JP2017518358A5 - - Google Patents
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- Publication number
- JP2017518358A5 JP2017518358A5 JP2016574184A JP2016574184A JP2017518358A5 JP 2017518358 A5 JP2017518358 A5 JP 2017518358A5 JP 2016574184 A JP2016574184 A JP 2016574184A JP 2016574184 A JP2016574184 A JP 2016574184A JP 2017518358 A5 JP2017518358 A5 JP 2017518358A5
- Authority
- JP
- Japan
- Prior art keywords
- inden
- oxoethyl
- oxazol
- morpholin
- methylpropyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 239000003814 drug Substances 0.000 claims 11
- 229940079593 drugs Drugs 0.000 claims 9
- PLVGDGRBPMVYPB-FDUHJNRSSA-N (3R,6R)-6-[(2S)-butan-2-yl]-3-(2,3-dihydro-1H-inden-2-yl)-1-[(1R)-1-(2-methyl-1,3-oxazol-4-yl)-2-morpholin-4-yl-2-oxoethyl]piperazine-2,5-dione Chemical compound O=C([C@H](N1[C@@H](C(N[C@@H](C1=O)C1CC2=CC=CC=C2C1)=O)[C@@H](C)CC)C=1N=C(C)OC=1)N1CCOCC1 PLVGDGRBPMVYPB-FDUHJNRSSA-N 0.000 claims 6
- 208000006399 Premature Obstetric Labor Diseases 0.000 claims 5
- -1 2,3-dihydro-1H-inden-2-yl Chemical group 0.000 claims 4
- 206010035633 Multiple pregnancy Diseases 0.000 claims 4
- 239000003795 chemical substances by application Substances 0.000 claims 4
- 206010028243 Multiple pregnancy Diseases 0.000 claims 3
- 239000012530 fluid Substances 0.000 claims 3
- 206010036600 Premature labour Diseases 0.000 claims 2
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims 2
- 210000003679 Cervix Uteri Anatomy 0.000 claims 1
- 102000016359 Fibronectins Human genes 0.000 claims 1
- 108010067306 Fibronectins Proteins 0.000 claims 1
- 208000005107 Premature Birth Diseases 0.000 claims 1
- 206010036590 Premature baby Diseases 0.000 claims 1
- 230000001605 fetal Effects 0.000 claims 1
- 230000037320 fibronectin Effects 0.000 claims 1
- 238000001802 infusion Methods 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 230000036470 plasma concentration Effects 0.000 claims 1
- 201000007532 polyhydramnios Diseases 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 238000001356 surgical procedure Methods 0.000 claims 1
Claims (12)
- 多胎妊娠または羊水過多症を有するヒト女性対象における早期分娩の治療のための薬剤であって、(3R,6R)−3−(2,3−ジヒドロ−1H−インデン−2−イル)−1−[(1R)−1−(2−メチル−1,3−オキサゾール−4−イル)−2−(モルホリン−4−イル}−2−オキソエチル]−6−[(1S)−1−メチルプロピル]−2,5−ピペラジンジオンを含んでなる、薬剤。
- 前記ヒト女性対象が多胎妊娠している、請求項1に記載の薬剤。
- 前記ヒト女性対象が羊水過多症を有する、請求項1に記載の薬剤。
- (3R,6R)−3−(2,3−ジヒドロ−1H−インデン−2−イル)−1−[(1R)−1−(2−メチル−1,3−オキサゾール−4−イル)−2−(モルホリン−4−イル}−2−オキソエチル]−6−[(1S)−1−メチルプロピル]−2,5−ピペラジンジオンが非経口投与される、請求項1〜3のいずれか一項に記載の薬剤。
- (3R,6R)−3−(2,3−ジヒドロ−1H−インデン−2−イル)−1−[(1R)−1−(2−メチル−1,3−オキサゾール−4−イル)−2−(モルホリン−4−イル}−2−オキソエチル]−6−[(1S)−1−メチルプロピル]−2,5−ピペラジンジオンが静脈内注入によって5〜400ng/mLの間のレトシバンの血漿濃度を生成するのに必要な用量で投与される、請求項4に記載の薬剤。
- (3R,6R)−3−(2,3−ジヒドロ−1H−インデン−2−イル)−1−[(1R)−1−(2−メチル−1,3−オキサゾール−4−イル)−2−(モルホリン−4−イル}−2−オキソエチル]−6−[(1S)−1−メチルプロピル]−2,5−ピペラジンジオンが経口投与される、請求項1〜3のいずれか一項に記載の薬剤。
- (3R,6R)−3−(2,3−ジヒドロ−1H−インデン−2−イル)−1−[(1R)−1−(2−メチル−1,3−オキサゾール−4−イル)−2−(モルホリン−4−イル}−2−オキソエチル]−6−[(1S)−1−メチルプロピル]−2,5−ピペラジンジオンが200〜500mg/日の間の用量で投与される、請求項6に記載の薬剤。
