JP2017169665A - Method for manufacturing medical tube - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a method for manufacturing a medical tube to which a biological material or medical liquid is less likely to adhere.SOLUTION: A method for manufacturing a medical tube is a method for manufacturing a tube having a micro concavo-convex structure on the inner surface, and includes an insertion process for inserting a core rod member into a tube member, an exhibition process for melting the outer surface of the core rod member and exhibiting a micro concavo-convex pattern, a filling process for putting a molding material into a gap between the tube member and the core rod member, formed by the melting of the outer surface of the core rod member, and an integration process for integrating the molding material into the inner surface of the tube member.SELECTED DRAWING: Figure 8

Description

  The present invention relates to a method for manufacturing a medical tube.

  Conventionally, it is possible to connect the outside of the body and the trachea directly to the patient who has difficulty in spontaneous breathing and difficult to discharge sputum by himself, to secure the airway and to suck in foreign matter such as breathing and sputum The tracheal tube is known.

  Such a tracheal tube is disclosed in Patent Document 1, for example. Specifically, Patent Document 1 discloses a lumen body provided with an airway securing lumen penetrating from a proximal end portion to a distal end portion, a connector portion formed at the proximal end portion of the lumen body, and the lumen body. A cuff that is formed on the outer periphery of the distal end side portion and capable of being expanded and contracted, a cuff inflation lumen that is formed on a wall portion that constitutes the lumen body and communicates between the surface portion of the connector portion and the inside of the cuff, and A tracheostomy tube is disclosed that includes a suction lumen formed on a wall portion constituting a lumen body and communicating the surface portion of the connector portion and the surface portion of the lumen body.

  In the tracheal tube disclosed in Patent Literature 1, by forming a suction lumen communicating with a predetermined portion on the surface of the lumen body from the surface of the connector portion on the wall portion of the lumen body, by suctioning from the connector portion side, The soot or the like accumulated between the lumen body and the trachea can be discharged to the outside through the suction lumen.

  Further, in the tracheal tube disclosed in the cited document 1, a coating that expresses surface lubricity when wet is formed on the surface of the tracheostomy tube and the inner surface forming the lumen for securing the airway of the lumen body. It is characterized by that. By adopting such a structure, when the inner surface of the luminal body is moistened due to breath or brim when the patient breathes, surface lubricity is developed, and soot or the like adheres to the inner surface of the luminal body. It is described that it becomes difficult.

JP 2006-102099 A

  However, as far as the present inventors have examined, it has been found that the tracheostomy tube described in Patent Document 1 still has room for further improvement regarding the suppression of sputum adhesion. In addition, for medical tubes used other than the tracheal tube, there is still room for further improvement in the suppression of adhesion of biological materials such as sputum or medical fluids such as infusion agents.

  An object of this invention is to provide the manufacturing method of the medical tube which a biological substance or a medical fluid does not adhere easily.

  The manufacturing method of the medical tube as the first aspect of the present invention is a manufacturing method of a tube having a fine concavo-convex structure on the inner surface, the inserting step of inserting a core rod member into the tube material, and the core rod member And a filling step of filling the gap between the tube material and the core rod member with a molding material, which is formed by melting the outer surface of the core rod to develop a fine uneven pattern and melting the outer surface of the core rod member And an integration step of integrating the molding material with the inner surface of the tube material.

  As one embodiment of the present invention, the core rod member is provided on the fine concavo-convex pattern, the core portion in which the fine concavo-convex pattern is formed on the outer surface and not soluble in a predetermined solvent that is water or an organic solvent, A surface layer part that dissolves in the predetermined solvent, and in the expression step, the surface layer part is preferably dissolved by the predetermined solvent.

  As one embodiment of the present invention, the core rod member includes a core portion having the fine uneven pattern formed on an outer surface, a surface layer portion provided on the fine uneven pattern, and having a lower melting point than the core portion, In the expression step, it is preferable to melt the surface layer portion by heating.

  As one embodiment of the present invention, the fine concavo-convex pattern includes convex ribs and concave grooves that extend in the axial direction of the core rod member and are alternately arranged in the circumferential direction of the core rod member. The core rod member is preferably removed in the axial direction after the molding material is integrated with the inner surface of the tube material.

  As one embodiment of the present invention, the fine concavo-convex pattern includes a plurality of recessed portions that are recessed toward the radially inner side of the core rod member, and the core rod member constitutes an outer surface of the core rod member. A sheet-shaped member, and a rod-shaped shaft core member around which the sheet-shaped member is wound on the outer surface, and after integrating the molding material on the inner surface of the tube material, the shaft core member is It is preferable to pull out from the sheet-like member and then peel off the sheet-like member from the molding material.

  As one embodiment of the present invention, it is preferable that the molding material is integrated with the inner surface of the tube material by heating.

  As one embodiment of the present invention, the molding material is preferably the same material as the molding material of the tube material.

  It is preferable that the manufacturing method of the medical tube as one embodiment of this invention further includes the coating process which performs a fluorine coating on the said molding material integrated with the inner surface of the said tube material.

  The method for producing a medical tube as the second aspect of the present invention is a method for producing a tube having a fine concavo-convex structure on the inner surface, and is provided on the core having a fine concavo-convex pattern on the outer surface and the fine concavo-convex pattern. A core rod member having a melting point lower than that of the core portion, an insertion step of inserting the core rod member into the tube material, and melting the melt target body of the core rod member, And a fusion integration step of integrating the melted body.

  ADVANTAGE OF THE INVENTION According to this invention, the manufacturing method of the medical tube which a biological material or a medical fluid cannot adhere easily can be provided.

It is a figure which shows the state which detained the tracheal tube manufactured using the manufacturing method of the medical tube as one Embodiment of this invention in the trachea. It is a perspective view which shows the tube main body of the tracheal tube shown in FIG. It is an expanded sectional view which shows the fine concavo-convex structure formed in the inner surface of the tube main body shown in FIG. It is the figure which looked at the tracheal tube shown in FIG. 1 from the base end side. It is sectional drawing which shows the cross section of the direction perpendicular | vertical to the central axis direction of the tube main body shown in FIG. It is an expanded view of the inner surface of the tube main body shown in FIG. FIG. 6A is a diagram showing a line and space structure, and FIG. 6B is a diagram showing a pillar structure. It is a figure which shows the formation flow of the medical tube as one Embodiment of this invention. It is a figure which shows the outline | summary of each process of the formation flow shown in FIG. It is a figure which shows the specific example of a core bar member. It is a figure which shows the specific example of a core bar member. It is a figure which shows the modification of a core bar member. It is a figure which shows the specific example of a core bar member. It is a figure which shows the formation flow of the medical tube as one Embodiment of this invention. It is a figure which shows the outline | summary of the fusion | melting integration process of FIG.

