CN107405164A - Pel array formula Medical Devices and method - Google Patents

Abstract

Described is system, apparatus and the method that wherein equipment includes the housing comprising skin graft knife system.Skin graft knife system includes flap knife array, and the flap knife array includes the flap knife set with a pattern.Flap knife can deploy from housing to produce the skin pixels being cut open in target site.Housing is positioned and flap knife array is deployed into the tissue of target site.When target site is donor site, the skin pixels being cut open are generated, and when target site is receptor site, generate defect of skin.Obtain the skin pixels being cut open.

Description

Pel array formula Medical Devices and method

Related application

This application claims the power of the U.S. (US) patent for the Application No. 62/044,060 submitted for 29th in August in 2014 Benefit.

This application claims the rights and interests of the United States Patent (USP) for the Application No. 62/044,078 submitted for 29th in August in 2014.

This application claims the rights and interests of the United States Patent (USP) for the Application No. 62/044,089 submitted for 29th in August in 2014.

This application claims the rights and interests of the United States Patent (USP) for the Application No. 62/044,102 submitted for 29th in August in 2014.

The application is the rights and interests of the United States Patent (USP) of Application No. 61/734,313 for requiring to submit on December 6th, 2012 , the part continuation application of the United States Patent (USP) of the Application No. 14/099,380 submitted on December 6th, 2013.

The application is the rights and interests of the United States Patent (USP) of Application No. 61/288,141 for requiring to submit on December 18th, 2009 , the part continuation application of the United States Patent (USP) of the Application No. 12/972,013 submitted on December 17th, 2010.

The application is that the part of the U.S. (US) patent for the Application No. 14/505,090 submitted on October 2nd, 2014 is continued Application.

Technical field

Embodiment herein is related to medical system, medicine equipment or Medical Devices and therapy, and more Body, it is related to applied to the medicine equipment and therapy that surgical procedure is carried out to burn, defect of skin and hair transplantation.

Background technology

The development of sagging cutis laxa is most apparent from presenting aging process.The lengthy procedure of this life can be early Just become within 10 years obvious and will be worsening in subsequent decades at the 3rd of life.Histological research's table It is bright：Droop stretching, extension or the age-related relaxation of skin are partly due to associated with the reduction of skin tensile strength Progressively dermal atrophy caused by.When combining downward gravity, age-related dermal atrophy will cause skin crust Two-dimensional expansion.The clinical manifestation of this physical histology process is the cutis laxa of redundancy.Most impacted region be head, Neck, upper arm, thigh, chest, lower abdomen and knee position.Most obvious region is head and neck in all areas.At this In region, " the lower jaw dewlap " of " the tom formula " of the protrusion of neck relaxation and face bottom is due to the skin in these regions It is inaesthetic it is sagging caused by.

Plastic surgery operations have been developed to cut off unnecessary relaxation skin.These operations must be used and are typically hidden within Elongated otch around anatomical borders, such as, fold under the ear and scalp for shaping and the breast for breast protuberance (mastopexy).However, some regions of cutis laxa excision are in the aesthetics enhancing of more close skin and operative incision Observability between it is poor compromise.Therefore, due to the observability of operative scar, the skin of knee, thigh and buttocks on upper arm, kneecap Skin redundancy can not be cut off in a usual manner.

This aesthetic lopsided frequency and negative social influence promote the hair of " face lifting " surgical operation Exhibition.Other related plastic surgery operations in different zones are abdominoplasty (belly), mastopexy (breast) and arm Orthopedic (upper arm).Intrinsic unfavorable postoperative pain, scar and the postoperative complication of being characterised by of these surgical operations Risk.Although the aesthetics enhancing of these operations is that huge is permanent to the acceptable compromise of required big operative incision Scar is still the inevitable part of these operations.Therefore, plastic surgeon designs these operations with by huge scar Be hidden under such as hair line (face lifting), breast gauffer (mastopexy) and groin gauffer (abdominoplasty) it Near the anatomical borders of class.However, many otch in these otch are hidden away from cutis laxa position, cut so as to limit The effect of mouth.Such as on kneecap (on preceding) other cutis laxa positions of knee etc due to being difficult and more obvious operative scar phase It is not improvable to trade off and cut off for plastic operation.

In recent years, the electromagnetism Medical Devices for producing reverse thermal gradient (that is, hot Margie) have attempted to perform the operation In the case of skin is become tight and achieve different degrees of success.Now, these electromagnetic equipments are with appropriate cutis laxa Patient in obtain best utilization.Due to the limitation of electromagnetic equipment and the potential side effect of operation, it is therefore desirable to minimally invasive Technology avoids the scar related to operation from forming and carried out to skin the clinical variation of Electromagnetic Heating.For many have with The cutis laxa (neck and face, arm, armpit, thigh, knee, buttocks, belly, BL BUST LINE, mastoptosis) of age correlation For patient, the Partial Resection of excess skin can strengthen the signal portion of conventional cosmetic surgery.

Aesthetics modification what is more important than skin crust is entered to burn and other defects of skin related to wound Row surgical procedure.Great burn is classified by total body surface of burn and by the depth of heat damage. First-degree burn and second-degree burn are treated typically by application external-applied ointment and burn dressing in a manner of No operation.It is deeper Third-degree burn be related to the full thickness heat damage of skin.To these severely injured surgical procedure be related to burn eschar debridement with And the application to lift height graft.

Most commonly any full thickness cutaneous defect as caused by the excision of burn, wound or malignant tumour of skin can lead to Cross and come skin flaps or dermatoplasty using current commercial instrument to close.Two kinds of operation methods are required for obtaining from donor site Take.The use of flap is further restricted by needing to include pedicle of vertebral arch blood supply, and in most cases needs directly to close Close donor site.

Due to immunologic constraint, lift height skin graft operation requires to obtain autologous skin graft, i.e. from same Patient obtains.Generally, the donor site with fire victim is that selection is carried out in non-burn area, and is obtained from the region Take segment thickness skin graft.This operation forms part thickness skin defect inevitably at donor site.The donor portion Position defect is similar with deeper second-degree burn in itself.By the reepithelialization at the position come the typically pain of healing and Some days may be continued.In addition, form thinner and lighter obvious donor site deformity more permanent than surrounding skin.Just For the patient of wide area surface burn, a large amount of acquisitions of skin graft may also be limited to the availability of non-burn area.

Therefore, exist in the aesthstic market of Rapid Expansion for the instrument for aesthetic surgical operation dermostenosis and The demand of operation.Also exist for that can obtain skin graft repeatedly from same donor site while eliminate donor site deformity System, instrument or device and operation demand.

Reference combines

The full content of each patent, patent application and/or the publication mentioned in this manual leads in same degree Cross reference to be incorporated herein, be specifically and individually expressed as leading to just as each single patent, patent application and/or publication Cross reference and be incorporated to like that.

Brief description of the drawings

Fig. 1 shows PAD (pel array formula dermatotome) external member for being arranged on target site according to embodiment.

Fig. 2 is the section according to flap knife pressing mold of the embodiment including flap knife array or equipment.

Fig. 3 is the partial cross section according to flap knife pressing mold of the embodiment including flap knife array or equipment.

Fig. 4 shows adhesiveness film (the adhesiveness base with backing being included in PAD external members according to embodiment Bottom).

Fig. 5 is shown according to embodiment when adhesiveness when PAD external members framework and blade assembly are used together Film (adhesiveness substrate).

Fig. 6 shows the removal of the skin pixels carried out according to embodiment.

Fig. 7 is the crosscutting skin pixels being cut open with removal of the blade carried out by PAD external members according to embodiment Side view.

Fig. 8 is to carry out the isometric of perioperative blade/pixel interaction using PAD external members according to embodiment Surveys view.

Fig. 9 be according to embodiment during being performed the operation using PAD external members (for simplicity, blade is removed) Another view, this view show that the acquired skin pixels or skin graft that have been crosscut and captured before crosscutting but Both skin pixels or skin graft for not being crosscut.

Figure 10 A are that the side view, which shows to be fixed to, to be covered according to the side view of a part for the pel array of embodiment Flap knife on cover plate.

Figure 10 B are according to the side view of a part for the pel array of alternative embodiment, and the side view shows solid Determine to the flap knife in cover plate.

Figure 10 C are the top view according to the skin graft knife plate of embodiment.

Figure 10 D are the close up view according to a part for the skin graft knife plate of embodiment.

Figure 11 A show the example roused according to the roller pixel of embodiment.

Figure 11 B show the example roused according to the roller pixel being assembled on handle of embodiment.

Figure 11 C are depicted according to embodiment for the dermatome of drum type that is used together with skin graft knife plate.

Figure 12 A show the dermatome of drum type being positioned above skin graft knife plate according to embodiment.

Figure 12 B are the alternative view according to the dermatome of drum type being positioned above skin graft knife plate of embodiment.

Figure 13 A are to be applied dermatome of drum type (such as Padgett types dermatotome) in skin graft knife plate according to embodiment The isometric view of top, wherein, adhesiveness film is applied in the drum of dermatome of drum type before being rolled in cover plate The drum.

Figure 13 B be according to the side view of a part for the dermatome of drum type of embodiment, the side view show relative to The blade position of skin graft knife plate.

Figure 13 C are to be shown relatively according to the side view of the part of the dermatome of drum type of embodiment, the side view In the different blade positions of skin graft knife plate.

Figure 13 D are the side view of the dermatome of drum type at another blade position relative to skin graft knife plate according to embodiment Figure.

Figure 13 E are to be illustrated according to the side view of the dermatome of drum type with revolving knife clip of embodiment, the side view By blade clip skin pixels are carried out crosscutting.

Figure 13 F are according to the dermatome of drum type of embodiment and the upward view of skin graft knife plate.

Figure 13 G are according to the dermatome of drum type of embodiment and the front view of skin graft knife plate.

Figure 13 H are according to the dermatome of drum type of embodiment and the rearview of skin graft knife plate.

Figure 14 A show the dermatomic assembling figure with pixel type onlay sleeve (POS) according to embodiment.

Figure 14 B are the dermatomic exploded view with pixel type onlay sleeve (POS) according to embodiment.

Figure 14 C show the dermatomic part with pixel type onlay sleeve (POS) according to embodiment.

Figure 15 A show the slidingtype PAD slided on Padgett type dermatomes of drum type according to embodiment.

Figure 15 B show the group of the slidingtype PAD being arranged on above Padgett type dermatomes of drum type according to embodiment Dress figure.

Figure 16 A show according to embodiment be arranged on Padgett types dermatome of drum type above and with tape punching The slidingtype PAD that template or guide plate are used together.

Figure 16 B are shown to be obtained according to embodiment by Padgett types dermatome of drum type and mounted slidingtype PAD Take skin pixels.

Figure 17 A are shown to make skin graft according to the pixel drum-type of the target site for being applied to skin surface of embodiment The example of knife.

Figure 17 B are shown to make skin graft according to the pixel drum-type of the target site for being applied to skin surface of embodiment The alternative view of a part for knife.

Figure 18 shows the side isometric view of the PAD components according to embodiment.

Figure 19 A show the top perspective view of the PAD components according to embodiment.

Figure 19 B show the face upwarding stereogram of the skin graft knife system being used together with PAD components according to embodiment.

Figure 20 shows the side view of the punching press percussion mechanism according to embodiment.

Figure 21 A are the flattened flap knife array of oscillatory type and the top view of blade apparatus according to embodiment.

Figure 21 B show the flattened flap knife array of oscillatory type and the upward view of blade apparatus according to embodiment.

Figure 21 C are according to embodiment when the array of flap knife, blade, adhesiveness film and adhesiveness backing are assembled into one The close up view of flattened array when rising.

Figure 21 D are the close up view according to the flattened array of the flap knife with infeed mean of embodiment.

Figure 22 shows the dead volume dermal matrix according to embodiment, the dead volume dermal matrix with terms of size with being obtained The similar mode of the skin array graft that takes is by column crosscutting.

Figure 23 is the drum-type array drug delivery device according to embodiment.

Figure 24 A are the side view according to the pin array drug delivery device of embodiment.

Figure 24 B are the top isometric view according to the pin array drug delivery device of embodiment.

Figure 24 C are the bottom isometric view according to the pin array drug delivery device of embodiment.

Figure 25 shows the composition of human skin.

Figure 26 shows the physiological period of hair growth.

Figure 27 shows the acquisition of the donor follicular carried out according to embodiment.

Figure 28 shows the preparation of the receptor site carried out according to embodiment.

Figure 29 shows acquired hair skin graft is positioned at receptor site according to embodiment.

Figure 30 shows the placement in occiput scalp donor site according to the plate of the tape punching of embodiment.

Figure 31 is shown to be worn according to embodiment when flap knife is configured to be penetrated into subcutaneous layer of fat to capture hair follicle The flap knife penetration depth of transdermal.

Figure 32 shows being obtained in occiput scalp donor site using the hair of the plate of tape punching according to embodiment.

Figure 33 shows the formation of the visible hair line according to embodiment.

Figure 34 is shown according to plate of the utilization of embodiment with template and tape punching and spring-loaded pixelation device And produce the preparation with the donor site of identical defect of skin at receptor site.

Figure 35 show passed through according to embodiment it is corresponding caused by the skin graft of acquisition is inserted at receptor site Defect of skin in acquisition skin graft transplanting.

Figure 36 is shown according to embodiment using pixel dermatotome instrument and the clinical endpoint of operation.

Figure 37 is the image according to the skin tatooed at the turning and intermediate point for treating cut-away area of embodiment.

Figure 38 is the image according to the postoperative skin cut-away area of embodiment.

Image when Figure 39 is postoperative 11 days according to embodiment, it shows first intention by the edge through measurement Cutout unit.

Image when Figure 40 is postoperative 29 days according to embodiment, it shows first intention by the edge through measurement Cutout unit and continue a phase cut-away area the stage of ripeness.

Image when Figure 41 is postoperative 29 days according to embodiment, it shows first intention by the edge through measurement Cutout unit and continue a phase cut-away area the stage of ripeness.

Image when Figure 42 is postoperative 90 days according to embodiment, it shows first intention by the edge through measurement Cutout unit and continue a phase cut-away area the stage of ripeness.

Embodiment

What embodiment described herein met the aesthstic market of expansion is used for aesthetic surgical operation skin The instrument tightened up and operation.In addition, the embodiment makes it possible to repeat to obtain skin graft from same donor site, simultaneously Eliminate donor site deformity.Embodiment described herein is configured to cut off unnecessary relaxation skin without can be visible Scar formed so that all areas of redundant skin relaxation can cut off by pel array formula dermatotome, and operation can be with Carried out in the region that can not be previously set foot in due to the observability of surgical incision.Pass through embodiment party described herein The technique effect that formula is realized includes not having the smooth of visible scar or long scar and the skin tightened up along anatomical borders.

The embodiment including pixel dermatoplasty apparatus and method being described in detail herein is configured to provide Donor site repeats to obtain the ability of lift height skin graft in the case of forming the visible scar of minimum degree.Performing the operation Period, " pel array formula dermatotome (PAD) " device are used to obtain skin graft from selected donor site.In average of operation periods Between, pixelation skin graft is deposited on flexible, semi-porous adhesiveness film.Acquired skin graft/film is compound Thing is then directly applied to the defect of skin position of acceptor.Donor site through substep excision is to be used as big butterfly by application Bandage effect up to a period of time (for example, one week etc.) adhesiveness piece or bandage (for example,Piece etc.) and close. Intracutaneous defect of skin closure is to promote first intention process as caused by PAD, during first intention, normal epidermis-true Skin structure is rearranged in a manner of anatomical so that scar forms minimum.In addition, following situations also occur after surgery：Adhesion Property film comes off (disengaging) with the cuticula of graft, and the film can be then in the case where not destroying graft from recipient bed Remove.

The many effects realized by pixel skin graft operation should be explained.Because skin graft is pixelation , the gap for the discharge opeing between skin pixels part is thus provided, compared with flaky skin graft, this increasing The strong ratio of " use ".Between (about) period 1 after surgery, skin graft by by the process of neovascularization and Occupy at receptor site, during neovascularization, new blood vessel grows into new skin from the acceptor bed of defect of skin In graft.Diffusate is directed in dressing by semi-porous film.

Flexible film is designed to have elastical retraction characteristic, and the elastical retraction characteristic promotes component skin graft in graft/film Apposition in compound；So as to promote skin to move a phase adjacent healing of skin grafts, so as to by the pixelation of skin graft Outward appearance is transformed into uniform lamellar morphology.In addition, the film is directed at the component skin graft of micro-structural, therefore epidermis is aligned simultaneously with epidermis And corium is aligned with corium, so as to promote to reduce the first intention process of scar formation.

The dermatotome being described in detail herein has many main clinical practices, including the substep skin for dermostenosis Skin resection, the substep hair grafting for alopecia and for dermatoplastic substep skin obtain.Embodiment It is distributed skin excision art and obtains skin graft including the use of adhesiveness film, has been distributed ground however, it is possible to be extracted out in the case where not obtaining The skin graft cut out.The example for cutting out, extracting out and closing can most describe the clinical practice of dermostenosis.Implementation described herein Mode, which is configured so that, to cut out and extracts out, and in order to provide the flap knife array with greater number of flap knife, the reality Applying mode includes cutting the new device of skin surface.

Described is the pel array formula for skin graft operation and skin excision operation and hair transplant operations Medical system, medicine equipment or Medical Devices.In the following description, many specific details are introduced into provide to the reality in text Apply the comprehensive understanding of mode and possible description.However, those skilled in the relevant art are it will be recognized that these embodiments can To be implemented to without one or more specific details in the specific detail or be implemented to that there are other portions Part, system etc..In other examples, well-known structure or operation have been not shown or are not described in detail to avoid Make each side of disclosed embodiment unclear.

Following term is intended to have following general meaning as used herein.However, the skill due to such as this area As art personnel understand or applied, the meaning of any term may all include other meanings, therefore these terms are not limited to Meaning set forth herein.

" first-degree burn " includes the superficial heat injury that the separation of epidermis and corium is wherein not present as used in this article.One Degree burn is intuitively showing as the erythema (rubescent) of skin.

" second-degree burn " includes the separation that epidermis and corium wherein be present and wherein variable thickness as used in this article The relatively deep burn that has also been denatured of corium.Most of second-degree burns are associated with the formation of blister.Deep second degree burn leads to Full thickness third-degree burn often may be transformed into due to aoxidize or infecting.

" third-degree burn " is broken including the full thickness heat with the skin including epidermis and corium as used in this article Bad associated burn.Third-degree burn is also possible to associated with the heat damage of deeper hypodermis (hypodermic layer and muscle layer).

" ablation " is included by being removed to disorganization and the tissue carried out, for example, by swashing as used in this article The thermal ablation for the skin lesion sites that light is carried out.

" autograft " includes the graft obtained from same patient as used in this article.

" the adhesiveness film of tape backing " includes the elastic adhesiveness film for the skin graft that capture is crosscut as used in this article.It is real The adhesiveness film of the tape backing of mode is applied back to outer surface to keep the alignment of skin graft during skin graft is obtained.Obtain skin graft it Afterwards, backing is removed from the adhesiveness film with acquired skin graft.The film of embodiment is being set to be porous with permission Discharge opeing when at receptor site.The also flexible contraction performance of the film of embodiment so that when backing is removed, film makes skin graft Side it is closer with promote sheet graft is restored at receptor site.

" burn wound contraction " includes the receipts of the scar tissue occurred during wound healing process as used in this article Tightly.The process is likely to occur along with the third-degree burn of untreated.

" burn wound contracture " includes the scar tissue band of the range of movement in limitation joint or made as used in this article The scar tissue band of the appearance torsional deformation of patient, i.e. facial burn wound contracture.

" dermatotome " includes " cutting skin " or obtains the device of sheet lift height skin graft as used in this article Tool.The dermatomic example of cydariform includes Padgett types dermatotome and Reese type dermatotomes.Electronic dermatotome is planted for Zimmer types Dermatotome and a kind of powered version Padgett type dermatotomes.

" corium " includes the deep layer of skin as used in this article, and the deep layer of the skin is main structure support and main Including acellular collagen fiber.Fibroblast is the cell of the generation collagen fabric in corium.

" donor site " includes the region of anatomy for obtaining skin graft therefrom as used in this article.

" epidermis " includes the outer layer of skin as used in this article, the outer layer of the skin include epidermal cell living and Nonactive cuticula as biological barrier.

" excision " includes the operation removal of tissue as used in this article.

" defect of skin of excision " includes being drawn by the operation removal (cut off/cut off) of skin (damage) as used in this article The segment thickness defect or more typically full thickness defect risen.

" FTSG " includes " full thickness skin graft " as used in this article, at " the full thickness skin graft " In be obtain skin whole thickness.In addition to apparatus as described in this article, donor site is closed as operative incision 's.Therefore, FTSG is limited in the surface region that can be acquired.

" granulation tissue " is included in the lacking in response to skin in full thickness defect of skin position as used in this article The very vascular tissue for losing and growing.Granulation tissue is the preferable base portion for dermatoplasty receptor site.

" first intention " includes such wound healing process as used in this article, in the wound healing process, just Normal anatomical structure is formed and rearranged with minimum scar tissue.For from form, scar, which is unlikely to be, to be seen Obtain.

" healing by second intention " includes texturizing weaker wound healing process as used in this article, wherein, healing is adjoint What the normal less alignment of anatomical structure and adjoint scar collagen deposition increased and occurred.For from form, scar more has It is probably what is seen.

" alloplast " includes being derived from different people and as interim biological dressing being employed as used in this article To the graft of the receptor site of patient.Most of alloplasts are acquired as dead volume skin.Alloplast it is interim " use " possible concomitant immunity suppresses and part is realized, but if patient is survived, then alloplast is finally by autotransplantation Thing is replaced.

" incision " includes being formed operative incision without removing tissue as used in this article.

" netted lift height skin graft " includes such lift height skin graft as used in this article, should Lift height skin graft be repeatedly cut acquired skin graft by using the apparatus referred to as " into wire stitcher " and The lift height skin graft is set to be expanded in its surface region.Netted lift height skin graft has to be transplanted than sheet Higher " use " ratio of thing, reason are that netted lift height skin graft allows to carry out discharge opeing and more preferable by graft Comply with the profile scrambling of receptor site in ground.However, it can cause the ugly netted of the graft at receptor site really Outward appearance.

" PAD " includes being classified as " the pel array formula for the skin-removed apparatus species of substep as used in this article Dermatotome ".

" PAD external members " includes the operation external member being intended for single use with rear disposable type, the operation external member as used in this article Guide plate including tape punching, flap knife pressing mold, guiding plate framework, the adhesiveness film and revolving knife of tape backing.

" guide plate of tape punching " includes the plate of tape punching as used in this article, and the plate of the tape punching includes whole transplanting Thing obtains region, in the graft obtains region, the hole of guide plate and the flap knife or " slidingtype of pressing mold with handles PAD " is aligned.The plate also will act as protector to prevent from hurting adjacent skin unintentionally.The perforation of guide plate can have not Same geometry, such as, but not limited to：Circular, ellipse, square, rectangle and/or triangle.

" pixelation full thickness skin graft " includes such " full thickness dermatoplasty as used in this article Thing ", it is somebody's turn to do " full thickness skin graft " and has been obtained by apparatus as described herein not have at donor site What is reduced is evident that scar.The outward appearance that the graft will also have the enhancing for being similar to sheet FTSG at receptor site, But the graft will be preferably bonded receptor site and " will be adopted with higher due to the discharge opeing gap between skin graft With " ratio.Compared with sheet FTSG, pixelation FTSG another remarkable advantage is to transplant needs that STSG's is larger originally The ability of surface region.The advantage is due to that can be obtained from multiple donor sites and with the observable scar reduced Ability.

" acquisition of pixelation graft " is including passing through the apparatus being such as described in detail herein from donor as used in this article The skin graft that position obtains.

The part that " pixelation lift height skin graft " includes having been obtained with SRG apparatuses as used in this article is thick Spend skin graft.The skin graft has the advantages of netted skin graft without ugly donor site and acceptor Position.

" receptor site " includes the defect of skin position of application skins based upon bidding graft as used in this article.

" excision " includes cutting off as used in this article.

