JP2017520609A5 - - Google Patents
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- JP2017520609A5 JP2017520609A5 JP2017502620A JP2017502620A JP2017520609A5 JP 2017520609 A5 JP2017520609 A5 JP 2017520609A5 JP 2017502620 A JP2017502620 A JP 2017502620A JP 2017502620 A JP2017502620 A JP 2017502620A JP 2017520609 A5 JP2017520609 A5 JP 2017520609A5
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- 239000003814 drug Substances 0.000 claims 25
- 239000008194 pharmaceutical composition Substances 0.000 claims 25
- BCFGMOOMADDAQU-UHFFFAOYSA-N lapatinib Chemical compound O1C(CNCCS(=O)(=O)C)=CC=C1C1=CC=C(N=CN=C2NC=3C=C(Cl)C(OCC=4C=C(F)C=CC=4)=CC=3)C2=C1 BCFGMOOMADDAQU-UHFFFAOYSA-N 0.000 claims 22
- 125000003275 alpha amino acid group Chemical group 0.000 claims 21
- 102100029986 Receptor tyrosine-protein kinase erbB-3 Human genes 0.000 claims 20
- 101710100969 Receptor tyrosine-protein kinase erbB-3 Proteins 0.000 claims 20
- 239000003795 chemical substances by application Substances 0.000 claims 20
- 229940124597 therapeutic agent Drugs 0.000 claims 19
- 239000002136 L01XE07 - Lapatinib Substances 0.000 claims 18
- 239000012634 fragment Substances 0.000 claims 14
- 239000003112 inhibitor Substances 0.000 claims 14
- 229960004891 lapatinib Drugs 0.000 claims 14
- GTTBEUCJPZQMDZ-UHFFFAOYSA-N erlotinib hydrochloride Chemical compound [H+].[Cl-].C=12C=C(OCCOC)C(OCCOC)=CC2=NC=NC=1NC1=CC=CC(C#C)=C1 GTTBEUCJPZQMDZ-UHFFFAOYSA-N 0.000 claims 12
- 102000001301 EGF receptor Human genes 0.000 claims 10
- 108060006698 EGF receptor Proteins 0.000 claims 8
- 229940125497 HER2 kinase inhibitor Drugs 0.000 claims 8
- 229950002826 canertinib Drugs 0.000 claims 8
- XGALLCVXEZPNRQ-UHFFFAOYSA-N gefitinib Chemical compound C=12C=C(OCCCN3CCOCC3)C(OC)=CC2=NC=NC=1NC1=CC=C(F)C(Cl)=C1 XGALLCVXEZPNRQ-UHFFFAOYSA-N 0.000 claims 8
- 229950008001 matuzumab Drugs 0.000 claims 8
- 229960005395 cetuximab Drugs 0.000 claims 7
- 229940121647 egfr inhibitor Drugs 0.000 claims 7
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 claims 7
- 206010033128 Ovarian cancer Diseases 0.000 claims 6
- 229940082789 erbitux Drugs 0.000 claims 6
- 239000003446 ligand Substances 0.000 claims 6
- 229940124302 mTOR inhibitor Drugs 0.000 claims 6
- 239000003628 mammalian target of rapamycin inhibitor Substances 0.000 claims 6
- 239000002935 phosphatidylinositol 3 kinase inhibitor Substances 0.000 claims 6
- 229960000575 trastuzumab Drugs 0.000 claims 6
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 5
- 229940116355 PI3 kinase inhibitor Drugs 0.000 claims 5
- 230000011664 signaling Effects 0.000 claims 5
- SYYMNUFXRFAELA-BTQNPOSSSA-N 4-[4-[[(1r)-1-phenylethyl]amino]-7h-pyrrolo[2,3-d]pyrimidin-6-yl]phenol;hydrobromide Chemical compound Br.N([C@H](C)C=1C=CC=CC=1)C(C=1C=2)=NC=NC=1NC=2C1=CC=C(O)C=C1 SYYMNUFXRFAELA-BTQNPOSSSA-N 0.000 claims 4
- HKVAMNSJSFKALM-GKUWKFKPSA-N Everolimus Chemical compound C1C[C@@H](OCCO)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 HKVAMNSJSFKALM-GKUWKFKPSA-N 0.000 claims 4
- 239000005411 L01XE02 - Gefitinib Substances 0.000 claims 4
- 239000005551 L01XE03 - Erlotinib Substances 0.000 claims 4
- 102100029981 Receptor tyrosine-protein kinase erbB-4 Human genes 0.000 claims 4
