JP2017527395A5 - - Google Patents
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- JP2017527395A5 JP2017527395A5 JP2017514490A JP2017514490A JP2017527395A5 JP 2017527395 A5 JP2017527395 A5 JP 2017527395A5 JP 2017514490 A JP2017514490 A JP 2017514490A JP 2017514490 A JP2017514490 A JP 2017514490A JP 2017527395 A5 JP2017527395 A5 JP 2017527395A5
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- cannula
- guidewire
- lumen
- target tissue
- needle
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| US11684750B2 (en) | 2019-10-08 | 2023-06-27 | Clearpoint Neuro, Inc. | Extension tube assembly and related medical fluid transfer systems and methods |
| US20230049856A1 (en) * | 2019-12-20 | 2023-02-16 | Convergascent Llc | Planning and navigation in superselective drug delivery via the tracheobronchial airway |
| KR102362824B1 (ko) * | 2020-06-01 | 2022-02-11 | 숙명여자대학교산학협력단 | 생체 내에서 항암 물질을 생성하는 방법 및 장치 |
| CN113967054A (zh) * | 2020-07-23 | 2022-01-25 | 北京术锐技术有限公司 | 一种单孔手术装置及医疗设备系统 |
| CA3200208A1 (en) * | 2020-11-25 | 2022-06-02 | New Medtek Devices Pty Ltd | "rectal anaesthesia delivery device and method" |
| IL305126A (en) | 2021-02-12 | 2023-10-01 | Rampart Health L L C | A therapeutic preparation and a method that combines immunotherapy with a cancer vaccine for the treatment of cancer |
| US20220273898A1 (en) * | 2021-02-28 | 2022-09-01 | Maurizio Radicioni | Assembly for tracheal instillation of fluid medicaments in infants supported by non-invasive ventilation |
| AU2022282840A1 (en) * | 2021-05-22 | 2023-11-02 | Snipe Medical Ltd | Tumor ablation tools and techniques |
| CN113397707B (zh) * | 2021-07-16 | 2024-12-17 | 上海市第六人民医院 | 一种辅助测量组件及其辅助测量方法 |
| DE102022115568A1 (de) * | 2022-06-22 | 2023-12-28 | Rheinisch-Westfälische Technische Hochschule Aachen, Körperschaft des öffentlichen Rechts | Katheter zur lokalen Behandlung von Tumorgewebe in intravasalen und intraluminalen Räumen |
| US20250121126A1 (en) * | 2023-10-11 | 2025-04-17 | Boston Scientific Scimed, Inc. | Endoluminal treatment systems, devices, and related methods |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5234426A (en) | 1989-06-15 | 1993-08-10 | Research Corporation Technologies, Inc. | Helical-tipped lesion localization needle device and method of using the same |
| US5807395A (en) * | 1993-08-27 | 1998-09-15 | Medtronic, Inc. | Method and apparatus for RF ablation and hyperthermia |
| US5855554A (en) | 1997-03-17 | 1999-01-05 | General Electric Company | Image guided breast lesion localization device |
| US6010500A (en) * | 1997-07-21 | 2000-01-04 | Cardiac Pathways Corporation | Telescoping apparatus and method for linear lesion ablation |
| US6205352B1 (en) | 1997-11-19 | 2001-03-20 | Oncology Innovations, Inc. | Sentinel node identification using non-isotope means |
| US6371904B1 (en) | 1998-12-24 | 2002-04-16 | Vivant Medical, Inc. | Subcutaneous cavity marking device and method |
| US6306132B1 (en) | 1999-06-17 | 2001-10-23 | Vivant Medical | Modular biopsy and microwave ablation needle delivery apparatus adapted to in situ assembly and method of use |
| US6575991B1 (en) | 1999-06-17 | 2003-06-10 | Inrad, Inc. | Apparatus for the percutaneous marking of a lesion |
| ATE386464T1 (de) | 2000-11-01 | 2008-03-15 | David Mann | Kit zur gewinnung einer endoarteriellen biopsieprobe |
| US6989004B2 (en) | 2001-02-28 | 2006-01-24 | Rex Medical, L.P. | Apparatus for delivering ablation fluid to treat lesions |
