TWI359642B - Oral care implement housing an oral care agent - Google Patents
Oral care implement housing an oral care agent Download PDFInfo
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- TWI359642B TWI359642B TW097102586A TW97102586A TWI359642B TW I359642 B TWI359642 B TW I359642B TW 097102586 A TW097102586 A TW 097102586A TW 97102586 A TW97102586 A TW 97102586A TW I359642 B TWI359642 B TW I359642B
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- A—HUMAN NECESSITIES
- A46—BRUSHWARE
- A46B—BRUSHES
- A46B11/00—Brushes with reservoir or other means for applying substances, e.g. paints, pastes, water
- A46B11/001—Brushes with reservoir or other means for applying substances, e.g. paints, pastes, water with integral reservoirs
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- A—HUMAN NECESSITIES
- A46—BRUSHWARE
- A46B—BRUSHES
- A46B11/00—Brushes with reservoir or other means for applying substances, e.g. paints, pastes, water
- A46B11/001—Brushes with reservoir or other means for applying substances, e.g. paints, pastes, water with integral reservoirs
- A46B11/0068—Brushes where the reservoir is specifically intended for solid substance that dissolves gradually
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A—HUMAN NECESSITIES
- A46—BRUSHWARE
- A46B—BRUSHES
- A46B2200/00—Brushes characterized by their functions, uses or applications
- A46B2200/10—For human or animal care
- A46B2200/1066—Toothbrush for cleaning the teeth or dentures
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- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
- Brushes (AREA)
Description
U59642 i 九、發明說明: 【發明所屬之技術領域】 本發明關於具有可於使用者口内傳送以提供增進的 口腔健康之藥劑之口腔保健用具。 5 ’、 【先前技術】 人類顯不出許多不良的口腔健康形式,包含蛀牙、 牙周疾病及不良呼吸(口臭)。虹牙及牙周疾病通常係由口 内有,菌造成。當有#菌與唾液中之蛋白質混合時,牙 10斑的薄膜形成在牙齒和軟質組織上。倘若未移除牙斑, 則其可能侵蝕牙齒並且產生蛀洞。另外,牙斑可能侵蝕 口内的軟質組織,並且產生牙齦疾病(其為成人缺牙的主 要原因)。因此,減少口中有害菌含量已長斯間成為從事 口腔健康保健領域之人士的目標。 15 使口内有害菌減至最少之最常見的方法為以傳送至 • 少一種口腔保健劑於口中之牙膏刷洗。口部引入的液體 (包含含漱劑)亦用以提供除刷洗外之額外的口腔保健。漱 口水亦可用於傳送口内之呼吸清新劑,進而消除不良呼 吸。 20 遺憾地’個人並非總是有時間於適當口腔保健。舉 例來說’忙碌的人可能沒有時間或耐性於徹底刷洗、用 牙線潔牙及/或使用含漱劑《另外,某些人可能認為刷牙 根本是不必要的。基於此等理由,於完成口腔保健例行 工作之後,這些人可能於其口中留下極大量的有害菌, 5 1359642 此可能開始侵蝕其牙齒和牙齦。U59642 i IX. Description of the Invention: [Technical Field] The present invention relates to an oral health care appliance having a medicament that can be delivered in a mouth of a user to provide improved oral health. 5 ‘, [Prior Art] Humans do not show many bad oral health forms, including tooth decay, periodontal disease and bad breath (bad breath). Rainbow teeth and periodontal disease are usually caused by bacteria in the mouth. When #菌 is mixed with protein in saliva, a 10-spotted film is formed on the teeth and soft tissues. If the plaque is not removed, it may erode the teeth and create a cavity. In addition, plaque may erode the soft tissue in the mouth and cause gum disease (the main cause of missing teeth in adults). Therefore, reducing the amount of harmful bacteria in the mouth has become the goal of people in the field of oral health care. 15 The most common method of minimizing harmful bacteria in the mouth is to wash the toothpaste in the mouth with less than one oral health supplement. The liquid introduced into the mouth (including the gargle) is also used to provide additional oral care in addition to brushing. Mouthwash can also be used to deliver breath fresheners in the mouth to eliminate bad breath. 20 Regrettally, individuals do not always have time for proper oral care. For example, a busy person may not have the time or patience to thoroughly brush, floss, and/or use an expectorant. In addition, some people may think that brushing is not necessary at all. For these reasons, after completing routine oral health care, these people may leave a very large number of harmful bacteria in their mouths, 5 1359642 which may begin to erode their teeth and gums.
