JP2017523214A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2017523214A5 JP2017523214A5 JP2017506378A JP2017506378A JP2017523214A5 JP 2017523214 A5 JP2017523214 A5 JP 2017523214A5 JP 2017506378 A JP2017506378 A JP 2017506378A JP 2017506378 A JP2017506378 A JP 2017506378A JP 2017523214 A5 JP2017523214 A5 JP 2017523214A5
- Authority
- JP
- Japan
- Prior art keywords
- benzo
- imidazol
- amine
- pyridin
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 10
- 239000001257 hydrogen Substances 0.000 claims 8
- 229910052739 hydrogen Inorganic materials 0.000 claims 8
- 150000001875 compounds Chemical class 0.000 claims 7
- 150000002431 hydrogen Chemical class 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- -1 amino, aminomethyl Chemical group 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 3
- 125000000250 methylamino group Chemical group [H]N(*)C([H])([H])[H] 0.000 claims 3
- 229910052760 oxygen Inorganic materials 0.000 claims 3
- 229910052717 sulfur Inorganic materials 0.000 claims 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- WGUPNELHTHBFCR-UHFFFAOYSA-N FC(C(C(N)C1=NC2=C(N1)C=C(C=C2)C1=CC=NC=C1)C)(F)F Chemical compound FC(C(C(N)C1=NC2=C(N1)C=C(C=C2)C1=CC=NC=C1)C)(F)F WGUPNELHTHBFCR-UHFFFAOYSA-N 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 208000002193 Pain Diseases 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- 208000004296 neuralgia Diseases 0.000 claims 2
- 208000021722 neuropathic pain Diseases 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 2
- OBUBEFBSQLSRJM-CQSZACIVSA-N (1R)-1-[1-(2-methoxyethyl)-6-(1,3-oxazol-5-yl)benzimidazol-2-yl]-3-methylbutan-1-amine Chemical compound COCCN1C(=NC2=C1C=C(C=C2)C1=CN=CO1)[C@@H](CC(C)C)N OBUBEFBSQLSRJM-CQSZACIVSA-N 0.000 claims 1
- GRGLZNYSWFTRFZ-OAHLLOKOSA-N (1R)-1-[6-(3-methoxypyridin-4-yl)-1-(2,2,2-trifluoroethyl)benzimidazol-2-yl]-3-methylbutan-1-amine Chemical compound COC=1C=NC=CC=1C=1C=CC2=C(N(C(=N2)[C@@H](CC(C)C)N)CC(F)(F)F)C=1 GRGLZNYSWFTRFZ-OAHLLOKOSA-N 0.000 claims 1
- 125000004206 2,2,2-trifluoroethyl group Chemical group [H]C([H])(*)C(F)(F)F 0.000 claims 1
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 208000020925 Bipolar disease Diseases 0.000 claims 1
- HCONDFOHYSKPKQ-GOSISDBHSA-N BrC1=CC2=C(NC(=N2)[C@@H](CC(C)C)NC(OCC2=CC=CC=C2)=O)C=C1 Chemical compound BrC1=CC2=C(NC(=N2)[C@@H](CC(C)C)NC(OCC2=CC=CC=C2)=O)C=C1 HCONDFOHYSKPKQ-GOSISDBHSA-N 0.000 claims 1
- SSBWRELBLMYNAT-UHFFFAOYSA-N BrC=1C=C(C=CC=1[N+](=O)[O-])C1=CN=CO1 Chemical compound BrC=1C=C(C=CC=1[N+](=O)[O-])C1=CN=CO1 SSBWRELBLMYNAT-UHFFFAOYSA-N 0.000 claims 1
- XLJHBEVCGUKFHF-OAQYLSRUSA-N C(C)(=O)NC1=NC=CC(=C1)C1=CC2=C(NC(=N2)[C@@H](CC(C)C)N(C(OC(C)(C)C)=O)C)C=C1 Chemical compound C(C)(=O)NC1=NC=CC(=C1)C1=CC2=C(NC(=N2)[C@@H](CC(C)C)N(C(OC(C)(C)C)=O)C)C=C1 XLJHBEVCGUKFHF-OAQYLSRUSA-N 0.000 claims 1
- CSZCNWXRDUMEDD-QGZVFWFLSA-N C(C)(C)N1C(=NC2=C1C=C(C=C2)C1=CC=NC=C1)[C@@H](CC(C)C)N Chemical compound C(C)(C)N1C(=NC2=C1C=C(C=C2)C1=CC=NC=C1)[C@@H](CC(C)C)N CSZCNWXRDUMEDD-QGZVFWFLSA-N 0.000 claims 1
- NHBDOJLFEKYLSW-XMMPIXPASA-N C(C)N1C(=NC2=C1C=C(C=C2)C1=CC=NC=C1)[C@@H](CC(C)C)NC(OCC1=CC=CC=C1)=O Chemical compound C(C)N1C(=NC2=C1C=C(C=C2)C1=CC=NC=C1)[C@@H](CC(C)C)NC(OCC1=CC=CC=C1)=O NHBDOJLFEKYLSW-XMMPIXPASA-N 0.000 claims 1
- UGWJPOVWVPVOJX-CYBMUJFWSA-N C(C)N1C(=NC2=C1C=C(C=C2)C1=CN=CO1)[C@@H](CC(C)C)N Chemical compound C(C)N1C(=NC2=C1C=C(C=C2)C1=CN=CO1)[C@@H](CC(C)C)N UGWJPOVWVPVOJX-CYBMUJFWSA-N 0.000 claims 1
