JP2017519801A5 - - Google Patents
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- Publication number
- JP2017519801A5 JP2017519801A5 JP2017500885A JP2017500885A JP2017519801A5 JP 2017519801 A5 JP2017519801 A5 JP 2017519801A5 JP 2017500885 A JP2017500885 A JP 2017500885A JP 2017500885 A JP2017500885 A JP 2017500885A JP 2017519801 A5 JP2017519801 A5 JP 2017519801A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- substituted
- alkyl
- compound
- alkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 125000000217 alkyl group Chemical group 0.000 claims 72
- 125000001424 substituent group Chemical group 0.000 claims 41
- 229910052736 halogen Inorganic materials 0.000 claims 39
- 150000001875 compounds Chemical class 0.000 claims 38
- 150000002367 halogens Chemical class 0.000 claims 37
- 125000003545 alkoxy group Chemical group 0.000 claims 28
- 125000001072 heteroaryl group Chemical group 0.000 claims 24
- 150000003839 salts Chemical class 0.000 claims 23
- 241000282465 Canis Species 0.000 claims 22
- 125000004414 alkyl thio group Chemical group 0.000 claims 21
- 125000004093 cyano group Chemical group *C#N 0.000 claims 18
- 125000006163 5-membered heteroaryl group Chemical group 0.000 claims 17
- 208000015181 infectious disease Diseases 0.000 claims 17
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 16
- 125000001188 haloalkyl group Chemical group 0.000 claims 15
- 201000006353 Filariasis Diseases 0.000 claims 14
- 229910052757 nitrogen Inorganic materials 0.000 claims 14
- 125000002102 aryl alkyloxo group Chemical group 0.000 claims 12
- 125000005647 linker group Chemical group 0.000 claims 11
- 125000004391 aryl sulfonyl group Chemical group 0.000 claims 10
- -1 arylalkylsulfanyl Chemical group 0.000 claims 8
- 125000004104 aryloxy group Chemical group 0.000 claims 8
- 125000003118 aryl group Chemical group 0.000 claims 7
- 125000004439 haloalkylsulfanyl group Chemical group 0.000 claims 7
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 7
- 125000003342 alkenyl group Chemical group 0.000 claims 6
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 6
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 claims 6
- 125000005163 aryl sulfanyl group Chemical group 0.000 claims 6
- 125000004429 atom Chemical group 0.000 claims 5
- 125000004644 alkyl sulfinyl group Chemical group 0.000 claims 4
- 125000005114 heteroarylalkoxy group Chemical group 0.000 claims 4
- 125000005553 heteroaryloxy group Chemical group 0.000 claims 4
- 125000003386 piperidinyl group Chemical group 0.000 claims 4
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 3
- 125000004438 haloalkoxy group Chemical group 0.000 claims 3
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 3
- 125000004070 6 membered heterocyclic group Chemical group 0.000 claims 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- 239000004215 Carbon black (E152) Substances 0.000 claims 2
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 2
- 125000000304 alkynyl group Chemical group 0.000 claims 2
- 125000005135 aryl sulfinyl group Chemical group 0.000 claims 2
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 2
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- 125000005150 heteroarylsulfinyl group Chemical group 0.000 claims 2
- 125000005143 heteroarylsulfonyl group Chemical group 0.000 claims 2
- 229930195733 hydrocarbon Natural products 0.000 claims 2
- 125000004193 piperazinyl group Chemical group 0.000 claims 2
- 125000003396 thiol group Chemical group [H]S* 0.000 claims 2
- 125000002373 5 membered heterocyclic group Chemical group 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 125000004366 heterocycloalkenyl group Chemical group 0.000 claims 1
