JP2017501749A5 - - Google Patents
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- Publication number
- JP2017501749A5 JP2017501749A5 JP2016563876A JP2016563876A JP2017501749A5 JP 2017501749 A5 JP2017501749 A5 JP 2017501749A5 JP 2016563876 A JP2016563876 A JP 2016563876A JP 2016563876 A JP2016563876 A JP 2016563876A JP 2017501749 A5 JP2017501749 A5 JP 2017501749A5
- Authority
- JP
- Japan
- Prior art keywords
- host cell
- ornithine
- recombinant protein
- culture medium
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461926481P | 2014-01-13 | 2014-01-13 | |
| US61/926,481 | 2014-01-13 | ||
| PCT/US2014/069378 WO2015105609A1 (en) | 2014-01-13 | 2014-12-09 | Regulating ornithine metabolism to manipulate the high mannose glycoform content of recombinant proteins |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017501749A JP2017501749A (ja) | 2017-01-19 |
| JP2017501749A5 true JP2017501749A5 (https=) | 2017-12-07 |
| JP6732660B2 JP6732660B2 (ja) | 2020-07-29 |
Family
ID=52273554
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016563876A Active JP6732660B2 (ja) | 2014-01-13 | 2014-12-09 | 組換えタンパク質の高マンノースグリコフォーム含有量を操作するためのオルニチン代謝の調節 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US10513723B2 (https=) |
| EP (1) | EP3094735A1 (https=) |
| JP (1) | JP6732660B2 (https=) |
| KR (1) | KR102381791B1 (https=) |
| CN (2) | CN106029896B (https=) |
| AU (3) | AU2014376225C1 (https=) |
| BR (2) | BR122020004385B1 (https=) |
| CA (1) | CA2936104C (https=) |
| CL (3) | CL2016001786A1 (https=) |
| EA (2) | EA039141B1 (https=) |
| IL (1) | IL246727B (https=) |
| MX (2) | MX384153B (https=) |
| SG (2) | SG10201806643WA (https=) |
| WO (1) | WO2015105609A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR095196A1 (es) | 2013-03-15 | 2015-09-30 | Regeneron Pharma | Medio de cultivo celular libre de suero |
| TWI870789B (zh) | 2015-08-04 | 2025-01-21 | 美商再生元醫藥公司 | 補充牛磺酸之細胞培養基及用法 |
| BR112020000127A2 (pt) * | 2017-07-06 | 2020-07-07 | Regeneron Pharmaceuticals, Inc. | método para selecionar um hidrolisado de soja, e, glicoproteína |
| RU2672318C1 (ru) * | 2017-09-19 | 2018-11-13 | Общество с ограниченной ответственностью "Международный Биотехнологический Центр "Генериум" | Способ получения моноклональных антител терапевтического назначения с помощью непрерывного культивирования клеток сно |
| AU2018392658B2 (en) | 2017-12-20 | 2024-07-25 | Ares Trading S.A. | Methods for modulating protein mannosylation profiles using maduramycin, narasin, or salinomycin |
| US12297451B1 (en) | 2019-10-25 | 2025-05-13 | Regeneron Pharmaceuticals, Inc. | Cell culture medium |
| CN111671051B (zh) * | 2020-07-30 | 2022-01-11 | 广州同康生物科技有限公司 | 一种整粒黄豆中嘌呤的脱除工艺 |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6936694B1 (en) | 1982-05-06 | 2005-08-30 | Intermune, Inc. | Manufacture and expression of large structural genes |
| AU588819B2 (en) | 1984-10-29 | 1989-09-28 | Immunex Corporation | Cloning of human granulocyte-macrophage colony stimulating factor gene |
| US4968607A (en) | 1987-11-25 | 1990-11-06 | Immunex Corporation | Interleukin-1 receptors |
| US5075222A (en) | 1988-05-27 | 1991-12-24 | Synergen, Inc. | Interleukin-1 inhibitors |
| AU643427B2 (en) | 1988-10-31 | 1993-11-18 | Immunex Corporation | Interleukin-4 receptors |
| US5395760A (en) | 1989-09-05 | 1995-03-07 | Immunex Corporation | DNA encoding tumor necrosis factor-α and -β receptors |
| EP0939121B2 (de) | 1989-09-12 | 2007-12-26 | AHP Manufacturing B.V. | TFN-bindende Proteine |
| US6204363B1 (en) | 1989-10-16 | 2001-03-20 | Amgen Inc. | Stem cell factor |
| US5149792A (en) | 1989-12-19 | 1992-09-22 | Amgen Inc. | Platelet-derived growth factor B chain analogs |
| US5272064A (en) | 1989-12-19 | 1993-12-21 | Amgen Inc. | DNA molecules encoding platelet-derived growth factor B chain analogs and method for expression thereof |
| US5350683A (en) | 1990-06-05 | 1994-09-27 | Immunex Corporation | DNA encoding type II interleukin-1 receptors |
| WO1991018982A1 (en) | 1990-06-05 | 1991-12-12 | Immunex Corporation | Type ii interleukin-1 receptors |
