JP2017515839A5 - - Google Patents

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Publication number
JP2017515839A5
JP2017515839A5 JP2016567385A JP2016567385A JP2017515839A5 JP 2017515839 A5 JP2017515839 A5 JP 2017515839A5 JP 2016567385 A JP2016567385 A JP 2016567385A JP 2016567385 A JP2016567385 A JP 2016567385A JP 2017515839 A5 JP2017515839 A5 JP 2017515839A5
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JP
Japan
Prior art keywords
formulation
brain
nanoparticle
polymer
hydrophilic polymer
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JP2016567385A
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English (en)
Japanese (ja)
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JP6763780B2 (ja
JP2017515839A (ja
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Priority claimed from PCT/US2015/030381 external-priority patent/WO2015175539A1/en
Publication of JP2017515839A publication Critical patent/JP2017515839A/ja
Publication of JP2017515839A5 publication Critical patent/JP2017515839A5/ja
Application granted granted Critical
Publication of JP6763780B2 publication Critical patent/JP6763780B2/ja
Active legal-status Critical Current
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JP2016567385A 2014-05-12 2015-05-12 合成脳浸透遺伝子ベクターの操作 Active JP6763780B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201461991898P 2014-05-12 2014-05-12
US201461991920P 2014-05-12 2014-05-12
US61/991,920 2014-05-12
US61/991,898 2014-05-12
US201462001994P 2014-05-22 2014-05-22
US62/001,994 2014-05-22
PCT/US2015/030381 WO2015175539A1 (en) 2014-05-12 2015-05-12 Engineering synthetic brain penetrating gene vectors

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2020116339A Division JP2020172534A (ja) 2014-05-12 2020-07-06 合成脳浸透遺伝子ベクターの操作

Publications (3)

Publication Number Publication Date
JP2017515839A JP2017515839A (ja) 2017-06-15
JP2017515839A5 true JP2017515839A5 (enExample) 2018-04-26
JP6763780B2 JP6763780B2 (ja) 2020-09-30

Family

ID=53264811

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2016567385A Active JP6763780B2 (ja) 2014-05-12 2015-05-12 合成脳浸透遺伝子ベクターの操作
JP2020116339A Pending JP2020172534A (ja) 2014-05-12 2020-07-06 合成脳浸透遺伝子ベクターの操作

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2020116339A Pending JP2020172534A (ja) 2014-05-12 2020-07-06 合成脳浸透遺伝子ベクターの操作

Country Status (6)

Country Link
US (3) US9937270B2 (enExample)
EP (1) EP3142704A1 (enExample)
JP (2) JP6763780B2 (enExample)
AU (1) AU2015259362B2 (enExample)
CA (1) CA2948844C (enExample)
WO (1) WO2015175539A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011106702A2 (en) 2010-02-25 2011-09-01 The Johns Hopkins University Sustained delivery of therapeutic agents to an eye compartment
WO2017044759A1 (en) * 2015-09-11 2017-03-16 The Johns Hopkins University Compositions and methods to improve nanoparticle distribution within the brain interstitium
WO2020210805A1 (en) * 2019-04-11 2020-10-15 The Johns Hopkins University Nanoparticles for drug delivery to brain
CN111658785B (zh) * 2020-04-21 2023-05-12 威爱医疗科技(中山)有限公司 一种基因载体及其制备方法和应用

