JP2017511340A5 - - Google Patents
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- Publication number
- JP2017511340A5 JP2017511340A5 JP2016560750A JP2016560750A JP2017511340A5 JP 2017511340 A5 JP2017511340 A5 JP 2017511340A5 JP 2016560750 A JP2016560750 A JP 2016560750A JP 2016560750 A JP2016560750 A JP 2016560750A JP 2017511340 A5 JP2017511340 A5 JP 2017511340A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- cancer
- halogen
- compound
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 42
- 229910052736 halogen Inorganic materials 0.000 claims 31
- 150000002367 halogens Chemical class 0.000 claims 31
- 238000000034 method Methods 0.000 claims 13
- 206010028980 Neoplasm Diseases 0.000 claims 11
- 201000011510 cancer Diseases 0.000 claims 10
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 6
- 208000031671 Large B-Cell Diffuse Lymphoma Diseases 0.000 claims 5
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 5
- 206010012818 diffuse large B-cell lymphoma Diseases 0.000 claims 5
- 201000005202 lung cancer Diseases 0.000 claims 5
- 208000020816 lung neoplasm Diseases 0.000 claims 5
- 206010006187 Breast cancer Diseases 0.000 claims 4
- 208000026310 Breast neoplasm Diseases 0.000 claims 4
- 206010009944 Colon cancer Diseases 0.000 claims 4
- 206010060862 Prostate cancer Diseases 0.000 claims 4
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 4
- 206010039491 Sarcoma Diseases 0.000 claims 4
- 208000009956 adenocarcinoma Diseases 0.000 claims 4
- 208000029742 colonic neoplasm Diseases 0.000 claims 4
- 208000032839 leukemia Diseases 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 3
- 206010033128 Ovarian cancer Diseases 0.000 claims 3
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 3
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 3
- 206010038389 Renal cancer Diseases 0.000 claims 3
- 208000024313 Testicular Neoplasms Diseases 0.000 claims 3
- 201000010982 kidney cancer Diseases 0.000 claims 3
- 239000012453 solvate Substances 0.000 claims 3
- 201000003120 testicular cancer Diseases 0.000 claims 3
- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 claims 2
- 208000014697 Acute lymphocytic leukaemia Diseases 0.000 claims 2
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 2
- 201000003076 Angiosarcoma Diseases 0.000 claims 2
- 208000003950 B-cell lymphoma Diseases 0.000 claims 2
- 206010004146 Basal cell carcinoma Diseases 0.000 claims 2
- 206010005003 Bladder cancer Diseases 0.000 claims 2
- 206010008342 Cervix carcinoma Diseases 0.000 claims 2
- 208000001258 Hemangiosarcoma Diseases 0.000 claims 2
- 208000017604 Hodgkin disease Diseases 0.000 claims 2
- 208000021519 Hodgkin lymphoma Diseases 0.000 claims 2
- 208000010747 Hodgkins lymphoma Diseases 0.000 claims 2
- 206010025323 Lymphomas Diseases 0.000 claims 2
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 claims 2
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims 2
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 2
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims 2
- 208000006265 Renal cell carcinoma Diseases 0.000 claims 2
- 208000027585 T-cell non-Hodgkin lymphoma Diseases 0.000 claims 2
- 206010057644 Testis cancer Diseases 0.000 claims 2
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 2
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 2
- 208000002495 Uterine Neoplasms Diseases 0.000 claims 2
- 230000021736 acetylation Effects 0.000 claims 2
- 238000006640 acetylation reaction Methods 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 201000010881 cervical cancer Diseases 0.000 claims 2
- 230000003511 endothelial effect Effects 0.000 claims 2
