique can also be performed in areas previously prohibited for the visibility of surgical incisions. The technical effects achieved through the embodiments described herein include smooth and tightened skin without visible or long scars along the anatomical boundary.

  Embodiments described in detail herein include pixel skin tissue transplantation devices and methods configured to provide the ability to repeatedly capture split-skin grafts without leaving a visible scar at the donor site. Is done. During the procedure, a pixel array dermatome (PAD) is used to capture skin grafts from selected donor sites. During the capture operation, the pixelated skin graft is placed on a semi-porous flexible adhesive film. The incorporated skin graft / membrane hybrid is then applied directly to the recipient's skin defect site. Partially excised donor sites are closed by applying an adhesive sheet or bandage (eg, Flexzan® sheeting, etc.) that functions as a large butterfly dressing for a given period of time (eg, a week) . Closing the intradermal skin defect generated by PAD accelerates the primary healing process. In the process, the normal epidermis-dermis architecture is reorganized in an anatomical manner to minimize scarring. As occurs after the operation, the adhesive film is desquamated (dropped) together with the stratum corneum of the transplanted tissue. The membrane can then be removed from the recipient bed without disturbing the transplanted tissue.

  Many of the effects achieved by pixel skin tissue transplantation techniques are worthy of explanation. Since the skin graft is pixelated, it can provide a drainage gap between the skin plug components, thereby increasing the "takes" rate compared to the sheet skin graft. In the first week after surgery, skin grafts “takes” at the recipient site by the process of angiogenesis. There, new blood vessels from the skin defect recipient bed grow in the new skin graft. The semi-porous membrane guides the leachate to the bandage.

  The flexible membrane is configured with elastic recoil characteristics. Its properties promote the juxtaposition of component skin plugs within the graft / membrane hybrid, promote primary adjacent healing of the skin graft plug, and convert the skin graft's pixelated appearance into a more uniform sheet form Is done. Furthermore, the membrane aligns the microarchitectural component skin plug so that the dermis is aligned with the dermis and the epidermis is aligned with the epidermis, thus facilitating a primary healing process that reduces scarring.

  The dermatome detailed herein has many major clinical applications. Partial skin excision for skin tightening, partial hair transplantation for alopecia, and partial skin uptake for skin transplantation. The partial skin excision of an embodiment includes capturing a skin plug using an adhesive membrane, but a partially dissected skin plug can be removed without capturing. The paradigm of incision, removal and closure best describes the clinical application of skin tightening. The embodiments described herein are configured to facilitate incision and removal. Embodiments also include a novel means of incising the skin surface to provide a larger sculpture array with multiple sculptures.

  A pixel array medical system, apparatus or device, and method for skin transplantation, skin resection, and hair transplantation are described. In the following description, numerous specific details are introduced to provide a thorough understanding of the embodiments of the specification and a description to enable it. However, one of ordinary skill in the art will recognize that these embodiments may be practiced without one or more of the specific details, or with other components, systems, and the like. In other instances, well-known structures and operations are not shown or described in detail to avoid obscuring aspects of the disclosed embodiments.

  The following terms are intended to have the following general meaning as they are used herein. However, the terms are not limited to the meanings described herein. This is because the meaning of any term may include other meanings when understood or applied by those skilled in the art.

  As used herein, “first degree burn” includes superficial burns that do not destroy the dermis from the epidermis. The first burn is visible as erythema (redness) of the skin.

  As used herein, “second degree burn” includes relatively deep burns in which the epidermis is destroyed from the epidermis and the epidermis is denatured by variable thickness. Most second-degree burns are accompanied by blister formation. Deep second-degree burns can usually turn into third-degree burns of the entire thickness due to oxidation and infection.

  As used herein, “third degree burn” includes burns involving thermal destruction throughout the thickness of the skin, including the dermis and epidermis. Third-degree burns may involve thermal destruction of deeper underlying tissues (subcutaneous and muscle layers).

  “Ablation” as used herein includes removal of tissue by destruction of the tissue, for example, heat removal of skin lesions with a laser.

  As used herein, “autograft” includes transplants taken from the same patient.

  As used herein, “Backed Adherent Membrane” includes an elastic adhesive membrane that obtains a crossed skin plug. The supported adhesive film of the embodiment is supported on the outer surface to maintain the alignment of the skin plugs during uptake. After the incorporation of the skin plug, the backing is removed from the adhesive film with the incorporated skin plug. The membrane of the embodiment is porous to allow drainage when placed at the recipient site. The membrane of the embodiment has elastic recoil characteristics. Thereby, when the backing is removed, it causes the sides of the skin plugs to approach each other and promotes healing as a sheet graft tissue at the recipient site.

  As used herein, “burn scar contraction” includes the tightening of scar tissue that occurs during the wound healing process. This process is more likely to occur with untreated third-degree burns.

  As used herein, “burn scar contracture” includes a band of scar tissue that restricts the range of motion of the joint or distorts the appearance of the patient, ie, facial burn scar contracture.

  As used herein, a “dermatome” includes a device that “cuts the skin” or captures a sheet-like layered graft. Examples of drum dermatomes include Padgett and Reese dermatomes. The electric dermatome is an electrical version of the Zimmer dermatome and paget dermatome.

  As used herein, “dermis” is the primary structural support and includes the deep layers of the skin that contain primarily non-cellular collagen fibers. Fibroblasts are cells in the dermis that produce collagen protein fibers.

  As used herein, “donor site” includes anatomical sites from which skin grafts are taken up.

  As used herein, “Epidermis” includes the outer layer of skin comprising viable epidermal cells and a non-viable stratum corneum that acts as a biological barrier.

  As used herein, “excise” includes surgical removal of tissue.

  As used herein, “Excisional Skin Defect” refers to a partial thickness defect or more typically a full thickness defect caused by surgical removal (resect / cut) of the skin (lesion). Including.

  As used herein, “FTSG” includes full thickness skin grafts where the full thickness of the skin is incorporated. With the exception of instruments as described herein, the donor site is closed as a surgical incision. For this reason, FTSG is limited to the surface area that can be taken.

  As used herein, “granulation tissue” includes highly angiogenic tissue that grows in response to a lack of skin in a full thickness skin defect. Granulation tissue is an ideal base in skin transplant recipient sites.

  As used herein, “Healing by primary intention” includes a wound healing process in which the normal anatomical configuration is reorganized with minimal scar tissue formation. Formally, scars are unlikely to be visible.

  As used herein, “Healing by secondary intention” refers to a more coherent form of healing in which the normal anatomical composition is poorly aligned and more scar collagen is produced. Including no wound healing process. Formally, scars tend to be visible.

  As used herein, “homograft” includes transplanted tissue that is taken from a different person and applied as a temporary biological bandage to a patient's recipient site. Many allografts are taken up as cadaver skin. Temporary “takes” of allogeneic transplantation can be partially achieved by immunosuppression, but allotransplantation is eventually replaced by autologous transplantation if the patient survives.

  As used herein, “incise” includes making a surgical incision without removing tissue.

  As used herein, “Mesh Split Thickness Skin Graft” is a split skin graft whose surface has been expanded by repeatedly incising a skin graft tissue captured by a device called a “mesher”. including. Mesh split grafts have a higher “take” ratio than sheet-like grafts. This is because mesh layered grafts allow drainage through the transplanted tissue and better match the irregularities of the contours of the recipient site. However, it produces an ugly reticulated implant appearance at the recipient site.

  “PAD” as used herein includes a pixel array dermatome, which is a class of equipment for partial skin ablation.

  As used herein, a “PAD kit” includes a disposable single use procedure kit comprising a perforated guide plate, a sculpture stamper, a guide plate frame, a supported adhesive film, and a transverse blade. .

  As used herein, a “perforated guide plate” includes a perforated plate that includes the entire implantation uptake area, where the holes in the guide plate are aligned with a stamper with handle or a slip-on PAD scalpet. The plate also functions as a guard to prevent unintentional laceration of the adjacent skin. The multiple holes of the guide plate may be round, oval, square, rectangular and / or triangular, etc., but may be of different shapes, but not limited thereto.

  “Pixelized full-thickness skin graft” as used herein is a full-thickness skin graft captured by the device described herein with no reduced, well-visible scar at the donor site Including full thickness skin grafts. The transplant will have an improved appearance at the recipient site, similar to the sheet-like FTSG, but will better fit the recipient site and have a higher percentage of “take” due to drainage gaps between the skin plugs. Another significant advantage of pixelated FTSG compared to sheet-like FTSG is the ability to implant a wider surface that would otherwise require STSG. This advantage is due to the ability to be taken while reducing visible scars from multiple donor sites.

  As used herein, “Pixelated Graft Harvest” includes skin grafts taken from a donor site with the devices detailed herein.

  As used herein, “pixelated split skin graft” includes partial layer skin grafts captured by an SRG device. Skin grafts share the advantages of mesh skin grafts without ugly donor sites or ugly recipient sites.

  As used herein, “recipient site” includes a skin defect site to which a skin graft is applied.

  As used herein, “resect” includes excision.

  As used herein, “scalpet” includes a single-edged knife that cuts through skin and soft tissue.

  As used herein, “scalpet” includes terms describing a small geometric shape (eg, circular, oval, rectangular, square, etc.) sculpt that cuts through a skin plug.

  As used herein, a “scalpet array” includes an array or array of multiple sculptures held on a substrate (eg, a base plate, stamper, stamper with handle, end, disposable end, etc.).

  As used herein, a “scalpet stamper” includes the handle-equipped skull pet array instrument component of a PAD kit that cuts a skin plug through a perforated guide plate.

  As used herein, "scar" includes visually noticeable morphological malformations from irregular collagen tissue deposition following a wound or irregular collagen tissue deposition following a wound.

  As used herein, “sheet-like full-thickness skin graft” includes what refers to applying FTSG to a recipient site as a continuous sheet. The appearance of FTSG is superior to that of STSG, so it is mainly used for skin grafts in visually noticeable areas such as the face.

  As used herein, “sheet-like layered skin grafts” are continuous sheets and include partial layer skin grafts with typical donor site malformations.

  As used herein, a “skin defect” includes the lack of a full layer of skin that can include deeper structures such as subcutaneous fat layers and muscles. Skin defects can be caused by a variety of reasons, such as surgical removal of burns, trauma, or cancer and correction of congenital deformities.

  As used herein, a “skin pixel” includes a piece of skin comprising the epidermis and a split or full-thick dermis, cut out by a sculpture. The skin pixel may include a skin appendage such as a hair follicle with or without a subcutaneous fat cuff. Also includes skin plugs.

As used herein, a “skin plug” includes a round (or other geometric) skin piece with a epidermis and a split or full-thick dermis, cut out by a scalpet, Crossed by a cutting blade and obtained by an adhesive back membrane.
As used herein, “STSG” includes partial-layer skin grafts in which part of the dermis and epidermis are taken up by transplantation.

  As used herein, the “subcutaneous fat layer” includes a layer directly below the skin and mainly composed of fat cells called lipid cells. This layer serves as the main isolation layer from the environment.

  As used herein, a “crossing blade” is a horizontally positioned single-edged blade that is inserted into a slot in a perforated plate frame or attached to an outrigger arm of a drum dermatome, as detailed herein. Including. The crossing blade crosses the base of the incision skin plug.

  “Wound healing” as used herein includes essential biological processes that result from any type of wound, whether one or more of thermal, kinematic, and surgical.

  As used herein, “Xenograft” includes transplanted tissue taken from different species and applied as a temporary biological bandage to a patient's recipient site.

  Multiple embodiments of the pixel array medical system, apparatus or device, and method used are detailed herein. The systems, apparatus or devices, and methods described herein provide for sagging skin without visible scars through devices used in various surgeries, such as plastic surgery, for skin transplantation. Includes minimally invasive surgical approaches for tightening skin excision and additionally for hair transplantation. In certain embodiments, the device is a disposable device. Embodiments herein avoid the clinical variability of surgical-related scars and electromagnetic heating of the skin, and perform small-scale multi-pixel ablation of skin as a minimally invasive alternative to large-scale plastic surgical excision of skin . The embodiments herein may be used for hair transplantation and may be used on body parts that are prohibited plastic surgery for visibility of surgical scars. In addition, the approach allows skin grafting operations to be performed while reducing scars at the patient's donor site by taking a transcutaneous incision from the donor's tissue site and placing it at the recipient's skin defect site.

  For many patients with aging-related skin relaxation (such as, but not limited to, the neck and face, arms, axilla, thighs, knees, buttocks, abdomen, braline, chest drop), the minimally invasive pixels herein The array medical device and method perform pixelated crossing / cutting of excess skin, replacing plastic surgery with scarring. In general, the techniques described herein are performed in an office setting under local anesthesia to minimize perioperative discomfort, but are not limited thereto. Only a short recovery period is required compared to the long healing phase from plastic surgery. Preferably, bandages and support garments wrapped around the treatment area are applied for a pre-specified period (eg, 5 days, 7 days, etc.). There is no or minimal pain associated with this technique.

  Relatively small skin defects (eg, in the range of about 0.5 mm to 4.0 mm) produced by the devices described herein are closed by applying an adhesive Flexan® sheet. The Flexan® sheet functions as a large butterfly bandage and may be pulled in an orientation (“vector”) that maximizes aesthetic contouring of the treatment area. A compressible elastic garment may be applied over the bandage to further aid in aesthetic contouring. After completion of the initial healing phase, a large number of small linear scars within the treatment area will have reduced visibility compared to a larger plastic surgical incision in the same area. Due to the delayed wound healing response, additional skin tightening is likely to occur over several months. Other potential applications of the embodiments described herein include hair transplantation, treatment of alopecia, treatment of snoring / sleep apnea, orthopedic / physical therapy, vaginal tightening, Treatment of female urinary incontinence and gastrointestinal sphincter tightening.

  Severe burns are classified by the total amount of burnt body surface and the depth of thermal destruction. The method used to manage these burns is highly dependent on this classification. First and second degree burns are usually managed in a non-surgical manner with topical cream application and burn bandages. Deeper third-degree burns include full-thickness thermal destruction of the skin, producing full-thickness skin defects. Surgical management of this severe injury usually involves removing the scab from burns and applying a split-skin graft.

  Skin defects throughout the thickness are often generated by excision of burns, trauma, or skin cancer and can be closed with flap transfer or skin tissue transplantation using conventional commercial equipment. Both surgical approaches require uptake from the donor site. The use of flaps is further limited by the need to include a pedunculated blood supply and in most cases the need to close the donor site directly.

  The split skin graft technique requires the incorporation of autologous skin grafts from the same patient due to immunological limitations. Typically, a burn patient's donor site is selected from a non-burn area and a sheet of partial skin thickness is taken from that area. Around this approach is the creation of a partial thickness skin defect at the donor site. This defect in the donor site itself is similar to a deep second degree burn. Healing by re-epithelialization at this site is often painful and can take several days. In addition, a visible alteration of the donor site that appears to be permanently thinner and bleached than the surrounding skin is often produced. For patients with burns over a significant surface area, skin graft incorporation may be limited by the availability of non-burn areas.

  Both conventional surgical approaches for closing skin defects (skin transfer and skin transplantation) involve not only significant scarring of the skin defect recipient site, but also a donor site from which the graft tissue is incorporated. In contrast to conventional techniques, the embodiments described herein include pixel skin graft techniques, also referred to as pixel array techniques. It removes this donor site deformation and provides a method for re-uptake of skin graft tissue from any existing donor site, including either sheet-like donor sites or pixelated donor sites. This ability to re-uptake skin grafts from existing donor sites reduces the surface area requirements for donor site skin and also provides additional skin in severely burned patients with limited burn donor surface area Provides transplantability.

  The pixel skin grafting technique of the embodiment is used as a full-thickness skin grafting. Many clinical applications, such as facial skin transplants and hand surgery and treatment of congenital deformities, are best performed with full-thickness skin transplants. The texture, color and overall morphology of full thickness skin grafts will be closer to the skin next to the defect than split skin grafts. For this reason, full-thickness skin grafts in visually conspicuous areas have an appearance advantage over split-skin grafts. The main drawback of full-thickness skin grafts under conventional techniques is the long linear scar generated from surgical sutures of full-thickness donor site defects. This scar limits the size and availability of full thickness skin grafts.

  In comparison, full-thickness skin grafting of the pixel skin grafting technique described herein is less restrictive on its size and availability because the linear scar at the donor site is removed. Thus, many skin defects that are usually covered with split-skin skin grafts will instead be treated with pixelated full-thickness skin grafts.

  Pixel skin grafting techniques provide the ability to incorporate split and full thickness skin grafts while minimizing visible scars at the donor site. During the procedure, a pixel array dermatome (PAD) device is used to capture skin grafts from selected donor sites. During the capture operation, the pixelated skin graft is placed on the adhesive film. Although the adhesive film of embodiment contains a semi-porous flexible adhesive film, it is not limited to this. The incorporated skin graft / membrane hybrid is then applied directly to the recipient's skin defect site. The partially excised donor site is closed by applying an adhesive Flexzan® sheeting that functions as a large butterfly dressing for a week. Closing a relatively small (eg, 1.5 mm) intradermal circular skin defect facilitates the primary healing process. In the process, the normal epidermis-dermis architecture is reorganized in an anatomical manner to minimize scarring. As it occurs about one week after the operation, the adhesive film is desquamated (collapsed) with the stratum corneum of the transplanted tissue. The membrane can then be removed from the recipient bed without disturbing the transplanted tissue. Thus, donor site healing occurs rapidly with minimal discomfort and scarring.

  Since the skin graft at the recipient defect site using the pixel skin graft technique is pixelated, it provides a drainage gap between the skin pixel components, thereby “takes” compared to the sheet skin graft. ) "Can be increased. In the first week (approximately) after surgery, the skin graft tissue “takes” at the recipient site by the process of angiogenesis. There, new blood vessels from the skin defect recipient bed grow in the new skin graft. The semi-porous membrane guides the leachate (fluid) to the bandage. Furthermore, the flexible membrane is designed with an elastic recoil characteristic. Its properties promote the juxtaposition of component skin pixels within the graft / membrane hybrid, promote primary adjacent healing of the skin graft pixels, and transform the skin appearance of the skin graft into a uniform sheet form. The In addition, the membrane aligns the microarchitectural component skin pixels so that the dermis is aligned with the dermis and the epidermis is aligned with the epidermis, thus facilitating a primary healing process that reduces scarring. In addition, pixelated skin grafts are more easily adapted to irregular recipient sites.

  The embodiments described herein include a pixel skin ablation technique, also referred to as a pixel technique. For many patients with aging-related skin relaxation (neck and face, arms, armpits, thighs, knees, buttocks, abdomen, braline, chest drop, etc.), partial resection of excess skin is a plastic surgery that causes scarring. Replace a considerable segment of. In general, the pixel technique is performed under local anesthesia in an office setting. The postoperative recovery period includes wearing support clothing for a number of days (eg, 5, 7, etc.) pre-designated in the treatment area (eg, 5 days, 7 days, etc.). It is expected that there will be no or relatively little pain associated with the technique. Small (eg 1.5 mm) circular skin defects are closed by applying an adhesive Flexan® sheet. The Flexan® sheet functions as a large butterfly bandage and is pulled in an orientation (“vector”) that maximizes aesthetic contouring of the treatment area. A compressible elastic garment may be applied over the bandage to further aid in aesthetic contouring.

  After completion of the initial healing phase, many small linear scars within the treatment area will not be visually noticeable. In addition, additional skin tightening will occur over a period of months due to the delayed wound healing response. The pixel approach is therefore a minimally invasive alternative to large scars in plastic surgery.

  The pixel array medical device of the embodiment includes a PAD kit. FIG. 1 shows a PAD kit placed at a target site under an embodiment. The PAD kit includes a flat perforated guide plate (guide plate), a sculpture punch or device containing a sculpture array (FIGS. 1-3), a supported adhesive film or substrate (FIG. 4), and a skin pixel crossing. A blade and (FIG. 5), but not limited thereto. The skull pet punch of the embodiment is a device that can be held by hand, but is not limited thereto. In an alternative embodiment, the guide plate is optional. This is detailed herein.

  FIG. 2 is a cross-sectional view of a PAD kit sculpture punch including a sculpture array according to an embodiment. The skull pet array includes one or more skull pets. FIG. 3 is a partial cross-section of a PAD kit sculpture punch including a sculpture array according to an embodiment. Although the partial cross section shows that the total length of the sculpture of the sculpture array is determined by the thickness of the perforated guide plate and the incision depth into the skin, the embodiment is not limited thereto.