" scalpel " (scalpel) includes the single cutting tool for cutting skin and soft tissue as used in this article.

" flap knife " (scalpet) includes such term as used in this article, and the term is used to describe to cut skin graft Smaller geometry (for example, circle, ellipse, rectangle, square etc.) scalpel.

" flap knife array " is included by being fixed to substrate (for example, substrate, stamping machine, with handles as used in this article Pressing mold, tip, with tip of rear disposable type etc.) the arrangement that forms of multiple flap knifes or array.

" flap knife pressing mold " includes the flap knife array device element with handles in PAD external members as used in this article, The flap knife array device element with handles cuts skin graft through the guide plate of tape punching.

The histology of " scar " including the disorderly collagen after wound deposits or after wound as used in this article Disorderly collagen histology deposition be evident that morphologic deformity.

As used in this article " sheet full thickness skin graft " include to FTSG as continuous tablet by The denotion of application at body region.FTSG outward appearance is better than STSG outward appearance, therefore, FTSG is mainly used in such as face etc The dermatoplasty being evident that in region.

" sheet lift height skin graft " includes following part thickness skin grafts, the portion as used in this article Point thickness skin grafts are continuous tablets and associated with typical donor site deformity.

" defect of skin " includes the missing of such full thickness skin as used in this article, and the full thickness skin can Also to include the structure of the deeper of subcutaneous layer of fat and such as muscle etc.Defect of skin may because of a variety of causes, i.e. burn Wound, wound, malignant tumour surgery excision and congenital malformation correction and occur.

" skin pixels " include piece of skin as used in this article, it include epidermis and by flap knife cutting part or The corium of full depth；The skin pixels can include cutaneous appendage, such as, with or without the cuff of subcutaneous fat Hair follicle；And " skin pixels " also include skin graft.

" skin graft " includes the pieces of skin of circular (or other geometries) as used in this article, and the pieces of skin includes table The corium of the corium or full thickness of skin and segment thickness, the pieces of skin cut by flap knife, crosscutting by revolving knife and lead to Cross the adhesiveness film capture of tape backing.

" STSG " includes " segment thickness skin graft " as used in this article, in the segment thickness skin graft In, obtain epidermis and a part of corium with graft.

" subcutaneous layer of fat " is included below adjacent skin and mainly by the fat referred to as lipocyte as used in this article The layer of fat cellularity.This layer is used as the main separation layer with environment.

" revolving knife " includes the single cutting tool of horizontal aligument as used in this article, and the single cutting tool can pass through the plate of tape punching Framework groove or be attached to the outer extension member of the dermatome of drum type as being described in detail herein.Revolving knife is to the skin graft that has cut Base portion carry out it is crosscutting.

" wound healing " is included because of any type of wound as used in this article --- and no matter the wound is hot wound, fortune Dynamic one of wound and operation wound or more person --- and caused inevitable biological process.

" xenograft " includes being derived from different plant species and is applied to as interim biological dressing as used in this article The graft of the receptor site of patient.

Herein to pel array formula medical system, medicine equipment or Medical Devices and multiple embodiment party of application method Formula is described in detail.System, apparatus or equipment and method described herein include being used for dermatoplasty and use In skin excision and the minimally heart surgery method of hair transplantation is additionally useful for, wherein, the skin excision is via such as The device that is used in the various surgical operations of plastic surgery operations etc and make pine in the case where not obvious scar is formed The skin-tightening of relaxation.In some embodiments, the device is the apparatus with rear disposable type being intended for single use.This paper embodiment party Formula avoids the scar related to operation and is formed and clinical variation caused by Electromagnetic Heating is carried out to skin and is used as to skin Skin carries out the minimal invasive alternative solution of large-scale plastic operation excision and performs less multiple pixelation excisions to skin.Herein Embodiment can also be used in hair transplantation, and the observability due to operative scar and cause plastic operation may Used in the body region that can not set foot in.In addition, the situation that this method can be formed in the scar for reducing the donor site of patient Under by the way that the skin of the crosscutting cutting of the tissue site from donor to be got to the defect of skin position of acceptor perform skin Transfer operation.

For with age-related cutis laxa (as non-limiting example：Neck and face, arm, oxter, greatly Leg, knee, buttocks, belly, chest line, mastoptosis etc.) many patients for, instead of being formed with its inevitable scar Plastic operation, this paper minimal invasive pel array formula Medical Devices and method perform it is crosscutting to the pixelation of unnecessary skin/ Or excision.Generally, operation described herein is performed under local anaesthesia state in Dental office and had minimum Peri-operation period discomfort, but be not limited thereto.Compared with the prolonged healing stage of plastic operation, it is only necessary to shorter Convalescence, preferably dressing and Support cover thing are spread on predetermined time period (for example, 5 days, 7 days etc.) is reached in area for treatment. The pain minimum or without pain associated with operation will be made.

Relatively small as caused by apparatus described herein (for example, in approximate 0.5mm to 4.0mm scope) Defect of skin passes through using adhesivenessPiece closes.As big butterfly bandagePiece can make to control Treat and be pulled on the maximized direction of aesthetic appearance finishing in region.The resilient coverings of compression are used in dressing to enter one The auxiliary aesthetic appearance finishing of step ground.After initial healing stage is completed, multiple small Linear scars in area for treatment By the observability with reduction compared with the larger plastic operation otch in same area.Other dermostenosis due to The wound healing response of delay and may occur within several moons.Embodiment described herein other it is possible should With including hair transplantation and to alopecia, snoring/sleep apnea, orthopedic/physiotherapy, vaginal contraction, female incontinence, stomach The treatment that enteron aisle sphincter tightens.

Great burn is classified by total body surface of burn and by the depth of heat damage, and is used The classification is heavily dependent in the method for handling these burns.First-degree burn and second-degree burn are outer typically by application Treated with ointment and burn dressing in a manner of No operation.Deeper third-degree burn is related to the full thickness heat damage of skin, So as to form full thickness defect of skin.Debridement and the layering for being usually directed to burn eschar to this severely injured surgical procedure are thick Spend the application of graft.

The full thickness defect of skin the most continually formed by the excision of burn, wound or malignant tumour of skin To be closed using conventional apparatus commercially by skin flaps or dermatoplasty.Both operation methods are required for from donor portion Position is obtained.The use of flap includes the base of a fruit's blood supply and as a rule because of needs directly closure donor because needing Position and be further restricted.

Lift height skin graft operation needs to obtain auto-skin grafting from same patient due to immunologic limitation Thing.Generally, the donor site of fire victim is being selected in non-burn area and thick from the non-burn area fetching portion Spend pieces of skin.Part thickness skin defect is formed inevitably at donor site for this operation.The donor Position defect itself is similar to deep second degree burn.By the reepithelialization of donor site come the typically pain of healing and Some days may be continued.In addition, it is usually formed thinner and lighter obvious donor site deformity more permanent than surrounding skin. For the patient with large surface scorch, a large amount of acquisitions of skin graft are also possible to the availability by non-burn area Limitation.

To make defect of skin close two kinds of routines operation method (skin flaps and dermatoplasty) not only with skin The notable scar of the receptor site of defect forms associated and associated with the donor site of acquisition graft at it.With Conventional operation is compared, and embodiment described herein includes " pixel type skin graft operation " --- also referred to as pixel battle array Column is performed the operation, and the pixel type skin graft operation eliminates donor site deformity and provided from the donor for including sheet The method that any already present donor site of position or the donor site of pixelation reacquires skin graft.From existing Donor site reacquire skin graft this ability will make for donor area skin surface area requirements reduction And provide and carry out extra skin in the patient of the serious burn of the donor dermal of not burning with limited surface area The ability of transplanting.

" the pixel type skin graft operation " of embodiment is used as full thickness dermatoplasty.Such as skin of face transplanting, Many clinical practices of the reparation of hand operation and congenital malformation etc are most preferably held by full thickness dermatoplasty OK.Compared with lift height skin graft, quality, the colour of skin of full thickness skin graft are all similar with overall pattern In the skin adjacent with defect.Therefore, be evident that in region carry out full thickness dermatoplasty in terms of outward appearance it is excellent In lift height dermatoplasty.The dermatoplastic major defect of full thickness under routine operation is by full thickness donor The huge Linear scars that the surgical closure of position defect is formed；This scar limits the dermatoplastic size of full thickness And practicality.

By comparison, the full thickness dermatoplasty of " pixel type skin graft operation " described herein is due to eliminating Linear donor site scar and be less subject to size and practicality limitation.Therefore, generally covered with lift height skin graft Many defects of skin of lid will be changed to treat using the full thickness skin graft of pixelation.

" pixel type skin graft operation " provides to be obtained in the case of the visible scar of donor site formation minimum degree Take the ability of lift height skin graft and full thickness skin graft.During operation, " pel array formula dermatotome (PAD) " device is used to obtain skin graft from selected donor site.During operation is obtained, pixelation dermatoplasty Thing is deposited on adhesiveness film.The adhesiveness film of embodiment includes flexible, semi-porous, adhesiveness film, but embodiment party Formula is not limited thereto.Acquired skin graft/membrane complex is then directly applied to the defect of skin position of acceptor. Donor site through substep excision is to be used as big butterfly bandage effect up to the adhesiveness of week age by application Piece closes.The intracutaneous Round scalp defect of relatively small (for example, 1.5mm) is set to close to promote first intention process, During first intention, normal epidermal-dermal structure is rearranged in a manner of anatomical so that scar forms minimum.Separately Outside, following situations occur within about one week after surgery：Adhesiveness film comes off (disengaging) with the cuticula of graft, and the film can be with Then removed in the case where not destroying graft from recipient bed.Therefore, in the situation for not accommodating scar formation of minimum degree Under, donor site rapidly heals.

It is pixelation due to using the skin graft at acceptor defect of " pixel type skin graft operation ", The gap for the discharge opeing between skin pixels part is thus provided, compared with flaky skin graft, this enhancing The ratio of " use ".Between (about) period 1 after surgery, skin graft will be accounted for by the process of neovascularization At receptor site, during neovascularization, new blood vessel grows into new skin from the acceptor bed of defect of skin and moved In plant.Diffusate (fluid) is directed in dressing by semi-porous film.In addition, flexible film is designed to have elastical retraction spy Property, the elastical retraction characteristic promotes apposition of the component skin pixels in graft/membrane complex and promotes skin graft The a phase adjacent healing of pixel, so as to which the pixel aspect of skin graft is transformed into uniform lamellar morphology.In addition, the film Make the component skin pixel alignment of micro-structural, therefore epidermis is aligned with epidermis and corium is aligned with corium, so as to promote to reduce The first intention process that scar is formed.In addition, pixelation skin graft is easier to be bonded irregular receptor site.

Embodiment described herein also includes " pixel type skin excision operation ", and it is also referred to as " pixel herein Formula is performed the operation ".For with age-related cutis laxa (neck and face, arm, oxter, thigh, knee, buttocks, abdomen Portion, chest line, mastoptosis etc.) many patients for, the substep resection of excess skin can be replaced having inevitable Scar formed plastic operation a big chunk.Generally, pixel type operation will in Dental office, in local anaesthesia state Lower execution.The convalescence after Miles operation includes wearing Support cover thing in the number of days for reaching predetermined quantity (for example, 5,7 etc.) in area for treatment (for example, 5 days, 7 days etc.).Expectedly the relatively small pain or without pain associated with operation.Less (for example, 1.5mm) Round scalp defect will be by using adhesivenessPiece closes.As big butterfly bandagePiece is pulled on the maximized direction (" vector ") of aesthetic appearance finishing for making area for treatment.The elasticity of compression Covering is subsequently applied in dressing further to aid in aesthetic appearance to repair.After initial healing stage is completed, treatment Multiple small Linear scars in region will not be clearly visible.Further, since the wound healing response of delay, then will be Dermostenosis within several months outside amount.Therefore, " pixel type operation " is formed for the huge scar of plastic operation Minimally heart surgery alternative solution.

The pel array formula Medical Devices of embodiment include PAD external members.Fig. 1 shows being arranged on according to embodiment The PAD external members of target site.The PAD external members include guide plate (guide plate), flap knife pressing mold or the bag of flattened tape punching Include the equipment (Fig. 1 to Fig. 3) of flap knife array, the adhesiveness film of tape backing or adhesiveness substrate (Fig. 4) and skin pixels are horizontal Cutting knife (Fig. 5), but be not limited thereto.The flap knife pressing mold of embodiment is handheld device, but is not limited thereto.Guide plate It is optional in alternative embodiment, as described in detail herein.

Fig. 2 is the section according to the flap knife pressing mold of the PAD external members for including flap knife array of embodiment.Flap knife Array includes one or more flap knifes.Fig. 3 is the skin graft according to the PAD external members for including flap knife array of embodiment The partial cross section of knife pressing mold.The partial cross-section shows that the total length of the flap knife of flap knife array is the guiding by tape punching What the thickness of plate and the penetraction depth entered in skin determined, but embodiment is not limited thereto.

Fig. 4 shows adhesiveness film (the adhesiveness base with backing being included in PAD external members according to embodiment Bottom).The basal surface of adhesiveness film is applied to the skin being cut open of target site.

Fig. 5 is shown according to embodiment when the adhesiveness film with PAD external members framework when blade assembly is used together (adhesiveness substrate).The top surface of adhesiveness film is located so that adhesion is lateral lower and is located on the inside of framework, and the adhesiveness Film is then pressed against on the plate of tape punching to capture herein the also referred to as skin pixels being extruded of piece or skin graft.

Reference picture 1, during the operation using PAD external members, the guide plate of tape punching is applied to skin excision/donor portion Position.Flap knife pressing mold is employed through at least one set of perforation of the guide plate of tape punching to cut skin pixels.When the skin of pressing mold When piece knife array includes the total quantity less flap knife of the perforation than guide plate, flap knife pressing mold is applied multiple times to be worn in multigroup Hole.After the continuous application one or more times by flap knife pressing mold, the skin pixels or skin graft that are cut open are captured Onto adhesiveness substrate.Then adhesiveness substrate is caused to capture the skin pixels or skin graft being extruded using adhesiveness substrate.Make For example, the top surface of the adhesiveness substrate of embodiment is oriented so that adhesion is lateral lower and (works as use on the inside of framework During framework), and the adhesiveness substrate is then pressed against the skin pixels or skin being extruded above the plate of tape punching to capture Piece.When film is pulled upwardly, it is crosscutting that the skin pixels that are captured are crosscut knife at its base portion.

Fig. 6 shows the removal of the skin pixels carried out according to embodiment.Adhesiveness substrate is from (leaving) target site Upwards and pull back, and this is lifting or pull the skin pixels or skin graft that are cut open.When adhesiveness substrate by During upper pulling, revolving knife is used for the base portion of the crosscutting skin pixels being cut open.Fig. 7 is to pass through PAD external members according to embodiment The crosscutting side view with the removal for the skin pixels being cut open of blade of progress.By being carried out to the base portion of skin pixels or skin graft It is crosscutting to be obtained to complete pixel.Fig. 8 is mutual using perioperative blade/pixel of PAD external members according to embodiment The isometric view of effect.Fig. 9 is (for simplicity, the blade during the operation of PAD external members is used according to embodiment Be removed) another view, this view show that the acquired skin pixels or skin graft that have been crosscut and before crosscutting Capture but both not crosscutting skin pixels or skin graft.At donor site, pixelation skin excision position is to pass through applicationPiece closes.

Guide plate and flap knife equipment are additionally operable to produce defect of skin at receptor site.Defect of skin is configured to receive The skin pixels for obtaining or capturing at donor site.The guide plate used at receptor site can be with donor site The identical guide plate that uses can be the different guide plates with different perforation model or configuration.

The skin pixels or skin graft deposited in crosscutting period in adhesiveness substrate can then be transferred to defect of skin Position (receptor site), at defect of skin position, skin pixels or skin graft are applied in acceptor as pixelation skin graft Defect of skin position.The flexible contraction performance of adhesiveness substrate is to enable skin pixels or skin graft in skin graft Inside more it is closely spaced.The skin pixels being cut open can be directly applied the defect of skin of receptor site from adhesiveness substrate Place.The skin pixels being cut open are applied to be included the skin pixels being cut open being aligned with defect of skin in receptor site, and The skin pixels being cut open are inserted into the corresponding defect of skin of receptor site.

The pel array formula Medical Devices of embodiment include " pel array formula dermatotome (PAD) ".PAD includes being fixed to The flattened array of relatively small circular flap knife in substrate (for example, cover plate), and the skin being combined with substrate Piece knife is herein referred to as flap knife array, pel array or skin graft knife plate.Figure 10 A are the pel array according to embodiment A part side view, the side view shown fixed to the flap knife in cover plate.Figure 10 B are according to alternative embodiment party The side view of a part for the pel array of formula, the side view are shown fixed to the flap knife in cover plate.According to Figure 10 C The top view of the skin graft knife plate of embodiment.Figure 10 D are the close up view according to a part for the skin graft knife plate of embodiment.Skin graft Knife plate is applied directly to skin surface.One or more flap knifes in flap knife array include sharpened surface, pin and Including one of multiple sophisticated pins or more person.

The embodiment of pel array formula Medical Devices and method is come including the use of model (harvest pattern) is obtained Instead of guide plate.Obtaining model includes the instruction on the skin surface at least one of donor site and receptor site Thing or mark, but be not limited thereto.Mark includes may be directly applied to skin to identify any compound of the region of skin Thing.Model orientation is at donor site and the flap knife array of device is aligned or pressed with the acquisition model at donor site for acquisition It is aligned according to the acquisition model at donor site.Skin pixels are by flap knife array described herein and the quilt at donor site Cut.Receptor site by model orientation is obtained at receptor site by preparing.Mould is obtained used at the receptor site Type can be with donor site used in identical obtain model, or can be with different markup model or structure The different of type obtain model.Defect of skin is produced at receptor site and at receptor site using the skin picture being cut open Element, as described in this article.Alternatively, the guide plate of embodiment uses when application obtains model, but embodiment is simultaneously It is not limited to this.

In order to which using the operating theater instruments set up, the array of embodiment is to combine dermatome of drum type --- such as Padget Type dermatotome or Reese type dermatotomes, but be not limited thereto --- or use as the remodeling of the dermatome of drum type.This The Padget types dermatome of drum type quoted in text is initially researched and developed by Earl doctors Padget in the 1930s, and whole Constantly it is widely used in the dermatoplasty carried out by plastic operation in individual world wide.The dermatomic Reese of Padget types Type remodeling is then developed preferably to calibrate the thickness of acquired skin graft.The dermatome of drum type of embodiment is single It is secondary use (each operation) with rear disposable type, but be not limited thereto.

Generally, Figure 11 A show the example of the roller pixel drum 100 according to embodiment.Figure 11 B show basis The example of the roller pixel drum 100 being assembled on handle of embodiment.More specifically, Figure 11 C are depicted according to embodiment party Formula for the dermatome of drum type that is used together with skin graft knife plate.

Generally, as all pixel type devices described herein, the geometry of pixel drum 100 can have It is variously-shaped without limiting, for example, circular, semicircular, oval, square, flat or rectangle.One In a little embodiments, pixel drum 100 is supported by axle/handle assembly 102 and around the drum rotating part energized by such as electro-motor Part 104 rotates.In some embodiments, pixel drum 100 can be placed on support (not shown) when not in use, wherein, The support is also used as the battery charger of bulging electronic rotation part or the battery of the electrical components of syringe plunger fills Electrical equipment.In some embodiments, can be to the skin surface application vacuum plant (not shown) of pixel drum 100, and can be with Tracking and stability of the outer extension member (not shown) for pixel drum 100 are set.

In some embodiments, pixel drum 100 includes the flap knife array 106 on the surface of pixel drum 100 Produce multiple small (for example, 0.5mm to the 1.5mm) circular incisions for being herein referred to as skin graft.In some embodiments, The boundary geometry of flap knife can be designed to reduce contact pin buffering (" valve ") while skin graft is formed.Instead of circle Shape skin graft, the girth of each skin graft can also be lengthened out into by flap knife --- as non-limiting example --- semicircle The skin graft of shape, ellipse or square.In some embodiments, the length of flap knife 106 can be according to by surgeon's pin The thickness --- i.e. segment thickness or full thickness --- for the skin area selected to dermatoplastic purpose and change.

When pixel drum 100 is applied to skin surface, the blade 108 of inside of pixel drum 100 is arranged on to passing through skin The base portion progress of each skin graft caused by the array of piece knife is crosscutting, wherein, internal blade 108 is connected to center drum axle/handle group Part 102 and/or the outer extension member with being attached to central shaft assembly 102 are connected.In some alternative embodiments, to skin The base portion of otch carry out it is crosscutting in the case of, internal blade 108 is not attached to bulging shaft assembly 102.In some embodiments, as The internal blade 108 of plain drum 100 can manually vibrate or be energized by electro-motor to vibrate.The circle roused according to pixel The density of shape flap knife, can in the region of excessive cutis laxa to the skin of variable proportion (for example, 20%, 30%, 40% etc.) carry out crosscutting.

In some embodiments, additional pixel drum-type getter 112 is provided with pixel drum 100 and is obtained with passing through Tissue from pixel donor through crosscutting/pixelation skin incision/skin graft (pixel type graft) and be aligned with interior Serve as a contrast on the adhesiveness film 110 in the inside of pixel drum 100 to perform dermatoplasty operation.Flap knife array 106 and adhesiveness film Formed with the narrow gap for internal blade 108 between 110.

In embodiments, in the case where the base portion progress of the circular skin graft to being cut open is crosscutting, blade 108 is arranged on The outside of pixel drum 100 and flap knife array 106.In another embodiment, it is outside when the base portion of skin incision is crosscut Blade 108 is connected to bulging shaft assembly 102.In alternative embodiment, when the base portion of skin incision is crosscut, external blade 108 are not attached to bulging shaft assembly 102.The adhesiveness film 110 that the skin section being crosscut is extracted and is aligned is arranged on trouble later Above the defect of skin position of person.Blade 108 (internal or outside) can be that the band being aligned with flap knife array 106 is worn One layer of blade in hole, but be not limited thereto.

The conformal adhesiveness film 110 of embodiment can be being extracted with allowing to work as from pixel drum with alignment for semi-porous The skin section being crosscut film and discharge opeing is carried out when the film is applied as skin graft at acceptor defect of skin.Adhesion The semi-porous eardrum 110 of property can with flexible contraction performance so that be crosscut/pixelation skin graft is transplanted to acceptor together Defect of skin position on, i.e. in the adhesiveness film with pixelation graft after pixel drum 100 is extracted, can make The edge of each skin graft is close together with as piece evenly.Alternatively, the semi-porous eardrum 110 of adhesiveness can Expand to cover the defect of skin position of the larger surface area of acceptor.In some embodiments, in adhesiveness film 110 and drum Can be applied between formula getter 112 has a piece of adhesiveness backing 111.As being described in detail herein, the drum-type battle array of flap knife Row 106, blade 108 and adhesiveness film 110 can be assembled on existing pixel drum 100 together as sleeve.

The inside drum-type getter 112 of the pixel drum 110 of embodiment is with rear disposable type and is interchangeable.Can With by include but is not limited to electronics, EPROM (erasable and programmable readonly memor), machinery, durable device realizes Limitation and/or the use for controlling the part with rear disposable type.Can after the drum rotation number and use roused with the pixel of rear disposable type Electronics the and/or mechanical record and/or limitation for abandoning the access times of the pixel drum of formula can electrically or mechanically be remembered Record, control and/or limitation.

During the fetching portion performed the operation with dermatome of drum type, PAD flap knifes array is directly applied to skin table Face.In order to circumferentially cut skin pixels, dermatome of drum type is positioned on flap knife array so that load to be applied to the skin of lower section On skin surface.By lasting loading, the skin pixels being cut open are extruded through the hole of flap knife array and are captured to drum On adhesiveness film on formula dermatotome.The dermatomic overhanging blade of cutting (being positioned above flap knife array) is crosscutting to be extruded Skin pixels base portion.The compound of film and pixelation skin is then removed from dermatome of drum type, to be used as dermatoplasty Thing is applied directly to acceptor defect of skin portion.

