JP2017519762A5 - - Google Patents
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- Publication number
- JP2017519762A5 JP2017519762A5 JP2016573549A JP2016573549A JP2017519762A5 JP 2017519762 A5 JP2017519762 A5 JP 2017519762A5 JP 2016573549 A JP2016573549 A JP 2016573549A JP 2016573549 A JP2016573549 A JP 2016573549A JP 2017519762 A5 JP2017519762 A5 JP 2017519762A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- polypeptide
- human
- composition according
- vwf
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 22
- 229920001184 polypeptide Polymers 0.000 claims 19
- 102000004196 processed proteins & peptides Human genes 0.000 claims 19
- 108090000765 processed proteins & peptides Proteins 0.000 claims 19
- 108010047303 von Willebrand Factor Proteins 0.000 claims 13
- 102100036537 von Willebrand factor Human genes 0.000 claims 13
- 229960001134 von willebrand factor Drugs 0.000 claims 13
- 230000000694 effects Effects 0.000 claims 10
- 102000043853 ADAMTS13 Human genes 0.000 claims 9
- 108091005670 ADAMTS13 Proteins 0.000 claims 9
- 230000008816 organ damage Effects 0.000 claims 9
- 125000003275 alpha amino acid group Chemical group 0.000 claims 5
- 230000006378 damage Effects 0.000 claims 5
- 201000010099 disease Diseases 0.000 claims 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 5
- 230000000302 ischemic effect Effects 0.000 claims 5
- 239000003550 marker Substances 0.000 claims 4
- 108060003951 Immunoglobulin Proteins 0.000 claims 3
- 102000018358 immunoglobulin Human genes 0.000 claims 3
- 230000001154 acute effect Effects 0.000 claims 2
- 102000006395 Globulins Human genes 0.000 claims 1
- 108010044091 Globulins Proteins 0.000 claims 1
- 101000798281 Homo sapiens A disintegrin and metalloproteinase with thrombospondin motifs 13 Proteins 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 102000057210 human ADAMTS13 Human genes 0.000 claims 1
- 230000036039 immunity Effects 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL2013007 | 2014-06-16 | ||
| NL2013007A NL2013007B1 (en) | 2014-06-16 | 2014-06-16 | Methods of treating TTP with immunoglobulin single variable domains and uses thereof. |
| US201462030817P | 2014-07-30 | 2014-07-30 | |
| US62/030,817 | 2014-07-30 | ||
| PCT/EP2015/063493 WO2015193326A1 (en) | 2014-06-16 | 2015-06-16 | Methods of treating ttp with immunoglobulin single variable domains and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020014229A Division JP7105260B2 (ja) | 2014-06-16 | 2020-01-30 | 免疫グロブリン単一可変ドメインでｔｔｐを処置する方法、およびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017519762A JP2017519762A (ja) | 2017-07-20 |
| JP2017519762A5 true JP2017519762A5 (cg-RX-API-DMAC7.html) | 2019-01-17 |
| JP6688746B2 JP6688746B2 (ja) | 2020-04-28 |
Family
ID=51541255
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016573549A Active JP6688746B2 (ja) | 2014-06-16 | 2015-06-16 | 免疫グロブリン単一可変ドメインでｔｔｐを処置する方法、およびその使用 |
| JP2020014229A Active JP7105260B2 (ja) | 2014-06-16 | 2020-01-30 | 免疫グロブリン単一可変ドメインでｔｔｐを処置する方法、およびその使用 |
| JP2022110921A Pending JP2022160431A (ja) | 2014-06-16 | 2022-07-11 | 免疫グロブリン単一可変ドメインでｔｔｐを処置する方法、およびその使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020014229A Active JP7105260B2 (ja) | 2014-06-16 | 2020-01-30 | 免疫グロブリン単一可変ドメインでｔｔｐを処置する方法、およびその使用 |
| JP2022110921A Pending JP2022160431A (ja) | 2014-06-16 | 2022-07-11 | 免疫グロブリン単一可変ドメインでｔｔｐを処置する方法、およびその使用 |