  FIG. 4 shows an adhesive film with a backing (adhesive substrate) included in the PAD kit under the embodiment. The lower surface of the adhesive film is applied to the incision skin at the target site.

  FIG. 5 shows an adhesive film (adhesive substrate) when used with a PAD kit frame and blade assembly, under an embodiment. The top surface of the adhesive film is oriented with the adhesive side down in the frame and pressed onto the perforated plate to obtain extruded skin pixels (also referred to herein as plugs or skin plugs). .

  Referring to FIG. 1, during the procedure using the PAD kit, a perforated guide plate is applied to the skin ablation / donor site. A scalp punch is applied through at least a collection of holes in the perforated guide plate to cut through the skin pixels.

  If the punch sculpture array contains fewer sculptures than the total number of holes in the guide plate, the sculpture punches are applied multiple times to multiple sets of holes. After one or more successive applications of the scalp punch, the incision skin pixel or plug is captured on the adhesive substrate. The adhesive substrate is applied to capture the skin pixels or plugs from which the adhesive has been extruded. For example, the top surface of the adhesive substrate of the embodiment is oriented within the frame (if a frame is used) with the adhesive side down and pressed onto the perforated plate to capture the extruded skin pixels or plugs It is done. As the membrane is lifted, the captured skin pixels are traversed at its base by a traversing blade.

  FIG. 6 illustrates skin pixel removal under an embodiment. The adhesive substrate is lifted from the target site and pulled back (separated). This action floats or pulls the incision skin pixel or plug. While the adhesive substrate is being lifted, a transverse blade is used to traverse the base of the incision skin pixel. FIG. 7 is a side view showing removing an incision skin pixel across a blade with a PAD kit, under an embodiment. Crossing the skin pixel or plug base completes pixel capture. FIG. 8 is an isometric view showing blade / pixel interaction during an approach using a PAD kit, under an embodiment. FIG. 9 is another view of the procedure using the PAD kit (excluding the blade for clarity), according to the embodiment, with the cut-in and acquired skin pixels or plugs and cut-outs. FIG. 5 shows both a previous non-resected skin pixel or plug. At the donor site, the pixelated skin ablation site is closed by applying Flexan® sheeting.

  Guide plates and scalp devices are also used to generate skin defects at recipient sites. The skin defect is configured to accept skin pixels captured or captured at the donor site. The guide plate used at the recipient site may be the same as the guide plate used at the donor site, or may be different with different patterns or hole configurations.

  Skin pixels or plugs placed on the adhesive substrate during traversal are then transferred to a skin defect site (recipient site). They are applied as pixelated skin grafts at the recipient skin defect site. The adhesive substrate has an elastic recoil characteristic, which allows a closer alignment of skin pixels or plugs within the skin graft. The incision skin pixel can be applied directly from the adhesive substrate to the skin defect at the recipient site. Application of the incision skin pixel at the recipient site includes aligning the incision skin pixel with the skin defect and inserting the incision skin pixel into the corresponding skin defect at the recipient site.

  The pixel array medical device of the embodiment includes a pixel array dermatome (PAD). The PAD comprises a flat array of relatively small circular sculptures that are held on a substrate (eg, an investing plate). A scalpet combined with a substrate is referred to herein as a scalpet array, a pixel array, or a scalpet plate. FIG. 10A is a side view of a portion of a pixel array, showing a sculpture held on an investing plate, under an embodiment. FIG. 10B is a side view of a portion of a pixel array according to an alternative embodiment, showing a sculpture held on an investing plate. FIG. 10C is a top view of the sculpture plate according to the embodiment.

  FIG. 10D is an enlarged view of a portion of a sculpture plate under an embodiment. Scalpet plates are applied directly to the skin surface. The one or more skull pets of the skull pet array include one or more of a pointed surface, a needle, and a needle including a plurality of tips.

  Embodiments of the pixel array medical device and method include using an intake pattern instead of a guide plate. The uptake pattern includes, but is not limited to, an indicator or marker on the skin surface of at least one of the donor site and the recipient site. The marker includes any compound that can be applied directly to the skin to mark an area of the skin. The intake pattern is placed at the donor site, and the device's sculpture array is aligned with or positioned accordingly with the intake pattern at the donor site. As described herein, skin pixels are dissected with a sculpture array at the donor site. The recipient site is prepared by placing an intake pattern at the recipient site. The uptake pattern used at the recipient site may be the same as the uptake pattern used at the donor site, or it may be different with different patterns or marker configurations. A skin defect is generated and an incision skin pixel is applied to the recipient site as described herein. Alternatively, the guide plate of the embodiment is used when the intake pattern is applied, but is not limited thereto.

  In order to leverage existing surgical instruments, the array of embodiments is used in conjunction with, or as a modification to, a drum dermatome, such as a paget dermatome or a leeds dermatome. The Paget Drum Dermatome, referred to herein, was originally developed by Dr. Earl Padget in the 1930s and continues to be widely used for skin transplantation by plastic surgeons around the world. Later, a Paget dermatome Leeds-type modification was developed to better calibrate the thickness of incorporated skin grafts. The drum dermatome according to the embodiment is disposable (every operation), but is not limited thereto.

  In general, FIG. 11A shows an example of a rotating pixel drum 100 under an embodiment. FIG. 11B shows an example of a rotating pixel drum 100 assembled to a handle under an embodiment. More specifically, FIG. 11C shows a drum dermatome for use with a sculpture plate, under an embodiment.

  In general, as with all pixel devices described herein, the pixel drum 100 can have a variety of shapes without limitation, such as circular, semi-circular, elliptical, square, flat, rectangular, and the like. . In one embodiment, the pixel drum 100 is supported by an accelerator / handle assembly 102 and rotates around a drum rotating component 104 that is moved, for example, by an electric motor. In some embodiments, the pixel drum 100 may be placed on a stand (not shown) when not in use. The stand may function as a charger for the electric rotating component of the drum or the electric component of the syringe plunger. In some embodiments, a vacuum (not shown) may be applied to the skin surface of the pixel drum 100, and an outrigger (not shown) may be provided for tracking and stability of the pixel drum 100.

  In one embodiment, the pixel drum 100 incorporates a sculpture array 106 on the surface of the drum 100, thereby providing a plurality of small (eg, 0.5-1. 5 mm) Create a circular incision. In certain embodiments, the boundary shape of the sculpture may be designed to reduce pinking (“trap door”) while creating a skin plug. The circumference of each skin plug can be extended by a sculpt to a semi-circular, oval or square skin plug in a non-limiting example instead of a circular skin plug. In certain embodiments, the length of the scalpet 106 may vary depending on the thickness of the skin area selected for skin grafting purposes by the surgeon, ie, the split or full layer.

  When the drum 100 is applied to the skin surface, a blade 108 provided inside the drum 100 traverses the base of each skin plug generated by the sculpture array. Inner blade 108 is connected to central drum accelerator / handle assembly 102 and / or connected to an outrigger attached to central accelerator assembly 102. In an alternative embodiment, the inner blade 108 is not connected to the drum accelerator assembly 102 and the skin incision base is traversed. In some embodiments, the inner blade 108 of the pixel drum 100 is manually oscillated or moved by an electric motor. Depending on the density of the circular sculpture on the drum, variable areas of the skin (eg, 20%, 30%, 40%, etc.) are traversed in the area of excess skin relaxation.

  In one embodiment, an additional pixel drum harvester 112 is provided within the drum 100 and incorporates a crossed / pixelated skin incision / plug (pixel graft tissue) from the tissue of the pixel donor to provide a pixel drum. The skin transplantation operation is performed by aligning on the adhesive films 110 arranged inside 100. A narrow space for the inner blade 108 is created between the sculpture array 106 and the adhesive film 110.

  In one embodiment, the blade 108 is provided outside the drum 100 and the sculpture array 106 where the base of the incision circular skin plug is traversed. In other embodiments, the outer blade 108 is connected to the drum accelerator assembly 102 when the skin incision base is traversed. In an alternative embodiment, the outer blade 108 is not connected to the drum accelerator assembly 102 when the skin incision base is traversed. The adhesive film 110 draws and aligns the crossed skin segment and is then placed on the patient's skin defect site. The blade 108 (whether internal or external) may be a windowed layer of blades aligned with the sculpture array 106, but is not limited thereto.

  The conformable adhesive film 110 of the embodiment is quasi-porous so that when a film with aligned transverse skin segments is extracted from the drum and applied as a skin graft, leaching at the recipient skin defect will occur. It becomes possible. The adhesive quasi-porous drum membrane 110 has an elastic recoil characteristic that allows crossed / pixelated skin plugs to be brought close together for implantation into a recipient's skin defect site. That is, the margins of each skin plug are brought closer together as a more uniform sheet after the adhesive film with the pixelated implant is extracted from the drum 100. Alternatively, the adhesive semi-porous drum membrane 110 can be expanded to cover a large surface area of the recipient's skin defect site. In an embodiment, a sheet of the adhesive backer 111 may be applied between the adhesive film 110 and the drum harvester 112. As detailed herein, the drum array of sculptures 106, blades 108 and adhesive film 110 may be assembled as a sleeve for an existing drum 100.

  The internal drum harvester 112 of the pixel drum 110 of the embodiment is disposable and replaceable. Limiting and / or controlling the use of disposable components can be achieved by means including, but not limited to, electronic, EPROM, mechanical, durable. The electronic and / or mechanical recording and / or limitation of the drum speed of the disposable drum may be electronically or mechanically recorded, controlled and / or limited with the usage time of the disposable drum.

  During the uptake of the drum dermatome approach, the PAD sculpture array is applied directly to the skin surface. A drum dermatome is placed on top of the sculpture array to place a load on the underlying skin surface in order to incise the skin pixels circumferentially. As the load continues to be applied, the incision skin pixels are pushed through the holes in the sculpture array and captured on the drum dermatome adhesive film. A dermatome cutting outrigger blade (placed on top of the sculpture array) traverses the base of the extruded skin pixel. The membrane and pixelated skin composite is then removed from the dermatome drum and applied directly to the recipient skin defect as a skin graft.

  Referring to FIG. 11C, an embodiment includes a drum dermatome for use with a sculpture plate, as described herein. More specifically, FIG. 12A shows a drum dermatome placed on a sculpture plate according to an embodiment. FIG. 12B is another view of a drum dermatome placed on a sculpture plate, under an embodiment. A drum dermatome cutting outrigger blade is placed over the sculpture array, where the extruded skin plug is traversed at its base.

  FIG. 13A is an isometric view of the application of a drum dermatome (e.g., paget dermatome) to a sculpture plate, according to an embodiment, wherein the adhesive film is rolled before the drum is rolled over the investing plate Applies to that drum of Dermatome. FIG. 13B is a side view of a portion of a drum dermatome, showing the position of the blade relative to the sculpture plate, under an embodiment. FIG. 13C is a side view of a portion of a drum dermatome, according to an embodiment, showing different positions of the blade relative to the sculpture plate. FIG. 13D is a side view of a drum dermatome with other positions of the blade relative to the sculpture plate, under an embodiment. FIG. 13E is a side view of a drum dermatome with a cross-cutting blade clip, according to an embodiment, showing the crossing of skin pixels with the blade clip. FIG. 13F is a bottom view of a drum dermatome along a sculpture plate, under an embodiment. FIG. 13G is a front view of a drum dermatome along a sculpture plate, under an embodiment. FIG. 13H is a rear view of a drum dermatome along a sculpture plate, under an embodiment.

  Depending on the clinical application, Drum dermatome disposable adhesive membranes can be used to place / place excised relaxed skin and to incorporate / align pixelated skin grafts.

  Embodiments described herein include a pixel-on-lay sleeve (POS) used with a dermatome, such as a paget dermatome or a leeds dermatome.

  FIG. 14A shows an assembled view of a dermatome with a pixel onlay sleeve (POS), under an embodiment. The POS comprises a dermatome and a blade, which are incorporated together with an adhesive backer, adhesive and a sculpture array. The adhesive backer, adhesive and sculpture array are integrated into the device, but are not limited to this.

  FIG. 14B shows an exploded view of a dermatome with a pixel onlay sleeve (POS), under an embodiment. FIG. 14C shows a portion of a dermatome with a pixel onlay sleeve (POS), under an embodiment.

  POS, also referred to herein as a “sleeve”, provides a disposable drum dermatome onlay for partial excision of excess relaxed skin and partial skin transplantation of skin defects. The onlay sleeve is used in conjunction with a Paget dermatome or a Leeds dermatome as a disposable component. The POS of the embodiment is a three-sided slip-on disposable sleeve that engages a drum dermatome. The device comprises an adhesive surface and a sculpture drum array with an internal transverse blade. The transverse blade of the embodiment includes a single-edged cutting surface that is swung across the inner peripheral surface of the sculpture drum array.

  In an alternative blade embodiment, the fenestrated cutting layer covers the inner peripheral surface of the sculpture array. Each window surface with a cut surface is aligned with each individual skull pet. Instead of rocking to traverse the base of the skin plug, the fenestrated cutting layer vibrates over the sculpture drum array. A narrow space for the passage of the blade is created between the adhesive surface and the sculpture array. An insertion slot for an additional adhesive film is provided for multiple captures during skin graft surgery. The protective layer on the adhesive film is peeled off in situ by the pulled pull tab. The tab is lifted from a pull slot on the opposite side of the sleeve assembly. As with other pixel device embodiments, the adhesive film is semi-porous for drainage at the recipient skin defect site. In order to transform the pixelated skin graft into a more continuous sheet, the membrane also has elastic recoil properties, thereby providing the skin plugs to be aligned closer together in the skin graft. Good.

  The embodiments described herein include a slip-on PAD configured as a disposable device with either a Paget dermatome or a Leeds dermatome. FIG. 15A shows a slip-on PAD that slides on a paget drum dermatome, under an embodiment. FIG. 15B shows an assembly view of a slip-on PAD installed on a paget drum dermatome, under an embodiment.

  The slip-on PAD of the embodiment is (optionally) used in combination with a perforated guide plate. FIG. 16A shows a slip-on PAD installed on a Paget drum dermatome and used with a perforated template or guide plate, under an embodiment. The porous guide plate is placed on the target skin site, and the orientation is maintained by being held in place by the adhesive on the lower surface of the apron. Paget dermatome with slip-on PAD rolls over the skin through a perforated guide plate.

  FIG. 16B illustrates skin pixel capture with a Paget Drum Dermatome and an installed slip-on PAD, under an embodiment. For skin pixel uptake, the slip-on PAD is removed, adhesive tape is applied over the paget dermatome drum, and a clip-on blade is attached to the dermatome outrigger arm, which blade then traverses the skin pixel base. Used for. The slip-on PAD of the embodiment is (optionally) used with standard surgical instruments such as ribbon retractors to protect the skin next to the donor site.

  The pixel instrument embodiments described herein include a pixel drum dermatome (PD2) that is a disposable instrument or device. PD2 includes a cylinder or rotating / rotating drum coupled with a handle, and the cylinder includes a sculpture drum array. The inner blade is connected to the drum shaft / handle assembly and / or to an outrigger attached to the central shaft. According to the PAD and POS described herein, multiple small pixelated excisions of the skin are made directly into the area of skin relaxation so that skin tightening can be enhanced while minimizing visible scars.

  FIG. 17A shows an example of a pixel drum dermatome being applied to a target site on the skin surface, under an embodiment. FIG. 17B shows another view of a portion of a pixel drum dermatome being applied to a target site on the skin surface, under an embodiment.

  The PD2 device applies the entire rotating / rotating drum to the skin surface. There, a plurality of small (eg, 1.5 mm) circular incisions are created at the target site by the “Scalpet Drum Array”. The base of each skin plug is then traversed by an internal blade. The inner blade is coupled to the central drum accelerator / handle assembly and / or to an outrigger attached to the central accelerator. Depending on the density of the circular skullpet on the drum, a variable percentage of the skin is traversed. Although PD2 makes it possible to cross part of the surface area of the skin (eg 20%, 30%, 40%, etc.) without leaving visible scars in the area of excessive skin relaxation, Is not limited to this.

  Another alternative embodiment of the pixel device shown herein is a pixel drum harvester (PDH). Similar to the pixel drum dermatome, the added internal drum takes the pixelated cross of the skin and places it on the adhesive film, which is placed over the patient's recipient skin defect site. The conformable adhesive membrane is semi-porous, which allows leaching of the recipient skin defect when the membrane with aligned ablated skin segments is extracted from the drum and applied as a skin graft. The elastic recoil characteristics of the membrane allow the pixelated skin segments to be closer together, thereby partially converting the pixelated skin graft into a sheet-like graft at the recipient site.

  The pixel array medical systems, instruments or devices, and methods described herein may cause or enable cellular and / or extracellular responses that are essential for the clinical outcome to be achieved. For pixel dermatomes, the physical contraction of the skin surface occurs due to pixelated ablation of the skin, i.e. the creation of skin plugs. In addition, subsequent skin tightening results from a delayed wound healing response. As detailed herein, each pixelated ablation initiates a mandatory wound healing sequence in multiple phases.

  The first phase of this sequence is the inflammatory phase, where degranulation of mast cells releases histamine into the “wound”. Histamine release causes dilation of the capillary bed and increases vascular permeability into the extracellular space. This initial wound healing response occurs within the first day and appears as erythema on the skin surface.

  The second phase (of fibrosis) begins within 3-4 days of the “wound”. During this phase there is fibroblast metastasis and mitotic growth. Wound fibrosis involves the deposition of new collagen and myofibroblastic contraction of the wound.

  Histologically, the deposition of new collagen can be identified microscopically as cell consolidation and thickening of the dermis. Although this is a static process, the wound tension increases considerably. Another component of fibroproliferation is that it is a dynamic physical process that causes multidimensional contraction of the wound. This component feature of fibroproliferation is due to active cellular contraction of myofibroblasts. Morphologically, the myoblastic contraction of the wound will be visualized as a two-dimensional tightening of the skin surface. Overall, the effect of fibroproliferation is dermal contraction with a reinforced framework due to the deposition of new collagen as a static support scaffold material. The clinical effect manifests as a delayed tightening of the skin with a smooth feel over several months. In general, the clinical endpoint is a skin envelope that looks more youthful in the treatment area.

  The third and final phase of the delayed wound healing response is maturity. During this phase, strengthening and remodeling of the treatment area occurs due to increased interlinkage of the (dermal) collagen fiber matrix. This final stage begins within 6 to 12 months after the “wound” and may last at least 1 to 2 years. Small pixelated excision of the skin preserves the normal dermal architecture during this delayed wound healing process, which does not involve the production of noticeable scars. The scar often occurs with surgical removal of larger skin. Finally, the release of epidermal growth hormone results in the associated stimulation and rejuvenation of the epidermis. A delayed wound healing response can be triggered with scar collagen deposition in tissues with minimal existing collagen matrix (such as muscle and fat).

  In addition to skin tightening for aesthetic purposes, the pixel array medical systems, devices or devices, and methods described herein have additional medical related applications. In certain embodiments, the pixel array device can traverse variable portions of any soft tissue structure without resorting to standard surgical excision. Specifically, reducing the actinic damage area of the skin via the pixel array device will reduce the incidence of skin cancer. For the treatment of sleep apnea syndrome and snoring, pixelated mucosal reduction (soft palate, base of tongue and pharyngeal sidewall) via a pixel array device will reduce the significant unhealth associated with more standard surgery. Let's go. For vaginal cap delivery trauma, pixelated skin and vaginal mucosal resection via a pixel array device will re-establish normal pre-partum shape and function without A & P resection. Related female stress urinary incontinence can also be corrected in a similar manner.

  A pixel array dermatome (PAD) of an embodiment, also referred to herein as a sculpture device assembly, includes a control device, also referred to as a punch impact handpiece, and a sculpture device, also referred to as an end device. including. The sculpture device is removably coupled to the control device and includes a sculpture array provided within the sculpture device. Although the removable skull pet device of the embodiment is disposable and is configured to be used during a single operation, the embodiment is not limited thereto.

