JP2017510262A5 - - Google Patents
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- Publication number
- JP2017510262A5 JP2017510262A5 JP2016555659A JP2016555659A JP2017510262A5 JP 2017510262 A5 JP2017510262 A5 JP 2017510262A5 JP 2016555659 A JP2016555659 A JP 2016555659A JP 2016555659 A JP2016555659 A JP 2016555659A JP 2017510262 A5 JP2017510262 A5 JP 2017510262A5
- Authority
- JP
- Japan
- Prior art keywords
- hsv
- recombinant
- glycoprotein
- herpes simplex
- simplex virus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 241000701074 Human alphaherpesvirus 2 Species 0.000 claims 43
- 108010090054 Membrane Glycoproteins Proteins 0.000 claims 12
- 102000012750 Membrane Glycoproteins Human genes 0.000 claims 12
- 239000000232 Lipid Bilayer Substances 0.000 claims 7
- 210000004027 cell Anatomy 0.000 claims 7
- 108090000623 proteins and genes Proteins 0.000 claims 7
- 102000003886 Glycoproteins Human genes 0.000 claims 6
- 108090000288 Glycoproteins Proteins 0.000 claims 6
- 229960005486 vaccine Drugs 0.000 claims 5
- 241000700588 Human alphaherpesvirus 1 Species 0.000 claims 4
- 229920002978 Vinylon Polymers 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 210000000170 cell membrane Anatomy 0.000 claims 3
- 208000015181 infectious disease Diseases 0.000 claims 3
- 244000045947 parasite Species 0.000 claims 3
- 210000002845 virion Anatomy 0.000 claims 3
- 230000010056 antibody-dependent cellular cytotoxicity Effects 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 230000001939 inductive effect Effects 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 102100022717 Atypical chemokine receptor 1 Human genes 0.000 claims 1
- 241000894006 Bacteria Species 0.000 claims 1
- 208000037952 HSV-1 infection Diseases 0.000 claims 1
- 101000678879 Homo sapiens Atypical chemokine receptor 1 Proteins 0.000 claims 1
- 241000700584 Simplexvirus Species 0.000 claims 1
- 108700019146 Transgenes Proteins 0.000 claims 1
- 208000025865 Ulcer Diseases 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 230000000890 antigenic effect Effects 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 210000004392 genitalia Anatomy 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 150000002632 lipids Chemical class 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 230000010076 replication Effects 0.000 claims 1
- 231100000397 ulcer Toxicity 0.000 claims 1
- 238000002255 vaccination Methods 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461946965P | 2014-03-03 | 2014-03-03 | |
| US61/946,965 | 2014-03-03 | ||
| US201462080663P | 2014-11-17 | 2014-11-17 | |
| US62/080,663 | 2014-11-17 | ||
| PCT/US2015/018272 WO2015134368A2 (en) | 2014-03-03 | 2015-03-02 | Recombinant herpes simplex virus 2 (hsv-2) vaccine vectors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020009043A Division JP6844045B2 (ja) | 2014-03-03 | 2020-01-23 | 組換え単純ヘルペスウィルス２（ｈｓｖ−２）ワクチンベクター |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017510262A JP2017510262A (ja) | 2017-04-13 |
| JP2017510262A5 true JP2017510262A5 (OSRAM) | 2018-04-12 |
| JP6652497B2 JP6652497B2 (ja) | 2020-02-26 |
Family
ID=54055977
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016555659A Active JP6652497B2 (ja) | 2014-03-03 | 2015-03-02 | 組換え単純ヘルペスウィルス２（ｈｓｖ−２）ワクチンベクター |
| JP2020009043A Active JP6844045B2 (ja) | 2014-03-03 | 2020-01-23 | 組換え単純ヘルペスウィルス２（ｈｓｖ−２）ワクチンベクター |