- 101710100963 Receptor tyrosine-protein kinase erbB-4 Proteins 0.000 claims 4
- 229960001433 erlotinib Drugs 0.000 claims 4
- 229960002584 gefitinib Drugs 0.000 claims 4
- 229940084651 iressa Drugs 0.000 claims 4
- 229950010203 nimotuzumab Drugs 0.000 claims 4
- 229960001972 panitumumab Drugs 0.000 claims 4
- 229940120982 tarceva Drugs 0.000 claims 4
- 229940094060 tykerb Drugs 0.000 claims 4
- STUWGJZDJHPWGZ-LBPRGKRZSA-N (2S)-N1-[4-methyl-5-[2-(1,1,1-trifluoro-2-methylpropan-2-yl)-4-pyridinyl]-2-thiazolyl]pyrrolidine-1,2-dicarboxamide Chemical compound S1C(C=2C=C(N=CC=2)C(C)(C)C(F)(F)F)=C(C)N=C1NC(=O)N1CCC[C@H]1C(N)=O STUWGJZDJHPWGZ-LBPRGKRZSA-N 0.000 claims 3
- 108020004459 Small interfering RNA Proteins 0.000 claims 3
- 229950010482 alpelisib Drugs 0.000 claims 3
- 125000000539 amino acid group Chemical group 0.000 claims 3
- 229950006418 dactolisib Drugs 0.000 claims 3
- JOGKUKXHTYWRGZ-UHFFFAOYSA-N dactolisib Chemical compound O=C1N(C)C2=CN=C3C=CC(C=4C=C5C=CC=CC5=NC=4)=CC3=C2N1C1=CC=C(C(C)(C)C#N)C=C1 JOGKUKXHTYWRGZ-UHFFFAOYSA-N 0.000 claims 3
- 230000001419 dependent effect Effects 0.000 claims 3
- 229960005167 everolimus Drugs 0.000 claims 3
- 229950008835 neratinib Drugs 0.000 claims 3
- ZNHPZUKZSNBOSQ-BQYQJAHWSA-N neratinib Chemical compound C=12C=C(NC\C=C\CN(C)C)C(OCC)=CC2=NC=C(C#N)C=1NC(C=C1Cl)=CC=C1OCC1=CC=CC=N1 ZNHPZUKZSNBOSQ-BQYQJAHWSA-N 0.000 claims 3
- 229960002087 pertuzumab Drugs 0.000 claims 3
- LHNIIDJUOCFXAP-UHFFFAOYSA-N pictrelisib Chemical compound C1CN(S(=O)(=O)C)CCN1CC1=CC2=NC(C=3C=4C=NNC=4C=CC=3)=NC(N3CCOCC3)=C2S1 LHNIIDJUOCFXAP-UHFFFAOYSA-N 0.000 claims 3
- 150000003384 small molecules Chemical class 0.000 claims 3
- CBPNZQVSJQDFBE-VBSVFFBFSA-N temsirolimus Chemical compound C1C[C@@H](OC(=O)C(C)(CO)CO)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)C(C)=C[C@@H](C)C(=O)C1 CBPNZQVSJQDFBE-VBSVFFBFSA-N 0.000 claims 3
- 101100067974 Arabidopsis thaliana POP2 gene Proteins 0.000 claims 2
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims 2
- 101100118549 Homo sapiens EGFR gene Proteins 0.000 claims 2
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 claims 2
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 claims 2
- 101100123851 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) HER1 gene Proteins 0.000 claims 2
- SBPBAQFWLVIOKP-UHFFFAOYSA-N chlorpyrifos Chemical compound CCOP(=S)(OCC)OC1=NC(Cl)=C(Cl)C=C1Cl SBPBAQFWLVIOKP-UHFFFAOYSA-N 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 229960000235 temsirolimus Drugs 0.000 claims 2
- QFJCIRLUMZQUOT-UHFFFAOYSA-N temsirolimus Natural products C1CC(O)C(OC)CC1CC(C)C1OC(=O)C2CCCCN2C(=O)C(=O)C(O)(O2)C(C)CCC2CC(OC)C(C)=CC=CC=CC(C)CC(C)C(=O)C(OC)C(O)C(C)=CC(C)C(=O)C1 QFJCIRLUMZQUOT-UHFFFAOYSA-N 0.000 claims 2
- STQGQHZAVUOBTE-UHFFFAOYSA-N 7-Cyan-hept-2t-en-4,6-diinsaeure Natural products C1=2C(O)=C3C(=O)C=4C(OC)=CC=CC=4C(=O)C3=C(O)C=2CC(O)(C(C)=O)CC1OC1CC(N)C(O)C(C)O1 STQGQHZAVUOBTE-UHFFFAOYSA-N 0.000 claims 1
- WEAHRLBPCANXCN-UHFFFAOYSA-N Daunomycin Natural products CCC1(O)CC(OC2CC(N)C(O)C(C)O2)c3cc4C(=O)c5c(OC)cccc5C(=O)c4c(O)c3C1 WEAHRLBPCANXCN-UHFFFAOYSA-N 0.000 claims 1
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 102000048238 Neuregulin-1 Human genes 0.000 claims 1
- 108090000556 Neuregulin-1 Proteins 0.000 claims 1