  Hereinafter, an embodiment of a method for manufacturing a medical tube according to the present invention will be described with reference to FIGS. Here, the manufacturing method of the tube main body as a medical tube used for a tracheal tube is demonstrated as an example of the manufacturing method of the medical tube which concerns on this invention. In addition, the same code | symbol is attached | subjected to the common member and site | part in each figure.

  First, an example of a tracheal tube manufactured using the method for manufacturing a medical tube according to the present invention will be described. FIG. 1 is a view showing a state in which a tracheal tube 1 as an example of a tracheal tube manufactured using the method for manufacturing a medical tube as one embodiment of the present invention is placed in the trachea. FIG. 2 is a perspective view showing a single tube body 2 as a medical tube in the tracheal tube 1. FIG. 3 is a part of a cross-sectional view of the tube main body 2 shown in FIG. 2, and is a view showing a fine concavo-convex structure 100 formed on the inner surface of the tube main body 2. FIG. 4 is a view of the tracheal tube 1 as seen from the proximal end side. As shown in FIG. 1, the tracheal tube 1 is attached to a tube body 2, a contractible and expandable cuff 3 attached on the outer peripheral surface of the tube body 2, and one end of the tube body 2. And a flange member 4.

  As shown in FIG. 2, the tube body 2 includes a distal end portion 8 including a distal end 5 and an extending direction of the central axis O1 of the inner surface of the tube main body 2 (hereinafter simply referred to as “central axial direction A”). A cuff mounting portion 9 that is continuous on the base end 6 side of the distal end portion 8 and to which the cuff 3 is attached on the outer peripheral surface, a bending portion 10 that is continuous on the base end 6 side of the cuff mounting portion 9, and the bending portion 10 A base end portion 11 that is continuous on the base end 6 side and includes the base end 6.

  The tube body 2 defines a hollow portion 7 that penetrates from the distal end 5 to the proximal end 6 in the central axial direction A. The tube main body 2 includes first to third lumens 12 to 14 that are formed in the wall and extend in the central axis direction A from a base end opening defined on the base end surface. The hollow portion 7 can secure an airway in a state where the tracheal tube 1 is inserted and indwelled from the outside into the trachea. The first lumen 12 extends from the first base end opening 12a to the suction port provided on the base end 6 side with respect to the cuff 3, and is upstream of the trachea than the cuff 3 in a state of being placed in the trachea. It is used for sucking and removing foreign substances X such as sputum, saliva, aspiration, blood, etc. stored on the jaw side. The second lumen 13 extends from the second proximal end opening 13a to a suction port provided on the distal end 5 side of the cuff 3, and is located downstream of the trachea (tracheal branch) from the cuff 3 placed in the trachea. Used to suck and remove foreign matter X such as wrinkles stored near the tip 8. The third lumen 14 extends from the third base end opening 14 a to the communication port 14 b provided at the position of the cuff 3 and is used for contracting and expanding the cuff 3. In addition, although it is a hollow part also about the small diameter 1st-3rd lumens 12-14 divided in the wall, in order to distinguish from the large diameter hollow part 7 for securing an airway for convenience of explanation, here, It is described as “lumen”.

  As shown in FIG. 3, a fine concavo-convex structure 100 is formed on the entire inner surface of the tube main body 2 as a medical tube. The fine concavo-convex structure 100 has a surface on which irregularities having a size of several μm to several hundreds of μm, preferably several μm to several tens of μm are formed. The fine concavo-convex structure 100 region has a property of suppressing wrinkle adhesion (hereinafter referred to as “repellency”). Details of the method of forming the fine relief structure 100 on the inner peripheral surface of the tube body 2 will be described later. The fine concavo-convex structure 100 may be formed over the entire inner peripheral surface of the tube body 2 or may be formed only on a part of the inner peripheral surface.

  A fluorine coat layer 200 is formed on the surface of the fine concavo-convex structure 100. The fluorine coat layer 200 is not particularly limited as long as it has a fluororesin as a main component. Examples of the fluororesin include polytetrafluoroethylene (PTFE), polychlorotrifluoroethylene (PCTFE, CTFE), polyvinylidene fluoride (PVDF), polyvinyl fluoride (PVF), perfluoroalkoxy fluororesin (PFA), tetrafluoroethylene. An ethylene / hexafluoropropylene copolymer (FEP), an ethylene / tetrafluoroethylene copolymer (ETFE), an ethylene / chlorotrifluoroethylene copolymer (ECTFE), or the like can be used.

  As a constituent material of the tube body 2, for example, polyvinyl chloride such as silicone and soft polyvinyl chloride, polyethylene, polypropylene, cyclic polyolefin, polystyrene, poly- (4-methylpentene-1), polycarbonate, acrylic resin, acrylonitrile- Various resins such as butadiene-styrene copolymer, polyester such as polyethylene terephthalate, butadiene-styrene copolymer, and polyamide (for example, nylon 6, nylon 6,6, nylon 6,10, nylon 12) can be used. . Among them, it is preferable to use a resin such as soft polyvinyl chloride, polypropylene, cyclic polyolefin, polyester, and poly- (4-methylpentene-1) because it is easy to mold.

  The cuff 3 is used to place the tracheal tube 1 at a predetermined position in the trachea. Specifically, the cuff 3 expands when a fluid is supplied through the third lumen 14 and contracts when the fluid is sucked. When the cuff 3 is expanded, the outer surface of the cuff 3 is in close contact with the inner wall of the trachea. The cuff 3 is held between the inner peripheral surface of the trachea and the like by the frictional force between the outer surface of the cuff 3 and the tracheal inner wall. In this way, the position of the cuff 3 in the trachea is fixed, and the tracheal tube 1 can be placed at a predetermined position in the trachea.

