JP2017193512A - Foaming tablet for oral cleaning - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a foaming tablet for oral cleaning in which the volume of a foaming agent upon foaming is appropriate so that the agent sufficiently spreads around and between the teeth and the tongue to provide a required cleaning effect with a volume at a level preventing, as much as possible, recognition of its presence in the mouth.SOLUTION: The foaming tablet for oral cleaning is obtained by forming a mixture into a tablet, the mixture comprising: a tablet base material comprising a material containing crystalline cellulose; a foaming agent containing sodium bicarbonate; and a polishing agent containing silicic anhydride. The foaming agent is made to have such a weight that the volume of the foaming agent upon foaming is 26 milliliters or more and 53 milliliters or less.SELECTED DRAWING: Figure 1

Description

  The present invention relates to an effervescent tablet for oral cleaning.

  Effervescent tablets for oral cleaning (hereinafter sometimes referred to simply as “tablets”) are foamed by contact with saliva from the foaming agent contained in the tablet in the mouth, and the active ingredients of the tablet (abrasives, tooth protection) Agent etc.) is able to reach the mouth and clean the mouth with foam.

  For example, Patent Document 1 discloses such an effervescent tablet for oral cleaning. The mouth-cleaning effervescent tablet disclosed in the literature comprises a predetermined weight% of a base material such as crystalline cellulose, a foaming agent such as sodium bicarbonate, an abrasive, a tooth protecting agent, an additive for flavoring, and the like. (See Patent Document 1).

Special Table 2002-53480

  By the way, the foaming agent contained in the foamable tablet for oral cleaning needs to occupy a certain volume at the time of foaming so that the necessary cleaning effect can be obtained by adequately spreading around the teeth and tongue. is there. However, on the other hand, these tablets can be used so as not to let others know that they are contained in the mouth as soon as possible, for example, just before meeting a person on the go, and there is no need to exhale foam after use. There is also a need to keep garbage out. However, if the volume of the foaming agent contained in the tablet is enough to fill the mouth, it will be noticeable that it is contained in the mouth, and bubbles will accumulate in the mouth even after cleaning, and it will be necessary to exhale this It becomes difficult to satisfy the above-mentioned needs. Therefore, in this type of tablet, the volume at the time of foaming is not too small and not too large, and is required to have an appropriate volume.

  In addition, for physically handicapped people and elderly people who are handicapped, it may be difficult to brush their teeth because they cannot move their hands freely. In such a case, there is a high need for a tablet that does not require a toothbrush or water and that can be simply cleaned by simply placing it in the mouth. At that time, particularly elderly people may accidentally swallow the foam, and if the volume of the foam is large, there is a risk that the foam may enter the lungs and cause pneumonia. In order to prevent this, it is desirable to prevent the foam volume from becoming excessive and to reduce the risk of swallowing the foam so that it can be cleaned while facing downward. In this respect, if it is difficult to perform the operation with the mouth completely closed as in a normal toothbrushing operation, it is difficult to clean downward. If it is a tablet, it can be cleaned (moving the mouth) with the mouth completely closed, but if the foam volume is too large, the mouth is completely closed and this action is performed. It becomes difficult.

  In addition, when the evacuation life associated with a large-scale disaster has not been able to use enough water for a long time and toothpaste etc. have been insufficient for a long time, the physical strength of the elderly, especially the elderly, has not been kept clean. It has been pointed out that people who have decreased are prone to pneumonia. Therefore, from this point of view, the importance of effervescent tablets for oral cleaning that can be taken without water and can be adequately foamed to obtain a sufficient cleaning effect is increasing. I can say that.

  However, heretofore, there has not been an effervescent tablet for oral cleaning that is configured so that the volume of the foaming agent at the time of foaming becomes an appropriate volume. Patent Document 1 describes that 10 to 50% by weight of a foaming agent selected from the group consisting of sodium bicarbonate, ammonium bicarbonate, potassium bicarbonate, iron carbonate, and mixtures thereof is included. (Refer to claim 1), and an example in which the weight of the tablet is 700 milligrams is described (see the specification [0026]), so calculate the volume of foaming agent assumed in the tablet at the time of foaming However, this document does not change the idea that the volume of the foaming agent at the time of foaming is an appropriate volume.

  The present invention has been made in view of the above-mentioned problems. The problem to be solved is that the volume of the foaming agent at the time of foaming is adequate, i.e., the gap between the teeth and the tongue is sufficient and the required cleaning is performed. An object of the present invention is to provide a mouth-cleaning effervescent tablet that is configured to have a volume that does not make it possible to know that it is contained in the mouth as much as possible while obtaining the effect.

  In order to solve the above problems, among the present inventions, the first invention is a mixture comprising a tablet substrate made of a material containing crystalline cellulose, a foaming agent containing sodium hydrogencarbonate, and an abrasive containing anhydrous silicic acid. A foamable tablet for oral cleaning, wherein the foaming agent has a volume of 26 to 53 milliliters of foaming agent at the time of foaming.

  The second invention is based on the first invention, and the blowing agent is any one or more of sodium hydrogen carbonate, magnesium hydride, calcium hydride and sodium aluminum hydride, and the total weight is 0. Provided is an effervescent tablet for oral cleaning that is 2 grams or more and 0.4 grams or less.

  Moreover, 3rd invention is based on 1st or 2nd invention, The said base material for tablets is foamability for oral cleansing whose volume is 1/1500 or more and 2/1500 of the volume at the time of foaming of a foaming agent. Provide tablets.

  The fourth invention is based on any one of the first to third inventions, and provides an effervescent tablet for oral cleaning in which the tablet base material has an average particle size of 50 microns to 100 microns. To do.