  The PAD includes an apparatus with a housing configured to contain a scalpel device. The sculpture device includes a substrate and a sculpture array, and the sculpture array includes a plurality of sculptures arranged in a configuration on the substrate. The substrate and the plurality of scalpets are configured to exit and enter the housing, and the plurality of scalpets are configured to generate a plurality of incision skin pixels at the target site when exiting. The proximal end of the control device is configured to be hand held. The housing is configured to be removably coupled with a receiver that is a component of the control device. The control device includes a proximal end that includes a drive mechanism and a distal end that includes a receiver. The control device is configured to be disposable, but alternatively the control device is configured to perform at least one of cleaning, disinfection, and sterilization.

  The sculpture array is configured to exit in response to activation of the drive mechanism. The sculpture device of the embodiment is configured such that the sculpture array exits the sculpture device and enters the sculpture device in response to the activation of the drive mechanism. The alternative embodiment sculpture device is configured to cause the sculpture array to exit the sculpture device upon activation of the drive mechanism and back into the sculpture device upon release of the drive mechanism. .

  FIG. 18 shows a side perspective view of a PAD assembly, under an embodiment. The PAD assembly of the present embodiment includes a control device including a sculpture device including a sculpture array and an actuator or a trigger, which is configured to be handheld. Although the control device is reusable, an alternative embodiment includes a disposable control device. Embodiment scalpet arrays are configured to generate or create an incision array (eg, 1.5 mm, 2 mm, 3 mm, etc.), as detailed herein. Embodiments of the scalpet device include a spring-loaded scalpet array configured to incise the skin as detailed herein, although embodiments are not limited thereto.

  FIG. 19A shows a top perspective view of a sculpture device used with a PAD assembly, under an embodiment. FIG. 19B shows a bottom perspective view of a sculpture device used with a PAD assembly, under an embodiment. The sculpture device includes a housing configured to receive a substrate coupled to or including a plunger. The housing is configured such that the proximal end of the plunger protrudes from the top surface of the housing. The housing is configured to be removably coupled to the control device, and the length of the plunger is configured to protrude from the top surface by a distance that contacts the control device and actuator when the scalpet device is coupled to the control device. The

  The substrate of the sculpture device is configured to hold a number of sculptures forming a sculpture array. The sculpture array comprises a predesignated number of sculptures to be suitable for the procedure in which the sculpture device assembly is used. The sculpture device includes at least one spring mechanism that is configured to provide a downward or impact or punching force in response to activation of the sculpture array device. This force helps to create an incision (pixelated skin excision site) with a sculptpet array. Alternatively, the spring mechanism may be configured to provide an upward or retracting force to assist in retraction of the skullpet array.

  One or more of the skull pet device and the control device of the embodiment include an encryption system (e.g., EPROM). The encryption system is configured to prevent unauthorized use and piracy of the skull pet device and / or control device, but is not limited thereto.

  During surgery, the scalp device assembly is applied once to the target area, or alternatively, subsequently applied within the designated target treatment area of skin relaxation. As detailed herein, pixelated skin resection sites within the treatment area are then closed by applying Flexan sheeting, and these pixelated resection directional closures are used to treat aesthetic corrections of the treatment site. Done in a direction that provides maximization.

  An alternative embodiment PAD device includes a vacuum component or system for removing incision skin pixels. FIG. 20 shows a side view of a punch impact device including a vacuum component, under an embodiment. The PAD of this example includes, but is not limited to, a vacuum system or component within the control device for aspirating the incision skin pixel. The vacuum component is removably coupled to the PAD device and its use is optional. The vacuum component is configured or coupled to create a low pressure zone in or adjacent to one or more of the housing, the scalpel device, the scalpel array, and the control device. The low pressure zone is configured to remove the incision skin pixel.

  Another alternative embodiment PAD device includes a radio frequency (RF) component or system for generating skin pixels. The RF component is configured and coupled to provide energy to or couple to energy in or adjacent to one or more of the housing, the scalpel device, the scalpel array, and the control device. The RF component is removably coupled to the PAD device and its use is optional. The energy provided by the RF component includes one or more of thermal energy, vibration energy, rotational energy, acoustic energy, and the like.

  Yet another alternative embodiment PAD device includes a vacuum component or system and an RF component or system. The PAD of the present embodiment includes a vacuum system or component within the handpiece for aspirating and removing incision skin pixels. The vacuum component is removably coupled to the PAD device and its use is optional. The vacuum component is configured or coupled to create a low pressure zone in or adjacent to one or more of the housing, the scalpel device, the scalpel array, and the control device. The low pressure zone is configured to remove the incision skin pixel. In addition, the PAD device includes an RF component that provides or couples energy in or adjacent to one or more of the housing, sculpture device, sculpture array, and control device. Configured to be coupled to it. The RF component is removably coupled to the PAD device and its use is optional. The energy provided by the RF component includes one or more of thermal energy, vibration energy, rotational energy, acoustic energy, and the like.

  As a specific example, an embodiment PAD includes an electrosurgical generator configured to more effectively dissect a donor skin or skin plug while minimizing heat conduction damage to adjacent skin. Thus, for example, an RF generator operates using a relatively high power level with a relatively short duty cycle. The RF generator is configured to supply one or more of an electric impactor component, a cycling impactor, a vibration impactor, and an ultrasonic transducer configured to provide additional pressing force for cutting.

  As described herein, the PAD with RF in this example also includes a vacuum component. The vacuum component of the present embodiment applies a vacuum that pulls the skin toward the sculpt (eg, into the lumen of the sculpt), thereby creating an RF-mediated incision of the skin within the partial ablation field. Although configured to stabilize and promote, it is not so limited. One or more of the RF generator and the vacuum device are coupled to be under the control of a processor executing a software application. In addition, as described in detail herein, the PAD of the present embodiment can be used with a guide plate, but is not limited thereto.

  In addition to partial incision at the donor site, partial skin tissue transplantation involves the incorporation and placement (eg, on an adhesive film) of a skin plug for transfer to the recipient site. Similar to partial skin ablation, the use of a duty-driven RF cutting edge on the sculpture array makes it easier to cut the donor skin plug. The base of the incision sculpture is then traversed and incorporated as detailed herein.

  The timing of the vacuum assist component is controlled by the processor to provide a defined sequence with an RF duty cycle. Software control allows different variations to provide an optimal solution for the combined sequence of RF cutting and vacuum assist. Without limitation, these include the initial vacuum period prior to the RF duty cycle. Following the RF duty cycle, the time period in the sequence of embodiments includes aspiration acquisition of the incision skin plug.

  Other potential control sequences for PAD include, but are not limited to, simultaneous duty cycles of RF and vacuum assist. Alternatively, the control sequence of the embodiment may pulse or cycle the RF duty cycle within the sequence and / or with a change in RF power or with the use of a generator at a different RF frequency. Including.

  Other alternative control sequences include designated RF cycles that occur at the depth of the partial incision. With a low power, long duration RF duty cycle with an insulating shaft, the active cutting tip can create a thermally conductive injury at the deep interface between the dermis and subcutaneous tissue. Deep burns cause a delayed wound healing sequence and can tighten the skin secondarily without burning the skin surface.

  Software control allows different variations to provide an optimal solution for the combined sequence of RF cutting and electromechanical cutting and vacuum assist. Examples include, but are not limited to, electromechanical cutting with vacuum assist, RF cutting with electromechanical cutting and vacuum assist, RF cutting with vacuum assist, and RF cutting with vacuum assist. Examples of synthetic software controlled duty cycles include pre-cutting vacuum skin stabilization period, RF cutting duty cycle with vacuum skin stabilization period, RF cutting duty cycle with vacuum skin stabilization and electromechanical cutting period, Electromechanical cutting with a vacuum skin stabilization period and post-cutting RF duty cycle to heat conductively heat the deeper dermis layer and / or dermis tissue layer and cause a wound healing response for skin tightening; Including, but not limited to, a post-cut vacuum period for skin tightening.

  Other embodiments of the pixel array medical device described herein include a device comprising a oscillating flat array of scalpets and a powered or manual (non-powered) blade, which is described herein. Used for skin tightening as an alternative to the drum / cylinder described. FIG. 21A shows a top view of an oscillating flat sculpture array and blade device, under an embodiment. FIG. 21B shows a bottom view of an oscillating flat sculpture array and blade device, under an embodiment. The blade 108 may be a windowed layer of blade aligned with the sculpture array 106. The device handle 102 is separated from the blade handle 103, and the adhesive film 110 can be peeled off from the adhesive backer 111. FIG. 21C is an enlarged view of the flat array when the sculpture array 106, the blade 108, the adhesive film 110, and the adhesive backer 111 are assembled according to the embodiment. When assembled, a flat array of scalpets can be measured to provide uniform uptake or uniform ablation. In some embodiments, the flat array of scalpets may further include a feeder component 115 for the adhesive uptake membrane 110 and the adhesive backer 111. FIG. 21D is an enlarged view of a flat array of scalpets with a feeder component 115, under an embodiment.

  In other skin graft embodiments, the pixel graft is placed on an irradiated cadaver dermal matrix (not shown). When cultured on the dermal matrix, full-thickness skin grafts for patients immunologically identical to the pixel donor are generated. In an embodiment, the cadaver dermis matrix may be resected in a cylinder with a size similar to the captured skin pixel graft, in which case the pixelated graft is systematically aligned within the cadaver dermis framework. Can do. FIG. 22 shows a cylindrically cut cadaver dermis matrix that resembles a size-captured skin pixel graft under an embodiment. In certain embodiments, the rate of donor site uptake may be determined in part depending on the induction of normal dermal tissue at the recipient's skin defect site. That is, the normal (smooth) surface topology of the skin graft is promoted. According to the adhesive membrane embodiment or the dermal matrix embodiment, the pixel drum harvester has the ability to incorporate a large surface area for implantation while significantly reducing or eliminating visible scars at the patient's donor site. Including.

  In addition to the pixel array medical device described herein, embodiments include a drug delivery device. In most cases, parenteral administration of the drug is still accomplished by syringe and needle injection. To circumvent the negative features of needle and syringe systems, transdermal drug local absorption through an occlusive patch has been developed. However, both of these drug delivery systems have major drawbacks. Human aversion to needle injection has not softened during its nearly two-century period of use. Variable systemic absorption of subcutaneous or intramuscular drug injection reduces the efficacy of the drug and increases the likelihood of side effects on the patient. Depending on the drug liquid or aqueous carrier fluid, topically applied occlusive patches suffer from variations in absorption through the epidermal barrier. For patients who require local anesthesia across a large surface of the skin, neither syringe / needle injection nor surface anesthesia is ideal. Syringe / needle “field” injections are often painful and can inject an excessive amount of local anesthesia that can cause systemic toxicity.

  Surface anesthesia rarely provides the level of anesthesia necessary for skin related surgery.

  FIG. 23 is a drum array drug delivery device 200 according to an embodiment. The drug delivery device 200 has succeeded in solving the limitations and drawbacks of other drug delivery systems. The device comprises a drum / cylinder 202 that is supported by an accelerator / handle assembly 204 and rotates about a drum rotation component 206. The handle assembly 204 of the embodiment further includes a reservoir 208 of medication to be administered and a syringe plunger 210. The surface of the drum 202 is covered by a uniform length needle array 212. This makes it possible to make the intradermal (or subcutaneous) injection depth uniform while better controlling the amount of drug injected into the patient's skin. During the procedure, the syringe plunger 210 pushes the drug out of the reservoir 208 and the pushed drug is injected into the sealed injection chamber 214 in the drum 202 via the connection tube 216. When the needle array 212 is pressed against the patient's skin until the surface of the drum 202 hits the skin, the drug is ultimately administered to the patient's skin at a uniform depth. Non-anesthetic skip areas are avoided and a more uniform pattern of skin anesthesia is generated. The rotating drum application of the drug delivery device 200 can also inject local anesthesia faster while reducing patient discomfort.

  FIG. 24A is a side view of a needle array drug delivery device 300 according to an embodiment. FIG. 24B is an upper isometric view of the needle array drug delivery device 300, under an embodiment. FIG. 24C is a lower isometric view of the needle array drug delivery device 300, under an embodiment. The drug delivery device 300 comprises a flat array 312 of sharp needles of uniform length disposed on a manifold 310 and is used for drug administration. In this exemplary embodiment, the injectable drug is held in a syringe 302 that is plugged into a disposable adapter 306 with a handle. The seal 308 can be used to ensure that the syringe 302 and the disposable adapter 306 are firmly coupled together. When the syringe plunger 304 is pushed, the medicine held in the syringe 302 is conveyed from the syringe 302 to the disposable adapter 306. When the needle array 312 is pressed against the patient's skin until the manifold 202 hits the skin, the drug is further administered through the flat array 312 of sharp needles at a uniform depth into the patient's skin.

  Use of the drug delivery device 200 may have as many clinical applications as there are drugs that require percutaneous injection or absorption. As a non-limiting example, some potential applications include injection of local anesthesia, injection of neuromodulators such as botulinum toxin (botox), injection of insulin, and replacement of estrogen and corticosteroids ,including.

  In certain embodiments, the syringe plunger 210 of the drug delivery device 200 may be powered by an electric motor, as a non-limiting example. In certain embodiments, a fluid pump (not shown) attached to an infusion bag and tube may be connected to the infusion chamber 214 and / or reservoir 208 for continuous infusion. In certain embodiments, the volume of the syringe plunger 210 in the drug delivery device 200 may be calibrated and programmable.

  Another application of pixel skin graft capture with a PAD (pixel array dermatome) device detailed herein is alopecia. Alopecia is a common aesthetic disease that is common in middle-aged men but is also found in aged baby boomer women. The most common form of alopecia is androgenetic alopecia (MPB), which occurs in the area from the top of the scalp to the frontal region. Male pattern baldness is a gender-linked characteristic and is inherited in offspring by the X chromosome from the mother. For men, only one gene is needed to represent this trait. Since the gene is recessive, female pattern alopecia requires inheritance of both X-linked genes from both father and mother. Expression varies from patient to patient and is often expressed by age of onset and amount of frontal / partial / occipital hair loss. Variations in MPB phenotypic expression from patient to patient depend on the genotype translation variability of this gender-linked characteristic. Since MPB is inherited, the need for hair transplantation is enormous. Other non-genetic related etiologies are found in a more limited population segment. These non-genetic etiologies include trauma, bacterial infections, lupus erythematosus, radiation and anticancer drug treatment.

  Various treatment options have been proposed to the public. These include FDA approved coatings such as minoxidil and finasteride. These drugs have had limited success because they need to convert dormant hair follicles into the active growth phase. Other treatments include wigs and hair weaving. Conventional means are also surgical hair transplants, which involve transferring hair plugs, strips and flaps from a hairy scalp to a hairless scalp. Often, conventional hair transplantation involves transferring multiple single hair micrographs from a hairy scalp to the hairless scalp of the same patient. Alternatively, the donor plug is first captured as a hair strip and then divided into micrographs for transfer to the recipient scalp. In any case, this multi-step procedure is very expensive and involves hours of surgery on the average patient.

  The traditional hair transplant market has been hampered by long hair transplant procedures performed in several stages. A typical hair transplantation procedure involves the transfer of a hair plug from the bald scalp donor site to the bald scalp to frontal scalp recipient site. For many procedures, each hair plug is individually transferred to the recipient scalp. During the surgery, hundreds of plugs are implanted and this takes hours to do. The post-operative “take” or survival rate of the implanted hair plug is variable depending on factors that limit angiogenesis at the recipient site. Exercise bleeding and mechanical damage are key factors that reduce angiogenesis and “take” of hair transplant tissue.

  Embodiments described herein include a surgical instrument configured to transfer several hair grafts at once, which are held together and aligned at a scalp recipient site. To do. The technique described in this specification using the PAD of the embodiment reduces the annoyance and time required by conventional instruments.

  FIG. 25 shows the structure of the human skin. The skin contains two horizontal layers called the dermis and epidermis and acts as a biological barrier to the external environment. The epidermis is an envelope layer and includes a layer capable of growing epidermal cells. Epidermal cells migrate upward and “mature” into a non-viable layer called the stratum corneum. The stratum corneum is a lipid-keratin hybrid and functions as the main biological barrier. This layer is always peeled and reconstructed in a process called desquamation. The dermis is the underlying layer that is the main structural support of the skin, and is largely extracellular and consists of collagen fibers.

  In addition to the horizontal stratified epidermis and dermis, the skin contains vertically aligned elements or cellular appendages. It contains a hair follicular sebaceous unit, which contains a hair follicle and a sebaceous gland. Each of the follicular sebaceous unit includes a sebaceous gland and a hair follicle. The sebaceous glands are closest to the surface and release sebum (oil) into the shaft of the hair follicle. The base of the hair follicle is called a valve. The base of the valve has a deep reproductive component called the dermal papilla. The hair follicles are typically arranged at an angle with respect to the skin surface. The hair follicles in a given area of the scalp are arranged to be parallel to each other. Although the follicular sebaceous unit is common throughout the entire outer skin, the density and activity of these units within the region of the scalp are key to the overall appearance of the hair.

  In addition to the follicular sebaceous unit, sweat glands extend vertically through the skin. They provide a water-based leachate that helps regulate body temperature. Apocrine sweat glands in the axilla and groin result in more irritating sweat, which causes body odor. For the rest of the body, the eccrine sweat glands drain hypoallergenic sweat to regulate temperature. Hair follicles go through different physiological cycles of hair growth.

  FIG. 26 shows the physiological cycle of hair growth. The presence of testosterone in genetic men produces a variable degree of alopecia in the scalp from the parietal to frontal. Basically, the hair follicle enters a resting state by entering the resting period without returning to the growth period. Male pattern baldness occurs when the hair fails to return from resting to growing.

  The PAD of the embodiment is configured for collective loading of plugs with hair accompanied by collective transplantation of hair-carrying plugs into a scalp without hair. This shortens conventional hair transplant surgery. In general, the devices, systems and / or methods of the embodiments are used to capture and align a large number of small hair carrying plugs in a single surgical step or process. Also, the recipient site is prepared by performing multiple pixel excision of the scalp without hair using the same instrument. A plurality of hair plug transplant tissues are transferred to a prepared recipient site in a lump and transplanted in a lump. As a result, hundreds of hair-carrying plugs can be transferred from the donor site to the recipient site through the use of a simplified approach. Thus, hair transplantation using the embodiments described herein provides a solution that is a single operation that is simpler, simpler and saves considerable time over cumbersome and multi-stage conventional processes.

  Hair transplantation using the pixel dermatome of the embodiment facilitates improvements over the conventional standard hair follicle unit extraction (FUT) hair transplant approach. In general, under the technique of the embodiment, the hair follicle to be taken up is taken from the occipital scalp of the donor. In doing so, the hair at the donor site is partially cut and the perforated plate of the embodiment is placed on the scalp and oriented to provide maximum yield. FIG. 27 shows donor hair follicle uptake under an embodiment. The skull pet of the skull pet array is configured to reach the subcutaneous fat layer to obtain a hair follicle. As detailed herein, once the hair plugs are incised, they are incorporated onto the adhesive membrane by traversing the base of the hair plug with a transverse blade. By applying an adhesive film before traversing the base, the original mutual arrangement of the hair plugs at the donor site is maintained. The aligned matrix of hair plugs on the adhesive membrane is then implanted in bulk into the recipient site of the scalp from the top of the recipient to the front.

  FIG. 28 shows the preparation of the recipient site under the embodiment. The recipient site is prepared by excising a hairless skin plug in a pattern that is systematically identical to the captured occipital scalp donor site. Under the embodiment, a recipient site is prepared for mass implantation of hair plugs using the same instrument used at the donor site. At that time, a scalp defect is generated at the recipient site. The scalp defect generated at the recipient site has the same geometry as the plug incorporated on the adhesive film.

  An adhesive film carrying the incorporated hair plug is applied over the same pattern of scalp defect at the recipient site. For each row, each hair-carrying plug is inserted into the recipient defect in its mirror image relationship. FIG. 29 shows the arrangement of incorporated hair plugs at a recipient site, under an embodiment. The alignment between plugs is maintained. Thus, hair that grows from an implanted hair plug lines up as naturally as it grows at the donor site. A more uniform alignment between the original scalp and the transplanted hair will also occur.

  Specifically, the donor site hair is partially cut to prepare for placement or placement of the perforated plate on the scalp. A perforated plate is placed at the occipital scalp donor site to provide maximum yield. FIG. 30 shows the placement of a perforated plate at the donor site of the occipital scalp, under an embodiment. Mass uptake of the hair plug is accomplished using a spring-loaded pixelated device with an impact punch handpiece with a skull pet disposable end. Embodiments are configured for the incorporation of individual hair plugs using off-the-shelf FUE extraction devices or biopsy punches. The pore size of the perforated plate supplied covers ready-made technology.