  As shown in FIG. 1, the flange member 4 is attached to the proximal end portion 11 (see FIG. 2) of the tube body 2. When the tube body 2 is inserted into the trachea from outside the body, the tracheal tube 1 is placed. The tip 8 is fixed at an appropriate position in the trachea by contacting the skin. As shown in FIGS. 1 and 4, the flange member 4 is a cylindrical tube that is fitted to the tube main body 2 when the proximal end portion 11 of the tube main body 2 is inserted and fitted to the tube main body 2. And a plate-like flange portion 18 that protrudes radially outward from the outer wall of the cylindrical portion 17 and abuts against the skin in a state where the tracheal tube 1 is indwelled. In FIG. 4, for convenience of explanation, the positions of the first lumen 12, the second lumen 13, and the third lumen 14 of the tube body 2 are indicated by a two-dot chain line.

  As shown in FIG. 4, the cylindrical portion 17 has communication holes 17 a and 17 b that communicate with the first lumen 12, the second lumen 13, and the third lumen 14, respectively, at positions proximal to the flange portion 18. , 17c. In the state where the proximal end portion 11 of the tube body 2 is fitted in the cylindrical portion 17, the first lumen 12, the second lumen 13, and the third lumen 14 have corresponding communication holes 17 a, 17 b, It communicates with the outside of the tracheal tube 1 via 17c, and a medical tube different from the tube body 2 is connected to each of the communication holes 17a, 17b, 17c.

  Specifically, the first lumen 12 communicates with the outside of the tracheal tube 1 on the proximal end side of the tracheal tube 1 through a corresponding communication hole 17 a formed in the cylindrical portion 17. Accordingly, if suction is performed by connecting a syringe or a suction pump to the other end of the suction tube 19a as a medical tube having one end fitted into the communication hole 17a of the cylindrical portion 17 exposed outside the body, A foreign substance X such as a bag can be sucked through the first lumen 12. Further, the second lumen 13 is the same as the first lumen 12, and the foreign substance X is sucked through the suction tube 19 b as a medical tube, the corresponding communication hole 17 b formed in the cylindrical portion 17, and the second lumen 13. can do.

  Further, the third lumen 14 communicates with the outside of the tracheal tube 1 on the proximal end side of the tracheal tube 1 through a corresponding communication hole 17 c formed in the cylindrical portion 17. Therefore, if a syringe or the like is connected to the other end of the cuff tube 19c as a medical tube whose one end is fitted to the communication hole 17c of the cylindrical portion 17 exposed outside the body, the operation of the syringe or the like outside the body The supply and suction of fluid to the annular space of the cuff 3 can be performed, whereby the expansion and contraction of the cuff 3 can be manipulated.

  The cylindrical portion 17 of the flange member 4 is mounted concentrically with the proximal end portion 11 of the tube body 2, and the position of the first lumen 12, the position of the second lumen 13 in the circumferential direction B of the tube body 2, The position of the third lumen 14 is set in the vicinity of the position in the circumferential direction B of the corresponding communication holes 17a, 17b, and 17c of the cylindrical portion 17. Therefore, each communicating hole 17a, 17b, 17c can be shortened, and it is suppressed that the structure of the communicating holes 17a, 17b, and 17c of the cylinder part 17 becomes complicated. As shown in FIG. 4, the suction tubes 19a and 19b and the cuff tube 19c are arranged in a direction in which the flange portion 18 protrudes from the communication holes 17a, 17b, and 17c in the plan view of FIG. It connects so that it may extend, and it does not extend to the front-end | tip part 8 side. By connecting in this way, in the state where the tracheal tube 1 is placed in the trachea, the suction tubes 19a and 19b and the cuff tube 19c are prevented from colliding with the patient's jaw and neck, and the tracheal tube The discomfort of the patient in which 1 is placed can be reduced.

  As a constituent material of the flange member 4, for example, it can be formed of the same material as that of the tube body 2.

<Method for manufacturing tube body 2>
Next, one Embodiment of the manufacturing method of the tube main body 2 as a medical tube mentioned above is described. FIG. 5 shows a cross-sectional view of the tube body 2 in a direction perpendicular to the central axis direction A (see FIG. 2). 5 is a cross-sectional view at a position where all of the first lumen 12, the second lumen 13, and the third lumen 14 are present in the central axis direction A of the tube main body 2. FIG. This manufacturing method is a manufacturing method of the tube main body 2 as a medical tube which has the fine concavo-convex structure 100 in the inner surface 31, as shown in FIG. The tube body 2 shown in FIG. 5 includes an outer layer 28a and an inner layer 28b. The outer layer 28a is a portion formed from a tube material 21 (see FIG. 8) described later, and the inner layer 28b is described later. It is a part formed from the molding material 60 (refer FIG. 8).

  The example of the uneven | corrugated pattern of the fine concavo-convex structure 100 formed in the inner surface 31 of the tube main body 2 as a medical tube is shown. FIG. 6 is an enlarged view of a part of the developed view of the inner surface 31 of the tube main body 2 as a medical tube. The horizontal direction in the figure indicates the central axis direction A of the tube main body 2 of the tracheal tube 1 and the vertical direction. Shows the circumferential direction B of the tube body 2 of the tracheal tube 1. As described above, the fine concavo-convex structure 100 is a concavo-convex structure having a size of several μm to several hundreds of μm, preferably several μm to several tens of μm. The uneven structure can take several uneven patterns. For example, as shown in FIG. 6A, a structure in which convex ribs 101 and concave grooves 102 extending in the central axis direction A of the tube body 2 are alternately arranged in the circumferential direction B (hereinafter simply referred to as “line”). And an "and-space structure"). Further, for example, as shown in FIG. 6B, a structure in which the truncated cone-shaped protrusions 103 are arranged in a predetermined arrangement (hereinafter simply referred to as “pillar structure”) can be employed. The line and space structure may be a structure in which the convex ribs 101 and the concave grooves 102 extending in the circumferential direction B are alternately arranged in the central axis direction A. However, foreign matter X such as wrinkles on the surface having a line-and-space structure (see FIG. 1) easily moves in the extending direction of the convex rib 101 and the concave groove 102, so that the foreign matter X remains in the tube body 2. It is preferable that the convex rib 101 and the concave groove 102 have a configuration shown in FIG. In addition, the shape of the protrusion 103 constituting the pillar structure is not limited to the truncated cone shape, and may be a cone shape, a columnar shape, a triangular pyramid shape, other polygonal pyramid shapes, a prismatic shape, or the like.