- 201000003444 follicular lymphoma Diseases 0.000 claims 2
- 210000001280 germinal center Anatomy 0.000 claims 2
- 201000007270 liver cancer Diseases 0.000 claims 2
- 208000014018 liver neoplasm Diseases 0.000 claims 2
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 2
- 201000001441 melanoma Diseases 0.000 claims 2
- 201000000050 myeloid neoplasm Diseases 0.000 claims 2
- 201000008968 osteosarcoma Diseases 0.000 claims 2
- 201000002528 pancreatic cancer Diseases 0.000 claims 2
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 208000015347 renal cell adenocarcinoma Diseases 0.000 claims 2
- 201000005112 urinary bladder cancer Diseases 0.000 claims 2
- 206010046766 uterine cancer Diseases 0.000 claims 2
- NAWXUBYGYWOOIX-SFHVURJKSA-N (2s)-2-[[4-[2-(2,4-diaminoquinazolin-6-yl)ethyl]benzoyl]amino]-4-methylidenepentanedioic acid Chemical compound C1=CC2=NC(N)=NC(N)=C2C=C1CCC1=CC=C(C(=O)N[C@@H](CC(=C)C(O)=O)C(O)=O)C=C1 NAWXUBYGYWOOIX-SFHVURJKSA-N 0.000 claims 1
- 206010003571 Astrocytoma Diseases 0.000 claims 1
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims 1
- 208000028564 B-cell non-Hodgkin lymphoma Diseases 0.000 claims 1
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 claims 1
- 208000005440 Basal Cell Neoplasms Diseases 0.000 claims 1
- 206010004593 Bile duct cancer Diseases 0.000 claims 1
- 208000003174 Brain Neoplasms Diseases 0.000 claims 1
- 201000009030 Carcinoma Diseases 0.000 claims 1
- 208000005243 Chondrosarcoma Diseases 0.000 claims 1
- 201000009047 Chordoma Diseases 0.000 claims 1
- 208000006332 Choriocarcinoma Diseases 0.000 claims 1
- 208000010833 Chronic myeloid leukaemia Diseases 0.000 claims 1
- 208000009798 Craniopharyngioma Diseases 0.000 claims 1
- 206010014967 Ependymoma Diseases 0.000 claims 1
- 208000006168 Ewing Sarcoma Diseases 0.000 claims 1
- 201000008808 Fibrosarcoma Diseases 0.000 claims 1
- 206010017993 Gastrointestinal neoplasms Diseases 0.000 claims 1
- 208000032612 Glial tumor Diseases 0.000 claims 1
- 206010018338 Glioma Diseases 0.000 claims 1
- 208000018142 Leiomyosarcoma Diseases 0.000 claims 1
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 claims 1
- 208000000172 Medulloblastoma Diseases 0.000 claims 1
- 206010027406 Mesothelioma Diseases 0.000 claims 1
- 206010027480 Metastatic malignant melanoma Diseases 0.000 claims 1
- 208000034578 Multiple myelomas Diseases 0.000 claims 1
- 101100381525 Mus musculus Bcl6 gene Proteins 0.000 claims 1
- 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 claims 1
- 206010029260 Neuroblastoma Diseases 0.000 claims 1
- 208000007641 Pinealoma Diseases 0.000 claims 1
- 201000000582 Retinoblastoma Diseases 0.000 claims 1
- 201000010208 Seminoma Diseases 0.000 claims 1
- 206010041067 Small cell lung cancer Diseases 0.000 claims 1
- 208000021712 Soft tissue sarcoma Diseases 0.000 claims 1
- 208000000389 T-cell leukemia Diseases 0.000 claims 1
- 208000028530 T-cell lymphoblastic leukemia/lymphoma Diseases 0.000 claims 1
- 206010042971 T-cell lymphoma Diseases 0.000 claims 1
- 208000014070 Vestibular schwannoma Diseases 0.000 claims 1
- 208000016025 Waldenstroem macroglobulinemia Diseases 0.000 claims 1
- 208000033559 Waldenström macroglobulinemia Diseases 0.000 claims 1
- 208000008383 Wilms tumor Diseases 0.000 claims 1
- 208000004064 acoustic neuroma Diseases 0.000 claims 1
- 210000003719 b-lymphocyte Anatomy 0.000 claims 1
- 208000026900 bile duct neoplasm Diseases 0.000 claims 1
- 201000000053 blastoma Diseases 0.000 claims 1
- 208000003362 bronchogenic carcinoma Diseases 0.000 claims 1
- 201000007455 central nervous system cancer Diseases 0.000 claims 1
- 208000006990 cholangiocarcinoma Diseases 0.000 claims 1
