JP2017070490A - Blood purification device - Google Patents

Abstract

PROBLEM TO BE SOLVED: To accurately measure a water removal amount with a simple configuration.SOLUTION: A blood purification device comprises: a blood purifier 120; a waste liquid pipe conduit 130 including a first branch path 131, a second branch path 132, and a third branch path 133; a dialysate pipe conduit 142; a replacement fluid pipe conduit 152; a first pump 160 that pumps out waste liquid 138 flowing through the first branch path 131 and dialysate 141 flowing through the dialysate pipe conduit 142 so that flow rates of the waste liquid and the dialysate are equal to each other; a second pump 161 that pumps out waste liquid 138 flowing through the second branch path 132 and replacement fluid 151 flowing through the replacement fluid pipe conduit 152 so that flow rates of the waste liquid and the replacement fluid are equal to each other; a third pump 162 that is connected to the third branch path 133 and pumps out waste liquid 138 flowing through the third branch path 133; a first valve 179 that opens/closes the third branch path 133; a first refuge pipe 134 through which waste liquid 138 temporarily flows; and a scale 139 that measures weight of waste liquid discharged from the waste liquid pipe conduit 130.SELECTED DRAWING: Figure 1

Description

  The present invention relates to a blood purification apparatus.

  As prior documents disclosing the configuration of the blood purification device, Japanese Patent Application Laid-Open No. 2001-541 (Patent Document 1), Japanese Patent Application Laid-Open No. 2006-95184 (Patent Document 2), and Japanese Patent Application Laid-Open No. 11-276578 (Patent Document). There is 3).

  The blood purification apparatus described in Patent Document 1 includes weight measuring means for measuring the total weight of the dialysate container and the filtrate container, and measurement of the total weight of the dialysate container and the filtrate container measured by the weight measuring means. The value obtained by subtracting the initial total weight measurement value measured at the start of blood treatment from the value and the water removal target value that increases with the treatment time according to the set water removal amount are compared until the difference between them becomes zero. By providing a control device that increases or decreases the rotation of the pump, the control accuracy of the water removal amount is improved. As the weight measuring means, two weighing scales, that is, a weighing scale for measuring the weight of the dialysate container and the replacement fluid container and a weighing scale for measuring the weight of the filtrate container are used.

  The blood purification apparatus described in Patent Document 2 includes a weighing scale that collectively measures the drainage storage container, the dialysate storage container, and the replacement fluid storage container. By measuring the amount of change in the total weight of the drainage storage container, the dialysate storage container, and the replacement fluid storage container with a weigh scale, the accuracy of measurement of the water removal amount is improved.

  The blood purification apparatus described in Patent Document 3 includes a dialysate measuring container, a drainage measuring container, and a replacement fluid measuring container, which are manufactured by plastic injection molding and have almost no error. . The flow rate of dialysate, drainage fluid, and replacement fluid is measured by detecting that the liquid level has passed in front of the sensors provided at the upper and lower portions of each weighing container. The filtrate flow rate and the drainage flow rate are accurately maintained by adjusting the rotation speed of the corresponding pump so that the obtained actual measurement value matches the set value.

JP 2001-541 A JP 2006-95184 A Japanese Patent Laid-Open No. 11-276578

  In the blood purification apparatus described in Patent Document 1, since two weight scales are used, improvement in control accuracy of the water removal amount is hindered due to a difference in measurement accuracy between the two weight scales.

  In the blood purification apparatus described in Patent Document 2, since the drainage storage container, the dialysate storage container, and the replacement fluid storage container are collectively measured by the weight scale, variation in the measurement accuracy of the weight scale is reduced. Therefore, a weigh scale must be produced based on strict design standards, and the blood purification apparatus cannot be easily configured.

  In the blood purification apparatus described in Patent Document 3, a measuring container with almost no manufacturing error must be used, and the blood purification apparatus cannot be simply configured.

  The present invention has been made in view of the above problems, and an object of the present invention is to provide a blood purification apparatus capable of accurately measuring the water removal amount with a simple configuration.