  Note that, as described above, the fine concavo-convex structure 100 is a concavo-convex structure having a size of several μm to several hundreds of μm, preferably several μm to several tens of μm. The distance between the centers of the ribs 101 or the projections 103 in the pillar structure (hereinafter, the convex ribs 101 and the projections 103 are simply referred to as “convex portions”) is preferably 10 μm to 100 μm, and 10 μm to 50 μm. Is more preferable. When it is larger than 100 μm, wrinkles easily enter between the convex portions, and the effect of repellency is reduced. On the other hand, when the thickness is less than 10 μm, the contact area between the ridge and the convex portion is increased, and the effect of repellency is reduced.

  Moreover, when the size of the fine concavo-convex structure 100 is the above conditions, the maximum width of the top surface 105 (see FIG. 3) of each convex portion is preferably 0.01 μm to 50 μm, and preferably 1 μm to 50 μm. More preferably, it is set to 1 μm to 30 μm, more preferably 1 μm to 20 μm. When it is larger than 50 μm, the contact area with the heel increases, and the repellency effect decreases. On the other hand, when the thickness is less than 0.01 μm, it is difficult to form the convex portion, and the shape stability may be lowered. When the fine concavo-convex structure 100 is a line and space structure, the maximum width of the top surface 105 (see FIG. 3) of each convex portion is the maximum length of the top surface 105 in the direction orthogonal to the extending direction of the convex ribs. Become.

  Furthermore, the size of the fine concavo-convex structure 100 is under the above conditions, and the maximum height of the convex portion of the fine concavo-convex structure 100 is several μm to several hundred μm, preferably several μm to several tens μm.

  FIG. 7 shows a flow of forming the tube main body 2 as a medical tube. Moreover, FIG. 8 is a figure which shows the outline | summary of each process of the formation flow of a medical tube shown in FIG.

  This manufacturing method includes an insertion step S1 for inserting the core rod member 22 into the tube material 21, an expression step S2 for melting the outer surface of the core rod member 22 to develop a fine uneven pattern 50, and an outer surface of the core rod member 22 A filling step S3 for filling the gap S between the tube material 21 and the core bar member 22 filled with the molding material 60 and an integration step S4 for integrating the molding material 60 on the inner surface of the tube material 21. And an extraction step S5 for extracting the core rod member 22 in the axial direction of the tube material 21 (here, the same direction as the axial direction C of the core rod member 22), and the molding material 60 integrated on the inner surface of the tube material 21 And a coating step S6 for forming the fluorine coat layer 200. Hereinafter, the respective steps will be described in detail with reference to FIG.

[Insertion step S1]
FIG. 8A and FIG. 8B are diagrams showing an outline of the insertion step S1. As shown in FIG. 8A, the core rod member 22 is inserted into the tube material 21 from one end to the other end of the tube material 21 (see the white arrow in FIG. 8A). In the tube material 21, the core bar member 22 is moved relative to the tube material 21 and moved to a predetermined position in the tube material 21. FIG. 8B shows a state in which the insertion step S1 has been completed.

  The tube material 21 does not have the fine uneven structure 100 (see FIGS. 3 and 6) on the inner surface, but has a smooth inner peripheral surface. The core bar member 22 has an outer diameter substantially equal to the inner diameter of the tube material 21, and is inserted into the tube material 21 while sliding with the inner surface of the tube material 21.

[Expression step S2]
FIG.8 (c) and FIG.8 (d) are the figures which show the outline | summary of the expression process S2. In the state shown in FIG. 8 (b), the outer surface of the core bar member 22 located in the tube material 21 is melted to develop the fine uneven pattern 50.

  Here, details of the core rod member 22 will be described. 9A to 9C are diagrams showing specific examples of the core rod member 22, and FIGS. 9A to 9C are each an outer surface of the cross section of the core rod member 22. It is the expanded sectional view which expanded some. In any of the specific examples shown in FIGS. 9A to 9C, the core bar member 22 includes a core portion 24 and a surface layer portion 45. On the outer surface of the core portion 24, a fine uneven pattern 50 is formed by inverting the line and space structure (see FIG. 6A) as the fine uneven structure 100 (see FIGS. 3 and 6). That is, the fine concavo-convex pattern 50 shown in FIG. 9 includes convex ribs 51 and concave grooves 52 that extend in the axial direction C of the core rod member 22 and are alternately arranged in the circumferential direction D of the core rod member 22. I have. The convex rib 51 is a portion corresponding to the concave groove 102 (see FIG. 6A) of the line and space structure as the fine concavo-convex structure 100, and the concave groove 52 is the line and space as the fine concavo-convex structure 100. This is a portion corresponding to the convex rib 101 of the structure (see FIG. 6A).

  The core portion 24 is insoluble in a predetermined solvent 70 that is water or an organic solvent. The surface layer portion 25 is provided on the fine concavo-convex pattern 50. Further, the surface layer portion 25 is soluble in the above-described predetermined solvent 70 in which the core portion 24 does not dissolve. The core rod member 22 shown in each of FIGS. 9A to 9C is provided with the surface layer portion 25 on the fine concavo-convex pattern 50 of the core portion 24, and thus the fine concavo-convex pattern 50 of the core portion 24. Is not completely exposed and has a smooth outer peripheral surface.

  Specific examples of the predetermined solvent 70 include water, acetone as an organic solvent, hexane, cyclohexanone, tetrahydrofuran, and the like. Further, as a constituent material of the core portion 24, a metal material such as stainless steel, a shape memory alloy such as nitinol, a fluorine resin (for example, Teflon (registered trademark)), a phenol resin, or the like having a property insoluble in the solvent 70 is used. be able to. When the organic solvent described above is used as the predetermined solvent 70, as a constituent material of the surface layer portion 25, soft polyvinyl chloride having a property of being soluble in these organic solvents can be used.

  As described above, the surface layer portion 25 is provided on the fine concavo-convex pattern 50 on the outer surface of the core portion 24. Specifically, in the example shown in FIG. 9A, the surface layer portion 25 is accommodated in the concave groove 52 in the fine concavo-convex pattern 50. Further, as in the example shown in FIG. 9B, the surface layer portion 25 is configured so as to cover both the convex ribs 51 and the concave grooves 52 while being accommodated in the concave grooves 52 of the fine uneven pattern 50. There may be. Furthermore, the surface layer portion 25 may be provided so as to cover the entire surface of the fine concavo-convex pattern 50. Alternatively, as in the example illustrated in FIG. 9C, the surface layer portion 25 is provided so as to cover both the convex ribs 51 and the concave grooves 52 without being accommodated in the concave grooves 52 of the fine uneven pattern 50. It may be. And the surface layer part 25 may be provided so that the area | region in which the fine uneven | corrugated pattern 50 was formed may be covered over the whole. However, the configuration of the surface layer portion 25 is not limited to the configuration shown in FIGS. 9A to 9C, and as will be described later, the fine uneven pattern 50 is expressed by melting the surface layer portion 25. Anything is acceptable.