Reference picture 11C, as described in this article, embodiment include being used to plant with the drum-type that skin graft knife plate is used together Dermatotome.More specifically, Figure 12 A show the dermatome of drum type being positioned on skin graft knife plate according to embodiment.Figure 12 B are root According to the alternative view of the dermatome of drum type being positioned on skin graft knife plate of embodiment.Will be in the skin graft in the skin graft being extruded Base portion at be crosscut in the case of, the overhanging blade positioning of cutting of dermatome of drum type is on the top of flap knife array.

Figure 13 A are that dermatome of drum type (such as Padgett types dermatotome) is applied into skin graft knife plate according to embodiment The isometric view of top, wherein, adhesiveness film is applied to the plant before dermatomic drum rolls in cover plate In the drum of dermatotome.Figure 13 B are to be shown according to the side view of a part for the dermatome of drum type of embodiment, the side view Relative to the blade position of skin graft knife plate.Figure 13 C are according to the side view of the part of the dermatome of drum type of embodiment, are somebody's turn to do Side view shows the different blade positions relative to skin graft knife plate.Figure 13 D are the dermatome of drum type according to embodiment Side view, the dermatome of drum type have another blade position relative to skin graft knife plate.Figure 13 E are having according to embodiment The side view of the dermatome of drum type of crosscutting cutter holder, the side view show skin pixels are carried out by cutter holder it is crosscutting.Figure 13 F For the dermatome of drum type according to embodiment and the upward view of skin graft knife plate.Figure 13 G are the dermatome of drum type according to embodiment With the front view of skin graft knife plate.Figure 13 H are according to the dermatome of drum type of embodiment and the rearview of skin graft knife plate.

According to clinical practice, dermatome of drum type can be used for deposition/processing with the adhesiveness film of rear disposable type and cut The relaxation skin removed or acquisition/aligned pixel skin graft.

Embodiment described herein also includes being used to make skin graft with dermatotome such as Padget types dermatotome and Reese types " the pixel type onlay sleeve (POS) " that knife is used together.Figure 14 A are shown according to embodiment with " pixel type height is embedding The dermatomic assembling figure of body sleeve (POS) ".POS include dermatotome and with adhesiveness backing, adhesive and flap knife array The blade being combined.Adhesiveness backing, adhesive and flap knife array and the device are combined into one, but are not limited thereto. Figure 14 B are the dermatomic exploded view with " pixel type onlay sleeve (POS) " according to embodiment.Figure 14 C are shown According to the dermatomic part with " pixel type onlay sleeve (POS) " of embodiment.

The POS of " sleeve " also called herein provides carries out substep excision and right for the relaxation skin to redundancy Defect of skin carries out the dermatoplastic dermatome of drum type onlay with rear disposable type of substep.Onlay sleeve is used as and is intended for single use The part with rear disposable type be used in combination with Padget types dermatotome and Reese type dermatotomes.The POS of embodiment is slip The sleeve of the three rear disposable types of sideslip dynamic formula on to dermatome of drum type.The device includes adhesiveness film and with internal crosscutting The flap knife drum-type array of knife.The revolving knife of embodiment includes the unilateral cutting table of the horizontal inner surface for plunderring flap knife drum-type array Face.

In alternative blade embodiment, the inner surface of the incised layer covering flap knife array of tape punching.With each From cutting surfaces each perforation with it is each individually flap knife be aligned.Horizontal instead of the base portion to crosscutting skin graft plunders fortune Dynamic, the incised layer of tape punching vibrates on the drum-type array of flap knife.Between adhesiveness film and flap knife array formed with for The narrow gap of blade movement.In order to repeatedly be obtained during skin graft operation, it is provided with for extra adhesiveness film Insertion groove.Protective layer above adhesiveness film is peeled off on the spot by elongated extraction convex portion, and the elongated extraction convex portion is in sleeve It is pulled on the opposite side of component from extraction groove.As other pixel type equipment embodiments, adhesiveness film is semi-porous For in the position discharge opeing of acceptor defect of skin.In order that pixelation skin graft becomes more continuous piece, film may be used also With flexible contraction performance to provide skin graft being more closely spaced in skin graft.

Embodiment described herein is including " slidingtype PAD ", " slidingtype PAD " is configured with Padgett types for this Dermatotome or the dermatomic equipment with rear disposable type being intended for single use of Reese types.Figure 15 A are shown according to embodiment just Slidingtype PAD on Padgett type dermatomes of drum type are slided into.Figure 15 B show being arranged on according to embodiment The assembling figure of slidingtype PAD on Padgett type dermatomes of drum type.

The slidingtype PAD (alternatively) of embodiment is used in combination with the guide plate of tape punching.Figure 16 A are shown according to reality That applies mode is arranged on the slip being used together above Padgett types dermatome of drum type and with the template or guide plate of tape punching Formula PAD.The guide plate of tape punching be arranged on above purported skin site and on the basal surface for passing through skirtboard keeping taking To adhesive and be held in place.Padgett types dermatotome leading in the tape punching on skin with slidingtype PAD Rolled above corbel back slab.

Figure 16 B are shown to be obtained according to embodiment with Padgett types dermatome of drum type and mounted slidingtype PAD Skin pixels.In order to carry out skin pixels acquisition, slidingtype PAD is removed, and adhesiveness band is used in Padgett type dermatotomes Drum above, and clip blade is installed on dermatomic overhanging arm, and the blade is subsequently used in crosscutting skin picture The base portion of element.The slidingtype PAD of embodiment is also (alternatively) together with the standard procedures apparatus of such as belt retractor etc Using to protect the adjacent skin of donor site.

The embodiment of pixel type apparatus described herein include as being intended for single use with the apparatus of rear disposable type or " pixel dermatome of drum type (PD2) " of device.PD2 includes being attached to the cylindrical member or rolling/rotation drum of handle, and should Cylindrical member includes flap knife drum-type array.Internal blade is with drum axle/handle assembly interlocking and/or with being attached to the overhanging of the axis of centres Part interlocks.As PAD described herein and POS, small more pictures to skin are directly performed in the region of cutis laxa Elementization is cut off, so as to strengthen dermostenosis in the case of the formation of the visual scar of minimum.

Figure 17 A show " the pixel drum-type plant of the target site for being applied to skin surface according to embodiment The example of dermatotome ".Figure 17 B show " the pixel drum of the target site for being applied to skin surface according to embodiment The alternative view of a part for formula dermatotome ".

PD2 devices will entirely roll/rotate drum and apply to skin surface, at skin surface, by the way that " flap knife rouses Formula array " generates multiple small (for example, 1.5mm) circular incisions in target site.In the base portion of each skin graft is then used Portion's blade is crosscutting, and the internal blade and center drum axle/handle assembly interlocking and/or the outer extension member with being attached to the axis of centres are mutual Lock.According to the density of the circular flap knife in drum, the skin of percent of total variable can be cut off.PD2 makes it possible to excessive Part (for example, 20%, 30%, 40% etc.) table of skin is cut off in the case of not forming visual scar in the region of cutis laxa Face area, but embodiment is not limited thereto.

Another alternative embodiment of pixel type apparatus presented herein is " pixel drum-type getter (PDH) ".With Pixel dermatome of drum type is similar, and the pixelation cutout unit of skin is obtained and is registered to adhesiveness film by the inside drum of addition On, the adhesiveness film is subsequently disposed on the acceptor defect of skin position of patient.Conformal adhesiveness film for semi-porous with Allow when the film of the skin section being crosscut with alignment is extracted from drum and applied as skin graft Discharge opeing is carried out at acceptor defect of skin.The elastical retraction characteristic of film allow pixelation skin section more in close proximity to, so as to by Pixelation skin graft is partially converted into sheet graft at body region.

Pel array formula medical system, medicine equipment or Medical Devices described herein and method cause or realized thin Born of the same parents and/or extracellular reaction, the cell and/or extracellular reaction are obligate for the clinical effectiveness realized.Just For pixel dermatotome, due to the pixelation excision carried out to skin, i.e. due to the formation of skin graft, skin surface area occurs Physics reduce.Further, since the wound healing response of delay, result in then tightening up for skin.As being described in detail herein , each pixelation cutout unit starts the obligate wound healing order in multiple stages.

The first stage of the order is the inflammation sexual stage, and in the inflammation sexual stage, the flailing action of mast cell is by group Amine is knitted to be discharged into " wound ".The release of histamine can cause the expansion of capillary bed and increase blood vessel enter it is extracellular Permeability in gap.This wound healing response at initial stage occurs in first day and intuitively will shown as on skin surface Erythema.

Start second stage (stage that fibr tissue is formed) in three to four days of " injury ".During at this stage, deposit In the migration and schizogamy of fibrocyte.The fibr tissue of wound, which is formed, includes the deposition of new collagen and the flesh of wound into fibre Cellularity is tieed up to shrink.

From histology, the deposition of new collagen can be identified as the consolidation of corium and be thickened by microscope.To the greatest extent It is static process to manage this, but the tensile strength of wound significantly increases.Other of fibr tissue formation are characterized in causing wound The dynamic physical processes that multidimensional is shunk.This component characterization that fibr tissue is formed is due to the competent cell of myofibroblast Caused by shrinking.From morphology, the myofibroblast of wound shrinks and will be visualized as the two of skin surface Dimension is tightened up.Generally, the effect that fibr tissue is formed is that corium is shunk and the static state by the framework tightened up of new collagen is propped up Support the deposition of support.Clinical effectiveness is shown as within the several months with the dermostenosis of the smooth delay of texture.Clinical endpoint The usually more aobvious young skin crust of area for treatment.

The phase III of the wound healing response of delay and final stage are the stage of ripeness.In this stage, due to (corium ) the interconnecting for enhancing of collagen fiber matrix and cause the enhancing and remodeling of area for treatment.The final stage is in " injury " Six months afterwards are to beginning in 12 months and may extend up at least 1 year to 2 years.The small pixelation excision of skin Portion is not being formed generally in the case of the obvious scar for carrying out occurring in the case of larger surgery excision to skin at this Normal dermis is kept during the wound healing process of delay.Finally there are the epidermis discharged from epidermal growth hormone Related stimulation and recovery.Can be with scar collagen deposition and in tissue (such as the flesh of the existing collagen stroma with minimum Meat or fat) in cause the wound healing response of delay.

Except for aesthetic purposes and in addition to making dermostenosis, pel array formula medical system described herein, medical treatment Apparatus or Medical Devices and method can have the related application of extra medical treatment.In some embodiments, pel array Formula equipment can in the case of the surgery excision without the help of standard crosscutting any soft tissue structure variable part.More specifically Ground, the reduction of the actinicity damaged area via pel array formula equipment of skin reduce the incidence for making cutaneum carcinoma.Just sleep Dormancy apnea and snoring treatment for, via pel array formula equipment pixelation mucous membrane reduce (soft palate, tongue base portion And lateral pharynx wall) will reduce the great incidence of disease associated with the surgical procedure of more standard.With regard to point of posterior fornix For giving birth to hurt, it will cut off via pixelation skin and the vaginal mucosa excision of pel array formula equipment without the help of A＆P In the case of remold normal antenatal geometry and function.Related female stress urinary incontinence can also enter in a similar way Row correction.

Under the pel array formula dermatotome (PAD) of the also referred herein as flap knife device assembly of embodiment includes State system or external member：The system or external member include the control device of also referred to as punching press impact handpiece and are also referred to as point The skin graft knife system of end device.Removably being attached to the skin graft knife system of control device includes being positioned at flap knife dress Put interior flap knife array.The removable skin graft knife system of embodiment is with rear disposable type and is therefore configured in list Used during individual operation, but the embodiment not limited to this.

The PAD includes following apparatus：The device includes housing, and the housing is configured to include skin graft knife system.The skin Piece knife system includes substrate and flap knife array, and the flap knife array includes setting on the substrate with a configuration Multiple flap knifes, the substrate and the multiple flap knife are configured to deploy and be retracted in housing from housing, and described Multiple flap knifes are configured to produce multiple skin pixels being cut open in target site upon deployment.The near-end end of control device Cage structure is into being hand-held.Housing is configured to removably be attached to the female part of the part as control device. The control device includes proximal end and distal end, wherein, proximal end includes actuator mechanism, and distal end includes Female part.The control device is constructed to rear disposable type, but alternatively, and the control device is constructed to cleaned , it is at least one of sterilized and sterilized.

Flap knife array configuration is unfolded into the startup in response to actuator mechanism.The skin graft knife system of embodiment is matched somebody with somebody It is set to so that flap knife array response deploys and be recovered to flap knife dress in the startup of actuator mechanism from skin graft knife system In putting.The skin graft knife system of alternative embodiment be arranged so that flap knife array response in the startup of actuator mechanism and from Skin graft knife system deploys and is recovered in response to the release of actuator mechanism in skin graft knife system.

Figure 18 shows the side isometric view of the PAD components according to embodiment.The PAD components of the embodiment include quilt The control device of hand-held is configured to, the control device has actuator or trigger, and the skin graft knife system includes skin Piece knife array.The control device is reusable, but alternative embodiment includes the control device with rear disposable type. The flap knife array of embodiment be configured to define or produce as be described in detail herein otch array (for example, 1.5mm, 2mm, 3mm etc.).The skin graft knife system of embodiment includes spring-loaded flap knife array, and it is configured to as detailed herein Cut out skin as description, but the embodiment not limited to this.

Figure 19 A show the top perspective view of the skin graft knife system being used together with PAD components according to embodiment.Figure 19B shows the face upwarding stereogram of the skin graft knife system being used together with PAD components according to embodiment.Skin graft knife system bag Housing is included, the housing, which is configured to house, is attached to plunger or the substrate including plunger.The housing is configured so that the near of plunger End end is stretched out through the top surface of housing.The housing is configured to removably be attached to control device, and post The length configuration of plug stretches out certain distance into through top surface, is controlled with being contacted when skin graft knife system is attached to control device Device and actuator.

The basal structure of skin graft knife system forms many flap knifes of flap knife array into holding.Flap knife array is according to suitable In the flap knife device assembly that uses of operation and flap knife including predetermined quantity.Skin graft knife system includes at least one coiling machine Structure, at least one spring mechanism are constructed to respond to the activation of flap knife array apparatus and provide downward power, impulsive force Or stamping press, and the power helps to produce otch (the skin excision position of pixelation) by flap knife array.Alternatively, Spring mechanism can be configured to provide upward power or withdrawal force, to aid in the retraction of flap knife array.

One of control device and skin graft knife system of embodiment or more person include encryption system (for example, EPROM Deng).The encryption system is configured to prevent skin graft knife system and/or the illegal of control device from using and copying, but not limited to this.

During operation, flap knife device assembly is once applied to target area, or alternatively, is continuously applied It is added in the specified targeted treatment area of cutis laxa.Then as being described in detail herein, pixelation in area for treatment Skin excision position is closed by means of the application of Flexan pieces, and the orientation closure edge of the cutout unit of these pixelations provides The direction of the maximum aesthetics correction of therapentic part is carried out.

The PAD devices of alternative embodiment include being used for vacuum component or the system for removing the skin pixels cut out. Figure 20 shows the side view of the punching press percussion mechanism including vacuum component according to embodiment.The PAD of the example includes true Empty set system or vacuum component, the vacuum system or part are located in control device to be pumped out with the skin pixels cut out, but unlimited In this.The removable mode of the vacuum component is attached to PAD devices, and its use is optional.The vacuum component is attached to One of housing, skin graft knife system, flap knife array and control device or more person and be configured to the one or it is described more Low-pressure area is produced in more persons or adjacent to the one or more persons.The low-pressure area is configured to the skin pixels of incision Extract out.

The PAD devices of another alternative embodiment include being used for radio frequency (RF) component or the radio frequency system for generating skin pixels System.The RF parts are attached to one of housing, skin graft knife system, flap knife array and control device or more person and are configured to Coupling energy is provided in the one or more persons or near the one or more persons.The RF components are with can The mode of removal is attached to PAD equipment, and its use is optional.The energy provided by RF parts include heat energy, vibrational energy, One of energy and acoustic energy or more person are rotated, is named a few here.

The PAD devices of another alternative embodiment include vacuum component or vacuum system and RF parts or RF systems.Should The PAD of embodiment include in the handpiece to the vacuum system or vacuum that pump out the skin pixels cut out Part.The vacuum component is removably attached to PAD devices, and its use is optional.Vacuum component is attached to shell One of body, skin graft knife system, flap knife array and control device or more person and be configured to the one or it is described more Low-pressure area is produced in more persons or adjacent to the one or more persons.The low-pressure area is configured to take out the skin pixels of incision Go out.In addition, PAD devices include RF parts, the RF parts are attached to housing, skin graft knife system, flap knife array and control device One of or more person and be configured in the one or more person or the neighbouring one or more persons carry For coupling energy.The RF parts are removably attached to PAD equipment, and its use is optional.By the RF parts The energy of offer includes heat energy, vibrational energy, rotates one of energy and acoustic energy or more person, names a few here.

As a particular example, the PAD of embodiment includes Electrosurgical generator, and it is configured to more effectively cut out Donor dermal or skin graft so that minimum is damaged to the heat transfer of adjacent skin.Therefore, for example, RF generators are due to relatively short Work period and operated with relatively high-power level.RF generators are configured to dynamic impact device part, circulating flushing One of device, vibrating impactor and ultrasonic transducer or more person is hit to be supplied, wherein, the configuration of dynamic impact device part Into the extra compression stress provided for cutting.

As described in this article, the PAD with RF of this example also includes vacuum component.The vacuum of the embodiment Part is configured to applying vacuum, and the vacuum pulls up skin towards flap knife (for example, chamber etc.) into flap knife, with point What RF that is stable and promoting skin was mediated in step excision area cuts out, but not limited to this.One of RF generators and vacuum or More persons are connected into be controlled by the processor of runs software application.In addition, the PAD of the embodiment can with herein in detail The guide plate of description is used together, but not limited to this.

In addition to being cut out in the substep of donor site, substep dermatoplasty includes being used for the skin graft for migrating to receptor site Acquisition and deposition (for example, depositing on adhesiveness film etc.).As substep skin excision, using negative on flap knife array The RF of load driving, which comes cut edge, to be helped to cut out donor skin graft.The base portion of the flap knife cut out then as being described in detail herein As be crosscut and obtain.

The timing of vacuum aided part is processor controlled, to provide regulation order by the RF work periods.Pass through Software controls, and different variables can provide the RF cuttings being combined and the optimal sequence of vacuum aided.Without limitation, these The initial vacuum phase being included in before the RF work periods.After the RF work periods, the time during the order of embodiment Section includes cutting out the suction of skin graft.

PAD other possible control sequences include but is not limited to working cycles while RF and vacuum aided.It is alternative Ground, the control sequence of embodiment are included in the order and/or in the change of RF power or using different RF frequencies The pulse and circulation of RF work periods in the case of generator.

Another alternative control sequence includes the RF specified the circulations in the depth of substep cut-out portion occur.Have The lower-wattage longer duration RF work periods of the shaft insulation of shaft insulation activity cutting tip can be in deeper dermis/subcutaneous group Knit and heat conduction damage is produced in interface.Deeper fire damage will cause the wound healing sequence of delay, and it by Secondary cases makes skin Tighten up without burned skin surfaces.

Controlled by software, different variables can provide the RF cuttings of the combination with vacuum aided and dynamic power machine is cut The optimal sequence cut.Example includes but is not limited to the auxiliary dynamic power machine cutting of vacuum, with dynamic power machine cutting and vacuum The combination of the RF cuttings of auxiliary, the RF cuttings with vacuum aided and the RF cuttings with vacuum aided.Integration software controls The example of work period include but is not limited to precut vacuum skin stationary phase, there is the RF cutters of vacuum skin stationary phase Make cycle, the RF cutting work periods with vacuum skin stationary phase and dynamic power machine cutting phase, with vacuum skin stationary phase Dynamic power machine cutting, the heat conduction heating for deeper corium and/or hypodermis layer, to cause the wound for dermostenosis The rear cutting RF work periods of healing reaction, and extract the phase out for the rear cutting vacuum of dermostenosis.

Another embodiment of pel array formula Medical Devices described herein includes following apparatus：The device includes making For the flap knife and blade of the flattened array of the oscillatory type of the alternative solution of drum/cylindrical member described herein, this shakes Swing the flap knife of the flattened array of formula and blade is electrically energized or manually sets (non-powered formula) and be used to make skin Skin is tightened up.Figure 21 A show the flattened flap knife array of oscillatory type and the top view of blade apparatus according to embodiment.Figure 21B shows the flattened flap knife array of oscillatory type and the upward view of blade apparatus according to embodiment.Blade 108 can be with It is one layer of blade of the tape punching being aligned with flap knife array 106.Instrument handle 102 is separated and adhered to blade handle 103 Property film 110 can be peeled off from adhesiveness backing 111.Figure 21 C be according to embodiment when flap knife array 106, blade 108, The close up view of flattened array when adhesiveness film 110 and adhesiveness backing 111 are assembled together.When assembled, skin The flattened array of piece knife can be measured to provide uniform acquisition or uniform excision.In some embodiments, skin graft The flattened array of knife can also include being used for the infeed mean 115 that adhesiveness obtains film 110 and adhesiveness backing 111.Figure 21 D For the close up view of the flattened array of the flap knife with infeed mean 115 according to embodiment.

In another dermatoplastic embodiment, pixel type graft is set to dead volume dermal matrix via radiation (not Show) on.It is that identical patient produces in immunology with pixel donor when pixel type graft is cultured on dermal matrix The graft of full thickness skin is given birth to.In embodiments, dead volume dermal matrix can also with terms of size with it is acquired Skin pixels formula graft it is similar mode it is by column crosscutting to provide pixelation graft into dead volume corium framework Histology alignment.Figure 22 shows the dead volume dermal matrix according to embodiment, and the dead volume dermal matrix is with terms of size It is by column crosscutting with the similar mode of acquired skin pixels formula graft.In some embodiments, donor site Acquisition percentage can be organized in partially by normal dermal acceptor defect of skin position inducing action --- i.e., Promote normal (more smooth) the surface topology effect of skin graft --- to determine.Pass through adhesiveness film or dermal matrix Embodiment, pixel drum-type getter include obtain for transplant larger surface region and make the donor site of patient Obvious scar form the ability that significantly reduces or eliminate.

In addition to pel array formula Medical Devices described herein, embodiment includes drug delivery device.It is just big absolutely For part, the non-bowel delivering of medicine is still to be realized by using syringe or pin injection.In order to avoid pin and injection The negative characteristics of device system, it have developed and medicine local absorption is percutaneously carried out by inaccessible patch.However, these drug delivery systems All there is the shortcomings that great.The mankind are not reduced to the detest that pin is injected during nearly twoth century that pin uses.Subcutaneous medicament The variable systemic absorption of injection or neuromuscular drug injection reduces efficacy of drugs and may increase the adverse reaction of patient Incidence.According to the load fat fluid of medicine or aqueous fluid is carried, the inaccessible patch of topical application can by permeate through epidermis barrier Become the puzzlement absorbed.For needing to carry out the patient of local anaesthesia in the large surface regional extent of skin, syringe/pin Injection or local anaesthesia are not preferable.Syringe/pin " field " injection be typically pain and may instill and may draw Play the excessive local anesthetic of systemic toxicity.Local anaesthesia can hardly be provided for the anesthesia water needed for skin related surgical It is flat.

Figure 23 is the drum-type array drug delivery device 200 according to embodiment.The drug delivery device 200 is successfully Solve limitation and the shortcoming of other drugs delivery system.The device includes drum/cylindrical member 202, the drum/cylindrical member 202 are supported by axle/handle assembly 204 and are rotated around drum rotary part 206.The handle assembly 204 of embodiment also includes treating The reservoir 208 and syringe plunger 210 for the medicine being delivered.The surface of drum 202 is by the pin 212 with consistent length Array covered, this patient provides uniform intracutaneous (or subcutaneous) injection depth and is injected into more controlled Medication amount in the skin of patient.During operation, medicine is released reservoir 208 with via connecting tube by syringe plunger 210 216 are injected into the sealing injection room 214 of the inner side of drum 202.When straight in the skin that the array of pin 212 is pushed to patient When untill skin is encountered on the surface of drum 202, the medicine is finally delivered in the skin of patient with consistent depth.It is non- The skin area of anesthesia is avoided and forms more consistent skin analgesia model.The rolling drum of drug delivery device 200 The application of shape part also quickly instillation local anesthetic and patient's is uncomfortable less.