  Moreover, 5th invention provides the foamable tablet for oral cleaning whose average particle diameter is 10 micrometers or more and 30 microns or less on the basis of any one invention of 1st to 4th.

  Moreover, 6th invention provides the foamable tablet for oral cleansing whose surface roughness is 100 micron or more and 300 micron or less in arithmetic mean roughness based on any one invention from 1st to 5th.

  Further, the seventh invention is based on any one of the first to sixth inventions, and the dosage form is a substantially cylindrical shape having upper and lower surfaces having a substantially convex lens shape, and the height corresponding to the optical axis direction is 5 mm or more. Provided is an effervescent tablet for oral cleaning having a length equal to or less than millimeters, a length corresponding to a lens diameter of 12 mm to 14 mm, and a height corresponding to a cylindrical side surface of 3 mm to 4 mm.

  The eighth invention is based on the seventh invention, and the surface roughness of the substantially cylindrical side surface is lower than the surface roughness of the upper and lower surfaces of the substantially convex lens shape. Provide tablets.

  The ninth invention is a packaging tablet comprising a foamable tablet for oral cleaning according to any one of the first to eighth inventions and a container for packaging the tablet, and the packaging is a press-through pack. There is provided a packaged tablet made of an uncolored aluminum alloy foil with a planned crushing surface in contact with the tablet.

  The tenth invention provides a wrapping tablet whose press surface is a transparent plastic material on the basis of the ninth invention.

  The eleventh invention provides a packaged tablet in which the press-through pack is in a sheet form that can be separated by a set of three tablets on the basis of the ninth or tenth invention.

  A twelfth aspect of the invention provides a packaging tablet in which a press-through pack is provided with a rib for preventing sheet bending deformation, based on any one of the ninth to eleventh aspects of the invention.

  According to the present invention, the volume of the foaming agent at the time of foaming is adequate, i.e., it can be sufficiently distributed around the teeth and tongues to obtain the required cleaning effect, while being contained in the mouth as much as possible. It is possible to provide an effervescent tablet for oral cleaning configured to have a volume that is not known.

The figure which shows an example of the shape of the foamable tablet for oral cleaning of Example 7. The figure which shows an example of the external appearance of the packaging tablet of Example 9 The figure which shows an example of the external appearance of the packaging tablet of Example 10. The figure which shows an example of the external appearance of the packaging tablet of Example 11

0110, 0210 Foamable tablet for oral cleaning 0111 Upper surface 0112 Lower surface 0113 Optical axis direction equivalent height 0114 Lens diameter equivalent length 0115 Cylindrical side surface 0116 Cylindrical side surface equivalent height 0200 Packaging tablet 0220 Packaging 0221 Sheet 0222 Cover 0223 Scheduled to crush Surface 0224 Housing 0325 Perforation 0435 Rib

  Examples of the present invention will be described below. The relationship between the embodiments and the claims is as follows. Example 1 mainly relates to claim 1 etc. Example 2 mainly relates to claim 2 etc. Example 3 mainly relates to claim 3 etc. Example 4 mainly relates to claim 4 etc. 5 mainly relates to claim 5 etc. Example 6 mainly relates to claim 6 etc. Example 7 mainly relates to claim 7 etc. Example 8 mainly relates to claim 8 etc. Example 9 The tenth embodiment mainly relates to the ninth and tenth claims, the tenth embodiment mainly relates to the eleventh embodiment, and the eleventh embodiment mainly relates to the twelfth embodiment. In addition, this invention is not limited to these Examples at all, and can be implemented in various modes without departing from the gist thereof.

<Overview>
The effervescent tablet for oral cleaning of this example contains a foaming agent containing sodium hydrogencarbonate, and the volume of the foaming agent at the time of foaming is adequate, that is, the gap around the teeth and tongue is sufficient. While the required cleaning effect can be obtained, the volume is such that it is as small as possible that it is not contained in the mouth.

<Configuration>
(General) In Table 1, it shows about an example of a structure of the foamable tablet for oral cleaning of a present Example. As shown in this table, the foamable tablet for oral cleaning of this example includes (1) a tablet substrate, (2) a foaming agent, (3) an abrasive, and the like. In addition, citric acid (C ₆ H ₈ O ₇ ) (also has an effect of promoting saliva secretion) and xylitol (C ₅ H ₁₂ O ₅ ) (also has a role as a tooth protectant) for the purpose of giving a refreshing feeling. , And may contain peppermint. Furthermore, a small amount of cetylpyridinium chloride (C ₂₁ H ₃₈ NCl) (which has an effect of sterilizing periodontal disease and caries causing bacteria and preventing periodontal disease and dental caries), aspartame (C ₁₄ H ₁₈ N ₂ O ₅₎ (sweetener), L-menthol _{(C 10 H} 20 O) (flavoring agents), it may contain vitamin C. May further contain allantoin _{(C 4 H 6 N 4 O} 3). Allantoin is said to have an effect of activating gingival cells to prevent periodontal disease and a whitening effect. Note that fluorine or a fluorinated compound may be included as a tooth protecting agent, but it is desirable that no fluorine or fluorinated compound be included because there is a possibility of having a toxic effect on the human body. With these components, the effervescent tablet for oral cleaning according to the present example has a cleaning effect in the oral cavity, prevention of periodontal disease (alveolar pyorrhea), prevention of gingivitis, prevention of occurrence and progression of dental caries, Furthermore, effects such as prevention of bad breath, whitening (whitening teeth), and imparting a refreshing feeling in the oral cavity can be achieved.