- 早期分娩についての少なくとも1つの認識されている危険因子を有するヒト女性対象における早期分娩の予防のための薬剤であって、(3R,6R)−3−(2,3−ジヒドロ−1H−インデン−2−イル)−1−[(1R)−1−(2−メチル−1,3−オキサゾール−4−イル)−2−(モルホリン−4−イル}−2−オキソエチル]−6−[(1S)−1−メチルプロピル]−2,5−ピペラジンジオンを含んでなる、薬剤。
- 前記早期分娩についての少なくとも1つの認識されている危険因子が、短い子宮頸管、膣スワブによる胎児性フィブロネクチンの存在、既往早産、既往子宮頸管手術、子宮の異常、羊水過多症および多胎妊娠から選択される、請求項8に記載の薬剤。
- 前記早期分娩についての少なくとも1つの認識されている危険因子が、羊水過多症または多胎妊娠である、請求項9に記載の薬剤。
- (3R,6R)−3−(2,3−ジヒドロ−1H−インデン−2−イル)−1−[(1R)−1−(2−メチル−1,3−オキサゾール−4−イル)−2−(モルホリン−4−イル}−2−オキソエチル]−6−[(1S)−1−メチルプロピル]−2,5−ピペラジンジオンが経口投与される、請求項8〜10のいずれか一項に記載の薬剤。
- (3R,6R)−3−(2,3−ジヒドロ−1H−インデン−2−イル)−1−[(1R)−1−(2−メチル−1,3−オキサゾール−4−イル)−2−(モルホリン−4−イル}−2−オキソエチル]−6−[(1S)−1−メチルプロピル]−2,5−ピペラジンジオンが200〜500mg/日の間の用量で投与される、請求項11に記載の薬剤。
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/EP2014/062602 WO2015192878A1 (en) | 2014-06-16 | 2014-06-16 | Retosiban for the treatment of pre-term labour |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2017518358A JP2017518358A (ja) | 2017-07-06 |
JP2017518358A5 true JP2017518358A5 (ja) | 2017-08-17 |
Family
ID=51014274
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2016574184A Pending JP2017518358A (ja) | 2014-06-16 | 2014-06-16 | 早期分娩の治療のためのレトシバン |
Country Status (10)
Country | Link |
---|---|
US (2) | US20170119779A1 (ja) |
EP (1) | EP3154548A1 (ja) |
JP (1) | JP2017518358A (ja) |
KR (1) | KR20170029507A (ja) |
CN (1) | CN106999497A (ja) |
AU (2) | AU2014397706A1 (ja) |
BR (1) | BR112016029661A2 (ja) |
CA (1) | CA2952585A1 (ja) |
RU (1) | RU2017100906A (ja) |
WO (1) | WO2015192878A1 (ja) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SG11201804594YA (en) * | 2016-01-04 | 2018-06-28 | Merck Serono Sa | L-valinate of hydroxypropylthiazolidine carboxamide derivative and salt form, crystal polymorph thereof |
CN109790133A (zh) | 2016-01-04 | 2019-05-21 | 奥布赛瓦股份公司 | 羟丙基噻唑烷羧酰胺衍生物的α-氨基酯及其盐形式、晶体多形体 |
US11534428B1 (en) | 2018-05-16 | 2022-12-27 | Xoma (Us) Llc | Compositions and methods for delaying the incidence of labor |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0314738D0 (en) | 2003-06-24 | 2003-07-30 | Glaxo Group Ltd | Novel compounds |
-
2014
- 2014-06-16 JP JP2016574184A patent/JP2017518358A/ja active Pending
- 2014-06-16 US US15/319,575 patent/US20170119779A1/en not_active Abandoned
- 2014-06-16 RU RU2017100906A patent/RU2017100906A/ru not_active Application Discontinuation
- 2014-06-16 CA CA2952585A patent/CA2952585A1/en not_active Abandoned
- 2014-06-16 KR KR1020177000827A patent/KR20170029507A/ko not_active Application Discontinuation
- 2014-06-16 CN CN201480081034.6A patent/CN106999497A/zh active Pending
- 2014-06-16 AU AU2014397706A patent/AU2014397706A1/en not_active Abandoned
- 2014-06-16 WO PCT/EP2014/062602 patent/WO2015192878A1/en active Application Filing
- 2014-06-16 BR BR112016029661A patent/BR112016029661A2/pt not_active Application Discontinuation
- 2014-06-16 EP EP14732852.0A patent/EP3154548A1/en not_active Withdrawn
-
2018
- 2018-02-08 US US15/892,057 patent/US20180161338A1/en not_active Abandoned
- 2018-06-20 AU AU2018204436A patent/AU2018204436A1/en not_active Abandoned
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