JP2016540051A5 - - Google Patents
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- JP2016540051A5 JP2016540051A5 JP2016556693A JP2016556693A JP2016540051A5 JP 2016540051 A5 JP2016540051 A5 JP 2016540051A5 JP 2016556693 A JP2016556693 A JP 2016556693A JP 2016556693 A JP2016556693 A JP 2016556693A JP 2016540051 A5 JP2016540051 A5 JP 2016540051A5
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- JP
- Japan
- Prior art keywords
- ring
- alkyl
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- group
- compound
- Prior art date
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- 150000001875 compounds Chemical class 0.000 claims 33
- 125000000217 alkyl group Chemical group 0.000 claims 18
- 150000001204 N-oxides Chemical class 0.000 claims 10
- 229910052736 halogen Inorganic materials 0.000 claims 10
- 150000002367 halogens Chemical class 0.000 claims 10
- 150000003839 salts Chemical class 0.000 claims 10
- 125000003118 aryl group Chemical group 0.000 claims 9
- 239000012453 solvate Substances 0.000 claims 9
- 125000001072 heteroaryl group Chemical group 0.000 claims 7
- 125000006648 (C1-C8) haloalkyl group Chemical group 0.000 claims 6
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 6
- 125000003342 alkenyl group Chemical group 0.000 claims 6
- 125000000304 alkynyl group Chemical group 0.000 claims 6
- 229910052799 carbon Inorganic materials 0.000 claims 6
- UHOVQNZJYSORNB-UHFFFAOYSA-N monobenzene Natural products C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 claims 5
- 125000001424 substituent group Chemical group 0.000 claims 5
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 claims 4
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 4
- 125000003545 alkoxy group Chemical group 0.000 claims 4
- 150000001732 carboxylic acid derivatives Chemical group 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 4
- 229910052757 nitrogen Inorganic materials 0.000 claims 4
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 4
- 229920006395 saturated elastomer Polymers 0.000 claims 4
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims 3
- 229910052760 oxygen Inorganic materials 0.000 claims 3
- 229910052717 sulfur Inorganic materials 0.000 claims 3
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 2
- SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical group N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 claims 2
- 125000003282 alkyl amino group Chemical group 0.000 claims 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- 125000005842 heteroatom Chemical group 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Chemical group COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims 2
- 102100025074 C-C chemokine receptor-like 2 Human genes 0.000 claims 1
- 206010012438 Dermatitis atopic Diseases 0.000 claims 1
- 101000716068 Homo sapiens C-C chemokine receptor type 6 Proteins 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical group C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 claims 1
- 201000008937 atopic dermatitis Diseases 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 150000003536 tetrazoles Chemical class 0.000 claims 1
- 0 C[C@@](*)c1cc(*)ccc1C(N)=* Chemical compound C[C@@](*)c1cc(*)ccc1C(N)=* 0.000 description 13
- SGCNOJRXWAOWPL-UHFFFAOYSA-N CC(C)(C)c(ccc(C)c1)c1F Chemical compound CC(C)(C)c(ccc(C)c1)c1F SGCNOJRXWAOWPL-UHFFFAOYSA-N 0.000 description 2
- OGVXDHCMSPOEMS-UHFFFAOYSA-N CC(C)(C)c(c(F)c1)ccc1S(Nc(cc(c(O1)c2)OC1(F)F)c2-c1ccc(C(O)=O)c2c1cccn2)=O Chemical compound CC(C)(C)c(c(F)c1)ccc1S(Nc(cc(c(O1)c2)OC1(F)F)c2-c1ccc(C(O)=O)c2c1cccn2)=O OGVXDHCMSPOEMS-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361910838P | 2013-12-02 | 2013-12-02 | |
| US61/910,838 | 2013-12-02 | ||
| PCT/US2014/068152 WO2015084842A1 (en) | 2013-12-02 | 2014-12-02 | Ccr6 compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016540051A JP2016540051A (ja) | 2016-12-22 |
| JP2016540051A5 true JP2016540051A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 2018-01-18 |
| JP6563947B2 JP6563947B2 (ja) | 2019-08-21 |
Family
ID=53274030
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016556693A Active JP6563947B2 (ja) | 2013-12-02 | 2014-12-02 | Ｃｃｒ６化合物 |
Country Status (13)
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015084842A1 (en) | 2013-12-02 | 2015-06-11 | Chemocentryx, Inc. | Ccr6 compounds |
| WO2019036374A1 (en) | 2017-08-14 | 2019-02-21 | Allergan, Inc. | 3,4-DISUBSTITUTED 3-CYCLOBUTENE-1,2-DIONES AND THEIR USE |
| KR20250103804A (ko) | 2018-03-08 | 2025-07-07 | 인사이트 코포레이션 | PI3K-γ 저해제로서의 아미노피라진 다이올 화합물 |