(Tablet base material)
In addition to serving as a binder that binds foaming agents, abrasives, etc., the tablet substrate serves as an excipient for molding the entire mixture containing these into a size and shape that is easy to take. It is what is added. For example, crystalline cellulose ((C ₆ H ₁₀ O ₅ ) _n ) is used as the raw material for the tablet substrate. Since crystalline cellulose is hard, it has an advantage that it is easy to mold a tablet, and it is easy to feel good mouthfeel when it is contained in the mouth.

(Foaming agent: general)
A foaming agent is added in order to produce foam by contact with saliva. The feature of the present invention is that the weight of the foaming agent contained in the tablet is adjusted so that the volume of the foaming agent when foamed becomes an appropriate volume. Here, an appropriate volume means a volume that is sufficient to get around the gaps around the teeth and tongue to obtain the required cleaning effect, but it is not understood that it is contained in the mouth as much as possible, and it is erroneous. The volume is suppressed to such a level that there is no risk of causing pneumonia if swallowed. Specifically, the volume is 26 ml or more and 53 ml or less when foaming. More preferably, it means a volume of 26 ml or more and 40 ml or less at the time of foaming.

(Foaming agent: volume when foaming)
In the present invention, the reason why the volume of the foaming agent at the time of foaming is “26 ml or more and 53 ml or less” is as follows.

Table 2 shows Kenji Mogi et al. “Study of a new method for measuring intraoral volume as an oral function test” (North Kanto Medicine Vol. 50 (2000) No. 6 P511-516, hereinafter referred to as “Non-Patent Document 1”). It is the data regarding the intraoral volume of the healthy person disclosed by 1).

  The above data is obtained by measuring the intraoral volume of a person by a method called a hydrous method. The water-containing method is a method in which the tip of a 60 ml syringe filled with water is inserted into the oral cavity through the mouth angle of the subject, water in the syringe is injected, the maximum value is recorded, and the average value of six times Is assumed to be the volume in the oral cavity.

  In Table 2 above, as data based on the measurement results for 10 healthy subjects, the data of the closed position (measured at the central occlusal position) and the open position (measured with the jaw position freely set) are provided. However, according to Non-Patent Document 1, it is said that the closed position data is less repetitive and more reproducible. Therefore, when the average value of the intraoral volume in the closed position of all the subjects is calculated from the table, the value is 61.4 ml. According to Non-Patent Document 1, the average values of the subject's height, maximum head length, zygomatic arch width, and total head height are 164 centimeters, 17.8 centimeters, 14.0 centimeters, 23. 6 centimeters, and a positive correlation is observed between these and the oral volume.

  According to a rule of thumb, when a person has a bubble in his mouth, the volume of the mouth is sufficient to spread all over the mouth and not enough to chew the mouth. The product is considered to be about 2/5 to 4/5, and more preferably about 2/5 to 3/5 of the oral volume. This is because it has enough volume in its mouth (which can be found, for example, by filling the mouth with air or water and exhaling it and measuring its volume) It is possible to know by measuring the volume when the mouth contains an amount of gas that is not enough to fill the mouth and comparing the volume of both. Then, the ratio based on this empirical rule is applied to the data (61.4 ml) of the average oral cavity volume disclosed in Non-Patent Document 1, and foaming at the time of foaming of the foamable tablet for oral cleaning of the present invention. The volume of the agent was 26 ml or more and 53 ml or less. Further, the foaming agent at the time of foaming the foamable tablet for oral cleaning corresponding to a more suitable volume in which the volume of the foam in the oral cavity is about 2/5 to 3/5 of the oral cavity volume is more preferable. The volume was 26 ml or more and 40 ml or less.

  As is clear from the description of Non-Patent Document 1, the intraoral volume has a positive correlation with the values of human height, maximum head length, zygomatic arch width or total head height. It is recognized that the oral volume is larger than that of women, and that of adults is larger than that of children. Therefore, in the foamable tablet for cleaning the mouth according to the present invention, the volume of foaming agent at the time of foaming may be made different depending on these distinctions after being distinguished for adult men, adult women, children, etc. Good. For example, in Table 2, taking into account that the average value of the oral volume in the closed position of the male subject is 74.0 ml, and the average value of the oral volume in the closed position of the female subject is 42.5 ml, The foaming volume of the foaming agent for oral cleaning for adult men is from 32 ml to 64 ml, and the foaming volume of the foaming agent for oral cleaning for adult women is from 18 ml to 36 ml. It is good also as follows. Moreover, it is good also considering the volume at the time of foaming of the foaming agent of the foamable tablet for oral cleaning for children as an appropriate numerical value in the range of about 5-35 milliliters according to age.

<Manufacturing method>
The effervescent tablet for oral cleaning of a present Example can be manufactured using a well-known method. For example, Patent Document 1 described above discloses a method for producing an effervescent tablet for oral cleaning comprising (1) a premixing step, (2) a mixing step, and (3) a tableting step. Here, the premixing step is a step of adsorbing a solution prepared by adding a colorant to distilled water to a mixture (including crystalline cellulose) and drying to obtain a preliminarily adjusted product. The mixing step is a premixing step. Step of obtaining a mixture by adding a foaming agent, an abrasive, a tooth protecting agent, a sweetener and the like to the pre-adjusted product obtained in the step). The tableting step is a step of tableting the mixture obtained in the mixing step (see Patent Document 1). The effervescent tablet for oral cleaning of a present Example can also be manufactured by the method similar to this.