因此,有必要提供一 俾改良口腔健康。 種於刷洗過程中傳送藥劑之牙 【發明内容】 發明概述 10 15Therefore, it is necessary to provide an improved oral health. A tooth for delivering a medicament during a brushing process [Summary of the Invention] Summary of the Invention 10 15
20 2明關於具有可於使❹口㈣送錢供增進的 口腔健康之藥劑之口腔保健用具。 本發明之-態樣係關於—種透過孔洞或多孔性薄膜 而傳送口腔保健劑於使用者口腔之口腔保健用呈。、 根據一態樣,口腔保健用具包含具有至少一部分經 形成以定義-或多個凹槽之頭部。至少一種口腔保健劑 係提供於-或多個凹槽中’並且當口腔保健劑接觸口腔 内的流體或化學物質時分配於使用者口中。 根據一態樣,口腔保健用具包含位於頭部的一或多 個凹槽内之口腔保健活㈣卜可透過韻頭板(_ U plate)分配藥劑。 根據一態樣,口腔保健用具包含位於頭部的一或多 個凹槽内之π腔保健活性劑。可透過位於相反於竊賊頭 板之薄膜分配藥劑。 根據一態樣,口腔保健用具包含位於頭部的一或多 個凹槽内之口腔保健活性劑。可透過具有至少一孔洞之 簇絨頭板和位於相反於簇絨頭板之薄膜分配藥劑。 根據一態樣,口腔保健用具是可重新使用或用完即 6 1359642 =個使用過程中、於多次使用過程中或於用具 的氙個可用的壽命中,可釋放口腔保健活性劑。口中之 水、分泌物及/或化學物質可活化口腔保健劑。 5 【實施方式】 欲引口腔保健用具^其具有狹長把手和 構,以ir二 刷’但可具有任-形狀或結 !。:能種容許其傳送口腔保健劑於使用者之 nn保健用具的非限定實例包含舌部清 用具可單次使用且接著搬棄之,或者 腔;r手10可由多種形狀形二=多 15 腔保健用具1容易握持和於使用者。中操縱之 頭部20包含複數個於使用 表面。於圖i_3所示之具體例中$ :暴路於口中流體之 22及相對的第- # & 碩邛20包含第一表面 ㈣的第一表面24〇側壁26 20 之間。口腔保健元件3〇可從頭部2〇的:=22、24 24延伸,其中元件3〇可包含潔 或一表面22、 彈性體指狀物,或軟質組織清潔:件35 ’例如刷毛或 22、24延伸之舌部清潔構件(未顯示卜 從任一表面 此中所述之口腔保健元件 腔保健元件包含可為任—種述者。口 4通用於藉由與部分牙 7 =或^酿接觸而提供口腔健康 匕牙窗潔白、按摩、刺激等)之結(構之;::牙齒拋 件”。此等潔牙元件包含(但不限於)可成二牛”或” 許多不同形狀和尺寸 成形為具有 …同形狀和尺寸: = 絨以及可成形為具有許 彈性體清潔元件二者之組合Μ几件、或刷毛的簇絨與 如圖4Α、4Β及s ήί - 包含底座40及蔡織插件斤61,/腔保健用具1的頭部20 如圖从所亍Ϊ! 0 ’例如蔟絨頭板。當組裳時, ίο 或多個凹槽%。件6G係設於❹40上’以形成- 映義上’ 口腔保健用具1提供用於儲存至少一錄 性劑之頭部2〇,俾引入口部以進行所需功二 、二例中’ 口腔保健劑可提供於頭部2 : 一或多個凹槽50中。凹槽 〒所I成之 15 多種可分配的口腔保㈣ •接收、保留及容納一或 半液體形式之此等可接收或容納液體或 式,例如一種慢溶專^1片列=構性凝膠;以及固體形 或兩種諸如分散二4片二種硬糖,,形式、壓縮粉末; 栌亦m : 發泡體中之液體的混合物。凹 20 ]播夕種格式之複數口腔保健活性劑。於一具體 定量或填滿凹槽為止。二:保健劑’直到已接收預 二 狀:俾確保最佳傳送有益的各種口 少種於二用°以下將更詳細說明者,凹槽50可儲存-或 腔保健用具1過程中欲分配的口㈣㈣。 8 1359642 '' 請繼續參照圖4A、4B及5,底座40包含殻體41及 / 薄骐45»殼體41可經成形以促進使用於口腔保健用具 中》為了說明之目的,可將底座40描述為具有殼體& 的外壁、垂直壁42、44、46以及水平壁、53。視具有 5狹長把手1〇及/或殼體41之口腔保健用具的形狀 和材料規格而定’垂直壁42、44、46及水平壁43&5°3 可以不同架構排列。同樣地,底座40可具有較大戋較+ •數目的壁42、43、44、46及53’因為此等壁的性質非‘ 定及啟發性說明輔助頭部組裝和安定性之例示結構。頭 10部20的底座40可於與把手10同時成形為單一元件。 外,頭部20可製為經組裝為口腔保健用具i的部件之 件。可經由若干技術,包含經超音波、雷射焊接,或經 由亦容許移除和拋棄頭部20之機械技術,來貼附接 頭部20元件。 妖 15 20 如圖4A和5所示 溥膜45具有凹槽側48及外 的。於此等例圖中,凹槽側48係為薄膜45緊鄰凹槽乂 之-側。、可使用不同的材料和結構性構造。舉例來^, 於織造或模塑構造中,可使用十a J使用耐綸、塑料或不同的細绰 (^_)材料。薄膜可由細絲成形,it常係以許多圖案 中之任-者建構或裝#。再者,薄膜Μ 多、 個孔或刺孔於其中之大體卜革如从 ^ 4夕 一 τ <八锻上千坦的塑膠構件, 質流經塑膠構件。薄膜45之容;& ° 栝杜所經多孔性可被調整以控制活性 插件所釋放之材料量流動◊如 —^ , a 121 4A所不,一或多種物皙 可於一或夕個方向流經薄骐 、 听舉例來說,物質可從凹 9 1359642 槽側48流向外侧49,並且進入使用者口部以施加口腔保 健劑。另外,薄膜45可經建構,使得諸如水或唾液或其 他活性劑流體等物質於相反方向(從外側49至凹槽側Μ、 Λ丨L動例、示的〃丨L體箭號! 45代表如所述的例示流體路徑。 10 15 20 雖然薄膜45可位於底座4〇表面的幾乎中央區,二但 其可設於頭部或其一部分的不同部件中。殼體4ι圍适簿 m緣’並且可提供對於薄狀支持及_“ ^ S 口中使用期間)。可藉由包含熔化、黏合、卡扣士 J似方式將薄膜45永久地或暫時地固定 ^ :形:多其他構造是可預期的,因為薄膜可成形為使: 口腔保健用具的頭部2〇的第二表面“的以 口P。於此一情況下,可藉由許 :王 於其第-側48或第二側49固定於 :膜 於其邊緣處固定於殼體41之外 ^ 了或替代 薄膜-連同把手1〇和頭部2。)_:塑:依早-形式將 46及於二t、4B及5之例示結構中,壁42、43、44、 及53係經建構以形成分別用於 件55和簇絨插件6〇的底座6 、圍薄膜45、(活性插 故其可永久地或暫時地固定在—之:一:之壁架和側壁, 卡固特徵118(例如溝槽或突出構,。需,時’亦可使用 61卡固於頭部20的底座4〇。卡以引及/或將底座 ,併黏著性物質之物理性機構。可包含單獨 卡固特徵。 了使用不同的構造於 睛參照圖4Α、4Β、5、6Α 6Β ’此中例示之簇絨 10 I3>9642 插件60包含底庙以 件30。可含有潔牙^35之口腔保健元 性固定(包含錯定^法,包含黏合、模塑、溶化及機械 30 *成簇(AFT)技術),將口腔保健元件 弋:碩邛20。在此,口腔保健元件3〇 =插:二的底座61。底座61亦可含有具有一或= 之導管65,俾容許不同物質(包含口腔保健 f),又向>地流於凹槽5〇與底座61的外側63之間。舉例來 插侔L谷:Γ括於凹槽50中之口腔保健劑傳送通過簇絨 —座61至外側63上的口腔保健元件30。同樣 ’可容許流體從外側63以逆向流經底座61至凹槽$ :流體的例示實例可為水或來自使用者口部之唾液, ^用做儲存於凹槽5G中之活性材料55用之觸媒或活 15 體性質(包含流率、粒度、尺寸、溶解度等)而定, 了:可包含不同的物理性結構、截面形狀及材料。為 =之目的’導管65可包含具有圓形、多邊形和不規 之孔洞或管件,及/或亦可與網眼、筛孔或過遽型 Ϊ職ί^。流體箭號64代表不同物f於兩方向流動 65’並且更通常地經過蔡賊插件6〇的底座61。 :::造可調節、阻礙、限制或抑制流動,使得流體係 規。1《專有地於與所述者一致的方向以改變程度出 揭sn牛例來說’通過底座61之流體可僅從外侧63至凹 相反方向(凹槽5〇至外侧63),或於兩方向 (例如受到薄膜45或導管65控制)。 20 1359642 ' 喃酮、細菌素、黃烷、類黃酮、葉酸、維生素、礦物質、 過氧化氫、過氧化脲、過碳酸鈉、pvp-h2o2、聚合物結 合的過氧化物、硝酸卸、咬合劑、生物活性劑、精胺酸 鹽類、精胺酸碳酸氫鹽、巴茶林(bachalin)、多紛類、丙 5 酮酸乙酯、胍基乙基二硫、牙垢控制劑、防污成分、礙 酸鹽、聚乙烯基膦酸、P VM/MA共聚物、酵素、葡萄糖 氧化酶、木瓜蛋白酶、無花果蛋白酶 '月桂醒精胺酸乙 Φ 酯、薄荷腦、香芹酮、茴香腦、許多調味路類、酯類及 醇類、綠薄荷油、薄荷油、冬青油、黃樟油、丁香油、 10鼠尾草油、桉樹油、墨角蘭油、肉桂油、檸檬油、酸橙 油、葡萄柚油及/或柳橙油。 15 20 可選擇活性劑及/或其媒介以補充牙膏配方,例如藉 由調和調味料、著色劑、美容成分或活性成分。可施^ 調味料’以於刷洗期間產生逐漸的風味變化(這對於單獨 使用牙膏而言目前是不可能的)。此中所述之風味變化以 及其他感覺變化可用作代表有效刷洗例行工作完成之俨 號。於一實施例中,可釋放調味料以顯示口腔保健用且^ 係適當地起作用,或顯示賴i耗盡並準備丟棄或重填。 :添加著色劑以於使用期間產生顏色變、 ;未料及/或顏料以顯示另-利益,例如牙齒潔白或抗3 ,或可能的不安定的及/或可盥 活性劑亦以料促進整體刷 活性劑可與牙膏相容 典型牙膏成分蓋生反應。 洗功效之潔牙劑。 