JP2017521195A - 薬剤送出装置 - Google Patents
薬剤送出装置 Download PDFInfo
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- JP2017521195A JP2017521195A JP2017504099A JP2017504099A JP2017521195A JP 2017521195 A JP2017521195 A JP 2017521195A JP 2017504099 A JP2017504099 A JP 2017504099A JP 2017504099 A JP2017504099 A JP 2017504099A JP 2017521195 A JP2017521195 A JP 2017521195A
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- delivery device
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- 238000012377 drug delivery Methods 0.000 title claims abstract description 74
- 230000007246 mechanism Effects 0.000 claims abstract description 73
- 239000006199 nebulizer Substances 0.000 claims abstract description 51
- 239000007788 liquid Substances 0.000 claims description 64
- 239000003814 drug Substances 0.000 claims description 34
- 229940079593 drug Drugs 0.000 claims description 18
- 238000000605 extraction Methods 0.000 claims description 7
- 239000000725 suspension Substances 0.000 claims description 3
- 239000011248 coating agent Substances 0.000 claims 1
- 238000000576 coating method Methods 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 abstract description 9
- 238000000034 method Methods 0.000 abstract description 8
- 230000008569 process Effects 0.000 abstract description 7
- 238000010304 firing Methods 0.000 description 12
- 239000012530 fluid Substances 0.000 description 10
- 238000005507 spraying Methods 0.000 description 9
- 239000007921 spray Substances 0.000 description 8
- 239000000243 solution Substances 0.000 description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
- 230000000903 blocking effect Effects 0.000 description 6
- 239000000443 aerosol Substances 0.000 description 5
- 239000011888 foil Substances 0.000 description 5
- 239000008194 pharmaceutical composition Substances 0.000 description 5
- 230000004888 barrier function Effects 0.000 description 4
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 4
- 230000002829 reductive effect Effects 0.000 description 4
- 238000007906 compression Methods 0.000 description 3
- 239000002184 metal Substances 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 230000036961 partial effect Effects 0.000 description 3
- 238000005192 partition Methods 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 102000004877 Insulin Human genes 0.000 description 2
- 108090001061 Insulin Proteins 0.000 description 2
- 230000005540 biological transmission Effects 0.000 description 2
- 230000006835 compression Effects 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 229940125396 insulin Drugs 0.000 description 2
- 239000003380 propellant Substances 0.000 description 2
- 230000000284 resting effect Effects 0.000 description 2
- 230000002441 reversible effect Effects 0.000 description 2
- 238000009423 ventilation Methods 0.000 description 2
- 206010002091 Anaesthesia Diseases 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 230000037005 anaesthesia Effects 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000005553 drilling Methods 0.000 description 1
- 239000002783 friction material Substances 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000003595 mist Substances 0.000 description 1
- 239000012457 nonaqueous media Substances 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000007971 pharmaceutical suspension Substances 0.000 description 1
- 239000004810 polytetrafluoroethylene Substances 0.000 description 1
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 1
- 230000037452 priming Effects 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 239000004447 silicone coating Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 239000012780 transparent material Substances 0.000 description 1
- 238000013022 venting Methods 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
- A61M11/006—Sprayers or atomisers specially adapted for therapeutic purposes operated by applying mechanical pressure to the liquid to be sprayed or atomised