<Effect>
According to the present embodiment, the foaming agent at the time of foaming has an appropriate volume, i.e., sufficiently spread around the teeth and tongues to obtain the required cleaning effect, but is contained in the mouth as much as possible. It is possible to provide an effervescent tablet for oral cleaning that is configured to have a volume that does not allow understanding.

<Overview>
In the foamable tablet for oral cleaning of this example, the foaming agent is one or more of sodium hydrogen carbonate, magnesium hydride, calcium hydride and sodium aluminum hydride, and the total weight is 0.2 g or more and 0.00. 4 grams or less.

<Configuration>
(General)
In Table 3, it shows about an example of a structure of the foamable tablet for oral cleaning of a present Example. In the table, the weight (mass) of one tablet is 822.34 milligrams, and in this case, the weight of the tablet substrate, foaming agent, abrasive, etc. contained in the proportion (mass%) shown in Table 1 respectively. Indicated. The weight of 822.34 milligrams of one tablet is an example of a weight suitable for obtaining a size and shape that can be easily taken. For example, a tablet having such a weight has a diameter of 13 millimeters and a thickness of 3.5 millimeters. Can be formed into a disk shape. Details of the lock shape will be described later in another embodiment.

(Foaming agent: weight)
The tablet of this example is basically the same as the tablet of Example 1, but the foaming agent is sodium bicarbonate (NaHCO ₃ ), magnesium hydride (MgH ₂ ), calcium hydride (CaH ₂ ), aluminum hydride. It is one or more of sodium (NaAlH ₄ ), and is characterized in that the total weight is 0.2 g or more and 0.4 g or less.

  In the above Table 3, as an example when the total weight of the foaming agent is 0.2 g or more and 0.4 g or less, only sodium bicarbonate is included as the foaming agent, and the weight is 256 milligrams (0. 256 grams) is shown. In this example, the ratio (mass%) of sodium hydrogen carbonate contained in one tablet (weight 822.34 mg) was 31.1%, which is the ratio of the foaming agent shown in Table 1 to the whole tablet. It corresponds.

  For example, when only sodium hydrogen carbonate is included as a foaming agent and the volume at the time of foaming is 26 milliliters, the weight of the foaming agent is 0.2 grams. This is derived from the following relationship.

When sodium hydrogen carbonate is brought into contact with saliva, carbon dioxide is generated by the chemical reaction shown in Chemical Formula 1 (Chemical Formula 1), and this is almost the volume when the foaming agent is foamed.
(Chemical formula 1)
2NaHCO ₃ → Na ₂ CO ₃ + H ₂ O + CO ₂

  Here, since the molecular weight of sodium hydrogen carbonate is 84, 1 mol of carbon dioxide (volume: 22.4 liters) is generated from 168 grams of sodium hydrogen carbonate. Therefore, the weight of sodium hydrogen carbonate for generating 26 milliliters of carbon dioxide by this reaction is 0.2 grams (≈168 × 26/22400). Since it can be said that the volume at the time of foaming of sodium hydrogen carbonate is almost equal to the volume of carbon dioxide, the weight of sodium hydrogen carbonate at which the volume at the time of foaming is 26 ml is 0.2 g. Further, according to the same calculation, the weight of sodium hydrogen carbonate for generating 53 milliliters of carbon dioxide is 0.4 grams. The weight of sodium hydrogen carbonate for generating 40 milliliters of carbon dioxide is 0.3 grams. That is, in the tablet of this example, when the size of the tablet is suitable for taking, the foaming amount of the foaming agent is adequately distributed, that is, the necessary amount of the foam around the teeth and tongue. While the cleaning effect can be obtained, the weight is adjusted so that the volume is as small as possible not to be included in the mouth.

Magnesium hydride (MgH ₂ , molecular weight 26.3), calcium hydride (CaH ₂ , molecular weight 42.0), sodium aluminum hydride (NaAlH ₄ , molecular weight 54.0) It is a hydrogen generator that is generated. For example, the chemical formula for generating hydrogen from magnesium hydride is as shown in the following chemical formula 2 (Chemical formula 2).
(Chemical formula 2)
MgH ₂ + 2H ₂ O → Mg (OH) ₂ + 2H ₂

  The weight of these foaming agents necessary for generating a predetermined volume of hydrogen can be determined by the same calculation as shown above for sodium hydrogen carbonate, so that the volume during foaming is 26 ml or more and 53 ml. The weight of each foaming agent when sodium bicarbonate, magnesium hydride, calcium hydride, sodium aluminum hydride, or all or part thereof are combined can be determined as follows. For example, if the tablet contains 0.2 grams of sodium bicarbonate and 0.01 grams of magnesium hydride as a foaming agent, the volume when foamed is about 35 milliliters (carbon dioxide 26.7 milliliters, hydrogen 8.5 milliliters). Can be obtained.

  Hydrogen is said to have an excellent effect on health and beauty because it binds to active oxygen having an action of promoting aging of the body and neutralizes this to remove the action. Therefore, by including a hydrogen generating agent such as magnesium hydride, calcium hydride, or sodium aluminum hydride as a foaming agent for the foamable tablet for oral cleaning of the present example, such effects on health and beauty can be expected. In addition, hydrogen also has a bactericidal action, and a tablet containing a hydrogen generator can be expected to have an effect of sterilizing periodontal diseases in the oral cavity and causative bacteria of dental caries.

  Also in this example, as in the previous example, the foaming agent has a variation in weight so that the volume of the foaming agent when foaming differs depending on whether it is for adult males, adult females, or children. It may be provided. For example, in accordance with the difference in the average value of the intraoral volume between adult men and adult women revealed based on Table 2, for example, the weight of the foaming agent of the foam cleaning tablet for oral cleaning for adult men is 0.24. The weight of the foaming agent of the effervescent tablet for oral cleaning for adult women may be 0.14 g or more and 0.28 g or less. Further, the weight of the foaming agent of the foamable tablet for oral cleaning for children may be an appropriate numerical value in the range of about 0.04 to 0.3 gram depending on the age.