13 135964220 2The oral health care appliance which has a medicine which can be used for the oral health of the mouth (4). The aspect of the present invention relates to oral care for delivering oral health care agents to the oral cavity of a user through a hole or a porous film. According to one aspect, the oral care implement comprises a head having at least a portion formed to define - or a plurality of grooves. At least one oral health care agent is provided in - or a plurality of grooves' and is dispensed into the mouth of the user when the oral care agent contacts fluid or chemicals within the oral cavity. According to one aspect, the oral care implement comprises an oral care activity (4) located in one or more recesses of the head. The medicament can be dispensed through the y U plate. According to one aspect, the oral care implement comprises a π-cavity health active agent located in one or more recesses in the head. The medicament can be dispensed through a film located opposite the thief's head. According to one aspect, the oral care implement comprises an oral health care active agent located in one or more recesses in the head. The medicament can be dispensed through a tufting head having at least one hole and a film located opposite the tufting head. According to one aspect, the oral care implement can be re-used or used up. 6 1359642 = The oral health care active can be released during use, during multiple uses, or within a useful life of the appliance. Water, secretions and/or chemicals in the mouth activate the oral care agent. [Embodiment] To introduce an oral health care appliance, which has a narrow handle and a structure, and has an ir-brush, but may have any shape or knot. A non-limiting example of a health care device that allows it to deliver an oral health care agent to a user includes a tongue cleaning device that can be used in a single use and then discarded, or a cavity; the r hand 10 can be shaped into a plurality of shapes and two more than 15 lumens. The health care appliance 1 is easy to hold and the user. The head 20 is manipulated to include a plurality of surfaces for use. In the specific example shown in Fig. i_3, $: the path of the fluid in the mouth 22 and the opposite -# & 20 include the first surface 24 of the first surface (four) between the side walls 2620. The oral care element 3〇 can extend from the head 2〇:=22, 24 24, wherein the element 3〇 can comprise a clean or a surface 22, an elastomeric finger, or a soft tissue cleaning: a piece 35' such as a bristles or 22, 24 extended tongue cleaning member (not shown from any surface, the oral health care element cavity health care element described herein may be used as any one. The mouth 4 is used for contact with a portion of the tooth 7 = or ^ And provide the knot of oral health, whitening, massage, stimulation, etc. (construction;:: tooth throwing.) These dental elements contain (but are not limited to) two or more "or different shapes and sizes" Formed to have the same shape and size: = velvet and can be formed into a combination of two elastomeric cleaning elements, or a tuft of bristles and as shown in Figures 4Α, 4Β and s ήί - including base 40 and Cai weaving The plug of the plug 61, / the head of the health care appliance 1 is as shown in the picture! 0 'For example, the pile head. When the group is on the skirt, ίο or a plurality of grooves %. The 6G is set on the ❹40' Forming - the upper part of the 'oral health care appliance 1 provides a head for storing at least one recording agent 2 , 俾 introduces the mouth to perform the required work. In the second case, the oral health care agent can be provided in the head 2: one or more grooves 50. The groove can be divided into 15 kinds of dispensable oral protection (4) • receiving, retaining and containing one or more liquid forms of such receivable or containing liquid or formula, such as a slow-dissolving monolithic column = a conformable gel; and a solid form or two such as two or two Hard candy, form, compressed powder; 栌 also m: a mixture of liquids in the foam. Concave 20] a plurality of oral health care actives in a format of sputum, in a specific amount or fill the groove. The agent 'until has received the pre-dimensions: 俾 ensures that the optimal delivery is beneficial. The various types of mouth are less than two. As will be explained in more detail below, the groove 50 can store - or the mouth (4) (four) to be dispensed during the process of the health care appliance 1. 