JP2017105767A - Capsule composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a capsule composition blended with an olive fruit extract which suppresses delayed disintegration.SOLUTION: There is provided a capsule composition which is filled with an olive fruit extract containing verbascoside as a content, wherein the capsule film contains no gelatin. Since a capsule composition blended with an olive fruit extract containing verbascoside which suppresses delayed disintegration can be provided, the capsule composition is useful in the fields of foods (especially supplements), medicines and quasi drugs, which are blended with an olive fruit extract containing verbascoside.SELECTED DRAWING: None

Description

  The present invention relates to a capsule composition containing an olive fruit extract that prevents a delay in disintegration time.

Olives are small evergreens belonging to the family Moleaceae, and have been closely related to people's lives in the Mediterranean region since ancient Greece, and have been widely used for food and medicine. It is known that olive fruit contains an antioxidant called Verbascoside or hydroxytyrosol, a kind of polyphenol. The olive fruit extract obtained from olive fruit has an active oxygen scavenging action, melanin It has been reported that it has a production inhibitory effect, tumor cell growth inhibitory / killing effect, and human leukocyte esterase inhibition (Patent Document 1). Therefore, olive fruit extract has attracted attention as a health food material.
On the other hand, capsules are made by encapsulating active ingredients such as pharmaceuticals, health materials, functional materials, etc. inside a film prepared using a solution such as protein such as gelatin, polysaccharides such as starch, etc. Hard capsules) and soft capsules (soft capsules). The dosage form is widely used in foods, pharmaceuticals, quasi-drugs, cosmetics, miscellaneous goods, etc. Especially, soft capsules have a wide range of uses because they can contain oily or pasty active ingredients. The soft capsule film is required to have shape stability during production and storage and storage stability of the contents, but on the other hand, it is required to rapidly disintegrate during use. Accordingly, in consideration of the above points, gelatin is mainly used as a film base, and gelatin containing a plasticizer or the like is mainly used as a film for soft capsules.
As a method for preventing the capsule disintegration delay, a method using a film in which gelatin, lecithin and citric acid are blended in a capsule skin is known (Patent Document 1).

JP2012-51945A

When the present inventors tried to prepare by filling olive fruit extract into a general capsule in providing a product containing olive fruit extract, the disintegration time was delayed over time (hereinafter referred to as disintegration delay). ) Was found. When the decay delay occurs, there is a concern that when the composition is ingested, the elution of the content is delayed and the components in the content are excreted without being digested and absorbed.
This invention is made | formed in view of the said background art, The subject is providing the capsule composition containing an olive fruit extract which prevented the decay | disintegration delay.

As a result of intensive studies to solve the above-mentioned problems, the present inventors have found that the cause of the delay in disintegration of the capsule composition is the interaction between the gelatin contained in the capsule film and the olive extract containing verbascoside. It was clarified that the cause was insolubilization of the capsule film.
Therefore, when the olive fruit extract containing verbascoside is included in the contents of the capsule composition, it has been found that by using a capsule film that does not contain gelatin, insolubilization of the capsule film can be prevented and disintegration delay can be prevented. It came to complete.

That is, the present invention
(1) A capsule composition filled with an olive fruit extract containing verbascoside as a content, wherein the capsule film does not contain gelatin,
It is.

  According to the present invention, an olive fruit extract containing verbascoside can be blended to prevent disintegration delay and to provide a high-quality capsule composition with good disintegration.