<Effect>
According to the present embodiment, the foaming agent at the time of foaming has an appropriate volume, i.e., sufficiently spread around the teeth and tongues to obtain the required cleaning effect, but is contained in the mouth as much as possible. It is possible to provide an effervescent tablet for oral cleaning whose weight is adjusted so that the volume is such that it is not understood.

<Overview>
The foamable tablet for oral cleaning of a present Example is a thing whose volume of the base material for tablets is 1/1500 or more and 2/1500 or less of the volume at the time of foaming of a foaming agent.

<Configuration>
The tablet of this example is basically the same as the tablet of Example 1 or 2, but is characterized in that the volume of the tablet base material is 1/1500 or more and 2/1500 or less of the foaming volume of the foaming agent. There is. The base material for tablets is often made of a hard material such as crystalline cellulose, which is related to good taste. At that time, the good mouthfeel is not determined by the absolute amount of the tablet base material, but depends on the relative relationship with the volume of the foaming agent when foamed. At that time, if the volume of the tablet base material is excessive with respect to the foaming volume of the foaming agent, the feeling of firmness is too strong and the mouth feels worse, while the volume of the tablet base material is foamed by the foaming agent. If it is too small relative to the volume of time, the inside of the mouth will be almost only foam and there will be no crunch and the mouthfeel will be worse. That is, the ratio of the volume of the tablet base material to the volume of the foaming agent when foaming is not excessively large or small, and is preferably within an appropriate range. In this regard, the inventor of the present invention has found that if the volume of the tablet base material is 1/1500 or more and 2/1500 or less of the foaming volume of the foaming agent, an appropriate palatability can be obtained. . Then, the tablet of a present Example provides what the volume of the base material for tablets is such a volume. As described above, since the volume of the foaming agent at the time of foaming is 26 ml or more and 53 ml or less, the volume of 1/1500 or more and 2/1500 or less is about 0.018 to 0.071 ml. In the case of a tablet having the structure shown in Table 3 above, for example, if the shape is as shown in FIG. 1 below, the volume is about 0.41 to 0.82 ml. Therefore, in this case, the volume of the tablet base material in this example is about 2 to 17 percent of the total tablet volume.

<Effect>
According to the present embodiment, it is possible to provide an effervescent tablet for oral cleaning that can obtain an appropriate texture when the tablet is included in the mouth.

<Overview>
The effervescent tablet for oral cleaning of the present example has an average particle size of the tablet substrate of 50 microns to 100 microns.

<Configuration>
(Tablet base material: average particle size)
As described in the previous example, if the volume of the tablet substrate is 1/1500 or more and 2/1500 or less of the foaming volume of the foaming agent, moderate mouthfeel can be obtained, but at the same ratio Even if there are a relatively large number of relatively small tablet particle substrates and a relatively small number of relatively large particle tablet substrates. The taste is different. In this case, if the particle size of the tablet base material is excessively large, the feeling of firmness is too strong and the mouthfeel becomes poor, while if the particle size of the tablet base material is excessively small, there is almost no texture and the mouthfeel is still not good. It gets worse. In this regard, the inventor of the present invention has found that when the average particle size of the tablet base material is 50 microns or more and 100 microns or less, an appropriate texture can be obtained.

<Effect>
According to the present embodiment, it is possible to provide an effervescent tablet for oral cleaning that can obtain an appropriate texture when the tablet is included in the mouth.

<Overview>
The effervescent tablet for oral cleaning of a present Example is a thing with an average particle diameter of an abrasive | polishing agent of 10 microns or more and 30 microns or less.

<Configuration>
(Abrasive: Average particle size)
The tablet of this example is basically the same as the tablet of Examples 1 to 4, but is characterized in that the average particle size of the abrasive is 10 to 30 microns. This configuration takes into account that the abrasive is sufficiently distributed around the teeth and the gap according to the foaming of the foaming agent so that a suitable polishing effect can be obtained. That is, since there is a need to make the tablet less noticeable when it is included in the mouth, the preferred size of the tablet of this example is limited to a certain level, and the abrasive contained in the tablet is also constant. There are limits. For example, as shown in Table 1, a suitable mass ratio of silicic anhydride, which is an abrasive, is about 11.7 percent per tablet. Therefore, if the average particle size of the abrasive is excessive, the number of abrasive particles decreases, making it difficult to ensure that the abrasive is sufficiently distributed around the teeth and the gap. If the particle size is too small, a sufficient polishing effect cannot be obtained. In this regard, the inventor of the present invention, when the average particle size of the abrasive is 10 microns or more and 30 microns or less, ensures that the abrasive is sufficiently distributed around the teeth and a sufficient polishing effect is obtained. I found out that Therefore, the tablet of this example provides a product having an average particle size of the abrasive having such a length.

<Effect>
According to the present embodiment, when the tablet is included in the mouth, the foaming tablet for oral cleaning can be provided so that the abrasive is sufficiently distributed around the teeth and the gap between the teeth, and a sufficient polishing effect can be obtained. .

<Overview>
The foamable tablet for oral cleaning according to the present example has a surface roughness of 100 to 300 microns in terms of arithmetic average roughness.