  A blood purification apparatus according to the present invention includes a blood purification device incorporated in a blood circuit, and a first branch path, a first branching passage, which is incorporated in the blood circuit, and divides and flows the drained liquid discharged from the blood purification device into three. A drainage line including two branch paths and a third branch path, a dialysate pipe line that is incorporated into the blood circuit and supplies dialysate into the blood purifier, and a blood circuit that is built into the blood circuit and from the blood purifier A replacement fluid line for supplying a replacement fluid to the upstream side or downstream side of the fluid, and a drain fluid flowing through the first branch channel and a dialysate flowing through the dialysate channel connected to each of the first branch channel and the dialysate channel. A first pump that pumps the fluid at an equal flow rate, and a second pump that is connected to each of the second branch channel and the replacement fluid conduit, and that pumps the drainage fluid flowing through the second branch channel and the fluid replacement fluid flowing through the fluid replacement fluid channel at an equal flow rate. , Connected to the third branch path, sending the drainage flowing through the third branch path A third pump to be discharged, a first valve provided downstream of the third pump in the third branch path, and connected to the third branch path between the third pump and the first valve, which opens and closes the third branch path And a first retraction pipe through which drainage flows temporarily and a scale for measuring the weight of the drainage discharged from the drainage pipe.

  In one embodiment of the present invention, the blood purification apparatus further includes a first liquid storage unit that is provided in the first retraction pipe and temporarily stores the drainage.

  In one aspect of the present invention, the blood purification apparatus is provided downstream of the second pump in the second branch path, and opens and closes the second branch path between the second pump and the second valve. And a second evacuation pipe connected to the second branch path and through which the drainage flows temporarily.

  In one embodiment of the present invention, the blood purification apparatus further includes a second liquid storage unit that is provided in the second retraction pipe and temporarily stores the drainage.

  According to the present invention, the water removal amount can be accurately measured with a simple configuration.

It is a circuit diagram which shows the structure of the blood purification apparatus which concerns on Embodiment 1 of this invention. In the blood purification apparatus which concerns on Embodiment 1 of this invention, it is a circuit diagram which shows the state which closed the 1st valve and opened the air valve. In the blood purification apparatus which concerns on Embodiment 1 of this invention, it is a circuit diagram which shows the state by which the waste_water | drain was stored in the 1st liquid storage part. In the blood purification apparatus which concerns on Embodiment 1 of this invention, it is a circuit diagram which shows the state which opened the 1st valve, closed the air valve, and operated the air pump. It is a circuit diagram which shows the structure of the blood purification apparatus which concerns on Embodiment 2 of this invention. In the blood purification apparatus which concerns on Embodiment 2 of this invention, it is a circuit diagram which shows the state which closed the 1st valve and the 2nd valve, and opened the 1st air valve, the 2nd air valve, and the 3rd air valve. In the blood purification apparatus which concerns on Embodiment 2 of this invention, it is a circuit diagram which shows the state which closed the 1st valve and the 2nd air valve, and opened the 2nd valve, the 1st air valve, and the 3rd air valve. In the blood purification apparatus which concerns on Embodiment 2 of this invention, it is a circuit diagram which shows the state which opened the 1st valve, the 2nd valve, the 2nd air valve, and the 3rd air valve, closed the 1st air valve, and operated the air pump. is there.

  Hereinafter, a blood purification apparatus according to each embodiment of the present invention will be described with reference to the drawings. In the following description of the embodiments, the same or corresponding parts in the drawings are denoted by the same reference numerals, and the description thereof will not be repeated. In the following description of the embodiments, a blood purification apparatus used for continuous slow blood replacement therapy (CRRT) will be described as a blood purification apparatus. However, the blood purification apparatus may be a blood purification apparatus used for continuous hemodiafiltration (CHDF).

(Embodiment 1)
FIG. 1 is a circuit diagram showing a configuration of a blood purification apparatus according to Embodiment 1 of the present invention. As shown in FIG. 1, the blood purification apparatus 100 according to Embodiment 1 of the present invention includes a blood purification device 120, a drainage line 130, a dialysate line 142, a replacement fluid line 152, and a first pump. 160, a second pump 161, a third pump 162, a first valve 179, a first retraction pipe 134, and a scale 139.