8 1359642 '' With continued reference to FIGS. 4A, 4B and 5, the base 40 includes a housing 41 and/or a thin housing 45. The housing 41 can be shaped to facilitate use in an oral care implement. For illustrative purposes, the base 40 can be used. Described as an outer wall having a housing &, vertical walls 42, 44, 46, and The flat wall, 53. Depending on the shape and material specifications of the oral care implement having 5 elongated handles 1 and/or housing 41, 'vertical walls 42, 44, 46 and horizontal walls 43 & 5° 3 may be arranged in different configurations. Similarly, the base 40 can have a larger number of walls than the number of walls 42, 43, 44, 46, and 53' because the nature of such walls is non-deterministic and instructive to illustrate an exemplary structure for assisting head assembly and stability. The base 40 of the head 10 20 can be formed as a single component at the same time as the handle 10. In addition, the head 20 can be fabricated as a component that is assembled into the oral care appliance i. It can be via a number of techniques, including ultrasound, laser The joint portion 20 is attached by welding, or via mechanical techniques that also permit removal and disposal of the head 20. Demon 15 20 As shown in Figures 4A and 5, the diaphragm 45 has a groove side 48 and an outer portion. In these illustrations, the groove side 48 is the side of the film 45 adjacent the groove 乂. Different materials and structural configurations can be used. For example, in a woven or molded construction, a nylon, a plastic or a different fine ^ (^_) material can be used. The film can be formed from filaments, which are often constructed or loaded in any of a number of patterns. Furthermore, the film has a large number of holes, holes or punctures in which the general body is like a plastic member from the square to the top, and the material flows through the plastic member. The porosity of the film 45; & ° The porosity of the sputum can be adjusted to control the amount of material released by the active insert, such as -^, a 121 4A, one or more objects can be in one or the other direction Flowing through the sputum, for example, the substance can flow from the groove side 48 to the outer side 49 of the recess 9 1359642 and into the mouth of the user to apply the oral care agent. In addition, the film 45 can be constructed such that substances such as water or saliva or other active agent fluids are in opposite directions (from the outer side 49 to the side of the groove, the 动L example, the 〃丨L body arrow! 45 represents An exemplary fluid path as described. 10 15 20 Although the film 45 can be located in an almost central region of the surface of the base 4, it can be placed in different parts of the head or a portion thereof. And can provide for thin support and _" ^ S mouth use period. The film 45 can be permanently or temporarily fixed by including melting, bonding, snap-like manner ^: shape: many other configurations are expected Because the film can be shaped such that: the second surface of the head of the oral health care device "is at the mouth P. In this case, it can be fixed by the king on its first side 48 or the second side 49: the film is fixed at the edge thereof at the outer side of the housing 41 or instead of the film - together with the handle 1 and the head Department 2. )_: plastic: in the early-form form 46 and in the exemplary structures of two, four, four, and five, the walls 42, 43, 44, and 53 are constructed to form the member 55 and the tuft insert 6 分别, respectively. The base 6, the surrounding film 45, (active insertion can be permanently or temporarily fixed to: a: the ledge and the side wall, the fastening feature 118 (for example, a groove or a protruding structure, when needed, when) Use 61 to fix the base 4 of the head 20. The card is used to guide and/or place the base, and the physical mechanism of the adhesive substance. It can include separate fastening features. Use different structures for the eye. See Figure 4Α, 4Β 5,6Α 6Β 'The tufted 10 I3>9642 insert 60 exemplified herein comprises a bottom temple member 30. The oral health care element can be contained in the dental appliance 35 (including the wrong method, including bonding, molding, Melting and mechanical 30 * clustering (AFT) technology, the oral health care component 弋: 邛 20. Here, the oral health care element 3 〇 = plug: two base 61. The base 61 may also contain a catheter with one or = 65, 俾 allows different substances (including oral health care f), and then flows between the groove 5 〇 and the outer side 63 of the base 61. For example侔L Valley: The oral care agent enclosed in the recess 50 is transported through the tufting-seat 61 to the oral care element 30 on the lateral side 63. Also 'allows fluid to flow from the outer side 63 in the opposite direction through the base 61 to the recess $ An illustrative example of a fluid may be water or saliva from the mouth of a user, ^ used as a catalyst or a living substance for the active material 55 stored in the recess 5G (including flow rate, particle size, size, solubility, etc.) Depending on: different physical structures, cross-sectional shapes and materials may be included. For the purpose of =, the conduit 65 may comprise holes, tubes and tubes having round, polygonal and irregular shapes, and/or may also be meshed, screened Hole or over-type ί^. Fluid arrow 64 represents a different object f flowing 65' in both directions and more generally through the base 61 of the thief insert 6 ::. ::: making adjustment, obstruction, restriction or suppression Flow, such that the flow system rules. 