- WEYTXGUNNTVLLO-CQSZACIVSA-N C(C)N1C(=NC2=C1C=C(C=C2)C=1C=NNC=1)[C@@H](CC(C)C)N Chemical compound C(C)N1C(=NC2=C1C=C(C=C2)C=1C=NNC=1)[C@@H](CC(C)C)N WEYTXGUNNTVLLO-CQSZACIVSA-N 0.000 claims 1
- GORBAWIXLKJGCA-MRXNPFEDSA-N C(C)N1C(=NC2=C1C=CC(=C2)C1=CC=NC=C1)[C@@H](CC(C)C)N Chemical compound C(C)N1C(=NC2=C1C=CC(=C2)C1=CC=NC=C1)[C@@H](CC(C)C)N GORBAWIXLKJGCA-MRXNPFEDSA-N 0.000 claims 1
- ZSDFSDWOLGTBKU-CYBMUJFWSA-N C(C)N1C(=NC2=C1C=CC(=C2)C1=CN=CO1)[C@@H](CC(C)C)N Chemical compound C(C)N1C(=NC2=C1C=CC(=C2)C1=CN=CO1)[C@@H](CC(C)C)N ZSDFSDWOLGTBKU-CYBMUJFWSA-N 0.000 claims 1
- KDMHPKPZENPGTD-UHFFFAOYSA-N C(CC(C)C)C1=NC2=C(N1)C=C(C=C2)C1=CC=NC=C1 Chemical compound C(CC(C)C)C1=NC2=C(N1)C=C(C=C2)C1=CC=NC=C1 KDMHPKPZENPGTD-UHFFFAOYSA-N 0.000 claims 1
- CUHMJSMQTUZFGZ-UHFFFAOYSA-N C(CC(C)C)C1=NC2=C(N1)C=C(C=C2OC)C1=CC=NC=C1 Chemical compound C(CC(C)C)C1=NC2=C(N1)C=C(C=C2OC)C1=CC=NC=C1 CUHMJSMQTUZFGZ-UHFFFAOYSA-N 0.000 claims 1
- SBVDDRUQOBCILG-UHFFFAOYSA-N C(CC(C)C)C1=NC2=C(N1)C=C(C=C2OC)C1=CN=CO1 Chemical compound C(CC(C)C)C1=NC2=C(N1)C=C(C=C2OC)C1=CN=CO1 SBVDDRUQOBCILG-UHFFFAOYSA-N 0.000 claims 1
- KNPBFAULHMPPNR-UHFFFAOYSA-N C(CC(C)C)C1=NC2=C(N1)C=CC(=C2)C1=C(C=NC=C1)OC Chemical compound C(CC(C)C)C1=NC2=C(N1)C=CC(=C2)C1=C(C=NC=C1)OC KNPBFAULHMPPNR-UHFFFAOYSA-N 0.000 claims 1
- YGBJWWJOVOOQOV-UHFFFAOYSA-N C(CC(C)C)C1=NC2=C(N1)C=CC(=C2)C1=CC(=NC=C1)OC Chemical compound C(CC(C)C)C1=NC2=C(N1)C=CC(=C2)C1=CC(=NC=C1)OC YGBJWWJOVOOQOV-UHFFFAOYSA-N 0.000 claims 1
- FTCPBHYPFDWEIL-UHFFFAOYSA-N C(CC(C)C)C=1OC2=C(N=1)C=C(C=C2)C1=CC=NC=C1 Chemical compound C(CC(C)C)C=1OC2=C(N=1)C=C(C=C2)C1=CC=NC=C1 FTCPBHYPFDWEIL-UHFFFAOYSA-N 0.000 claims 1
- FYFGVAOHRWQJOL-UHFFFAOYSA-N C(CC(C)C)C=1OC2=C(N=1)C=CC(=C2)C1=CC=NC=C1 Chemical compound C(CC(C)C)C=1OC2=C(N=1)C=CC(=C2)C1=CC=NC=C1 FYFGVAOHRWQJOL-UHFFFAOYSA-N 0.000 claims 1
- RXMVXIZKKRGNKC-UHFFFAOYSA-N C1(CCCC1)CC1=NC2=C(N1)C=CC(=C2)C1=CC=NC=C1 Chemical compound C1(CCCC1)CC1=NC2=C(N1)C=CC(=C2)C1=CC=NC=C1 RXMVXIZKKRGNKC-UHFFFAOYSA-N 0.000 claims 1
- AVDRWLZGJUBWIM-UHFFFAOYSA-N C1(CCCC1)CC=1OC2=C(N=1)C=C(C=C2)C1=CC=NC=C1 Chemical compound C1(CCCC1)CC=1OC2=C(N=1)C=C(C=C2)C1=CC=NC=C1 AVDRWLZGJUBWIM-UHFFFAOYSA-N 0.000 claims 1
- YCZGNUVRHUUMHS-UHFFFAOYSA-N C1(CCCC1)CCC=1OC2=C(N=1)C=C(C=C2)C1=CC=NC=C1 Chemical compound C1(CCCC1)CCC=1OC2=C(N=1)C=C(C=C2)C1=CC=NC=C1 YCZGNUVRHUUMHS-UHFFFAOYSA-N 0.000 claims 1
- RUWGYADAANFYOT-QGZVFWFLSA-N C1(CCCCC1)[C@@H](N)C1=NC2=C(N1)C=C(C(=C2)C1=CN=CO1)OC Chemical compound C1(CCCCC1)[C@@H](N)C1=NC2=C(N1)C=C(C(=C2)C1=CN=CO1)OC RUWGYADAANFYOT-QGZVFWFLSA-N 0.000 claims 1
- IQVUDYIBUDRLCX-JLHYYAGUSA-N CC(/C=C(\C)/C=1OC2=C(N=1)C=C(C=C2)C1=CC=NC=C1)C Chemical compound CC(/C=C(\C)/C=1OC2=C(N=1)C=C(C=C2)C1=CC=NC=C1)C IQVUDYIBUDRLCX-JLHYYAGUSA-N 0.000 claims 1
- AOKXHKFQTKFPOX-LJQANCHMSA-N CC(C)C[C@@H](NC(=O)OC(C)(C)C)C1=NC2=CC(=CC=C2N1)C1=CC=NC=C1 Chemical compound CC(C)C[C@@H](NC(=O)OC(C)(C)C)C1=NC2=CC(=CC=C2N1)C1=CC=NC=C1 AOKXHKFQTKFPOX-LJQANCHMSA-N 0.000 claims 1
- INZSNRIGUQZMQA-QGZVFWFLSA-N CC(C)C[C@@H](NCC(F)(F)F)C1=NC2=CC(=CC=C2N1)C1=CC=NC=C1 Chemical compound CC(C)C[C@@H](NCC(F)(F)F)C1=NC2=CC(=CC=C2N1)C1=CC=NC=C1 INZSNRIGUQZMQA-QGZVFWFLSA-N 0.000 claims 1
- HKDJDEPGACCDAT-UHFFFAOYSA-N CC(CC(C)(N)C1=NC2=C(N1)C=C(C=C2)C1=CN=CO1)C Chemical compound CC(CC(C)(N)C1=NC2=C(N1)C=C(C=C2)C1=CN=CO1)C HKDJDEPGACCDAT-UHFFFAOYSA-N 0.000 claims 1
- BESJERFCFICAQQ-UHFFFAOYSA-N CC(CC(C)C1=NC2=C(N1)C=CC(=C2)C1=CC=NC=C1)C Chemical compound CC(CC(C)C1=NC2=C(N1)C=CC(=C2)C1=CC=NC=C1)C BESJERFCFICAQQ-UHFFFAOYSA-N 0.000 claims 1