  Blood purifier 120 includes a semipermeable membrane made of, for example, a hollow fiber membrane. The blood purifier 120 has a blood inlet 121 and a blood outlet 122. An upstream blood duct 110 is connected to the blood inlet 121. A downstream blood conduit 116 is connected to the blood outlet 122.

  The upstream blood conduit 110 is provided with a blood pump 111 that delivers blood. An arterial drip chamber 112 is provided in the middle of the upstream blood conduit 110. The arterial drip chamber 112 is provided with an upstream pressure measuring device 113 for measuring blood pressure. Blood collected from the patient's artery is measured for pressure when passing through the arterial drip chamber 112 while flowing through the upstream blood conduit 110, and then flows into the blood purifier 120 from the blood inlet 121.

  A venous drip chamber 114 is provided in the middle of the downstream blood conduit 116. The venous drip chamber 114 is provided with a downstream pressure measuring device 115 that measures blood pressure. The blood purified by the blood purifier 120 is returned to the patient's vein after pressure is measured as it passes through the venous drip chamber 114 while flowing through the downstream blood line 116. As described above, the blood purifier 120 is incorporated in the blood circuit. The venous drip chamber 114 is connected to the replacement fluid line 152. The replacement fluid line 152 may be connected to the arterial drip chamber 112 instead of the venous drip chamber 114.

  The blood purifier 120 further has a dialysate inlet 124 and a drain outlet 123. A dialysate conduit 142 is connected to the dialysate inlet 124. A drainage conduit 130 is connected to the drainage outlet 123.

  The upstream end of the dialysate conduit 142 is connected to a dialysate supply unit 140 that supplies the dialysate 141. Connected to the dialysate conduit 142 is a first pump 160 that delivers dialysate 141 at a set flow rate Qd.

  The first pump 160 is a roller-type pump, and includes a rotor connected to the motor and three rollers attached to the rotor. The tube constituting the dialysate conduit 142 is wound around the rotor of the first pump 160. By rotating the rotor, the dialysate 141 in the tube is sent out as the rotor rotates while the roller closes the tube. The dialysate 141 that has flowed through the dialysate conduit 142 is supplied into the blood purifier 120. Thus, the dialysate conduit 142 is incorporated into the blood circuit.

  The upstream end of the replacement fluid line 152 is connected to a replacement fluid supply unit 150 that supplies the replacement fluid 151. Connected to the replacement fluid line 152 is a second pump 161 that delivers the replacement fluid 151 at a set flow rate Qs.

  The second pump 161 is a roller-type pump, and includes a rotor connected to the motor and three rollers attached to the rotor. The tube constituting the replacement fluid line 152 is wound around the rotor of the second pump 161. As the rotor rotates, the replacement fluid 151 in the tube is sent out as the rotor rotates while the roller presses the tube closed.

  The replacement fluid 151 that has flowed through the replacement fluid line 152 is supplied into the venous drip chamber 114. That is, the replacement fluid line 152 supplies the replacement fluid 151 to the downstream side of the blood circuit from the blood purifier 120. When the replacement fluid line 152 is connected to the arterial drip chamber 112, the replacement fluid line 152 supplies the replacement fluid 151 from the blood purifier 120 to the upstream side of the blood circuit. Thus, the replacement fluid line 152 is incorporated in the blood circuit.

  The drainage conduit 130 includes a first branch 131, a second branch 132, and a third branch 133 through which the drainage 138 discharged from the blood purifier 120 is divided into three. Thus, the drainage conduit 130 is incorporated in the blood circuit.

  Connected to the first branch 131 is a first pump 160 that pumps the drained liquid 138 at a set flow rate Qd. That is, the first pump 160 sends out the drainage liquid 138 flowing through the first branch 131 and the dialysate 141 flowing through the dialysate pipe 142 at equal flow rates.

  The tube constituting the first branch 131 is wound around the rotor of the first pump 160. As the rotor rotates, the roller discharges liquid 138 in the tube as the rotor rotates while pressing and closing the tube. The drainage liquid 138 that has flowed through the first branch 131 is discharged into the drainage container 137.