- A61M11/007—Syringe-type or piston-type sprayers or atomisers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0001—Details of inhalators; Constructional features thereof
- A61M15/002—Details of inhalators; Constructional features thereof with air flow regulating means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0065—Inhalators with dosage or measuring devices
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
- B05B11/0005—Components or details
- B05B11/0037—Containers
- B05B11/0054—Cartridges, i.e. containers specially designed for easy attachment to or easy removal from the rest of the sprayer
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
- B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
- B05B11/02—Membranes or pistons acting on the contents inside the container, e.g. follower pistons
- B05B11/028—Pistons separating the content remaining in the container from the atmospheric air to compensate underpressure inside the container
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0001—Details of inhalators; Constructional features thereof
- A61M15/0021—Mouthpieces therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0065—Inhalators with dosage or measuring devices
- A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/20—Valves specially adapted to medical respiratory devices
- A61M16/208—Non-controlled one-way valves, e.g. exhalation, check, pop-off non-rebreathing valves
- A61M16/209—Relief valves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/04—Liquids
- A61M2202/0468—Liquids non-physiological
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/02—General characteristics of the apparatus characterised by a particular materials
- A61M2205/0238—General characteristics of the apparatus characterised by a particular materials the material being a coating or protective layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/27—General characteristics of the apparatus preventing use
- A61M2205/273—General characteristics of the apparatus preventing use preventing reuse, e.g. of disposables
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
- A61M2205/583—Means for facilitating use, e.g. by people with impaired vision by visual feedback
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
- B05B11/0005—Components or details
- B05B11/0037—Containers
- B05B11/0038—Inner container disposed in an outer shell or outer casing
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
- B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
- B05B11/10—Pump arrangements for transferring the contents from the container to a pump chamber by a sucking effect and forcing the contents out through the dispensing nozzle
- B05B11/109—Pump arrangements for transferring the contents from the container to a pump chamber by a sucking effect and forcing the contents out through the dispensing nozzle the dispensing stroke being affected by the stored energy of a spring
- B05B11/1091—Pump arrangements for transferring the contents from the container to a pump chamber by a sucking effect and forcing the contents out through the dispensing nozzle the dispensing stroke being affected by the stored energy of a spring being first hold in a loaded state by locking means or the like, then released
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Anesthesiology (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Mechanical Engineering (AREA)
- Biophysics (AREA)
- Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Vascular Medicine (AREA)
Abstract
Description
11 本体
12 ピストン
13 クリンプ
14 隔壁
15 液体
16 容器
21 下部ケース
22 上部ケース
23 コネクタ
25 矢印
26 底部
27 ばね
30 機構
31 シリンダ
32 空洞部
33 ピストン
34 復帰
36 通路
37 毛細管
38 弁
41 ロッド
42 ボール
43 シリンダ
44 凹部
46 壁部
47 矢印
48 矢印
50 カートリッジアセンブリ
51 クロージャ/ヘッド
51a ゴムキャップ
51b シール
52 ピストン
54 バッグ
57 キャニスタ
58 箔
59 穴
64 過充填
65 作動要素
71 ロッド
72 歯型
73 縁部
76 歯
77 歯
78 矢印
79 矢印
100 薬剤送出装置
101 ネブライザ
105 圧力発生器
106 ホルダ
107 駆動ばね
108 遮断要素
109 搬送管
110 逆止弁