| JP2021026943A Active JP7050193B2 (ja) | 2014-03-03 | 2021-02-24 | 組換え単純ヘルペスウィルス２（ｈｓｖ－２）ワクチンベクター |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020009043A Active JP6844045B2 (ja) | 2014-03-03 | 2020-01-23 | 組換え単純ヘルペスウィルス２（ｈｓｖ−２）ワクチンベクター |
| JP2021026943A Active JP7050193B2 (ja) | 2014-03-03 | 2021-02-24 | 組換え単純ヘルペスウィルス２（ｈｓｖ－２）ワクチンベクター |
Country Status (7)
| Country | Link |
|---|---|
| US (5) | US9999665B2 (OSRAM) |
| EP (2) | EP3943106A1 (OSRAM) |
| JP (3) | JP6652497B2 (OSRAM) |
| CN (2) | CN106456805B (OSRAM) |
| AU (2) | AU2015225499B2 (OSRAM) |
| CA (1) | CA2942166A1 (OSRAM) |
| WO (1) | WO2015134368A2 (OSRAM) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015134368A2 (en) * | 2014-03-03 | 2015-09-11 | Albert Einstein College Of Medicine Of Yeshiva University | Recombinant herpes simplex virus 2 (hsv-2) vaccine vectors |
| US10918712B2 (en) * | 2014-03-03 | 2021-02-16 | Albert Einstein College Of Medicine | Passive transfer of immunity using recombinant herpes simplex virus 2 (HSV-2) vaccine vectors |
| WO2019210219A1 (en) | 2018-04-27 | 2019-10-31 | Krystal Biotech, Inc. | Recombinant nucleic acids encoding cosmetic protein(s) for aesthetic applications |
| AU2019262056B2 (en) * | 2018-05-01 | 2025-10-02 | Albert Einstein College Of Medicine | HSV-2-delta-gD vaccines and methods for their production and use |
| WO2020056411A1 (en) * | 2018-09-14 | 2020-03-19 | Excell Biotech, Llc | Recombinant herpes simplex virus 1 (hsv-1) |
| CN112955175A (zh) * | 2018-10-17 | 2021-06-11 | 阿尔伯特爱因斯坦医学院 | 增强抗体依赖性细胞介导的细胞毒性（adcc）的方法 |
| KR102686042B1 (ko) * | 2019-01-03 | 2024-07-17 | 앨버트 아인슈타인 컬리지 오브 메디신 | 재조합 단순 헤르페스 바이러스 2 (hsv-2) 백신 벡터를 사용한 면역의 수동 전달 |
| CA3179416A1 (en) * | 2020-04-07 | 2021-10-14 | Albert Einstein College Of Medicine | Method of treating and preventing ocular disease with hsv-2 delta gd |
| KR20230044365A (ko) | 2020-05-29 | 2023-04-04 | 앨버트 아인슈타인 컬리지 오브 메디신 | HSV-2 단일 주기 바이러스 델타-gD 및 HSV-2 재조합 당단백질 D의 사용 방법 |
| KR20230074534A (ko) | 2020-09-24 | 2023-05-30 | 앨버트 아인슈타인 컬리지 오브 메디신 | Attb 세포주, 이로부터 유래된 유전자이식 세포주, 및 이를 제조하는 방법 |
| WO2023245159A1 (en) * | 2022-06-16 | 2023-12-21 | Albert Einstein College Of Medicine | Recombinant herpes simplex virus 2 (hsv-2) vectors and engineered transgenic vero cell lines |
| KR20250024845A (ko) * | 2022-08-05 | 2025-02-19 | 임비라 바이오파마수티컬스 컴퍼니 리미티드 | 복제 결함형 헤르페스 심플렉스 바이러스 1형바이러스 백신 |
| US20250222112A1 (en) * | 2022-10-14 | 2025-07-10 | Arizona Board Of Regents On Behalf Of Arizona State University | Recombinant immune complexes targeting herpes simplex virus |
| WO2025231288A2 (en) | 2024-05-01 | 2025-11-06 | Viradigm, Inc. | Hsv vectors having improved safety profiles |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT77014B (en) * | 1982-07-20 | 1986-01-24 | Molecular Genetics Inc | Production of herpes simplex viral proteins |
| NZ209308A (en) * | 1983-08-30 | 1991-08-27 | Genentech Inc | Vaccine against hsv involving a truncated membrane-free derivative of a membrane-bound protein |
| WO1987000862A1 (en) * | 1985-07-29 | 1987-02-12 | The Upjohn Company | Virus vaccine |
| US5646041A (en) * | 1987-02-12 | 1997-07-08 | Harfeldt; Elisabeth | Monoclonal antibody to herpes simplex virus and cell line producing same |
| EP0689603A1 (en) * | 1993-03-19 | 1996-01-03 | Cantab Pharmaceuticals Research Limited | Defective mutant non-retroviral virus (e.g. hsv) as vaccine |