- HPBBCOFETIHSSE-UHFFFAOYSA-N CC(CC(C)C=1OC2=C(N=1)C=C(C=C2)C1=CC=NC=C1)C Chemical compound CC(CC(C)C=1OC2=C(N=1)C=C(C=C2)C1=CC=NC=C1)C HPBBCOFETIHSSE-UHFFFAOYSA-N 0.000 claims 1
- XOBMHGDTOWSLKN-UHFFFAOYSA-N CC(CC(C)C=1OC2=C(N=1)C=CC(=C2)C1=CC=NC=C1)C Chemical compound CC(CC(C)C=1OC2=C(N=1)C=CC(=C2)C1=CC=NC=C1)C XOBMHGDTOWSLKN-UHFFFAOYSA-N 0.000 claims 1
- RVIHDHAVNCMMOA-UHFFFAOYSA-N CC(CC(CN)C1=NC2=C(N1)C=CC(=C2)C1=CN=CO1)C Chemical compound CC(CC(CN)C1=NC2=C(N1)C=CC(=C2)C1=CN=CO1)C RVIHDHAVNCMMOA-UHFFFAOYSA-N 0.000 claims 1
- VWROZFMIRRZOLC-UHFFFAOYSA-N CC(CC(N)C=1OC2=C(N=1)C=C(C=C2)C1=CC=NC=C1)C Chemical compound CC(CC(N)C=1OC2=C(N=1)C=C(C=C2)C1=CC=NC=C1)C VWROZFMIRRZOLC-UHFFFAOYSA-N 0.000 claims 1
- WAZIGIPMVDLWPN-UHFFFAOYSA-N CC(CC(N)C=1OC2=C(N=1)C=CC(=C2)C1=CC=NC=C1)C Chemical compound CC(CC(N)C=1OC2=C(N=1)C=CC(=C2)C1=CC=NC=C1)C WAZIGIPMVDLWPN-UHFFFAOYSA-N 0.000 claims 1
- YQWLYIGOPQNZPV-UHFFFAOYSA-N CC(CC(N)C=1SC2=C(N=1)C=C(C=C2)C1=CC=NC=C1)C Chemical compound CC(CC(N)C=1SC2=C(N=1)C=C(C=C2)C1=CC=NC=C1)C YQWLYIGOPQNZPV-UHFFFAOYSA-N 0.000 claims 1
- USGRUNWZRPDXFH-QGZVFWFLSA-N CC(C[C@@H](N)C1=NC2=C(N1)C=CC(=C2)C1=CC=NC2=CC=CC=C12)C Chemical compound CC(C[C@@H](N)C1=NC2=C(N1)C=CC(=C2)C1=CC=NC2=CC=CC=C12)C USGRUNWZRPDXFH-QGZVFWFLSA-N 0.000 claims 1
- ZSOSIIBWACDCQJ-OAHLLOKOSA-N CC(C[C@@H](N)C1=NC2=C(N1C)C=C(C=C2)C1=CC=NC=C1)C Chemical compound CC(C[C@@H](N)C1=NC2=C(N1C)C=C(C=C2)C1=CC=NC=C1)C ZSOSIIBWACDCQJ-OAHLLOKOSA-N 0.000 claims 1
- DSYMPLJTBLHHGY-OAHLLOKOSA-N CC(C[C@@H](N)C1=NC2=C(N1CC(F)(F)F)C=C(C=C2)C1=CC=NC=C1)C Chemical compound CC(C[C@@H](N)C1=NC2=C(N1CC(F)(F)F)C=C(C=C2)C1=CC=NC=C1)C DSYMPLJTBLHHGY-OAHLLOKOSA-N 0.000 claims 1
- DNNXAFXKBWDSRP-GFCCVEGCSA-N CC(C[C@@H](N)C1=NC2=C(N1CC(F)(F)F)C=C(C=C2)C1=CN=CO1)C Chemical compound CC(C[C@@H](N)C1=NC2=C(N1CC(F)(F)F)C=C(C=C2)C1=CN=CO1)C DNNXAFXKBWDSRP-GFCCVEGCSA-N 0.000 claims 1
- XVQOHPVZWUFRPQ-QGZVFWFLSA-N CC(C[C@@H](N)C1=NC2=C(N1CCC)C=C(C=C2)C1=CC=NC=C1)C Chemical compound CC(C[C@@H](N)C1=NC2=C(N1CCC)C=C(C=C2)C1=CC=NC=C1)C XVQOHPVZWUFRPQ-QGZVFWFLSA-N 0.000 claims 1
- YQWLYIGOPQNZPV-CQSZACIVSA-N CC(C[C@@H](N)C=1SC2=C(N=1)C=C(C=C2)C1=CC=NC=C1)C Chemical compound CC(C[C@@H](N)C=1SC2=C(N=1)C=C(C=C2)C1=CC=NC=C1)C YQWLYIGOPQNZPV-CQSZACIVSA-N 0.000 claims 1
- WVDJZWCMTLJXHO-MRXNPFEDSA-N CC(C[C@@H](NC)C1=NC2=C(N1)C=CC(=C2)C1=CC(=NC=C1)N)C Chemical compound CC(C[C@@H](NC)C1=NC2=C(N1)C=CC(=C2)C1=CC(=NC=C1)N)C WVDJZWCMTLJXHO-MRXNPFEDSA-N 0.000 claims 1
- HEXLPLNDMBNONB-HXUWFJFHSA-N CC(C[C@H](C1=NC2=C(N1)C=CC(=C2)C=C)NC(OCC1=CC=CC=C1)=O)C Chemical compound CC(C[C@H](C1=NC2=C(N1)C=CC(=C2)C=C)NC(OCC1=CC=CC=C1)=O)C HEXLPLNDMBNONB-HXUWFJFHSA-N 0.000 claims 1
- WPGHQABEWUESPD-AWEZNQCLSA-N CC(C[C@H](N)C1=NC2=C(N1)C=C(C=C2)C1=CC=NC=C1)C Chemical compound CC(C[C@H](N)C1=NC2=C(N1)C=C(C=C2)C1=CC=NC=C1)C WPGHQABEWUESPD-AWEZNQCLSA-N 0.000 claims 1
- ZFSBKPXBQGCRAC-NSHDSACASA-N CC(C[C@H](N)C1=NC2=C(N1)C=CC(=C2)C1=CN=CO1)C Chemical compound CC(C[C@H](N)C1=NC2=C(N1)C=CC(=C2)C1=CN=CO1)C ZFSBKPXBQGCRAC-NSHDSACASA-N 0.000 claims 1
- YQWLYIGOPQNZPV-AWEZNQCLSA-N CC(C[C@H](N)C=1SC2=C(N=1)C=C(C=C2)C1=CC=NC=C1)C Chemical compound CC(C[C@H](N)C=1SC2=C(N=1)C=C(C=C2)C1=CC=NC=C1)C YQWLYIGOPQNZPV-AWEZNQCLSA-N 0.000 claims 1
- DFAGCATYYCQOBC-CYBMUJFWSA-N CC1=NNC(=C1C1=CC2=C(NC(=N2)[C@@H](CC(C)C)N)C=C1)C Chemical compound CC1=NNC(=C1C1=CC2=C(NC(=N2)[C@@H](CC(C)C)N)C=C1)C DFAGCATYYCQOBC-CYBMUJFWSA-N 0.000 claims 1
- SCIYTJULAODGOT-UHFFFAOYSA-N CC1C(C1)C1=NC2=C(N1)C=C(C=C2)C1=CC=NC=C1 Chemical compound CC1C(C1)C1=NC2=C(N1)C=C(C=C2)C1=CC=NC=C1 SCIYTJULAODGOT-UHFFFAOYSA-N 0.000 claims 1