- 150000002430 hydrocarbons Chemical class 0.000 claims 1
- 125000001183 hydrocarbyl group Chemical group 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14176737.6 | 2014-07-11 | ||
| EP14176737 | 2014-07-11 | ||
| PCT/EP2015/065870 WO2016005577A1 (en) | 2014-07-11 | 2015-07-10 | Use of anthelmintic agents against dirofilaria immitis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017519801A JP2017519801A (ja) | 2017-07-20 |
| JP2017519801A5 true JP2017519801A5 (cg-RX-API-DMAC7.html) | 2018-07-26 |
Family
ID=51167759
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017500885A Withdrawn JP2017519801A (ja) | 2014-07-11 | 2015-07-10 | 犬糸状虫に対する駆虫薬の使用 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20170196854A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3166605A1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2017519801A (cg-RX-API-DMAC7.html) |
| CN (1) | CN106470683A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2015286635A1 (cg-RX-API-DMAC7.html) |
| BR (1) | BR112017000520A2 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2016005577A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2788856T3 (es) | 2017-03-20 | 2020-10-23 | Forma Therapeutics Inc | Composiciones de pirrolopirrol como activadores de quinasa de piruvato (PKR) |
| JOP20190223A1 (ar) | 2017-04-01 | 2019-09-26 | Novartis Ag | عملية لتحضير حمض 1-(4- ميثان سلفونيل -2- تراي فلورو ميثيل - بنزيل)-2- ميثيل -1h- بيرولو [2، 3-b] بيريدين -3- يل- أسيتيك |
| WO2020061378A1 (en) | 2018-09-19 | 2020-03-26 | Forma Therapeutics, Inc. | Treating sickle cell disease with a pyruvate kinase r activating compound |
| ES2989438T3 (es) | 2018-09-19 | 2024-11-26 | Novo Nordisk Healthcare Ag | Activación de la piruvato cinasa R |
| TWI767148B (zh) | 2018-10-10 | 2022-06-11 | 美商弗瑪治療公司 | 抑制脂肪酸合成酶(fasn) |
| AU2019387370A1 (en) | 2018-11-30 | 2021-06-10 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
| JP7693558B2 (ja) * | 2019-06-07 | 2025-06-17 | エランコ・ティアゲゾンタイト・アーゲー | 内部寄生虫を治療するための二環式誘導体 |
| MA57202B1 (fr) | 2019-09-19 | 2025-09-30 | Novo Nordisk Health Care Ag | Compositions d'activation de la pyruvate kinase r (pkr) |
| EP4110336A4 (en) * | 2020-02-28 | 2024-06-05 | Auburn University | SIGNATURES OF DIROFILARIA VOLATILE ORGANIC COMPOUNDS AND THEIR USES |
| WO2021175155A1 (zh) * | 2020-03-06 | 2021-09-10 | 广州再极医药科技有限公司 | 噻吩并嘧啶类衍生物及其制备方法 |
| US12128035B2 (en) | 2021-03-19 | 2024-10-29 | Novo Nordisk Health Care Ag | Activating pyruvate kinase R |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200938203A (en) * | 2007-12-17 | 2009-09-16 | Intervet Int Bv | Anthelmintic agents and their use |
| TW201041868A (en) * | 2009-03-20 | 2010-12-01 | Intervet Int Bv | Anthelmintic agents and their use |
| TW201111358A (en) * | 2009-06-18 | 2011-04-01 | Intervet Int Bv | Anthelmintic agents and their use |
| EP2468096A1 (en) * | 2010-12-21 | 2012-06-27 | Intervet International BV | Anthelmintic combinations |
| HRP20181448T1 (hr) * | 2012-11-20 | 2018-11-02 | Merial, Inc. | Antihelmintski spojevi i sastavi te postupak za njihovu uporabu |
-
2015
- 2015-07-10 EP EP15738607.9A patent/EP3166605A1/en not_active Withdrawn
- 2015-07-10 WO PCT/EP2015/065870 patent/WO2016005577A1/en not_active Ceased
- 2015-07-10 JP JP2017500885A patent/JP2017519801A/ja not_active Withdrawn
- 2015-07-10 AU AU2015286635A patent/AU2015286635A1/en not_active Abandoned
- 2015-07-10 CN CN201580037488.8A patent/CN106470683A/zh active Pending
- 2015-07-10 BR BR112017000520A patent/BR112017000520A2/pt not_active Application Discontinuation
- 2015-07-10 US US15/324,896 patent/US20170196854A1/en not_active Abandoned
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