1 "Privately in a direction consistent with the person to reveal the degree of change. For example, the fluid passing through the base 61 can only be from the outer side 63 to the opposite direction of the recess (groove 5 〇 To the outside 63), or in both directions (for example, controlled by film 45 or conduit 65) 20 1359642 ' Ketone, bacteriocin, flavan, flavonoids, folic acid, vitamins, minerals, hydrogen peroxide, urea peroxide, sodium percarbonate, pvp-h2o2, polymer-bound peroxide, nitric acid unloading , occlusion agent, bioactive agent, arginine, arginine bicarbonate, bachalin, sulphate, ethyl acetophenate, thiol ethyl disulfide, tartar control agent, Antifouling component, acid salt, polyvinylphosphonic acid, P VM/MA copolymer, enzyme, glucose oxidase, papain, ficinase, laurel, menthol, menthol, carminone, fennel Brain, many seasonings, esters and alcohols, spearmint oil, peppermint oil, wintergreen oil, sassafras oil, clove oil, 10 sage oil, eucalyptus oil, marjoram oil, cinnamon oil, lemon oil, Lime oil, grapefruit oil and/or orange oil. 15 20 The active agent and/or its vehicle may be selected to complement the toothpaste formulation, for example by blending seasonings, colorants, cosmetic ingredients or active ingredients. The seasoning can be applied to produce a gradual change in flavor during brushing (this is currently not possible with toothpaste alone). The change in flavor and other sensory changes described herein can be used as a symbol for the completion of an effective brushing routine. In one embodiment, the flavoring may be released to indicate oral hygiene and function properly, or to indicate that it is depleted and ready to be discarded or refilled. Adding a coloring agent to produce a color change during use; unanticipated and/or pigments to show other benefits, such as whitening or anti-3 teeth, or possible unstable and/or sputum active agents to promote overall brushing The active agent is compatible with the toothpaste and is typically reacted with a toothpaste component. Washing effect of dentifrice. 13 1359642
活性劑可提供於任一種適合的賦形劑中,例如為水 , 溶液或呈凝膠或糊漿形式》賦形劑可具有多種不同的目 視美觀,包含透明溶液或凝膠或不透明溶液或凝膠。賦 形劑的非限定實例包含水、一元醇(例如乙醇)、聚(氧化 5乙烯)(例如聚乙二醇,例如售自Union Carbide之PEG 2M、5M、7M、14M、23M、45M 及 90M)、綾基亞曱基 聚合物(例如售自B.F. Goodrich之Carb〇P〇l⑧93:及97^) • 以及其組合。視諸如活性劑性質及介質所需的性質(例如 黏度)等因素而定,適合的賦形劑之選擇係為熟習本技藝 1〇之人士可明白。牙齒潔白組成物係揭示於美國專利^ 6,770’266及6,669,930號,所揭示者係合併於本案以供 參考。 八 表I顯示一種欲從凹槽分配作為刷洗過程中之 劑之氣化十六基吡錠凝膠。 几圉 15The active agent can be provided in any suitable excipient, such as water, solution or in the form of a gel or paste. The excipient can have a variety of different visual aesthetics, including a clear solution or gel or an opaque solution or coagulation. gum. Non-limiting examples of excipients include water, monohydric alcohols (e.g., ethanol), poly(5 ethylene oxide) (e.g., polyethylene glycol, such as PEG 2M, 5M, 7M, 14M, 23M, 45M, and 90M from Union Carbide). ), mercapto fluorene based polymers (for example, Carb〇P〇l 893: and 97^ from BF Goodrich) • and combinations thereof. Depending on factors such as the nature of the active agent and the desired properties of the medium (e.g., viscosity), the selection of suitable excipients will be apparent to those skilled in the art. The whitening composition of the teeth is disclosed in U.S. Patent Nos. 6,770, 266 and 6,669, 930, the disclosures of each of which are incorporated herein by reference. Eight Table I shows a gasified hexadecano-pyrrolidine gel to be dispensed from the grooves as an agent in the brushing process. How many 15
表I 成分 --------1 _—重量% —--- 2-5 ------- 1〇 Carbopol 974P -----------— PEG 600 FD&C blue#l (於水中之1%溶液) —. 0.5 氯化十六基吡錠凝膠 (Cetylpyridinium chloride) -~~~~~~--— 20 水 — 0.S ~—~~~____ 1359642 凹槽分配之呼吸保 表π實施例顯示欲從此中所述之 護固體緩溶性薄片的組成。Table I Ingredients --------1 _-% by weight —--- 2-5 ------- 1〇Carbopol 974P -----------—PEG 600 FD& C blue#l (1% solution in water) —. 0.5 Cetylpyridinium chloride -~~~~~~--- 20 Water — 0.S ~~~~~____ 1359642 Respiratory Protection Table for Groove Dispensing The π embodiment shows the composition of the solid slow-dissolving sheet to be described herein.