Figure 24 A are the side view according to the pin array drug delivery device 300 of embodiment.Figure 24 B are according to implementation The top isometric view of the pin array drug delivery device 300 of mode.Figure 24 C are the pin array medicine according to embodiment The bottom isometric view of thing delivery apparatus 300.The drug delivery device 300 includes being positioned at available on part flow arrangement 310 In the plane array of the fine needle 312 with consistent length of medicine delivery.In the illustrative embodiments, wherein accommodating The syringe 302 for having the medicine for injection can be planted in the handled adapter 306 with rear disposable type, and can Ensure syringe 302 and 306 connection firmly with each other of adapter with rear disposable type to use seal 308.Work as syringe When plunger 304 is promoted, the medicine that is contained in syringe 302 is delivered to adapter with rear disposable type from syringe 302 In 306.The medicine leads to when the array of pin 312 is pushed in the skin of patient untill part flow arrangement 310 encounters skin The flattened array for crossing fine needle 312 is further delivered in the skin of patient with consistent depth.

The purposes of drug delivery device 200 can have with needing the medicament number of percutaneous injection or absorption facing as many Bed application.As non-limiting example, a small number of potentially applications are the injection of local anesthetic, such as botulin toxin (ripple Lentor) etc the injection of neuromodulator, the injection of insulin and displacement estrogen and corticosteroid injection.

In some embodiments, the syringe plunger 210 of drug delivery device 200 can be dynamical type, as non- Limitative examples, energized by electro-motor.In some embodiments, it is attached to the fluid pump of IV (venous transfusion) bags and pipe (not shown) can be connected to injection room 214 and/or reservoir 208 for continuous injection.In some embodiments, medicine The volume of syringe plunger 210 in thing delivery apparatus 200 is calibrated and is programmable.

The pixel obtained by PAD (pel array dermatotome) device being described in detail herein is dermatoplastic another Using being alopecia.Alopecia is a kind of common aesthstic disease, and it is most common in middle-aged male crowd, but is also seen In the women population of aging baby boom.Most common alopecia form is that the male pattern alopecia in preceding cranial cavity wall area occurs (MPB).Male pattern alopecia is by the sex of the X chromosome transmission from mother.For male, the phenotype is expressed only Need a gene.Because the gene is recessive, therefore female alopecia needs two chain bases of X from both M ＆ Fs The transmission of cause.Phenotype genepenetrance may be different and most commonly in age of onset and forehead/part/occiput between patient The aspect of the amount of alopecia shows.Changeability of the patient in terms of MPB Phenotypic Expressions is due to the variable of this sex Genotype shifts.The generation of genotype based on MPB, to hair transplantation to need be huge.In most of limited population See the related cause of disease of other nongenetics.These non-hereditary cause of diseases include wound, mycotic infection, lupus erythematosus, radiation and Chemotherapy.

A variety for the treatment of options for alopecia have been proposed to the public, have included the topical application medicine of FDA approvals, such as Minoxidil (Minoxidil) and Finasteride (Finasteride), because these media need dormant hair follicle conversion To the regenerative growth phase, so the medicine has the effect of limit.Other are remedied including wig and hair-weaving.The operation of standard is still The hair grafting of operation, including by hair skin graft, bar and skin flaps from crinite scalp to no hair Scalp.For the most part, conventional hair grafting include will multiple single hair micrographs from crinite head What skin was transferred to same patient does not have crinite scalp.Alternatively, obtain first and be used as the donor skin graft of hair band and right Micrograph is secondly divided into afterwards to be transferred to acceptor scalp.Anyway, the operation of the multi-step is tediously long and expensive, Including some operating times for general patient.

Conventional hair transplantation market is pind down by the long-time hair transplant operations carried out in some stages.Typically Hair transplant operations, which are related to, is transplanted to hair skin graft on the preceding cranial cavity wall of alopecia from the donor site in occipital scalp Receptor site.For most of operations, each hair skin graft is individually transplanted to acceptor scalp.If it may need to carry out During the operation of dry hour, hundreds of skin grafts can be transplanted.Due to the factor that the limited new vessels at receptor site is formed, Postoperative " use " or survival of the hair skin graft of transplanting are variable.The bleeding caused by motion and mechanical damage are to reduce New vessels is formed and the key factor of " use " hair grafts.Embodiment described herein includes being configured to one The surgical operating instrument of secondary some hair grafts of transplanting, some hair grafts are whole at the receptor site on scalp Body is fixed and alignd.The operation of PAD described herein using embodiment reduce trifling needed for conventional instrument and Time.

Figure 25 shows the composition of application on human skin.Skin includes two horizontal slices, and described two horizontal slices are referred to as table Skin and corium are simultaneously used as the biological barrier to external environment condition.Epidermis is clad and the survival layer comprising epidermal cell, described The vigor layer of epidermal cell migrates the simultaneously non-viable layer of " maturation " into referred to as cuticula upwards.Cuticula is used as primary biological Lipid-keratin compound of barrier, and the layer continuously comes off and rebuild during referred to as furfur.Corium is following Layer, it is the primary structure supporting of skin and mainly extracellular and be made up of collagenous fibres.

In addition to the epidermis and corium of the horizontal slice, skin also includes vertically disposed element or cell annex, The vertically disposed element or cell annex include pilosebaceous unit, and the pilosebaceous unit includes hair follicle and skin Adipose gland body.Pilo-sebaceous unit each includes grease body of gland and hair follicle.Sebum body of gland is most surface and arranges sebum (oil) It is put into the limb of hair follicle.The base portion of hair follicle is referred to as hair root, and the base portion of hair root has the deep reproduction composition of referred to as papilla Part.Hair follicle generally arranges in a manner of relative to skin surface bevel.The row in parallel with each other of hair follicle in a given area Row.Although pilosebaceous unit is common in whole skin, the density of these units and work in scalp region Property is the Key determining factors of the overall appearance on hair.

In addition to pilosebaceous unit, sweat gland also vertically passes through skin.They, which are provided, contributes to the water base of temperature adjustment Exudate.The reason for apocrine secretion sweat gland in armpit and groin shows more pungent sweat, and this is body odor.For body Remainder for, the sweat that less stimulates of secretion sweat gland discharge is for body heat regulation.

Hair follicle undergoes the different physiological periods of hair growth.Figure 26 shows the physiological period of hair growth.Incline in heredity To people in testosterone presence will in preceding cranial cavity wall produce variable pitch alopecia.Substantially, hair follicle is stopped by entering Phase is changed into resting state without being back to the stage in growth period.Male pattern alopecia occurs that life can not be back to from stand-down in hair When long-term.

The PAD of embodiment is configured to the overall acquisition of crinite skin graft so that moves the entirety of crinite skin graft Plant and do not have in crinite scalp, this shortens the general surgical procedures of hair grafting.Generally, the device of embodiment, be System and/or method be used for single operating procedure or during obtain substantial amounts of small crinite skin graft and make its alignment, And same instrument is used for not having the multiple pixelation of crinite scalp to cut off to prepare receptor site by performing.Multiple hairs Grafts thing is integrally shifted and migrates to the receptor site of preparation.Therefore, it is hundreds of by using simple operation Crinite skin graft can be transferred to receptor site from donor site.Therefore, by using embodiment described herein Hair grafting provide it is a kind of Comparatively speaking have with tediously long and multi-step conventional process easily, it is simple and significantly reduce The solution of the single surgical operation of time.

Contribute to improve conventional standard Follicular Unit extraction using the dermatomic hair transplantation of the pixel of embodiment (FUT) air transplant method.Generally, according to the operation of embodiment, hair follicle to be acquired is from the occipital of donor (Occipital) scalp obtains.So, the hair of donor site is partly wiped off, and the tape punching of embodiment Plate positions on scalp and towards the direction for providing maximum acquisition.Figure 27 shows obtaining according to the donor follicular of embodiment Take.Flap knife in flap knife array is configured to the subcutaneous fat penetrated down to then to capture hair follicle.Once hair skin graft quilt Cut, then carry out crosscutting to the base portion of hair skin graft by using crosscutting blade so that hair skin graft is obtained in adhesiveness substrate On, such as describe in detail herein.By being protected before crosscutting to base portion progress using adhesiveness film at donor site Hold the original alignment of hair skin graft relative to each other.The matrix of the alignment of hair skin graft on adhesiveness film then will be whole The receptor site migrated on the preceding cranial cavity wall of acceptor body.

Figure 28 shows the preparation of the receptor site according to embodiment.By excision and in occiput scalp donor site Acquired no hair skin skin graft of identical model in terms of landform prepares receptor site.Receptor site prepares to use In：Largely hair skin is transplanted by using with the instrument identical instrument according to used in the embodiment at the donor site Piece, and therefore produce scalp defects in receptor site.Scalp defects caused by the receptor site have with adhesiveness film Acquired skin graft identical geometry.

The adhesiveness film of hair skin graft acquired in being loaded with applies the scalp defects of the same model at receptor site Top.Each crinite skin graft is inserted in a manner of by row in the acceptor defect of its mirror image.Figure 29 is shown according to reality Apply mode acquired hair skin graft is placed at receptor site.Skin graft is kept to be aligned with skin graft, so that the hair from transplanting The hair of skin graft growth seems the same in donor site naturally as far as possible.Also will carry out between nature scalp and the hair of transplanting More consistent alignment.

More specifically, the hair of donor site is partly shaved off, to prepare to position or be placed on head by the plate of tape punching Pi Shang.The plate of tape punching is located at occiput scalp donor site to provide maximum acquisition.Figure 30 is shown according to embodiment Placement of the plate of tape punching on occiput scalp donor site.A large amount of acquisitions of skin graft can be by using including with skin graft Knife is realized with the spring-loaded pixelation device of the sophisticated impact punching type handpiece of rear disposable type.One embodiment structure Cause to obtain single skin graft using ready-made FUE extraction elements or biopsy stamping machine；The tape punching provided Hole in plate is sized to be suitable to adapt to prior art.

It is configured to penetrate downwards with the flap knife of rear disposable tips to then capturing hair follicle including flap knife array Subcutaneous fat.Figure 31 is shown to be worn according to embodiment when flap knife is configured to be penetrated into subcutaneous layer of fat to capture hair follicle Cross the flap knife penetration depth of skin.Once hair skin graft is cut open, by using crosscutting blade that the base portion of hair is crosscutting and incite somebody to action It is obtained on adhesiveness film, but not limited to this.Figure 32 is shown to be made according to embodiment in occiput scalp donor site Obtained with the hair of the plate of tape punching.The original of hair skin graft relative to each other is kept by applying the adhesiveness film of embodiment Begin to be aligned.Apply adhesiveness film, but embodiment not limited to this before the base portion that will cut off pixel is crosscutting.On adhesiveness film Hair skin graft alignment matrix then the receptor site before integrally being migrated on cranial cavity wall.

Other single hair skin graft can be obtained by the plate of tape punching, for for example producing visible hair line.Figure 33 show the generation of the visible hair line according to embodiment.Manually FUT technologies determine and researched and developed visible hair line. It can be seen that a large amount of transplanting of hair line and calvarium can be carried out simultaneously or as the single stage.If it can be seen that hair line and a large amount of shiftings Plant is carried out simultaneously, then receptor site is developed since visible hair line.

The transplanting of the hair skin graft of acquisition includes preparing receptor site by following manner：Excision in occiput scalp with supplying No hair skin skin graft of identical model in terms of landform acquired in body region prepares receptor site.Figure 34 is shown Produced according to plate of the utilization of embodiment with template and tape punching and spring-loaded pixelation device with receptor site The preparation of the donor site of identical defect of skin.The receptor site of embodiment uses identical with what is used at donor site Tape punching plate and spring-loaded pixelation device prepare a large amount of transplanting of hair skin graft.Scalp is formed in receptor site Defect.These scalp defects have the skin graft identical geometry on adhesiveness film with acquisition.

By carry the adhesiveness film that obtains hair skin graft be applied to scalp defects at receptor site same template it is upper. Each skin skin graft for having hair or having hair follicle is inserted in its mirror image acceptor defect line by line.Figure 35 is shown according to embodiment The transplanting by the acquisition skin graft in corresponding defect of skin caused by the skin graft of acquisition is inserted at receptor site.By In keeping skin graft to be aligned with skin graft, thus from the hair of the hair skin graft of transplanting growth as it in donor site it is natural. Also alignment more consistent between natural scalp and the hair of transplanting will be produced.

Clinical endpoint is different from patient to patient, but predict the hair skin graft of greater percentage will be new due to improvement Vascularization and " use ".Figure 36 is shown according to embodiment using pixel dermatotome instrument and the clinical endpoint of operation.More The combination of " use " well, shorter operating time and more natural result causes the pixel skin-grafting of embodiment to arrive instrument and hand Art can overcome the defect in conventional air transplant method.

The pixelation dermatoplasty for defect of skin and the pixelation skin for cutis laxa is described in detail herein The embodiment of skin excision.These embodiments remove the skin pixels area in the relaxation skin region for needing dermostenosis.By Defect of skin caused by the operation (for example, in the range of about 1.5mm-3mm diameters) be small enough to first intention without Visible scar is formed；The wound closure of multiple defects of skin is directionally carried out to produce desired outline effect.Pixel is cut off The living animal experiment of art has achieved good effect.

The pixel type operation of embodiment will perform in Dental office, under local anaesthesia state, but not limited to this.Outside Section doctor quickly cuts off skin pixels array (for example, circle, ellipse, square etc.) using the instrument of embodiment.With The associated pain of operation is relatively small.Caused intracutaneous defect is closed by adhesiveness Flexan (3M) pieces during operation Close, but embodiment not limited to this.As big butterfly bandage, Flexan pieces can be such that the aesthetic appearance of area for treatment repairs most It is pulled on the direction (" vector ") changed greatly.The resilient coverings of compression are used in dressing further to aid in outside aesthetics Shape is repaired.During restoration, patient by Support cover thing wear in area for treatment up to a period of time (for example, 5 days etc.).Initial Healing after, multiple small Linear scars in area for treatment will not be clearly visible.Further, since the wound healing of delay Reaction is closed, then by the dermostenosis within several months outside amount.Therefore, " pixel type operation " is the micro- of dermostenosis Invasive operation alternative solution, it avoids the formation of the huge scarring areas of traditional Aesthetic plastic operation.

Pixel type operation causes cell and/or extracellular reaction, the cell and/or extracellular reaction for it is real Existing clinical effectiveness is obligate.The physics of skin surface product is reduced to be occurred due to the Partial Resection of skin, and it is physically The part that skin is removed in relaxation area is directly removed.Further, since the wound healing response of delay, result in skin Then tighten up.Each pixelation cutout unit starts the obligate wound healing order in multiple stages.It is real in one embodiment Existing healing reaction includes three phases, as being previously herein described in detail.

The first stage of the order is the inflammation sexual stage, and in the inflammation sexual stage, the flailing action of mast cell is by group Amine is knitted to be discharged into " wound ".The release of histamine can cause the expansion of capillary bed and increase blood vessel enter it is extracellular Permeability in gap.This wound healing response at initial stage occurs in first day and intuitively will shown as on skin surface Erythema.

Start healing, the second stage of fibroplasia in the number of days of " wound ".During fibroplasia, fiber finer be present The migration and schizogamy of born of the same parents.Fibroplasia has two key features：The new deposition of collagen and the myofibroblast of wound Property shrink.From histology, the deposition of new collagen can be identified as the consolidation of corium and be thickened by microscope.Although This is static process, but the tensile strength of skin significantly increases.It is that the multidimensional for causing wound is received that myofibroblast, which shrinks, The dynamic physical processes of contracting.This process is due to that the competent cell of myofibroblast shrinks and the contraction in extracellular matrix The deposition of albumen.Generally, the effect that fibr tissue is formed be corium shrink and new collagen by the quiet of the framework tightened up The deposition of state supporting support.Clinical effectiveness is shown as within the several months with the dermostenosis of the smooth delay of texture.It is clinical Terminal is usually the more aobvious young skin crust of area for treatment.

The phase III of the wound healing response of delay and final stage are the stage of ripeness.During the stage of ripeness, due to The interconnecting for enhancing of (corium) collagen fiber matrix and cause the enhancing and remodeling of area for treatment.The final stage exists Start in six months to 12 months after " injury " and may extend up at least 1 year to 2 years.The small pixelation of skin Cutout unit is not being formed generally in the visually obvious scar for carrying out occurring in the case of larger surgery excision to skin In the case of normal dermis is kept during the stage of ripeness.Finally there are the phase of the epidermis discharged from epidermal growth hormone The stimulation and recovery of pass.

Figure 37 to Figure 42 shows the image for performing the operation to obtain from the pixel type that carries out in live animal according to embodiment. Embodiment described herein uses in the Proof of Concept research in animal model, and it demonstrates pixel type operation and produced Dermostenosis attractive in appearance is formed without visible scar.Study using live hog model, performed the operation under anaesthesia.Figure 37 is basis The image of the skin tatooed at the turning and intermediate point for treating cut-away area of embodiment.The edges of regions line of cutout unit Body is marked for postoperative evaluation, but embodiment not limited to this.Use the plate (for example, 10 × 10 pel arrays) of tape punching The operation is carried out, to specify the region cut off for substep.Carried out using biopsy punching machine (for example, diameter 1.5mm) Distribution excision.Figure 38 is according to the image of the postoperative skin cut-away area of embodiment.After pixel excision, make picture with Flexan films Elementization excision defect portion closure is (flatly).

11 days after surgery, the first intention in the region specified by tatooing of all cutout units, and carried out photograph and Dimensional measurement.Image when Figure 39 is postoperative 11 days according to embodiment, it shows that a phase is cured by the edge through measurement The cutout unit of conjunction.Then taken a picture within 29 days after surgery and dimensional measurement.When Figure 40 is postoperative 29 days according to embodiment Image, it shows the cutout unit of first intention by the edge through measurement and continues the stage of ripeness of the cut-away area of a phase. Image when Figure 41 is postoperative 29 days according to embodiment, it shows the cutout unit of first intention by the edge through measurement With the stage of ripeness of the cut-away area for the phase that continues.Repeat within 90 days photograph and dimensional measurement, and test section after surgery Domain skin touches very smooth.Image when Figure 42 is postoperative 90 days according to embodiment, it passes through the side through measurement Edge shows the cutout unit of first intention and continues the stage of ripeness of the cut-away area of a phase.

Embodiment includes a kind of equipment：The equipment includes housing, and the housing is configured to include skin graft knife system.The skin graft Knife system includes substrate and flap knife array.The flap knife array includes the multiple skin grafts being arranged on a configuration in substrate Knife.The substrate and the multiple flap knife are configured to deploy and be retracted in the housing from the housing.The multiple skin Piece knife is configured to produce multiple skin pixels being cut open in target site upon deployment.

Embodiment includes a kind of equipment, and the equipment includes housing, and housing is configured to include skin graft knife system；And skin graft Knife system includes substrate and flap knife array, wherein, flap knife array includes the multiple skin grafts being arranged on a configuration in substrate Knife, wherein, substrate and the multiple flap knife are configured to deploy and be retracted in housing from housing, wherein, the multiple skin Piece knife is configured to produce multiple skin pixels being cut open in target site upon deployment.

Housing is configured to removably be attached to female part.

Female part is the part of control device.

Control device includes proximal end and distal end, wherein, proximal end includes actuator mechanism, and distal end Portion includes female part.

Flap knife array configuration is unfolded into the startup in response to actuator mechanism.

The proximal end of control device is constructed to hand-held.

Skin graft knife system is arranged so that flap knife array response in the startup of actuator mechanism and from skin graft knife system exhibition Open and be recovered in skin graft knife system.

Skin graft knife system is arranged so that flap knife array response in the startup of actuator mechanism and from skin graft knife system exhibition Open.

Skin graft knife system is arranged so that flap knife array response is recovered to flap knife dress in the release of actuator mechanism In putting.

Control device is constructed to rear disposable type.

Control device is configured at least one of cleaned, sterilized and sterilized.

The equipment includes adhesiveness substrate, and the adhesiveness basal structure is into capturing the multiple skin pixels being cut open.

Skin graft knife system is configured to include adhesiveness substrate.

Housing is configured to include adhesiveness substrate.

Adhesiveness substrate includes flex substrate.

Adhesiveness substrate includes semi-porous film.

The equipment includes vacuum component.

Vacuum component is attached to housing.

Vacuum component is attached to skin graft knife system.

Vacuum component is attached to skin graft knife system via housing.

Vacuum component is configured to produce low-pressure area at least one of skin graft knife system and control device.

Low-pressure area is configured to extract out the multiple skin pixels being cut open.

Housing is configured to removably be attached to control device, wherein, vacuum component is attached to control device.

The equipment includes radio frequency (RF) part.

RF parts are configured to provide heat energy at least one of skin graft knife system and flap knife array.

RF parts are configured to provide vibrational energy at least one of skin graft knife system and flap knife array.

RF parts, which are configured to provide at least one of skin graft knife system and flap knife array, rotates energy.

RF parts are configured to provide acoustic energy at least one of skin graft knife system and flap knife array.

RF parts are attached to housing.

RF parts are attached to skin graft knife system.

RF parts are attached to skin graft knife system via housing.

RF parts are attached to flap knife array.

RF parts are attached to flap knife array via housing.

RF parts are attached at least one flap knife in flap knife array.

RF parts are attached at least one flap knife in flap knife array via housing.

Housing is configured to removably be attached to control device, wherein, RF parts are attached to control device.

The equipment includes vacuum component and radio frequency (RF) part, wherein, vacuum component is attached to skin graft knife system and housing At least one of, radio-frequency unit is attached at least one of skin graft knife system, flap knife array and housing.

Vacuum component is configured to produce low-pressure area at least one of skin graft knife system and housing.

RF parts are configured to provide energy at least one of skin graft knife system, flap knife array and housing.

Energy includes heat energy, vibrational energy, rotates at least one of energy and acoustic energy.

Target site includes receptor site, wherein, the skin pixels being cut open produce defect of skin at receptor site.

Target site includes donor site, wherein, the multiple skin pixels being cut open are obtained at donor site.

Target site includes receptor site, wherein, the skin pixels being cut open produce defect of skin at receptor site.

The equipment includes adhesiveness substrate, and adhesiveness basal structure is into capturing at donor site the multiple be cut open The multiple skin pixels being cut open simultaneously are transferred to receptor site by skin pixels.

Adhesiveness basal structure keeps the multiple quilt into during being transferred to receptor site and being applied at receptor site The relative positioning of the skin pixels of incision.

Adhesiveness basal structure into by the skin pixels being cut open be applied to receptor site at defect of skin.

Adhesiveness basal structure is aligned into by the skin pixels being cut open with the defect of skin at receptor site.

Adhesiveness basal structure lacks into the corresponding skin being inserted into each skin pixels being cut open at receptor site In damage.

The equipment includes at least one bandage, and at least one bandage is configured in target site application.

At least one bandage is configured to applying power to close target site.

At least one bandage is configured to apply directional power in target site to control closing direction.

At least one bandage includes the first bandage, and the first bandage is configured for applying at donor site.

At least one bandage includes the second bandage, and the second bandage is configured for applying at receptor site.

Skin graft knife system is configured to load transmission to the underlying skin surface for including target site, wherein, skin pixels It is cut open because of the application of load.

Flap knife array structure into by load transmission to including the underlying skin surface of target site, wherein, skin pixels It is cut open because of the application of load.

Skin graft knife system is constructed to rear disposable type.

Skin graft knife system is configured at least one of cleaned, sterilized and sterilized.

The equipment includes template, and structure of transvers plate is into for being positioned at target site.

Skin graft knife system is configured to be aligned with template.

Flap knife array structure is aligned into template.

Template is located on the skin surface of target site.

Template includes the indicant on the skin surface of target site.

Template includes guide plate, and guide plate is configured for being positioned at target site and including being set with a pattern Perforation.

Flap knife array is removably attached to skin graft knife system.

The rear disposable type of flap knife array.

The shape of each flap knife in flap knife array is ellipse.

The shape of each flap knife in flap knife array is circular.

The shape of each flap knife in flap knife array is semicircle.

The shape of each flap knife in flap knife array is square, rectangle and one of flat.