| US7077842B1 (en) * | 2001-08-03 | 2006-07-18 | Cosman Jr Eric R | Over-the-wire high frequency electrode |
| US8027712B2 (en) | 2002-10-11 | 2011-09-27 | Ion Beam Applications S.A. | Elongated markers for soft tissue volume identification |
| EP2110094B1 (en) | 2002-11-18 | 2012-06-27 | Bard Peripheral Vascular, Inc. | Apparatus and method for implanting a preloaded localization wire |
| EP1608225A4 (en) | 2003-03-26 | 2007-07-04 | Univ Minnesota | HEAT METHOD AND COMPOSITIONS |
| US20050080410A1 (en) | 2003-10-14 | 2005-04-14 | Scimed Life Systems, Inc. | Liquid infusion apparatus for radiofrequency tissue ablation |
| US20050165288A1 (en) * | 2004-01-27 | 2005-07-28 | Scimed Life Systems, Inc. | Systems and methods for treating breast tissue |
| US8409111B2 (en) | 2004-11-22 | 2013-04-02 | Bard Peripheral Vascular, Inc. | Removable localizing wire |
| US8765116B2 (en) | 2005-03-24 | 2014-07-01 | Medifocus, Inc. | Apparatus and method for pre-conditioning/fixation and treatment of disease with heat activation/release with thermoactivated drugs and gene products |
| US20070002180A1 (en) * | 2005-06-30 | 2007-01-04 | Lexmark International, Inc. | Strength parameter-based color conversion of digital images |
| US20070021803A1 (en) * | 2005-07-22 | 2007-01-25 | The Foundry Inc. | Systems and methods for neuromodulation for treatment of pain and other disorders associated with nerve conduction |
| GB2422550A (en) | 2005-12-05 | 2006-08-02 | Kanagasabapathy Chandradeva | A branched cannulation device |
| JP2010500103A (ja) | 2006-08-08 | 2010-01-07 | ピーク バイオサイエンシーズ， インコーポレイテッド | 抗癌治療のためのカテーテルおよびアレイ |
| US11395694B2 (en) * | 2009-05-07 | 2022-07-26 | St. Jude Medical, Llc | Irrigated ablation catheter with multiple segmented ablation electrodes |
| US20090171293A1 (en) | 2007-12-28 | 2009-07-02 | Wilson-Cook Medical Inc. | Self expanding wire guide |
| US8926606B2 (en) * | 2009-04-09 | 2015-01-06 | Virginia Tech Intellectual Properties, Inc. | Integration of very short electric pulses for minimally to noninvasive electroporation |
| US8361066B2 (en) * | 2009-01-12 | 2013-01-29 | Ethicon Endo-Surgery, Inc. | Electrical ablation devices |
| US20100268029A1 (en) | 2009-04-21 | 2010-10-21 | Xlumena, Inc. | Methods and apparatus for advancing a device from one body lumen to another |
| TW201203253A (en) * | 2010-07-06 | 2012-01-16 | Maxchip Electronics Corp | One time programmable memory and the manufacturing method and operation method thereof |
| US9352172B2 (en) * | 2010-09-30 | 2016-05-31 | Hologic, Inc. | Using a guide member to facilitate brachytherapy device swap |
| JP6078471B2 (ja) * | 2010-11-19 | 2017-02-08 | セント・ジュード・メディカル・エイトリアル・フィブリレーション・ディヴィジョン・インコーポレーテッド | 直流組織治療のための不関電極を有する電極カテーテル機器 |
| CN108607150B (zh) | 2013-01-30 | 2021-01-12 | 血管通路股份有限公司 | 用于静脉穿刺和导管放置的系统和方法 |
-
2014
- 2014-09-15 US US14/485,853 patent/US10376674B2/en active Active
-
2015
- 2015-09-14 BR BR112017005078A patent/BR112017005078A2/pt not_active Application Discontinuation
- 2015-09-14 JP JP2017514490A patent/JP2017527395A/ja active Pending
- 2015-09-14 EP EP20191487.6A patent/EP3760270A1/en not_active Withdrawn
- 2015-09-14 EP EP15771375.1A patent/EP3194005B1/en active Active
- 2015-09-14 ES ES15771375T patent/ES2820769T3/es active Active
- 2015-09-14 WO PCT/US2015/049951 patent/WO2016044145A1/en not_active Ceased
- 2015-09-14 AU AU2015318118A patent/AU2015318118A1/en not_active Abandoned
-
2017
- 2017-12-20 US US15/848,114 patent/US20180110964A1/en not_active Abandoned
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