<Configuration>
(Tablet: surface roughness)
The tablet of this example is basically the same as the tablets of Examples 1 to 5, but is characterized in that the surface roughness is not less than 100 microns and not more than 300 microns in terms of arithmetic average roughness. Arithmetic mean roughness is a measure of roughness defined in the JIS B 0601 standard, and only the reference length is extracted from the roughness curve in the direction of the average line, and the deviation from the average line of the extracted part to the measurement curve. It is represented by a value obtained by averaging the sum of absolute values.

  The purpose of the configuration of this example is to make the tablet surface uneven to some extent by setting the value of the arithmetic average roughness of the tablet to a certain level or more, and when contained in the mouth, the water in saliva is immersed in the recess. By facilitating the penetration, the foaming agent is more easily promoted. However, if the value of the arithmetic average roughness is excessive, the concave portion of the tablet becomes relatively deep, and it may take time for moisture to penetrate into the concave portion, which may hinder the promotion of foaming. It is also necessary to make the value of the arithmetic average roughness of less than a certain value. Therefore, in light of empirical rules, in this example, the value of the arithmetic average roughness of the tablet was set to 100 microns or more and 300 microns or less. If it is this range, when a tablet is included in the mouth, saliva appropriately soaks into the concave portion of the tablet, and the foaming agent can be sufficiently foamed in a short time.

  In order to make the foaming agent sufficiently foam in a short time so that the moisture in the saliva can easily penetrate into the concave portion of the tablet, the tablet surface is often not coated with oil or fat, which is often used to prevent drying. It is desirable that the mixture containing the foaming agent is exposed on the surface. However, in that case, it is necessary to prevent the foaming agent from foaming by sucking moisture in the air before use. Therefore, it is preferable that the tablet of the present embodiment is stored and stored in a package capable of keeping the air inside dry. Based on this preserving method, the tablet of this example can be such that the mixture containing the foaming agent is exposed on the surface, and as a result, when the tablet is included in the mouth, saliva is absorbed into the tablet. It is possible to appropriately soak into the recess and to produce an effect of sufficiently foaming the foaming agent in a short time. In addition, about the suitable structure of the packaging tablet which accommodated the foamable tablet for oral cleaning in the package, it mentions later in another Example.

<Effect>
According to this embodiment, when a tablet is put in the mouth, saliva appropriately soaks into the concave portion of the tablet, and an effervescent tablet for oral cleaning capable of sufficiently foaming the foaming agent in a short time is provided. Can do.

<Overview>
The foamable tablet for oral cleaning of the present embodiment has a substantially cylindrical shape having a substantially convex lens shape on the upper and lower surfaces, a height corresponding to the optical axis direction of 5 mm or more and 7 mm or less, and a length corresponding to the lens diameter. It is 12 mm or more and 14 mm or less, and the cylindrical side surface equivalent height is 3 mm or more and 4 mm or less.

<Configuration>
(Tablet: dosage form)
1A and 1B show an example of the shape of a tablet according to the present embodiment. FIG. 1A is a plan view, and FIG. 1B is a sectional view taken along line XX in FIG. As shown in this figure, the dosage form of the tablet 0110 of the present example is a substantially cylindrical shape in which the upper surface 0111 and the lower surface 0112 have a substantially convex lens shape, and the height 0113 corresponding to the optical axis direction is not less than 5 millimeters and not more than 7 millimeters. The lens diameter equivalent length 0114 is not less than 12 millimeters and not more than 14 millimeters, and the cylindrical side face equivalent height 0116 is not less than 3 millimeters and not more than 4 millimeters. The rest of the configuration is the same as that described in the first to sixth embodiments.

  The purpose of the configuration of this example is to make the shape (dosage form) of the tablet suitable for maximizing the surface area, especially the area of the surface that contacts the tongue or palate as much as possible. However, in addition to simply increasing the surface area, the shape is easy to mold and take during manufacture, and care is taken to create a shape that is somewhat thick to provide a surface roughness of a certain level or more. It is what. Taking these various factors into consideration, in this embodiment, the dosage form has a substantially cylindrical shape with upper and lower surfaces having a substantially convex lens shape, the height corresponding to the optical axis direction is not less than 5 mm and not more than 7 mm, and the length corresponding to the lens diameter. It is assumed that the height is 12 mm or more and 14 mm or less, and the height equivalent to the cylindrical side surface is 3 mm or more and 4 mm or less. As a result, the area of the upper and lower surfaces becomes relatively large, and the entire surface area, particularly the area of the surface in contact with the tongue and palate can be increased. Moreover, it can be set as the shape which is easy to take by making the upper and lower surfaces of a tablet into a substantially convex lens shape. In addition, since a certain degree of thickness can be obtained by making the center a substantially cylindrical shape with a substantially convex lens shape, it is easy to have a surface roughness of a certain level or more. If the tablet has such a shape, it can be easily produced and taken, and the foaming agent can be sufficiently foamed in a short time by increasing the surface area.

<Effect>
According to this example, it is possible to provide an effervescent tablet for oral cleaning that can be easily produced and taken, and can sufficiently foam the foaming agent in a short time by increasing the surface area.

<Overview>
The effervescent tablet for oral cleaning of a present Example is a thing of the value whose surface roughness of a substantially cylindrical side surface is lower than the surface roughness of the upper and lower surfaces of a substantially convex lens shape.

<Configuration>
The foam cleaning tablet for oral cleaning of the present embodiment is basically the same as the tablet shown in FIG. 1 in the previous embodiment, but the tablet of the present embodiment has a surface roughness of the substantially cylindrical side surface 0115 having a substantially convex lens. It is characterized in that it has a value lower (smaller) than the surface roughness of the upper and lower surfaces 0111 and 0112 of the shape.