  A skull pet with a skull pet array disposable end is configured to reach the subcutaneous fat layer to obtain a hair follicle. FIG. 31 shows the penetration depth of the skull pet into the skin when the skull pet is configured to penetrate the subcutaneous fat layer and obtain a hair follicle under the embodiment. Once the hair plugs are incised, they are incorporated on the adhesive film by traversing the base of the hair plug with a transverse blade, but is not limited to this. FIG. 32 illustrates hair plug uptake using a perforated plate at the occipital donor site, under an embodiment. By applying the adhesive film of the embodiment, the original mutual arrangement of the hair plugs is maintained. An adhesive film is applied before traversing the base of the resected pixel, but is not limited to this. The aligned matrix of hair plugs on the adhesive membrane is then implanted in bulk into the scalp recipient site from the parietal to frontal.

  Additional single hair plugs may be incorporated through the perforated plate. This is used, for example, to create a visible hairline. FIG. 33 shows the generation of a visible hairline under the embodiment. Visible hairline is determined and made with manual FUT technology. Visible hairline and mass transplantation of vertices may be performed simultaneously or as separate stages. If the visible hairline and mass transplant are performed simultaneously, the recipient site is developed starting with a visible hairline.

  Implanted hair plug implantation involves preparing a recipient site by excising a hairless skin plug in a pattern that is structurally identical to the pattern of the captured occipital scalp donor site. FIG. 34 illustrates the preparation of a donor site for generating identical skin defects at a recipient site using a patterned perforated plate and a spring pixelated device, under an embodiment. The recipient site of the embodiment is prepared for mass implantation of hair plugs using the same perforated plate and spring pixelated device used at the donor site. A scalp defect is generated at the recipient site. These scalp defects have the same geometric shape as the plugs incorporated on the adhesive film.

  An adhesive film carrying the incorporated hair plug is applied over the same pattern of scalp defect at the recipient site. For each row, each hair follicle possession or hair possessing skin plug is inserted into a recipient defect that is in its mirror image. FIG. 35 illustrates implantation of an incorporated plug by inserting the incorporated plug into a corresponding skin defect created at the recipient site, under an embodiment. The alignment between plugs is maintained. Thus, hair that grows from an implanted hair plug lines up as naturally as it grows at the donor site. A more uniform alignment between the original scalp and the transplanted hair will also occur.

  The clinical endpoint varies from patient to patient, but a higher rate is expected than the hair plug "takes" as a result of improved angiogenesis. FIG. 36 illustrates a clinical endpoint using a pixel dermatome instrument and technique, under an embodiment. The combination of a better “take”, a shorter surgical period and a more natural looking result enables the pixel dermatome device and technique of the embodiment to overcome the shortcomings of conventional hair transplant approaches.

  Embodiments of pixelated skin grafts for skin defects and pixelated skin resections for skin relaxation are detailed herein. These embodiments remove skin pixel fields in relaxed skin areas where skin tightening is desired. Skin defects created by this approach (eg, in the range of about 1.5-3 mm in diameter) are small enough to provide primary healing without leaving visible scars. Occlusion of a plurality of skin defect wounds is directed to produce a desired contouring effect. Animal experiments with pixel removal techniques have performed well.

  The pixel method of the embodiment is performed under local anesthesia in an office setting, but is not limited thereto. The surgeon uses the instrument of the embodiment to quickly ablate an array of skin pixels (eg, circular, oval, square, etc.). The pain associated with that technique is relatively small. Intradermal skin defects created during surgery are closed by application of adhesive Flexan (3M) sheets, but are not limited thereto. The Flexan sheet acts as a large butterfly bandage and is pulled in a direction that maximizes aesthetic contouring of the treatment area. A compressible elastic garment may be applied over the bandage to aid in aesthetic contouring. During recovery, the patient wears a support garment over the treatment area for a period of time (eg, five days). After initial healing, many small linear scars in the treatment area are not visually noticeable.

  Additional skin tightening will occur over a period of months from the delayed wound healing response. As a result, the pixel approach is the least invasive alternative for skin tightening in areas where large scars of conventional cosmetic surgery should be avoided.

  The pixel approach elicits cellular and extracellular responses that are essential to the clinical outcome achieved. Physical contraction of the skin surface area occurs due to partial skin resection. This excision directly removes a portion of the skin in the relaxed area. In addition, subsequent skin tightening is achieved by a delayed wound healing response. Each pixelated ablation initiates a mandatory wound healing sequence. As already detailed herein, a healing response that is effective in an embodiment comprises three phases.

  The first phase of this sequence is the inflammatory phase, where degranulation of mast cells releases histamine into the “wound”. Histamine release causes dilation of the capillary bed and increases vascular permeability into the extracellular space. This initial wound healing response occurs within the first day and appears as erythema on the skin surface.

  Within a few days of the “wound”, the second phase of healing or fibrosis begins. During fibrosis, there is fibroblast metastasis and mitotic proliferation.

  Fibrosis has two key features. That is, the deposition of new collagen and the myofibroblastic contraction of the wound. Histologically, the deposition of new collagen is microscopically identified as cell compaction and thickening of the dermis. Although this is a static process, the skin tension increases considerably. Myoblastic contraction is a dynamic physical process that causes two-dimensional tightening of the skin surface. This process results from active cell contraction of myofibroblasts and the deposition of contractile proteins within the extracellular matrix. Overall, the effect of fibroproliferation is dermal contraction and the deposition of new collagen as a static supporting scaffold material with a reinforcing framework. The clinical effect manifests as a delayed tightening of the skin with a smooth feel over several months. The clinical endpoint is a skin envelope that looks more youthful in the treatment area.

  The third and final phase of the delayed wound healing response is maturity. During maturation, strengthening and remodeling of the treatment area occurs due to increased interlinkage of the (dermal) collagen fiber matrix. This final stage begins within 6 to 12 months after the “wound” and may last at least 1 to 2 years. Small pixelated excision of the skin preserves the normal dermal architecture during maturation, but this does not involve the production of noticeable scars. The scar often occurs with surgical removal of larger skin. Finally, the release of epidermal growth hormone results in the associated stimulation and rejuvenation of the epidermis.

  FIGS. 37 to 42 are images of the results of the pixel technique performed on live animals under the embodiment. The embodiments described herein were used in animal models in this demonstration experiment, which demonstrated that the pixel approach produces aesthetic skin tightening without leaving visible scars. The experiment used a live pig model anesthetized for surgery. FIG. 37 is an image of skin that has been engraved at the corners and midpoints of the region to be excised, under the embodiment. For postoperative evaluation, the field margin for resection was distinguished by tattoo, but is not limited to this. The procedure was performed using a perforated plate (eg, a 10 × 10 pixel array) to specify the area of partial ablation. Partial excision was performed using a biopsy punch (eg, 1.5 mm diameter). FIG. 38 is an image of a postoperative skin resection field according to an embodiment. After pixel ablation, the pixelated ablation defect was closed (horizontally) with the Flexan membrane.

  Eleven days after surgery, all resections within the area designated by the tattoo were healed primarily, and photographic and dimensional measurements were made. FIG. 39 is an image 11 days after surgery, showing the primary healing of the ablation with the measured margin, under the embodiment. At 29 days after surgery, photographic and dimensional measurements were subsequently made. FIG. 40 is an image after 29 days of surgery under an embodiment showing the ablation with primary margin, along with the measured margin that the ablation is primary healing and primary maturation continues. is there. FIG. 41 is an image after 29 days from surgery under the embodiment, showing the ablation primarily heals and the primary maturation of the ablation field continues with measured lateral dimensions It is.

  Photographic and dimensional measurements were repeated 90 days after surgery. The skin in the test area was completely smooth to the touch. FIG. 42 is an image after 90 days post-surgery, according to an embodiment, showing the ablation with primary healing along with the measured transverse dimension that the primary maturation of the ablation field continues. It is.

  Embodiments include an apparatus comprising a housing configured to include a skull pet device. The sculpture device includes a substrate and a sculpture array. The sculpture array includes a plurality of sculptures arranged in a configuration on a substrate. The substrate and the plurality of skull pets are configured to exit the housing and to enter the housing. The plurality of scalpets are configured to generate a plurality of incision skin pixels at the target site when exiting.

