JP2017515839A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2017515839A5 JP2017515839A5 JP2016567385A JP2016567385A JP2017515839A5 JP 2017515839 A5 JP2017515839 A5 JP 2017515839A5 JP 2016567385 A JP2016567385 A JP 2016567385A JP 2016567385 A JP2016567385 A JP 2016567385A JP 2017515839 A5 JP2017515839 A5 JP 2017515839A5
- Authority
- JP
- Japan
- Prior art keywords
- formulation
- brain
- nanoparticle
- polymer
- hydrophilic polymer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461991920P | 2014-05-12 | 2014-05-12 | |
| US201461991898P | 2014-05-12 | 2014-05-12 | |
| US61/991,898 | 2014-05-12 | ||
| US61/991,920 | 2014-05-12 | ||
| US201462001994P | 2014-05-22 | 2014-05-22 | |
| US62/001,994 | 2014-05-22 | ||
| PCT/US2015/030381 WO2015175539A1 (en) | 2014-05-12 | 2015-05-12 | Engineering synthetic brain penetrating gene vectors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020116339A Division JP2020172534A (ja) | 2014-05-12 | 2020-07-06 | 合成脳浸透遺伝子ベクターの操作 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017515839A JP2017515839A (ja) | 2017-06-15 |
| JP2017515839A5 true JP2017515839A5 (https=) | 2018-04-26 |
| JP6763780B2 JP6763780B2 (ja) | 2020-09-30 |
Family
ID=53264811
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016567385A Active JP6763780B2 (ja) | 2014-05-12 | 2015-05-12 | 合成脳浸透遺伝子ベクターの操作 |
| JP2020116339A Pending JP2020172534A (ja) | 2014-05-12 | 2020-07-06 | 合成脳浸透遺伝子ベクターの操作 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020116339A Pending JP2020172534A (ja) | 2014-05-12 | 2020-07-06 | 合成脳浸透遺伝子ベクターの操作 |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US9937270B2 (https=) |
| EP (1) | EP3142704A1 (https=) |
| JP (2) | JP6763780B2 (https=) |
| AU (1) | AU2015259362B2 (https=) |
| CA (1) | CA2948844C (https=) |
| WO (1) | WO2015175539A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011106702A2 (en) | 2010-02-25 | 2011-09-01 | The Johns Hopkins University | Sustained delivery of therapeutic agents to an eye compartment |
| US10632080B2 (en) * | 2015-09-11 | 2020-04-28 | The Johns Hopkins University | Compositions and methods to improve nanoparticle distribution within the brain interstitium |
| US12496279B2 (en) | 2019-04-11 | 2025-12-16 | The Johns Hopkins University | Nanoparticles for drug delivery to brain |
| CN111658785B (zh) * | 2020-04-21 | 2023-05-12 | 威爱医疗科技(中山)有限公司 | 一种基因载体及其制备方法和应用 |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5034506A (en) | 1985-03-15 | 1991-07-23 | Anti-Gene Development Group | Uncharged morpholino-based polymers having achiral intersubunit linkages |
| US5714331A (en) | 1991-05-24 | 1998-02-03 | Buchardt, Deceased; Ole | Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility |
| US5539082A (en) | 1993-04-26 | 1996-07-23 | Nielsen; Peter E. | Peptide nucleic acids |
| US5527675A (en) | 1993-08-20 | 1996-06-18 | Millipore Corporation | Method for degradation and sequencing of polymers which sequentially eliminate terminal residues |
| DE4331012A1 (de) | 1993-09-13 | 1995-03-16 | Bayer Ag | Nukleinsäuren-bindende Oligomere mit N-Verzweigung für Therapie und Diagnostik |
| US5786571A (en) | 1997-05-09 | 1998-07-28 | Lexmark International, Inc. | Wrapped temperature sensing assembly |
| US6509323B1 (en) | 1998-07-01 | 2003-01-21 | California Institute Of Technology | Linear cyclodextrin copolymers |
| US7022315B2 (en) | 2000-04-26 | 2006-04-04 | Oregon Health & Science University | Administration of a thiol-based chemoprotectant compound |
| WO2002003848A2 (en) | 2000-07-10 | 2002-01-17 | Naito Albert T | Method for opening the blood-brain barrier |
| CA2429814C (en) | 2000-12-01 | 2014-02-18 | Thomas Tuschl | Rna interference mediating small rna molecules |
| US8969314B2 (en) | 2003-07-31 | 2015-03-03 | Regulus Therapeutics, Inc. | Methods for use in modulating miR-122a |
| US7683036B2 (en) | 2003-07-31 | 2010-03-23 | Regulus Therapeutics Inc. | Oligomeric compounds and compositions for use in modulation of small non-coding RNAs |
| US20050142581A1 (en) | 2003-09-04 | 2005-06-30 | Griffey Richard H. | Microrna as ligands and target molecules |
| WO2006093526A2 (en) | 2004-07-21 | 2006-09-08 | Alnylam Pharmaceuticals, Inc. | Oligonucleotides comprising a modified or non-natural nucleobase |
| US20080213891A1 (en) | 2004-07-21 | 2008-09-04 | Alnylam Pharmaceuticals, Inc. | RNAi Agents Comprising Universal Nucleobases |
| AU2005330637B2 (en) | 2004-08-04 | 2012-09-20 | Alnylam Pharmaceuticals, Inc. | Oligonucleotides comprising a ligand tethered to a modified or non-natural nucleobase |
| US20060223777A1 (en) | 2005-03-29 | 2006-10-05 | Dharmacon, Inc. | Highly functional short hairpin RNA |
| AU2006279906B2 (en) | 2005-08-10 | 2012-05-10 | Alnylam Pharmaceuticals, Inc. | Chemically modified oligonucleotides for use in modulating micro RNA and uses thereof |