  The purpose of making the surface roughness of the side surface lower than the surface roughness of the upper and lower surfaces of the substantially convex lens shape is as follows. That is, as described above, the surface roughness of the tablet is set to a certain level or more to make the surface of the tablet somewhat uneven, and when contained in the mouth, the water in the saliva soaks into the recess. By making it easier, foaming of the foaming agent can be further promoted. At that time, if the surface roughness of the side surface and the surface roughness of the upper and lower surfaces of the substantially convex lens shape are the same, the water in the saliva soaks into the tablet surface almost evenly. For this reason, foaming occurs almost evenly from the entire surface of the tablet, and the entire tablet shrinks almost evenly accordingly. On the other hand, according to the configuration of the present embodiment, the upper and lower surfaces of the substantially convex lens shape having a relatively high (large) surface roughness value are foamed at a relatively faster pace, and foamed from the side surface. Will be relatively suppressed. For this reason, for example, compared with the case where the surface roughness of the upper and lower surfaces is the same as that of the side surfaces, it is possible to slow the foaming pace and maintain the foaming time.

  In addition, since tablets taken in the oral cavity are usually arranged so that either the upper or lower surface is in contact with the tongue, foaming from the surface in contact with the tongue is further promoted, and especially in the oral cavity, bad breath etc. It is possible to contribute to the removal of tongue coating that tends to cause

  In addition, the whole tablet does not shrink uniformly with foaming, but it shrinks in a form that is flatly crushed from the top and bottom, and the state where the contact surface with the tongue is kept wide is relatively long. It will continue, and it is possible to maintain the good taste that is often felt with the tongue.

<Effect>
According to the present embodiment, the foaming from the upper and lower surfaces of the substantially convex lens shape is relatively promoted and the foaming from the side surface is relatively suppressed, thereby slowing the pace of foaming and maintaining the foaming time, It is possible to promote foaming relative to each other and to maintain good taste.

<Overview>
The present embodiment relates to a packaging tablet comprising a tablet and a container for packaging the tablet, the packaging is a press-through pack, and the crushing scheduled surface in contact with the tablet is made of an uncolored aluminum alloy foil. It is. Also, the packaging tablet of this embodiment includes a press surface made of a transparent plastic material.

<Configuration>
(General)
2A and 2B are diagrams showing an example of the appearance of the packaged tablet according to the present embodiment. FIG. 2A is a plan view, and FIG. 2B is a sectional view taken along line XX of FIG. As shown in the figure, the packaged tablet 0200 of the present embodiment is composed of a tablet 0210 and a container 0220 for packaging the tablet. The tablet is the same as the tablet described in each of the foregoing examples.

(Container for packaging tablets)
A container for packaging tablets (hereinafter referred to as “packaging container”) includes an aluminum alloy foil sheet 0221 and a cover 0222 made of a transparent plastic or the like and disposed on the sheet. The cover has a storage portion 0224 that forms a space for storing tablets. The characteristic of the packaging container in the present embodiment is that the packaging is a press-through pack, and the crushing planned surface 0222 that comes into contact with the tablet is made of an uncolored aluminum alloy foil.

  A press-through pack (also referred to as a “press-through package”) is a package having a structure in which a container made of a transparent resin or the like having a space for containing a tablet is bonded to a sheet made of metal, etc. When the portion (press surface) is pushed toward the sheet side, the tablet accommodated in the interior of the accommodating portion breaks through the sheet and is pushed out of the package so that the tablet can be taken out. Thereby, the inside of an accommodating part can be maintained in the dry state, and it can prevent that a tablet gets wet even if it does not give fat and oil coding etc. to a tablet.

  The planned crushing surface in contact with the tablet is made of uncolored aluminum alloy foil. Here, the planned crushing surface refers to the surface of the sheet that contacts the tablet. FIG. 2 (c) is an enlarged view of a portion surrounded by a broken line circle 0201 in FIG. 2 (b) in order to illustrate this state in an easy-to-understand manner, where the planned crushing surface 0223 is on the side in contact with the tablet 0210 of the sheet. It shows that it says a surface. The range of the planned crushing surface refers to a range d surrounded by the cover on the upper surface of the sheet (in other words, the surface not bonded to the cover on the upper surface of the sheet).

  If a colored paint is applied to the surface to be crushed, the coating applied to the surface to be crushed is scraped to the abrasive if the tablet is not coated with oil or fat and the abrasive is exposed on the surface. For example, it may adhere to or penetrate into the surface of the tablet, and the color may be transferred to the surface of the tablet, or the active ingredients of the tablet may be damaged by the components of the paint. In view of this, the packaging tablet in the present embodiment is such that the planned crushing surface is not colored so that there is no such a fear.

  The press surface is preferably a transparent plastic material. By doing in this way, the external appearance of a tablet can be seen with packaging. Moreover, it can implement | achieve suitably maintaining the state which dried the tablet by making a crushing plan surface into aluminum alloy foil, making a press surface into plastic, and making both closely_contact | adhere and forming a packaging container.

<Effect>
According to this embodiment, it is possible to provide a packaged tablet in which the color does not move to the surface of the tablet or the active ingredient of the tablet is not damaged by the components of the paint.

<Overview>
The packaged tablet of this example is a sheet-like form in which the press-through pack can be separated by a set of 3 tablets.

<Configuration>
The packaged tablet of the present embodiment is characterized in that the press-through pack is a sheet that can be separated by a set of 3 tablets.