Country Status (15)
| Country | Link |
|---|---|
| US (5) | US10858445B2 (cg-RX-API-DMAC7.html) |
| EP (6) | EP3335723B1 (cg-RX-API-DMAC7.html) |
| JP (3) | JP6688746B2 (cg-RX-API-DMAC7.html) |
| KR (2) | KR102568585B1 (cg-RX-API-DMAC7.html) |
| CN (1) | CN106559985A (cg-RX-API-DMAC7.html) |
| AU (2) | AU2015276237B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2952103A1 (cg-RX-API-DMAC7.html) |
| ES (5) | ES2881331T3 (cg-RX-API-DMAC7.html) |
| IL (1) | IL249540B (cg-RX-API-DMAC7.html) |
| NL (1) | NL2013007B1 (cg-RX-API-DMAC7.html) |
| PL (5) | PL3335723T3 (cg-RX-API-DMAC7.html) |
| PT (5) | PT3366305T (cg-RX-API-DMAC7.html) |
| RU (1) | RU2704444C2 (cg-RX-API-DMAC7.html) |
| SG (2) | SG10201811109PA (cg-RX-API-DMAC7.html) |
| WO (1) | WO2015193326A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL2013007B1 (en) | 2014-06-16 | 2016-07-05 | Ablynx Nv | Methods of treating TTP with immunoglobulin single variable domains and uses thereof. |
| CN107340225B (zh) * | 2017-07-13 | 2019-07-05 | 徐州医科大学 | 一种基于流式细胞术检测血小板受体GPIba胞外段酶切的方法 |
| CA3089211A1 (en) * | 2018-02-06 | 2019-08-15 | Ablynx Nv | Methods of treating initial episode of ttp with immunoglobulin single variable domains |
| CA3201986A1 (en) * | 2020-11-18 | 2022-05-27 | Green Cross Corporation | Adamts13 variant having increased escaping rate or activity against autoantibody |
| EP4402165A1 (en) | 2021-09-17 | 2024-07-24 | The United States of America, as represented by the Secretary, Department of Health and Human Services | Synthetic humanized llama nanobody library and use thereof to identify sars-cov-2 neutralizing antibodies |
| US20240409666A1 (en) * | 2021-12-10 | 2024-12-12 | Renhao Li | Polypeptides That Bind to von Willebrand Factor (VWF) A1 Domain or an Autoinhibitory Module, Variants, and Uses Thereof |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB335768A (en) | 1929-10-24 | 1930-10-02 | Jacoviac Maurice | Improvements in protecting devices for gramophone disc records |
| US4399216A (en) | 1980-02-25 | 1983-08-16 | The Trustees Of Columbia University | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
| US4634665A (en) | 1980-02-25 | 1987-01-06 | The Trustees Of Columbia University In The City Of New York | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
| US5179017A (en) | 1980-02-25 | 1993-01-12 | The Trustees Of Columbia University In The City Of New York | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
| US5043429B1 (en) | 1987-05-01 | 1997-10-14 | Scripps Research Inst | Protein fragments containing factor VIII binding domain of von willebrand factor |
| ATE102631T1 (de) | 1988-11-11 | 1994-03-15 | Medical Res Council | Klonierung von immunglobulin sequenzen aus den variabelen domaenen. |
| PT1589107E (pt) | 1992-08-21 | 2010-03-29 | Univ Bruxelles | Imunoglobulinas desprovidas de cadeias leves |
| US5827690A (en) | 1993-12-20 | 1998-10-27 | Genzyme Transgenics Corporatiion | Transgenic production of antibodies in milk |
| US6329516B1 (en) | 1997-04-28 | 2001-12-11 | Fmc Corporation | Lepidopteran GABA-gated chloride channels |
| CA2361678A1 (en) | 1999-02-05 | 2000-08-10 | Rijksuniversiteit Leiden | Method of modulating metabolite biosynthesis in recombinant cells |
| AU6322900A (en) | 1999-08-02 | 2001-02-19 | Keygene N.V. | Method for generating resistance against cgmmv in plants, genetic constructs for use in said method, and cgmmv-resistant plants obtained via said method |