| PT672141E (pt) | 1992-10-23 | 2003-09-30 | Immunex Corp | Metodos de preparacao de proteinas oligomericas soluveis |
| US5554512A (en) | 1993-05-24 | 1996-09-10 | Immunex Corporation | Ligands for flt3 receptors |
| US5981713A (en) | 1994-10-13 | 1999-11-09 | Applied Research Systems Ars Holding N.V. | Antibodies to intereleukin-1 antagonists |
| US5721121A (en) | 1995-06-06 | 1998-02-24 | Genentech, Inc. | Mammalian cell culture process for producing a tumor necrosis factor receptor immunoglobulin chimeric protein |
| DK1666591T3 (da) | 1995-06-29 | 2011-05-23 | Immunex Corp | Cytokin der inducerer apoptose |
| US6613544B1 (en) | 1995-12-22 | 2003-09-02 | Amgen Inc. | Osteoprotegerin |
| US6096728A (en) | 1996-02-09 | 2000-08-01 | Amgen Inc. | Composition and method for treating inflammatory diseases |
| US6271349B1 (en) | 1996-12-23 | 2001-08-07 | Immunex Corporation | Receptor activator of NF-κB |
| US6235883B1 (en) | 1997-05-05 | 2001-05-22 | Abgenix, Inc. | Human monoclonal antibodies to epidermal growth factor receptor |
| US6337072B1 (en) | 1998-04-03 | 2002-01-08 | Hyseq, Inc. | Interleukin-1 receptor antagonist and recombinant production thereof |
| AU1920301A (en) | 1999-11-17 | 2001-05-30 | Immunex Corporation | Receptor activator of nf-kappa b |
| US6544424B1 (en) | 1999-12-03 | 2003-04-08 | Refined Technology Company | Fluid filtration system |
| CN101255192A (zh) | 2000-05-26 | 2008-09-03 | 布里斯托尔-迈尔斯斯奎布公司 | 可溶性ctla4突变体分子及其应用 |
| US20030104996A1 (en) * | 2001-08-30 | 2003-06-05 | Tiansheng Li | L-methionine as a stabilizer for NESP/EPO in HSA-free formulations |
| US8053238B2 (en) | 2005-10-31 | 2011-11-08 | Unhwa Corporation | Isolated population of plant single cells and method of preparing the same |
| US20070190057A1 (en) * | 2006-01-23 | 2007-08-16 | Jian Wu | Methods for modulating mannose content of recombinant proteins |
| WO2008154014A2 (en) * | 2007-06-11 | 2008-12-18 | Amgen Inc. | A method for culturing mammalian cells to improve recombinant protein production |
| WO2012145682A1 (en) | 2011-04-21 | 2012-10-26 | Amgen Inc. | A method for culturing mammalian cells to improve recombinant protein production |
| PT2837680T (pt) | 2011-07-01 | 2020-04-17 | Amgen Inc | Cultura celular de mamífero |
-
2014
- 2014-12-09 BR BR122020004385-7A patent/BR122020004385B1/pt active IP Right Grant
- 2014-12-09 KR KR1020167021677A patent/KR102381791B1/ko active Active
- 2014-12-09 MX MX2020000963A patent/MX384153B/es unknown
- 2014-12-09 CA CA2936104A patent/CA2936104C/en active Active
- 2014-12-09 US US15/111,470 patent/US10513723B2/en active Active
- 2014-12-09 JP JP2016563876A patent/JP6732660B2/ja active Active
- 2014-12-09 CN CN201480073081.6A patent/CN106029896B/zh active Active
- 2014-12-09 EP EP14821407.5A patent/EP3094735A1/en active Pending
- 2014-12-09 CN CN202011124768.1A patent/CN112481337B/zh active Active
- 2014-12-09 WO PCT/US2014/069378 patent/WO2015105609A1/en not_active Ceased
- 2014-12-09 SG SG10201806643WA patent/SG10201806643WA/en unknown
- 2014-12-09 MX MX2016009084A patent/MX376230B/es active IP Right Grant
- 2014-12-09 SG SG11201605640UA patent/SG11201605640UA/en unknown
- 2014-12-09 BR BR112016015797-4A patent/BR112016015797B1/pt active IP Right Grant
- 2014-12-09 EA EA201691426A patent/EA039141B1/ru unknown
- 2014-12-09 EA EA202191909A patent/EA202191909A1/ru unknown
- 2014-12-09 AU AU2014376225A patent/AU2014376225C1/en active Active
-
2016
- 2016-07-12 CL CL2016001786A patent/CL2016001786A1/es unknown
- 2016-07-12 IL IL246727A patent/IL246727B/en active IP Right Grant
-
2018
- 2018-09-04 AU AU2018226416A patent/AU2018226416C1/en active Active
- 2018-09-06 CL CL2018002548A patent/CL2018002548A1/es unknown
-
2019
- 2019-11-06 US US16/676,340 patent/US11254963B2/en active Active
-
2020
- 2020-10-28 AU AU2020260443A patent/AU2020260443B2/en active Active
-
2022
- 2022-02-25 CL CL2022000470A patent/CL2022000470A1/es unknown
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