- IAOQKAOSZFBYKX-OAQYLSRUSA-N CN(C1=NC=CC(=C1)C1=CC2=C(NC(=N2)[C@@H](CC(C)C)N(C(OC(C)(C)C)=O)C)C=C1)C Chemical compound CN(C1=NC=CC(=C1)C1=CC2=C(NC(=N2)[C@@H](CC(C)C)N(C(OC(C)(C)C)=O)C)C=C1)C IAOQKAOSZFBYKX-OAQYLSRUSA-N 0.000 claims 1
- QJSCSJROQSCKDC-UHFFFAOYSA-N CNC(C1CCCCC1)C1=NC2=CC(=CC=C2N1)C1=CC=NC=C1 Chemical compound CNC(C1CCCCC1)C1=NC2=CC(=CC=C2N1)C1=CC=NC=C1 QJSCSJROQSCKDC-UHFFFAOYSA-N 0.000 claims 1
- IIBXCRYFEJBVJL-QGZVFWFLSA-N CNC1=NC=CC(=C1)C1=CC2=C(NC(=N2)[C@@H](CC(C)C)NC)C=C1 Chemical compound CNC1=NC=CC(=C1)C1=CC2=C(NC(=N2)[C@@H](CC(C)C)NC)C=C1 IIBXCRYFEJBVJL-QGZVFWFLSA-N 0.000 claims 1
- FKLMZLGOHCQKDF-CQSZACIVSA-N CN[C@H](CC(C)C)C1=NC2=C(N1)C=C(C=C2)C1=CN=CO1 Chemical compound CN[C@H](CC(C)C)C1=NC2=C(N1)C=C(C=C2)C1=CN=CO1 FKLMZLGOHCQKDF-CQSZACIVSA-N 0.000 claims 1
- RBMBHEOPMXLYNU-MRXNPFEDSA-N COC1=C(Br)C=C(N)C(NC(=O)[C@H](NC(=O)OC(C)(C)C)C2CCCC2)=C1 Chemical compound COC1=C(Br)C=C(N)C(NC(=O)[C@H](NC(=O)OC(C)(C)C)C2CCCC2)=C1 RBMBHEOPMXLYNU-MRXNPFEDSA-N 0.000 claims 1
- APUCMDSYCNHJOL-OAQYLSRUSA-N COC1=C(C=C2N=C(NC2=C1)[C@H](NC(=O)OC(C)(C)C)C1CCCC1)C1=CC=NC=C1 Chemical compound COC1=C(C=C2N=C(NC2=C1)[C@H](NC(=O)OC(C)(C)C)C1CCCC1)C1=CC=NC=C1 APUCMDSYCNHJOL-OAQYLSRUSA-N 0.000 claims 1
- SGUBDAQBEAIVBG-UHFFFAOYSA-N COC1=C(C=CN=C1)C1=CC=C2OC(=NC2=C1)C(N)CC(C)C Chemical compound COC1=C(C=CN=C1)C1=CC=C2OC(=NC2=C1)C(N)CC(C)C SGUBDAQBEAIVBG-UHFFFAOYSA-N 0.000 claims 1
- FJSACFMWRUQPSQ-LLVKDONJSA-N COC1=C2NC(=NC2=CC(=C1)C1=CN=CO1)[C@H](N)CC(C)C Chemical compound COC1=C2NC(=NC2=CC(=C1)C1=CN=CO1)[C@H](N)CC(C)C FJSACFMWRUQPSQ-LLVKDONJSA-N 0.000 claims 1
- FEZHQZKSBILTJY-CQSZACIVSA-N COC1=CC(=CC2=C1NC(=N2)[C@@H](CC(C)C)N)C1=C(C=NC=C1)OC Chemical compound COC1=CC(=CC2=C1NC(=N2)[C@@H](CC(C)C)N)C1=C(C=NC=C1)OC FEZHQZKSBILTJY-CQSZACIVSA-N 0.000 claims 1
- AFXYJHRIWDIVOJ-CQSZACIVSA-N COC1=CC(=CC2=C1NC(=N2)[C@@H](CC(C)C)N)C1=CC(=NC=C1)OC Chemical compound COC1=CC(=CC2=C1NC(=N2)[C@@H](CC(C)C)N)C1=CC(=NC=C1)OC AFXYJHRIWDIVOJ-CQSZACIVSA-N 0.000 claims 1
- VCQRGLFTILPFCP-JOCHJYFZSA-N COC1=CC(=CC=2NC(=NC=21)[C@@H](CC(C)C)NC(OCC1=CC=CC=C1)=O)C1=CC=NC=C1 Chemical compound COC1=CC(=CC=2NC(=NC=21)[C@@H](CC(C)C)NC(OCC1=CC=CC=C1)=O)C1=CC=NC=C1 VCQRGLFTILPFCP-JOCHJYFZSA-N 0.000 claims 1
- OANPPSSDMDKBET-HXUWFJFHSA-N COC1=CC2=C(NC(=N2)[C@@H](CC(C)C)NC(OCC2=CC=CC=C2)=O)C=C1C=C Chemical compound COC1=CC2=C(NC(=N2)[C@@H](CC(C)C)NC(OCC2=CC=CC=C2)=O)C=C1C=C OANPPSSDMDKBET-HXUWFJFHSA-N 0.000 claims 1
- IWFHVZQTSLFIKY-CQSZACIVSA-N COC1=NC=CC(=C1)C1=CC2=C(NC(=N2)[C@@H](CC(C)C)N)C=C1 Chemical compound COC1=NC=CC(=C1)C1=CC2=C(NC(=N2)[C@@H](CC(C)C)N)C=C1 IWFHVZQTSLFIKY-CQSZACIVSA-N 0.000 claims 1
- HGSMPUBZQGTNBB-UHFFFAOYSA-N COC=1C(=CC2=C(NC(=N2)C(C)(CC(C)C)N)C=1)C1=CN=CO1 Chemical compound COC=1C(=CC2=C(NC(=N2)C(C)(CC(C)C)N)C=1)C1=CN=CO1 HGSMPUBZQGTNBB-UHFFFAOYSA-N 0.000 claims 1
- UHRDUJIKSBSZNG-UHFFFAOYSA-N COC=1C(=CC2=C(NC(=N2)C(CC(C)C)NC)C=1)C1=CN=CO1 Chemical compound COC=1C(=CC2=C(NC(=N2)C(CC(C)C)NC)C=1)C1=CN=CO1 UHRDUJIKSBSZNG-UHFFFAOYSA-N 0.000 claims 1
- LDGVXLDXFJUQNT-CQSZACIVSA-N COC=1C(=CC2=C(NC(=N2)[C@@H](CC(C)C)N)C=1)C1=C(C=NC=C1)OC Chemical compound COC=1C(=CC2=C(NC(=N2)[C@@H](CC(C)C)N)C=1)C1=C(C=NC=C1)OC LDGVXLDXFJUQNT-CQSZACIVSA-N 0.000 claims 1
- LNXWZXJUNFQRSM-CQSZACIVSA-N COC=1C(=CC2=C(NC(=N2)[C@@H](CC(C)C)N)C=1)C1=CC(=NC=C1)OC Chemical compound COC=1C(=CC2=C(NC(=N2)[C@@H](CC(C)C)N)C=1)C1=CC(=NC=C1)OC LNXWZXJUNFQRSM-CQSZACIVSA-N 0.000 claims 1