Each flap knife at least one flap knife includes inclined surface.

Each flap knife in the multiple flap knife includes at least one sharpened surface.

Each flap knife in the multiple flap knife includes at least one pin.

At least one pin includes multiple sophisticated pins including at least one.

Flap knife array produces the skin picture being cut open using at least one of force of piercing, impact and revolving force Element.

Flap knife array produces the skin pixels being cut open using radio frequency (RF) energy.

Flap knife array produces the skin pixels being cut open using vibrational energy.

At least one flap knife in flap knife array includes through hole.

At least one diameter dimension of each flap knife in flap knife array is approximately at 0.5 millimeter to 4.0 millimeters In the range of.

The equipment includes guide plate, and guide plate is configured for as Template Location in target site, wherein, guide plate Including the perforation set with a pattern.

Flap knife array structure is aligned into the perforation in guide plate.

Flap knife array is applied to donor site via the perforation in guide plate, wherein, the multiple skin pixels are cut Open.

Flap knife array is applied to receptor site via the perforation in guide plate, wherein, generate multiple defects of skin.

Target site includes donor site and receptor site.

The multiple skin pixels being cut open and the multiple defect of skin produce according to the pattern.

The equipment includes adhesiveness substrate, and adhesiveness basal structure is into capturing at donor site the multiple be cut open The multiple skin pixels being cut open simultaneously are transferred to receptor site by skin pixels.

Adhesiveness basal structure keeps the multiple quilt into during being transferred to receptor site and being applied at receptor site The relative positioning of the skin pixels of incision.

Flap knife array is cut open directly through perforation applied to donor site and skin pixels.

Flap knife array produces directly through perforation applied to receptor site and defect of skin.

Guide plate is adhesiveness, it is rigid, semirigid, conformal, non-conformal and non-deformable at least One.

Guide plate includes at least one of metal, plastics, polymer and membrane material.

Guide plate is configured to the skin surface of at least one of load transmission to donor site and receptor site.

Guide plate is positioned directly on the skin surface of target site.

Guide plate is configured to extrude the multiple skin pixels being cut open.

The multiple skin pixels are extruded in response to the load applied through perforation.

The multiple skin pixels are extruded in response to the load applied through the skin surface being cut open.

The equipment includes cutting element.

The skin pixels being cut open are crosscutting by cutting element.

The equipment includes adhesiveness substrate, the skin pixels that adhesiveness basal structure is cut open into capture.

Cutting element is attached to framework.

Framework is attached to guide plate, wherein, guide plate is configured to the guide member of skin graft knife system.

Adhesiveness substrate is attached at least one of framework and guide plate.

The skin pixels being cut open include hair follicle.

Defect of skin is configured to promote the neovascularization in the skin pixels being cut open at insertion receptor site.

Defect of skin is configured to promote the wound healing reaction in the skin pixels being cut open at insertion receptor site.

Embodiment includes a kind of equipment, and the equipment includes housing, and housing includes skin graft knife system；And skin graft knife system Including flap knife array, flap knife array includes the multiple flap knifes set with a pattern, wherein, the multiple flap knife can Deploy from housing to produce multiple skin pixels being cut open in target site.

Embodiment includes a kind of equipment, and the equipment includes housing, and housing includes skin graft knife system.Skin graft knife system includes Flap knife array, flap knife array include the multiple flap knifes set with a pattern.The multiple flap knife can be from housing exhibition Open to produce multiple skin pixels being cut open in target site.

Embodiment includes a kind of system, and the system includes control device, and control device includes proximal end and distal end Portion.Proximal end includes actuator mechanism, and distal end includes female part.The system includes skin graft knife system, flap knife Device is configured to removably be attached to the female part of control device.Skin graft knife system includes substrate and flap knife battle array Row, flap knife array include the multiple flap knifes being arranged on a configuration in substrate.Substrate and the multiple flap knife are configured to It is unfolded in response to the startup of actuator mechanism.The multiple flap knife is configured to more in target site generation upon deployment The individual skin pixels being cut open.

Embodiment includes a kind of system, and the system includes：Control device, control device include proximal end and distal end Portion, wherein, proximal end includes actuator mechanism, and distal end includes female part；And skin graft knife system, flap knife dress The female part for being configured to removably be attached to control device is put, wherein, skin graft knife system includes substrate and flap knife Array, flap knife array include the multiple flap knifes being arranged on a configuration in substrate, wherein, substrate and the multiple flap knife It is configured to the startup of actuator mechanism and is unfolded, wherein, the multiple flap knife is configured to upon deployment in target Position produces multiple skin pixels being cut open.

The proximal end of control device is constructed to hand-held.

Target site includes receptor site, wherein, the skin pixels being cut open produce defect of skin at receptor site.

Target site includes donor site, wherein, the multiple skin pixels being cut open are obtained at donor site.

Target site includes receptor site, wherein, the skin pixels being cut open produce defect of skin at receptor site.

The system includes adhesiveness substrate, and adhesiveness basal structure is into capturing at donor site the multiple be cut open The multiple skin pixels being cut open simultaneously are transferred to receptor site by skin pixels.

Adhesiveness basal structure keeps the multiple quilt into during being transferred to receptor site and being applied at receptor site The relative positioning of the skin pixels of incision.

Adhesiveness basal structure into by the skin pixels being cut open be applied to receptor site at defect of skin.

Adhesiveness basal structure is aligned into by the skin pixels being cut open with the defect of skin at receptor site.

Adhesiveness basal structure lacks into the corresponding skin being inserted into each skin pixels being cut open at receptor site In damage.

The system includes at least one bandage, and at least one bandage is configured in target site application.

At least one bandage is configured to applying power to close target site.

At least one bandage is configured to apply directional power in target site to control closing direction.

At least one bandage includes the first bandage, and the first bandage is configured for applying at donor site.

At least one bandage includes the second bandage, and the second bandage is configured for applying at receptor site.

The system includes adhesiveness substrate, and adhesiveness basal structure is into capturing the multiple skin pixels being cut open.

Skin graft knife system is configured to include adhesiveness substrate.

Adhesiveness substrate includes flex substrate.

Adhesiveness substrate includes semi-porous film.

Skin graft knife system is arranged so that flap knife array response in the startup of actuator mechanism and from skin graft knife system exhibition Open and be recovered in skin graft knife system.

Skin graft knife system is arranged so that flap knife array response in the startup of actuator mechanism and from skin graft knife system exhibition Open.

Skin graft knife system is arranged so that flap knife array response is recovered to flap knife dress in the release of actuator mechanism In putting.

Skin graft knife system is configured to load transmission to the underlying skin surface for including target site, wherein, skin pixels It is cut open because of the application of load.

Flap knife array structure into by load transmission to including the underlying skin surface of target site, wherein, skin pixels It is cut open because of the application of load.

Skin graft knife system is constructed to rear disposable type.

Skin graft knife system is configured at least one of cleaned, sterilized and sterilized.

Control device is constructed to rear disposable type.

Control device is configured at least one of cleaned, sterilized and sterilized.

The system includes template, and structure of transvers plate is into for being positioned at target site.

Skin graft knife system is configured to be aligned with template.

Flap knife array structure is aligned into template.

Template is located on the skin surface of target site.

Template includes the indicant on the skin surface of target site.

Template includes guide plate, and guide plate is configured for being positioned at target site and including being set with a pattern Perforation.

Flap knife array is removably attached to skin graft knife system.

The rear disposable type of flap knife array.

The shape of each flap knife in flap knife array is ellipse.

143. according to the system of claim 106, wherein, the shape of each flap knife in flap knife array is circular.

The shape of each flap knife in flap knife array is semicircle.

The shape of each flap knife in flap knife array is square, rectangle and one of flat.

Each flap knife at least one flap knife includes inclined surface.

Each flap knife in the multiple flap knife includes at least one sharpened surface.

Each flap knife in the multiple flap knife includes at least one pin.

At least one pin includes multiple sophisticated pins including at least one.

Flap knife array produces the skin picture being cut open using at least one of force of piercing, impact and revolving force Element.

Flap knife array produces the skin pixels being cut open using radio frequency (RF) energy.

Flap knife array produces the skin pixels being cut open using vibrational energy.

At least one flap knife in flap knife array includes through hole.

At least one diameter dimension of each flap knife in flap knife array is approximately at 0.5 millimeter to 4.0 millimeters In the range of.

The system includes vacuum component.

Vacuum component is attached to control device.

Vacuum component is attached to skin graft knife system.

Vacuum component is attached to skin graft knife system via control device.

Vacuum component is configured to produce low-pressure area at least one of skin graft knife system and control device.

Low-pressure area is configured to extract out the multiple skin pixels being cut open.

The system includes radio frequency (RF) part.

RF parts are configured to provide heat energy at least one of skin graft knife system, flap knife array and control device.

RF parts are configured to provide vibrational energy at least one of skin graft knife system, flap knife array and control device.

RF parts, which are configured to provide at least one of skin graft knife system, flap knife array and control device, rotates energy.

RF parts are configured to provide acoustic energy at least one of skin graft knife system, flap knife array and control device.

RF parts are attached to control device.

RF parts are attached to skin graft knife system.

RF parts are attached to skin graft knife system via control device.

RF parts are attached to flap knife array.

RF parts are attached to flap knife array via control device.

RF parts are attached at least one flap knife in flap knife array.

RF parts are attached at least one flap knife in flap knife array via control device.

The system includes vacuum component and radio frequency (RF) part, wherein, vacuum component is attached to skin graft knife system and control At least one of device, radio-frequency unit are attached at least one of skin graft knife system, flap knife array and control device.

Vacuum component is configured to produce low-pressure area at least one of skin graft knife system and control device.

RF parts are configured to provide energy at least one of skin graft knife system, flap knife array and control device.

Energy includes heat energy, vibrational energy, rotates at least one of energy and acoustic energy.

The system includes guide plate, and guide plate is configured for as Template Location in target site, wherein, guide plate Including the perforation set with a pattern.

Flap knife array structure is aligned into the perforation in guide plate.

Flap knife array is applied to donor site via the perforation in guide plate, wherein, the multiple skin pixels are cut Open.

Flap knife array is applied to receptor site via the perforation in guide plate, wherein, multiple defects of skin produce.

Target site includes donor site and receptor site.

The multiple skin pixels being cut open and the multiple defect of skin produce according to pattern.

The system includes adhesiveness substrate, and adhesiveness basal structure is into capturing at donor site the multiple be cut open The multiple skin pixels being cut open simultaneously are transferred to receptor site by skin pixels.

Adhesiveness basal structure keeps the multiple quilt into during being transferred to receptor site and being applied at receptor site The relative positioning of the skin pixels of incision.

Flap knife array is cut open directly through perforation applied to donor site and skin pixels.

Flap knife array produces directly through perforation applied to receptor site and defect of skin.

Guide plate is adhesiveness, it is rigid, semirigid, conformal, non-conformal and non-deformable at least One.

Guide plate includes at least one of metal, plastics, polymer and membrane material.

Guide plate is configured to the skin surface of at least one of load transmission to donor site and receptor site.

Guide plate is positioned directly on the skin surface of target site.

Guide plate is configured to extrude the multiple skin pixels being cut open.

The multiple skin pixels are extruded in response to the load applied through perforation.

The multiple skin pixels are extruded in response to the load applied through the skin surface being cut open.

The system includes cutting element.

The skin pixels being cut open are crosscutting by cutting element.

The skin pixels that adhesiveness basal structure is cut open into capture.

Cutting element is attached to framework.

Framework is attached to guide plate, wherein, guide plate is configured to the guide member of skin graft knife system.

Adhesiveness substrate is attached at least one of framework and guide plate.

The skin pixels being cut open include hair follicle.

Defect of skin is configured to promote the neovascularization in the skin pixels being cut open at insertion receptor site.

Defect of skin is configured to promote the wound healing reaction in the skin pixels being cut open of insertion receptor site.

Embodiment includes a kind of system, and the system includes control device.The system includes removably coupling To the skin graft knife system of control device.Skin graft knife system includes flap knife array, and flap knife array includes what is set with a pattern Multiple flap knifes.The multiple flap knife is configured to be deployed and shunk and in mesh by the startup that control device is carried out Mark position and produce multiple skin pixels being cut open.

Embodiment includes a kind of system, and the system includes control device and is removably attached to control dress The skin graft knife system put, wherein, skin graft knife system includes flap knife array, and flap knife array is included with the multiple of pattern setting Flap knife, wherein, the multiple flap knife be configured to by control device carry out startup and deploy and shrink and Target site produces multiple skin pixels being cut open.

Embodiment includes a kind of system, and the system includes control device, and control device includes actuator mechanism.The system Including skin graft knife system, skin graft knife system is configured to removably be attached to control device.Skin graft knife system includes base Bottom and flap knife array, flap knife array include the multiple flap knifes being arranged on a pattern in substrate.Substrate and the multiple Flap knife is configured to the startup of actuator mechanism and is deployed and at least one of shunk.The multiple flap knife It is configured to produce multiple skin pixels being cut open in target site upon deployment.

Embodiment includes a kind of system, and the system includes：Control device, control device include actuator mechanism；And Skin graft knife system, skin graft knife system are configured to removably be attached to control device, wherein, skin graft knife system includes base Bottom and flap knife array, flap knife array include being arranged on multiple flap knifes in substrate with a pattern, wherein, substrate and described Multiple flap knifes are configured to the startup of actuator mechanism and are deployed and at least one of shunk, wherein, it is described Multiple flap knifes are configured to produce multiple skin pixels being cut open in target site upon deployment.

Embodiment includes a kind of system, and the system includes housing, and housing is configured to include skin graft knife system.Flap knife fills Put including substrate and flap knife array.Flap knife array includes the multiple flap knifes being arranged on a configuration in substrate.Substrate and The multiple flap knife is configured to deploy and be retracted in housing from housing.The multiple flap knife be configured to upon deployment in Target site produces multiple skin pixels being cut open.The system includes vacuum component, and vacuum component is configured to neighbouring skin graft Knife system produces low-pressure area.

Embodiment includes a kind of system, and the system includes：Housing, housing are configured to include skin graft knife system；Flap knife Device includes substrate and flap knife array, wherein, flap knife array includes the multiple flap knifes being arranged on a configuration in substrate, Wherein, substrate and the multiple flap knife are configured to deploy and be retracted in housing from housing, wherein, the multiple flap knife It is configured to produce multiple skin pixels being cut open in target site upon deployment；And vacuum component, vacuum component construction Low-pressure area is produced into neighbouring skin graft knife system.

Vacuum component is attached to housing.

Vacuum component is attached to skin graft knife system.

Vacuum component is attached to skin graft knife system via housing.

Vacuum component is configured to produce low-pressure area in housing.

Low-pressure area is configured to extract out the multiple skin pixels being cut open.

Housing is configured to removably be attached to female part.

Female part is the part of control device.

Control device includes proximal end and distal end, wherein, proximal end includes actuator mechanism, and distal end Portion includes female part.

Flap knife array configuration is unfolded into the startup in response to actuator mechanism.

The proximal end of control device is constructed to hand-held.

Skin graft knife system is arranged so that flap knife array response in the startup of actuator mechanism and from skin graft knife system exhibition Open and be recovered in skin graft knife system.

Skin graft knife system is arranged so that flap knife array response in the startup of actuator mechanism and from skin graft knife system exhibition Open.

Skin graft knife system is arranged so that flap knife array response is recovered to flap knife dress in the release of actuator mechanism In putting.

Control device is constructed to rear disposable type.

Control device is configured at least one of cleaned, sterilized and sterilized.

The system includes adhesiveness substrate, and adhesiveness basal structure is into capturing the multiple skin pixels being cut open.

Skin graft knife system is configured to include adhesiveness substrate.

Housing is configured to include adhesiveness substrate.

Adhesiveness substrate includes flex substrate.

Adhesiveness substrate includes semi-porous film.

The system includes radio frequency (RF) part.

RF parts are configured to provide heat energy at least one of skin graft knife system and flap knife array.

RF parts are configured to provide vibrational energy at least one of skin graft knife system and flap knife array.

RF parts, which are configured to provide at least one of skin graft knife system and flap knife array, rotates energy.

RF parts are configured to provide acoustic energy at least one of skin graft knife system and flap knife array.

RF parts are attached to housing.

RF parts are attached to skin graft knife system.

RF parts are attached to skin graft knife system via housing.

RF parts are attached to flap knife array.

RF parts are attached to flap knife array via housing.

RF parts are attached at least one flap knife in flap knife array.

RF parts are attached at least one flap knife in flap knife array via housing.

Housing is configured to removably be attached to control device, wherein, RF parts are attached to control device.

Target site includes receptor site, wherein, the skin pixels being cut open produce defect of skin at receptor site.

Target site includes donor site, wherein, the multiple skin pixels being cut open are obtained at donor site.

Target site includes receptor site, wherein, the skin pixels being cut open produce defect of skin at receptor site.

The system includes adhesiveness substrate, and adhesiveness basal structure is into capturing at donor site the multiple be cut open The multiple skin pixels being cut open simultaneously are transferred to receptor site by skin pixels.

Adhesiveness basal structure keeps the multiple quilt into during being transferred to receptor site and being applied at receptor site The relative positioning of the skin pixels of incision.

Adhesiveness basal structure into by the skin pixels being cut open be applied to receptor site at defect of skin.

Adhesiveness basal structure is aligned into by the skin pixels being cut open with the defect of skin at receptor site.

Adhesiveness basal structure lacks into the corresponding skin being inserted into each skin pixels being cut open at receptor site In damage.

The system includes at least one bandage, and at least one bandage is configured in target site application.

At least one bandage is configured to applying power to close target site.

At least one bandage is configured to apply directional power in target site to control closing direction.

At least one bandage includes the first bandage, and the first bandage is configured to apply at donor site.

At least one bandage includes the second bandage, and the second bandage is configured for applying at receptor site.

Skin graft knife system is configured to load transmission to the underlying skin surface for including target site, wherein, skin pixels It is cut open because of the application of load.

Flap knife array structure into by load transmission to including the underlying skin surface of target site, wherein, skin pixels It is cut open because of the application of load.

Skin graft knife system is constructed to rear disposable type.

Skin graft knife system is configured at least one of cleaned, sterilized and sterilized.

The system includes template, and structure of transvers plate is into for being positioned at target site.

Skin graft knife system is configured to be aligned with template.

Flap knife array structure is aligned into template.

Template is located on the skin surface of target site.

Template includes the indicant on the skin surface of target site.

Template includes guide plate, and guide plate is configured for being positioned at target site and including being set with a pattern Perforation.

Flap knife array is removably attached to skin graft knife system.

The rear disposable type of flap knife array.

The shape of each flap knife in flap knife array is ellipse.

The shape of each flap knife in flap knife array is circular.

The shape of each flap knife in flap knife array is semicircle.

The shape of each flap knife in flap knife array is square, rectangle and one of flat.

Each flap knife at least one flap knife includes inclined surface.

Each flap knife in the multiple flap knife includes at least one sharpened surface.

Each flap knife in the multiple flap knife includes at least one pin.

At least one pin includes multiple sophisticated pins including at least one.

Flap knife array produces the skin picture being cut open using at least one of force of piercing, impact and revolving force Element.

Flap knife array produces the skin pixels being cut open using radio frequency (RF) energy.

Flap knife array produces the skin pixels being cut open using vibrational energy.

At least one flap knife in flap knife array includes through hole.

At least one diameter dimension of each flap knife in flap knife array is approximately at 0.5 millimeter to 4.0 millimeters In the range of.

The system includes guide plate, and guide plate is configured as Template Location in target site, wherein, guide plate includes The perforation set with a pattern.

Flap knife array structure is aligned into the perforation in guide plate.

Flap knife array is applied to donor site via the perforation in guide plate, wherein, the multiple skin pixels are cut Open.

Flap knife array is applied to receptor site via the perforation in guide plate, wherein, generate multiple defects of skin.

Target site includes donor site and receptor site.

The multiple skin pixels being cut open and the multiple defect of skin produce according to pattern.

The system includes adhesiveness substrate, and adhesiveness basal structure is into capturing at donor site the multiple be cut open The multiple skin pixels being cut open simultaneously are transferred to receptor site by skin pixels.

Adhesiveness basal structure keeps the multiple quilt into during being transferred to receptor site and being applied at receptor site The relative positioning of the skin pixels of incision.

Flap knife array is cut open directly through perforation applied to donor site and skin pixels.

Flap knife array produces directly through perforation applied to receptor site and defect of skin.

Guide plate is adhesiveness, it is rigid, semirigid, conformal, non-conformal and non-deformable at least One.

Guide plate includes at least one of metal, plastics, polymer and membrane material.

Guide plate is configured to the skin surface of at least one of load transmission to donor site and receptor site.

Guide plate is positioned directly on the skin surface of target site.

Guide plate is configured to extrude the multiple skin pixels being cut open.

The multiple skin pixels are extruded in response to the load applied through perforation.

The multiple skin pixels are extruded in response to the load applied through the skin surface being cut open.

The system includes cutting element.

The skin pixels being cut open are crosscutting by cutting element.

The system includes adhesiveness substrate, the skin pixels that adhesiveness basal structure is cut open into capture.

Cutting element is attached to framework.

Framework is attached to guide plate, wherein, guide plate is configured to the guide member of skin graft knife system.

Adhesiveness substrate is attached at least one of framework and guide plate.

The skin pixels being cut open include hair follicle.

Defect of skin is configured to promote the neovascularization in the skin pixels being cut open at insertion receptor site.

Defect of skin is configured to promote the wound healing reaction in the skin pixels being cut open at insertion receptor site.

Embodiment includes a kind of system, and the system includes housing, and housing includes skin graft knife system.Skin graft knife system includes Flap knife array, flap knife array include the multiple flap knifes set with a pattern.The multiple flap knife can be from housing exhibition Open to produce multiple skin pixels being cut open in target site.The system includes vacuum component, and vacuum component is configured to neighbour Nearly skin graft knife system produces low-pressure area.

Embodiment includes a kind of system, and the system includes：Housing, housing include skin graft knife system；And flap knife fills To put including flap knife array, flap knife array includes the multiple flap knifes set with a pattern, wherein, the multiple flap knife energy It is enough to deploy from housing to produce multiple skin pixels being cut open in target site；And vacuum component, vacuum component construction Low-pressure area is produced into neighbouring skin graft knife system.

Embodiment includes a kind of method, and this method includes the housing comprising skin graft knife system being positioned at target site Place.Skin graft knife system includes substrate and flap knife array.Flap knife array includes the multiple skins being arranged on a configuration in substrate Piece knife.This method includes making flap knife array be deployed into the tissue of target site from housing and produce in target site Multiple skin pixels being cut open.This method includes making flap knife array be retracted in housing from target site.

Embodiment includes a kind of method, and this method includes：Housing including skin graft knife system is positioned at target site Place, wherein, skin graft knife system includes substrate and flap knife array, wherein, flap knife array includes being arranged on substrate with a configuration On multiple flap knifes；Flap knife array is set to be deployed into the tissue of target site from housing and be produced in target site Multiple skin pixels being cut open；And flap knife array is set to be retracted to from target site in housing.

This method includes housing being attached to female part, and female part is the part of control device.

Control device includes proximal end and distal end, wherein, proximal end includes actuator mechanism, and distal end Portion includes female part.

The expansion includes making flap knife array response in the startup of actuator mechanism deploy.

Flap knife array response is in the startup of actuator mechanism.

Described shrink includes making flap knife array response shrink in the release of actuator mechanism.

The proximal end of control device is constructed to hand-held.

This method includes making skin graft knife system with female part disconnection couple and abandons skin graft knife system.

This method includes at least one of cleaning control device, sterilized and being sterilized.

This method captures the multiple skin pixels being cut open including the use of adhesiveness substrate.

Skin graft knife system includes adhesiveness substrate.

Housing includes adhesiveness substrate.

Adhesiveness substrate includes flex substrate.

Adhesiveness substrate includes semi-porous film.

This method includes obtaining the multiple skin pixels being cut open.

Described obtain includes extracting out the multiple skin pixels being cut open.

The acquisition, which is included at least one of skin graft knife system and housing, produces low-pressure area.

Low-pressure area is produced including the use of vacuum component.