An embodiment is a skull pet device having a housing configured to include a skull pet device, a substrate and a skull pet array, wherein the skull pet array includes a plurality of skull pets arranged in a configuration on the substrate. A skull pet device comprising: a substrate and a plurality of skull pets configured to exit the housing and to enter the housing, wherein the plurality of skull pets are configured to generate a plurality of incision skin pixels at the target site; And a device comprising:
The housing is configured to be removably coupled with the receiver.
The receiver is a component of the control device.
The control device includes a proximal end and a distal end, the proximal end includes a drive mechanism, and the distal end includes a receiver.
The sculpture array is configured to exit in response to activation of the drive mechanism.
The proximal end of the control device is configured to be hand held.
The sculpture device is configured to cause the sculpture array to exit the sculpture device and back into the sculpture device in response to activation of the drive mechanism.
The sculpture device is configured such that the sculpture array exits the sculpture device in response to activation of the drive mechanism.
The sculpture device is configured such that the sculpture array enters the sculpture device back upon the release of the drive mechanism.
The control device is configured to be disposable.
The control device is configured to perform at least one of cleaning, disinfection, and sterilization.
The apparatus comprises an adhesive substrate configured to acquire a plurality of incision skin pixels.
The sculpture device is configured to include an adhesive substrate.
The housing is configured to include an adhesive substrate.
The adhesive substrate includes a flexible substrate.
The adhesive substrate includes a semi-porous film.
The apparatus comprises a vacuum component.
The vacuum component is coupled to the housing.
The vacuum component is coupled to the sculpture device.
The vacuum component is coupled to the skull pet device via a housing.
The vacuum component is configured to create a low pressure zone in at least one of the skull pet device and the control device.
The low pressure zone is configured to remove a plurality of incision skin pixels.
The housing is configured to be removably coupled with the control device, and the vacuum component is coupled with the control device.
The device comprises a radio frequency (RF) component.
The RF component is configured to provide thermal energy to at least one of the skull pet device and the skull pet array.
The RF component is configured to provide vibration energy to at least one of the skull pet device and the skull pet array.
The RF component is configured to provide rotational energy to at least one of the skull pet device and the skull pet array.
The RF component is configured to provide acoustic energy to at least one of the skull pet device and the skull pet array.
The RF component is coupled to the housing.
The RF component is coupled to the skull pet device.
The RF component is coupled to the skull pet device via a housing.
The RF component is coupled to the sculpture array.
The RF component is coupled to the sculpture array via a housing.
The RF component is coupled to at least one skullpet of the skullpet array.
The RF component is coupled to at least one skull pet of the skull pet array via a housing.
The housing is configured to be removably coupled with the control device, and the RF component is coupled with the control device.
The apparatus comprises a vacuum component coupled to at least one of the skull pet device and the housing, and a radio frequency (RF) component coupled to at least one of the skull pet device, the skull pet array and the housing.
The vacuum component is configured to create a low pressure zone in at least one of the skull pet device and the housing.
The RF component is configured to provide energy to at least one of the skull pet device, the skull pet array, and the housing.
The energy includes at least one of thermal energy, vibration energy, rotational energy, and acoustic energy.
The target site includes the recipient site, and the incision skin pixel creates a skin defect at the recipient site.
The target site includes a donor site, and multiple incision skin pixels are captured at the donor site.
The target site includes the recipient site, and the incision skin pixel creates a skin defect at the recipient site.
The apparatus includes an adhesive substrate configured to acquire a plurality of incision skin pixels at a donor site and to transfer the plurality of incision skin pixels to a recipient site.
The adhesive substrate is configured to maintain the relative position of the plurality of incision skin pixels while being transferred to and applied to the recipient site.
The adhesive substrate is configured to apply the incision skin pixel to the skin defect at the recipient site.
The adhesive substrate is configured to align the incision skin pixel with the skin defect at the recipient site.
The adhesive substrate is configured to insert each incision skin pixel into a corresponding skin defect at the recipient site.
The apparatus comprises at least one bandage configured to be applied to the target site.
At least one bandage is configured to apply a force to close the target site.
At least one bandage is configured to apply a directional force to control the direction of closure at the target site.
The at least one bandage includes a first bandage configured to be applied to the donor site.
The at least one bandage includes a second bandage configured to be applied to the recipient site.
The sculpture device is configured to transfer the load to the underlying skin surface containing the target site, and the skin pixel is incised by application of the load.
The sculpture array is configured to transfer a load to the underlying skin surface containing the target site, and the skin pixels are dissected by the application of the load.
The skull pet device is configured to be disposable.
The skull pet device is configured to perform at least one of cleaning, disinfection, and sterilization.
The apparatus comprises a template configured to be placed at a target site.
The skull pet device is configured to align with the template.
The skull pet array is configured to align with the template.
The template is on the target skin surface.
The template includes an indicator on the skin surface of the target site.
The template is configured for placement at the target site and includes a guide plate that includes holes arranged in a pattern.
The skull pet array is removably coupled to the skull pet device.
The skull pet array is disposable.
The shape of each skull pet of the skull pet array is an ellipse.
The shape of each skull pet of the skull pet array is circular.
The shape of each skull pet in the skull pet array is semicircular.
The shape of each skull pet of the skull pet array is one of square, rectangular and flat.
Each skull pet of at least one skull pet includes a slope.
Each skull pet of the plurality of skull pets includes at least one pointed surface.
Each skull pet of the plurality of skull pets includes at least one needle.
The at least one needle includes at least one needle including a plurality of tips.
The sculpture array generates an incision skin pixel using at least one of a piercing force, an impact force, and a rotational force.
The sculpture array uses radio frequency (RF) energy to create incision skin pixels.
The sculpture array uses vibrational energy to generate incision skin pixels.
At least one skull pet of the skull pet array includes a through orifice.
At least one radial dimension of each scalpet of the scalpet array is in the range of approximately 0.5 millimeters to 4.0 millimeters.
The apparatus includes a guide plate configured to be placed as a template for a target site, the guide plate including holes arranged in a pattern.
The sculpture array is configured to align with the holes in the guide plate. The sculpture array is applied to the donor site through a hole in the guide plate and a plurality of skin pixels are incised.
The sculpture array is applied to the recipient site through the holes in the guide plate and multiple skin defects are created.
Target sites include donor sites and recipient sites.
A plurality of incision skin pixels and a plurality of skin defects are generated according to the pattern.
The apparatus includes an adhesive substrate configured to acquire a plurality of incision skin pixels at a donor site and to transfer the plurality of incision skin pixels to a recipient site.
The adhesive substrate is configured to maintain the relative position of the plurality of incision skin pixels while being transferred to and applied to the recipient site.
The sculpture array is applied directly to the donor site through the hole and the skin pixel is incised.
The sculpture array is applied directly to the recipient site through the hole and a skin defect is created.
The guide plate is at least one of adhesive, hard, semi-rigid, flexible, non-flexible, and non-variable.
The guide plate includes at least one of a metal material, a plastic material, a polymer material, and a film material.
The guide plate is configured to transmit the load to the skin surface of at least one of the donor site and the recipient site.
The guide plate is placed directly on the skin surface of the target site.
The guide plate is configured to extrude a plurality of incision skin pixels.
The plurality of skin pixels are pushed through the hole in response to the applied load.
The plurality of skin pixels are pushed through the cut skin surface according to the applied load.
The apparatus includes a cutting member.
The incision skin pixel is traversed by the cutting member.
The apparatus includes an adhesive substrate configured to acquire an incision skin pixel.
The cutting member is coupled to the frame.
The frame is coupled to a guide plate, and the guide plate is configured as a guide for the skull pet device.
The adhesive substrate is bonded to at least one of the frame and the guide plate. The incision skin pixel includes a hair follicle.
The skin defect is configured to cause angiogenesis in the incised skin pixel inserted at the recipient site.
The skin defect is configured to cause a wound healing response to the incised skin pixel inserted at the recipient site.
An embodiment is a skull pet device having a housing including a skull pet device and a skull pet array including a plurality of skull pets arranged in a pattern, the plurality of skull pets having a plurality of incision skin pixels at a target site And a scalpel device that can exit the housing to produce the device.
Embodiments include an apparatus comprising a housing that includes a skull pet device. The sculpture device includes a sculpture array that includes a plurality of sculptures arranged in a pattern. Multiple scalpets can exit the housing to create multiple incision skin pixels at the target site.
Embodiments include a system comprising a control device having a proximal end and a distal end. The proximal end includes a drive mechanism and the distal end includes a receiver. The system includes a sculpture device configured to be removably coupled with a receiver of the control device. The sculpture device includes a substrate and a sculpture array, and the sculpture array includes a plurality of sculptures arranged in a configuration on the substrate. The substrate and the plurality of scalpets are configured to exit in response to activation of the drive mechanism. The plurality of scalpets are configured to generate a plurality of incision skin pixels at the target site when exiting.
An embodiment is a control device that includes a proximal end and a distal end, wherein the proximal end includes a drive mechanism and the distal end includes a receiver that is removable from the control device and the receiver of the control device A sculpture device configured to be coupled, the sculpture device including a substrate and a sculpture array, wherein the sculpture array includes a plurality of sculptures arranged in a configuration on the substrate, the substrate and the plurality A system comprising: a skull pet device configured to exit upon activation of the drive mechanism, wherein the plurality of skull pets are configured to generate a plurality of incision skin pixels at the target site upon exit; including.
The proximal end of the control device is configured to be hand held.
The target site includes the recipient site, and the incision skin pixel creates a skin defect at the recipient site.
The target site includes a donor site, and multiple incision skin pixels are captured at the donor site.
The target site includes the recipient site, and the incision skin pixel creates a skin defect at the recipient site.
The system includes an adhesive substrate configured to acquire a plurality of incision skin pixels at a donor site and to transfer the plurality of incision skin pixels to a recipient site.
The adhesive substrate is configured to maintain the relative position of the plurality of incision skin pixels while being transferred to and applied to the recipient site.
The adhesive substrate is configured to apply the incision skin pixel to the skin defect at the recipient site.
The adhesive substrate is configured to align the incision skin pixel with the skin defect at the recipient site.
The adhesive substrate is configured to insert each incision skin pixel into a corresponding skin defect at the recipient site.
The system comprises at least one bandage configured to be applied to the target site.
At least one bandage is configured to apply a force to close the target site.
At least one bandage is configured to apply a directional force to control the direction of closure at the target site.
The at least one bandage includes a first bandage configured to be applied to the donor site.
The at least one bandage includes a second bandage configured to be applied to the recipient site.
The system comprises an adhesive substrate configured to acquire a plurality of incision skin pixels.
The sculpture device is configured to include an adhesive substrate.
The adhesive substrate includes a flexible substrate.
The adhesive substrate includes a semi-porous film.
The sculpture device is configured to cause the sculpture array to exit the sculpture device and back into the sculpture device in response to activation of the drive mechanism.
The sculpture device is configured such that the sculpture array exits the sculpture device in response to activation of the drive mechanism.
The sculpture device is configured such that the sculpture array enters the sculpture device back upon the release of the drive mechanism.
The sculpture device is configured to transfer the load to the underlying skin surface containing the target site, and the skin pixel is incised by application of the load.
The sculpture array is configured to transfer a load to the underlying skin surface containing the target site, and the skin pixels are dissected by the application of the load.
The skull pet device is configured to be disposable.
The skull pet device is configured to perform at least one of cleaning, disinfection, and sterilization.
The control device is configured to be disposable.
The control device is configured to perform at least one of cleaning, disinfection, and sterilization.
The system includes a template configured to be deployed at a target site.
The skull pet device is configured to align with the template.
The skull pet array is configured to align with the template.
The template is on the target skin surface.
The template includes an indicator on the skin surface of the target site.
The template is configured for placement at the target site and includes a guide plate that includes holes arranged in a pattern.
The skull pet array is removably coupled to the skull pet device.
The skull pet array is disposable.
The shape of each skull pet of the skull pet array is an ellipse.
The shape of each skull pet of the skull pet array is circular.
The shape of each skull pet in the skull pet array is semicircular.
The shape of each skull pet of the skull pet array is one of square, rectangular and flat.
Each skull pet of at least one skull pet includes a slope.
Each skull pet of the plurality of skull pets includes at least one pointed surface.
Each skull pet of the plurality of skull pets includes at least one needle.
The at least one needle includes at least one needle including a plurality of tips.
The sculpture array generates an incision skin pixel using at least one of a piercing force, an impact force, and a rotational force.
The sculpture array uses radio frequency (RF) energy to create incision skin pixels.
The sculpture array uses vibrational energy to generate incision skin pixels. At least one skull pet of the skull pet array includes a through orifice.
At least one radial dimension of each scalpet of the scalpet array is in the range of approximately 0.5 millimeters to 4.0 millimeters.
The system comprises a vacuum component.
The vacuum component is coupled to the control device.
The vacuum component is coupled to the sculpture device.
The vacuum component is coupled to the sculpture device via a control device.
The vacuum component is configured to create a low pressure zone in at least one of the skull pet device and the control device.
The low pressure zone is configured to remove a plurality of incision skin pixels.
The system comprises a radio frequency (RF) component.
The RF component is configured to provide thermal energy to at least one of the skull pet device, the skull pet array, and the control device.
The RF component is configured to provide vibrational energy to at least one of the skull pet device, the skull pet array, and the control device.
The RF component is configured to provide rotational energy to at least one of the skull pet device, the skull pet array, and the control device.
The RF component is configured to provide acoustic energy to at least one of the skull pet device, the skull pet array, and the control device.
The RF component is coupled to the control device.
The RF component is coupled to the skull pet device.
The RF component is coupled to the sculpture device via a control device.
The RF component is coupled to the sculpture array.
The RF component is coupled to the sculpture array via a control device.
The RF component is coupled to at least one skullpet of the skullpet array.
The RF component is coupled to at least one skullpet of the skullpet array via a control device.
The system includes a vacuum component coupled with at least one of the sculpture device and the control device, and a radio frequency (RF) component coupled with at least one of the sculpture device, the sculpture array and the control device. Prepare.
The vacuum component is configured to create a low pressure zone in at least one of the skull pet device and the control device.
The RF component is configured to provide energy to at least one of the skull pet device, the skull pet array, and the control device.
The energy includes at least one of thermal energy, vibration energy, rotational energy, and acoustic energy.
The system includes a guide plate configured to be placed as a template for a target site, the guide plate including holes arranged in a pattern.
The sculpture array is configured to align with the holes in the guide plate.
The sculpture array is applied to the donor site through a hole in the guide plate and a plurality of skin pixels are incised.
The sculpture array is applied to the recipient site through the holes in the guide plate and multiple skin defects are created.
Target sites include donor sites and recipient sites.
A plurality of incision skin pixels and a plurality of skin defects are generated according to the pattern.
The system includes an adhesive substrate configured to acquire a plurality of incision skin pixels at a donor site and to transfer the plurality of incision skin pixels to a recipient site.
The adhesive substrate is configured to maintain the relative position of the plurality of incision skin pixels while being transferred to and applied to the recipient site.
The sculpture array is applied directly to the donor site through the hole and the skin pixel is incised.
The sculpture array is applied directly to the recipient site through the hole and a skin defect is created.
The guide plate is at least one of adhesive, hard, semi-rigid, flexible, non-flexible, and non-variable.
The guide plate includes at least one of a metal material, a plastic material, a polymer material, and a film material.
The guide plate is configured to transmit the load to the skin surface of at least one of the donor site and the recipient site.
The guide plate is placed directly on the skin surface of the target site.
The guide plate is configured to extrude a plurality of incision skin pixels.
The plurality of skin pixels are pushed through the hole in response to the applied load.
The plurality of skin pixels are pushed through the cut skin surface according to the applied load.
The system includes a cutting member.
The incision skin pixel is traversed by the cutting member.
The adhesive substrate is configured to acquire an incision skin pixel.
The cutting member is coupled to the frame.
The frame is coupled to a guide plate, and the guide plate is configured as a guide for the skull pet device.
The adhesive substrate is bonded to at least one of the frame and the guide plate. The incision skin pixel includes a hair follicle.
The skin defect is configured to cause angiogenesis in the incised skin pixel inserted at the recipient site.
The skin defect is configured to cause a wound healing response to the incised skin pixel inserted at the recipient site.
Embodiments include a system comprising a control device. The system includes a skull pet device removably coupled with a control device. The skull pet device includes a skull pet array having a plurality of skull pets arranged in a pattern. The plurality of sculptures are configured to enter and exit in response to activation by the control device and to generate a plurality of incision skin pixels at the target site.
An embodiment is a control device and a scalpel device removably coupled to the control device, the scalpel device including a scalpet array having a plurality of scalpets arranged in a pattern, the plurality of scalpets Comprises a system comprising: a scalpel device that enters and exits upon activation by the control device and is configured to generate a plurality of incision skin pixels at the target site.
Embodiments include a system comprising a control device having a drive mechanism. The system includes a scalpel device configured to be removably coupled with the control device. The sculpture device includes a substrate and a sculpture array, and the sculpture array includes a plurality of sculptures arranged in a pattern on the substrate. The substrate and the plurality of scalpets are configured to perform at least one of exiting and entering in response to activation of the drive mechanism. The plurality of scalpets are configured to generate a plurality of incision skin pixels at the target site when exiting.
An embodiment is a control device having a drive mechanism and a skull pet device configured to be removably coupled to the control device, the skull pet device including a substrate and a skull pet array, A plurality of scalpets arranged in a pattern on the substrate, the substrate and the plurality of scalpets configured to perform at least one of exiting and entering in response to activation of the drive mechanism; Includes a system comprising a scalpel device configured to generate a plurality of incision skin pixels at a target site upon exit.
Embodiments include a system comprising a housing configured to include a skull pet device. The sculpture device includes a substrate and a sculpture array. The sculpture array includes a plurality of sculptures arranged in a configuration on a substrate. The substrate and the plurality of skull pets are configured to exit the housing and to enter the housing. The plurality of scalpets are configured to generate a plurality of incision skin pixels at the target site when exiting. The system includes a vacuum component configured to create a low pressure zone next to the skull pet device.
An embodiment is a skull pet device having a housing configured to include a skull pet device, a substrate and a skull pet array, wherein the skull pet array includes a plurality of skull pets arranged in a configuration on the substrate. A skull pet device comprising: a substrate and a plurality of skull pets configured to exit the housing and to enter the housing, wherein the plurality of skull pets are configured to generate a plurality of incision skin pixels at the target site; And a vacuum component configured to create a low pressure zone next to the sculpture device.
The vacuum component is coupled to the housing.
The vacuum component is coupled to the sculpture device.
The vacuum component is coupled to the skull pet device via a housing.
The vacuum component is configured to create a low pressure zone within the housing.
The low pressure zone is configured to remove a plurality of incision skin pixels.
The housing is configured to be removably coupled with the receiver.
The receiver is a component of the control device.
The control device includes a proximal end and a distal end, the proximal end includes a drive mechanism, and the distal end includes a receiver.
The sculpture array is configured to exit in response to activation of the drive mechanism.
The proximal end of the control device is configured to be hand held.
The sculpture device is configured to cause the sculpture array to exit the sculpture device and back into the sculpture device in response to activation of the drive mechanism.
The sculpture device is configured such that the sculpture array exits the sculpture device in response to activation of the drive mechanism.
The sculpture device is configured such that the sculpture array enters the sculpture device back upon the release of the drive mechanism.
The control device is configured to be disposable.
The control device is configured to perform at least one of cleaning, disinfection, and sterilization.
The system comprises an adhesive substrate configured to acquire a plurality of incision skin pixels.
The sculpture device is configured to include an adhesive substrate.
The housing is configured to include an adhesive substrate.
The adhesive substrate includes a flexible substrate.
The adhesive substrate includes a semi-porous film.
The system comprises a radio frequency (RF) component.
The RF component is configured to provide thermal energy to at least one of the skull pet device and the skull pet array.
The RF component is configured to provide vibration energy to at least one of the skull pet device and the skull pet array.
The RF component is configured to provide rotational energy to at least one of the skull pet device and the skull pet array.
The RF component is configured to provide acoustic energy to at least one of the skull pet device and the skull pet array.
The RF component is coupled to the housing.
The RF component is coupled to the skull pet device.
The RF component is coupled to the skull pet device via a housing.
The RF component is coupled to the sculpture array.
The RF component is coupled to the sculpture array via a housing.
The RF component is coupled to at least one skullpet of the skullpet array.
The RF component is coupled to at least one skull pet of the skull pet array via a housing.
The housing is configured to be removably coupled with the control device, and the RF component is coupled with the control device.
The target site includes the recipient site, and the incision skin pixel creates a skin defect at the recipient site.
The target site includes a donor site, and multiple incision skin pixels are captured at the donor site.
The target site includes the recipient site, and the incision skin pixel creates a skin defect at the recipient site.
The system includes an adhesive substrate configured to acquire a plurality of incision skin pixels at a donor site and to transfer the plurality of incision skin pixels to a recipient site.
The adhesive substrate is configured to maintain the relative position of the plurality of incision skin pixels while being transferred to and applied to the recipient site.
The adhesive substrate is configured to apply the incision skin pixel to the skin defect at the recipient site.
The adhesive substrate is configured to align the incision skin pixel with the skin defect at the recipient site.
The adhesive substrate is configured to insert each incision skin pixel into a corresponding skin defect at the recipient site.
The system comprises at least one bandage configured to be applied to the target site.
At least one bandage is configured to apply a force to close the target site. At least one bandage is configured to apply a directional force to control the direction of closure at the target site.
The at least one bandage includes a first bandage configured to be applied to the donor site.
The at least one bandage includes a second bandage configured to be applied to the recipient site.
The sculpture device is configured to transfer the load to the underlying skin surface containing the target site, and the skin pixel is incised by application of the load.
The sculpture array is configured to transfer a load to the underlying skin surface containing the target site, and the skin pixels are dissected by the application of the load.
The skull pet device is configured to be disposable.
The skull pet device is configured to perform at least one of cleaning, disinfection, and sterilization.
The system includes a template configured to be deployed at a target site. The skull pet device is configured to align with the template.
The skull pet array is configured to align with the template.
The template is on the target skin surface.
The template includes an indicator on the skin surface of the target site.
The template is configured for placement at the target site and includes a guide plate that includes holes arranged in a pattern.
The skull pet array is removably coupled to the skull pet device.
The skull pet array is disposable.
The shape of each skull pet of the skull pet array is an ellipse.
The shape of each skull pet of the skull pet array is circular.
The shape of each skull pet in the skull pet array is semicircular.
The shape of each skull pet of the skull pet array is one of square, rectangular and flat. Each skull pet of at least one skull pet includes a slope.
Each skull pet of the plurality of skull pets includes at least one pointed surface. Each skull pet of the plurality of skull pets includes at least one needle.
The at least one needle includes at least one needle including a plurality of tips. The sculpture array generates an incision skin pixel using at least one of a piercing force, an impact force, and a rotational force.
The sculpture array uses radio frequency (RF) energy to create incision skin pixels.
The sculpture array uses vibrational energy to generate incision skin pixels.
At least one skull pet of the skull pet array includes a through orifice.
At least one radial dimension of each scalpet of the scalpet array is in the range of approximately 0.5 millimeters to 4.0 millimeters.
The system includes a guide plate configured to be placed as a template for a target site, the guide plate including holes arranged in a pattern.