- MIWSLGKJOVCGIK-CQSZACIVSA-N COC=1C=NC=CC=1C1=CC2=C(NC(=N2)[C@@H](CC(C)C)N)C=C1 Chemical compound COC=1C=NC=CC=1C1=CC2=C(NC(=N2)[C@@H](CC(C)C)N)C=C1 MIWSLGKJOVCGIK-CQSZACIVSA-N 0.000 claims 1
- NCFLTAVHNLPUGX-MRXNPFEDSA-N COCCN[C@H](CC(C)C)C1=NC2=C(N1)C=CC(=C2)C1=CN=CO1 Chemical compound COCCN[C@H](CC(C)C)C1=NC2=C(N1)C=CC(=C2)C1=CN=CO1 NCFLTAVHNLPUGX-MRXNPFEDSA-N 0.000 claims 1
- MOZFKIPQJITTSH-UHFFFAOYSA-N FC(C(CC(N)C1=NC2=C(N1)C=C(C=C2)C1=CN=CO1)C(F)(F)F)(F)F Chemical compound FC(C(CC(N)C1=NC2=C(N1)C=C(C=C2)C1=CN=CO1)C(F)(F)F)(F)F MOZFKIPQJITTSH-UHFFFAOYSA-N 0.000 claims 1
- XUTCQMYYXMURFY-UHFFFAOYSA-N FC(C(CC(N)C=1OC2=C(N=1)C=C(C=C2)C1=CC=NC=C1)C(F)(F)F)(F)F Chemical compound FC(C(CC(N)C=1OC2=C(N=1)C=C(C=C2)C1=CC=NC=C1)C(F)(F)F)(F)F XUTCQMYYXMURFY-UHFFFAOYSA-N 0.000 claims 1
- VYYQKOXPJKTAGG-UHFFFAOYSA-N FC(CC(N)C1=NC2=C(N1)C=CC(=C2)C1=CC=NC=C1)(C)C Chemical compound FC(CC(N)C1=NC2=C(N1)C=CC(=C2)C1=CC=NC=C1)(C)C VYYQKOXPJKTAGG-UHFFFAOYSA-N 0.000 claims 1
- DRMDVWVZVFXKDK-UHFFFAOYSA-N FC(CCC(N)C1=NC2=C(N1)C=C(C=C2)C1=CN=CO1)(F)F Chemical compound FC(CCC(N)C1=NC2=C(N1)C=C(C=C2)C1=CN=CO1)(F)F DRMDVWVZVFXKDK-UHFFFAOYSA-N 0.000 claims 1
- CGWIBVVNEGCNIP-UHFFFAOYSA-N FC(CCC(N)C=1OC2=C(N=1)C=C(C=C2)C1=CC=NC=C1)(F)F Chemical compound FC(CCC(N)C=1OC2=C(N=1)C=C(C=C2)C1=CC=NC=C1)(F)F CGWIBVVNEGCNIP-UHFFFAOYSA-N 0.000 claims 1
- ZPLSIQHQPBDYOF-LLVKDONJSA-N FC1=CC2=C(NC(=N2)[C@@H](CC(C)C)N)C=C1C1=CN=CO1 Chemical compound FC1=CC2=C(NC(=N2)[C@@H](CC(C)C)N)C=C1C1=CN=CO1 ZPLSIQHQPBDYOF-LLVKDONJSA-N 0.000 claims 1
- NYGIVTZBRSIGJP-GFCCVEGCSA-N FC1=NC(=CC(=C1)C1=CC2=C(NC(=N2)[C@@H](CC(C)C)N)C=C1)F Chemical compound FC1=NC(=CC(=C1)C1=CC2=C(NC(=N2)[C@@H](CC(C)C)N)C=C1)F NYGIVTZBRSIGJP-GFCCVEGCSA-N 0.000 claims 1
- GNVDCQSJVLULFZ-CYBMUJFWSA-N FC1=NC=CC(=C1)C1=CC2=C(NC(=N2)[C@@H](CC(C)C)N)C=C1 Chemical compound FC1=NC=CC(=C1)C1=CC2=C(NC(=N2)[C@@H](CC(C)C)N)C=C1 GNVDCQSJVLULFZ-CYBMUJFWSA-N 0.000 claims 1
- OFWFDFNCIDBITL-CQSZACIVSA-N FC=1C(=CC(=NC=1)OC)C1=CC2=C(NC(=N2)[C@@H](CC(C)C)N)C=C1 Chemical compound FC=1C(=CC(=NC=1)OC)C1=CC2=C(NC(=N2)[C@@H](CC(C)C)N)C=C1 OFWFDFNCIDBITL-CQSZACIVSA-N 0.000 claims 1
- PRKKWSUWARZPNV-CQSZACIVSA-N FC=1C(=CC2=C(NC(=N2)[C@@H](CC(C)C)N)C=1)C1=CC=NC=C1 Chemical compound FC=1C(=CC2=C(NC(=N2)[C@@H](CC(C)C)N)C=1)C1=CC=NC=C1 PRKKWSUWARZPNV-CQSZACIVSA-N 0.000 claims 1
- UIOIVMMOGBZAHU-CQSZACIVSA-N FC=1C=NC=CC=1C1=CC2=C(NC(=N2)[C@@H](CC(C)C)N)C=C1 Chemical compound FC=1C=NC=CC=1C1=CC2=C(NC(=N2)[C@@H](CC(C)C)N)C=C1 UIOIVMMOGBZAHU-CQSZACIVSA-N 0.000 claims 1
- 208000001640 Fibromyalgia Diseases 0.000 claims 1
- HMRLAIWTAUZAGZ-UHFFFAOYSA-N N,3-dimethyl-1-(6-pyridazin-4-yl-1H-benzimidazol-2-yl)butan-1-amine Chemical compound CNC(CC(C)C)C1=NC2=CC(=CC=C2N1)C1=CC=NN=C1 HMRLAIWTAUZAGZ-UHFFFAOYSA-N 0.000 claims 1
- GWVLDODZZDWNGK-CYBMUJFWSA-N N1=CN=C(C2=C1NC=C2)C1=CC2=C(NC(=N2)[C@@H](CC(C)C)N)C=C1 Chemical compound N1=CN=C(C2=C1NC=C2)C1=CC2=C(NC(=N2)[C@@H](CC(C)C)N)C=C1 GWVLDODZZDWNGK-CYBMUJFWSA-N 0.000 claims 1
- AVBOYNWHUMKBHH-UHFFFAOYSA-N NC1=C(C=C(C(=C1)Br)OC)NC(C(CC(C)C)N(C(OC(C)(C)C)=O)C)=O Chemical compound NC1=C(C=C(C(=C1)Br)OC)NC(C(CC(C)C)N(C(OC(C)(C)C)=O)C)=O AVBOYNWHUMKBHH-UHFFFAOYSA-N 0.000 claims 1
- DUBROJRJSZGKKX-UHFFFAOYSA-N NC1=C(C=C(C(=C1)Br)OC)NC(C(CC1CCCC1)NC(OC(C)(C)C)=O)=O Chemical compound NC1=C(C=C(C(=C1)Br)OC)NC(C(CC1CCCC1)NC(OC(C)(C)C)=O)=O DUBROJRJSZGKKX-UHFFFAOYSA-N 0.000 claims 1
- JHNAHNNFOCMWGT-UHFFFAOYSA-N NC1=C(C=C(C(=C1)Br)OC)NC(CC1CCCC1)=O Chemical compound NC1=C(C=C(C(=C1)Br)OC)NC(CC1CCCC1)=O JHNAHNNFOCMWGT-UHFFFAOYSA-N 0.000 claims 1
