JP2016540773A5 - - Google Patents
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- Publication number
- JP2016540773A5 JP2016540773A5 JP2016536710A JP2016536710A JP2016540773A5 JP 2016540773 A5 JP2016540773 A5 JP 2016540773A5 JP 2016536710 A JP2016536710 A JP 2016536710A JP 2016536710 A JP2016536710 A JP 2016536710A JP 2016540773 A5 JP2016540773 A5 JP 2016540773A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- cancer
- compound
- pharmaceutically acceptable
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 *c1cc2nc(N)c(C(NN)=O)[n]2nc1* Chemical compound *c1cc2nc(N)c(C(NN)=O)[n]2nc1* 0.000 description 52
- NHRCDBNBRQOQCJ-UHFFFAOYSA-N CCOc(ccnc1)c1NC(c1c(cccc2)[n]2nc1N)=O Chemical compound CCOc(ccnc1)c1NC(c1c(cccc2)[n]2nc1N)=O NHRCDBNBRQOQCJ-UHFFFAOYSA-N 0.000 description 2
- DSEDUUFHHGXVHG-UHFFFAOYSA-N CN(CC1)CCC1Oc(ccnc1)c1NC(c1c(N)nc2[n]1nc(C(F)(F)F)cc2)=O Chemical compound CN(CC1)CCC1Oc(ccnc1)c1NC(c1c(N)nc2[n]1nc(C(F)(F)F)cc2)=O DSEDUUFHHGXVHG-UHFFFAOYSA-N 0.000 description 2
- MIMBKZPNNFLXDB-UHFFFAOYSA-N CN(CC1)CCC1Oc(ccnc1)c1NC(c1c(N)nc2[n]1nccc2)=O Chemical compound CN(CC1)CCC1Oc(ccnc1)c1NC(c1c(N)nc2[n]1nccc2)=O MIMBKZPNNFLXDB-UHFFFAOYSA-N 0.000 description 2
- SGFTYMGAFPRPNP-UHFFFAOYSA-N CN(CC1)CCN1C(C(CC1)CCN1c(c(F)cnc1)c1NC(c1c(cccc2)[n]2nc1N)=O)=O Chemical compound CN(CC1)CCN1C(C(CC1)CCN1c(c(F)cnc1)c1NC(c1c(cccc2)[n]2nc1N)=O)=O SGFTYMGAFPRPNP-UHFFFAOYSA-N 0.000 description 2
- VOTOWVOBHDEJEB-UHFFFAOYSA-N Nc1n[n](cccc2)c2c1C(Nc(cncc1)c1N1CCCCC1)=O Chemical compound Nc1n[n](cccc2)c2c1C(Nc(cncc1)c1N1CCCCC1)=O VOTOWVOBHDEJEB-UHFFFAOYSA-N 0.000 description 2
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2013/073482 WO2015084384A1 (en) | 2013-12-06 | 2013-12-06 | Compounds useful as inhibitors of atr kinase |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016540773A JP2016540773A (ja) | 2016-12-28 |
| JP2016540773A5 true JP2016540773A5 (https=) | 2017-02-09 |
Family
ID=49877037
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016536710A Pending JP2016540773A (ja) | 2013-12-06 | 2013-12-06 | Ａｔｒキナーゼの阻害剤として有用な化合物 |
Country Status (3)
| Country | Link |
|---|---|
| EP (1) | EP3077393A1 (https=) |
| JP (1) | JP2016540773A (https=) |
| WO (1) | WO2015084384A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201516504D0 (en) | 2015-09-17 | 2015-11-04 | Astrazeneca Ab | Imadazo(4,5-c)quinolin-2-one Compounds and their use in treating cancer |
| HK1258570A1 (zh) | 2015-09-30 | 2019-11-15 | Vertex Pharmaceuticals Inc. | 使用dna损伤剂及atr抑制剂的组合治疗癌症的方法 |
| EP3461480A1 (en) | 2017-09-27 | 2019-04-03 | Onxeo | Combination of a dna damage response cell cycle checkpoint inhibitors and belinostat for treating cancer |
| WO2020064971A1 (en) | 2018-09-26 | 2020-04-02 | Merck Patent Gmbh | Combination of a pd-1 antagonist, an atr inhibitor and a platinating agent for the treatment of cancer |
| EP3866785A1 (en) | 2018-10-15 | 2021-08-25 | Merck Patent GmbH | Combination therapy utilizing dna alkylating agents and atr inhibitors |
| EP4230628B1 (en) | 2020-10-16 | 2025-10-15 | Shanghai de Novo Pharmatech Co., Ltd. | Triheterocyclic derivative, and pharmaceutical composition and application thereof |
| CN115466258A (zh) * | 2021-06-11 | 2022-12-13 | 成都苑东生物制药股份有限公司 | Atr抑制剂及其用途 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20080538A1 (es) * | 2006-08-04 | 2008-06-18 | Takeda Pharmaceutical | Derivado heterociclico fusionado y su uso |
| UA110324C2 (en) * | 2009-07-02 | 2015-12-25 | Genentech Inc | Jak inhibitory compounds based on pyrazolo pyrimidine |
| WO2012100342A1 (en) * | 2011-01-27 | 2012-08-02 | Université de Montréal | Pyrazolopyridine and pyrazolopyrimidine derivatives as melanocortin-4 receptor modulators |
-
2013
- 2013-12-06 JP JP2016536710A patent/JP2016540773A/ja active Pending
- 2013-12-06 EP EP13811718.9A patent/EP3077393A1/en not_active Withdrawn
- 2013-12-06 WO PCT/US2013/073482 patent/WO2015084384A1/en not_active Ceased
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