  The capsule coating of the present invention does not contain gelatin. Examples of the capsule composition include hard capsules and soft capsules, and soft capsules are preferable in terms of ease of taking. The component constituting the capsule film of the present invention is not particularly limited unless it contains gelatin. Examples of the main component of the capsule film include thickening polysaccharides, cellulose derivatives, starch and derivatives thereof, and other components include components that can be blended when preparing a normal capsule film such as plasticizer and water. Can be mentioned. Examples of the thickening polysaccharide include carrageenan (ι, λ, κ), locust bean gum, psyllium seed gum, tamarind seed gum, glucomannan, pectin, agar, alginic acids, xanthan gum, gellan gum, curdlan and pullulan. be able to. Examples of cellulose derivatives include hydroxypropyl methylcellulose and methylcellulose. Examples of the starch include corn starch, tapioca starch, potato starch, and wheat starch. Examples of the derivative include starch that has been treated with hydroxypropylation, acetylation, phosphorylation, octenyl succination and the like. Examples of the plasticizer include glycerin, polyethylene glycol, propylene glycol, polypropylene glycol, glucose, fructose, galactose, sucrose, maltose, trehalose, raffinose, pullulan, gum arabic, arabinogalactan, cellulose, sorbitol, maltitol, lactitol, and palatinit. Xylitol, mannitol, galactitol and the like.

  The olive fruit extract containing vervascoside of the present invention is an extract separated from natural olive (Olea europaea), and is commercially available OLEASELECT (extracted from olive fruit with a mixed solvent of water and ethanol and pulverized. , Total phenol content: 30% by mass or more, Verbascoside content: 5% by mass or more), OPEXTAN (pulverized from olive fruit with a mixed solvent of water and ethanol, total phenol content: 10% by mass or more Content, and a Verbascoside content of 2% by mass or more) can be used. The olive fruit extract of the present invention is preferably an olive fruit extract containing 2% by mass or more of Verbascoside.

  Although the compounding quantity of the olive fruit extract of this invention is not restrict | limited in particular, Preferably it is 1-50 mass% in the capsule composition of this invention, Preferably it is 4-50 mass%.

  What is necessary is just to manufacture the capsule composition of this invention in accordance with a conventional method. For example, if it is a soft capsule, according to well-known methods, such as a rotary die type, a seamless type, or a flat plate method, it should just manufacture using an additive suitably. A base oil, an emulsifier, a desired active ingredient-containing powder and the like are mixed with the olive fruit extract containing vervascoside of the present invention, and prepared according to a conventional method (for example, a method described in JP-A-2015-155384). it can. Moreover, there is no restriction | limiting in particular as said base oil, What is generally known as the content of a soft capsule can be used. Specifically, for example, soybean oil, sesame oil, corn oil, cottonseed oil, palm oil, palm oil, olive oil, peanut oil, rice bran oil, camellia oil, safflower oil, perilla oil, fish oil, EPA, DHA, medium chain fatty acid triglyceride Long chain fatty acid triglycerides and the like. The emulsifier is not particularly limited, and beeswax, carnauba wax, candelilla wax, rice bran wax, lecithin, glycerin fatty acid esters (acetic acid monoglyceride, lactic acid monoglyceride, citric acid monoglyceride, diacetyltartaric acid monoglyceride, succinic acid monoglyceride, polyglycerin fatty acid ester , Polyglycerin condensed linosyl acid ester, etc.), sucrose fatty acid esters and the like.

  In the case of hard capsules, the cap and body may be separated, filled with a mixture of olive fruit extract containing vervascoside of the present invention and appropriate additives, and the separated cap may be fitted.

  The present invention will be described in more detail with reference to the following examples, but the present invention is not limited to these examples.

(Preparation of contents for capsule filling)
The content base was prepared by dissolving the emulsifier in the warmed base oil and allowing to cool at room temperature. Capsule filling content by dispersing olive fruit extract (containing 5% Verbascoside) in the content base using a Teflon (registered trademark) homogenizer so that the concentration in the content base is 12.8% by mass It was a thing.