- ZUILMRQNLTWOOZ-GOSISDBHSA-N NC1=C(C=C(C(=C1)OC)Br)NC([C@@H](CC(C)C)NC(OCC1=CC=CC=C1)=O)=O Chemical compound NC1=C(C=C(C(=C1)OC)Br)NC([C@@H](CC(C)C)NC(OCC1=CC=CC=C1)=O)=O ZUILMRQNLTWOOZ-GOSISDBHSA-N 0.000 claims 1
- ARJHDYNRKDMKCS-CQSZACIVSA-N NC1=C(C=C(C=C1)Br)NC([C@@H](CC(C)C)NC(OC(C)(C)C)=O)=O Chemical compound NC1=C(C=C(C=C1)Br)NC([C@@H](CC(C)C)NC(OC(C)(C)C)=O)=O ARJHDYNRKDMKCS-CQSZACIVSA-N 0.000 claims 1
- FEHCFRNLECNRMI-UHFFFAOYSA-N NC1=C(C=CC(=C1)Br)NC(=O)C(CNC(OC(C)(C)C)=O)CC(C)C Chemical compound NC1=C(C=CC(=C1)Br)NC(=O)C(CNC(OC(C)(C)C)=O)CC(C)C FEHCFRNLECNRMI-UHFFFAOYSA-N 0.000 claims 1
- UVMIYUQGLWDCCB-UHFFFAOYSA-N NC1=C(C=CC(=C1)Br)NC(=O)C1CC(CCC1)C Chemical compound NC1=C(C=CC(=C1)Br)NC(=O)C1CC(CCC1)C UVMIYUQGLWDCCB-UHFFFAOYSA-N 0.000 claims 1
- VPXOSMABNJPZBK-UHFFFAOYSA-N NC1=C(C=CC(=C1)Br)NC(C(C)N1CCOCC1)=O Chemical compound NC1=C(C=CC(=C1)Br)NC(C(C)N1CCOCC1)=O VPXOSMABNJPZBK-UHFFFAOYSA-N 0.000 claims 1
- JCZGGOFINWFCEF-CYBMUJFWSA-N NC1=C(C=CC(=C1)Br)NC([C@@H](C1CC1)NC(OC(C)(C)C)=O)=O Chemical compound NC1=C(C=CC(=C1)Br)NC([C@@H](C1CC1)NC(OC(C)(C)C)=O)=O JCZGGOFINWFCEF-CYBMUJFWSA-N 0.000 claims 1
- VCCQJPFTOYJTKI-OAHLLOKOSA-N NC1=C(C=CC(=C1)Br)NC([C@@H](C1CCOCC1)NC(OC(C)(C)C)=O)=O Chemical compound NC1=C(C=CC(=C1)Br)NC([C@@H](C1CCOCC1)NC(OC(C)(C)C)=O)=O VCCQJPFTOYJTKI-OAHLLOKOSA-N 0.000 claims 1
- GQNUHWXRGSVHNR-OAHLLOKOSA-N NC1=C(C=CC(=C1)Br)NC([C@@H](CC(C)C)N(C(OC(C)(C)C)=O)C)=O Chemical compound NC1=C(C=CC(=C1)Br)NC([C@@H](CC(C)C)N(C(OC(C)(C)C)=O)C)=O GQNUHWXRGSVHNR-OAHLLOKOSA-N 0.000 claims 1
- CPDWMUHVUXQSMJ-CQSZACIVSA-N NC1=C(C=CC(=C1)Br)NC([C@@H](CC1CC1)NC(OC(C)(C)C)=O)=O Chemical compound NC1=C(C=CC(=C1)Br)NC([C@@H](CC1CC1)NC(OC(C)(C)C)=O)=O CPDWMUHVUXQSMJ-CQSZACIVSA-N 0.000 claims 1
- KQCWVUCSRUUVPQ-UHFFFAOYSA-N NC1=C(C=CC(=C1)C1=CC=NC=C1)NC(=O)C1=CC(=NN1C)C(C)(C)C Chemical compound NC1=C(C=CC(=C1)C1=CC=NC=C1)NC(=O)C1=CC(=NN1C)C(C)(C)C KQCWVUCSRUUVPQ-UHFFFAOYSA-N 0.000 claims 1
- FNBUOOJJTDNXIC-UHFFFAOYSA-N NC1=C(C=CC(=C1)C1=CC=NC=C1)NC(=O)C1C(C1)(C)C Chemical compound NC1=C(C=CC(=C1)C1=CC=NC=C1)NC(=O)C1C(C1)(C)C FNBUOOJJTDNXIC-UHFFFAOYSA-N 0.000 claims 1
- FWINUCOMTHZFBS-UHFFFAOYSA-N NC1=C(C=CC(=C1)C1=CC=NC=C1)NC(=O)C1CN(C(C1)=O)C(C)C Chemical compound NC1=C(C=CC(=C1)C1=CC=NC=C1)NC(=O)C1CN(C(C1)=O)C(C)C FWINUCOMTHZFBS-UHFFFAOYSA-N 0.000 claims 1
- CRQYQUHQHLUYQJ-UHFFFAOYSA-N NC1=C(C=CC(=C1)C1=CC=NC=C1)NC(COC(C)(C)C)=O Chemical compound NC1=C(C=CC(=C1)C1=CC=NC=C1)NC(COC(C)(C)C)=O CRQYQUHQHLUYQJ-UHFFFAOYSA-N 0.000 claims 1
- BFRNCVJRRUPGPH-UHFFFAOYSA-N NC1=C(C=CC(=C1)C1=CC=NC=C1)NC(COC(C)C)=O Chemical compound NC1=C(C=CC(=C1)C1=CC=NC=C1)NC(COC(C)C)=O BFRNCVJRRUPGPH-UHFFFAOYSA-N 0.000 claims 1
- PGHDMRBPSVHIIF-OAHLLOKOSA-N N[C@H](CC(C)C)C1=NC2=C(N1)C=CC(=C2)C1=CC(=NC=C1)C#N Chemical compound N[C@H](CC(C)C)C1=NC2=C(N1)C=CC(=C2)C1=CC(=NC=C1)C#N PGHDMRBPSVHIIF-OAHLLOKOSA-N 0.000 claims 1
- PFAOYARTIQTQHA-CYBMUJFWSA-N N[C@H](CC(C)C)C1=NC2=C(N1)C=CC(=C2)C1=CC(=NC=C1)N Chemical compound N[C@H](CC(C)C)C1=NC2=C(N1)C=CC(=C2)C1=CC(=NC=C1)N PFAOYARTIQTQHA-CYBMUJFWSA-N 0.000 claims 1
- RXXKIQAULRUAJU-LLVKDONJSA-N N[C@H](CC(C)C)C1=NC2=C(N1)C=CC(=C2)C1=NC(=NC=C1)N Chemical compound N[C@H](CC(C)C)C1=NC2=C(N1)C=CC(=C2)C1=NC(=NC=C1)N RXXKIQAULRUAJU-LLVKDONJSA-N 0.000 claims 1
- YJCDFJYYJUPYHY-CYBMUJFWSA-N N[C@H](CC(C)C)C1=NC2=C(N1)C=CC(=C2)C1=NC(=NC=C1)N(C)C Chemical compound N[C@H](CC(C)C)C1=NC2=C(N1)C=CC(=C2)C1=NC(=NC=C1)N(C)C YJCDFJYYJUPYHY-CYBMUJFWSA-N 0.000 claims 1
