JP2017522348A5 - - Google Patents

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Publication number
JP2017522348A5
JP2017522348A5 JP2017505221A JP2017505221A JP2017522348A5 JP 2017522348 A5 JP2017522348 A5 JP 2017522348A5 JP 2017505221 A JP2017505221 A JP 2017505221A JP 2017505221 A JP2017505221 A JP 2017505221A JP 2017522348 A5 JP2017522348 A5 JP 2017522348A5
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JP
Japan
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group
conh
formula
alkyl
substituted
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JP2017505221A
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English (en)
Japanese (ja)
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JP6599976B2 (ja
JP2017522348A (ja
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Priority claimed from PCT/EP2015/067504 external-priority patent/WO2016016366A1/en
Publication of JP2017522348A publication Critical patent/JP2017522348A/ja
Publication of JP2017522348A5 publication Critical patent/JP2017522348A5/ja
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JP2017505221A 2014-07-31 2015-07-30 置換ジヒドロピリミジノン及び好中球エラスターゼ活性の阻害薬としてのそれらの使用 Active JP6599976B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14179289.5 2014-07-31
EP14179289 2014-07-31
PCT/EP2015/067504 WO2016016366A1 (en) 2014-07-31 2015-07-30 Substituted dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity

Publications (3)

Publication Number Publication Date
JP2017522348A JP2017522348A (ja) 2017-08-10
JP2017522348A5 true JP2017522348A5 (OSRAM) 2018-09-06
JP6599976B2 JP6599976B2 (ja) 2019-10-30

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ID=51257372

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2017505221A Active JP6599976B2 (ja) 2014-07-31 2015-07-30 置換ジヒドロピリミジノン及び好中球エラスターゼ活性の阻害薬としてのそれらの使用

Country Status (4)

Country Link
US (1) US9290457B2 (OSRAM)
EP (1) EP3174860B1 (OSRAM)
JP (1) JP6599976B2 (OSRAM)
WO (1) WO2016016366A1 (OSRAM)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI581838B (zh) * 2016-03-23 2017-05-11 國立清華大學 感測式護具內襯及其防護裝置
US10406751B2 (en) * 2017-04-14 2019-09-10 Desktop Metal, Inc. Automated de-powdering with level based nesting
ES2950757T3 (es) 2017-10-06 2023-10-13 Forma Therapeutics Inc Inhibición de la peptidasa específica de la ubiquitina 30
BR112020021921A2 (pt) 2018-05-17 2021-01-26 Forma Therapeutics, Inc. compostos bicíclicos fundidos úteis como inibidores de peptidase 30 específica de ubiquitina
LT3860989T (lt) 2018-10-05 2023-06-12 Forma Therapeutics, Inc. Sulieti pirolinai, kurie veikia kaip ubikvitinui specifinės proteazės 30 (ups30) inhibitoriai
WO2021053058A1 (en) 2019-09-17 2021-03-25 Mereo Biopharma 4 Limited Alvelestat for use in the treatment of graft rejection, bronchiolitis obliterans syndrome and graft versus host disease
GB201918416D0 (en) * 2019-12-13 2020-01-29 Z Factor Ltd Compounds and their use for the treatment of Alpha1-Antitrypsin deficiency
DK4106757T3 (da) 2020-04-16 2023-10-23 Mereo Biopharma 4 Ltd Fremgangsmåder der involverer neutrofil elastase-inhibitor alvelestat til behandling af luftvejssygdom medieret af alpha-1-antitrypsin-mangel
AU2022373971A1 (en) 2021-10-20 2024-04-04 Mereo Biopharma 4 Limited Neutrophil elastase inhibitors for use in the treatment of fibrosis