  Connected to the second branch 132 is a second pump 161 that pumps the drained liquid 138 at a set flow rate Qs. That is, the second pump 161 sends out the drainage 138 flowing through the second branch 132 and the replacement fluid 151 flowing through the replacement fluid line 152 at equal flow rates.

  The tube constituting the second branch path 132 is wound around the rotor of the second pump 161. As the rotor rotates, the roller discharges liquid 138 in the tube as the rotor rotates while pressing and closing the tube. The drainage liquid 138 that has flowed through the second branch path 132 is discharged into the drainage container 137.

  Connected to the third branch path 133 is a third pump 162 that pumps the drainage 138 flowing through the third branch path 133 at a set flow rate Qu. The third pump 162 is a roller pump. A first valve 179 that opens and closes the third branch path 133 is provided downstream of the third pump 162 in the third branch path 133. Between the third pump 162 and the first valve 179, the first branch pipe 134 through which the drainage liquid 138 temporarily flows is connected to the third branch path 133.

  In the present embodiment, blood purification apparatus 100 further includes a first liquid storage unit 135 that temporarily stores drainage 138. The first liquid storage part 135 is provided in the first retraction pipe 134. The 1st liquid storage part 135 may be comprised by the container, and may be comprised because the 1st evacuation pipe 134 is partially expanded in diameter.

  A first air supply pipe 136 is connected to the upper part of the first liquid storage part 135. The first air supply pipe 136 is connected to the air pipe 172 in the dialyzer 170 through the first air filter 175. The end of the air pipe 172 is open. A first air valve 173 that opens and closes the air pipe 172 is provided on the end side of the air pipe 172. A pressure gauge 174 and an air pump 171 for measuring the pressure in the air pipe 172 are connected between the first air filter 175 and the first air valve 173 in the air pipe 172.

  The scale 139 measures the weight of the drainage 138 discharged from the drainage conduit 130. That is, the weight of the drainage liquid 138 discharged into the drainage container 137 is measured.

  Hereinafter, the operation for measuring the water removal amount in the blood purification apparatus 100 according to the present embodiment will be described.

  First, as shown in FIG. 1, the first valve 179 is opened, and the first air valve 173 is closed while the air pump 171 is stopped. By operating the blood pump 111, the first pump 160, the second pump 161, and the third pump 162, the drainage 138 is discharged from the first branch 131 into the drainage container 137 at a flow rate Qd, and the second branch The drainage liquid 138 is discharged from the 132 into the drainage container 137 at the flow rate Qs, and the drainage liquid 138 is discharged from the third branch 133 into the drainage container 137 at the flow rate Qu. As a result, (Qd + Qs + Qu) can be measured by measuring the weight change of the drainage liquid 138 in the drainage container 137 with the balance 139.

  FIG. 2 is a circuit diagram showing a state where the first valve is closed and the first air valve is opened in the blood purification apparatus according to Embodiment 1 of the present invention. As shown in FIG. 2, the first valve 179 is closed, and the first air valve 173 is opened while the air pump 171 is stopped. As the blood pump 111, the first pump 160, the second pump 161, and the third pump 162 continue to operate, the drainage liquid 138 is discharged from the first branch 131 into the drainage container 137 at the flow rate Qd, and the second branch The drainage liquid 138 is discharged from the path 132 into the drainage container 137 at the flow rate Qs, the drainage of the drainage liquid 138 from the third branch path 133 is stopped, and the drainage liquid 138 flows into the first retraction pipe 134 at the flow rate Qu. . As a result, (Qd + Qs) can be measured by measuring the weight change of the drainage liquid 138 in the drainage container 137 with the balance 139.

  FIG. 3 is a circuit diagram showing a state in which the drainage is stored in the first liquid storage part in the blood purification apparatus according to Embodiment 1 of the present invention. As shown in FIG. 3, the drainage liquid 138 is caused to flow into the first retraction pipe 134 at a flow rate Qu until the drainage liquid 138 is stored in the first liquid storage part 135. It is not necessary to strictly grasp that the drainage liquid 138 is stored in the first liquid storage part 135. For example, it is predicted that about 80% of the first liquid storage part 135 is filled with the drainage liquid 138. The drainage liquid 138 is caused to flow into the first evacuation pipe 134 at a flow rate Qu until time is reached. Therefore, the first liquid storage part 135 does not need to be precisely manufactured.