- QZBPXHRXYHRKMB-MRXNPFEDSA-N N[C@H](CC(C)C)C1=NC2=C(N1CCO)C=C(C=C2)C1=CC=NC=C1 Chemical compound N[C@H](CC(C)C)C1=NC2=C(N1CCO)C=C(C=C2)C1=CC=NC=C1 QZBPXHRXYHRKMB-MRXNPFEDSA-N 0.000 claims 1
- ONXWRMVBVNRCBA-CYBMUJFWSA-N N[C@H](CC(C)C)C1=NC2=C(N1CCO)C=C(C=C2)C1=CN=CO1 Chemical compound N[C@H](CC(C)C)C1=NC2=C(N1CCO)C=C(C=C2)C1=CN=CO1 ONXWRMVBVNRCBA-CYBMUJFWSA-N 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- 108091000080 Phosphotransferase Proteins 0.000 claims 1
- RYJCZDJARVRPAG-UHFFFAOYSA-N S(SC1=C(N)C=CC(=C1)C1=CC=NC=C1)C1=C(N)C=CC(=C1)C1=CC=NC=C1 Chemical compound S(SC1=C(N)C=CC(=C1)C1=CC=NC=C1)C1=C(N)C=CC(=C1)C1=CC=NC=C1 RYJCZDJARVRPAG-UHFFFAOYSA-N 0.000 claims 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 1
- MHNHWOLMXJMXPI-GOSISDBHSA-N [2-[(1R)-3-methyl-1-(phenylmethoxycarbonylamino)butyl]-3H-benzimidazol-5-yl]boronic acid Chemical compound C(C1=CC=CC=C1)OC(=O)N[C@H](CC(C)C)C1=NC2=C(N1)C=C(C=C2)B(O)O MHNHWOLMXJMXPI-GOSISDBHSA-N 0.000 claims 1
- 125000004442 acylamino group Chemical group 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- VKYFJAFRWIAOCZ-BDPMCISCSA-N benzyl N-[(1R)-3-methyl-1-(6-pyrazolidin-3-yl-1H-benzimidazol-2-yl)butyl]carbamate Chemical compound CC(C)C[C@@H](NC(=O)OCc1ccccc1)c1nc2ccc(cc2[nH]1)C1CCNN1 VKYFJAFRWIAOCZ-BDPMCISCSA-N 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 125000004122 cyclic group Chemical group 0.000 claims 1
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- OKWRBBFUPZWCPH-UHFFFAOYSA-N n-(2-amino-4-bromophenyl)-2-cyclohexylacetamide Chemical compound NC1=CC(Br)=CC=C1NC(=O)CC1CCCCC1 OKWRBBFUPZWCPH-UHFFFAOYSA-N 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 125000002971 oxazolyl group Chemical group 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 208000033808 peripheral neuropathy Diseases 0.000 claims 1
- 102000020233 phosphotransferase Human genes 0.000 claims 1
- 125000003226 pyrazolyl group Chemical group 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 201000000980 schizophrenia Diseases 0.000 claims 1
- 239000011593 sulfur Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462033425P | 2014-08-05 | 2014-08-05 | |
| US62/033,425 | 2014-08-05 | ||
| PCT/US2015/042165 WO2016022312A1 (en) | 2014-08-05 | 2015-07-27 | Heterocyclic kinase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017523214A JP2017523214A (ja) | 2017-08-17 |
| JP2017523214A5 true JP2017523214A5 (OSRAM) | 2018-03-29 |
Family
ID=53784009
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017506378A Pending JP2017523214A (ja) | 2014-08-05 | 2015-07-27 | ヘテロ環キナーゼ阻害剤 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US10035777B2 (OSRAM) |
| EP (1) | EP3177604A1 (OSRAM) |
| JP (1) | JP2017523214A (OSRAM) |
| CN (1) | CN107108552A (OSRAM) |
| WO (1) | WO2016022312A1 (OSRAM) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015006100A1 (en) | 2013-07-08 | 2015-01-15 | Bristol-Myers Squibb Company | Aryl amide kinase inhibitors |
| ES2678877T3 (es) | 2013-10-11 | 2018-08-20 | Bristol-Myers Squibb Company | Inhibidores de pirrolotriazina quinasa |
| JP7383598B2 (ja) * | 2017-07-21 | 2023-11-20 | カドモン コーポレイション，リミティド ライアビリティ カンパニー | Ｒｈｏ関連コイルドコイル含有プロテインキナーゼの阻害剤 |
| CN111601799B (zh) * | 2018-01-15 | 2023-06-09 | Ucb生物制药有限责任公司 | 作为Il-17调节剂的稠合咪唑衍生物 |
| KR102595520B1 (ko) * | 2018-07-05 | 2023-10-30 | 엘지디스플레이 주식회사 | 헤테로아릴기를 가진 벤즈아졸 유도체 및 이를 포함하는 유기전계발광소자 |
| WO2020021015A1 (en) * | 2018-07-26 | 2020-01-30 | Esteve Pharmaceuticals, S.A. | New imidazopyridine derivatives for treating pain and pain related conditions |