The sculpture array is configured to align with the holes in the guide plate.
The sculpture array is applied to the donor site through a hole in the guide plate and a plurality of skin pixels are incised.
The sculpture array is applied to the recipient site through the holes in the guide plate and multiple skin defects are created.
Target sites include donor sites and recipient sites.
A plurality of incision skin pixels and a plurality of skin defects are generated according to the pattern.
The system includes an adhesive substrate configured to acquire a plurality of incision skin pixels at a donor site and to transfer the plurality of incision skin pixels to a recipient site.
The adhesive substrate is configured to maintain the relative position of the plurality of incision skin pixels while being transferred to and applied to the recipient site.
The sculpture array is applied directly to the donor site through the hole and the skin pixel is incised.
The sculpture array is applied directly to the recipient site through the hole and a skin defect is created.
The guide plate is at least one of adhesive, hard, semi-rigid, flexible, non-flexible, and non-variable.
The guide plate includes at least one of a metal material, a plastic material, a polymer material, and a film material.
The guide plate is configured to transmit the load to the skin surface of at least one of the donor site and the recipient site.
The guide plate is placed directly on the skin surface of the target site.
The guide plate is configured to extrude a plurality of incision skin pixels.
The plurality of skin pixels are pushed through the hole in response to the applied load.
The plurality of skin pixels are pushed through the cut skin surface according to the applied load.
The system includes a cutting member.
The incision skin pixel is traversed by the cutting member.
The system includes an adhesive substrate configured to acquire an incision skin pixel.
The cutting member is coupled to the frame.
The frame is coupled to a guide plate, and the guide plate is configured as a guide for the skull pet device.
The adhesive substrate is bonded to at least one of the frame and the guide plate. The incision skin pixel includes a hair follicle.
The skin defect is configured to cause angiogenesis in the incised skin pixel inserted at the recipient site.
The skin defect is configured to cause a wound healing response to the incised skin pixel inserted at the recipient site.
Embodiments include a system comprising a housing that includes a skull pet device. The sculpture device includes a sculpture array that includes a plurality of sculptures arranged in a pattern. Multiple scalpets can exit the housing to create multiple incision skin pixels at the target site. The system includes a vacuum component configured to create a low pressure zone next to the skull pet device.
An embodiment is a skull pet device having a housing including a skull pet device and a skull pet array including a plurality of skull pets arranged in a pattern, the plurality of skull pets having a plurality of incision skin pixels at a target site And a vacuum component configured to create a low pressure zone next to the scalpel device.
Embodiments include a method that includes placing a housing with a skull pet device at a target site. The sculpture device includes a substrate and a sculpture array. The sculpture array includes a plurality of sculptures arranged in a configuration on a substrate. The method includes ejecting a sculpture array from a housing to tissue at a target site to generate a plurality of incision skin pixels at the target site. The method includes returning the skull pet array from the target site into the housing.
An embodiment is to place a housing containing a sculpture device at a target site, the sculpture device comprising a substrate and a sculpture array, wherein the sculpture array is arranged in a plurality of configurations on the substrate. Including a sculpture, removing a sculpture array from the housing to the tissue at the target site to generate a plurality of incision skin pixels at the target site, returning the sculpture array from the target site into the housing; Including methods.
The method includes coupling the housing and a receiver that is a component of the control device.
The control device includes a proximal end and a distal end, the proximal end includes a drive mechanism, and the distal end includes a receiver.
Ejecting includes ejecting the sculpture array in response to activation of the drive mechanism.
Scalpet array according to the activation of the drive mechanism.
Returning includes returning the sculpture array in response to the release of the drive mechanism.
The proximal end of the control device is configured to be hand held.
The method includes moving the skull pet device away from the receiver and positioning the skull pet device.
The method includes at least one of cleaning, disinfection, and sterilization of the control device.
The method includes obtaining a plurality of incision skin pixels using an adhesive substrate.
The sculpture device includes an adhesive substrate.
The housing includes an adhesive substrate.
The adhesive substrate includes a flexible substrate.
The adhesive substrate includes a semi-porous film.
The method includes incorporating a plurality of incision skin pixels.
Incorporating includes removing a plurality of incision skin pixels.
Incorporating includes creating a low pressure zone in at least one of the skull pet device and the housing.
The creation of the low pressure zone involves using a vacuum component.
The vacuum component is coupled to the housing.
The vacuum component is coupled to the sculpture device.
The vacuum component is coupled to the skull pet device via a housing.
The housing is configured to be removably coupled with the control device, and the vacuum component is coupled with the control device.
Generating the plurality of incision skin pixels includes providing energy to at least one of the skull pet device, the skull pet array, and the housing.
Providing energy includes using radio frequency (RF) components.
The energy includes at least one of thermal energy, vibration energy, rotational energy, and acoustic energy.
Providing energy includes providing thermal energy to at least one of the skull pet device and the skull pet array.
Providing energy includes providing vibrational energy to at least one of the skull pet device and the skull pet array.
Providing energy includes providing rotational energy to at least one of the skull pet device and the skull pet array.
Providing energy includes providing acoustic energy to at least one of the skull pet device and the skull pet array.
The RF component is coupled to the housing.
The RF component is coupled to the skull pet device.
The RF component is coupled to the skull pet device via a housing.
The RF component is coupled to the sculpture array.
The RF component is coupled to the sculpture array via a housing.
The RF component is coupled to at least one skullpet of the skullpet array.
The RF component is coupled to at least one skull pet of the skull pet array via a housing.
The housing is configured to be removably coupled with the control device, and the RF component is coupled with the control device.
The method includes incorporating a plurality of incision skin pixels using a vacuum component, and the generation of the plurality of incision skin pixels includes using radio frequency (RF) energy.
The vacuum component is configured to create a low pressure zone in at least one of the skull pet device and the housing.
The RF component is configured to provide energy to at least one of the skull pet device, the skull pet array, and the housing.
The energy includes at least one of thermal energy, vibration energy, rotational energy, and acoustic energy.
The target site includes the recipient site, and the incision skin pixel creates a skin defect at the recipient site.
The target site includes a donor site, and multiple incision skin pixels are captured at the donor site.
The target site includes the recipient site, and the incision skin pixel creates a skin defect at the recipient site.
The method includes obtaining a plurality of incision skin pixels using an adhesive substrate and transferring the plurality of incision skin pixels to a recipient site.
The method includes the adhesive substrate maintaining a relative position of the plurality of incision skin pixels during transfer to the recipient site.
The method includes applying a plurality of incision skin pixels from an adhesive substrate to a skin defect at a recipient site.
The method includes aligning a plurality of incision skin pixels with a skin defect at a recipient site using an adhesive substrate.
The method includes inserting each incision skin pixel from a sticky substrate into a corresponding skin defect at a recipient site.
The method includes applying at least one bandage to the target site.
Applying at least one bandage includes applying a force to close the target site.
Applying at least one bandage includes applying a directional force to control the direction of closure at the target site.
Applying at least one bandage includes applying a first bandage at the donor site.
Applying at least one bandage includes applying a second bandage at the recipient site.
Generating a plurality of incision skin pixels includes transferring a load through a sculpture device to a lower skin surface including a target site, the skin pixel being incised by application of the load.
Generating a plurality of incision skin pixels includes transferring a load through a sculpture array to a lower skin surface including a target site, where the skin pixels are incised by application of the load.
The skull pet device is configured to be disposable.
The skull pet device is configured to perform at least one of cleaning, disinfection, and sterilization.
The method includes placing a template at a target site.
The method includes aligning a skull pet device with a template.
The method includes aligning a skull pet array with a template.
Placing includes placing a template on the skin surface of the target site.
The template includes an indicator on the skin surface of the target site.
The template is configured for placement at the target site and includes a guide plate that includes holes arranged in a pattern.
The method includes removably coupling a sculpture array to a sculpture device.
The skull pet array is disposable.
The shape of each skull pet of the skull pet array is an ellipse.
The shape of each skull pet of the skull pet array is circular.
The shape of each skull pet in the skull pet array is semicircular.
The shape of each skull pet of the skull pet array is one of square, rectangular and flat.
Each skull pet of the plurality of skull pets includes a slope.
Each skull pet of the plurality of skull pets includes at least one pointed surface.
Each skull pet of the plurality of skull pets includes at least one needle.
The at least one needle includes at least one needle including a plurality of tips.
Generating the plurality of incision pixels includes generating using at least one of a piercing force, an impact force, and a rotational force.
Generating the plurality of incision pixels includes generating using radio frequency (RF) energy.
Generating the plurality of incision pixels includes generating using vibrational energy.
At least one skull pet of the skull pet array includes a through orifice.
At least one radial dimension of each scalpet of the scalpet array is in the range of approximately 0.5 millimeters to 4.0 millimeters.
The method includes disposing a guide plate as a template for a target site, the guide plate including holes arranged in a pattern.
The method includes aligning the skull pet array with the holes in the guide plate.
The method includes applying a sculpture array to a donor site through a hole in a guide plate, wherein a plurality of skin pixels are incised.
The method includes applying a sculpture array to a recipient site through a hole in a guide plate, wherein a plurality of skin defects are generated.
Target sites include donor sites and recipient sites.
The method includes generating a plurality of incision skin pixels and a plurality of skin defects according to a pattern.
The method includes acquiring a plurality of incision skin pixels with an adhesive substrate at a donor site and transferring the plurality of incision skin pixels to a recipient site.
The method includes maintaining a relative position of the plurality of incision skin pixels with an adhesive substrate while being transferred to and applied to a recipient site.
The method includes applying a sculpture array directly through a hole to a donor site, and a skin pixel is incised.
The method includes applying a sculpture array directly to a recipient site through a hole and a skin defect is created.
The guide plate is at least one of adhesive, hard, semi-rigid, flexible, non-flexible, and non-variable.
The guide plate includes at least one of a metal material, a plastic material, a polymer material, and a film material.
The guide plate is configured to transmit the load to the skin surface of at least one of the donor site and the recipient site.
The method includes placing a guide plate directly on the skin surface of the target site.
The method includes extruding a plurality of incision skin pixels using a guide plate.
The method includes extruding a plurality of skin pixels through a hole in response to an applied load.
The method includes extruding a plurality of skin pixels through the incised skin surface in response to an applied load.
Generating a plurality of incision pixels includes incising with a cutting member.
The method includes traversing the incision skin pixel with a cutting member.
The method includes obtaining an incision skin pixel with an adhesive substrate.
The cutting member is coupled to the frame.
The frame is coupled to a guide plate, and the guide plate is configured as a guide for the skull pet device.
The adhesive substrate is bonded to at least one of the frame and the guide plate. The incision skin pixel includes a hair follicle.
The method includes using a skin defect to cause angiogenesis in an incised skin pixel inserted at a recipient site.
The method includes using a skin defect to cause a wound healing response in an incised skin pixel inserted at a recipient site.
An embodiment is to form a bond between a control device and a sculpture device, the control device including an actuator, wherein the sculpture device includes a sculpture array including a plurality of sculptures arranged in a pattern. Including the creation of multiple incision skin pixels and multiple skin defects by aligning the skull pet device at the target site and placing the skull pet array in the target site tissue, wherein the skull pet array is an actuator In response to activation of the method.
An embodiment is to form a bond between a control device and a sculpture device, the control device including an actuator, wherein the sculpture device includes a sculpture array including a plurality of sculptures arranged in a pattern. Including the creation of multiple incision skin pixels and multiple skin defects by aligning the skull pet device at the target site and placing the skull pet array in the target site tissue, wherein the skull pet array is an actuator In response to activation of the method.
An embodiment is to place a housing at a target site, the housing including a sculpture array including a plurality of sculptures arranged in a pattern, and delivering the sculpture array to tissue at the target site; If the target site is a donor site, generate multiple incision skin pixels at the target site; if the target site is a recipient site, generate multiple skin defects at the target site; Incorporating a skin pixel.
An embodiment is to place a housing at a target site, the housing including a sculpture array including a plurality of sculptures arranged in a pattern, and delivering the sculpture array to tissue at the target site; If the target site is a donor site, generate multiple incision skin pixels at the target site; if the target site is a recipient site, generate multiple skin defects at the target site; Incorporating a skin pixel.
An embodiment is to place a housing at the donor site, the housing including a sculpture array including a plurality of sculptures arranged in a pattern, and ejecting the sculpture array to tissue at the donor site, Generating a plurality of incision skin pixels; acquiring a plurality of incision skin pixels at a donor site; and transferring the incision skin pixels to a recipient; placing a housing at the recipient site; Applying a sculpture array to the tissue at the site to generate a plurality of skin defects and applying a plurality of incision skin pixels to the skin defect at the recipient site.
An embodiment is to place a housing at the donor site, the housing including a sculpture array including a plurality of sculptures arranged in a pattern, and ejecting the sculpture array to tissue at the donor site, Generating a plurality of incision skin pixels; acquiring a plurality of incision skin pixels at a donor site; and transferring the incision skin pixels to a recipient; placing a housing at the recipient site; Applying a sculpture array to the tissue at the site to generate a plurality of skin defects and applying a plurality of incision skin pixels to the skin defect at the recipient site.
An embodiment is to configure a housing to include a sculpture device, and to configure a sculpture device to include a substrate and a sculpture array, wherein the sculpture array is arranged in a configuration on the substrate. Configured to include a plurality of sculptures, the substrate and the plurality of sculptures configured to exit from and into the housing, and the plurality of sculptures generate multiple incision skin pixels at the target site upon exit Configured to include a method.
An embodiment is to configure a housing to include a sculpture device, and to configure a sculpture device to include a substrate and a sculpture array, wherein the sculpture array is arranged in a configuration on the substrate. Configured to include a plurality of sculptures, the substrate and the plurality of sculptures configured to exit from and into the housing, and the plurality of sculptures generate multiple incision skin pixels at the target site upon exit Configured to include a method.
The method includes configuring the housing to be removably coupled with the receiver.
The receiver is a component of the control device.
The method includes configuring the control device to include a proximal end and a distal end, the proximal end including a drive mechanism and the distal end including a receiver.
The method includes configuring the sculpture array to be ejected in response to activation of the drive mechanism.
The method includes configuring the control device to have a proximal end by hand.
The method includes configuring the sculpture device such that the sculpture array exits the sculpture device and enters the sculpture device in response to activation of the drive mechanism.
The method includes configuring the sculpture device such that the sculpture array exits the sculpture device in response to activation of the drive mechanism.
The method includes configuring the sculpture device such that the sculpture array enters the sculpture device back upon the release of the drive mechanism.
The method includes configuring the control device to be disposable.
The method includes configuring the control device to perform at least one of cleaning, disinfection, and sterilization.
The method includes configuring the adhesive substrate to acquire a plurality of incision skin pixels.
The method includes configuring the scalpel device to include an adhesive substrate.
The method includes configuring the housing to include an adhesive substrate.
The adhesive substrate includes a flexible substrate.
The adhesive substrate includes a semi-porous film.
The method includes configuring at least one of a housing, a skull pet device, and a skull pet array for use with a vacuum component.
The method includes configuring the housing for coupling with a vacuum component.
The method includes configuring the scalpet device for coupling with a vacuum component for coupling with the scalp device.
The method includes configuring a scalpel device for coupling with a vacuum component through a housing.
The method includes configuring at least one of the skull pet device and the control device to include a low pressure zone.
The method includes configuring the low pressure zone to retrieve a plurality of incision skin pixels.
The method includes configuring the housing to be removably coupled with the control device, and the vacuum component is coupled with the control device.
The method includes configuring at least one of a housing, a skull pet device, and a skull pet array for use with a radio frequency (RF) component.
The method includes configuring the RF component to provide thermal energy to at least one of the skull pet device and the skull pet array.
The method includes configuring the RF component to provide vibrational energy to at least one of the skull pet device and the skull pet array.
The method includes configuring the RF component to provide rotational energy to at least one of the skull pet device and the skull pet array.
The method includes configuring the RF component to provide acoustic energy to at least one of the skull pet device and the skull pet array.
The method includes coupling an RF component and a housing. The method includes coupling an RF component and a sculpture device.
The method includes coupling the RF component and the scalpel device via a housing.
The method includes combining an RF component and a sculpture array.
The method includes coupling an RF component and a sculpture array via a housing.
The method includes combining an RF component and at least one skullpet of a skullpet array.
The method includes coupling an RF component and at least one skullpet of a skullpet array via a housing.
The method includes configuring the housing to be removably coupled with the control device, and the RF component is coupled with the control device.
The method couples a vacuum component with at least one of a skull pet device and a housing, and couples at least one of the skull pet device, the skull pet array and the housing with a radio frequency (RF) component. Including.
The method includes configuring at least one of the skull pet device and the housing to include a low pressure zone.
The method includes configuring at least one of the skull pet device, the skull pet array, and the housing to receive energy from the RF component.
The energy includes at least one of thermal energy, vibration energy, rotational energy, and acoustic energy.
The target site includes the recipient site, and the incision skin pixel creates a skin defect at the recipient site.
The target site includes a donor site, and multiple incision skin pixels are captured at the donor site.
The target site includes the recipient site, and the incision skin pixel creates a skin defect at the recipient site.
The method includes configuring the adhesive substrate to acquire a plurality of incision skin pixels at the donor site and to transfer the plurality of incision skin pixels to the recipient site.
The method includes configuring the adhesive substrate to maintain the relative position of the plurality of incision skin pixels while being transferred to and applied to the recipient site.
The method includes configuring an adhesive substrate to apply an incision skin pixel to a skin defect at a recipient site.
The method includes configuring the adhesive substrate to align the incision skin pixel with the skin defect at the recipient site.
The method includes configuring the adhesive substrate to insert each incision skin pixel into a corresponding skin defect at the recipient site.
The method includes configuring at least one bandage to be applied to the target site.
The method includes configuring at least one bandage to apply a force to close the target site.
The method includes configuring at least one bandage to apply a directional force to control the direction of closure at the target site.
The at least one bandage includes a first bandage configured to be applied to the donor site.
The at least one bandage includes a second bandage configured to be applied to the recipient site.
The method configures a scalpel device to transfer a load to the underlying skin surface containing the target site, and the skin pixel is dissected by the application of the load.
The method configures the sculpture array to transfer a load to the underlying skin surface containing the target site, and the skin pixels are dissected by the application of the load.
The method includes configuring the skull pet device to be disposable.
The method includes configuring the scalpet device to perform at least one of cleaning, disinfection, and sterilization.
The method includes configuring a template for placement at a target site.
The method includes configuring the skull pet device to align with the template.
The method includes configuring the skull pet array to align with the template.
The template is on the target skin surface.
The template includes an indicator on the skin surface of the target site.
The template is configured for placement at the target site and includes a guide plate that includes holes arranged in a pattern.
The skull pet array is removably coupled to the skull pet device.
The skull pet array is disposable.
The shape of each skull pet of the skull pet array is an ellipse.
The shape of each skull pet of the skull pet array is circular.
The shape of each skull pet in the skull pet array is semicircular.
The shape of each skull pet of the skull pet array is one of square, rectangular and flat.
Each skull pet of at least one skull pet includes a slope.
Each skull pet of the plurality of skull pets includes at least one pointed surface.
Each skull pet of the plurality of skull pets includes at least one needle.
The at least one needle includes at least one needle including a plurality of tips.
The method configures the sculpture array to generate an incision skin pixel using at least one of a puncture force, an impact force, and a rotational force.
The method includes configuring a sculpture array to generate an incision skin pixel using radio frequency (RF) energy. .
The method includes configuring a sculpture array to generate an incision skin pixel using vibrational energy. .
At least one skull pet of the skull pet array includes a through orifice.
At least one radial dimension of each scalpet of the scalpet array is in the range of approximately 0.5 millimeters to 4.0 millimeters.
The method includes configuring a positioning guide plate as a template for a target site, the guide plate including holes arranged in a pattern.
The method includes configuring the skull pet array to align with the holes in the guide plate.
The method includes configuring a sculpture array to be applied to a donor site through a hole in a guide plate, wherein a plurality of skin pixels are incised.
The method includes configuring a sculptpet array to be applied to a recipient site through a hole in a guide plate, wherein a plurality of skin defects are generated.
Target sites include donor sites and recipient sites.
A plurality of incision skin pixels and a plurality of skin defects are generated according to the pattern.
The method includes configuring the adhesive substrate to acquire a plurality of incision skin pixels at the donor site and to transfer the plurality of incision skin pixels to the recipient site.
The method includes configuring the adhesive substrate to maintain the relative position of the plurality of incision skin pixels while being transferred to and applied to the recipient site.
The method includes configuring a skull pet array to be applied directly to a donor site through a hole to incise a skin pixel.
The method includes configuring a skull pet array to be applied directly to a recipient site through a hole to generate a skin defect.
The method includes configuring the guide plate to be at least one of adhesive, rigid, semi-rigid, flexible, non-flexible, and non-variable.
The method includes configuring the guide plate to include at least one of a metallic material, a plastic material, a polymer material, and a membranous material.
The method includes configuring the guide plate to transmit a load to the skin surface of at least one of the donor site and the recipient site.
The method includes configuring the guide plate to be placed directly on the skin surface at the target site.
The method includes configuring the guide plate to extrude a plurality of incision skin pixels.
The plurality of skin pixels are pushed through the hole in response to the applied load.
The plurality of skin pixels are pushed through the cut skin surface according to the applied load.
The method includes configuring at least one of a housing, a skull pet device, and a skull pet array for use with a cutting member.
The incision skin pixel is traversed by the cutting member.
The method includes configuring the adhesive substrate to obtain an incision skin pixel.
The method includes configuring the cutting member to be coupled with the frame. The frame is coupled to a guide plate, and the guide plate is configured as a guide for the skull pet device.
The method includes configuring an adhesive substrate to be coupled to at least one of a frame and a guide plate.
The incision skin pixel includes a hair follicle.
The method includes configuring a skin defect to cause angiogenesis in an incised skin pixel inserted at a recipient site. .
The method includes configuring a skin defect to cause a wound healing response in an incised skin pixel inserted at a recipient site.
Embodiments include a method that includes configuring a housing to include a skull pet device. The method includes configuring a scalpel device to include a scalpel array having a plurality of scalpels arranged in a pattern. The plurality of skull pets are configured to exit the housing and generate a plurality of incision skin pixels at the target site.
Embodiments include configuring a housing to include a sculpture device, and configuring the sculpture device to include a sculpture array including a plurality of sculptures arranged in a pattern, wherein The scalpet is configured to exit the housing and generate a plurality of incision skin pixels at the target site.
Embodiments include a method that includes configuring a control device to have a proximal end and a distal end. The proximal end includes an actuator. The method includes configuring the housing to include a skull pet device and to be removably coupled to the distal end of the control device. The method includes configuring a scalpel device to include a scalpel array having a plurality of scalpels arranged in a pattern. The plurality of scalpets are configured to exit the housing when exiting to create a plurality of incision skin pixels at the target site.
Embodiments include configuring the control device to include a proximal end and a distal end, the proximal end including an actuator, a housing, a sculpture device, and a distal end of the control device Configuring to be removably coupled and configuring the scalpet device to include a scalpel array that includes a plurality of scalpets arranged in a pattern when the plurality of scalpets exit And exiting the housing to generate a plurality of incision skin pixels at the target site.