  In addition, although FIG. 9 demonstrated the fine concavo-convex pattern 50 which reversed the fine concavo-convex structure 100 of the line and space structure (refer FIG. 6A), it is not restricted to this, For example, a pillar structure (FIG. 6 (b)), the relationship between the core portion 24 and the surface layer portion 25 shown in FIG. 9 can be realized. FIG. 10 is a diagram showing a fine concavo-convex pattern 50 ′ obtained by inverting the fine concavo-convex structure 100 having a pillar structure (see FIG. 6B). When the fine concavo-convex pattern 50 ′ obtained by inverting the fine concavo-convex structure 100 having the pillar structure (see FIG. 6B) is used, the fine concavo-convex pattern 50 ′ is formed with the diameter of the core rod member 22 as shown in FIG. What is necessary is just to set it as the structure provided with the some hollow part 54 dented toward the direction inner side. That is, the fine concavo-convex pattern 50 ′ may be configured by the outer peripheral surface 53 of the core portion 24 and a plurality of recessed portions 54 that are recessed from the outer peripheral surface toward the radially inner side. The recessed portion 54 is a portion corresponding to the pillar structure protrusion 103 (see FIG. 6B) as the fine concavo-convex structure 100.

  When the predetermined solvent 70 is attached to the outer surface of the core rod member 22, the surface layer portion 25 is dissolved by the solvent 70. On the other hand, the core part 24 does not dissolve in the solvent 70. Therefore, only the surface layer portion 25 of the core bar member 22 melts and volatilizes and disappears. Therefore, a fine uneven pattern 50 formed on the outer surface of the core portion 24 appears. In this way, the fine concavo-convex pattern 50 can be expressed by dissolving the surface layer portion 25 with the solvent 70, that is, dissolving at least a part of the outer surface of the core bar member 22.

  Returning to FIG. 8C and FIG. 8D again, the expression step S2 will be described. Here, FIGS. 8C to 8E are cross-sectional views taken along the line II of FIG. 8B. As shown in FIG.8 (c), the core part 24 of this embodiment has divided the hollow part 26 extended in the linear direction (the same direction as the axial direction C of the core rod member 22) of the core part 24. As shown in FIG. . Further, on the outer surface of the core portion 24, an ejection port 27 a communicating with the hollow portion 26 through the ejection hole 27 is formed. In the expression step S <b> 2, the predetermined solvent 70 is ejected from the ejection port 27 a through the hollow portion 26 and the ejection hole 27 of the core portion 24. By doing in this way, the surface layer part 25 of the core bar member 22 located between the inner surface of the tube material 21 and the outer surface of the core part 24 of the core bar member 22 can be melted by the predetermined solvent 70.

  8D, when the surface layer portion 25 is melted by the predetermined solvent 70, the fine uneven pattern 50 on the outer surface of the core portion 24 is exposed, and the inner surface of the tube member 21 and the outer surface of the core portion 24 are exposed. A gap S is formed between the fine concave / convex pattern 50. In other words, the gap S can be formed between the tube material 21 and the core bar member 22 by melting the outer surface of the core bar member 22.

  In addition, the method of supplying the solvent 70 between the inner surface of the tube material 21 and the outer surface of the core rod member 22 is not limited to the method of ejecting from the ejection port 27a. For example, the axial direction ( Here, the solvent 70 may be poured between the inner surface of the tube material 21 and the outer surface of the core bar member 22 from the position of the end surface in the same direction as the axial direction C of the core bar member 22.

[Filling step S3]
FIG. 8E is a diagram showing an outline of the filling step S3. As shown in FIG. 8E, in the filling step S3, the void 60 formed in the above-described expression step S2 is filled with the molding material 60 melted and fluidized by heating. Due to the molding material 60 filled in the gap S, the outer surface of the core portion 24 and the inner surface of the tube member 21, including the inside of the concave groove 52 (see FIG. 9) of the fine uneven pattern 50 (see FIG. 9) of the core portion 24. The space is filled. That is, a surface obtained by inverting the fine concavo-convex pattern 50, that is, the fine concavo-convex structure 100 (see FIGS. 3 and 6) is formed on the surface in contact with the fine concavo-convex pattern 50 in the molding material 60 filled in the gap S. Can do.

  In the filling step S <b> 3, the molding material 60 is filled into the gap S from the ejection port 27 a through the hollow portion 26 and the ejection hole 27 of the core portion 24. However, the filling method of the molding material 60 into the gap S is not limited to the filling method from the ejection port 27a. For example, the axial direction of the tube material 21 in the gap S (here, the axial direction C of the core rod member 22). In the same direction), that is, from the portion between the axial end surface of the tube material 21 and the core portion 24 of the core bar member 22, the molding material 60 is filled in the axial direction of the tube material 21. May be.

[Integration step S4]
FIG. 8F is a diagram showing an outline of the integration step S4. In the integration step S4, the molding material 60 filled in the gap S is integrated with the inner surface of the tube material 21. As shown in FIG. 8 (f), in this embodiment, the tube material 21, the core portion 24 of the core bar member 22, and the molding material 60 are placed outside the tube material 21 in the state shown in FIG. 8 (e). (See the wavy arrow in FIG. 8F), the molding material 60 is integrated with the inner surface of the tube material 21. As a heating device used for heating, for example, a radiant heat heater, an ultrasonic generator, or a high frequency generator can be used. As an example of the heating mode, for example, the tube material 21, the core portion 24 of the core bar member 22, and the molding material 60 in the state shown in FIG. 8E are put into an oven (not shown), Can be heated. The set temperature is preferably 100 to 180 degrees, more preferably 150 degrees. Note that the core rod member 22 shown in FIG. 8 (f) has only the core portion 24 because the surface layer portion 25 (see FIG. 8 (c)) is melted by the above-described expression step S <b> 2 inside the tube material 21. The portion exposed to the outside of the tube material 21 remains without melting the surface layer portion 25.