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CA2470813A1 (en) 2001-12-20 2003-07-03 Bayer Healthcare Ag 1,4-dihydro-1,4-diphenylpyridine derivatives
US7230017B2 (en) 2002-08-27 2007-06-12 Bayer Healthcare Ag Dihydropyridinone derivatives
GB0219896D0 (en) 2002-08-27 2002-10-02 Bayer Ag Dihydropyridine derivatives
GB2392910A (en) * 2002-09-10 2004-03-17 Bayer Ag 2-Oxopyrimidine derivatives and their use as human leukocyte elastase inhibitors
PL375647A1 (en) 2002-09-10 2005-12-12 Bayer Healthcare Ag Pyrimidinone derivatives as therapeutic agents against acute and chronic inflammatory, ischaemic and remodelling processes
WO2004024701A1 (en) 2002-09-10 2004-03-25 Bayer Healthcare Ag Heterocyclic derivatives
WO2005082863A2 (en) 2004-02-26 2005-09-09 Bayer Healthcare Ag 1,4 diaryl-dihydropyrimidin-2 ones and their use as a human neutrophil elastase inhibitors
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GB0502258D0 (en) 2005-02-03 2005-03-09 Argenta Discovery Ltd Compounds and their use
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JP4999920B2 (ja) 2006-05-04 2012-08-15 プルマジェン セラピューティクス (インフラメーション) リミテッド テトラヒドロピロロピリミジンジオン類およびヒト好中球エラスターゼ阻害薬としてのそれらの使用
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WO2009013444A1 (en) 2007-07-25 2009-01-29 Argenta Discovery Limited Tetrahydropyrrolopyrimidinediones and their use as human neutrophil elastase inhibitors
DE102006031314A1 (de) 2006-07-01 2008-01-03 Bayer Healthcare Aktiengesellschaft Verwendung von 1,4-Diaryl-dihydropyrimidin-2-on-Derivaten zur Behandlung der pulmonalen arteriellen Hyptertonie
US20100010024A1 (en) 2006-07-01 2010-01-14 Bayer Healthcare Ag Use of1,4-diaryl-dihydropyrimidine-2-on derivatives for treating pulmonary arterial hypertension
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WO2009060206A1 (en) 2007-11-07 2009-05-14 Argenta Discovery Limited 3,4,6,7-tetrahydro-1h-pyrrolo[3,4-d]pyrimidine-2,5-diones and their therapeutic use
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DE102008022521A1 (de) 2008-05-07 2009-11-12 Bayer Schering Pharma Aktiengesellschaft 1,4-Diaryl-pyrimidopyridazin-2,5-dione und ihre Verwendung
DE102009004197A1 (de) 2009-01-09 2010-07-15 Bayer Schering Pharma Aktiengesellschaft Heterocyclisch anellierte Diaryldihydropyrimidin-Derivate und ihre Verwendung
DE102009016553A1 (de) 2009-04-06 2010-10-07 Bayer Schering Pharma Aktiengesellschaft Sulfonamid- und Sulfoximin-substituierte Diaryldihydropyrimidinone und ihre Verwendung
GB201004179D0 (en) 2010-03-12 2010-04-28 Pulmagen Therapeutics Inflamma Enzyme inhibitors
GB201004178D0 (en) 2010-03-12 2010-04-28 Pulmagen Therapeutics Inflamma Enzyme inhibitors
JP2013177318A (ja) 2010-06-30 2013-09-09 Dainippon Sumitomo Pharma Co Ltd ジヒドロピリミジノン誘導体およびその医薬用途
CN104024241B (zh) 2011-08-01 2016-01-20 大日本住友制药株式会社 尿嘧啶衍生物和其用于医学目的的用途
KR20140060513A (ko) 2011-09-14 2014-05-20 키에시 파르마슈티시 엣스. 피. 에이. 인체 호중구 엘라스타제 억제제인 테트라히드로트리아졸로피리미딘 유도체
US9102624B2 (en) 2012-08-23 2015-08-11 Boehringer Ingelheim International Gmbh Substituted 4-pyridones and their use as inhibitors of neutrophil elastase activity
US20140057920A1 (en) 2012-08-23 2014-02-27 Boehringer Ingelheim International Gmbh Substituted 4-pyridones and their use as inhibitors of neutrophil elastase activity
US20140057926A1 (en) 2012-08-23 2014-02-27 Boehringer Ingelheim International Gmbh Substituted 4-pyridones and their use as inhibitors of neutrophil elastase activity

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