Vacuum component is attached to housing.

Vacuum component is attached to skin graft knife system.

Vacuum component is attached to skin graft knife system via housing.

Housing is configured to removably be attached to control device, wherein, vacuum component is attached to control device.

Producing the multiple skin pixels being cut open is included into skin graft knife system, flap knife array and housing at least One provides energy.

Energy is provided including the use of radio frequency (RF) part.

Energy includes heat energy, vibrational energy, rotates at least one of energy and acoustic energy.

There is provided energy includes providing heat energy at least one of skin graft knife system and flap knife array.

There is provided energy includes providing vibrational energy at least one of skin graft knife system and flap knife array.

There is provided energy includes providing rotation energy at least one of skin graft knife system and flap knife array.

There is provided energy includes providing acoustic energy at least one of skin graft knife system and flap knife array.

RF parts are attached to housing.

RF parts are attached to skin graft knife system.

RF parts are attached to skin graft knife system via housing.

RF parts are attached to flap knife array.

RF parts are attached to flap knife array via housing.

RF parts are attached at least one flap knife in flap knife array.

RF parts are attached at least one flap knife in flap knife array via housing.

Housing is configured to removably be attached to control device, wherein, RF parts are attached to control device.

This method obtains the multiple skin pixels being cut open including the use of vacuum component, wherein, produce described more The individual skin pixels being cut open are using radio frequency (RF) energy.

Vacuum component is configured to produce low-pressure area at least one of skin graft knife system and housing.

RF parts are configured to provide energy at least one of skin graft knife system, flap knife array and housing.

Energy includes heat energy, vibrational energy, rotates at least one of energy and acoustic energy.

Target site includes receptor site, wherein, the skin pixels being cut open produce defect of skin at receptor site.

Target site includes donor site, wherein, the multiple skin pixels being cut open are obtained at donor site.

Target site includes receptor site, wherein, the skin pixels being cut open produce defect of skin at receptor site.

This method captures the multiple skin pixels being cut open including the use of adhesiveness substrate and will be the multiple The skin pixels being cut open are transferred to receptor site.

This method keeps the multiple skin pixels being cut open including adhesiveness substrate during receptor site is transferred to Relative positioning.

The multiple skin pixels being cut open that this method includes self-sticking substrate in the future are applied at receptor site Defect of skin.

This method is including the use of adhesiveness substrate by the skin at the multiple skin pixels being cut open and receptor site Skin defect is aligned.

The skin pixels that are each cut open of this method including self-sticking substrate in the future are inserted into pair at receptor site In the defect of skin answered.

This method is included in target site and applies at least one bandage.

Include applying power using at least one bandage to close target site.

It is included in target site using at least one bandage and applies directional power to control closing direction.

It is included in using at least one bandage at donor site and applies the first bandage.

It is included in using at least one bandage at receptor site and applies the second bandage.

Producing the multiple skin pixels being cut open includes load being transferred to including target portion via skin graft knife system The underlying skin surface of position, wherein, skin pixels are cut by applying load.

Producing the multiple skin pixels being cut open includes load being transferred to including target portion via flap knife array The underlying skin surface of position, wherein, skin pixels are cut by applying load.

Skin graft knife system is constructed to rear disposable type.

Skin graft knife system is configured at least one of cleaned, sterilized and sterilized.

This method is included Template Location in target site.

This method includes skin graft knife system being aligned with template.

This method includes flap knife array being aligned with template.

The positioning is included Template Location on the skin surface of target site.

Template includes the indicant on the skin surface of target site.

Template includes guide plate, and guide plate is configured for being positioned at target site and including being set with a pattern Perforation.

This method includes flap knife array being removably attached to skin graft knife system.

The rear disposable type of flap knife array.

The shape of each flap knife in flap knife array is ellipse.

The shape of each flap knife in flap knife array is circular.

The shape of each flap knife in flap knife array is semicircle.

The shape of each flap knife in flap knife array is square, rectangle and one of flat.

Each flap knife in the multiple flap knife includes inclined surface.

Each flap knife in the multiple flap knife includes at least one sharpened surface.

Each flap knife in the multiple flap knife includes at least one pin.

At least one pin includes multiple sophisticated pins including at least one.

The multiple pixel being cut open is produced to produce using at least one of force of piercing, impact and revolving force It is raw.

The multiple pixel being cut open is produced using radio frequency (RF) energy to produce.

The multiple pixel being cut open is produced to produce using vibrational energy.

At least one flap knife in flap knife array includes through hole.

At least one diameter dimension of each flap knife in flap knife array is approximately at 0.5 millimeter to 4.0 millimeters In the range of.

This method include using guide plate as Template Location in target site, wherein, guide plate with a pattern including being set The perforation put.

This method includes flap knife array being aligned with the perforation in guide plate.

This method includes flap knife array being applied to donor site via the perforation in guide plate, wherein, it is the multiple Skin pixels are cut open.

This method includes flap knife array being applied to receptor site via the perforation in guide plate, wherein, generate more Individual defect of skin.

Target site includes donor site and receptor site.

This method includes producing the multiple skin pixels being cut open and the multiple defect of skin according to pattern.

This method captures the multiple skin pixels being cut open simultaneously using adhesiveness substrate at donor site And the multiple skin pixels being cut open are transferred to receptor site.

This method includes keeping institute using adhesiveness substrate during being transferred to receptor site and applying at receptor site State the relative positioning of multiple skin pixels being cut open.

This method includes flap knife array being applied to donor site directly through perforation and cuts skin pixels.

This method includes directly through perforation producing flap knife array applied to receptor site and defect of skin.

Guide plate is adhesiveness, it is rigid, semirigid, conformal, non-conformal and non-deformable at least One.

Guide plate includes at least one of metal, plastics, polymer and membrane material.

Guide plate is configured to the skin surface of at least one of load transmission to donor site and receptor site.

This method includes guide plate being positioned directly on the skin surface of target site.

This method extrudes the multiple skin pixels being cut open including the use of guide plate.

This method includes the load in response to being applied and extrudes the multiple skin pixels through perforation.

This method includes the load in response to being applied and the multiple skin pixels is passed through to the skin surface being cut open Extrusion.

The multiple skin pixels being cut open are produced to cut using cutting element.

This method carries out crosscutting using cutting element to the skin pixels being cut open.

This method captures the skin pixels being cut open using adhesiveness substrate.

Cutting element is attached to framework.

Framework is attached to guide plate, wherein, guide plate is configured to the guide member of skin graft knife system.

Adhesiveness substrate is attached at least one of framework and guide plate.

The skin pixels being cut open include hair follicle.

This method promotes the new blood inserted in the skin pixels being cut open at receptor site including the use of defect of skin Pipe is formed.

This method is cured including the use of defect of skin to promote to insert the wound in the skin pixels being cut open of receptor site Close reaction.

Embodiment includes a kind of method, and this method includes：Formed and coupled between control device and skin graft knife system, its In, control device includes actuator, wherein, skin graft knife system includes flap knife array, and flap knife array includes setting with a pattern The multiple flap knifes put；Skin graft knife system is aligned in target site；And by making flap knife array be deployed into target portion Multiple skin pixels being cut open and multiple defects of skin are produced in tissue at position, wherein, flap knife array response is in cause Move the startup of device and deploy.

Embodiment includes a kind of method, and this method includes：Formed and coupled between control device and skin graft knife system, its In, control device includes actuator, wherein, skin graft knife system includes flap knife array, and flap knife array includes setting with a pattern The multiple flap knifes put；Skin graft knife system is aligned in target site；And by making flap knife array be deployed into target portion Multiple skin pixels being cut open and multiple defects of skin are produced in tissue at position, wherein, flap knife array response is in cause Move the startup of device and deploy.

Embodiment includes a kind of method, and this method includes：Housing is positioned at target site, wherein, housing includes Flap knife array, flap knife array include the multiple flap knifes set with a pattern；Flap knife array is set to be deployed into target site In the tissue at place；When target site is donor site, multiple skin pixels being cut open are produced in target site；Work as target When position is receptor site, multiple defects of skin are produced in target site；And obtain the multiple skin picture being cut open Element.

Embodiment includes a kind of method, and this method includes：Housing is positioned at target site, wherein, housing includes Flap knife array, flap knife array include the multiple flap knifes set with a pattern；Flap knife array is set to be deployed into target site In the tissue at place；When target site is donor site, multiple skin pixels being cut open are produced in target site；Work as target When position is receptor site, multiple defects of skin are produced in target site；And obtain the multiple skin picture being cut open Element.

Embodiment includes a kind of method, and this method includes：Housing is positioned at donor site, wherein, housing includes Flap knife array, flap knife array include the multiple flap knifes set with a pattern；Flap knife array is set to be deployed into donor site In the tissue at place and produce multiple skin pixels being cut open；The multiple skin picture being cut open is captured at donor site The skin pixels being cut open simultaneously are transferred to acceptor by element；Housing is positioned at receptor site, and deploys flap knife array In tissue at receptor site and generate multiple defects of skin；And by the multiple skin pixels application being cut open Defect of skin at receptor site.

Embodiment includes a kind of method, and this method includes：Housing is positioned at donor site, wherein, housing includes Flap knife array, flap knife array include the multiple flap knifes set with a pattern；Flap knife array is set to be deployed into donor site In the tissue at place and produce multiple skin pixels being cut open；The multiple skin picture being cut open is captured at donor site The skin pixels being cut open simultaneously are transferred to acceptor by element；Housing is positioned at receptor site, and deploys flap knife array In tissue at receptor site and generate multiple defects of skin；And by the multiple skin pixels application being cut open Defect of skin at receptor site.

Embodiment includes a kind of method, and this method includes：Housing is configured to include skin graft knife system；And by skin graft Knife system is configured to include substrate and flap knife array, wherein, flap knife array structure with a configuration into including being arranged on substrate On multiple flap knifes, wherein, substrate and the multiple flap knife are configured to deploy and be retracted in housing from housing, its In, the multiple flap knife is configured to produce multiple skin pixels being cut open in target site upon deployment.

Embodiment includes a kind of method, and this method includes：Housing is configured to include skin graft knife system；And by skin graft Knife system is configured to include substrate and flap knife array, wherein, flap knife array structure with a configuration into including being arranged on substrate On multiple flap knifes, wherein, substrate and the multiple flap knife are configured to deploy and be retracted in housing from housing, its In, the multiple flap knife is configured to produce multiple skin pixels being cut open in target site upon deployment.

This method includes being configured to housing to be removably attached to female part.

Female part is the part of control device.

This method includes being configured to control device to include proximal end and distal end, wherein, proximal end includes causing Dong Qi mechanisms, and distal end includes female part.

This method includes flap knife array configuration being unfolded into the startup in response to actuator mechanism.

This method includes the proximal end of control device being constructed to hand-held.

This method include by skin graft knife system be arranged so that flap knife array response in the startup of actuator mechanism and from Skin graft knife system deploys and is recovered in skin graft knife system.

This method include by skin graft knife system be arranged so that flap knife array response in the startup of actuator mechanism and from Skin graft knife system deploys.

This method includes skin graft knife system being arranged so that flap knife array response is received in the release of actuator mechanism Return in skin graft knife system.

This method includes control device being constructed to rear disposable type.

This method includes control device being configured at least one of cleaned, sterilized and sterilized.

This method is included adhesiveness basal structure into capturing the multiple skin pixels being cut open.

This method includes being configured to skin graft knife system to include adhesiveness substrate.

This method includes being configured to housing to include adhesiveness substrate.

Adhesiveness substrate includes flex substrate.

Adhesiveness substrate includes semi-porous film.

This method includes at least one of housing, skin graft knife system and flap knife array being configured for and vacuum Part is used together.

This method includes being configured for housing to be attached to vacuum component.

This method includes being configured for skin graft knife system to be attached to the vacuum for being attached to the skin graft knife system Part.

This method includes being configured for being attached to vacuum component via housing by skin graft knife system.

This method includes being configured to include low-pressure area by least one of skin graft knife system and control device.

This method includes being configured to low-pressure area to extract the multiple skin pixels being cut open out.

This method includes being configured to housing to be removably attached to control device, wherein, vacuum component connection To control device.

This method includes at least one of housing, skin graft knife system and flap knife array being configured for and radio frequency (RF) part is used together.

This method includes being configured to RF parts to provide heat energy at least one of skin graft knife system and flap knife array.

This method includes being configured to RF parts to provide vibration at least one of skin graft knife system and flap knife array Energy.

This method includes being configured to RF parts to provide rotation at least one of skin graft knife system and flap knife array Energy.

This method includes being configured to RF parts to provide acoustic energy at least one of skin graft knife system and flap knife array.

This method includes RF parts being attached to housing.

This method includes RF parts being attached to skin graft knife system.

This method includes RF parts being attached to skin graft knife system via housing.

This method includes RF parts being attached to flap knife array.

This method includes RF parts being attached to flap knife array via housing.

This method includes at least one flap knife being attached to RF parts in flap knife array.

This method includes at least one flap knife being attached to RF parts via housing in flap knife array.

This method includes being configured to housing to be removably attached to control device, wherein, RF parts are attached to Control device.

This method includes vacuum component being attached at least one of skin graft knife system and housing, and by radio frequency (RF) Part is attached at least one of skin graft knife system, flap knife array and housing.

This method includes being configured to include low-pressure area by least one of skin graft knife system and housing.

This method includes being configured to receive by least one of skin graft knife system, flap knife array and housing coming from RF portions The energy of part.

Energy includes heat energy, vibrational energy, rotates at least one of energy and acoustic energy.

Target site includes receptor site, wherein, the skin pixels being cut open produce defect of skin at receptor site.

Target site includes donor site, wherein, the multiple skin pixels being cut open are obtained at donor site.

Target site includes receptor site, wherein, the skin pixels being cut open produce defect of skin at receptor site.

This method is included adhesiveness basal structure into capturing the multiple skin pixels being cut open at donor site And the multiple skin pixels being cut open are transferred to receptor site.

This method includes protecting adhesiveness basal structure into during being transferred to receptor site and applying at receptor site Hold the relative positioning of the multiple skin pixels being cut open.

This method include by adhesiveness basal structure into by the skin pixels being cut open be applied to receptor site at skin Defect.

This method includes the defect of skin at by the skin pixels being cut open and receptor site by adhesiveness basal structure Alignment.

This method includes adhesiveness basal structure being inserted at receptor site into by each skin pixels being cut open In corresponding defect of skin.

This method includes at least one bandage being configured in target location application.

This method includes at least one bandage being configured to applying power to close target site.

This method includes being configured to apply directional power in target site to control closure side by least one bandage To.

At least one bandage includes the first bandage, and the first bandage is configured for applying at donor site.

At least one bandage includes the second bandage, and the second bandage is configured for applying at receptor site.

This method includes skin graft knife system being configured to load transmission to the underlying skin surface for including target site, its In, skin pixels are cut open because of the application of load.

This method include by flap knife array structure into by load transmission to including the underlying skin surface of target site, its In, skin pixels are cut open because of the application of load.

This method includes skin graft knife system being constructed to rear disposable type.

This method include by skin graft knife system be configured to it is cleaned, sterilized and sterilized at least one Person.

This method is included structure of transvers plate into for being positioned at target site.

This method includes being configured to be aligned with template by skin graft knife system.

This method includes flap knife array structure being aligned into template.

Template is located on the skin surface of target site.

Template includes the indicant on the skin surface of target site.

Template includes guide plate, and guide plate is configured for being positioned at target site and including being set with a pattern Perforation.

Flap knife array is removably attached to skin graft knife system.

The rear disposable type of flap knife array.

The shape of each flap knife in flap knife array is ellipse.

The shape of each flap knife in flap knife array is circular.

The shape of each flap knife in flap knife array is semicircle.

The shape of each flap knife in flap knife array is square, rectangle and one of flat.

Each flap knife at least one flap knife includes inclined surface.

Each flap knife in the multiple flap knife includes at least one sharpened surface.

Each flap knife in the multiple flap knife includes at least one pin.

At least one pin includes multiple sophisticated pins including at least one.

This method includes producing flap knife array configuration into using at least one of force of piercing, impact and revolving force The raw skin pixels being cut open.

This method includes flap knife array configuration producing the skin pixels being cut open into using radio frequency (RF) energy.

This method includes flap knife array configuration producing the skin pixels being cut open into using vibrational energy.

At least one flap knife in flap knife array includes through hole.

At least one diameter dimension of each flap knife in flap knife array is approximately at 0.5 millimeter to 4.0 millimeters In the range of.

This method includes guide plate being configured for as Template Location in target site, wherein, guide plate includes The perforation set with a pattern.

This method includes flap knife array structure being aligned into the perforation in guide plate.

This method includes perforation of the flap knife array structure into via guide plate being applied to donor site, wherein, institute Multiple skin pixels are stated to be cut open.

This method includes flap knife array being applied to receptor site via the perforation in guide plate, wherein, generate more Individual defect of skin.

Target site includes donor site and receptor site.

The multiple skin pixels being cut open and the multiple defect of skin produce according to the pattern.

This method is included adhesiveness basal structure into capturing the multiple skin pixels being cut open at donor site And the multiple skin pixels being cut open are transferred to receptor site.

This method includes protecting adhesiveness basal structure into during being transferred to receptor site and applying at receptor site Hold the relative positioning of the multiple skin pixels being cut open.

This method is included flap knife array structure into directly through perforation and applied to donor site with by skin pixels Cut.

This method includes into directly through perforation lacking flap knife array structure to produce skin applied to receptor site Damage.

This method include by guide plate be configured to it is adhesiveness, rigid, semirigid, conformal, non-conformal and At least one of non-deformable.

This method includes being configured to guide plate to include at least one of metal, plastics, polymer and membrane material.

This method includes guide plate being configured at least one of load transmission to donor site and receptor site Skin surface.

This method includes being configured to be positioned directly on the skin surface of target site by guide plate.

This method includes being configured to extrude the multiple skin pixels being cut open by guide plate.

The multiple skin pixels are extruded in response to the load applied through perforation.

The multiple skin pixels are extruded in response to the load applied through the skin surface being cut open.

This method includes at least one of housing, skin graft knife system and flap knife array being configured for cutting structure Part is used together.

The skin pixels being cut open are crosscutting by cutting element.

This method includes the skin pixels for being cut open adhesiveness basal structure into capture.

This method includes cutting element being configured to couple to framework.

Framework is attached to guide plate, wherein, guide plate is configured to the guide member of skin graft knife system.

This method is included adhesiveness basal structure into being attached at least one of framework and guide plate.

The skin pixels being cut open include hair follicle.

This method is new in the skin pixels being cut open at promotion insertion receptor site including defect of skin is configured to Vascularization.

This method includes being configured to defect of skin to promote the wound in the skin pixels being cut open at insertion receptor site Mouth healing reaction.

Embodiment includes a kind of method, and this method includes being configured to housing to include skin graft knife system.This method includes Skin graft knife system is configured to include flap knife array, flap knife array includes the multiple flap knifes set with a pattern.It is described Multiple flap knifes are configured to deploy from housing and produce multiple skin pixels being cut open in target site.

Embodiment includes a kind of method, and this method includes：Housing is configured to include skin graft knife system；And by skin graft Knife system is configured to include flap knife array, and flap knife array includes the multiple flap knifes set with a pattern, wherein, it is described more Individual flap knife is configured to deploy from housing and produces multiple skin pixels being cut open in target site.

Embodiment includes a kind of method, and this method includes being configured to control device to include proximal end and distal end Portion.Proximal end includes actuator.This method includes being configured to include skin graft knife system and for can be removed by housing Mode is attached to the distal end of control device.This method includes being configured to skin graft knife system to include flap knife array, skin graft Knife array includes the multiple flap knifes set with a pattern.The multiple flap knife be configured to from housing deploy with upon deployment in Target site produces multiple skin pixels being cut open.

Embodiment includes a kind of method, and this method includes：Control device is configured to include proximal end and distal end Portion, wherein, proximal end includes actuator；Housing is configured to include skin graft knife system and for removably joining It is connected to the distal end of control device；And skin graft knife system is configured to include flap knife array, flap knife array include with Multiple flap knifes that one pattern is set, wherein, the multiple flap knife is configured to deploy with upon deployment in target portion from housing Multiple skin pixels being cut open are produced at position.

Unless the context clearly requires, otherwise throughout the specification, word " comprising ", " including " etc. are interpreted With exclusiveness or the adversative inclusive meaning of exhaustive；That is, it is construed to the meaning of " including but being not limited to " Justice.Equally include plural number or odd number respectively using the term of odd number and plural number.In addition, word " this paper ", " hereafter ", " more than ", " following " and the term of similar implication refer to as overall the application without referring to this Shen when used in this application Any specific part please.When using the word "or" for the list for being related to two or more items, the word is covered to this Word is carried out all explained below：Any combination of all items and the item in list in any one of list, list.

It is that the above description of embodiment is not intended to exhaustion or be not intended to system and method being limited to disclosed Precise forms.Although describe for the particular implementation of Medical Devices and method and show for purposes of illustration herein Example, it will be recognized to those skilled in the art that the various equivalent modifications in the range of system and method are all possible.Herein The Medical Devices of middle offer and the teaching of method can apply to other systems and method, and be used not only for said system and side Method.

The element of above-mentioned each embodiment and action can be combined to provide other embodiment.According to retouching in detail above State, can Medical Devices and method be made with these changes and other changes.

Generally, in the following claims, used term be not construed as Medical Devices and method and Corresponding system and method are limited to the particular implementation disclosed in description and claims, and should be interpreted to wrap Include all systems operated according to claim.Therefore, Medical Devices and method and corresponding system and method are not by open The limitation of content, alternatively, scope is determined by claim completely.

Although some aspects of Medical Devices and method and corresponding system and method are below with certain claim Form is presented, but inventor contemplate in the Medical Devices and method of arbitrary number claim formats and corresponding system and The each side of method.Therefore, inventor adds the right of accessory claim with regard to Medical Devices after being retained in submission the application With these additional additional claim forms in terms of other of method and corresponding system and method.

Claims (411)

1. a kind of equipment, including：

Housing, the housing are configured to include skin graft knife system；And

The skin graft knife system includes substrate and flap knife array, wherein, the flap knife array includes being arranged on a configuration Multiple flap knifes in the substrate, wherein, the substrate and the multiple flap knife be configured to from housing expansion and It is retracted in the housing, wherein, the multiple flap knife is configured to produce multiple be cut open in target site upon deployment Skin pixels.

2. equipment according to claim 1, wherein, the housing is configured to removably be attached to female part.

3. equipment according to claim 2, wherein, the female part is the part of control device.

4. equipment according to claim 3, wherein, the control device includes proximal end and distal end, wherein, institute Stating proximal end includes actuator mechanism, and the distal end includes the female part.

5. equipment according to claim 4, wherein, the flap knife array configuration is into response to the actuator mechanism Start and be unfolded.

6. equipment according to claim 4, wherein, the proximal end of the control device is constructed to hand-held 's.

7. equipment according to claim 4, wherein, the skin graft knife system is arranged so that the flap knife array response Deploy and be recovered in the skin graft knife system from the skin graft knife system in the startup of the actuator mechanism.

8. equipment according to claim 4, wherein, the skin graft knife system is arranged so that the flap knife array response Deploy in the startup of the actuator mechanism from the skin graft knife system.

9. equipment according to claim 8, wherein, the skin graft knife system is arranged so that the flap knife array response It is recovered in the release of the actuator mechanism in the skin graft knife system.

10. equipment according to claim 4, wherein, the control device is constructed to rear disposable type.

11. equipment according to claim 4, wherein, the control device is configured to cleaned, sterilized and warp At least one of sterilizing.

12. equipment according to claim 1, including adhesiveness substrate, the adhesiveness basal structure is described more into capturing The individual skin pixels being cut open.

13. equipment according to claim 12, wherein, the skin graft knife system is configured to include the adhesiveness substrate.

14. equipment according to claim 12, wherein, the housing is configured to include the adhesiveness substrate.

15. equipment according to claim 12, wherein, the adhesiveness substrate includes flex substrate.

16. equipment according to claim 12, wherein, the adhesiveness substrate includes semi-porous film.

17. equipment according to claim 1, including vacuum component.

18. equipment according to claim 17, wherein, the vacuum component is attached to the housing.