- 229930012538 Paclitaxel Natural products 0.000 claims 1
- JXLYSJRDGCGARV-WWYNWVTFSA-N Vinblastine Natural products O=C(O[C@H]1[C@](O)(C(=O)OC)[C@@H]2N(C)c3c(cc(c(OC)c3)[C@]3(C(=O)OC)c4[nH]c5c(c4CCN4C[C@](O)(CC)C[C@H](C3)C4)cccc5)[C@@]32[C@H]2[C@@]1(CC)C=CCN2CC3)C JXLYSJRDGCGARV-WWYNWVTFSA-N 0.000 claims 1
- 229940009456 adriamycin Drugs 0.000 claims 1
- 229940042992 afinitor Drugs 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 claims 1
- 229960004316 cisplatin Drugs 0.000 claims 1
- STQGQHZAVUOBTE-VGBVRHCVSA-N daunorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(C)=O)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 STQGQHZAVUOBTE-VGBVRHCVSA-N 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- VJJPUSNTGOMMGY-MRVIYFEKSA-N etoposide Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@H](C)OC[C@H]4O3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 VJJPUSNTGOMMGY-MRVIYFEKSA-N 0.000 claims 1
- 229960005420 etoposide Drugs 0.000 claims 1
- SDUQYLNIPVEERB-QPPQHZFASA-N gemcitabine Chemical compound O=C1N=C(N)C=CN1[C@H]1C(F)(F)[C@H](O)[C@@H](CO)O1 SDUQYLNIPVEERB-QPPQHZFASA-N 0.000 claims 1
- 229960005277 gemcitabine Drugs 0.000 claims 1
- 229960003685 imatinib mesylate Drugs 0.000 claims 1
- YLMAHDNUQAMNNX-UHFFFAOYSA-N imatinib methanesulfonate Chemical compound CS(O)(=O)=O.C1CN(C)CCN1CC1=CC=C(C(=O)NC=2C=C(NC=3N=C(C=CN=3)C=3C=NC=CC=3)C(C)=CC=2)C=C1 YLMAHDNUQAMNNX-UHFFFAOYSA-N 0.000 claims 1
- 238000007917 intracranial administration Methods 0.000 claims 1
- 238000007918 intramuscular administration Methods 0.000 claims 1
- 238000007912 intraperitoneal administration Methods 0.000 claims 1
- 238000007913 intrathecal administration Methods 0.000 claims 1
- 238000007914 intraventricular administration Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 229960000485 methotrexate Drugs 0.000 claims 1
- LBWFXVZLPYTWQI-IPOVEDGCSA-N n-[2-(diethylamino)ethyl]-5-[(z)-(5-fluoro-2-oxo-1h-indol-3-ylidene)methyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide;(2s)-2-hydroxybutanedioic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O.CCN(CC)CCNC(=O)C1=C(C)NC(\C=C/2C3=CC(F)=CC=C3NC\2=O)=C1C LBWFXVZLPYTWQI-IPOVEDGCSA-N 0.000 claims 1
- 229960001592 paclitaxel Drugs 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
- 229960002812 sunitinib malate Drugs 0.000 claims 1
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 1
- 229960003048 vinblastine Drugs 0.000 claims 1
- JXLYSJRDGCGARV-XQKSVPLYSA-N vincaleukoblastine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-XQKSVPLYSA-N 0.000 claims 1
- 229960004528 vincristine Drugs 0.000 claims 1
- OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 claims 1
- OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462025321P | 2014-07-16 | 2014-07-16 | |
| US62/025,321 | 2014-07-16 | ||
| PCT/US2015/040597 WO2016011167A1 (en) | 2014-07-16 | 2015-07-15 | Her3 inhibition in low-grade serous ovarian cancers |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020140568A Division JP7094329B2 (ja) | 2014-07-16 | 2020-08-24 | 低悪性度漿液性癌におけるｈｅｒ３阻害 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017520609A JP2017520609A (ja) | 2017-07-27 |
| JP2017520609A5 true JP2017520609A5 (cg-RX-API-DMAC7.html) | 2018-08-23 |