111 圧力チャンバ
112 ノズル
113 マウスピース
114 エアロゾル
115 給気用開口部
116 上側ハウジング部分
117 内側部分
117a 内側部分の上部
117b 内側部分の下部
118 ハウジング部分(下部)
119 保持要素
121 基部
122 通気孔
124 ネブライザハウジング
Claims (15)
- 薬液又は薬剤懸濁液などの薬剤を含む液体(15)のための薬剤送出装置(100)であって、
内容物としての前記液体(15)のための圧壊性/圧縮性容器(16)を含むカートリッジ(10)と、
前記容器(16)を圧壊/圧縮するのに役立ち、及び/又は前記容器(16)の前記内容物を加圧する機構(30)と、
を備え、
前記機構(30)は、少なくとも本質的に前記内容物の抽出中にのみ前記内容物を加圧するように適合され、及び/又は、
前記機構(30)は、圧壊した容器(16)が再び膨張するのを防ぐように適合され、及び/又は、
前記機構(30)は、前記内容物の抽出後及び/又は前記薬剤送出装置(100)の不使用時に、前記内容物に加わる圧力を低下させるように適合される、
ことを特徴とする薬剤送出装置。 - 前記容器(16)は、可動ピストン/シリンダ構成によって形成され、或いは前記カートリッジ(10)は、可動ピストン/シリンダ構成を含む、
請求項1に記載の薬剤送出装置。 - 前記シリンダ/シリンダ構成のピストン(12)又はシリンダの少なくとも一方が、前記ピストン(12)と前記シリンダとの間の摩擦を低減するためにコーティングを含む、
請求項2に記載の薬剤送出装置。 - 前記容器は、圧壊性ベローズ又はバッグ(54)である、
請求項1から3のいずれか1項に記載の薬剤送出装置。 - 前記機構(30)は、ハウジングに対する前記カートリッジ(10)のストローク状の動き、及び/又は前記薬剤送出装置(100)の装填/後引/引張によって作動する、
請求項1から4のいずれか1項に記載の薬剤送出装置。 - 前記機構(30)は、空気ばねを含む、
請求項1から5のいずれか1項に記載の薬剤送出装置。 - 前記空気ばねは、空洞部(32)を含み、該空洞部(32)において、前記薬剤送出装置(100)の後引又は引張時に空気が圧縮され、従って前記内容物が加圧され、及び/又は前記薬剤送出装置(100)の発射/作動時に空気が膨張する、
請求項6に記載の薬剤送出装置。 - 前記機構(30)は、具体的には前記空気ばねが前記内容物を一時的に及び/又は少なくとも本質的に前記内容物の抽出中にのみ加圧できるように、前記空気ばね又は前記空洞部(32)に関連する弁及び/又は空気漏出経路を含む、
請求項6又は7に記載の薬剤送出装置。 - 前記弁は、前記空気漏出経路内に配置され、及び/又は該空気漏出経路を通る空気流を制御する、
請求項8に記載の薬剤送出装置。 - 前記機構(30)は、カートリッジプランジャ又はピストン(12)を押圧する、
請求項1から9のいずれか1項に記載の薬剤送出装置。 - 前記機構(30)は、前記カートリッジプランジャ又はピストン(12)を押圧して前記液体(15)を圧縮又は加圧するための、好ましくは一方向の摩擦係合をもたらす、
請求項10に記載の薬剤送出装置。 - 前記機構(30)は、具体的には前記薬剤送出装置(100)の装填又は後引又は引張時に前記ピストン(12)又は前記容器(16)に作用する摩擦要素、具体的にはボール(42)を含む、
請求項1から11のいずれか1項に記載の薬剤送出装置。 - 前記機構(30)は、具体的には圧壊/圧縮した容器(16)が再び膨張するのを防ぐラチェット構成を含む、
請求項1から12のいずれか1項に記載の薬剤送出装置。 - 前記カートリッジ(10)及び前記機構(30)は、カートリッジアセンブリ(50)を形成する、
請求項1から13のいずれか1項に記載の薬剤送出装置。 - 前記薬剤送出装置(100)は、ネブライザ(101)、具体的には吸入器であり、或いはネブライザ(101)、具体的には吸入器を形成する、
請求項1から14のいずれか1項に記載の薬剤送出装置。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB1413181.7 | 2014-07-25 | ||
GBGB1413181.7A GB201413181D0 (en) | 2014-07-25 | 2014-07-25 | Inhaler cartridge system |
PCT/EP2015/001534 WO2016012102A1 (en) | 2014-07-25 | 2015-07-24 | Drug delivery device |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2017521195A true JP2017521195A (ja) | 2017-08-03 |
JP2017521195A5 JP2017521195A5 (ja) | 2018-09-06 |
JP6810684B2 JP6810684B2 (ja) | 2021-01-06 |
Family
ID=51587218
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2017504099A Active JP6810684B2 (ja) | 2014-07-25 | 2015-07-24 | 薬剤送出装置 |
Country Status (9)
Country | Link |
---|---|
US (1) | US11207474B2 (ja) |
EP (1) | EP3171921B1 (ja) |
JP (1) | JP6810684B2 (ja) |
DK (1) | DK3171921T3 (ja) |
ES (1) | ES2893810T3 (ja) |
GB (1) | GB201413181D0 (ja) |
HU (1) | HUE056904T2 (ja) |
PL (1) | PL3171921T3 (ja) |
WO (1) | WO2016012102A1 (ja) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2021520243A (ja) * | 2018-05-04 | 2021-08-19 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ネブライザ及び容器 |
JP2022506180A (ja) * | 2018-11-09 | 2022-01-17 | ソフトハレ エヌヴイ | 吸入装置のためのリザーバ |
JP2022511564A (ja) * | 2018-12-18 | 2022-01-31 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | カートリッジを生成する方法 |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB201319150D0 (en) * | 2013-10-30 | 2013-12-11 | British American Tobacco Co | An inhaler |
GB201413181D0 (en) | 2014-07-25 | 2014-09-10 | Dunne Consultancy Services Ltd | Inhaler cartridge system |
EP3407944B1 (en) * | 2016-01-25 | 2019-12-11 | Boehringer Ingelheim International GmbH | Nebulizer |
CN105901775A (zh) * | 2016-06-03 | 2016-08-31 | 深圳市合元科技有限公司 | 喷射式雾化装置 |
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Also Published As
Publication number | Publication date |
---|---|
US11207474B2 (en) | 2021-12-28 |
JP6810684B2 (ja) | 2021-01-06 |
WO2016012102A1 (en) | 2016-01-28 |
HUE056904T2 (hu) | 2022-03-28 |
US20170203056A1 (en) | 2017-07-20 |
PL3171921T3 (pl) | 2021-12-20 |
ES2893810T3 (es) | 2022-02-10 |
EP3171921B1 (en) | 2021-08-11 |
EP3171921A1 (en) | 2017-05-31 |
DK3171921T3 (da) | 2021-11-15 |
GB201413181D0 (en) | 2014-09-10 |
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