| US20060073141A1 (en) | 2001-06-28 | 2006-04-06 | Domantis Limited | Compositions and methods for treating inflammatory disorders |
| EP1527346B1 (en) | 2002-08-07 | 2011-06-08 | Ablynx N.V. | Modulation of platelet adhesion based on the surface exposed beta-switch loop of platelet glycoprotein ib-alpha |
| WO2004037999A2 (en) | 2002-10-23 | 2004-05-06 | Ludwig Institute For Cancer Research | A34 and a33-like 3 dna, proteins, antibodies thereto and methods of treatment using same |
| CN100439400C (zh) | 2003-01-10 | 2008-12-03 | 埃博灵克斯股份有限公司 | 治疗性多肽,其同源物、其片段及其在调节血小板介导的聚集方面的应用 |
| RU2524129C2 (ru) | 2003-01-10 | 2014-07-27 | Аблинкс Н.В. | Терапевтические полипептиды, их гомологи, их фрагменты и их применение для модуляции агрегации, опосредованной тромбоцитами |
| US7461263B2 (en) | 2003-01-23 | 2008-12-02 | Unspam, Llc. | Method and apparatus for a non-revealing do-not-contact list system |
| JP2007521234A (ja) | 2003-08-12 | 2007-08-02 | ウィリアム エム ヤーブロー | 尋常性ざ瘡の治療薬及び使用方法 |
| US7270976B2 (en) * | 2004-07-19 | 2007-09-18 | American Diagnostica, Inc. | Methods for measuring ADAMTS13 activity and protein on platelets and in plasma |
| US7563443B2 (en) | 2004-09-17 | 2009-07-21 | Domantis Limited | Monovalent anti-CD40L antibody polypeptides and compositions thereof |
| WO2006040153A2 (en) | 2004-10-13 | 2006-04-20 | Ablynx N.V. | Single domain camelide anti -amyloid beta antibodies and polypeptides comprising the same for the treatment and diagnosis of degenarative neural diseases such as alzheimer's disease |
| PT1836500E (pt) | 2005-01-14 | 2010-09-28 | Ablynx Nv | Métodos e ensaios para distinguir diferentes formas de doenças e perturbações caracterizadas por trombocitopenia e/ou por interacção espontânea entre o factor de von willebrand (vwf) e plaquetas |
| BRPI0609797B8 (pt) * | 2005-05-20 | 2021-05-25 | Ablynx Nv | nanocorpos melhorados para o tratamento de desordens mediadas por agregação |
| US8629244B2 (en) | 2006-08-18 | 2014-01-14 | Ablynx N.V. | Interleukin-6 receptor binding polypeptides |
| EP2121757A2 (en) | 2007-02-21 | 2009-11-25 | Ablynx N.V. | Amino acid sequences directed against vascular endothelial growth factor and polypeptides comprising the same for the treatment of conditions and diseases characterized by excessive and/or pathological angiogenesis or neovascularization |
| CA2687903C (en) | 2007-05-24 | 2016-09-13 | Ablynx N.V. | Amino acid sequences directed against rank-l and polypeptides comprising the same for the treatment of bone diseases and disorders |
| CN101977654A (zh) | 2008-03-21 | 2011-02-16 | 埃博灵克斯股份有限公司 | 冯威勒布兰特因子特异性结合物及其应用方法 |
| KR101593285B1 (ko) | 2008-10-29 | 2016-02-11 | 아블린쓰 엔.브이. | 단일 도메인 항원 결합 분자의 제형 |
| MX2011004558A (es) | 2008-10-29 | 2011-06-01 | Wyeth Llc | Procedimientos para la purificacion de moleculas de union a antigeno de un unico dominio. |
| EP2506874A1 (en) | 2009-12-01 | 2012-10-10 | Ablynx N.V. | Von willebrand factor specific binding agents and uses thereof |
| EP4116325A1 (en) * | 2010-11-05 | 2023-01-11 | Novartis AG | Methods of treating rheumatoid arthritis using il-17 antagonists |
| MX350582B (es) | 2011-06-10 | 2017-09-11 | Baxalta Inc | Tratamiento de trastornos de la coagulacion mediante la administracion del factor de von willebrand (vwf) recombinante. |
| KR102162413B1 (ko) | 2011-08-17 | 2020-10-07 | 글락소 그룹 리미티드 | 변형된 단백질 및 펩티드 |