| JP6755235B2 JP6755235B2 (ja) | 2020-09-16 |
Family
ID=53783951
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017502620A Expired - Fee Related JP6755235B2 (ja) | 2014-07-16 | 2015-07-15 | 低悪性度漿液性癌におけるｈｅｒ３阻害 |
| JP2020140568A Active JP7094329B2 (ja) | 2014-07-16 | 2020-08-24 | 低悪性度漿液性癌におけるｈｅｒ３阻害 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020140568A Active JP7094329B2 (ja) | 2014-07-16 | 2020-08-24 | 低悪性度漿液性癌におけるｈｅｒ３阻害 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20170291956A1 (cg-RX-API-DMAC7.html) |
| EP (2) | EP3539990B1 (cg-RX-API-DMAC7.html) |
| JP (2) | JP6755235B2 (cg-RX-API-DMAC7.html) |
| CN (1) | CN107257691B (cg-RX-API-DMAC7.html) |
| ES (1) | ES2729202T3 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2016011167A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20170291956A1 (en) * | 2014-07-16 | 2017-10-12 | David Livingston | HER3 Inhibition in Low-grade Serous Ovarian Cancers |
| US10689459B2 (en) | 2014-12-12 | 2020-06-23 | Novartis Ag | Treatment of breast cancer brain metastases |
| WO2019185164A1 (en) | 2018-03-29 | 2019-10-03 | Hummingbird Bioscience Holdings Pte. Ltd. | Her3 antigen-binding molecules |
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| JP2010540459A (ja) * | 2007-09-24 | 2010-12-24 | トラガラ ファーマシューティカルズ，インク． | Ｃｏｘ‐２阻害薬及びｅｇｆｒ［ｅｒｂｂ１］とｈｅｒ‐２［ｅｒｂｂ２］の二重阻害薬を用いた癌を治療するための併用療法 |
| WO2009055730A1 (en) | 2007-10-25 | 2009-04-30 | Genentech, Inc. | Process for making thienopyrimidine compounds |
| PH12013500333A1 (en) * | 2010-08-20 | 2013-04-22 | Novartis Ag | Antibodies for epidermal growth factor receptor 3 (her3) |
| JP2014527035A (ja) * | 2011-06-30 | 2014-10-09 | メリマック ファーマシューティカルズ インコーポレーティッド | 婦人科悪性腫瘍を治療するためのパクリタキセルとの組み合わせの抗ＥｒｂＢ３抗体 |
| JP2015500829A (ja) | 2011-12-05 | 2015-01-08 | ノバルティス アーゲー | 上皮細胞増殖因子受容体３（ｈｅｒ３）のドメインｉｉに対するｈｅｒ３の抗体 |
| ES2758433T3 (es) | 2011-12-05 | 2020-05-05 | Novartis Ag | Anticuerpos contra el receptor 3 del factor de crecimiento epidérmico (HER3) |
| UY34488A (es) | 2011-12-05 | 2013-07-31 | Novartis Ag | Anticuerpos dirigidos al receptor de factor de crecimiento epidérmico 3 (her3) dirigidos contra el dominio iii y dominio iv del her3 |
| AU2014230945B2 (en) * | 2013-03-12 | 2019-07-11 | Ventana Medical Systems, Inc. | Proximity assay for in situ detection of targets |
| US20160038516A1 (en) * | 2013-03-15 | 2016-02-11 | Mone Zaidi Consulting, Inc. | Combination cancer therapy using bisphosphonates and anti-egfr agents |
| US20170291956A1 (en) * | 2014-07-16 | 2017-10-12 | David Livingston | HER3 Inhibition in Low-grade Serous Ovarian Cancers |
-
2015
- 2015-07-15 US US15/325,336 patent/US20170291956A1/en not_active Abandoned
- 2015-07-15 EP EP19155820.4A patent/EP3539990B1/en not_active Not-in-force
- 2015-07-15 CN CN201580046809.0A patent/CN107257691B/zh not_active Expired - Fee Related
- 2015-07-15 EP EP15747648.2A patent/EP3169708B1/en not_active Not-in-force
- 2015-07-15 JP JP2017502620A patent/JP6755235B2/ja not_active Expired - Fee Related
- 2015-07-15 WO PCT/US2015/040597 patent/WO2016011167A1/en not_active Ceased
- 2015-07-15 ES ES15747648T patent/ES2729202T3/es active Active
-
2020
- 2020-08-24 JP JP2020140568A patent/JP7094329B2/ja active Active
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