19. equipment according to claim 17, wherein, the vacuum component is attached to the skin graft knife system.

20. equipment according to claim 17, wherein, the vacuum component is attached to the flap knife via the housing Device.

21. equipment according to claim 17, wherein, the vacuum component is configured in the skin graft knife system and control Low-pressure area is produced at least one of device.

22. equipment according to claim 21, wherein, the low-pressure area is configured to the multiple skin picture being cut open Element is extracted out.

23. equipment according to claim 17, wherein, the housing is configured to removably be attached to control dress Put, wherein, the vacuum component is attached to the control device.

24. equipment according to claim 1, including radio frequency (RF) part.

25. equipment according to claim 24, wherein, the RF parts are configured to the skin graft knife system and the skin At least one of piece knife array provides heat energy.

26. equipment according to claim 24, wherein, the RF parts are configured to the skin graft knife system and the skin At least one of piece knife array provides vibrational energy.

27. equipment according to claim 24, wherein, the RF parts are configured to the skin graft knife system and the skin At least one of piece knife array, which provides, rotates energy.

28. equipment according to claim 24, wherein, the RF parts are configured to the skin graft knife system and the skin At least one of piece knife array provides acoustic energy.

29. equipment according to claim 24, wherein, the RF parts are attached to the housing.

30. equipment according to claim 24, wherein, the RF parts are attached to the skin graft knife system.

31. equipment according to claim 24, wherein, the RF parts are attached to the flap knife via the housing and filled Put.

32. equipment according to claim 24, wherein, the RF parts are attached to the flap knife array.

33. equipment according to claim 24, wherein, the RF parts are attached to the flap knife battle array via the housing Row.

34. equipment according to claim 24, wherein, the RF parts are attached at least one in the flap knife array Individual flap knife.

35. equipment according to claim 24, wherein, the RF parts are attached to the flap knife battle array via the housing At least one flap knife in row.

36. equipment according to claim 24, wherein, the housing is configured to removably be attached to control dress Put, wherein, the RF parts are attached to the control device.

37. equipment according to claim 1, including：

Vacuum component, the vacuum component are attached at least one of the skin graft knife system and described housing；And

Radio frequency (RF) part, the radio-frequency unit are attached in the skin graft knife system, the flap knife array and the housing At least one.

38. the equipment according to claim 37, wherein, the vacuum component is configured in the skin graft knife system and described Low-pressure area is produced at least one of housing.

39. the equipment according to claim 37, wherein, the RF parts are configured to the skin graft knife system, the skin At least one of piece knife array and the housing provide energy.

40. the equipment according to claim 39, wherein, the energy includes heat energy, vibrational energy, rotated in energy and acoustic energy At least one.

41. equipment according to claim 1, wherein, the target site includes receptor site, wherein, it is described to be cut open Skin pixels defect of skin is produced at the receptor site.

42. equipment according to claim 1, wherein, the target site includes donor site, wherein, in the donor Position obtains the multiple skin pixels being cut open.

43. equipment according to claim 42, wherein, the target site includes receptor site, wherein, it is described to be cut open Skin pixels defect of skin is produced at the receptor site.

44. equipment according to claim 43, including adhesiveness substrate, the adhesiveness basal structure is into the donor Position captures the multiple skin pixels being cut open and the multiple skin pixels being cut open is transferred into the acceptor Position.

45. equipment according to claim 44, wherein, the adhesiveness basal structure is cut open into by the multiple Skin pixels are transferred to the receptor site and keep the multiple skin being cut open during being applied at the receptor site The relative positioning of pixel.

46. equipment according to claim 44, wherein, the adhesiveness basal structure is into by the skin picture being cut open Element is applied to the defect of skin at the receptor site.

47. equipment according to claim 44, wherein, the adhesiveness basal structure is into by the skin picture being cut open The plain defect of skin with the receptor site is aligned.

48. equipment according to claim 47, wherein, the adhesiveness basal structure is into by each skin picture being cut open Element is inserted into the corresponding defect of skin at the receptor site.

49. equipment according to claim 43, including at least one bandage, at least one bandage is configured for The target site application.

50. equipment according to claim 49, wherein, at least one bandage is configured to applying power to close the mesh Mark position.

51. equipment according to claim 49, wherein, at least one bandage is configured to apply in the target site Add directive force to control closing direction.

52. equipment according to claim 51, wherein, at least one bandage includes the first bandage, and described first is taut Band is configured for applying at the donor site.

53. equipment according to claim 51, wherein, at least one bandage includes the second bandage, and described second is taut Band is configured for applying at the receptor site.

54. equipment according to claim 1, wherein, the skin graft knife system is configured to load transmission is described to including The underlying skin surface of target site, wherein, the skin pixels are cut open because of the application of the load.

55. equipment according to claim 1, wherein, the flap knife array structure is described into load transmission is extremely included The underlying skin surface of target site, wherein, the skin pixels are cut open because of the application of the load.

56. equipment according to claim 1, wherein, the skin graft knife system is constructed to rear disposable type.

57. equipment according to claim 1, wherein, the skin graft knife system be configured to it is cleaned, sterilized and At least one of sterilized.

58. equipment according to claim 1, including template, the structure of transvers plate is into for being positioned at the target site Place.

59. equipment according to claim 58, wherein, the skin graft knife system is configured to be aligned with the template.

60. equipment according to claim 58, wherein, the flap knife array structure is aligned into the template.

61. equipment according to claim 58, wherein, the template is located on the skin surface of the target site.

62. equipment according to claim 61, wherein, the template includes the skin positioned at the target site Indicant on surface.

63. equipment according to claim 61, wherein, the template includes guide plate, and the guide plate is configured for It is positioned at the target site and the perforation including being set with a pattern.

64. equipment according to claim 1, wherein, the flap knife array is removably attached to the skin Piece knife system.

65. equipment according to claim 1, wherein, the rear disposable type of the flap knife array.

66. equipment according to claim 1, wherein, the shape of each flap knife in the flap knife array is oval Shape.

67. equipment according to claim 1, wherein, the shape of each flap knife in the flap knife array is circular.

68. equipment according to claim 1, wherein, the shape of each flap knife in the flap knife array is semicircle Shape.

69. equipment according to claim 1, wherein, the shape of each flap knife in the flap knife array be it is square, Rectangle and one of flat.

70. equipment according to claim 1, wherein, each flap knife at least one flap knife includes nauropemeter Face.

71. equipment according to claim 1, wherein, each flap knife in the multiple flap knife includes at least one Individual sharpened surface.

72. equipment according to claim 1, wherein, each flap knife in the multiple flap knife includes at least one Individual pin.

73. the equipment according to claim 72, wherein, at least one pin includes at least one comprising multiple sophisticated Pin.

74. equipment according to claim 1, wherein, the flap knife array is utilized in force of piercing, impact and revolving force At least one produce the skin pixels being cut open.

75. equipment according to claim 1, wherein, the flap knife array is produced described using radio frequency (RF) energy The skin pixels being cut open.

76. equipment according to claim 1, wherein, the flap knife array produces described be cut open using vibrational energy Skin pixels.

77. equipment according to claim 1, wherein, at least one flap knife in the flap knife array includes through hole.

78. equipment according to claim 1, wherein, each flap knife in the flap knife array it is at least one straight Footpath size is approximately in the range of 0.5 millimeter to 4.0 millimeters.

79. equipment according to claim 1, including guide plate, the guide plate is configured for existing as Template Location The target site, wherein, the guide plate includes the perforation set with a pattern.

80. the equipment according to claim 79, wherein, the flap knife array structure into in the guide plate described in Perforation alignment.

81. the equipment according to claim 79, wherein, the flap knife array is via the perforation in the guide plate Applied to donor site, in the donor site, the multiple skin pixels are cut open.

82. the equipment according to claim 81, wherein, the flap knife array is via the perforation in the guide plate Applied to receptor site, in the receptor site, multiple defects of skin are generated.

83. the equipment according to claim 82, wherein, the target site includes the donor site and the acceptor portion Position.

84. the equipment according to claim 82, wherein, the multiple skin pixels being cut open and the multiple skin lack Damage produces according to the pattern.

85. the equipment according to claim 82, including adhesiveness substrate, the adhesiveness basal structure is into the donor Position captures the multiple skin pixels being cut open and the multiple skin pixels being cut open is transferred into the acceptor Position.

86. the equipment according to claim 85, wherein, the adhesiveness basal structure is cut open into by the multiple Skin pixels are transferred to the receptor site and keep the multiple skin being cut open during being applied at the receptor site The relative positioning of pixel.

87. the equipment according to claim 82, wherein, the flap knife array is applied to institute directly through the perforation State donor site and the skin pixels are cut open.

88. the equipment according to claim 82, wherein, the flap knife array is applied to institute directly through the perforation State receptor site and the defect of skin produces.

89. the equipment according to claim 79, wherein, the guide plate is adhesiveness, rigid, semirigid, suitable At least one of shape, non-conformal and non-deformable.

90. the equipment according to claim 79, wherein, the guide plate is included in metal, plastics, polymer and membrane material At least one.

91. the equipment according to claim 79, wherein, the guide plate is configured to load transmission to the donor site With the skin surface of at least one of the receptor site.

92. the equipment according to claim 79, wherein, the guide plate is positioned directly in the skin of the target site On surface.

93. the equipment according to claim 92, wherein, the guide plate is configured to the multiple skin picture being cut open Element extrusion.

94. the equipment according to claim 93, wherein, the multiple skin pixels pass through in response to the load applied The perforation is extruded.

95. the equipment according to claim 93, wherein, the multiple skin pixels pass through in response to the load applied The skin surface being cut open is extruded.

96. equipment according to claim 1, including cutting element.

97. the equipment according to claim 96, wherein, the skin pixels being cut open are crosscutting by the cutting element.

98. the equipment according to claim 97, including adhesiveness substrate, the adhesiveness basal structure is into capturing the quilt The skin pixels of incision.

99. the equipment according to claim 98, wherein, the cutting element is attached to framework.

100. the equipment according to claim 99, wherein, the framework is attached to guide plate, wherein, the guide plate structure Make as the guide member for the skin graft knife system.

101. the equipment according to claim 99, wherein, the adhesiveness substrate is attached to the framework and the guiding At least one of plate.

102. equipment according to claim 1, wherein, the skin pixels being cut open include hair follicle.

103. equipment according to claim 1, wherein, defect of skin is configured to promote the quilt at insertion receptor site Neovascularization in the skin pixels of incision.

104. equipment according to claim 1, wherein, defect of skin is configured to promote the quilt at insertion receptor site Wound healing reaction in the skin pixels of incision.

105. a kind of equipment, including：

Housing, the housing include skin graft knife system；And

The skin graft knife system includes flap knife array, and the flap knife array includes the multiple flap knifes set with a pattern, Wherein, the multiple flap knife can deploy from the housing to produce multiple skin pixels being cut open in target site.

106. a kind of system, including：

Control device, the control device include proximal end and distal end, wherein, the proximal end includes actuator machine Structure, and the distal end includes female part；And

Skin graft knife system, the skin graft knife system are configured to removably be attached to the receiving of the control device Part, wherein, the skin graft knife system includes substrate and flap knife array, and the flap knife array includes being arranged on institute with a configuration Multiple flap knifes in substrate are stated, wherein, the substrate and the multiple flap knife are configured to the actuator mechanism Startup and be unfolded, wherein, the multiple flap knife is configured to produce multiple be cut open in target site upon deployment Skin pixels.

107. the system according to claim 106, wherein, the proximal end of the control device is constructed to hold Formula.

108. the system according to claim 106, wherein, the target site includes receptor site, wherein, it is described to be cut The skin pixels opened produce defect of skin at the receptor site.

109. the system according to claim 106, wherein, the target site includes donor site, wherein, in the confession The multiple skin pixels being cut open are obtained at body region.

110. the system according to claim 109, wherein, the target site includes receptor site, wherein, it is described to be cut The skin pixels opened produce defect of skin at the receptor site.

111. the system according to claim 110, including adhesiveness substrate, the adhesiveness basal structure is into the confession Captured at body region the multiple skin pixels being cut open and by the multiple skin pixels being cut open be transferred to it is described by Body region.

112. the system according to claim 111, wherein, the adhesiveness basal structure is cut open into by the multiple Skin pixels be transferred to the receptor site and keep the multiple skin being cut open during applying at the receptor site The relative positioning of skin pixel.

113. the system according to claim 111, wherein, the adhesiveness basal structure is into by the skin being cut open Pixel is applied to the defect of skin at the receptor site.

114. the system according to claim 111, wherein, the adhesiveness basal structure is into by the skin being cut open Pixel is aligned with the defect of skin at the receptor site.

115. the system according to claim 114, wherein, the adhesiveness basal structure is into by each skin being cut open Pixel is inserted into the corresponding defect of skin at the receptor site.

116. the system according to claim 110, including at least one bandage, at least one bandage is configured for In the target site application.

117. the system according to claim 116, wherein, it is described to close that at least one bandage is configured to applying power Target site.

118. the system according to claim 116, wherein, at least one bandage is configured in the target site Power is applied directional to control closing direction.

119. the system according to claim 118, wherein, at least one bandage includes the first bandage, and described first Bandage is configured for applying at the donor site.

120. the system according to claim 118, wherein, at least one bandage includes the second bandage, and described second Bandage is configured for applying at the receptor site.

121. the system according to claim 106, including adhesiveness substrate, the adhesiveness basal structure is into described in capture Multiple skin pixels being cut open.

122. the system according to claim 121, wherein, the skin graft knife system is configured to include the adhesiveness base Bottom.

123. the system according to claim 121, wherein, the adhesiveness substrate includes flex substrate.

124. the system according to claim 121, wherein, the adhesiveness substrate includes semi-porous film.

125. the system according to claim 106, wherein, the skin graft knife system is arranged so that the flap knife array Deploy and be recovered in the skin graft knife system from the skin graft knife system in response to the startup of the actuator mechanism.

126. the system according to claim 106, wherein, the skin graft knife system is arranged so that the flap knife array Deploy in response to the startup of the actuator mechanism from the skin graft knife system.

127. the system according to claim 126, wherein, the skin graft knife system is arranged so that the flap knife array It is recovered in response to the release of the actuator mechanism in the skin graft knife system.

128. the system according to claim 106, wherein, the skin graft knife system is configured to load transmission extremely including institute The underlying skin surface of target site is stated, wherein, the skin pixels are cut open because of the application of the load.

129. the system according to claim 106, wherein, the flap knife array structure extremely includes institute into by load transmission The underlying skin surface of target site is stated, wherein, the skin pixels are cut open because of the application of the load.

130. the system according to claim 106, wherein, the skin graft knife system is constructed to rear disposable type.

131. the system according to claim 106, wherein, the skin graft knife system is configured to cleaned, sterilized And it is at least one of sterilized.

132. the system according to claim 106, wherein, the control device is constructed to rear disposable type.

133. the system according to claim 106, wherein, the control device is configured to cleaned, sterilized With it is at least one of sterilized.

134. the system according to claim 106, including template, the structure of transvers plate is into for being positioned at the target portion At position.

135. the system according to claim 134, wherein, the skin graft knife system is configured to be aligned with the template.

136. the system according to claim 134, wherein, the flap knife array structure is aligned into the template.

137. the system according to claim 134, wherein, the template is located at the skin surface of the target site On.

138. the system according to claim 137, wherein, the template includes the skin positioned at the target site Indicant on skin surface.

139. the system according to claim 137, wherein, the template includes guide plate, and the guide plate is configured to use In being positioned at the target site and the perforation including being set with a pattern.

140. the system according to claim 106, wherein, the flap knife array is removably attached to described Skin graft knife system.

141. system according to claim 106, wherein, the rear disposable type of the flap knife array.

142. system according to claim 106, wherein, the shape of each flap knife in the flap knife array is ellipse It is circular.

143. system according to claim 106, wherein, the shape of each flap knife in the flap knife array is round Shape.

144. system according to claim 106, wherein, the shape of each flap knife in the flap knife array is half It is circular.

145. system according to claim 106, wherein, the shape side of being of each flap knife in the flap knife array Shape, rectangle and one of flat.

146. system according to claim 106, wherein, each flap knife at least one flap knife includes tilting Surface.

147. system according to claim 106, wherein, each flap knife in the multiple flap knife is included at least One sharpened surface.

148. system according to claim 106, wherein, each flap knife in the multiple flap knife is included at least One pin.

149. system according to claim 148, wherein, at least one pin includes multiple tips including at least one Pin.

150. system according to claim 106, wherein, the flap knife array utilizes force of piercing, impact and rotation At least one of power produces the skin pixels being cut open.

151. system according to claim 106, wherein, the flap knife array is using radio frequency (RF) energy to produce State the skin pixels being cut open.

152. system according to claim 106, wherein, the flap knife array produces described cut using vibrational energy The skin pixels opened.

153. system according to claim 106, wherein, at least one flap knife in the flap knife array includes logical Hole.

154. system according to claim 106, wherein, each flap knife in the flap knife array it is at least one Diameter dimension is approximately in the range of 0.5 millimeter to 4.0 millimeters.

155. system according to claim 106, including vacuum component.

156. system according to claim 155, wherein, the vacuum component is attached to the control device.

157. system according to claim 155, wherein, the vacuum component is attached to the skin graft knife system.

158. system according to claim 155, wherein, the vacuum component is attached to described via the control device Skin graft knife system.

159. system according to claim 155, wherein, the vacuum component is configured in the skin graft knife system and institute State and low-pressure area is produced at least one of control device.

160. system according to claim 159, wherein, the low-pressure area is configured to the multiple skin being cut open Pixel is extracted out.

161. system according to claim 106, including radio frequency (RF) part.

162. system according to claim 161, wherein, the RF parts are configured to the skin graft knife system, described At least one of flap knife array and the control device provide heat energy.

163. system according to claim 161, wherein, the RF parts are configured to the skin graft knife system, described At least one of flap knife array and the control device provide vibrational energy.

164. system according to claim 161, wherein, the RF parts are configured to the skin graft knife system, described At least one of flap knife array and the control device, which provide, rotates energy.

165. system according to claim 161, wherein, the RF parts are configured to the skin graft knife system, described At least one of flap knife array and the control device provide acoustic energy.

166. system according to claim 161, wherein, the RF parts are attached to the control device.

167. system according to claim 161, wherein, the RF parts are attached to the skin graft knife system.

168. system according to claim 161, wherein, the RF parts are attached to the skin via the control device Piece knife system.

169. system according to claim 161, wherein, the RF parts are attached to the flap knife array.

170. system according to claim 161, wherein, the RF parts are attached to the skin via the control device Piece knife array.

171. system according to claim 161, wherein, the RF parts are attached in the flap knife array at least One flap knife.

172. system according to claim 161, wherein, the RF parts are attached to the skin via the control device At least one flap knife in piece knife array.

173. system according to claim 106, including：

Vacuum component, the vacuum component are attached at least one of the skin graft knife system and described control device；And

Radio frequency (RF) part, the radio-frequency unit are attached to the skin graft knife system, the flap knife array and the control dress At least one of put.

174. system according to claim 173, wherein, the vacuum component is configured in the skin graft knife system and institute State and low-pressure area is produced at least one of control device.

175. system according to claim 173, wherein, the RF parts are configured to the skin graft knife system, described At least one of flap knife array and the control device provide energy.

176. system according to claim 175, wherein, the energy includes heat energy, vibrational energy, rotated in energy and acoustic energy At least one.

177. system according to claim 106, including guide plate, the guide plate are configured for as Template Location In the target site, wherein, the guide plate includes the perforation set with a pattern.

178. system according to claim 177, wherein, the flap knife array structure into the institute in the guide plate State perforation alignment.

179. system according to claim 177, wherein, the flap knife array is worn via described in the guide plate Hole is applied to donor site, and in the donor site, the multiple skin pixels are cut open.

180. system according to claim 179, wherein, the flap knife array is worn via described in the guide plate Hole is applied to receptor site, and in the receptor site, the multiple defect of skin produces.

181. system according to claim 180, wherein, the target site includes the donor site and the acceptor Position.

182. system according to claim 180, wherein, the multiple skin pixels being cut open and the multiple skin Defect produces according to the pattern.

183. system according to claim 180, including adhesiveness substrate, the adhesiveness basal structure is into the confession Captured at body region the multiple skin pixels being cut open and by the multiple skin pixels being cut open be transferred to it is described by Body region.

184. system according to claim 183, wherein, the adhesiveness basal structure is cut open into by the multiple Skin pixels be transferred to the receptor site and keep the multiple skin being cut open during applying at the receptor site The relative positioning of skin pixel.

185. system according to claim 180, wherein, the flap knife array is applied to directly through the perforation The donor site and skin pixels are cut open.

186. system according to claim 180, wherein, the flap knife array is applied to directly through the perforation The receptor site and defect of skin generation.

187. system according to claim 177, wherein, the guide plate be adhesiveness, it is rigid, semirigid, At least one of conformal, non-conformal and non-deformable.

188. system according to claim 177, wherein, the guide plate includes metal, plastics, polymer and membrane material At least one of.

189. system according to claim 177, wherein, the guide plate is configured to load transmission to the donor portion The skin surface of position and at least one of the receptor site.

190. system according to claim 177, wherein, the guide plate is positioned directly in the skin of the target site On skin surface.

191. system according to claim 190, wherein, the guide plate is configured to the multiple skin being cut open Pixel is extruded.

192. system according to claim 191, wherein, the multiple skin pixels are worn in response to the load applied The perforation is crossed to be extruded.

193. system according to claim 191, wherein, the multiple skin pixels are worn in response to the load applied The skin surface being cut open is crossed to be extruded.

194. system according to claim 106, including cutting element.

195. system according to claim 194, wherein, the skin pixels being cut open are horizontal by the cutting element Cut.

196. system according to claim 195, including adhesiveness substrate, the adhesiveness basal structure is into described in capture The skin pixels being cut open.

197. system according to claim 196, wherein, the cutting element is attached to framework.

198. system according to claim 197, wherein, the framework is attached to guide plate, wherein, the guide plate structure Make as the guide member for the skin graft knife system.

199. system according to claim 197, wherein, the adhesiveness substrate is attached to the framework and the guiding At least one of plate.

200. system according to claim 106, wherein, the skin pixels being cut open include hair follicle.

201. system according to claim 106, wherein, defect of skin is configured to described at promotion insertion receptor site Neovascularization in the skin pixels being cut open.

202. system according to claim 106, wherein, defect of skin is configured to promote the quilt of insertion receptor site Wound healing reaction in the skin pixels of incision.

A kind of 203. systems, including：

Control device；And

Skin graft knife system, the skin graft knife system are removably attached to the control device, wherein, the flap knife Device includes flap knife array, and the flap knife array includes the multiple flap knifes set with a pattern, wherein, the multiple skin Piece knife is configured to be deployed by the startup that the control device is carried out and shunk and produced in target site multiple The skin pixels being cut open.

A kind of 204. systems, including：

Control device, the control device include actuator mechanism；And

Skin graft knife system, the skin graft knife system are configured to removably be attached to the control device, wherein, it is described Skin graft knife system includes substrate and flap knife array, and the flap knife array includes setting on the substrate more with a pattern Individual flap knife, wherein, the substrate and the multiple flap knife are configured to the startup of the actuator mechanism and carried out At least one of expansion and contraction, wherein, the multiple flap knife is configured to multiple in target site generation upon deployment The skin pixels being cut open.

A kind of 205. systems, including：

Housing, the housing are configured to include skin graft knife system；

The skin graft knife system includes substrate and flap knife array, wherein, the flap knife array includes being arranged on a configuration Multiple flap knifes in the substrate, wherein, the substrate and the multiple flap knife be configured to from housing expansion and It is retracted in the housing, wherein, the multiple flap knife is configured to produce multiple be cut open in target site upon deployment Skin pixels；And

Vacuum component, the vacuum component are configured to the neighbouring skin graft knife system and produce low-pressure area.

206. system according to claim 205, wherein, the vacuum component is attached to the housing.

207. system according to claim 205, wherein, the vacuum component is attached to the skin graft knife system.

208. system according to claim 205, wherein, the vacuum component is attached to the skin graft via the housing Knife system.

209. system according to claim 205, wherein, the vacuum component is configured in the housing described in generation Low-pressure area.

