JP2016535049A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2016535049A5 JP2016535049A5 JP2016527342A JP2016527342A JP2016535049A5 JP 2016535049 A5 JP2016535049 A5 JP 2016535049A5 JP 2016527342 A JP2016527342 A JP 2016527342A JP 2016527342 A JP2016527342 A JP 2016527342A JP 2016535049 A5 JP2016535049 A5 JP 2016535049A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- alkyl
- groups
- optionally substituted
- cycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229910052739 hydrogen Inorganic materials 0.000 claims description 24
- 125000000623 heterocyclic group Chemical group 0.000 claims description 18
- 125000003386 piperidinyl group Chemical group 0.000 claims description 18
- -1 or one NR N ′′ Inorganic materials 0.000 claims description 14
- 150000003839 salts Chemical class 0.000 claims description 13
- 150000001875 compounds Chemical class 0.000 claims description 12
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims description 11
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims description 11
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims description 10
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims description 9
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 claims description 9
- 125000001412 tetrahydropyranyl group Chemical group 0.000 claims description 9
- 125000002950 monocyclic group Chemical group 0.000 claims description 8
- 229910052717 sulfur Inorganic materials 0.000 claims description 8
- 125000002619 bicyclic group Chemical group 0.000 claims description 7
- 229910052760 oxygen Inorganic materials 0.000 claims description 7
- 229920006395 saturated elastomer Polymers 0.000 claims description 7
- 125000002393 azetidinyl group Chemical group 0.000 claims description 6
- 229910052731 fluorine Inorganic materials 0.000 claims description 6
- 229910052799 carbon Inorganic materials 0.000 claims description 5
- 125000004432 carbon atom Chemical group C* 0.000 claims description 5
- 125000004122 cyclic group Chemical group 0.000 claims description 5
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 5
- 229910052801 chlorine Inorganic materials 0.000 claims description 4
- 125000005842 heteroatom Chemical group 0.000 claims description 4
- 125000002757 morpholinyl group Chemical group 0.000 claims description 4
- 229910052794 bromium Inorganic materials 0.000 claims description 3
- 125000004429 atom Chemical group 0.000 claims description 2
- 229910052740 iodine Inorganic materials 0.000 claims description 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 7
- 239000008194 pharmaceutical composition Substances 0.000 claims 7
- 125000000217 alkyl group Chemical group 0.000 claims 5
- 102000014156 AMP-Activated Protein Kinases Human genes 0.000 claims 4
- 108010011376 AMP-Activated Protein Kinases Proteins 0.000 claims 4
- 125000001072 heteroaryl group Chemical group 0.000 claims 4
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 3
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims 3
- 125000003118 aryl group Chemical group 0.000 claims 3
- 125000000732 arylene group Chemical group 0.000 claims 3
- 125000004976 cyclobutylene group Chemical group 0.000 claims 3
- 125000004956 cyclohexylene group Chemical group 0.000 claims 3
- 125000004979 cyclopentylene group Chemical group 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000016097 disease of metabolism Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 125000005549 heteroarylene group Chemical group 0.000 claims 3
- 125000006588 heterocycloalkylene group Chemical group 0.000 claims 3
- 208000030159 metabolic disease Diseases 0.000 claims 3
- WQGWDDDVZFFDIG-UHFFFAOYSA-N pyrogallol Chemical compound OC1=CC=CC(O)=C1O WQGWDDDVZFFDIG-UHFFFAOYSA-N 0.000 claims 3
- 208000024891 symptom Diseases 0.000 claims 3
- 229940124597 therapeutic agent Drugs 0.000 claims 3
