JP2017509639A - 体重管理にシンナムアルデヒド及び亜鉛を用いるための方法及び組成物 - Google Patents
体重管理にシンナムアルデヒド及び亜鉛を用いるための方法及び組成物 Download PDFInfo
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- JP2017509639A JP2017509639A JP2016557635A JP2016557635A JP2017509639A JP 2017509639 A JP2017509639 A JP 2017509639A JP 2016557635 A JP2016557635 A JP 2016557635A JP 2016557635 A JP2016557635 A JP 2016557635A JP 2017509639 A JP2017509639 A JP 2017509639A
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- cinnamaldehyde
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- zinc
- weight loss
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Abstract
Description
アルコール飲料:498.8ppmまで、例えば、約435.6ppmなど。
焼成製品:367.4ppmまで、例えば、約273.8ppmなど。
チューインガム:6191.0ppmまで、例えば、約1533.0ppmなど。
調味料又は薬味:31.87ppmまで、例えば、約17.48ppmなど。
冷凍乳製品:77.96ppmまで、例えば、約72.98ppmなど。
フルーツアイス:900.0ppmまで、例えば、約900.0ppmなど。
ゼラチン又はプディング:109.4ppmまで、例えば、約100.3ppmなど。
グレービーソース:800.0ppmまで、例えば、約640.0ppmなど。
ハードキャンディ:1003.0ppmまで、例えば、約792.2ppmなど。
肉製品:39.09ppmまで、例えば、約6.97ppmなど。
非アルコール飲料:67.82ppmまで、例えば、約52.71ppmなど。
ソフトキャンディ:370.0ppmまで、例えば、約370.0ppmなど。
[0061]以下の非限定的な実施例は、許容できない味覚又は胃腸への影響を与えることなく、エネルギー消費、交感神経系の活性、又は脂肪の酸化のうち少なくとも1つを増大するために、シンナムアルデヒド及び亜鉛の組み合わせをTRPA1の相乗的な活性化を目的として投与するという概念を発展及び支持する科学的データを示す。
[0063]ヒト被験者に、プラシーボ、清涼香味剤、カプサイシン、又はシンナムアルデヒドが投与された。エネルギー消費が、摂取後80分間にわたり測定された。図3は、種々の化合物摂取後の、経過時間の関数として表されるエネルギー消費のグラフである。図4は、種々の化合物摂取後の、AUCに基づくエネルギー消費のグラフである。図3及び4は、シンナムアルデヒド摂取後に、プラシーボに比べエネルギー消費が増大することを示している。
[0069]ヒト被験者に、4.8ppmのカプサイシン又は350ppmのシンナムアルデヒドを含む組成物を投与した。図9は、比較味覚試験結果のグラフを示す。参加者の87.9%が、カプサイシン強度を非常に強いと判定したのに対し、シンナムアルデヒドに関しては、わずか20.5%であった。カプサイシン及びシンナムアルデヒドによって脂肪の酸化に対し同様の効果を達成するためには、カプサイシンの用量は香味剤として使用できる最大量(Fenaroli’s Handbook:Burdock,2010によると7ppm)の約1.5分の1であり、シンナムアルデヒドの用量は香味剤として使用できる最大量(Fenaroli’s Handbook:Burdock,2010によると6191.0ppm)の約17.5分の1である。
[0071]試験管内で、10μMシンナムアルデヒド及び0.3μM亜鉛、並びにこれらの組み合わせのそれぞれについて、CHO細胞のhTRPA1発現活性を測定した。結果は図10に表されており、シンナムアルデヒド及び亜鉛を組み合わせた場合(Cin+Zinc)の相乗効果が示されている。C+はこの試験における実験上の陽性対照を表しており、用量反応曲線により最大効果を与える50mMのシンナムアルデヒドである。
Claims (15)
- 体重維持を必要とする個体にシンナムアルデヒド及び亜鉛を含む組成物を投与することを含む、体重維持のための方法。
- 前記シンナムアルデヒドが、安全で摂取に耐えられる量であり、かつ前記亜鉛との組み合わせにより、エネルギー消費、交感神経系の活性、及び脂肪の酸化からなる群から選択される少なくとも1つの特性を増大するのに有効な量で、前記組成物中に存在する、請求項1に記載の方法。
- 前記組成物が、前記シンナムアルデヒドの少なくとも一部を供給する桂皮精油抽出物を含む、請求項1に記載の方法。
- 前記シンナムアルデヒドの少なくとも一部が、単離シンナムアルデヒド及び合成シンナムアルデヒドからなる群から選択される、請求項1に記載の方法。
- 減量を必要とする個体にシンナムアルデヒド及び亜鉛を含む組成物を投与することを含む、減量を促進するための方法。
- 肥満又は体重過多の危険を有する個体にシンナムアルデヒド及び亜鉛を含む組成物を投与することを含む、肥満又は体重過多を予防するための方法。
- 治療上有効な量のシンナムアルデヒド及び亜鉛を含む組成物を肥満個体に投与することを含む、肥満を治療するための方法。
- シンナムアルデヒド及び亜鉛を含む、減量用組成物。
- 前記シンナムアルデヒドが、安全で摂取に耐えられる量であり、かつ前記亜鉛との組み合わせにより、エネルギー消費、交感神経系の活性、及び脂肪の酸化からなる群から選択される少なくとも1つの特性を増大するのに有効な量で、前記組成物中に存在する、請求項8に記載の組成物。
- 前記組成物が、前記シンナムアルデヒドが31.87ppm〜6191ppmの香味付け濃度で存在する食品製品である、請求項8に記載の組成物。
- 前記組成物が、シンナムアルデヒド:亜鉛の比が1:0.5〜1:0.005の食品製品である、請求項8に記載の組成物。
- 前記組成物が、体重維持又は減量を促進するために治療上有効な量の追加の成分を更に含む、請求項8に記載の組成物。
- シンナムアルデヒド及び亜鉛を含む組成物を、減量プログラムを実施中の個体に投与することを含む、減量を促進するための方法。
- 前記減量プログラムが、低脂肪食、低炭水化物食、低カロリー食、超低カロリー食、持久力トレーニング、筋力トレーニング、及びこれらの組み合わせからなる群から選択される、請求項13に記載の方法。
- タンパク質、炭水化物、脂肪、及びこれらの組み合わせからなる群から選択される構成成分に、シンナムアルデヒド及び亜鉛を添加することを含む、減量用食品製品を製造する方法。
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PCT/EP2015/054916 WO2015140002A1 (en) | 2014-03-20 | 2015-03-10 | Methods and compositions for using cinnamaldehyde and zinc for weight management |
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