  The tube material 21 of this embodiment is comprised by the material which has the property softened by the heating from the outside, ie, the material which has thermoplasticity among the constituent materials of the tube main body 2 mentioned above. Therefore, the tube material 21 contracts by heating from the outside. Therefore, by heating from the outside, the tube material 21 is reduced in diameter, and the inner surface of the tube material 21 is in close contact with the molding material 60. Furthermore, the molding material 60 and the tube material 21 are integrated by fixing the tube material 21 to the molding material 60 in this way. Further, the tube material 21 and the molding material 60 may be more firmly integrated by melting the inner surface of the tube material 21 and the molding material 60 and welding them together.

  The molding material 60 filled in the gap S is preferably the same material as the molding material of the tube material 21. As described above, if the constituent material of the tube material 21 and the molding material 60 are the same material, and the inner surface of the tube material 21 and the molding material 60 are melted and welded, the tube material 21 and the molding material 60 are further strengthened. Can be integrated.

  In addition, as shown in FIG. 8 (f), in the case of integration by heating, since the core bar member 22 is inserted into the tube material 21, the molding material 60 is reduced when the tube material 21 is reduced in diameter. Can be pressed against the fine concavo-convex pattern 50 (see FIG. 9) on the outer surface of the core portion 24 of the core bar member 22. In other words, if it is integrated by heating, the molding material 60 can be integrated with the inner surface of the tube material 21, and the fine irregularity pattern 50 is inverted on the inner surface of the molding material 60, that is, the fine irregularity. The structure 100 (see FIGS. 3 and 6) can be more reliably formed.

  In the above example, integration by heating from the outside has been described. However, the present invention is not limited to this. For example, the molding material 60 is formed of an adhesive and the inner surface of the tube material 21 is formed. The molding material 60 may be integrated by adhesion.

[Extraction step S5]
FIG. 8G is a diagram showing an outline of the extraction step S5. When the molding material 60 is integrated with the inner surface of the tube material 21 by the integration step S <b> 4 described above, the original tube 28 serving as the original shape of the tube body 2 is molded by the tube material 21 and the solidified molding material 60. In other words, as shown in FIG. 8 (g), the original tube 28 is formed of the outer layer 28a formed by the tube material 21 and the solidified molding material 60, and the fine uneven structure 100 (FIG. 3, FIG. 3) is formed on the inner surface. And an inner layer 28b having a structure (see FIG. 6). In the extraction step S <b> 5, the core rod member 22, more specifically, the core portion 24 of the core rod member 22 is extracted from the original tube 28.

  More specifically, as shown in FIG. 8G, the core rod member 22 is in the same direction as the axial direction of the original tube 28 (here, the axial direction of the tube material 21 and the axial direction of the core rod member 22). ) (See the white arrow in FIG. 8G) and removed from the original tube 28.

  In particular, in the fine concavo-convex structure 100 formed on the inner surface of the original tube 28, that is, the inner surface of the inner layer 28b, convex ribs 101 and concave grooves 102 extending in the axial direction of the original tube 28 are alternately arranged in the circumferential direction. In the case of the arranged line and space structure (see FIG. 6A), as described above, the core rod member 22 is moved in the axial direction of the original tube 28 (the white arrow in FIG. 8G). It is easy to remove from the original tube 28).

  On the other hand, the fine concavo-convex structure 100 formed on the inner surface of the original tube 28, that is, the inner surface of the inner layer 28b is a pillar structure in which the frustoconical protrusions 103 are arranged in a predetermined arrangement (see FIG. 6B). ), The core bar member 22 is moved in the axial direction of the original tube 28 (see the white arrow in FIG. 8G), and it is difficult to extract from the original tube 28, and such extraction is performed. Then, there is a risk of damaging the fine concavo-convex structure 100.

  FIG. 11 is a view showing a core rod member 122 as a modification of the core rod member 22. As shown in FIG. 11, the core rod member 122 includes a sheet-like member 123 constituting the outer surface of the core rod member 122 and a rod-shaped shaft core member 124 around which the sheet-like member 123 is wound. ing. And the sheet-like member 123 is provided with the above-mentioned core part 24 and surface layer part 25 (refer FIG. 9 etc.). The sheet-like member 123 is thin (about 0.5 mm to 2 mm) and has flexibility. With such a configuration, in the extracting step S5, first, the shaft core member 124 is extracted from the sheet-like member 123, and then the sheet-like member 123 is folded or deformed radially inward to thereby deform the sheet-like member 123. Can be peeled off from the inner surface of the inner layer 28 b formed of the molding material 60. That is, all of the core bar member 122 can be taken out from the original tube 28 without sliding the fine uneven structure 100 on the inner surface of the inner layer 28 b and the core bar member 122.

  As described above, the core rod member 122 shown in FIG. 11 is particularly effective when the fine uneven structure 100 formed on the inner surface of the inner layer 28b has a pillar structure (see FIG. 6B). The core rod member 122 shown in FIG. 11 may be used when the fine uneven structure 100 has a line-and-space structure (see FIG. 6A).

[Coating process S6]
FIG. 8 (h) is a diagram showing an outline of the coating step S6. In the coating step S6, a fluorine coating is applied on the molding material 60 integrated on the inner surface of the tube material 21, that is, on the fine concavo-convex structure 100 (see FIGS. 3 and 6) on the inner surface of the original tube 28. A coat layer 200 (see FIG. 3) is formed. Specifically, as shown in FIG. 8H, a fluorine coating agent 90 containing the above-described fluororesin is applied to the surface of the fine concavo-convex structure 100. More specifically, the solvent containing the fluorine coating agent 90 is poured inside the original tube 28 and spreads over the entire region where the fine concavo-convex structure 100 is formed. However, the method for applying the fluorine coating agent 90 is not limited to the method shown in FIG. 8 (h), and a dip coating method in which the original tube 28 is immersed in a solvent containing the fluorine coating agent 90 is used. May be. Moreover, the method of spraying the solvent containing a fluorine coating agent with a spray, and the method of spreading using a scissors member may be sufficient.

  Next, in the coating step S6, the original tube 28 is dried in a state where the solvent containing the fluorine coating agent 90 is applied. The solvent is removed and a film of the fluorine coating agent 90 is formed. Next, the fluorine coating agent 90 is cured to form a bond with the fine concavo-convex structure 100. As an example of a mode of curing the fluorine coating agent 90, for example, the original tube 28 can be put into an oven (not shown) and cured by heating at a predetermined temperature for a predetermined time in the oven. The set temperature is preferably about 70 to 100 degrees, more preferably 80 degrees, and the heating time is preferably about 30 to 90 minutes. In this way, the fluorine coat layer 200 is formed on the surface of the fine concavo-convex structure 100.