- 208000032852 chronic lymphocytic leukemia Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 201000008184 embryoma Diseases 0.000 claims 1
- 210000000981 epithelium Anatomy 0.000 claims 1
- 206010016629 fibroma Diseases 0.000 claims 1
- 201000002222 hemangioblastoma Diseases 0.000 claims 1
- 208000019691 hematopoietic and lymphoid cell neoplasm Diseases 0.000 claims 1
- 206010073071 hepatocellular carcinoma Diseases 0.000 claims 1
- 231100000844 hepatocellular carcinoma Toxicity 0.000 claims 1
- 206010024627 liposarcoma Diseases 0.000 claims 1
- 208000012804 lymphangiosarcoma Diseases 0.000 claims 1
- 230000001926 lymphatic effect Effects 0.000 claims 1
- 206010027191 meningioma Diseases 0.000 claims 1
- 208000021039 metastatic melanoma Diseases 0.000 claims 1
- 208000001611 myxosarcoma Diseases 0.000 claims 1
- 208000025189 neoplasm of testis Diseases 0.000 claims 1
- 201000008026 nephroblastoma Diseases 0.000 claims 1
- 210000004498 neuroglial cell Anatomy 0.000 claims 1
- 208000004019 papillary adenocarcinoma Diseases 0.000 claims 1
- 208000024724 pineal body neoplasm Diseases 0.000 claims 1
- 201000009410 rhabdomyosarcoma Diseases 0.000 claims 1
- 208000018964 sebaceous gland cancer Diseases 0.000 claims 1
- 208000000587 small cell lung carcinoma Diseases 0.000 claims 1
- 206010041823 squamous cell carcinoma Diseases 0.000 claims 1
- 208000017572 squamous cell neoplasm Diseases 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 201000008759 sweat gland cancer Diseases 0.000 claims 1
- 201000008753 synovium neoplasm Diseases 0.000 claims 1
- 208000008732 thymoma Diseases 0.000 claims 1
- 208000013077 thyroid gland carcinoma Diseases 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461972571P | 2014-03-31 | 2014-03-31 | |
| US61/972,571 | 2014-03-31 | ||
| US201462023715P | 2014-07-11 | 2014-07-11 | |
| US62/023,715 | 2014-07-11 | ||
| PCT/US2015/023258 WO2015153410A1 (en) | 2014-03-31 | 2015-03-30 | Histone acetyltransferase activators and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017511340A JP2017511340A (ja) | 2017-04-20 |
| JP2017511340A5 true JP2017511340A5 (https=) | 2018-05-17 |
Family
ID=54241152
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016560750A Pending JP2017511340A (ja) | 2014-03-31 | 2015-03-30 | ヒストンアセチルトランスフェラーゼ活性剤及びその使用 |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US20170182054A1 (https=) |
| EP (2) | EP3126332A4 (https=) |
| JP (1) | JP2017511340A (https=) |
| CN (1) | CN106604913A (https=) |
| AU (2) | AU2015241177B2 (https=) |
| BR (1) | BR112016022879A2 (https=) |
| CA (1) | CA2944613A1 (https=) |
| IL (1) | IL248144A0 (https=) |
| WO (1) | WO2015153410A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL292457A (en) | 2016-07-20 | 2022-06-01 | Univ Columbia | Histone acetyl transferase activators, their preparations and their uses |
| JP7134173B2 (ja) * | 2017-06-21 | 2022-09-09 | 第一三共株式会社 | Ｅｐ３００／ｃｒｅｂｂｐ阻害剤 |
| WO2020163746A1 (en) * | 2019-02-08 | 2020-08-13 | The Trustees Of Columbia University In The City Of New York | Histone acetyltransferase (hat) regulators and uses thereof |
| CN113613646A (zh) * | 2019-02-08 | 2021-11-05 | 纽约市哥伦比亚大学理事会 | 组蛋白乙酰基转移酶调节剂及其组合物和用途 |
| US20220257601A1 (en) * | 2019-06-27 | 2022-08-18 | Board Of Regents, The University Of Texas System | Inhibitors of prc1 for treatment of cancer |
| BR112022010127A2 (pt) * | 2019-11-25 | 2022-09-06 | Gain Therapeutics Sa | Compostos de arila e heteroarila e usos terapêuticos dos mesmos em condições associadas à alteração da atividade de galatocerebrosidase |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3449420A (en) * | 1966-01-15 | 1969-06-10 | Hoechst Ag | Gamma-resorcylic acid anilides and process for preparing them |