5 表II5 Table II
成分 ________ 羥乙基纖維素 ~~ ~~~i.*% ~—-~~~~_ -----30 羥丙基甲基纖維素 丙二醇 二氯生(triclosarO 0〇 葡萄糖酸鋅 —------乙 U m 3¾ 1¾•仲不 須拆卸頭部20 ::以2二可經建構’ 10 來說,-開口可更得=件,。舉例 被移除’並且將新的活性插件不=以 於凹槽中,僅增加且不二先是= :於口腔保健用具設計中。根據凹槽50:=:可整 縫可位於頭部的末端。狹缝 ^二,狹 = =於另-結構中,口 55時,則可使得一旦完全用完活性插件 15 15 比 9642 有不同形狀和截面之構件。隔柘 相同的純w . 板可*與剩餘底座4〇 /:’成’或其可由不同的材料形成。再者,隔 戈虚Α β $成為底座4〇的永久特徵,例如於單-模塑物 或成為可拆卸或可移動元件。 棋虽物 5 15 位二Γ7和8所示之隔板141係將凹槽50分開為縱向 ^頭。P 20令之兩個次凹槽5〇A和5〇b。於一構造中, 二,板141可包含複數薄膜,藉卩進一步分隔凹槽⑼ :禝數個次凹槽。目前所示之隔板141具有容許物質從 人凹彳θ 50A和50B通過之通道(或反之亦然)之水平導管 、65。然而,視應用而定,此隔板可為固體構件或不具有 ,接次凹槽50Α和50Β之導管之構件。舉例來說,兩個 人凹槽可完全地分開。如是,可使用不具有導管165之 構件,例如固體構件。圖8顯示包為如所述之複數活性 插件55之凹槽50。 圖9和1〇顯示口腔保健用具構造之其他實施例。於Ingredients ________ Hydroxyethyl Cellulose ~~ ~~~i.*% ~--~~~~_ -----30 Hydroxypropyl Methyl Cellulose Propylene Glycol Diclofen (triclosarO 0〇Zinc Gluconate - ------ B U m 33⁄4 13⁄4• Zhong does not need to dismantle the head 20 :: 2 can be constructed '10, - the opening can be more = piece, the example is removed 'and will be new The active insert is not = in the groove, only increase and not first = = in the oral health care appliance design. According to the groove 50: =: the seam can be located at the end of the head. Slit ^ 2, narrow = = In the other structure, when the port 55 is used, the active insert 15 15 has a different shape and cross section than the 9642. The same pure w. the plate can be * with the remaining base 4 /: ' 'Or it can be formed from different materials. Furthermore, the Α Α Α β $ becomes a permanent feature of the base 4 ,, for example in a single-molded or as a detachable or movable element. Chess 5 5 15 Γ 7 The partition 141 shown in Fig. 8 separates the recess 50 into a longitudinal direction. P 20 has two secondary grooves 5A and 5B. In one configuration, the second plate 141 may comprise a plurality of films. Borrow One-step separation groove (9): a number of secondary grooves. The partition 141 currently shown has a horizontal conduit 65 that allows passage of material from the human recesses θ 50A and 50B (or vice versa). However, depending on the application As such, the baffle may be a solid member or a member that does not have a conduit for the secondary grooves 50 and 50. For example, the two recesses may be completely separated. If so, a member without the conduit 165 may be used. For example, a solid member. Figure 8 shows a recess 50 encased in a plurality of active inserts 55 as described. Figures 9 and 1B show other embodiments of the oral health implement construction.
此構造中’隔板141包含將凹槽150分為兩個次凹槽50C 和50D之水平板片構件。在此,次凹槽係垂直地排列, 相較於圖8之例示具體例之次凹槽50Α和50Β則縱向對 齊。 圖11和12顯示另外的口腔保健用具構造。於此構 造中’簇絨插件460進一步包含連接於隔板141或為形 成為簇絨插件的底座61之一部分。如是,當建構頭部時, 四槽可分開為複數如上述相對於圖7和8之架構之次凹 糟。此構造提供可重複使用或可重新填充的類型,其中 17 複數活性插件55係保留於口腔 改變頭部凹槽β & ^、A ’、 〇的頭部,而不須 方法,使得ί蔡㈣健用具1之另-製造 5 用具可為具有開放凹槽之構迕,而旻數口腔保健 多種材料可用以形二曰額外的製造成本。 的市售聚合物中之任一種。於一構”且可包含廣泛類型 係由聚丙稀形成,使得 口腔^用具! 徵(包含尺十格提供具有不同有利特 寸形狀及間隔)之口腔保健g 口腔保健用具i可且有m二健用具舉例來說, 用去口由* Z、 不同迷率傳送口腔保健劑於使 凹槽50。可藉由例如個別凹槽 2大小以及頭部的外表面22、24、26 =二Γ°的形狀,凹槽50之深度及/或所含口:: 健剤的性質,來控制此等速率。 ’、 15 槽50可具有不同尺寸,俾適應不同含量的 伴此’口腔保健用具1可具有不同的口腔 =活性劑釋放性質,以便棚何時及多少每—藥劑傳 你田°腔°凹槽内之材料的本性亦可對於釋放速率且有 2。具有二(或多個)凹槽之優點為來自不同凹槽之不同 约釋放速率將提供新顆的治療策略或感官印象。舉例來 5倘若凹槽5〇Α中之口腔保健劑比在凹槽50Β中更快 ^ ’則可獲致正順序效果。倘若凹槽5〇Α含有牙菌斑 =劑並且則曹50Β含有抗菌劑,則這對於控制總細菌 感木而言可能是相當有利的。或者,倘若凹槽5〇Α和5〇Β 20 1359642 3有不同的绸味劑或濃縮的感覺成分,則其 提供改變的風味於使用者。此風味變化可使刷洗 愉悦,或其可顯示使用者已刷洗夠長時間。 5 10 15 在一構造中,一旦凹槽5〇接收所需的藥劑, 利地使用頭部2〇分配或釋放口腔保健活性劑於口内。冬 f二:之流體及/或化學物質接觸時,可從其個別的凹; 中:並Γ劑二在—構造中,藥劑可浸泡於活性插件材料 ^可當刷牙時釋放於口中。於刷牙過程中,水和 =::::部20中之凹槽5。内的藥劑接觸。這: 珉'、中次泡的口腔保健活性劑從頭部20内的凹_ 5〇 = 使用不同的口腔保健活性劑於相同頭“ 、曰 中,具有提供增效效益於使用者以及兩於治療 口腔疾病之不同治療方法之能力。 ’、 储用所述,可使用廣泛範圍的模塑技術製造口腔保 夂再者,可使用廣泛範圍的材料規格和參數以提 供具f夕種所需性質之口腔保健用具。舉例來說,於至 =例^施例中,口腔保㈣具丨可為了永久使用而 用完口腔健劑之後丟棄 的凹槽料料械造_填充口腔保 5解_本發明參照其特殊具體例闡釋,但以上 “。太:知例僅為說明之用’而非用於限制本發明之範 4~虚,目」之其他態I、優點和變化,$悉本技藝之人 •汗發明時當可明白,並且此等態樣和變化係在本 20 發明之範圍内 内。 ,並且在本發明之說明和申請專利範圍之 【圖式簡單說明】 圖1為一口腔保健用具結構的透視圖; 圖2為圖1之口腔保健用具之一表面的示意圖; 圖3顯示圖丨之口腔保健用具相, 示意圖; 之表面的 圓為圖 股保健用具的側視_ , Ξ Γ為為二1之口腔保健用具的頭部之部分放大圖; 圖5為圖i之口腔保健用具的分解組件圖; 選擇、為類㈣5中所示之插件之㈣插件的 圖7 ^ D腔保健用具的選擇頭部結構的透視圖; 圖8為含有活性口腔保健劑之圖’ 的選擇頭部結構的透視圖; 保健用具 ^ 9為D腔保健用具的選擇頭部結構的透視圖; 圖0為含有活性口腔保健劑 的選擇頭部結構的透視圖; …L保健用具 圖;=為口腔保健用具㈣絨頭板的選擇結構的透視 圖12為圖1 1之 口腔保健用具的簇絨頭板的側視圖。 