| US20070213292A1 (en) | 2005-08-10 | 2007-09-13 | The Rockefeller University | Chemically modified oligonucleotides for use in modulating micro RNA and uses thereof |
| EP1931780B1 (en) | 2005-08-29 | 2016-01-06 | Regulus Therapeutics Inc. | Antisense compounds having enhanced anti-microrna activity |
| US8658608B2 (en) | 2005-11-23 | 2014-02-25 | Yale University | Modified triple-helix forming oligonucleotides for targeted mutagenesis |
| AU2007211082B2 (en) | 2006-01-27 | 2012-09-27 | Isis Pharmaceuticals, Inc. | Oligomeric compounds and compositions for the use in modulation of microRNAs |
| EP2007888A2 (en) | 2006-04-03 | 2008-12-31 | Santaris Pharma A/S | Pharmaceutical composition comprising anti-mirna antisense oligonucleotides |
| JP2008053276A (ja) | 2006-08-22 | 2008-03-06 | Nec Electronics Corp | 半導体装置の製造方法 |
| EP2090665A2 (en) | 2006-10-20 | 2009-08-19 | Exiqon A/S | Novel human microRNAs associated with cancer |
| WO2008074328A2 (en) | 2006-12-21 | 2008-06-26 | Exiqon A/S | Microrna target site blocking oligos and uses thereof |
| US20110262406A1 (en) | 2010-04-21 | 2011-10-27 | Yale University | Compositions and methods for targeted inactivation of hiv cell surface receptors |
| US10307372B2 (en) | 2010-09-10 | 2019-06-04 | The Johns Hopkins University | Rapid diffusion of large polymeric nanoparticles in the mammalian brain |
| US20120310140A1 (en) * | 2010-12-01 | 2012-12-06 | Spinal Modulation, Inc. | Directed delivery of agents to neural anatomy |
| WO2012109363A2 (en) * | 2011-02-08 | 2012-08-16 | The Johns Hopkins University | Mucus penetrating gene carriers |
| JP6188728B2 (ja) * | 2012-02-07 | 2017-08-30 | グローバル・バイオ・セラピューティクス・インコーポレイテッドＧｌｏｂａｌ Ｂｉｏ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． | 核酸送達の区画化方法ならびにその組成物および使用 |
-
2015
- 2015-05-12 JP JP2016567385A patent/JP6763780B2/ja active Active
- 2015-05-12 WO PCT/US2015/030381 patent/WO2015175539A1/en not_active Ceased
- 2015-05-12 AU AU2015259362A patent/AU2015259362B2/en active Active
- 2015-05-12 EP EP15724474.0A patent/EP3142704A1/en not_active Withdrawn
- 2015-05-12 CA CA2948844A patent/CA2948844C/en active Active
- 2015-05-12 US US15/310,535 patent/US9937270B2/en active Active
-
2018
- 2018-03-07 US US15/914,796 patent/US10695442B2/en active Active
-
2019
- 2019-12-19 US US16/721,539 patent/US20200129641A1/en not_active Abandoned
-
2020
- 2020-07-06 JP JP2020116339A patent/JP2020172534A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Petkar et al. | Nanostructured materials in drug and gene delivery: a review of the state of the art | |
| da Silva et al. | New perspectives in nanotherapeutics for chronic respiratory diseases | |
| AU2016200683B2 (en) | Nanoparticles with enhanced mucosal penetration or decreased inflammation | |
| Shah et al. | Intranasal delivery: An attractive route for the administration of nucleic acid based therapeutics for CNS disorders | |
| Ghalamfarsa et al. | Application of nanomedicine for crossing the blood–brain barrier: Theranostic opportunities in multiple sclerosis | |
| TWI644674B (zh) | 治療性聚合奈米粒子及其製造及使用方法 | |
| JP2017515839A5 (https=) | ||
| Zhao et al. | Intranasal immunization with O-2′-Hydroxypropyl trimethyl ammonium chloride chitosan nanoparticles loaded with Newcastle disease virus DNA vaccine enhances mucosal immune response in chickens | |
| Chandra et al. | Combining unique properties of dendrimers and magnetic nanoparticles towards cancer theranostics | |
| JP2018533579A5 (https=) | ||
| JP2016522833A (ja) | 医薬組成物、その製造および使用 | |
| CN110139826A (zh) | 具有负的表面电荷的微粒和纳米颗粒 | |
| Xin et al. | Evaluation of rMETase-loaded stealth PLGA/liposomes modified with anti-CAGE scFV for treatment of gastric carcinoma | |
| US20150079007A1 (en) | Tunable multimodal nanoparticles and methods of use thereof | |
| WO2016128591A1 (es) | Procedimiento de obtención de una composición farmacéutica de nanopartículas poliméricas para el tratamiento del dolor neuropático producido por compresión nerviosa periférica | |
| CA2968473A1 (en) | Pharmaceutical composition, preparation and uses thereof | |
| Ravinayagam et al. | Nanomaterials and their negative effects on human health | |
| Edward Werner et al. | Chemoradiotherapy of human tumors: novel approaches from nanomedicine | |
| ES2872552T3 (es) | Nanopartículas poliméricas y métodos de preparación y de uso de las mismas | |
| JP2018534244A5 (https=) | ||
| CN112566627A (zh) | 用于递送病毒的高分子纳米粒子组合物及其制造方法 | |
| Rathi et al. | Treatment of tuberculosis in nano era: recent avenues | |
| CN118697901A (zh) | 一种吸入式IL-10 mRNA纳米制剂及其制备方法和应用 | |
| JP6661700B2 (ja) | タキサンを含有するナノ粒子およびその使用 | |
| US12589133B2 (en) | Methods of downregulating CCL20 genes for treatment of traumatic brain injuries |