  Throughout the description, words such as “comprise” and “comprising” are not exclusive or exhaustive unless the context explicitly requires otherwise. , In a comprehensive sense, ie in the sense of “including but not limited to”. Words using the singular or plural number also include the plural or singular number respectively. Furthermore, the terms “in this specification”, “below”, “above”, “below”, and like words when used in this application refer to the entire application and to specific parts of the application. It does not point to. When the word “or” is used with reference to a list of two or more items, the word covers all of the following interpretations of the word; any of the items in the list, any of the items in the list Any combination of all and list items.

  The above description of embodiments is not intended to be exhaustive or to limit the systems and methods to the precise forms disclosed. For purposes of illustration, specific embodiments and examples of medical devices and methods are described herein, but as those skilled in the art will recognize, within the scope of the systems and methods. Various equivalent changes are possible. The teachings on medical devices and methods provided herein can be applied not only to the systems and methods described above, but also to other systems and methods.

  The elements or acts of the various embodiments described above can be combined to provide further embodiments. These and other changes can be made to the medical device and method in view of the above detailed description.

  In general, in the following claims, the terms used should not be construed as limiting the medical devices and methods and corresponding systems and methods to the specific embodiments disclosed in the specification and claims, It should be construed to encompass all systems operating under the claims. Accordingly, the medical devices and methods and corresponding systems and methods are not limited by the present disclosure, but instead the scope is completely determined by the claims.

  Although certain aspects of the medical devices and methods and corresponding systems and methods are presented below in certain claim forms, the inventors have described the medical devices and methods in any claim form and Various aspects of corresponding systems and methods are envisioned. Accordingly, the inventors reserve the right to add further claims after filing the present application to pursue additional claim forms for other aspects of the medical device and method and corresponding system and method. .

Claims (411)

