JP2017515839A5 - - Google Patents
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- Publication number
- JP2017515839A5 JP2017515839A5 JP2016567385A JP2016567385A JP2017515839A5 JP 2017515839 A5 JP2017515839 A5 JP 2017515839A5 JP 2016567385 A JP2016567385 A JP 2016567385A JP 2016567385 A JP2016567385 A JP 2016567385A JP 2017515839 A5 JP2017515839 A5 JP 2017515839A5
- Authority
- JP
- Japan
- Prior art keywords
- formulation
- brain
- nanoparticle
- polymer
- hydrophilic polymer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461991920P | 2014-05-12 | 2014-05-12 | |
| US201461991898P | 2014-05-12 | 2014-05-12 | |
| US61/991,898 | 2014-05-12 | ||
| US61/991,920 | 2014-05-12 | ||
| US201462001994P | 2014-05-22 | 2014-05-22 | |
| US62/001,994 | 2014-05-22 | ||
| PCT/US2015/030381 WO2015175539A1 (en) | 2014-05-12 | 2015-05-12 | Engineering synthetic brain penetrating gene vectors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020116339A Division JP2020172534A (ja) | 2014-05-12 | 2020-07-06 | 合成脳浸透遺伝子ベクターの操作 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017515839A JP2017515839A (ja) | 2017-06-15 |
| JP2017515839A5 true JP2017515839A5 (cg-RX-API-DMAC10.html) | 2018-04-26 |
| JP6763780B2 JP6763780B2 (ja) | 2020-09-30 |
Family
ID=53264811
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016567385A Active JP6763780B2 (ja) | 2014-05-12 | 2015-05-12 | 合成脳浸透遺伝子ベクターの操作 |
| JP2020116339A Pending JP2020172534A (ja) | 2014-05-12 | 2020-07-06 | 合成脳浸透遺伝子ベクターの操作 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020116339A Pending JP2020172534A (ja) | 2014-05-12 | 2020-07-06 | 合成脳浸透遺伝子ベクターの操作 |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US9937270B2 (cg-RX-API-DMAC10.html) |
| EP (1) | EP3142704A1 (cg-RX-API-DMAC10.html) |
| JP (2) | JP6763780B2 (cg-RX-API-DMAC10.html) |
| AU (1) | AU2015259362B2 (cg-RX-API-DMAC10.html) |
| CA (1) | CA2948844C (cg-RX-API-DMAC10.html) |
| WO (1) | WO2015175539A1 (cg-RX-API-DMAC10.html) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8889193B2 (en) | 2010-02-25 | 2014-11-18 | The Johns Hopkins University | Sustained delivery of therapeutic agents to an eye compartment |
| WO2017044759A1 (en) * | 2015-09-11 | 2017-03-16 | The Johns Hopkins University | Compositions and methods to improve nanoparticle distribution within the brain interstitium |
| WO2020210805A1 (en) * | 2019-04-11 | 2020-10-15 | The Johns Hopkins University | Nanoparticles for drug delivery to brain |
| CN111658785B (zh) * | 2020-04-21 | 2023-05-12 | 威爱医疗科技(中山)有限公司 | 一种基因载体及其制备方法和应用 |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5034506A (en) | 1985-03-15 | 1991-07-23 | Anti-Gene Development Group | Uncharged morpholino-based polymers having achiral intersubunit linkages |
| US5539082A (en) | 1993-04-26 | 1996-07-23 | Nielsen; Peter E. | Peptide nucleic acids |
| US5714331A (en) | 1991-05-24 | 1998-02-03 | Buchardt, Deceased; Ole | Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility |
| US5527675A (en) | 1993-08-20 | 1996-06-18 | Millipore Corporation | Method for degradation and sequencing of polymers which sequentially eliminate terminal residues |
| DE4331012A1 (de) | 1993-09-13 | 1995-03-16 | Bayer Ag | Nukleinsäuren-bindende Oligomere mit N-Verzweigung für Therapie und Diagnostik |
| US5786571A (en) | 1997-05-09 | 1998-07-28 | Lexmark International, Inc. | Wrapped temperature sensing assembly |
| US6509323B1 (en) | 1998-07-01 | 2003-01-21 | California Institute Of Technology | Linear cyclodextrin copolymers |
| KR20030014208A (ko) | 2000-04-26 | 2003-02-15 | 오레곤 헬스 사이언시즈 유니버시티 | 티올계 화학보호제 화합물의 투여 |
| WO2002003848A2 (en) | 2000-07-10 | 2002-01-17 | Naito Albert T | Method for opening the blood-brain barrier |