  By applying a fluorine coating to the surface of the fine concavo-convex structure 100, the water repellency, oil repellency and friction resistance of the inner surface of the original tube 28 can be improved, and the strength of the fine concavo-convex structure 100 can be improved. Therefore, when the original tube 28 is further processed, the fine concavo-convex structure 100 can be hardly damaged.

  As described above, the original tube 28 having the fine concavo-convex structure 100 on the inner surface can be formed, and the original tube 28 is subjected to bending processing, finishing processing, and the like, thereby manufacturing the tube body 2 as a medical tube. can do. However, the original tube 28 itself formed by the above-described steps S1 to S6 can be a different medical tube from the tube body 2.

  In the manufacturing method of the tube main body 2 as the medical tube described so far, the core rod member 22 including the core portion 24 that does not dissolve in the predetermined solvent 70 and the surface layer portion 25 that dissolves in the same solvent 70 is used. The configuration of the core rod member 22 is not limited as long as the outer surface of the core rod member is melted to develop a fine uneven pattern. For example, as shown in FIG. 12, a core portion 24 ′ having a fine concavo-convex pattern 50 formed on the outer surface and a surface layer portion 25 ′ provided on the fine concavo-convex pattern 50 and having a lower melting point than the core portion 24 ′ It is also possible to use the core rod member 22 ′ provided. 12 (a), (b), and (c) are different from the core rod member 22 shown in FIGS. 9 (a), (b), and (c) in the constituent material. Except for the point, it has the same configuration.

  Hereinafter, for convenience of explanation, the predetermined melting point of the core portion 24 ′ will be described as “first melting point”, and the predetermined melting point of the surface layer portion 25 ′ lower than the first melting point will be described as “second melting point”. To do.

  When the core rod member 22 ′ shown in FIG. 12 is used, the core rod member is not used in the expression step S2 described above, but at a predetermined temperature higher than the second melting point and lower than the first melting point. Heat 22 '. Since this predetermined temperature is higher than the second melting point, the surface layer portion 25 ′ can be melted by heating. On the other hand, since the predetermined temperature is lower than the first melting point, the core portion 24 ′ is not melted. Only the surface layer portion 25 ′ of the core bar member 22 ′ is melted, volatilized and disappeared, thereby reversing the fine uneven structure 100 (see FIGS. 3 and 6) formed on the outer surface of the core portion 24 ′. A fine uneven pattern 50 appears. In this manner, the surface layer portion 25 ′ may be melted by heating, and the fine uneven pattern 50 may be developed on the outer surface of the core portion 24 ′.

  For example, among the constituent materials of the tube body 2 described above, polyethylene terephthalate having a relatively high melting point (melting point: about 250 degrees) is used as a constituent material for the core portion 24 ', and polystyrene having a relatively low melting point (melting point: about 100 degrees). Can be used as a constituent material of the surface layer portion 25 ′. Then, the core rod member 22 'is heated at a temperature higher than the second melting point (100 degrees) and lower than the first melting point (250 degrees), for example, 175 degrees, as the predetermined temperature. When the core rod member 22 ′ is heated at such a temperature, the surface layer portion 25 ′ composed of polystyrene melts and disappears, while the core portion 24 ′ composed of polyethylene terephthalate remains undissolved. In this way, the fine concavo-convex pattern 50 can be developed on the outer surface of the core portion 24 ′. However, the first melting point and the second melting point need only be in the above relationship, and the constituent material of the core portion 24 ′ and the constituent material of the surface layer portion 25 ′ are not limited to the materials described above. For example, the heat source is disposed outside the tube material 21, and the core bar member 22 ′ is heated from the outside of the tube material 21.

  In addition, even if it is a case where it replaces with the core rod member 22 and uses the core rod member 22 ', the process similar to process S1-S6 mentioned above except the point which heats without using the solvent 70 in expression process S2. The tube main body 2 can be manufactured by performing.

  Finally, a forming flow different from the forming flow shown in FIG. 7 will be described with reference to FIGS. FIG. 13 is a flow of forming the tube main body 2 described here, and FIG. 14 is a diagram showing an outline of the fusion integration step P2 in FIG. 13, and a part of the inner surface of the tube material 21 and the outer surface of the core bar member 322 It is an expanded sectional view which expands and shows.

  As shown in FIG. 13 and FIG. 14, the flow of forming the tube main body 2 described here is a core portion 324 having a fine unevenness pattern 50 on the outer surface, and provided on the fine unevenness pattern 50, and has a melting point higher than that of the core portion 324. The core rod member 322 having a low melted body 325 is inserted into the tube material 21 and the melted body 325 of the core rod member 322 is melted, and the melted body is formed on the inner surface of the tube material 21. A melt integration step P2 for integrating 325, a core portion 324 of the core rod member 322, an extraction step P3 for extracting in the axial direction of the tube material 21 (here, the same direction as the axial direction of the core rod member 322), and a tube And a coating step P4 for applying a fluorine coating on the melted body 325 integrated on the inner surface of the material 21. The insertion process P1 is the same as the insertion process S1 shown in FIG. 7, the removal process P3 is the same as the extraction process S5 shown in FIG. 7, and the coating process P4 is the same as the coating process S6 shown in FIG. . Therefore, description of the insertion process P1, the extraction process P3, and the coating process P4 is omitted here.

  The surface layer portion 25 and the surface layer portion 25 ′ described above are dissolved and disappeared by a solvent or heat, but the melted body 325 of the core bar member 322 is melted by heat but volatilized in the melt integration step P2. Without (disappearing), it is integrated with the inner surface of the tube material 21. As a heating device used for heating, for example, a radiant heat heater, an ultrasonic generator, or a high frequency generator can be used. Moreover, as a material for the to-be-melted body 325, the same thing as the material of the tube material 21 can be used. And as a material of the tube material 21 and the to-be-melted body 325, the constituent material of the tube main body 2 mentioned above can be used.

  In the core bar member 322 shown in FIG. 14, the melted body 325 is accommodated only in the concave groove 52 of the fine uneven pattern 50 of the core portion 324, but the melted body 325 is formed of the fine uneven pattern 50. The structure provided so that both the convex rib 51 and the ditch | groove 52 may be covered, being accommodated in the ditch | groove 52 may be sufficient.