  FIG. 4 is a circuit diagram showing a state where the first valve is opened, the air valve is closed, and the air pump is operated in the blood purification apparatus according to Embodiment 1 of the present invention. As shown in FIG. 4, the first valve 179 is opened, the first air valve 173 is closed, and the air pump 171 is operated, whereby air is supplied into the air pipe 172 at a flow rate Pa.

  The air supplied into the air pipe 172 passes through the first air filter 175 and then flows into the upper part of the first liquid storage part 135. By the air flowing into the first liquid storage part 135, the drainage liquid 138 in the first liquid storage part 135 is pushed out to the first retraction pipe 134 and flows through the first retraction pipe 134 at a flow rate Qx. The drainage liquid 138 that has flowed through the first retraction pipe 134 joins the drainage liquid 138 that flows through the third branch path 133 and is discharged into the drainage container 137.

  After all the drainage liquid 138 in the first liquid storage part 135 is discharged and a decrease in the measured value of the pressure gauge 174 is confirmed, the air pump 171 is stopped. This returns to the state shown in FIG. The actual flow rate Qu can be calculated by subtracting the measured value of (Qd + Qs + Qu) and the measured value of (Qd + Qs) obtained by the above series of operations.

  If there is a difference between the actual flow rate Qu and the set flow rate Qu, the output of the third pump 162 is adjusted. Specifically, when the actual flow rate Qu is larger than the set flow rate Qu, the output of the third pump 162 is lowered. When the actual flow rate Qu is smaller than the set flow rate Qu, the output of the third pump 162 is increased. Thus, it is preferable that the blood purification apparatus 100 includes a control unit that automatically adjusts the output of the third pump 162 based on the actual measurement value of the flow rate Qu.

  The water removal amount can be accurately measured from the product of the operating time of the blood purification apparatus 100 and the actual flow rate Qu. By repeating the above series of operations at regular intervals, the water removal amount can be accurately maintained. The blood purification apparatus 100 according to the present embodiment has a simple configuration because the water removal amount can be accurately measured only by measuring the weight change of the drainage liquid 138 in one drainage container 137 with the scale 139.

  The blood purification apparatus 100 according to the present embodiment has a configuration in which the drainage liquid 138 that has flowed into the first retraction pipe 134 is temporarily stored in the first liquid storage part 135, but the first liquid storage is not necessarily performed. It is not necessary to have the portion 135, and the drainage liquid 138 that has flowed to the first retraction pipe 134 may be configured to be discharged to a drainage pipe provided outside the drainage container 137. In this case, a valve for opening and closing the first retraction pipe 134 is required instead of the first air valve 173, but it is not necessary to provide the air pump 171 and the pressure gauge 174, so that the configuration of the blood purification apparatus 100 is further simplified. be able to.

  Hereinafter, a blood purification apparatus according to Embodiment 2 of the present invention will be described. The blood purification apparatus 200 according to Embodiment 2 of the present invention is mainly based on the point that the second valve 279 and the second retraction pipe 234 are provided in the second branch 132. Therefore, the same reference numerals are assigned to the same components as those of the blood purification device 100 according to the first embodiment, and the description thereof will not be repeated.

(Embodiment 2)
FIG. 5 is a circuit diagram showing a configuration of a blood purification apparatus according to Embodiment 2 of the present invention. As shown in FIG. 5, the blood purification apparatus 200 according to Embodiment 2 of the present invention further includes a second valve 279 and a second retraction pipe 234.

  A second valve 279 that opens and closes the second branch path 132 is provided downstream of the second pump 161 in the second branch path 132. Between the second pump 161 and the second valve 279, a second retraction pipe 234 through which the drainage liquid 138 flows temporarily is connected to the second branch path 132.

  In the present embodiment, blood purification apparatus 200 further includes a second liquid storage unit 235 that temporarily stores drainage 138. The second liquid storage unit 235 is provided in the second retraction pipe 234. The 2nd liquid storage part 235 may be comprised by the container, and may be comprised because the 2nd evacuation pipe 234 is partially expanded in diameter.