| CN100523215C (zh) | 2000-12-01 | 2009-08-05 | 马普科技促进协会 | 介导rna干涉的小rna分子 |
| WO2005013901A2 (en) | 2003-07-31 | 2005-02-17 | Isis Pharmaceuticals, Inc. | Oligomeric compounds and compositions for use in modulation of small non-coding rnas |
| US20050142581A1 (en) | 2003-09-04 | 2005-06-30 | Griffey Richard H. | Microrna as ligands and target molecules |
| AU2005328382C1 (en) | 2004-07-21 | 2013-01-24 | Alnylam Pharmaceuticals, Inc. | Oligonucleotides comprising a modified or non-natural nucleobase |
| US20080213891A1 (en) | 2004-07-21 | 2008-09-04 | Alnylam Pharmaceuticals, Inc. | RNAi Agents Comprising Universal Nucleobases |
| EP1913011B1 (en) | 2004-08-04 | 2016-11-02 | Alnylam Pharmaceuticals Inc. | Oligonucleotides comprising a ligand tethered to a modified or non-natural nucleobase |
| US20060223777A1 (en) | 2005-03-29 | 2006-10-05 | Dharmacon, Inc. | Highly functional short hairpin RNA |
| US20070213292A1 (en) | 2005-08-10 | 2007-09-13 | The Rockefeller University | Chemically modified oligonucleotides for use in modulating micro RNA and uses thereof |
| AU2006279906B2 (en) | 2005-08-10 | 2012-05-10 | Alnylam Pharmaceuticals, Inc. | Chemically modified oligonucleotides for use in modulating micro RNA and uses thereof |
| WO2007027894A2 (en) | 2005-08-29 | 2007-03-08 | Isis Pharmaceuticals, Inc. | Antisense compounds having enhanced anti-microrna activity |
| ATE494372T1 (de) | 2005-08-29 | 2011-01-15 | Regulus Therapeutics Inc | Verfahren für mir-122a-modulation |
| US8658608B2 (en) | 2005-11-23 | 2014-02-25 | Yale University | Modified triple-helix forming oligonucleotides for targeted mutagenesis |
| EP2388328A1 (en) | 2006-01-27 | 2011-11-23 | Isis Pharmaceuticals, Inc. | Oligomeric compounds and compositions for the use in modulation of micrornas |
| CA3042781C (en) | 2006-04-03 | 2021-10-19 | Roche Innovation Center Copenhagen A/S | Pharmaceutical composition comprising anti-mirna antisense oligonucleotides |
| JP2008053276A (ja) | 2006-08-22 | 2008-03-06 | Nec Electronics Corp | 半導体装置の製造方法 |
| EP2090665A2 (en) | 2006-10-20 | 2009-08-19 | Exiqon A/S | Novel human microRNAs associated with cancer |
| US20090137504A1 (en) | 2006-12-21 | 2009-05-28 | Soren Morgenthaler Echwald | Microrna target site blocking oligos and uses thereof |
| US20110262406A1 (en) | 2010-04-21 | 2011-10-27 | Yale University | Compositions and methods for targeted inactivation of hiv cell surface receptors |
| WO2012039979A2 (en) | 2010-09-10 | 2012-03-29 | The Johns Hopkins University | Rapid diffusion of large polymeric nanoparticles in the mammalian brain |
| US20120310140A1 (en) * | 2010-12-01 | 2012-12-06 | Spinal Modulation, Inc. | Directed delivery of agents to neural anatomy |
| WO2012109363A2 (en) * | 2011-02-08 | 2012-08-16 | The Johns Hopkins University | Mucus penetrating gene carriers |
| SG10201604810UA (en) * | 2012-02-07 | 2016-08-30 | Global Bio Therapeutics Inc | Compartmentalized method of nucleic acid delivery and compositions and uses thereof |
-
2015
- 2015-05-12 JP JP2016567385A patent/JP6763780B2/ja active Active
- 2015-05-12 US US15/310,535 patent/US9937270B2/en active Active
- 2015-05-12 AU AU2015259362A patent/AU2015259362B2/en active Active
- 2015-05-12 CA CA2948844A patent/CA2948844C/en active Active
- 2015-05-12 EP EP15724474.0A patent/EP3142704A1/en not_active Withdrawn
- 2015-05-12 WO PCT/US2015/030381 patent/WO2015175539A1/en not_active Ceased
-
2018
- 2018-03-07 US US15/914,796 patent/US10695442B2/en active Active
-
2019
- 2019-12-19 US US16/721,539 patent/US20200129641A1/en not_active Abandoned
-
2020
- 2020-07-06 JP JP2020116339A patent/JP2020172534A/ja active Pending
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