| US11046658B2 (en) | 2018-07-02 | 2021-06-29 | Incyte Corporation | Aminopyrazine derivatives as PI3K-γ inhibitors |
| JP7449283B2 (ja) | 2018-10-23 | 2024-03-13 | 第一三共株式会社 | ビアリール誘導体 |
| CN117018202A (zh) * | 2019-07-08 | 2023-11-10 | 上海交通大学医学院附属瑞金医院 | 趋化因子受体ccr6抑制剂在预防银屑病复发中的新应用 |
| AU2020310897B2 (en) | 2019-07-10 | 2025-07-17 | Chemocentryx, Inc. | Indanes as PD-L1 inhibitors |
| PH12022550877A1 (en) | 2019-10-16 | 2023-03-27 | Chemocentryx Inc | Heteroaryl-biphenyl amines for the treatment of pd-l1 diseases |
| WO2021076691A1 (en) | 2019-10-16 | 2021-04-22 | Chemocentryx, Inc. | Heteroaryl-biphenyl amides for the treatment of pd-l1 diseases |
| CA3177335A1 (en) | 2020-04-30 | 2021-11-04 | Oliver Allemann | Azetidin-3-ylmethanol derivatives as ccr6 receptor modulators |
| WO2023023534A2 (en) * | 2021-08-18 | 2023-02-23 | Chemocentryx, Inc. | Aryl sulfonyl compounds as ccr6 inhibitors |
| KR20240049280A (ko) | 2021-08-18 | 2024-04-16 | 케모센트릭스, 인크. | Ccr6 억제제로서의 아릴 설포닐(하이드록시) 피페리딘 |
| WO2023057548A1 (en) | 2021-10-07 | 2023-04-13 | Idorsia Pharmaceuticals Ltd | Ccr6 receptor modulators |
| WO2023072924A1 (en) | 2021-10-26 | 2023-05-04 | Idorsia Pharmaceuticals Ltd | Ccr6 receptor modulators |
| TW202325271A (zh) | 2021-10-28 | 2023-07-01 | 瑞士商愛杜西亞製藥有限公司 | Ccr6受體調節劑 |
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| US3944553A (en) | 1974-02-13 | 1976-03-16 | Trw Inc. | Bis quinoline peri acids |
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| EP2474532A1 (en) * | 2005-01-14 | 2012-07-11 | ChemoCentryx, Inc. | Heteroaryl sulfonamides and CCR2 |
| EP2049515B1 (en) * | 2006-07-14 | 2011-01-26 | ChemoCentryx, Inc. | Triazolyl pyridyl benzenesulfonamides as ccr2 or ccr9 modulators for the treatment of atherosclerosis |
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| KR101849560B1 (ko) * | 2007-07-12 | 2018-04-17 | 케모센트릭스, 인크. | 염증의 치료를 위한 ｃｃｒ2 조절물질로서 융합된 헤테로아릴 피리딜과 페닐 벤젠술폰아마이드 |
| NZ582942A (en) * | 2007-08-01 | 2011-09-30 | Lundbeck & Co As H | Use of kncq potassium channel openers for treating attention deficit hyperactivity disorder (adhd) or aggression |
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| TWI487486B (zh) | 2009-12-01 | 2015-06-11 | Syngenta Participations Ag | 以異唑啉衍生物為主之殺蟲化合物 |
| EP2549875B1 (en) | 2010-03-25 | 2015-05-13 | Merck Sharp & Dohme Corp. | Soluble guanylate cyclase activators |
| US9597325B2 (en) | 2010-10-13 | 2017-03-21 | Trustees Of Boston University | Inhibitors of late SV40 factor (LSF) as cancer chemotherapeutics |
| KR101985184B1 (ko) | 2011-01-28 | 2019-06-03 | 주식회사 동진쎄미켐 | 신규한 유기염료 및 이의 제조방법 |
| TW201311149A (zh) | 2011-06-24 | 2013-03-16 | Ishihara Sangyo Kaisha | 有害生物防治劑 |
| CN103781356A (zh) | 2011-08-25 | 2014-05-07 | 先正达参股股份有限公司 | 作为杀虫化合物的异噁唑啉衍生物 |
| FR2981935B1 (fr) | 2011-10-28 | 2015-08-07 | Galderma Res & Dev | Nouveaux composes di-substitues de la diamino-3,4-cyclobutene-3-dione-1,2 utiles dans le traitement de pathologies mediees par des chimiokines. |
| FR2981934B1 (fr) * | 2011-10-28 | 2013-12-20 | Galderma Res & Dev | Nouveaux composes di-substitues de la diamino-3,4-cyclobutene-3-dione-1,2 utiles dans le traitement de pathologies mediees par des chimiokines. |
| CN104520288B (zh) * | 2012-02-29 | 2017-05-17 | 坎莫森特里克斯公司 | 作为ccr9拮抗剂的吡唑‑1‑基苯磺酰胺 |
| WO2015084842A1 (en) | 2013-12-02 | 2015-06-11 | Chemocentryx, Inc. | Ccr6 compounds |
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2014
- 2014-12-02 WO PCT/US2014/068152 patent/WO2015084842A1/en active Application Filing
- 2014-12-02 ES ES14867718T patent/ES2735360T3/es active Active
- 2014-12-02 CN CN201480065637.7A patent/CN105960237B/zh active Active
- 2014-12-02 EP EP14867718.0A patent/EP3076968B1/en active Active
- 2014-12-02 KR KR1020167017459A patent/KR102331833B1/ko active Active
- 2014-12-02 JP JP2016556693A patent/JP6563947B2/ja active Active
- 2014-12-02 CA CA2930148A patent/CA2930148C/en active Active
- 2014-12-02 MX MX2016007128A patent/MX2016007128A/es active IP Right Grant
- 2014-12-02 US US14/557,949 patent/US9340509B2/en active Active
- 2014-12-02 AU AU2014360743A patent/AU2014360743C1/en active Active
- 2014-12-02 EA EA201691141A patent/EA029826B1/ru not_active IP Right Cessation
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2016
- 2016-03-18 US US15/074,965 patent/US9795599B2/en active Active
- 2016-05-11 ZA ZA2016/03167A patent/ZA201603167B/en unknown
- 2016-05-18 IL IL24570416A patent/IL245704B/en active IP Right Grant
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2017
- 2017-09-19 US US15/709,012 patent/US10117865B2/en active Active
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2018
- 2018-10-03 US US16/150,796 patent/US10786494B2/en active Active