  A second air supply pipe 236 is connected to the upper part of the second liquid reservoir 235. The second air supply pipe 236 is connected to the first air branch pipe 271 in the dialyzer 270 through the second air filter 275. The first air branch pipe 271 is connected to the tip of the air pipe 172. The first air branch pipe 271 is provided with a second air valve 273 that opens and closes the first air branch pipe 271.

  The first air supply pipe 136 is connected to the second air branch pipe 272 in the dialyzer 270 through the first air filter 175. The second air branch pipe 272 is connected to the tip of the air pipe 172. The second air branch pipe 272 is provided with a third air valve 274 that opens and closes the first air branch pipe 271.

  Hereinafter, in the blood purification apparatus 200 according to the present embodiment, an operation for measuring the water removal amount will be described.

  First, as shown in FIG. 5, the first valve 179 and the second valve 279 are opened, and the first air valve 173, the second air valve 273, and the third air valve 274 are closed while the air pump 171 is stopped. To.

  By operating the blood pump 111, the first pump 160, the second pump 161, and the third pump 162, the drainage 138 is discharged from the first branch 131 into the drainage container 137 at a flow rate Qd, and the second branch The drainage liquid 138 is discharged from the 132 into the drainage container 137 at the flow rate Qs, and the drainage liquid 138 is discharged from the third branch 133 into the drainage container 137 at the flow rate Qu. As a result, (Qd + Qs + Qu) can be measured by measuring the weight change of the drainage liquid 138 in the drainage container 137 with the balance 139.

  FIG. 6 is a circuit diagram showing a state where the first valve, the second valve are closed, and the first air valve, the second air valve, and the third air valve are opened in the blood purification apparatus according to Embodiment 2 of the present invention. As shown in FIG. 6, the first valve 179 and the second valve 279 are closed, and the first air valve 173, the second air valve 273, and the third air valve 274 are opened while the air pump 171 is stopped. .

  As the blood pump 111, the first pump 160, the second pump 161, and the third pump 162 continue to operate, the drainage liquid 138 is discharged from the first branch 131 into the drainage container 137 at the flow rate Qd, and the second branch The drainage of the drainage liquid 138 from the passage 132 stops, the drainage liquid 138 flows into the second retraction pipe 234 at the flow rate Qs, and the drainage of the drainage liquid 138 from the third branch path 133 stops. Drainage liquid 138 flows in at a flow rate Qu. As a result, Qd can be measured by measuring the weight change of the drainage liquid 138 in the drainage container 137 with the balance 139.

  FIG. 7 is a circuit diagram showing a state where the first valve and the second air valve are closed and the second valve, the first air valve and the third air valve are opened in the blood purification apparatus according to Embodiment 2 of the present invention. As shown in FIG. 7, the first valve 179 and the second air valve 273 are closed, and the second valve 279, the first air valve 173 and the third air valve 274 are opened while the air pump 171 is stopped. .

  As the blood pump 111, the first pump 160, the second pump 161, and the third pump 162 continue to operate, the drainage liquid 138 is discharged from the first branch 131 into the drainage container 137 at the flow rate Qd, and the second branch The drainage liquid 138 is discharged from the path 132 into the drainage container 137 at the flow rate Qs, and the drainage liquid 138 in the third branch path 133 flows into the first retraction pipe 134 at the flow rate Qu. As shown in FIG. 7, the drainage liquid 138 is caused to flow into the first retraction pipe 134 at a flow rate Qu until the drainage liquid 138 is stored in the first liquid storage part 135. As a result, (Qd + Qs) can be measured by measuring the weight change of the drainage liquid 138 in the drainage container 137 with the balance 139.

  FIG. 8 shows a state in which the first valve, the second valve, the second air valve, and the third air valve are opened, the first air valve is closed, and the air pump is operated in the blood purification apparatus according to Embodiment 2 of the present invention. FIG. As shown in FIG. 8, the first valve 179, the second valve 279, the second air valve 273, and the third air valve 274 are opened, the first air valve 173 is closed, and the air pump 171 is operated. Air is supplied at a flow rate Pa.