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5034506A (en) 1985-03-15 1991-07-23 Anti-Gene Development Group Uncharged morpholino-based polymers having achiral intersubunit linkages
US5714331A (en) 1991-05-24 1998-02-03 Buchardt, Deceased; Ole Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility
US5539082A (en) 1993-04-26 1996-07-23 Nielsen; Peter E. Peptide nucleic acids
US5527675A (en) 1993-08-20 1996-06-18 Millipore Corporation Method for degradation and sequencing of polymers which sequentially eliminate terminal residues
DE4331012A1 (de) 1993-09-13 1995-03-16 Bayer Ag Nukleinsäuren-bindende Oligomere mit N-Verzweigung für Therapie und Diagnostik
US5786571A (en) 1997-05-09 1998-07-28 Lexmark International, Inc. Wrapped temperature sensing assembly
US6509323B1 (en) 1998-07-01 2003-01-21 California Institute Of Technology Linear cyclodextrin copolymers
CA2406081C (en) 2000-04-26 2009-12-22 Oregon Health Sciences University Administration of a thiol-based chemoprotectant compound
AU2001271345A1 (en) 2000-07-10 2002-01-21 Albert T. Naito Method for opening the blood-brain barrier
RU2322500C2 (ru) 2000-12-01 2008-04-20 Макс-Планк-Гезелльшафт Цур Фердерунг Дер Виссеншафтен Е.Ф. Малые молекулы рнк, опосредующие интерференцию рнк
EP1648914A4 (en) 2003-07-31 2009-12-16 Regulus Therapeutics Inc OLIGOMERIC COMPOUNDS AND COMPOSITIONS USEFUL FOR MODULATING SMALL NON-CODING RNA
US8969314B2 (en) 2003-07-31 2015-03-03 Regulus Therapeutics, Inc. Methods for use in modulating miR-122a
US20050142581A1 (en) 2003-09-04 2005-06-30 Griffey Richard H. Microrna as ligands and target molecules
US20080213891A1 (en) 2004-07-21 2008-09-04 Alnylam Pharmaceuticals, Inc. RNAi Agents Comprising Universal Nucleobases
US7579451B2 (en) 2004-07-21 2009-08-25 Alnylam Pharmaceuticals, Inc. Oligonucleotides comprising a modified or non-natural nucleobase
WO2006112872A2 (en) 2004-08-04 2006-10-26 Alnylam Pharmaceuticals, Inc. Oligonucleotides comprising a ligand tethered to a modified or non-natural nucleobase
US20060223777A1 (en) 2005-03-29 2006-10-05 Dharmacon, Inc. Highly functional short hairpin RNA
US20070213292A1 (en) 2005-08-10 2007-09-13 The Rockefeller University Chemically modified oligonucleotides for use in modulating micro RNA and uses thereof
AU2006279906B2 (en) 2005-08-10 2012-05-10 Alnylam Pharmaceuticals, Inc. Chemically modified oligonucleotides for use in modulating micro RNA and uses thereof
WO2007027894A2 (en) 2005-08-29 2007-03-08 Isis Pharmaceuticals, Inc. Antisense compounds having enhanced anti-microrna activity
US8658608B2 (en) 2005-11-23 2014-02-25 Yale University Modified triple-helix forming oligonucleotides for targeted mutagenesis
EP2388327A1 (en) 2006-01-27 2011-11-23 Isis Pharmaceuticals, Inc. Oligomeric compounds and compositions for the use in modulation of micrornas
KR101407707B1 (ko) 2006-04-03 2014-06-19 산타리스 팔마 에이/에스 Anti-mirna 안티센스 올리고뉴클레오타이드를 함유하는 약학적 조성물
JP2008053276A (ja) 2006-08-22 2008-03-06 Nec Electronics Corp 半導体装置の製造方法
EP2090665A2 (en) 2006-10-20 2009-08-19 Exiqon A/S Novel human microRNAs associated with cancer
US20090137504A1 (en) 2006-12-21 2009-05-28 Soren Morgenthaler Echwald Microrna target site blocking oligos and uses thereof
US20110262406A1 (en) 2010-04-21 2011-10-27 Yale University Compositions and methods for targeted inactivation of hiv cell surface receptors
WO2012039979A2 (en) 2010-09-10 2012-03-29 The Johns Hopkins University Rapid diffusion of large polymeric nanoparticles in the mammalian brain
CA2819635A1 (en) * 2010-12-01 2012-06-07 Spinal Modulation, Inc. Directed delivery of agents to neural anatomy
WO2012109363A2 (en) * 2011-02-08 2012-08-16 The Johns Hopkins University Mucus penetrating gene carriers
CN107982548A (zh) * 2012-02-07 2018-05-04 全球生物疗法有限公司 核酸输送的区室化方法及其组合物和应用

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