A housing configured to contain a skull pet device;
The sculptpet device having a substrate and a sculpture array, the sculpture array including a plurality of sculptures arranged in a configuration on the substrate, the substrate and the plurality of sculptures from the housing An apparatus comprising: the skull pet device configured to exit and enter the housing, the plurality of skull pets configured to generate a plurality of incision skin pixels at a target site upon exit.   The apparatus of claim 1, wherein the housing is configured to be removably coupled to a receiver.   The apparatus of claim 2, wherein the receiver is a component of a control device.   4. The apparatus of claim 3, wherein the control device includes a proximal end and a distal end, the proximal end includes a drive mechanism, and the distal end includes the receiver.   The apparatus of claim 4, wherein the sculpture array is configured to exit in response to activation of the drive mechanism.   The apparatus of claim 4, wherein the proximal end of the control device is configured to be hand held.   The apparatus of claim 4, wherein the sculpture device is configured such that the sculpture array exits the sculpture device and enters back into the sculpture device in response to activation of the drive mechanism.   The apparatus of claim 4, wherein the sculpture device is configured such that the sculpture array exits the sculpture device in response to activation of the drive mechanism.   9. The apparatus of claim 8, wherein the sculpture device is configured such that the sculpture array enters the sculpture device back upon the release of the drive mechanism.   The apparatus of claim 4, wherein the control device is configured to be disposable.   The apparatus of claim 4, wherein the control device is configured to perform at least one of cleaning, disinfection, and sterilization.   The apparatus of claim 1, comprising an adhesive substrate configured to acquire the plurality of incision skin pixels.   The apparatus of claim 12, wherein the scalpet device is configured to include the adhesive substrate.   The apparatus of claim 12, wherein the housing is configured to include the adhesive substrate.   The apparatus of claim 12, wherein the adhesive substrate comprises a flexible substrate.   The apparatus of claim 12, wherein the adhesive substrate comprises a quasi-porous membrane.   The apparatus of claim 1 comprising a vacuum component.   The apparatus of claim 17, wherein the vacuum component is coupled to the housing.   The apparatus of claim 17, wherein the vacuum component is coupled to the scalpel device.   The apparatus of claim 17, wherein the vacuum component is coupled to the scalpet device via the housing.   The apparatus of claim 17, wherein the vacuum component is configured to create a low pressure zone in at least one of the sculpture device and the control device.   The apparatus of claim 21, wherein the low pressure zone is configured to remove the plurality of incision skin pixels.   The apparatus of claim 17, wherein the housing is configured to be removably coupled with a control device and the vacuum component is coupled with the control device.   The apparatus of claim 1, comprising a radio frequency (RF) component.   25. The apparatus of claim 24, wherein the RF component is configured to provide thermal energy to at least one of the sculpture device and the sculpture array.   25. The apparatus of claim 24, wherein the RF component is configured to provide vibration energy to at least one of the sculpture device and the sculpture array.   25. The apparatus of claim 24, wherein the RF component is configured to provide rotational energy to at least one of the sculpture device and the sculpture array.   25. The apparatus of claim 24, wherein the RF component is configured to provide acoustic energy to at least one of the sculpture device and the sculpture array.   The apparatus of claim 24, wherein the RF component is coupled to the housing.   The apparatus of claim 24, wherein the RF component is coupled to the sculpture device.   The apparatus of claim 24, wherein the RF component is coupled to the sculpture device via the housing.   25. The apparatus of claim 24, wherein the RF component is coupled to the sculpture array.   25. The apparatus of claim 24, wherein the RF component is coupled to the sculpture array via the housing.   25. The apparatus of claim 24, wherein the RF component is coupled to at least one skullpet of the skullpet array.   25. The apparatus of claim 24, wherein the RF component is coupled to the at least one skullpet of the skullpet array via the housing.   25. The apparatus of claim 24, wherein the housing is configured to be removably coupled with a control device, and the RF component is coupled with the control device. A vacuum component coupled to at least one of the skull pet device and the housing;
The apparatus of claim 1, comprising: a radio frequency (RF) component coupled to at least one of the skull pet device, the skull pet array, and the housing.   38. The apparatus of claim 37, wherein the vacuum component is configured to create a low pressure zone in at least one of the skull pet device and the housing.   38. The apparatus of claim 37, wherein the RF component is configured to provide energy to at least one of the sculpture device, the sculpture array, and the housing.   40. The apparatus of claim 39, wherein the energy includes at least one of thermal energy, vibration energy, rotational energy, and acoustic energy.   The apparatus of claim 1, wherein the target site includes a recipient site, and the incised skin pixel generates a skin defect in the recipient site.   The apparatus of claim 1, wherein the target site includes a donor site, and the plurality of incision skin pixels are incorporated at the donor site.   43. The apparatus of claim 42, wherein the target site includes a recipient site, and the incised skin pixel generates a skin defect at the recipient site.   44. The apparatus of claim 43, comprising an adhesive substrate configured to obtain the plurality of incision skin pixels at the donor site and to transfer the plurality of incision skin pixels to the recipient site.   45. The apparatus of claim 44, wherein the adhesive substrate is configured to maintain a relative position of the plurality of incision skin pixels while being transferred to and applied to the recipient site.   45. The apparatus of claim 44, wherein the adhesive substrate is configured to apply the incision skin pixel to the skin defect at the recipient site.   45. The apparatus of claim 44, wherein the adhesive substrate is configured to align the incision skin pixel with the skin defect at the recipient site.   48. The apparatus of claim 47, wherein the adhesive substrate is configured to insert each incision skin pixel into a corresponding skin defect at the recipient site.   44. The apparatus of claim 43, comprising at least one bandage configured to be applied to the target site.   50. The apparatus of claim 49, wherein the at least one bandage is configured to apply a force to close the target site.   50. The apparatus of claim 49, wherein the at least one bandage is configured to apply a directional force to control a closing direction at the target site.   52. The apparatus of claim 51, wherein the at least one bandage includes a first bandage configured to be applied to the donor site.   52. The apparatus of claim 51, wherein the at least one bandage includes a second bandage configured to be applied to the recipient site.   The apparatus of claim 1, wherein the scalpel device is configured to transfer a load to a lower skin surface including the target site, and the skin pixel is incised upon application of the load.   The apparatus of claim 1, wherein the sculpture array is configured to transfer a load to a lower skin surface including the target site, and the skin pixel is incised by application of the load.   The apparatus of claim 1, wherein the skull pet device is configured to be disposable.   The apparatus of claim 1, wherein the skull pet device is configured to perform at least one of cleaning, disinfection, and sterilization.   The apparatus of claim 1, comprising a template configured to be placed at the target site.   59. The apparatus of claim 58, wherein the skull pet device is configured to align with the template.   59. The apparatus of claim 58, wherein the skull pet array is configured to align with the template.   59. The apparatus of claim 58, wherein the template is on a skin surface of the target site.   64. The apparatus of claim 61, wherein the template includes an indicator on the skin surface of the target site.   62. The apparatus of claim 61, wherein the template includes a guide plate configured to be disposed at the target site and including holes disposed in a pattern.   The apparatus of claim 1, wherein the sculpture array is removably coupled to the sculpture device.   The apparatus of claim 1, wherein the skull pet array is configured to be disposable.   The apparatus of claim 1, wherein the shape of each sculpture of the sculpture array is an ellipse.   The apparatus according to claim 1, wherein each sculpture of the sculpture array is circular.   The apparatus of claim 1, wherein the shape of each sculpture of the sculpture array is semicircular.   The apparatus of claim 1, wherein the shape of each sculpture in the sculpture array is one of a square, a rectangle, and a flat.   The apparatus of claim 1, wherein each of the at least one scalpet includes a slope.   The apparatus of claim 1, wherein each skullpet of the plurality of skullpets includes at least one pointed surface.   The apparatus of claim 1, wherein each of the plurality of scalpets includes at least one needle.   The apparatus of claim 72, wherein the at least one needle includes at least one needle including a plurality of tips.   The apparatus of claim 1, wherein the sculpture array generates the incision skin pixel using at least one of a piercing force, an impact force, and a rotational force.   The apparatus of claim 1, wherein the sculpture array uses radio frequency (RF) energy to generate the incision skin pixel.   The apparatus of claim 1, wherein the sculpture array uses vibrational energy to generate the incision skin pixel.   The apparatus of claim 1, wherein at least one sculpture of the sculpture array includes a through orifice.   The apparatus of claim 1, wherein at least one radial dimension of each scalpet of the scalpet array is in a range of approximately 0.5 millimeters to 4.0 millimeters.   The apparatus of claim 1, comprising a guide plate configured to be placed as a template for the target site, the guide plate including holes arranged in a pattern.   80. The apparatus of claim 79, wherein the sculpture array is configured to align with the holes in the guide plate.   80. The apparatus of claim 79, wherein the sculpture array is applied to a donor site through the holes in the guide plate and the plurality of skin pixels are incised.   82. The apparatus of claim 81, wherein the sculpture array is applied to a recipient site through the holes in the guide plate and a plurality of skin defects are generated.   83. The apparatus of claim 82, wherein the target site includes the donor site and the recipient site.   83. The apparatus of claim 82, wherein the plurality of incision skin pixels and the plurality of skin defects are generated according to the pattern.   83. The apparatus of claim 82, comprising an adhesive substrate configured to acquire the plurality of incision skin pixels at the donor site and to transfer the plurality of incision skin pixels to the recipient site.   86. The apparatus of claim 85, wherein the adhesive substrate is configured to maintain the relative position of the plurality of incision skin pixels while being transferred to and applied to the recipient site.   83. The apparatus of claim 82, wherein the sculpture array is applied directly to the donor site through the hole and the skin pixel is incised.   83. The device of claim 82, wherein the sculpture array is applied directly to the recipient site through the hole and the skin defect is created.   80. The apparatus of claim 79, wherein the guide plate is at least one of adhesive, rigid, semi-rigid, flexible, non-flexible, and non-variable.   80. The apparatus of claim 79, wherein the guide plate comprises at least one of a metallic material, a plastic material, a polymer material, and a membranous material.   80. The apparatus of claim 79, wherein the guide plate is configured to transmit a load to a skin surface of at least one of the donor site and the recipient site.   80. The apparatus of claim 79, wherein the guide plate is placed directly on the skin surface of the target site.   94. The apparatus of claim 92, wherein the guide plate is configured to extrude the plurality of incision skin pixels.   94. The apparatus of claim 93, wherein the plurality of skin pixels are pushed through the hole in response to an applied load.   94. The apparatus of claim 93, wherein the plurality of skin pixels are extruded through the incised skin surface in response to an applied load.   The apparatus of claim 1, comprising a cutting member.   99. The apparatus of claim 96, wherein the incision skin pixel is traversed by the cutting member.   98. The apparatus of claim 97, comprising an adhesive substrate configured to acquire the incision skin pixel.   99. The apparatus of claim 98, wherein the cutting member is coupled to a frame.   100. The apparatus of claim 99, wherein the frame is coupled to a guide plate, and the guide plate is configured as a guide for the skull pet device.   100. The apparatus of claim 99, wherein the adhesive substrate is coupled to at least one of the frame and the guide plate.   The apparatus of claim 1, wherein the incision skin pixel comprises a hair follicle.   The apparatus of claim 1, wherein the skin defect is configured to cause angiogenesis in the incised skin pixel inserted into the recipient site.   The apparatus of claim 1, wherein the skin defect is configured to cause a wound healing response in the incised skin pixel inserted in the recipient site. A housing containing a skull pet device;
The skull pet device having a skull pet array that includes a plurality of skull pets arranged in a pattern, wherein the plurality of skull pets exit the housing to generate a plurality of incision skin pixels at a target site. An apparatus comprising: the skull pet device. A control device including a proximal end and a distal end, wherein the proximal end includes a drive mechanism and the distal end includes a receiver;
A sculpture device configured to be removably coupled to the receiver of the control device, the sculpture device including a substrate and a sculpture array, wherein the sculpture array is on the substrate. A plurality of scalpets disposed, wherein the substrate and the plurality of scalpets are configured to exit in response to activation of the drive mechanism, and when the plurality of scalpets exit, a plurality of incision skins at a target site A system comprising: a skull pet device configured to generate pixels.   107. The system of claim 106, wherein the proximal end of the control device is configured to be hand held.   107. The system of claim 106, wherein the target site includes a recipient site, and the incised skin pixel generates a skin defect at the recipient site.   107. The system of claim 106, wherein the target site includes a donor site and the plurality of incision skin pixels are incorporated at the donor site.   110. The system of claim 109, wherein the target site includes a recipient site, and the incision skin pixel generates a skin defect at the recipient site.   111. The system of claim 110, comprising an adhesive substrate configured to acquire the plurality of incision skin pixels at the donor site and to transfer the plurality of incision skin pixels to the recipient site.   112. The system of claim 111, wherein the adhesive substrate is configured to maintain the relative position of the plurality of incision skin pixels while being transferred to and applied to the recipient site.   112. The system of claim 111, wherein the adhesive substrate is configured to apply the incision skin pixel to the skin defect at the recipient site.   112. The system of claim 111, wherein the adhesive substrate is configured to align the incision skin pixel with the skin defect at the recipient site.   115. The system of claim 114, wherein the adhesive substrate is configured to insert each incision skin pixel into a corresponding skin defect at the recipient site.   111. The system of claim 110, comprising at least one bandage configured to be applied to the target site.   117. The system of claim 116, wherein the at least one bandage is configured to apply a force to close the target site.   117. The system of claim 116, wherein the at least one bandage is configured to apply a directional force to control a closing direction at the target site.   119. The system of claim 118, wherein the at least one bandage includes a first bandage configured to be applied to the donor site.   119. The system of claim 118, wherein the at least one bandage includes a second bandage configured to be applied to the recipient site.   107. The system of claim 106, comprising an adhesive substrate configured to acquire the plurality of incision skin pixels.   122. The system of claim 121, wherein the sculpture device is configured to include the adhesive substrate.   122. The system of claim 121, wherein the adhesive substrate comprises a flexible substrate.   122. The system of claim 121, wherein the adhesive substrate comprises a semi-porous membrane.   107. The system of claim 106, wherein the sculpture device is configured to cause the sculpture array to exit the sculpture device and back into the sculpture device in response to activation of the drive mechanism.   107. The system of claim 106, wherein the sculpture device is configured such that the sculpture array exits the sculpture device in response to activation of the drive mechanism.   127. The system of claim 126, wherein the sculpture device is configured to cause the sculpture array to enter the sculpture device back upon the release of the drive mechanism.   107. The system of claim 106, wherein the sculpture device is configured to transfer a load to a lower skin surface including the target site, and the skin pixel is dissected by application of the load.   107. The system of claim 106, wherein the sculpture array is configured to transfer a load to an underlying skin surface that includes the target site, and wherein the skin pixel is dissected upon application of the load.   107. The system of claim 106, wherein the skull pet device is configured to be disposable.   107. The system of claim 106, wherein the skull pet device is configured to perform at least one of cleaning, disinfection, and sterilization.   107. The system of claim 106, wherein the control device is configured to be disposable.   107. The system of claim 106, wherein the control device is configured to perform at least one of cleaning, disinfection, and sterilization.   107. The system of claim 106, comprising a template configured to be deployed at the target site.   135. The system of claim 134, wherein the skull pet device is configured to align with the template.   137. The system of claim 134, wherein the sculptpet array is configured to align with the template.   135. The system of claim 134, wherein the template is on a skin surface of the target.   138. The system of claim 137, wherein the template includes an indicator on the skin surface of the target site.   138. The system of claim 137, wherein the template includes a guide plate configured to be disposed at the target site and including holes disposed in a pattern.   107. The system of claim 106, wherein the sculpture array is removably coupled to the sculpture device.   107. The system of claim 106, wherein the skull pet array is configured to be disposable.   107. The system of claim 106, wherein each sculpture of the sculpture array is elliptical.   107. The system of claim 106, wherein each sculpture of the sculpture array is circular.   107. The system of claim 106, wherein each sculpture of the sculpture array is semi-circular.   107. The system of claim 106, wherein the shape of each sculpture in the sculpture array is one of square, rectangular and flat.   107. The system of claim 106, wherein each scalpet of the at least one scalpet includes a bevel.   107. The system of claim 106, wherein each skullpet of the plurality of skullpets includes at least one pointed surface.   107. The system of claim 106, wherein each scalpet of the plurality of scalpets includes at least one needle.   149. The system of claim 148, wherein the at least one needle includes at least one needle that includes a plurality of tips.   107. The system of claim 106, wherein the skull pet array generates the incision skin pixel using at least one of a puncture force, an impact force, and a rotational force.   107. The system of claim 106, wherein the sculpture array uses radio frequency (RF) energy to generate the incision skin pixel.   107. The system of claim 106, wherein the sculpture array uses vibrational energy to generate the incision skin pixel.   107. The system of claim 106, wherein at least one skullpet of the skullpet array includes a through orifice.   107. The system of claim 106, wherein at least one radial dimension of each scalpet of the scalpet array is in the range of approximately 0.5 millimeters to 4.0 millimeters.   107. The system of claim 106, comprising a vacuum component.   The system of claim 155, wherein the vacuum component is coupled to the control device.   165. The system of claim 155, wherein the vacuum component is coupled to the scalpel device.   165. The system of claim 155, wherein the vacuum component is coupled to the sculpture device via the control device.   166. The system of claim 155, wherein the vacuum component is configured to create a low pressure zone in at least one of the sculpture device and the control device.   160. The system of claim 159, wherein the low pressure zone is configured to retrieve the plurality of incision skin pixels.   107. The system of claim 106, comprising a radio frequency (RF) component.   164. The system of claim 161, wherein the RF component is configured to provide thermal energy to at least one of the sculpture device, the sculpture array, and the control device.   164. The system of claim 161, wherein the RF component is configured to provide vibrational energy to at least one of the sculpture device, the sculpture array, and the control device.   164. The system of claim 161, wherein the RF component is configured to provide rotational energy to at least one of the sculpture device, the sculpture array, and the control device.   163. The system of claim 161, wherein the RF component is configured to provide acoustic energy to at least one of the sculpture device, the sculpture array, and the control device.   164. The system of claim 161, wherein the RF component is coupled to the control device.   164. The system of claim 161, wherein the RF component is coupled to the sculpture device.   164. The system of claim 161, wherein the RF component is coupled to the sculpture device via the control device.   164. The system of claim 161, wherein the RF component is coupled to the sculpture array.   164. The system of claim 161, wherein the RF component is coupled to the sculpture array via the control device.   164. The system of claim 161, wherein the RF component is coupled to at least one scalpet of the scalpet array.   164. The system of claim 161, wherein the RF component is coupled to the at least one scalpet of the scalpet array via the control device. A vacuum component coupled to at least one of the skull pet device and the control device;
107. The system of claim 106, comprising a radio frequency (RF) component coupled to at least one of the sculpture device, the sculpture array, and the control device.   178. The system of claim 173, wherein the vacuum component is configured to create a low pressure zone in at least one of the skull pet device and the control device.   178. The system of claim 173, wherein the RF component is configured to provide energy to at least one of the sculpture device, the sculpture array, and the control device.   175. The system of claim 175, wherein the energy includes at least one of thermal energy, vibration energy, rotational energy, and acoustic energy.   107. The system of claim 106, comprising a guide plate configured for placement as a template for the target site, the guide plate including holes arranged in a pattern.   178. The system of claim 177, wherein the sculptpet array is configured to align with the holes in the guide plate.   178. The system of claim 177, wherein the sculpture array is applied to a donor site through the hole in the guide plate and the plurality of skin pixels are incised.   179. The system of claim 179, wherein the sculpture array is applied to a recipient site through the holes in the guide plate and a plurality of skin defects are generated.   181. The system of claim 180, wherein the target site includes the donor site and the recipient site.   181. The system of claim 180, wherein the plurality of incision skin pixels and the plurality of skin defects are generated according to the pattern.   181. The system of claim 180, comprising an adhesive substrate configured to obtain the plurality of incision skin pixels at the donor site and to transfer the plurality of incision skin pixels to the recipient site.   184. The system of claim 183, wherein the adhesive substrate is configured to maintain a relative position of the plurality of incision skin pixels while being transferred to and applied to the recipient site.   181. The system of claim 180, wherein the sculpture array is applied directly to the donor site through the hole and the skin pixel is incised.   181. The system of claim 180, wherein the sculpture array is applied directly to the recipient site through the hole and the skin defect is created.   178. The system of claim 177, wherein the guide plate is at least one of adhesive, rigid, semi-rigid, flexible, non-flexible, and non-variable.   180. The system of claim 177, wherein the guide plate comprises at least one of a metallic material, a plastic material, a polymer material, and a membranous material.   178. The system of claim 177, wherein the guide plate is configured to convey a load to a skin surface of at least one of the donor site and the recipient site.   178. The system of claim 177, wherein the guide plate is placed directly on the skin surface of the target site.   191. The system of claim 190, wherein the guide plate is configured to extrude the plurality of incision skin pixels.   191. The system of claim 191, wherein the plurality of skin pixels are pushed through the hole in response to an applied load.   191. The system of claim 191, wherein the plurality of skin pixels are extruded through the incised skin surface in response to an applied load.   107. The system of claim 106, comprising a cutting member.   195. The system of claim 194, wherein the incision skin pixel is traversed by the cutting member.   196. The system of claim 195, comprising an adhesive substrate configured to acquire the incision skin pixel.   196. The system of claim 196, wherein the cutting member is coupled to a frame.   197. The system of claim 197, wherein the frame is coupled to a guide plate, and the guide plate is configured as a guide for the scalpel device.   199. The system of claim 197, wherein the adhesive substrate is coupled to at least one of the frame and the guide plate.   107. The system of claim 106, wherein the incision skin pixel comprises a hair follicle.   107. The system of claim 106, wherein the skin defect is configured to cause angiogenesis in the incised skin pixel inserted at the recipient site.   107. The system of claim 106, wherein the skin defect is configured to cause a wound healing response in the incised skin pixel inserted at the recipient site. A control device;
A sculpture device removably coupled to the control device, the sculpture device including a sculpture array having a plurality of sculptures arranged in a pattern, wherein the plurality of sculptures are activated by the control device A system comprising: a scalpel device configured to enter and exit in response to generation and to generate a plurality of incision skin pixels at a target site. A control device having a drive mechanism;
A sculpture device configured to be removably coupled to the control device, the sculpture device including a substrate and a sculpture array, wherein the sculpture array is arranged in a pattern on the substrate. A plurality of scalpets, wherein the substrate and the plurality of scalpets are configured to perform at least one of exiting and entering in response to activation of the drive mechanism, and when the plurality of scalpets exit A system comprising: a scalpel device configured to generate a plurality of incision skin pixels at a target site. A housing configured to contain a skull pet device;
The scalpet device having a substrate and a sculpture array, the sculpture array including a plurality of sculptures arranged in a configuration on the substrate, the substrate and the plurality of sculptures from the housing The skull pet device configured to exit and to enter the housing, the plurality of skull pets configured to generate a plurality of incision skin pixels at a target site upon exit;
A vacuum component configured to create a low pressure zone next to the skull pet device.   206. The system of claim 205, wherein the vacuum component is coupled to the housing.   206. The system of claim 205, wherein the vacuum component is coupled to the scalpet device.   206. The system of claim 205, wherein the vacuum component is coupled to the skull pet device via the housing.   206. The system of claim 205, wherein the vacuum component is configured to create the low pressure zone within the housing.   206. The system of claim 205, wherein the low pressure zone is configured to retrieve the plurality of incision skin pixels.   206. The system of claim 205, wherein the housing is configured to be removably coupled with a receiver.   The system of claim 211, wherein the receiver is a component of a control device.   223. The system of claim 212, wherein the control device includes a proximal end and a distal end, the proximal end includes a drive mechanism, and the distal end includes the receiver.   213. The system of claim 213, wherein the sculptpet array is configured to exit in response to activation of the drive mechanism.   213. The system of claim 213, wherein the proximal end of the control device is configured to be hand held.   223. The system of claim 213, wherein the sculpture device is configured to cause the sculpture array to exit the sculpture device and enter the sculpture device in response to activation of the drive mechanism.   213. The system of claim 213, wherein the sculpture device is configured such that the sculpture array exits the sculpture device in response to activation of the drive mechanism.   218. The system of claim 217, wherein the sculpture device is configured to cause the sculpture array to enter the sculpture device back upon the release of the drive mechanism.   213. The system of claim 213, wherein the control device is configured to be disposable.   213. The system of claim 213, wherein the control device is configured to perform at least one of cleaning, disinfection, and sterilization.   206. The system of claim 205, comprising an adhesive substrate configured to acquire the plurality of incision skin pixels.   223. The system of claim 221, wherein the sculpture device is configured to include the adhesive substrate.   223. The system of claim 221, wherein the housing is configured to include the adhesive substrate.   223. The system of claim 221, wherein the adhesive substrate comprises a flexible substrate.   223. The system of claim 221, wherein the adhesive substrate comprises a quasiporous membrane.   206. The system of claim 205, comprising a radio frequency (RF) component.   226. The system of claim 226, wherein the RF component is configured to provide thermal energy to at least one of the sculpture device and the sculpture array.   226. The system of claim 226, wherein the RF component is configured to provide vibration energy to at least one of the sculpture device and the sculpture array.   226. The system of claim 226, wherein the RF component is configured to provide rotational energy to at least one of the sculpture device and the sculpture array.   226. The system of claim 226, wherein the RF component is configured to provide acoustic energy to at least one of the sculpture device and the sculpture array.   226. The system of claim 226, wherein the RF component is coupled to the housing.   226. The system of claim 226, wherein the RF component is coupled to the scalpet device.   226. The system of claim 226, wherein the RF component is coupled to the skull pet device via the housing.   226. The system of claim 226, wherein the RF component is coupled to the sculpture array.   226. The system of claim 226, wherein the RF component is coupled to the sculpture array via the housing.   226. The system of claim 226, wherein the RF component is coupled to at least one skullpet of the skullpet array.   226. The system of claim 226, wherein the RF component is coupled to the at least one skullpet of the skullpet array via the housing.   227. The system of claim 226, wherein the housing is configured to be removably coupled with a control device and the RF component is coupled with the control device.   206. The system of claim 205, wherein the target site includes a recipient site, and the incised skin pixel generates a skin defect at the recipient site.   206. The system of claim 205, wherein the target site includes a donor site and the plurality of incision skin pixels are incorporated at the donor site.   239. The system of claim 240, wherein the target site includes a recipient site, and the incision skin pixel generates a skin defect at the recipient site.   242. The system of claim 241, comprising an adhesive substrate configured to acquire the plurality of incision skin pixels at the donor site and to transfer the plurality of incision skin pixels to the recipient site.   243. The system of claim 242, wherein the adhesive substrate is configured to maintain a relative position of the plurality of incision skin pixels while being transferred to and applied to the recipient site.   243. The system of claim 242, wherein the adhesive substrate is configured to apply the incision skin pixel to the skin defect at the recipient site.   243. The system of claim 242, wherein the adhesive substrate is configured to align the incision skin pixel with the skin defect at the recipient site.   254. The system of claim 245, wherein the adhesive substrate is configured to insert each incision skin pixel into a corresponding skin defect at the recipient site.   242. The system of claim 241, comprising at least one bandage configured to be applied to the target site.   247. The system of claim 247, wherein the at least one bandage is configured to apply a force to close the target site.   247. The system of claim 247, wherein the at least one bandage is configured to apply a directional force to control a closing direction at the target site.   249. The system of claim 249, wherein the at least one bandage includes a first bandage configured to be applied to the donor site.   249. The system of claim 249, wherein the at least one bandage includes a second bandage configured to be applied to the recipient site.   206. The system of claim 205, wherein the sculpture device is configured to transfer a load to a lower skin surface that includes the target site, and the skin pixel is dissected upon application of the load.   206. The system of claim 205, wherein the sculpture array is configured to transfer a load to an underlying skin surface that includes the target site, and wherein the skin pixel is dissected upon application of the load.   206. The system of claim 205, wherein the skull pet device is configured to be disposable.   206. The system of claim 205, wherein the skull pet device is configured to perform at least one of cleaning, disinfection, and sterilization.   206. The system of claim 205, comprising a template configured to be deployed at the target site.   256. The system of claim 256, wherein the skull pet device is configured to align with the template.   256. The system of claim 256, wherein the skull pet array is configured to align with the template.   256. The system of claim 256, wherein the template is on a skin surface of the target.   259. The system of claim 259, wherein the template includes an indicator on the skin surface of the target site.   259. The system of claim 259, wherein the template includes a guide plate configured to be disposed at the target site and including holes disposed in a pattern.   206. The system of claim 205, wherein the sculpture array is removably coupled to the sculpture device.   206. The system of claim 205, wherein the skull pet array is configured to be disposable.   206. The system of claim 205, wherein each sculpture of the sculpture array is elliptical.   The system of claim 205, wherein the shape of each sculpture in the sculpture array is circular.   206. The system of claim 205, wherein the shape of each sculpture in the sculpture array is semicircular.   The system of claim 205, wherein the shape of each sculpture in the sculpture array is one of square, rectangular and flat.   206. The system of claim 205, wherein each scalpet of the at least one scalpet includes a bevel.   206. The system of claim 205, wherein each scalpet of the plurality of scalpets includes at least one pointed surface.   206. The system of claim 205, wherein each scalpet of the plurality of scalpets includes at least one needle.   276. The system of claim 270, wherein the at least one needle includes at least one needle that includes a plurality of tips.   206. The system of claim 205, wherein the skull pet array generates the incision skin pixel using at least one of a puncture force, an impact force, and a rotational force.   206. The system of claim 205, wherein the sculpture array uses radio frequency (RF) energy to generate the incision skin pixel.   206. The system of claim 205, wherein the sculptpet array uses vibrational energy to generate the incision skin pixel.   206. The system of claim 205, wherein at least one sculpture of the sculpture array includes a through orifice.   206. The system of claim 205, wherein at least one radial dimension of each scalpet of the scalpet array is in a range of approximately 0.5 millimeters to 4.0 millimeters.   206. The system of claim 205, comprising a guide plate configured for placement as a template for the target site, wherein the guide plate includes holes arranged in a pattern.   277. The system of claim 277, wherein the sculpture array is configured to align with the holes in the guide plate.   277. The system of claim 277, wherein the sculpture array is applied to a donor site through the hole in the guide plate and the plurality of skin pixels are incised.   294. The system of claim 279, wherein the sculpture array is applied to a recipient site through the holes in the guide plate and a plurality of skin defects are generated.   290. The system of claim 280, wherein the target site includes the donor site and the recipient site.   290. The system of claim 280, wherein the plurality of incision skin pixels and the plurality of skin defects are generated according to the pattern.   290. The system of claim 280, comprising an adhesive substrate configured to acquire the plurality of incision skin pixels at the donor site and to transfer the plurality of incision skin pixels to the recipient site.   289. The system of claim 283, wherein the adhesive substrate is configured to maintain a relative position of the plurality of incision skin pixels while being transferred to and applied to the recipient site.   290. The system of claim 280, wherein the sculpture array is applied directly to the donor site through the hole and the skin pixel is incised.   290. The system of claim 280, wherein the sculpture array is applied directly to the recipient site through the hole and the skin defect is created.   277. The system of claim 277, wherein the guide plate is at least one of adhesive, rigid, semi-rigid, flexible, non-flexible, and non-variable.   277. The system of claim 277, wherein the guide plate includes at least one of a metallic material, a plastic material, a polymer material, and a membranous material.   277. The system of claim 277, wherein the guide plate is configured to convey a load to a skin surface of at least one of the donor site and the recipient site.   277. The system of claim 277, wherein the guide plate is placed directly on the skin surface of the target site.   290. The system of claim 290, wherein the guide plate is configured to extrude the plurality of incision skin pixels.   292. The system of claim 291, wherein the plurality of skin pixels are pushed through the hole in response to an applied load.   292. The system of claim 291, wherein the plurality of skin pixels are extruded through the incised skin surface in response to an applied load.   206. The system of claim 205, comprising a cutting member.   295. The system of claim 294, wherein the incision skin pixel is traversed by the cutting member.   294. The system of claim 295, comprising an adhesive substrate configured to acquire the incision skin pixel.   296. The system of claim 296, wherein the cutting member is coupled to a frame.   297. The system of claim 297, wherein the frame is coupled to a guide plate, and the guide plate is configured as a guide for the scalpel device.   297. The system of claim 297, wherein the adhesive substrate is coupled to at least one of the frame and the guide plate.   206. The system of claim 205, wherein the incision skin pixel comprises a hair follicle.   206. The system of claim 205, wherein the skin defect is configured to cause angiogenesis in the incised skin pixel inserted at the recipient site.   206. The system of claim 205, wherein the skin defect is configured to cause a wound healing response in the incised skin pixel inserted at the recipient site. A housing containing a skull pet device;
The skull pet device having a skull pet array that includes a plurality of skull pets arranged in a pattern, wherein the plurality of skull pets exit the housing to generate a plurality of incision skin pixels at a target site. And the skull pet device,
A vacuum component configured to create a low pressure zone next to the skull pet device. Disposing a housing including a sculpture device at a target site, the sculpture device including a substrate and a sculpture array, wherein the sculpture array is disposed in a configuration on the substrate. Including
Removing the skull pet array from the housing to the tissue at the target site to generate a plurality of incision skin pixels at the target site;
Returning the skull pet array from the target site into the housing.   305. The method of claim 304, comprising combining the housing and a receiver that is a component of a control device.   306. The method of claim 305, wherein the control device includes a proximal end and a distal end, the proximal end includes a drive mechanism, and the distal end includes the receiver.   307. The method of claim 306, wherein the ejecting includes ejecting the sculpture array in response to activation of the drive mechanism.   307. The method of claim 306, wherein the returning includes returning the sculpture array in response to activation of the drive mechanism.   307. The method of claim 306, wherein the returning includes returning the sculpture array in response to release of the drive mechanism.   307. The method of claim 306, wherein the proximal end of the control device is configured to be hand held.   307. The method of claim 306, comprising moving the scalpet device away from the receiver and positioning the scalpet device.   307. The method of claim 306, comprising at least one of cleaning, disinfection, and sterilization of the control device.   305. The method of claim 304, comprising obtaining the plurality of incision skin pixels using an adhesive substrate.   314. The method of claim 313, wherein the scalpel device includes the adhesive substrate.   314. The method of claim 313, wherein the housing includes the adhesive substrate.   314. The method of claim 313, wherein the adhesive substrate comprises a flexible substrate.   314. The method of claim 313, wherein the adhesive substrate comprises a semi-porous membrane.   305. The method of claim 304, comprising incorporating the plurality of incision skin pixels.   319. The method of claim 318, wherein the taking includes removing the plurality of incision skin pixels.   319. The method of claim 318, wherein the incorporating includes creating a low pressure zone in at least one of the skull pet device and the housing.   343. The method of claim 320, wherein the generation of the low pressure zone includes using a vacuum component.   321. The method of claim 321, wherein the vacuum component is coupled to the housing.   321. The method of claim 321, wherein the vacuum component is coupled to the scalpet device.   321. The method of claim 321, wherein the vacuum component is coupled to the scalpet device via the housing.   321. The method of claim 321, wherein the housing is configured to be removably coupled with a control device and the vacuum component is coupled with the control device.   305. The method of claim 304, wherein the generation of the plurality of incision skin pixels includes providing energy to at least one of the sculpture device, the sculpture array, and the housing.   305. The method of claim 304, wherein providing the energy includes using a radio frequency (RF) component.   327. The method of claim 327, wherein the energy comprises at least one of thermal energy, vibration energy, rotational energy, and acoustic energy.   327. The method of claim 327, wherein the providing of the energy includes providing thermal energy to at least one of the sculpture device and the sculpture array.   327. The method of claim 327, wherein the providing of the energy comprises providing vibrational energy to at least one of the skull pet device and the skull pet array.   327. The method of claim 327, wherein the providing of the energy comprises providing rotational energy to at least one of the sculpture device and the sculpture array.   327. The method of claim 327, wherein the providing of the energy includes providing acoustic energy to at least one of the sculpture device and the sculpture array.   327. The method of claim 327, wherein the RF component is coupled to the housing.   327. The method of claim 327, wherein the RF component is coupled to the scalpet device.   327. The method of claim 327, wherein the RF component is coupled to the sculpture device via the housing.   327. The method of claim 327, wherein the RF component is coupled to the sculpture array.   327. The method of claim 327, wherein the RF component is coupled to the sculpture array via the housing.   327. The method of claim 327, wherein the RF component is coupled to at least one sculpt of the sculpture array.   327. The method of claim 327, wherein the RF component is coupled to the at least one skullpet of the skullpet array via the housing.   327. The method of claim 327, wherein the housing is configured to be removably coupled with a control device and the RF component is coupled with the control device.   305. The method of claim 304, comprising incorporating the plurality of incision skin pixels using a vacuum component, wherein the generation of the plurality of incision skin pixels includes using radio frequency (RF) energy.   341. The method of claim 341, wherein the vacuum component is configured to create a low pressure zone in at least one of the skull pet device and the housing.   348. The method of claim 341, wherein the RF component is configured to provide energy to at least one of the sculpture device, the sculpture array, and the housing.   347. The method of claim 343, wherein the energy includes at least one of thermal energy, vibration energy, rotational energy, and acoustic energy.   305. The method of claim 304, wherein the target site includes a recipient site, and the incision skin pixel generates a skin defect at the recipient site.   305. The method of claim 304, wherein the target site comprises a donor site and the plurality of incision skin pixels are incorporated at the donor site.   347. The method of claim 346, wherein the target site comprises a recipient site and the incision skin pixel generates a skin defect at the recipient site.   347. The method of claim 347, comprising obtaining the plurality of incision skin pixels using an adhesive substrate and transferring the plurality of incision skin pixels to the recipient site.   348. The method of claim 348, wherein the adhesive substrate comprises maintaining a relative position of the plurality of incision skin pixels during the transfer to the recipient site.   348. The method of claim 348, comprising applying the plurality of incision skin pixels from the adhesive substrate to the skin defect at the recipient site.   348. The method of claim 348, comprising aligning the plurality of incision skin pixels with the skin defect of the recipient site using the adhesive substrate.   356. The method of claim 351, comprising inserting each incision skin pixel from the adhesive substrate into a corresponding skin defect in the recipient site.   347. The method of claim 347, comprising applying at least one bandage to the target site.   356. The method of claim 353, wherein applying the at least one bandage includes applying a force to close the target site.   356. The method of claim 353, wherein applying the at least one bandage includes applying a directional force to control a closing direction at the target site.   365. The method of claim 355, wherein applying the at least one bandage comprises applying a first bandage at the donor site.   365. The method of claim 355, wherein applying the at least one bandage comprises applying a second bandage to the recipient site.   Generating the plurality of incision skin pixels includes transferring a load through the scalpet device to a lower skin surface including the target site, wherein the skin pixels are incised by application of the load. Item 304. The method according to Item 304.   Generating the plurality of incision skin pixels includes transferring a load through the sculpture array to a lower skin surface including the target site, wherein the skin pixels are incised by application of the load. Item 304. The method according to Item 304.   305. The method of claim 304, wherein the skull pet device is configured to be disposable.   305. The method of claim 304, wherein the skull pet device is configured to perform at least one of cleaning, disinfection, and sterilization.   305. The method of claim 304, comprising placing a template at the target site.   363. The method of claim 362, comprising aligning the skull pet device with the template.   363. The method of claim 362, comprising aligning the sculpture array with the template.   363. The method of claim 362, wherein the placing comprises placing the template on a skin surface of the target site.   365. The method of claim 365, wherein the template includes an indicator on the skin surface of the target site.   365. The method of claim 365, wherein the template includes a guide plate configured to be disposed at the target site and including holes disposed in a pattern.   305. The method of claim 304, comprising removably coupling the sculpture array to the sculpture device.   305. The method of claim 304, wherein the skull pet array is configured to be disposable.   305. The method of claim 304, wherein the shape of each sculpture in the sculpture array is elliptical.   305. The method of claim 304, wherein the shape of each sculpture in the sculpture array is circular.   305. The method of claim 304, wherein each sculpture of the sculpture array is semi-circular.   305. The method of claim 304, wherein the shape of each sculpture in the sculpture array is one of square, rectangular and flat.   305. The method of claim 304, wherein each scalpet of the plurality of scalpets includes a bevel.   305. The method of claim 304, wherein each scalpet of the plurality of scalpets includes at least one pointed surface.   305. The method of claim 304, wherein each scalpet of the plurality of scalpets includes at least one needle.   377. The method of claim 376, wherein the at least one needle includes at least one needle that includes a plurality of tips.   305. The method of claim 304, wherein the generation of the plurality of incision pixels includes generating using at least one of a piercing force, an impact force, and a rotational force.   305. The method of claim 304, wherein the generation of the plurality of incision pixels includes generating using radio frequency (RF) energy.   305. The method of claim 304, wherein the generation of the plurality of incision pixels includes generating using vibration energy.   305. The method of claim 304, wherein at least one sculpture of the sculpture array includes a through orifice.   305. The method of claim 304, wherein at least one radial dimension of each scalpet of the scalpet array is in the range of approximately 0.5 millimeters to 4.0 millimeters.   305. The method of claim 304, comprising placing a guide plate as a template for the target site, the guide plate comprising holes arranged in a pattern.   383. The method of claim 383, comprising aligning the sculpture array with the holes in the guide plate.   383. The method of claim 383, comprising applying the sculptpet array to a donor site through the hole in the guide plate, wherein the plurality of skin pixels are incised.   385. The method of claim 385, comprising applying the sculpture array to a recipient site through the holes in the guide plate, wherein a plurality of skin defects are generated.   389. The method of claim 386, wherein the target site includes the donor site and the recipient site.   389. The method of claim 386, comprising generating the plurality of incision skin pixels and the plurality of skin defects according to the pattern.   389. The method of claim 386, comprising: obtaining the plurality of incision skin pixels with an adhesive substrate at the donor site; and transferring the plurality of incision skin pixels to the recipient site.   409. The method of claim 389, comprising maintaining a relative position of the plurality of incision skin pixels with the adhesive substrate while being transferred to and applied to the recipient site.   389. The method of claim 386, comprising applying the sculpture array directly to the donor site through the hole, wherein the skin pixel is incised.   392. The method of claim 391, comprising applying the sculpture array directly to the recipient site through the hole, wherein the skin defect is generated.   383. The method of claim 383, wherein the guide plate is at least one of adhesive, rigid, semi-rigid, flexible, non-flexible, and non-variable.   383. The method of claim 383, wherein the guide plate comprises at least one of a metallic material, a plastic material, a polymer material, and a membranous material.   383. The method of claim 383, wherein the guide plate is configured to convey a load to a skin surface of at least one of the donor site and the recipient site.   383. The method of claim 383, comprising placing the guide plate directly on a skin surface of the target site.   396. The method of claim 396, comprising extruding the plurality of incision skin pixels with the guide plate.   The method of claim 397, comprising extruding the plurality of skin pixels through the hole in response to an applied load.   The method of claim 397, comprising extruding the plurality of skin pixels through the incision skin surface in response to an applied load.   305. The method of claim 304, wherein the generation of the plurality of incision pixels includes incision with a cutting member.   405. The method of claim 400, comprising traversing the incision skin pixel with the cutting member.   420. The method of claim 401, comprising obtaining the incision skin pixel with an adhesive substrate.   443. The method of claim 402, wherein the cutting member is coupled to a frame.   443. The method of claim 403, wherein the frame is coupled to a guide plate, and the guide plate is configured as a guide for the scalpel device.   443. The method of claim 403, wherein the adhesive substrate is bonded to at least one of the frame and the guide plate.   305. The method of claim 304, wherein the incision skin pixel comprises a hair follicle.   305. The method of claim 304, comprising using the skin defect to cause angiogenesis in the incised skin pixel inserted into the recipient site.   305. The method of claim 304, comprising using the skin defect to cause a wound healing response in the incised skin pixel inserted at the recipient site. Forming a coupling between a control device and a sculpture device, wherein the control device includes an actuator, the sculpture device including a sculpture array including a plurality of sculptures arranged in a pattern; ,
Aligning the skull pet devices on the target site;
Generating a plurality of incision skin pixels and a plurality of skin defects by exposing the sculpt array to the tissue at the target site, wherein the sculpt array is generated in response to activation of the actuator; Including methods. Disposing a housing at a target site, the housing including a scalpel array including a plurality of scalpets arranged in a pattern;
Delivering the skull pet array to the target site tissue;
Generating a plurality of incision skin pixels at the target site if the target site is a donor site;
If the target site is a recipient site, generating a plurality of skin defects at the target site;
Incorporating the plurality of incision skin pixels. Disposing a housing at a donor site, the housing including a sculpture array including a plurality of sculptures arranged in a pattern;
Removing the skullpet array to tissue at the donor site to generate a plurality of incision skin pixels;
Obtaining the plurality of incision skin pixels at the donor site and transferring the incision skin pixels to a recipient;
Disposing the housing at the recipient site; removing the sculpture array to the recipient site tissue to generate a plurality of skin defects;
Applying the plurality of incision skin pixels to the skin defect at the recipient site.

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