  A part of the air supplied into the air pipe 172 flows into the upper part of the second liquid reservoir 235 after passing through the first air branch pipe 271 and the second air filter 275. Due to the air flowing into the second liquid storage part 235, the drainage liquid 138 in the second liquid storage part 235 is pushed out to the second retraction pipe 234 and flows through the second retraction pipe 234 at a flow rate Qz. The drainage liquid 138 that has flowed through the second retraction pipe 234 joins the drainage liquid 138 that flows through the second branch path 132 and is discharged into the drainage container 137.

  The remainder of the air supplied into the air pipe 172 flows into the upper part of the first liquid storage part 135 after passing through the second air branch pipe 272 and the first air filter 175. By the air flowing into the first liquid storage part 135, the drainage liquid 138 in the first liquid storage part 135 is pushed out to the first retraction pipe 134 and flows through the first retraction pipe 134 at the flow rate Qy. The drainage liquid 138 that has flowed through the first retraction pipe 134 joins the drainage liquid 138 that flows through the third branch path 133 and is discharged into the drainage container 137.

  After all the drainage liquid 138 in the second liquid storage part 235 is discharged and the decrease in the measured value of the pressure gauge 174 is confirmed, the second air valve 273 is closed. After all of the drainage 138 in the first liquid storage part 135 is discharged and a decrease in the measured value of the pressure gauge 174 is confirmed, the third air valve 274 is closed and the air pump 171 is stopped. This returns to the state shown in FIG.

  The actual flow rate Qu can be calculated by subtracting the measured value of (Qd + Qs + Qu) and the measured value of (Qd + Qs) obtained by the above series of operations. Further, the actual flow rate Qs can be calculated by subtracting the measured value of (Qd + Qs) and the measured value of Qd. That is, in the blood purification apparatus 200 according to the present embodiment, all of the actual flow rate Qd, the actual flow rate Qs, and the actual flow rate Qu can be measured.

  If there is a difference between the actual flow rate Qd and the set flow rate Qd, the output of the first pump 160 is adjusted. Specifically, when the actual flow rate Qd is larger than the set flow rate Qd, the output of the first pump 160 is lowered. When the actual flow rate Qd is smaller than the set flow rate Qd, the output of the first pump 160 is increased. As described above, it is preferable that the blood purification apparatus 200 includes a control unit that automatically adjusts the output of the first pump 160 based on the actual measurement value of the flow rate Qd.

  If there is a difference between the actual flow rate Qs and the set flow rate Qs, the output of the second pump 161 is adjusted. Specifically, when the actual flow rate Qs is larger than the set flow rate Qs, the output of the second pump 161 is lowered. When the actual flow rate Qs is smaller than the set flow rate Qs, the output of the second pump 161 is increased. Thus, it is preferable that the blood purification apparatus 200 includes a control unit that automatically adjusts the output of the second pump 161 based on the actual measurement value of the flow rate Qs.

  If there is a difference between the actual flow rate Qu and the set flow rate Qu, the output of the third pump 162 is adjusted. Specifically, when the actual flow rate Qu is larger than the set flow rate Qu, the output of the third pump 162 is lowered. When the actual flow rate Qu is smaller than the set flow rate Qu, the output of the third pump 162 is increased. As described above, it is preferable that the blood purification apparatus 200 includes a control unit that automatically adjusts the output of the third pump 162 based on the actual measurement value of the flow rate Qu.

  The water removal amount can be accurately measured from the product of the operating time of the blood purification apparatus 200 and the actual flow rate Qu. By repeating the above series of operations at regular intervals, the water removal amount can be accurately maintained. The blood purification apparatus 200 according to the present embodiment has a simple configuration because the water removal amount can be accurately measured only by measuring the weight change of the drainage liquid 138 in one drainage container 137 with the scale 139.