  FIG. 3 is a diagram showing an example of the appearance of the packaged tablet according to the present embodiment, which is a plan view. However, illustration of a tablet was abbreviate | omitted and only the packaging container 0320 was shown. As shown in this figure, the packaged tablet of the present embodiment is a sheet shape in which a press-through pack as a package can be separated by a set of 3 tablets. In the example of this figure, three sets of packaging containers 0320a, 0320b, and 0320c that can accommodate three tablets in one set are formed so as to be separable at perforations 0325. The reason why it is configured to be detachable in units of 3 tablets in a set is configured to be convenient for its use in light of the fact that the tablets are often taken three times a day (morning, noon, evening). It is what. For example, when going on a trip or business trip over a plurality of days, it is only necessary to separate and bring the sheets for the number of days, so that the necessary number of tablets can be easily prepared. The rest of the configuration is the same as that of the packaged tablet described in Example 9.

<Effect>
According to the present embodiment, it is possible to easily prepare a necessary number of tablets according to the number of days of travel or business trip.

<Overview>
The packaged tablet of the present embodiment is a sheet form in which the press-through pack can be separated by a set of three tablets, and the press-through pack is provided with a rib for preventing sheet bending deformation.

<Configuration>
FIG. 4 is a diagram showing an example of the appearance of the packaged tablet according to the present embodiment (similar to FIG. 3, illustration of the tablet is omitted and only the package container is shown), which is a plan view. As shown in the figure, the packaging container 0420 of the packaging tablet of the present embodiment is a sheet shape in which the press-through pack can be separated by a set of three tablets, and a rib 0435 for preventing sheet bending deformation is provided on the press-through pack. (To avoid complications, only one set of each of FIGS. 4 (a), (b), and (c) is labeled with a rib). The rib is formed, for example, by providing a convex portion so that a part of a portion arranged in contact with the sheet of the accommodating portion rises to the upper surface side by press working.

  The purpose of providing such ribs is that when the packaged tablet is carried around in a bag or clothes pocket, the sheet is bent and deformed by being pressed, etc., and there is a slight crack in the planned crushing surface. This prevents the tablet from being damaged or moistened. The position of the rib is appropriately designed at a position where bending deformation of the sheet does not occur. In particular, in view of the above-described purpose, it is desirable that the rib be provided at a position including the vicinity of the planned crushing surface. 4 (a) to 4 (c) are all suitable for this point. In addition, the example of this figure is configured so that the sheet can be separated in units of 3 tablets, similar to that shown in FIG. 3 in the previous embodiment, but the tablet placement position is appropriate considering the rib placement. For example, those shown in (a) and (b) are arranged so as to be staggered on the left and right, and those shown in (c) are arranged in a vertical row. It is.

<Effect>
According to the present embodiment, it is possible to prevent the sheet from being bent and deformed and cracking on the planned crushing surface.

Examples of the present invention will be described below. The relationship between the embodiments and the claims is as follows. Example 1 mainly relates to claim 1, claim 3, etc., Example 2 mainly relates to claim 2, claim 3, etc., Example 9 mainly relates to claim 4, etc., Example 10 mainly The eleventh embodiment mainly relates to claim 6 and the like. Examples 3 to 8 relate to inventions related to the present invention. In addition, this invention is not limited to these Examples at all, and can be implemented in various modes without departing from the gist thereof.

Claims (12)

  An effervescent tablet for oral cleaning formed by tableting a mixture comprising a tablet substrate made of a material containing crystalline cellulose, a foaming agent containing sodium bicarbonate, and an abrasive containing silicic anhydride, wherein the foaming agent is An effervescent tablet for oral cleaning having a volume at the time of foaming of 26 ml or more and 53 ml or less.   The foaming agent is one or more of sodium hydrogen carbonate, magnesium hydride, calcium hydride, and sodium aluminum hydride, and the total weight thereof is 0.2 g or more and 0.4 g or less. The effervescent tablet for oral cleaning as described.   The mouth-cleaning effervescent tablet according to claim 1 or 2, wherein the tablet substrate has a volume of 1/1500 or more and 2/1500 of a volume when the foaming agent is foamed.   The oral cleaning foamable tablet according to any one of claims 1 to 3, wherein the tablet base material has an average particle size of 50 microns to 100 microns.   The foaming tablet for oral cleaning according to any one of claims 1 to 4, wherein the abrasive has an average particle size of 10 to 30 microns.   The effervescent tablet for oral cleaning according to any one of claims 1 to 5, wherein the surface roughness is not less than 100 microns and not more than 300 microns in terms of arithmetic average roughness.   The dosage form has a substantially cylindrical shape having a substantially convex lens shape on the upper and lower surfaces, the height corresponding to the optical axis direction is not less than 5 mm and not more than 7 mm, the length corresponding to the lens diameter is not less than 12 mm and not more than 14 mm, and corresponds to the side surface of the cylinder The effervescent tablet for oral cleaning according to any one of claims 1 to 6, wherein the height is 3 mm or more and 4 mm or less.   The foamable tablet for oral cleaning according to claim 7, wherein the surface roughness of the substantially cylindrical side surface is lower than the surface roughness of the upper and lower surfaces of the substantially convex lens shape. A packaging tablet comprising the foamable tablet for oral cleaning according to any one of claims 1 to 8, and a container for packaging the tablet,
The packaging is a press-through pack, and the crushing surface that comes into contact with the tablet is a packaging tablet made of uncolored aluminum alloy foil.   The packaging tablet according to claim 9, wherein the press surface is a transparent plastic material.   The packaged tablet according to claim 9 or 10, wherein the press-through pack has a sheet shape that can be separated by a set of three tablets.   The packaged tablet according to any one of claims 9 to 11, wherein the press-through pack is provided with a rib for preventing sheet bending deformation.

Images