1359642 5In this configuration, the partition 141 includes a horizontal plate member that divides the groove 150 into two secondary grooves 50C and 50D. Here, the sub-grooves are vertically aligned, and are longitudinally aligned with respect to the sub-grooves 50 Α and 50 具体 of the specific example of Fig. 8 . Figures 11 and 12 show additional oral care implement configurations. The tuft insert 460 in this configuration further includes a portion that is attached to the partition 141 or to the base 61 that forms the tuft insert. If so, when constructing the head, the four slots can be separated into a plurality of sub-concavities as described above with respect to the architecture of Figures 7 and 8. This configuration provides a reusable or refillable type, in which 17 complex active inserts 55 are retained in the oral cavity to change the head grooves β & ^, A ', 〇 head, without the need for a method, such that ί 蔡 (4) The other-manufacturing of the health-care appliance 1 can be a configuration with an open recess, and a plurality of materials for oral care can be used to shape the additional manufacturing cost. Any of the commercially available polymers. "A single structure" and can include a wide range of types formed by polypropylene, so that the oral cavity appliance! (including the ruler to provide different advantageous shape and spacing) oral health care g oral health appliances i can have m two health For example, the oral care agent is delivered by the mouth to the groove 50 by a different rate. For example, the size of the individual groove 2 and the outer surface of the head 22, 24, 26 = two Γ ° The shape, the depth of the groove 50 and / or the included mouth:: the nature of the health, to control these rates. ', 15 slots 50 can have different sizes, 俾 adapt to different levels of accompanying this 'oral health care appliance 1 can have Different oral = active agent release properties, so that when and how much shed, the nature of the material in the groove can also be for the release rate and has 2. Advantages of two (or more) grooves A new treatment strategy or sensory impression will be provided for different approximate release rates from different grooves. For example, 5 if the oral care agent in the groove 5〇Α is faster than in the groove 50Β, then a positive sequence can be obtained. Effect. If the groove 5 contains teeth Spot = agent and Cao 50Β contains an antibacterial agent, which may be quite beneficial for controlling the total bacterial wood. Or, if the grooves 5〇Α and 5〇Β 20 1359642 3 have different silk flavors or concentrates The sensory component provides a modified flavor to the user. This flavor change can make the brush pleasant, or it can indicate that the user has brushed for a long time. 5 10 15 In one configuration, once the groove 5 is received, it is required The agent, the use of the head 2 〇 to distribute or release the oral health care active agent in the mouth. Winter f 2: when the fluid and / or chemical substances are in contact, it can be from its individual concave; The agent can be immersed in the active insert material ^ can be released into the mouth when brushing teeth. During the brushing process, the water and the groove in the =:::: 20 part of the contact. The contact of the agent inside. This: 珉', middle time The foamed oral health care active agent from the head 20 is concave _ 5 〇 = using different oral health care active agents in the same head ", sputum, with different therapeutic methods to provide synergistic benefits to the user and to treat oral diseases. ability. As described in the storage, oral care can be manufactured using a wide range of molding techniques, and a wide range of material specifications and parameters can be used to provide oral care implements having the desired properties. For example, in the example of the example, the oral protection (4) has a groove material that can be discarded after the oral health agent is used for permanent use. For example, but the above ". too: the examples are for illustrative purposes only, and are not intended to limit the scope of the invention, the other aspects I, advantages and changes", the person who knows the skill • Khan invented It will be understood at the time that such aspects and variations are within the scope of the present invention. BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a perspective view showing the structure of an oral health care appliance; FIG. 2 is a schematic view showing the surface of one of the oral health care implements of FIG. 1; The oral health care device