- 208000008589 Obesity Diseases 0.000 claims 2
- 239000003472 antidiabetic agent Substances 0.000 claims 2
- 239000000969 carrier Substances 0.000 claims 2
- 125000005724 cycloalkenylene group Chemical group 0.000 claims 2
- 125000002993 cycloalkylene group Chemical group 0.000 claims 2
- 125000005725 cyclohexenylene group Chemical group 0.000 claims 2
- 239000003085 diluting agent Substances 0.000 claims 2
- 235000020824 obesity Nutrition 0.000 claims 2
- 125000003003 spiro group Chemical group 0.000 claims 2
- 125000006376 (C3-C10) cycloalkyl group Chemical group 0.000 claims 1
- 125000001054 5 membered carbocyclic group Chemical group 0.000 claims 1
- 125000004008 6 membered carbocyclic group Chemical group 0.000 claims 1
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- 208000024172 Cardiovascular disease Diseases 0.000 claims 1
- 208000032928 Dyslipidaemia Diseases 0.000 claims 1
- 206010019280 Heart failures Diseases 0.000 claims 1
- 206010020772 Hypertension Diseases 0.000 claims 1
- 206010022489 Insulin Resistance Diseases 0.000 claims 1
- 208000017170 Lipid metabolism disease Diseases 0.000 claims 1
- 229940127003 anti-diabetic drug Drugs 0.000 claims 1
- 229940125708 antidiabetic agent Drugs 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 125000004430 oxygen atom Chemical group O* 0.000 claims 1
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 claims 1
- 125000005551 pyridylene group Chemical group 0.000 claims 1
- 125000005717 substituted cycloalkylene group Chemical group 0.000 claims 1
- 125000003831 tetrazolyl group Chemical group 0.000 claims 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 description 13
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 description 4
- 0 *C1COCC1 Chemical compound *C1COCC1 0.000 description 3
- 239000002253 acid Substances 0.000 description 2
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 2
- 125000001183 hydrocarbyl group Chemical group 0.000 description 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 description 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 description 1
- AHVQYHFYQWKUKB-UHFFFAOYSA-N NC1CCOCC1 Chemical compound NC1CCOCC1 AHVQYHFYQWKUKB-UHFFFAOYSA-N 0.000 description 1
- DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical class OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 125000002015 acyclic group Chemical group 0.000 description 1
- 125000005073 adamantyl group Chemical group C12(CC3CC(CC(C1)C3)C2)* 0.000 description 1
- 125000003725 azepanyl group Chemical group 0.000 description 1
- 125000004069 aziridinyl group Chemical group 0.000 description 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 1
- 239000000460 chlorine Substances 0.000 description 1
- 125000000582 cycloheptyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 1
- 125000006547 cyclononyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 description 1
- 125000000640 cyclooctyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 description 1
- 239000011737 fluorine Substances 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 150000002367 halogens Chemical class 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 125000002868 norbornyl group Chemical group C12(CCC(CC1)C2)* 0.000 description 1
- 125000005482 norpinyl group Chemical group 0.000 description 1
- 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000003566 oxetanyl group Chemical group 0.000 description 1
- 125000000466 oxiranyl group Chemical group 0.000 description 1
- 125000004193 piperazinyl group Chemical group 0.000 description 1
- 125000002873 tetrahydrofuranonyl group Chemical group 0.000 description 1
- 125000002673 tetrahydropyranonyl group Chemical group O1C(C(CCC1)*)=O 0.000 description 1
- 125000004568 thiomorpholinyl group Chemical group 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13191195.0 | 2013-10-31 | ||