210. system according to claim 205, wherein, the low-pressure area is configured to the multiple skin being cut open Pixel is extracted out.

211. system according to claim 205, wherein, the housing is configured to removably be attached to receiving Part.

212. system according to claim 211, wherein, the female part is the part of control device.

213. system according to claim 212, wherein, the control device includes proximal end and distal end, its In, the proximal end includes actuator mechanism, and the distal end includes the female part.

214. system according to claim 213, wherein, the flap knife array configuration is into response to the actuator machine The startup of structure and be unfolded.

215. system according to claim 213, wherein, the proximal end of the control device is constructed to hold Formula.

216. system according to claim 213, wherein, the skin graft knife system is arranged so that the flap knife array Deploy and be recovered in the skin graft knife system from the skin graft knife system in response to the startup of the actuator mechanism.

217. system according to claim 213, wherein, the skin graft knife system is arranged so that the flap knife array Deploy in response to the startup of the actuator mechanism from the skin graft knife system.

218. system according to claim 217, wherein, the skin graft knife system is arranged so that the flap knife array It is recovered in response to the release of the actuator mechanism in the skin graft knife system.

219. system according to claim 213, wherein, the control device is constructed to rear disposable type.

220. system according to claim 213, wherein, the control device is configured to cleaned, sterilized With it is at least one of sterilized.

221. system according to claim 205, including adhesiveness substrate, the adhesiveness basal structure is into described in capture Multiple skin pixels being cut open.

222. system according to claim 221, wherein, the skin graft knife system is configured to include the adhesiveness base Bottom.

223. system according to claim 221, wherein, the housing is configured to include the adhesiveness substrate.

224. system according to claim 221, wherein, the adhesiveness substrate includes flex substrate.

225. system according to claim 221, wherein, the adhesiveness substrate includes semi-porous film.

226. system according to claim 205, including radio frequency (RF) part.

227. system according to claim 226, wherein, the RF parts are configured to the skin graft knife system and described At least one of flap knife array provides heat energy.

228. system according to claim 226, wherein, the RF parts are configured to the skin graft knife system and described At least one of flap knife array provides vibrational energy.

229. the system according to claim 226, wherein, the RF parts are configured to the skin graft knife system and described At least one of flap knife array, which provides, rotates energy.

230. system according to claim 226, wherein, the RF parts are configured to the skin graft knife system and described At least one of flap knife array provides acoustic energy.

231. system according to claim 226, wherein, the RF parts are attached to the housing.

232. system according to claim 226, wherein, the RF parts are attached to the skin graft knife system.

233. the system according to claim 226, wherein, the RF parts are attached to the flap knife via the housing Device.

234. system according to claim 226, wherein, the RF parts are attached to the flap knife array.

235. system according to claim 226, wherein, the RF parts are attached to the flap knife via the housing Array.

236. system according to claim 226, wherein, the RF parts are attached in the flap knife array at least One flap knife.

237. system according to claim 226, wherein, the RF parts are attached to the flap knife via the housing At least one flap knife in array.

238. system according to claim 226, wherein, the housing is configured to removably be attached to control Device, wherein, the RF parts are attached to the control device.

239. system according to claim 205, wherein, the target site includes receptor site, wherein, it is described to be cut The skin pixels opened produce defect of skin at the receptor site.

240. system according to claim 205, wherein, the target site includes donor site, wherein, in the confession The multiple skin pixels being cut open are obtained at body region.

241. system according to claim 240, wherein, the target site includes receptor site, wherein, it is described to be cut The skin pixels opened produce defect of skin at the receptor site.

242. system according to claim 241, including adhesiveness substrate, the adhesiveness basal structure is into the confession Captured at body region the multiple skin pixels being cut open and by the multiple skin pixels being cut open be transferred to it is described by Body region.

243. system according to claim 242, wherein, the adhesiveness basal structure is cut open into by the multiple Skin pixels be transferred to the receptor site and keep the multiple skin being cut open during applying at the receptor site The relative positioning of skin pixel.

244. system according to claim 242, wherein, the adhesiveness basal structure is into the skin pixels that will be cut open Applied to the defect of skin at the receptor site.

245. system according to claim 242, wherein, the adhesiveness basal structure is into by the skin being cut open Pixel is aligned with the defect of skin at the receptor site.

246. system according to claim 245, wherein, the adhesiveness basal structure is into by each skin being cut open Pixel is inserted into the corresponding defect of skin at the receptor site.

247. system according to claim 241, including at least one bandage, at least one bandage are configured for In the target site application.

248. system according to claim 247, wherein, it is described to close that at least one bandage is configured to applying power Target site.

249. system according to claim 247, wherein, at least one bandage is configured in the target site Power is applied directional to control closing direction.

250. system according to claim 249, wherein, at least one bandage includes the first bandage, and described first Bandage is configured to apply at the donor site.

251. system according to claim 249, wherein, at least one bandage includes the second bandage, and described second Bandage is configured for applying at the receptor site.

252. system according to claim 205, wherein, the skin graft knife system is configured to load transmission extremely including institute The underlying skin surface of target site is stated, wherein, the skin pixels are cut open because of the application of the load.

253. system according to claim 205, wherein, the flap knife array structure extremely includes institute into by load transmission The underlying skin surface of target site is stated, wherein, the skin pixels are cut open because of the application of the load.

254. system according to claim 205, wherein, the skin graft knife system is constructed to rear disposable type.

255. system according to claim 205, wherein, the skin graft knife system is configured to cleaned, sterilized And it is at least one of sterilized.

256. system according to claim 205, including template, the structure of transvers plate is into for being positioned at the target portion At position.

257. system according to claim 256, wherein, the skin graft knife system is configured to be aligned with the template.

258. system according to claim 256, wherein, the flap knife array structure is aligned into the template.

259. system according to claim 256, wherein, the template is located at the skin surface of the target site On.

260. system according to claim 259, wherein, the template includes the skin positioned at the target site Indicant on skin surface.

261. system according to claim 259, wherein, the template includes guide plate, and the guide plate is configured to use In being positioned at the target site and the perforation including being set with a pattern.

262. system according to claim 205, wherein, the flap knife array is removably attached to described Skin graft knife system.

263. system according to claim 205, wherein, the rear disposable type of the flap knife array.

264. system according to claim 205, wherein, the shape of each flap knife in the flap knife array is ellipse It is circular.

265. system according to claim 205, wherein, the shape of each flap knife in the flap knife array is round Shape.

266. system according to claim 205, wherein, the shape of each flap knife in the flap knife array is half It is circular.

267. system according to claim 205, wherein, the shape side of being of each flap knife in the flap knife array Shape, rectangle and one of flat.

268. system according to claim 205, wherein, each flap knife at least one flap knife includes tilting Surface.

269. system according to claim 205, wherein, each flap knife in the multiple flap knife is included at least One sharpened surface.

270. system according to claim 205, wherein, each flap knife in the multiple flap knife is included at least One pin.

271. system according to claim 270, wherein, at least one pin includes multiple tips including at least one Pin.

272. system according to claim 205, wherein, the flap knife array utilizes force of piercing, impact and rotation At least one of power produces the skin pixels being cut open.

273. system according to claim 205, wherein, the flap knife array is using radio frequency (RF) energy to produce State the skin pixels being cut open.

274. system according to claim 205, wherein, the flap knife array produces described cut using vibrational energy The skin pixels opened.

275. system according to claim 205, wherein, at least one flap knife in the flap knife array includes logical Hole.

276. system according to claim 205, wherein, each flap knife in the flap knife array it is at least one Diameter dimension is approximately in the range of 0.5 millimeter to 4.0 millimeters.

277. system according to claim 205, including guide plate, the guide plate are configured as Template Location in institute Target site is stated, wherein, the guide plate includes the perforation set with a pattern.

278. system according to claim 277, wherein, the flap knife array structure into the institute in the guide plate State perforation alignment.

279. system according to claim 277, wherein, the flap knife array is worn via described in the guide plate Hole is applied to donor site, and in the donor site, the multiple skin pixels are cut open.

280. system according to claim 279, wherein, the flap knife array is worn via described in the guide plate Hole is applied to receptor site, in the receptor site, generates multiple defects of skin.

281. system according to claim 280, wherein, the target site includes the donor site and the acceptor Position.

282. system according to claim 280, wherein, the multiple skin pixels being cut open and the multiple skin Defect produces according to the pattern.

283. system according to claim 280, including adhesiveness substrate, the adhesiveness basal structure is into the confession Captured at body region the multiple skin pixels being cut open and by the multiple skin pixels being cut open be transferred to it is described by Body region.

284. system according to claim 283, wherein, the adhesiveness basal structure is cut open into by the multiple Skin pixels be transferred to the receptor site and keep the multiple skin being cut open during applying at the receptor site The relative positioning of skin pixel.

285. system according to claim 280, wherein, the flap knife array is applied to directly through the perforation The donor site and skin pixels are cut open.

286. system according to claim 280, wherein, the flap knife array is applied to directly through the perforation The receptor site and defect of skin generation.

287. system according to claim 277, wherein, the guide plate be adhesiveness, it is rigid, semirigid, At least one of conformal, non-conformal and non-deformable.

288. system according to claim 277, wherein, the guide plate includes metal, plastics, polymer and membrane material At least one of.

289. system according to claim 277, wherein, the guide plate is configured to load transmission to the donor portion The skin surface of position and at least one of the receptor site.

290. system according to claim 277, wherein, the guide plate is positioned directly in the skin of the target site On skin surface.

291. system according to claim 290, wherein, the guide plate is configured to the multiple skin being cut open Pixel is extruded.

292. system according to claim 291, wherein, the multiple skin pixels are worn in response to the load applied The perforation is crossed to be extruded.

293. the system according to claim 291, wherein, the multiple skin pixels are worn in response to the load applied The skin surface being cut open is crossed to be extruded.

294. system according to claim 205, including cutting element.

295. system according to claim 294, wherein, the skin pixels being cut open are horizontal by the cutting element Cut.

296. system according to claim 295, including adhesiveness substrate, the adhesiveness basal structure is into described in capture The skin pixels being cut open.

297. system according to claim 296, wherein, the cutting element is attached to framework.

298. system according to claim 297, wherein, the framework is attached to guide plate, wherein, the guide plate structure Make as the guide member for the skin graft knife system.

299. system according to claim 297, wherein, the adhesiveness substrate is attached to the framework and the guiding At least one of plate.

300. system according to claim 205, wherein, the skin pixels being cut open include hair follicle.

301. system according to claim 205, wherein, the defect of skin is configured to promote to insert the receptor site Neovascularization in the skin pixels being cut open at place.

302. system according to claim 205, wherein, the defect of skin is configured to promote to insert the receptor site Wound healing reaction in the skin pixels being cut open at place.

A kind of 303. systems, including：

Housing, the housing include skin graft knife system；And

The skin graft knife system includes flap knife array, and the flap knife array includes the multiple flap knifes set with a pattern, Wherein, the multiple flap knife can deploy from the housing to produce multiple skin pixels being cut open in target site； And

Vacuum component, the vacuum component are configured to the neighbouring skin graft knife system and produce low-pressure area.

A kind of 304. methods, including：

Housing including skin graft knife system is positioned at target site, wherein, the skin graft knife system includes substrate and skin graft Knife array, wherein, the flap knife array includes multiple flap knifes with configuration setting on the substrate；

The flap knife array is set to be deployed into from the housing in the tissue of the target site and in the target site Place produces multiple skin pixels being cut open；And

The flap knife array is set to be retracted to from the target site in the housing.

305. method according to claim 304, including the housing is attached to female part, the female part is control The part of device.

306. method according to claim 305, wherein, the control device includes proximal end and distal end, its In, the proximal end includes actuator mechanism, and the distal end includes the female part.

307. method according to claim 306, wherein, the expansion includes making the flap knife array response in described The startup of actuator mechanism and deploy.

308. method according to claim 306, wherein, described shrink includes making the flap knife array response in described The startup of actuator mechanism and shrink.

309. method according to claim 306, wherein, described shrink includes making the flap knife array response in described The release of actuator mechanism and shrink.

310. method according to claim 306, wherein, the proximal end of the control device is constructed to hold Formula.

311. method according to claim 306, including the skin graft knife system is disconnected with the female part and couple simultaneously And the skin graft knife system is abandoned.

312. method according to claim 306, including during the control device is cleaned, sterilized and sterilized extremely Few one.

313. method according to claim 304, the multiple skin being cut open is captured including the use of adhesiveness substrate Skin pixel.

314. method according to claim 313, wherein, the skin graft knife system includes the adhesiveness substrate.

315. method according to claim 313, wherein, the housing includes the adhesiveness substrate.

316. method according to claim 313, wherein, the adhesiveness substrate includes flex substrate.

Method described in 317. claims 313, wherein, the adhesiveness substrate includes semi-porous film.

318. method according to claim 304, including obtain the multiple skin pixels being cut open.

319. method according to claim 318, wherein, described obtain is included the multiple skin pixels being cut open Extract out.

320. method according to claim 318, wherein, the acquisition is included in the skin graft knife system and the housing At least one of in produce low-pressure area.

321. method according to claim 320, wherein, the low-pressure area is produced including the use of vacuum component.

322. method according to claim 321, wherein, the vacuum component is attached to the housing.

323. method according to claim 321, wherein, the vacuum component is attached to the skin graft knife system.

324. method according to claim 321, wherein, the vacuum component is attached to the skin graft via the housing Knife system.

325. method according to claim 321, wherein, the housing is configured to removably be attached to control Device, wherein, the vacuum component is attached to the control device.

326. method according to claim 304, wherein, producing the multiple skin pixels being cut open is included to described At least one of skin graft knife system, the flap knife array and described housing provide energy.

327. method according to claim 304, wherein, the offer energy is including the use of radio frequency (RF) part.

328. method according to claim 327, wherein, the energy includes heat energy, vibrational energy, rotated in energy and acoustic energy At least one.

329. method according to claim 327, wherein, the offer energy is included to the skin graft knife system and described At least one of flap knife array provides heat energy.

330. method according to claim 327, wherein, the offer energy is included to the skin graft knife system and described At least one of flap knife array provides vibrational energy.

331. method according to claim 327, wherein, the offer energy is included to the skin graft knife system and described At least one of flap knife array, which provides, rotates energy.

332. method according to claim 327, wherein, the offer energy is included to the skin graft knife system and described At least one of flap knife array provides acoustic energy.

333. method according to claim 327, wherein, the RF parts are attached to the housing.

334. method according to claim 327, wherein, the RF parts are attached to the skin graft knife system.

335. method according to claim 327, wherein, the RF parts are attached to the flap knife via the housing Device.

336. method according to claim 327, wherein, the RF parts are attached to the flap knife array.

337. method according to claim 327, wherein, the RF parts are attached to the flap knife via the housing Array.

338. method according to claim 327, wherein, the RF parts are attached in the flap knife array at least One flap knife.

339. method according to claim 327, wherein, the RF parts are attached to the flap knife via the housing At least one flap knife in array.

340. method according to claim 327, wherein, the housing is configured to removably be attached to control Device, wherein, the RF parts are attached to the control device.

341. method according to claim 304, the multiple skin being cut open is obtained including the use of vacuum component Pixel, wherein, the multiple skin pixels being cut open are produced using radio frequency (RF) energy.

342. method according to claim 341, wherein, the vacuum component is configured in the skin graft knife system and institute State and low-pressure area is produced at least one of housing.

343. method according to claim 341, wherein, the RF parts are configured to the skin graft knife system, described At least one of flap knife array and the housing provide energy.

344. method according to claim 343, wherein, the energy includes heat energy, vibrational energy, rotated in energy and acoustic energy At least one.

345. method according to claim 304, wherein, the target site includes receptor site, wherein, it is described to be cut The skin pixels opened produce defect of skin at the receptor site.

346. method according to claim 304, wherein, the target site includes donor site, wherein, in the confession The multiple skin pixels being cut open are obtained at body region.

347. method according to claim 346, wherein, the target site includes receptor site, wherein, it is described to be cut The skin pixels opened produce defect of skin at the receptor site.

348. method according to claim 347, the multiple skin being cut open is captured including the use of adhesiveness substrate Skin pixel and the multiple skin pixels being cut open are transferred to the receptor site.

349. method according to claim 348, including the adhesiveness substrate is by multiple skin pixels being cut open The relative positioning of the multiple skin pixels being cut open is kept during being transferred to the receptor site.

350. method according to claim 348, including the multiple from the adhesiveness substrate is cut open Skin pixels are applied to the defect of skin at the receptor site.

351. method according to claim 348, it is cut open including the use of the adhesiveness substrate by the multiple Skin pixels are aligned with the defect of skin at the receptor site.

352. method according to claim 351, including by the skin being each cut open from the adhesiveness substrate Pixel is inserted into the corresponding defect of skin at the receptor site.

353. method according to claim 347, it is included in the target site and applies at least one bandage.

354. method according to claim 353, wherein, include applying power using at least one bandage to close State target site.

355. method according to claim 353, wherein, it is included in the target site using at least one bandage Place applies directional power to control closing direction.

356. method according to claim 355, wherein, it is included in the donor site using at least one bandage Apply the first bandage in place.

357. method according to claim 355, wherein, it is included in the receptor site using at least one bandage Apply the second bandage in place.

358. method according to claim 304, wherein, producing the multiple skin pixels being cut open is included load The underlying skin surface including the target site is transferred to via the skin graft knife system, wherein, by applying the load And the skin pixels are cut.

359. method according to claim 304, wherein, producing the multiple skin pixels being cut open is included load The underlying skin surface including the target site is transferred to via the flap knife array, wherein, by applying the load And the skin pixels are cut.

360. method according to claim 304, wherein, the skin graft knife system is constructed to rear disposable type.

361. method according to claim 304, wherein, the skin graft knife system is configured to cleaned, sterilized And it is at least one of sterilized.

362. method according to claim 304, including by Template Location in the target site.

363. method according to claim 362, including the skin graft knife system is aligned with the template.

364. method according to claim 362, including the flap knife array is aligned with the template.

365. method according to claim 362, wherein, the positioning is included the Template Location in the target portion On skin surface at position.

366. method according to claim 365, wherein, the template includes the skin positioned at the target site Indicant on skin surface.

367. method according to claim 365, wherein, the template includes guide plate, and the guide plate is configured to use In being positioned at the target site and the perforation including being set with a pattern.

368. method according to claim 304, including the flap knife array is removably attached to institute State skin graft knife system.

369. method according to claim 304, wherein, the rear disposable type of the flap knife array.

370. method according to claim 304, wherein, the shape of each flap knife in the flap knife array is ellipse It is circular.

371. method according to claim 304, wherein, the shape of each flap knife in the flap knife array is round Shape.

372. method according to claim 304, wherein, the shape of each flap knife in the flap knife array is half It is circular.

373. method according to claim 304, wherein, the shape side of being of each flap knife in the flap knife array Shape, rectangle and one of flat.

374. method according to claim 304, wherein, each flap knife in the multiple flap knife includes tilting Surface.

375. the method according to claim 304, wherein, each flap knife in the multiple flap knife is included at least One sharpened surface.

376. method according to claim 304, wherein, each flap knife in the multiple flap knife is included at least One pin.

377. method according to claim 376, wherein, at least one pin includes multiple tips including at least one Pin.

378. method according to claim 304, wherein, the multiple pixel being cut open is produced using puncture At least one of power, impact and revolving force produce.

379. method according to claim 304, wherein, the multiple pixel being cut open is produced using radio frequency (RF) energy produces.

380. method according to claim 304, wherein, the multiple pixel being cut open is produced using vibrational energy To produce.

381. method according to claim 304, wherein, at least one flap knife in the flap knife array includes logical Hole.

382. method according to claim 304, wherein, each flap knife in the flap knife array it is at least one Diameter dimension is approximately in the range of 0.5 millimeter to 4.0 millimeters.

383. method according to claim 304, including using guide plate as Template Location in the target site, its In, the guide plate includes the perforation set with a pattern.

384. method according to claim 383, including by the flap knife array with the guide plate described in wear Hole is aligned.

385. method according to claim 383, including by the flap knife array via described in the guide plate Perforation is applied to donor site, and in the donor site, the multiple skin pixels are cut open.

386. method according to claim 385, including by the flap knife array via described in the guide plate Perforation is applied to receptor site, in the receptor site, generates multiple defects of skin.

387. method according to claim 386, wherein, the target site includes the donor site and the acceptor Position.

388. method according to claim 386, including the multiple skin being cut open is produced according to the pattern Pixel and the multiple defect of skin.

389. method according to claim 386, come to capture institute at the donor site using adhesiveness substrate State multiple skin pixels being cut open and the multiple skin pixels being cut open are transferred to the receptor site.

390. method according to claim 389, be included in the multiple skin pixels being cut open are transferred to it is described Receptor site and the adhesiveness substrate is utilized to keep the multiple skin being cut open during applying at the receptor site The relative positioning of pixel.

391. method according to claim 386, including the flap knife array is applied directly through the perforation Cut in the donor site and by the skin pixels.

392. method according to claim 391, including the flap knife array is applied directly through the perforation Produced in the receptor site and the defect of skin.

393. method according to claim 383, wherein, the guide plate be adhesiveness, it is rigid, semirigid, At least one of conformal, non-conformal and non-deformable.

394. method according to claim 383, wherein, the guide plate includes metal, plastics, polymer and membrane material At least one of.

395. method according to claim 383, wherein, the guide plate is configured to load transmission to the donor portion The skin surface of position and at least one of the receptor site.

396. method according to claim 383, including the guide plate is positioned directly in the target site On skin surface.

397. method according to claim 396, including the use of the guide plate by the multiple skin picture being cut open Element extrusion.

398. method according to claim 397, including the load in response to being applied and by the multiple skin pixels Through the perforation extrusion.

399. method according to claim 397, including the load in response to being applied and by the multiple skin pixels Through the skin surface extrusion being cut open.

400. method according to claim 304, wherein, the multiple skin pixels being cut open are produced using cutting Component is cut to cut.

401. method according to claim 400, using the cutting element to the skin pixels being cut open Carry out crosscutting.

402. method according to claim 401, the skin picture being cut open is captured using adhesiveness substrate Element.

403. method according to claim 402, wherein, the cutting element is attached to framework.

404. method according to claim 403, wherein, the framework is attached to guide plate, wherein, the guide plate structure Make as the guide member for the skin graft knife system.

405. method according to claim 403, wherein, the adhesiveness substrate is attached to the framework and the guiding At least one of plate.

406. method according to claim 304, wherein, the skin pixels being cut open include hair follicle.

407. method according to claim 304, including the use of defect of skin come promote insert receptor site at described in Neovascularization in the skin pixels being cut open.

408. method according to claim 304, promote the institute of insertion receptor site including the use of the defect of skin State the wound healing reaction in the skin pixels being cut open.

A kind of 409. methods, including：

Formed and coupled between control device and skin graft knife system, wherein, the control device includes actuator, wherein, it is described Skin graft knife system includes flap knife array, and the flap knife array includes the multiple flap knifes set with a pattern；

The skin graft knife system is aligned in the target site；And

Multiple skin pictures being cut open are produced by making the flap knife array be deployed into the tissue of the target site Plain and multiple defects of skin, wherein, the flap knife array response deploys in the startup of the actuator.

A kind of 410. methods, including：

Housing is positioned at target site, wherein, the housing includes flap knife array, and the flap knife array is included with one Multiple flap knifes that pattern is set；

The flap knife array is set to be deployed into the tissue of the target site；

When the target site is donor site, multiple skin pixels being cut open are produced in the target site；

When the target site is receptor site, multiple defects of skin are produced in the target site；And

Obtain the multiple skin pixels being cut open.

A kind of 411. methods, including：

Housing is positioned at donor site, wherein, the housing includes flap knife array, and the flap knife array is included with one Multiple flap knifes that pattern is set；

The flap knife array is deployed into the tissue at the donor site and produce multiple skin pixels being cut open；

The multiple skin pixels being cut open are captured at the donor site and shift the skin pixels being cut open To acceptor；

The housing is positioned at receptor site, and the flap knife array is deployed into the tissue at the receptor site In and produce multiple defects of skin；And

The multiple skin pixels being cut open are applied to the defect of skin at the receptor site.