JP2017521486A5 - - Google Patents
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- Publication number
- JP2017521486A5 JP2017521486A5 JP2017516251A JP2017516251A JP2017521486A5 JP 2017521486 A5 JP2017521486 A5 JP 2017521486A5 JP 2017516251 A JP2017516251 A JP 2017516251A JP 2017516251 A JP2017516251 A JP 2017516251A JP 2017521486 A5 JP2017521486 A5 JP 2017521486A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- pharmaceutical composition
- peptide
- pharmaceutically acceptable
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462007159P | 2014-06-03 | 2014-06-03 | |
| US62/007,159 | 2014-06-03 | ||
| PCT/US2015/033509 WO2015187540A1 (en) | 2014-06-03 | 2015-06-01 | Peptide-drug conjugates |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019107602A Division JP2019189623A (ja) | 2014-06-03 | 2019-06-10 | ペプチド−薬物複合体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017521486A JP2017521486A (ja) | 2017-08-03 |
| JP2017521486A5 true JP2017521486A5 (OSRAM) | 2018-12-20 |
| JP6539729B2 JP6539729B2 (ja) | 2019-07-03 |
Family
ID=54700553
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017516251A Active JP6539729B2 (ja) | 2014-06-03 | 2015-06-01 | ペプチド−薬物複合体 |
| JP2019107602A Pending JP2019189623A (ja) | 2014-06-03 | 2019-06-10 | ペプチド−薬物複合体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019107602A Pending JP2019189623A (ja) | 2014-06-03 | 2019-06-10 | ペプチド−薬物複合体 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US9579317B2 (OSRAM) |
| EP (1) | EP3152223B1 (OSRAM) |
| JP (2) | JP6539729B2 (OSRAM) |
| CN (1) | CN106456799B (OSRAM) |
| AU (1) | AU2015270924B2 (OSRAM) |
| CA (1) | CA2951049C (OSRAM) |
| ES (1) | ES2857192T3 (OSRAM) |
| MA (1) | MA40030A (OSRAM) |
| WO (1) | WO2015187540A1 (OSRAM) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2015306574B2 (en) * | 2014-08-22 | 2020-07-23 | Yafei Shanghai Biology Medicine Science & Technology Co. Ltd. | Specifically activated micromolecular target coupling body in tumor microenvironment and use thereof |
| AU2017236431A1 (en) * | 2016-03-24 | 2018-09-27 | Bayer Pharma Aktiengesellschaft | Prodrugs of cytotoxic active agents having enzymatically cleavable groups |
| CN107375288B (zh) | 2016-05-16 | 2019-08-23 | 博瑞生物医药（苏州）股份有限公司 | 多臂的聚合靶向抗癌偶联物 |
| EP3558386A1 (de) | 2016-12-21 | 2019-10-30 | Bayer Aktiengesellschaft | Prodrugs von cytotoxischen wirkstoffen mit enzymatisch spaltbaren gruppen |
| CN108314703B (zh) * | 2017-01-17 | 2022-02-01 | 亚飞（上海）生物医药科技有限公司 | 分子定点靶向和激活的激酶抑制剂的制备和用途 |
| US11191843B2 (en) | 2017-04-21 | 2021-12-07 | Brightgene Bio-Medical Technology Co., Ltd. | Multi-arm targeting anti-cancer conjugate |
| CN107670048B (zh) * | 2017-08-30 | 2019-04-26 | 南京明臻医药科技有限公司 | 具有协同抗癌活性的中间体药物和聚乙二醇偶联协同抗癌药物、及其制备方法和应用 |
| EP3908307A4 (en) * | 2019-01-07 | 2022-10-12 | Cenna Biosciences Inc. | NOVEL PEPTIDES AND USES THEREOF |
| AU2020253560A1 (en) * | 2019-04-05 | 2021-11-25 | Prolynx Llc | Improved conjugation linkers |
| WO2020241445A1 (ja) * | 2019-05-24 | 2020-12-03 | 学校法人慈恵大学 | 薬剤、肺胞の洗浄用の薬液、及び、ネブライザー |
| JP2023548136A (ja) * | 2020-10-30 | 2023-11-15 | アバクタ・ライフ・サイエンシーズ・リミテッド | 酵素活性化血清半減期延長型治療用コンジュゲート |
| JP2023548310A (ja) * | 2020-10-30 | 2023-11-16 | アバクタ・ライフ・サイエンシーズ・リミテッド | Ｆａｐ活性化血清半減期延長型治療用コンジュゲート |
| CN115850288B (zh) * | 2022-11-25 | 2025-03-21 | 中科帅天医药(深圳)有限公司 | 一种丝裂霉素c前体药物及其制备方法和应用 |
| CN120835795A (zh) * | 2023-03-09 | 2025-10-24 | 拜斯科技术开发有限公司 | 双环毒素偶联物及其中间体的合成 |
| CN117683079B (zh) * | 2023-12-12 | 2025-04-04 | 九洲药业(杭州)有限公司 | 一种抗体偶联药物连接子的固相合成方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3803223A (en) * | 1970-07-20 | 1974-04-09 | Searle & Co | 3-amino-n-substituted succinamic acids and intermediates thereto |
| US6214345B1 (en) * | 1993-05-14 | 2001-04-10 | Bristol-Myers Squibb Co. | Lysosomal enzyme-cleavable antitumor drug conjugates |
| JP2003523407A (ja) * | 2000-02-24 | 2003-08-05 | ジェネンテック・インコーポレーテッド | カスパーゼ活性化プロドラック療法 |
| US8314060B2 (en) | 2000-09-05 | 2012-11-20 | Biosight Ltd. | Peptide conjugated anti-cancer prodrugs |
| AU2004248138B2 (en) * | 2003-05-29 | 2009-09-03 | The Scripps Research Institute | Targeted delivery to legumain-expressing cells |
| WO2007064759A2 (en) * | 2005-11-29 | 2007-06-07 | The Scripps Research Institute | Inhibiting tumour cell invasion, metastasis and angiogenesis through targetting legumain |
| EP2266964B1 (en) * | 2009-06-22 | 2013-01-09 | KTB Tumorforschungsgesellschaft mbH | Acid-labile trigger units |
| US8394922B2 (en) * | 2009-08-03 | 2013-03-12 | Medarex, Inc. | Antiproliferative compounds, conjugates thereof, methods therefor, and uses thereof |
| US20140057844A1 (en) | 2010-12-03 | 2014-02-27 | Tin Tin Su | Chemical entities and therapeutic uses thereof |
-
2015
- 2015-06-01 CA CA2951049A patent/CA2951049C/en active Active
- 2015-06-01 MA MA040030A patent/MA40030A/fr unknown
- 2015-06-01 WO PCT/US2015/033509 patent/WO2015187540A1/en not_active Ceased
- 2015-06-01 EP EP15803150.0A patent/EP3152223B1/en active Active
- 2015-06-01 JP JP2017516251A patent/JP6539729B2/ja active Active
- 2015-06-01 US US14/726,897 patent/US9579317B2/en active Active
- 2015-06-01 AU AU2015270924A patent/AU2015270924B2/en active Active
- 2015-06-01 CN CN201580029854.5A patent/CN106456799B/zh active Active
- 2015-06-01 ES ES15803150T patent/ES2857192T3/es active Active
-
2017
- 2017-01-27 US US15/417,615 patent/US20170232023A1/en not_active Abandoned
-
2019
- 2019-06-10 JP JP2019107602A patent/JP2019189623A/ja active Pending
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