Test Example 1: Confirmation of effect of preventing film insolubilization 5 g of the above-mentioned content for capsule filling was weighed out into a screw test tube (10 mL). Further, a capsule prepared with a gelatin-free coating (mainly containing carrageenan and starch), and an empty capsule not filled with the contents cut into upper and lower halves from the joint (Example 1) and a gelatin-containing coating An empty capsule not filled with the contents, which was cut open in the upper and lower halves from the joint (Comparative Example 1), was poured so as to be immersed in the contents in the screw mouth test tube and capped. Thereafter, it was stored at 40 ° C. and 75% RH for 2 weeks. Moreover, as a control, the capsule capsule opened above was put into another empty screw test tube, capped, and stored at 40 ° C. and 75% RH for 2 weeks.
After storage, the soaked soft capsule film was taken out, the adhered contents were wiped off, and the disintegration time was confirmed according to the Japanese Pharmacopoeia General Test Method “Disintegration Test Method” (without auxiliary board) (n = 3). At the same time, the disintegration times of the one immediately after opening the empty capsule (hereinafter referred to as the immediately after product) and the above control were confirmed and compared. The disintegration time was the time when no residue was found in the glass tube. The test was conducted up to 120 minutes. The results are shown in Table 1.

As shown in Table 1, in Comparative Example 1 using a capsule film containing gelatin, the capsule film was not dissolved by immersing in the capsule filling content, whereas a significant delay in disintegration time was observed ( Comparison with Control 2) In Example 1, which is a capsule film not containing gelatin, almost no disintegration delay was observed (comparison with Control 1).
Further, it was shown that the decay delay due to temperature and humidity and storage period due to storage for 2 weeks in an environment of 40 ° C. and 75% RH was slight (Example 1, Control 1). From these results, it was found that the cause of the delay in the capsule film disintegration was the interaction between the olive fruit extract containing vervascoside and gelatin, and the insolubilization of the capsule film.

(Manufacture of soft capsule composition)
The content base was prepared by dissolving the emulsifier in the warmed base oil and allowing to cool at room temperature. Using a homogenizer, mix the olive fruit extract containing 5% or more of Verbascoside and the olive fruit extract not containing Verbascoside into the content base using a homogenizer so that the concentration in the content base is 12.8% by mass. Dispersed to obtain a capsule filling content in the form of a suspension. This capsule filling content was wrapped in a gelatin-free film (mainly containing carrageenan and starch) with a rotary die type soft capsule filling machine to give a soft capsule composition (Example 2). Similarly, the above suspension-filled contents for capsule filling were wrapped in a film containing gelatin to obtain a soft capsule composition (Comparative Example 2).

Test Example 2: Confirmation of soft capsule disintegration time (confirmation of film insolubilization prevention effect)
The soft capsule composition (Example 2, Comparative Example) immediately after production (stored at room temperature for 1 month, hereinafter referred to as product immediately after manufacture) and after stored for 2 months in RH at 40 ° C. and 75% (hereinafter referred to as product stored at 40 ° C. and 75% RH for 2 months) For 2), the disintegration time was confirmed according to the Japanese Pharmacopoeia General Test Method “Disintegration Test Method” (with auxiliary panel) (n = 6 for products immediately after production, n = 2 for 40 ° C. 75% RH stored products) Implemented). The disintegration time was defined as the time when the capsule film was opened and the contents were dispersed in the test solution, and the sample residue was not in its original form. The test is conducted for a maximum of 120 minutes, and in the test results of the same sample, when there were those that disintegrated within 120 minutes and those that did not disintegrate for 120 minutes or more, the disintegration time of those that did not disintegrate for 120 minutes or more The average value was calculated as 120 minutes. The results are shown in Table 2.

  As shown in Table 2, in the capsule composition using the film containing gelatin (Comparative Example 2), the disintegration time was remarkably long and a delay in the disintegration time was observed after storage, whereas the film containing no gelatin was used. In the capsule composition (Example 2), almost no disintegration delay after storage was observed. As a result, it was found that when an olive fruit extract containing verbascoside is included as the contents of the capsule composition, the interaction can be suppressed and the delay of disintegration can be prevented by using a capsule film containing no gelatin.

  INDUSTRIAL APPLICABILITY According to the present invention, it is possible to provide a capsule composition containing vervascoside-containing olive fruit extract that prevents the decay delay over time. Therefore, it is useful in the field of foods (particularly supplements), pharmaceuticals or quasi-drugs containing an olive fruit extract containing verbascoside.

Claims (1)

  A capsule composition filled with an olive fruit extract containing verbascoside as a content, wherein the capsule film does not contain gelatin.