| EP13191195 | 2013-10-31 | ||
| PCT/EP2014/072959 WO2015063011A1 (en) | 2013-10-31 | 2014-10-27 | Azabenzimidazole derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016535049A JP2016535049A (ja) | 2016-11-10 |
| JP2016535049A5 true JP2016535049A5 (cg-RX-API-DMAC7.html) | 2017-12-14 |
| JP6474804B2 JP6474804B2 (ja) | 2019-02-27 |
Family
ID=49488531
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016527342A Active JP6474804B2 (ja) | 2013-10-31 | 2014-10-27 | アザベンゾイミダゾール誘導体 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US9187477B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3063148B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP6474804B2 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2015063011A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2959293A1 (en) | 2014-08-27 | 2016-03-03 | Shionogi & Co., Ltd. | Azaindole derivative having ampk-activating effect |
| CA2965781A1 (en) | 2014-10-28 | 2016-05-06 | Shionogi & Co., Ltd. | Heterocyclic derivative having ampk activating effect |
| US10478425B2 (en) | 2016-02-26 | 2019-11-19 | Shionogi & Co., Ltd. | 5-phenylazaindole derivative having AMPK-activating activity |
| EP3459949A4 (en) * | 2016-05-20 | 2020-04-08 | Shionogi & Co., Ltd | 5-SUBSTITUTED BENZIMIDAZOLE DERIVATIVE AND 5-SUBSTITUTED AZABENZIMIDAZOLE DERIVATIVE WITH AMPK ACTIVATION EFFECT |
| CA3178994A1 (en) | 2020-05-19 | 2021-11-25 | Iyassu Sebhat | Ampk activators |
| WO2021263039A1 (en) | 2020-06-26 | 2021-12-30 | Kallyope, Inc. | Ampk activators |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3243385B1 (en) * | 2011-02-25 | 2021-01-13 | Merck Sharp & Dohme Corp. | Novel cyclic azabenzimidazole derivatives useful as anti-diabetic agents |
| US9567330B2 (en) | 2011-07-15 | 2017-02-14 | Shionogi & Co., Ltd. | Azabenzimidazole derivative having AMPK-activating activity |
| WO2014031465A1 (en) * | 2012-08-22 | 2014-02-27 | Merck Sharp & Dohme Corp. | Novel azabenzimidazole tetrahydropyran derivatives |
-
2014
- 2014-10-27 EP EP14789561.9A patent/EP3063148B1/en active Active
- 2014-10-27 WO PCT/EP2014/072959 patent/WO2015063011A1/en not_active Ceased
- 2014-10-27 JP JP2016527342A patent/JP6474804B2/ja active Active
- 2014-10-28 US US14/525,950 patent/US9187477B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2016535049A5 (cg-RX-API-DMAC7.html) | ||
| JP2016527223A5 (cg-RX-API-DMAC7.html) | ||
| CA2545427C (en) | Selective kinase inhibitors | |
| JP2016508506A5 (cg-RX-API-DMAC7.html) | ||
| JP2015523339A5 (cg-RX-API-DMAC7.html) | ||
| JP2015532295A5 (cg-RX-API-DMAC7.html) | ||
| AU2013216885B2 (en) | Modulators of exchange proteins directly activated by cAMP (EPACs) | |
| JP2017523226A5 (cg-RX-API-DMAC7.html) | ||
| AU2014206036B2 (en) | Fluorinated CBD compounds, compositions and uses thereof | |
| JP2014524424A (ja) | Ｎ１−環状アミン−ｎ５−置換フェニルビグアニド誘導体、それの調製方法及びそれを含む医薬組成物 | |
| CN105209036B (zh) | 氧杂双环庚烷和氧杂双环庚烯的配制品 | |
| JP2016509047A5 (cg-RX-API-DMAC7.html) | ||
| JP2015512942A5 (cg-RX-API-DMAC7.html) | ||
| JP2006514098A5 (cg-RX-API-DMAC7.html) | ||
| JP2012520861A5 (cg-RX-API-DMAC7.html) | ||
| AR044762A1 (es) | Derivados de ester y amida del acido 2-cianopropanoico, un proceso para su preparacion y el uso de dichos derivados para la preparacion de un medicamento | |
| JP2016534084A5 (cg-RX-API-DMAC7.html) | ||
| JP2013501008A (ja) | 抗ウイルス性化合物ならびにそれを含む医薬組成物 | |
| JP2016534037A5 (cg-RX-API-DMAC7.html) | ||
| AR032592A1 (es) | Aminoalcoxicarbazoles y el uso de los mismos para la manufactura de un medicamento para el tratamiento de enfermedades del snc | |
| CN103450112B (zh) | 一种n-桥连接的含氮五元杂环化合物及其制备与用途 | |
| TW201726637A (zh) | 對電位閘控鈉通道具選擇活性之羥基烷基胺－及羥基環烷基胺－取代之二胺－芳基磺胺化合物 | |
| CN102137846B (zh) | N-(2-氨基苯基)-4-[n-(吡啶-3-基)甲氧基羰基氨基甲基]苯甲酰胺(ms-275)多晶型物b | |
| JP2019535792A5 (cg-RX-API-DMAC7.html) | ||
| JP2016540795A (ja) | エーテル側鎖を有するキラルなｎ−置換イミダゾールカルボキシルエステル化合物、その製造方法及び用途 |