| US20030083289A1 (en) * | 1995-10-19 | 2003-05-01 | Boursnell Michael Edward Griffith | Herpesvirus vectors and their uses |
| CN1120238C (zh) * | 1998-05-04 | 2003-09-03 | 本元正阳基因技术股份有限公司 | 以粘粒为基础构建重组单纯疱疹病毒及其用途 |
| ES2258987T3 (es) | 1999-12-17 | 2006-09-16 | Wyeth Holdings Corporation | Vacuna para reforzar las respuestas inmunitarias al virus del herpes simple. |
| WO2005005637A2 (en) * | 2003-05-09 | 2005-01-20 | Medigene, Inc. | Herpes simplex virus comprising a genetically modified glycoprotein d |
| US6984492B2 (en) * | 2003-09-05 | 2006-01-10 | Talecris Biotherapeutics, Inc. | Methods and compositions for treating herpes infections |
| WO2006004878A1 (en) * | 2004-06-29 | 2006-01-12 | Wyeth | Attenuated herpes simplex virus type-2, vectors thereof and immunogenic compositions thereof |
| CN101390099A (zh) | 2004-07-26 | 2009-03-18 | 皇家飞利浦电子股份有限公司 | 用于模拟执行可执行临床指引的决策支持系统 |
| US8865185B2 (en) * | 2006-09-08 | 2014-10-21 | The Trustees Of The University Of Pennsylvania | Methods of use for HSV-1 and HSV-2 vaccines |
| AU2007292905B2 (en) * | 2006-09-08 | 2013-05-23 | The Trustees Of The University Of Pennsyvania | HSV-1 and HSV-2 vaccines and methods of use thereof |
| WO2008085486A1 (en) * | 2006-12-28 | 2008-07-17 | The Trustees Of The University Of Pennsylvania | Herpes simplex virus combined subunit vaccines and methods of use thereof |
| JP5667880B2 (ja) * | 2008-01-03 | 2015-02-12 | コーネル リサーチ ファンデーション インコーポレイテッド | 原核生物におけるグリコシル化されたタンパク質の発現方法 |
| CN101288770A (zh) * | 2008-03-14 | 2008-10-22 | 浙江省医学科学院 | 新型单纯疱疹病毒ⅱ型dna疫苗 |
| ES2732815T3 (es) * | 2009-05-22 | 2019-11-26 | Genocea Biosciences Inc | Vacunas frente al virus del herpes simple de tipo 2: composiciones y métodos para provocar una respuesta inmunitaria |
| EP2477650B8 (en) * | 2009-09-18 | 2019-10-09 | FRAUNHOFER USA Inc. | Virus like particles comprising target proteins fused to plant viral coat proteins |
| WO2015134368A2 (en) | 2014-03-03 | 2015-09-11 | Albert Einstein College Of Medicine Of Yeshiva University | Recombinant herpes simplex virus 2 (hsv-2) vaccine vectors |
| US10918712B2 (en) | 2014-03-03 | 2021-02-16 | Albert Einstein College Of Medicine | Passive transfer of immunity using recombinant herpes simplex virus 2 (HSV-2) vaccine vectors |
-
2015
- 2015-03-02 WO PCT/US2015/018272 patent/WO2015134368A2/en not_active Ceased
- 2015-03-02 CN CN201580022222.6A patent/CN106456805B/zh active Active
- 2015-03-02 AU AU2015225499A patent/AU2015225499B2/en active Active
- 2015-03-02 JP JP2016555659A patent/JP6652497B2/ja active Active
- 2015-03-02 EP EP20195405.4A patent/EP3943106A1/en active Pending
- 2015-03-02 CN CN201911344961.3A patent/CN110938604B/zh active Active
- 2015-03-02 CA CA2942166A patent/CA2942166A1/en active Pending
- 2015-03-02 EP EP15758673.6A patent/EP3113801B1/en active Active
-
2016
- 2016-02-04 US US15/015,322 patent/US9999665B2/en active Active
-
2017
- 2017-03-10 US US15/455,495 patent/US10076568B2/en active Active
-
2018
- 2018-06-01 US US15/995,471 patent/US10391165B2/en active Active
-
2019
- 2019-07-30 US US16/526,056 patent/US10751411B2/en active Active
-
2020
- 2020-01-23 JP JP2020009043A patent/JP6844045B2/ja active Active
- 2020-08-10 AU AU2020217310A patent/AU2020217310B2/en active Active
- 2020-08-18 US US16/995,926 patent/US10980874B2/en active Active
-
2021
- 2021-02-24 JP JP2021026943A patent/JP7050193B2/ja active Active
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