  The blood purification apparatus 200 according to the present embodiment has a configuration in which the drainage liquid 138 that has flowed into the first retraction pipe 134 is temporarily stored in the first liquid storage part 135, but the first liquid storage is not necessarily performed. It is not necessary to have the portion 135, and the drainage liquid 138 that has flowed to the first retraction pipe 134 may be configured to be discharged to a drainage pipe provided outside the drainage container 137. Similarly, the drainage liquid 138 that has flowed into the second retraction pipe 234 is temporarily stored in the second liquid storage part 235, but the second liquid storage part 235 is not necessarily required. 2 It may be configured to discharge the drainage liquid 138 that has flowed to the retraction pipe 234 to a drainage pipe provided outside the drainage container 137.

  In this case, in place of the second air valve 273 and the third air valve 274, two valves for opening and closing the first retraction pipe 134 and the second retraction pipe 234 are necessary, but it is necessary to provide an air pump 171 and a pressure gauge 174, etc. Therefore, the configuration of the blood purification apparatus 200 can be further simplified.

  In addition, the said embodiment disclosed this time is an illustration in all the points, Comprising: It does not become a basis of limited interpretation. Therefore, the technical scope of the present invention is not interpreted only by the above-described embodiments, but is defined based on the description of the scope of claims. Further, all modifications within the meaning and scope equivalent to the scope of the claims are included.

  DESCRIPTION OF SYMBOLS 100,200 Blood purification apparatus, 110 Upstream blood line, 111 Blood pump, 112 Arterial side drip chamber, 113 Upstream pressure measuring apparatus, 114 Venous drip chamber, 115 Downstream pressure measuring apparatus, 116 Downstream blood line , 120 Blood purifier, 121 Blood inlet, 122 Blood outlet, 123 Drain outlet, 124 Dialysate inlet, 130 Drain pipe, 131 First branch, 132 Second branch, 133 Third branch, 134 DESCRIPTION OF SYMBOLS 1 Retraction pipe, 135 1st liquid storage part, 136 1st air supply piping, 137 drainage container, 138 drainage, 139 scale, 140 dialysate supply part, 141 dialysate, 142 dialysate line, 150 supplementary liquid supply part , 151 fluid replacement, 152 fluid replacement conduit, 160 first pump, 161 second pump, 162 third pump, 171 air pump 172 Air piping, 173 1st air valve, 174 Pressure gauge, 175 1st air filter, 179 1st valve, 234 2nd retraction pipe, 235 2nd liquid storage part, 236 2nd air supply piping, 271 1st air branch piping 272 Second air branch pipe, 273 Second air valve, 274 Third air valve, 275 Second air filter, 279 Second valve.

Claims (4)

A blood purifier built into the blood circuit;
A drainage line including a first branch path, a second branch path, and a third branch path, which is incorporated into the blood circuit and flows the drained liquid discharged from the blood purifier into three parts;
A dialysate line that is incorporated into the blood circuit and supplies dialysate into the blood purifier;
A replacement fluid line that is incorporated in the blood circuit and supplies the replacement fluid to the upstream side or downstream side of the blood circuit from the blood purifier;
A first pump connected to each of the first branch passage and the dialysate conduit, and for sending the drainage fluid flowing through the first branch passage and the dialysate fluid flowing through the dialysate conduit at an equal flow rate;
A second pump connected to each of the second branch path and the replacement fluid line, and for sending out the drainage fluid flowing through the second branch path and the replacement fluid flowing through the replacement fluid path at equal flow rates;
A third pump connected to the third branch path and for sending out the drainage flowing through the third branch path;
A first valve that is provided downstream of the third pump in the third branch path and opens and closes the third branch path;
A first retraction pipe connected to the third branch path between the third pump and the first valve;
A blood purification apparatus comprising: a scale for measuring the weight of the drainage discharged from the drainage conduit.   The blood purification apparatus according to claim 1, further comprising a first liquid storage unit that is provided in the first retraction pipe and temporarily stores the drainage. A second valve provided on the downstream side of the second pump in the second branch path to open and close the second branch path;
3. The blood purification according to claim 1, further comprising a second retraction pipe connected to the second branch path between the second pump and the second valve and through which a drainage fluid temporarily flows. apparatus.   The blood purification apparatus according to claim 3, further comprising a second liquid storage unit that is provided in the second retraction pipe and temporarily stores the drainage.

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