| NL2013007B1 (en) | 2014-06-16 | 2016-07-05 | Ablynx Nv | Methods of treating TTP with immunoglobulin single variable domains and uses thereof. |
| CA3089211A1 (en) | 2018-02-06 | 2019-08-15 | Ablynx Nv | Methods of treating initial episode of ttp with immunoglobulin single variable domains |
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2014
- 2014-06-16 NL NL2013007A patent/NL2013007B1/en active
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2015
- 2015-06-16 PT PT181536715T patent/PT3366305T/pt unknown
- 2015-06-16 PT PT157298290T patent/PT3154569T/pt unknown
- 2015-06-16 EP EP18153673.1A patent/EP3335723B1/en active Active
- 2015-06-16 EP EP18153671.5A patent/EP3366305B1/en active Active
- 2015-06-16 SG SG10201811109PA patent/SG10201811109PA/en unknown
- 2015-06-16 ES ES15729829T patent/ES2881331T3/es active Active
- 2015-06-16 AU AU2015276237A patent/AU2015276237B2/en active Active
- 2015-06-16 SG SG11201610488QA patent/SG11201610488QA/en unknown
- 2015-06-16 JP JP2016573549A patent/JP6688746B2/ja active Active
- 2015-06-16 PL PL18153673.1T patent/PL3335723T3/pl unknown
- 2015-06-16 KR KR1020227012546A patent/KR102568585B1/ko active Active
- 2015-06-16 EP EP18153674.9A patent/EP3335724B1/en active Active
- 2015-06-16 PL PL18153674.9T patent/PL3335724T3/pl unknown
- 2015-06-16 EP EP15729829.0A patent/EP3154569B1/en active Active
- 2015-06-16 RU RU2017100077A patent/RU2704444C2/ru active
- 2015-06-16 US US15/319,467 patent/US10858445B2/en active Active
- 2015-06-16 ES ES18153671T patent/ES2843642T3/es active Active
- 2015-06-16 CN CN201580040020.4A patent/CN106559985A/zh active Pending
- 2015-06-16 WO PCT/EP2015/063493 patent/WO2015193326A1/en not_active Ceased
- 2015-06-16 KR KR1020177001152A patent/KR102403388B1/ko active Active
- 2015-06-16 PL PL18153671T patent/PL3366305T3/pl unknown
- 2015-06-16 PT PT181536764T patent/PT3332800T/pt unknown
- 2015-06-16 ES ES18153676T patent/ES2831865T3/es active Active
- 2015-06-16 ES ES18153673T patent/ES2915473T3/es active Active
- 2015-06-16 EP EP18153676.4A patent/EP3332800B1/en active Active
- 2015-06-16 PL PL15729829T patent/PL3154569T3/pl unknown
- 2015-06-16 EP EP22172948.6A patent/EP4059513A1/en not_active Withdrawn
- 2015-06-16 ES ES18153674T patent/ES2924199T3/es active Active
- 2015-06-16 PT PT181536749T patent/PT3335724T/pt unknown
- 2015-06-16 PL PL18153676T patent/PL3332800T3/pl unknown
- 2015-06-16 CA CA2952103A patent/CA2952103A1/en not_active Abandoned
- 2015-06-16 PT PT181536731T patent/PT3335723T/pt unknown
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2016
- 2016-12-13 IL IL249540A patent/IL249540B/en unknown
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2018
- 2018-01-26 US US15/880,978 patent/US12269893B2/en active Active
- 2018-01-26 US US15/881,055 patent/US20180155443A1/en not_active Abandoned
- 2018-01-26 US US15/880,870 patent/US20180155440A1/en not_active Abandoned
- 2018-01-26 US US15/881,003 patent/US10919980B2/en active Active
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2020
- 2020-01-30 JP JP2020014229A patent/JP7105260B2/ja active Active
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2021
- 2021-05-03 AU AU2021202747A patent/AU2021202747B2/en active Active
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2022
- 2022-07-11 JP JP2022110921A patent/JP2022160431A/ja active Pending