| EP4028005A4 (en) * | 2019-09-11 | 2023-09-20 | Prelude Therapeutics, Incorporated | Cdk inhibitors and their use as pharmaceuticals |
| CA3181676A1 (en) | 2020-04-30 | 2021-11-04 | Janssen Pharmaceutica Nv | Imidazopyridazines as modulators of il-17 |
| WO2022152852A1 (en) * | 2021-01-15 | 2022-07-21 | Glaxosmithkline Intellectual Property Development Limited | Antagonists of mrgx2 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU1836357C (ru) * | 1990-07-23 | 1993-08-23 | Др.Карл Томэ ГмбХ | Производные бензимидазола, их изомеры, смеси изомеров, гидраты или их физиологически переносимые соли, обладающие антагонистическими в отношении ангиотензина свойствами |
| EP0543263A3 (en) * | 1991-11-16 | 1993-08-25 | Dr. Karl Thomae Gmbh | Benziimidazoles, pharmaceuticals containing them and process for their preparation |
| JPH1036361A (ja) | 1996-07-25 | 1998-02-10 | Fuji Photo Film Co Ltd | ベンゾチアゾール化合物の製造方法 |
| US20040224952A1 (en) | 2003-05-07 | 2004-11-11 | Cowart Marlon D. | Fused bicyclic-substituted amines as histamine-3 receptor ligands |
| WO2010024903A1 (en) | 2008-08-29 | 2010-03-04 | Yangbo Feng | BENZO[d]OXAZOLES AND BENZO[d]THIAZOLES AS KINASE INHIBITORS |
| ES2484169T3 (es) * | 2009-05-29 | 2014-08-11 | Sumitomo Chemical Company, Limited | Agente para el tratamiento o la prevención de enfermedades asociadas a la actividad de factores neurotróficos |
| CN101798300B (zh) * | 2010-02-23 | 2013-09-25 | 陈志龙 | N-苯基吲哚甲基取代的双苯并咪唑衍生物及其降压等应用 |
| WO2013042137A1 (en) * | 2011-09-19 | 2013-03-28 | Aurigene Discovery Technologies Limited | Bicyclic heterocycles as irak4 inhibitors |
| HUE036040T2 (hu) * | 2012-03-09 | 2018-06-28 | Lexicon Pharmaceuticals Inc | Adaptor-asszociált kináz 1 gátlása fájdalom kezelésére |
| TWI527811B (zh) * | 2013-05-09 | 2016-04-01 | 吉李德科學股份有限公司 | 作爲溴結構域抑制劑的苯並咪唑衍生物 |
-
2015
- 2015-07-27 US US15/500,116 patent/US10035777B2/en active Active
- 2015-07-27 CN CN201580053792.1A patent/CN107108552A/zh active Pending
- 2015-07-27 WO PCT/US2015/042165 patent/WO2016022312A1/en not_active Ceased
- 2015-07-27 EP EP15747706.8A patent/EP3177604A1/en not_active Withdrawn
- 2015-07-27 JP JP2017506378A patent/JP2017523214A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2017523214A5 (OSRAM) | ||
| JP2019530695A5 (OSRAM) | ||
| JP2016516791A5 (OSRAM) | ||
| JP2011500806A5 (OSRAM) | ||
| JP2016525076A5 (OSRAM) | ||
| JP2019537571A5 (OSRAM) | ||
| JP2017511329A5 (OSRAM) | ||
| IL263511A (en) | 1h-pyrazolo[4,3-b]pyridines as pde1 inhibitors | |
| CA2703125A1 (en) | Pyrazinyl-substituted pyrrolo[2,3-b]pyridines, compositions thereof, and their use in the treatment of cancer | |
| RU2014132044A (ru) | Гетероциклические производные в качестве рецепторов, ассоциированных со следовыми аминами (taars) | |
| NZ609955A (en) | Sgc stimulators | |
| JP2020502230A5 (OSRAM) | ||
| HRP20180546T1 (hr) | Supstituirani benzilindazoli za uporabu kao inhibitori bub1 kinaze za liječenje hiperproliferativnih bolesti | |
| AR102852A1 (es) | Inhibidores heterocíclicos de la calicreína plasmática | |
| JP2017500364A5 (OSRAM) | ||
| JP2020512343A5 (OSRAM) | ||
| SI2981533T1 (en) | Protein Protein Kinase | |
| JP2016504290A5 (OSRAM) | ||
| JP2018535999A5 (OSRAM) | ||
| JP2013528204A5 (OSRAM) | ||
| HRP20160539T1 (hr) | Antagonisti trpv4 | |
| JP2014524461A5 (OSRAM) | ||
| JP2014528446A5 (OSRAM) | ||
| JP2017512786A5 (OSRAM) | ||
| RU2017120217A (ru) | 2-амино-5,5-дифтор-6-(фторметил)-6-фенил-3,4,5,6-тетрагидпропиридины в качестве ингибиторов bace1 |