  The method for manufacturing a medical tube according to the present invention is not limited to the specific method described in the above-described embodiment, and various modifications can be made without departing from the gist of the invention described in the claims. Is possible. For example, in the above-described embodiment, the method for manufacturing the tube body 2 as a medical tube has been described. However, the method for manufacturing a tube according to the present invention is not limited to the tube body of a tracheal tube, and is used for other applications and purposes. The present invention is also applicable as a method for manufacturing a medical tube.

  Examples of the medical tube that can be manufactured by the manufacturing method according to the present invention include (1) insertion or indwelling in the digestive organ orally or nasally, such as a gastric tube catheter, a nutrition catheter, or a tube feeding tube. Catheters; (2) Oxygen catheters, endotracheal tubes, intratracheal suction catheters, or other catheters that are orally or nasally inserted or placed in the respiratory tract or trachea; (3) urinary catheters, urinary catheters, urethral balloons (4) Catheters inserted or placed in various body cavities, organs, tissues such as suction catheter, drainage catheter, rectal catheter; (5) Infusion tube, IVH (abbreviation for intravenous hyperalimentation) catheter, thermodilu Catheters, angiographic catheters, vasodilator catheters and catheters that are inserted or placed indirectly or directly into blood vessels such as dilators or introducers; (6) medical artificials such as artificial trachea and artificial bronchi (7) Circuits for medical devices for extracorporeal circulation treatment (artificial lung, artificial heart, artificial kidney, etc.).

  According to various medical tubes manufactured by the manufacturing method according to the present invention, a wide range of biological substances or medical liquids can be prevented from adhering to the inner surface. Examples of the “biological substance” include whole blood, plasma, serum, sweat, stool, urine, saliva, tears, vaginal fluid, prostate fluid, gingival exudate, amniotic fluid, eye fluid, cerebrospinal fluid, semen , Sputum, ascites, pus, nasopharyngeal fluid, wound exudate, aqueous humor, vitreous humor, bile, earwax, endolymph, perilymph, gastric fluid, mucus, ascites, pleural effusion, sebum, vomit, and combinations thereof , Etc. Examples of the “medical liquid” include infusion agents, nutrients, contrast agents, embolic agents used in hepatic artery chemoembolization (TACE), and the like.

  The present invention relates to a method for manufacturing a medical tube.

1: Tracheal tube 2: Tube body (medical tube)
3: Cuff 4: Flange member 5: Tube body distal end 6: Tube body proximal end 7: Tube body hollow portion 8: Tube body distal end portion 9: Tube body distal end portion 10: Tube body cuff mounting portion 10: Tube body curved portion 11 : Base end 12 of the tube body: First lumen 12a: First base end opening 13: Second lumen 13a: Second base end opening 14: Third lumen 14a: Third base end opening 14b: Communication port 17: Tube Portions 17a, 17b, 17c: Communication hole 18: Flange portion 19a, 19b: Suction tube 19c: Cuff tube 21: Tube material 22, 22 ': Core bar member 24, 24': Core portion 25, 25 ': Surface layer Part 26: Hollow part 27: Ejection hole 27a: Outlet 28: Original tube 28a: Outer layer 28b of original tube: Inner layer 31 of original tube: Inner surface 50, 50 'of tube main body: Fine uneven pattern Down 51: convex rib 52: groove 53: the core outer peripheral surface 54 of the: recess portion 60: molding material 70: Solvent 90: fluorine coating agent 100: fine unevenness 101: convex rib (protrusion)
102: Groove 103: Projection (convex part)
105: Top surface 122: Core rod member 123: Sheet-like member 124: Shaft core member 200: Fluorine coating layer 322: Core rod member 324: Core portion 325: Melted body A: Direction B of central axis of inner surface of tube body : Circumferential direction of the tube body C: Axial direction of the core rod member D: Circumferential direction of the core rod member O1: Center axis line S of the inner surface of the tube body S: Air gap X: Foreign matter

Claims (9)

A method of manufacturing a tube having a fine relief structure on the inner surface,
An insertion step of inserting the core member into the tube material;
An expression step of melting the outer surface of the core bar member to develop a fine uneven pattern;
A filling step of filling a molding material into a gap between the tube material and the core rod member formed by melting the outer surface of the core rod member;
An integration step of integrating the molding material with the inner surface of the tube material. The core rod member has a fine uneven pattern formed on the outer surface thereof, a core portion that is insoluble in a predetermined solvent that is water or an organic solvent, and a surface layer portion that is provided on the fine uneven pattern and is soluble in the predetermined solvent. With
The method for manufacturing a tube according to claim 1, wherein in the expression step, the surface layer portion is dissolved by the predetermined solvent. The core bar member includes a core portion in which the fine concavo-convex pattern is formed on an outer surface, and a surface layer portion provided on the fine concavo-convex pattern and having a melting point lower than that of the core portion,
The manufacturing method of the tube of Claim 1 which melts | dissolves the said surface layer part by heating in the said expression process. The fine concavo-convex pattern includes convex ribs and concave grooves that extend in the axial direction of the core rod member and are alternately arranged in the circumferential direction of the core rod member.
The said core bar member is a manufacturing method of the tube as described in any one of Claims 1 thru | or 3 after extracting the said molding material in the inner surface of the said tube material, and then extracting in the said axial direction. The fine concavo-convex pattern includes a plurality of recessed portions that are recessed toward the radially inner side of the core bar member,
The core rod member includes a sheet-like member constituting the outer surface of the core rod member, and a rod-shaped shaft core member around which the sheet-like member is wound on the outer surface,
After integrating the molding material on the inner surface of the tube material, the shaft core member is removed from the sheet-like member, and then the sheet-like member is peeled off from the molding material. The manufacturing method of the tube as described in one.   The manufacturing method of the tube as described in any one of Claims 1 thru | or 5 which integrates the said molding material with the inner surface of the said tube material by heating.   The method for manufacturing a tube according to claim 1, wherein the molding material is the same material as the molding material of the tube material.   The method for producing a medical tube according to any one of claims 1 to 7, further comprising a coating step of applying a fluorine coating on the molding material integrated with the inner surface of the tube material. A method of manufacturing a tube having a fine relief structure on the inner surface,
An insertion step of inserting a core rod member having a core portion having a fine unevenness pattern on the outer surface and a melted body having a melting point lower than that of the core portion provided on the fine unevenness pattern into the tube material,
A melting and integrating step of melting the melt of the core bar member and integrating the melt to the inner surface of the tube material.

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