phase, schematic view; the surface of the circle is the side view of the health care appliance of the figure _, Ξ Γ is a partial enlarged view of the head of the oral health care appliance of the second one; Fig. 5 is the oral health care appliance of the figure i Decompose the component diagram; select, for the insert shown in class (4) 5 (4) plug-in Figure 7 ^ perspective view of the selected head structure of the D-cavity health care device; Figure 8 is the selected head structure of the diagram containing the active oral health care agent Perspective view; health care device ^ 9 is a perspective view of the selected head structure of the D-cavity health care device; Figure 0 is a perspective view of the selected head structure containing the active oral health care agent; ... L health care device map; = for oral health appliances (4) Perspective view of the selection structure of the pile board Fig. 12 is a side view of the tufting head board of the oral health care appliance of Fig. 11. 1359642 5
10 1510 15
【主要元件符號說明】 1 口腔保健用具 10把手 20頭部 22第一表面 24第二表面 30 口腔保健元件 35潔牙元件 40頭部底座 41殼體 42垂直壁 43水平壁 44垂直壁 45薄膜 46垂直壁 48凹槽側 49外側 50凹槽 50A次凹槽 50B次凹槽 50C次凹槽 50D次凹槽 53水平壁 55活性插件 20[Main component symbol description] 1 Oral health care appliance 10 Handle 20 Head 22 First surface 24 Second surface 30 Oral health element 35 Dental element 40 Head base 41 Housing 42 Vertical wall 43 Horizontal wall 44 Vertical wall 45 Film 46 Vertical wall 48 groove side 49 outside 50 groove 50A times groove 50B times groove 50C times groove 50D times groove 53 horizontal wall 55 active insert 20
Claims (1)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11/626,855 US8075216B2 (en) | 2007-01-25 | 2007-01-25 | Oral care implement housing an oral care agent |
Publications (2)
Publication Number | Publication Date |
---|---|
TW200843669A TW200843669A (en) | 2008-11-16 |
TWI359642B true TWI359642B (en) | 2012-03-11 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TW097102586A TWI359642B (en) | 2007-01-25 | 2008-01-24 | Oral care implement housing an oral care agent |
Country Status (11)
Country | Link |
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US (1) | US8075216B2 (en) |
EP (1) | EP2117376B1 (en) |
CN (1) | CN101641032B (en) |
AU (1) | AU2008207970B2 (en) |
BR (1) | BRPI0807420A2 (en) |
CA (2) | CA2676400C (en) |
CO (1) | CO6210786A2 (en) |
MX (1) | MX2009007960A (en) |
RU (1) | RU2416348C1 (en) |
TW (1) | TWI359642B (en) |
WO (1) | WO2008091933A1 (en) |
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2007
- 2007-01-25 US US11/626,855 patent/US8075216B2/en active Active
-
2008
- 2008-01-23 CN CN200880009889.2A patent/CN101641032B/en not_active Expired - Fee Related
- 2008-01-23 WO PCT/US2008/051776 patent/WO2008091933A1/en active Application Filing
- 2008-01-23 MX MX2009007960A patent/MX2009007960A/en active IP Right Grant
- 2008-01-23 BR BRPI0807420-8A patent/BRPI0807420A2/en not_active Application Discontinuation
- 2008-01-23 RU RU2009131932/12A patent/RU2416348C1/en not_active IP Right Cessation
- 2008-01-23 EP EP08728115.0A patent/EP2117376B1/en active Active
- 2008-01-23 CA CA2676400A patent/CA2676400C/en not_active Expired - Fee Related
- 2008-01-23 CA CA2801869A patent/CA2801869A1/en not_active Abandoned
- 2008-01-23 AU AU2008207970A patent/AU2008207970B2/en not_active Ceased
- 2008-01-24 TW TW097102586A patent/TWI359642B/en not_active IP Right Cessation
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2009
- 2009-08-21 CO CO09088167A patent/CO6210786A2/en active IP Right Grant
Also Published As
Publication number | Publication date |
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CA2676400A1 (en) | 2008-07-31 |
CN101641032B (en) | 2014-07-30 |
EP2117376B1 (en) | 2017-11-15 |
MX2009007960A (en) | 2009-08-28 |
US20080181716A1 (en) | 2008-07-31 |
CO6210786A2 (en) | 2010-10-20 |
RU2416348C1 (en) | 2011-04-20 |
CA2801869A1 (en) | 2008-07-31 |
EP2117376A1 (en) | 2009-11-18 |
RU2009131932A (en) | 2011-02-27 |
WO2008091933A1 (en) | 2008-07-31 |
AU2008207970A1 (en) | 2008-07-31 |
BRPI0807420A2 (en) | 2014-05-27 |
AU2008207970B2 (en) | 2011-09-29 |
CA2676400C (en) | 2013-12-17 |
TW200843669A (en) | 2008-11-16 |
US8075216B2 (en) | 2011-12-13 |
CN101641032A (en) | 2010-02-03 |
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MM4A | Annulment or lapse of patent due to non-payment of fees |