| HUP0102782A3 (en) * | 1998-06-19 | 2002-12-28 | Smithkline Beecham Corp | Salycilanilide as inhibitors of transcription factor nf-kb |
| US7332629B2 (en) | 2002-12-12 | 2008-02-19 | Jawaharlal Nehru Centre For Advanced Scientific Research | Modulators (inhibitors/activators) of histone acetyltransferases |
| EP1590318A2 (en) * | 2002-12-12 | 2005-11-02 | Jawaharlal Nehru Centre For Advanced Scientific Research | Modulators (inhibitors/activators) of histone acetyltransferases |
| ATE467616T1 (de) * | 2003-04-11 | 2010-05-15 | High Point Pharmaceuticals Llc | Verbindungen mit aktivität an der 11beta- hydroxasteroiddehydrogenase |
| US7868008B2 (en) * | 2005-08-12 | 2011-01-11 | Astrazeneca Ab | Substituted isoindolones and their use as metabotropic glutamate receptor potentiators |
| US20100144885A1 (en) | 2006-09-29 | 2010-06-10 | The Board Of Trustees Of The University Of Illinois | Histone acetyl transferase activators and histone deacetylase inhibitors in the treatment of alcoholism |
| CA2574531C (en) | 2007-01-19 | 2016-10-25 | The University Of British Columbia | Hat acetylation promoters and uses of compositions thereof in promoting immunogenicity |
| JP5142858B2 (ja) | 2008-07-03 | 2013-02-13 | キヤノン株式会社 | 画像処理装置および画像処理方法 |
| MX2012003778A (es) * | 2009-09-29 | 2012-06-01 | Glaxo Group Ltd | Compuestos novedosos. |
| WO2011072243A1 (en) | 2009-12-10 | 2011-06-16 | The Trustees Of Columbia University In The City Of New York | Histone acetyltransferase activators and uses thereof |
| US10640457B2 (en) | 2009-12-10 | 2020-05-05 | The Trustees Of Columbia University In The City Of New York | Histone acetyltransferase activators and uses thereof |
| JPWO2012081570A1 (ja) * | 2010-12-14 | 2014-05-22 | あすか製薬株式会社 | ラクタム化合物又はその塩及びｐｐａｒ活性化剤 |
| WO2012088420A1 (en) * | 2010-12-22 | 2012-06-28 | The Trustees Of Columbia University In The City Of New York | Histone acetyltransferase modulators and usese thereof |
| CN107095864A (zh) | 2011-06-10 | 2017-08-29 | 纽约市哥伦比亚大学理事会 | 组蛋白乙酰转移酶激活剂的用途 |
| KR101434461B1 (ko) * | 2011-10-21 | 2014-09-01 | 한국생명공학연구원 | 2-하이드록시아릴아마이드 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 암 예방 또는 치료용 약학적 조성물 |
| WO2013058613A2 (ko) * | 2011-10-21 | 2013-04-25 | 한국생명공학연구원 | 2-하이드록시아릴아마이드 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 암 예방 또는 치료용 약학적 조성물 |
| CN105658792B (zh) | 2012-02-28 | 2020-11-10 | 西格马-奥尔德里奇有限责任公司 | 靶向组蛋白乙酰化 |
| IL292457A (en) * | 2016-07-20 | 2022-06-01 | Univ Columbia | Histone acetyl transferase activators, their preparations and their uses |
-
2015
- 2015-03-30 WO PCT/US2015/023258 patent/WO2015153410A1/en not_active Ceased
- 2015-03-30 CA CA2944613A patent/CA2944613A1/en not_active Abandoned
- 2015-03-30 AU AU2015241177A patent/AU2015241177B2/en not_active Ceased
- 2015-03-30 JP JP2016560750A patent/JP2017511340A/ja active Pending
- 2015-03-30 CN CN201580027967.1A patent/CN106604913A/zh active Pending
- 2015-03-30 BR BR112016022879A patent/BR112016022879A2/pt not_active Application Discontinuation
- 2015-03-30 US US15/300,497 patent/US20170182054A1/en not_active Abandoned
- 2015-03-30 EP EP15774440.0A patent/EP3126332A4/en not_active Withdrawn
- 2015-03-30 EP EP18158529.0A patent/EP3398937A1/en not_active Withdrawn
-
2016
- 2016-09-29 IL IL248144A patent/IL248144A0/en unknown
-
2018
- 2018-01-11 US US15/868,458 patent/US20180360842A1/en not_active Abandoned
-
2019
- 2019-12-02 US US16/700,693 patent/US11191768B2/en not_active Expired - Fee Related
- 2019-12-12 AU AU2019280031A patent/AU2019280031A1/en not_active Abandoned
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