JP2016534094A5 - - Google Patents
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- Publication number
- JP2016534094A5 JP2016534094A5 JP2016530087A JP2016530087A JP2016534094A5 JP 2016534094 A5 JP2016534094 A5 JP 2016534094A5 JP 2016530087 A JP2016530087 A JP 2016530087A JP 2016530087 A JP2016530087 A JP 2016530087A JP 2016534094 A5 JP2016534094 A5 JP 2016534094A5
- Authority
- JP
- Japan
- Prior art keywords
- average diameter
- nanoscale construct
- nanoscale
- nucleic acid
- antagonist
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361858584P | 2013-07-25 | 2013-07-25 | |
| US61/858,584 | 2013-07-25 | ||
| PCT/US2014/048294 WO2015013675A1 (en) | 2013-07-25 | 2014-07-25 | Spherical nucleic acid-based constructs as immunoregulatory agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016534094A JP2016534094A (ja) | 2016-11-04 |
| JP2016534094A5 true JP2016534094A5 (https=) | 2017-09-07 |
Family
ID=51422128
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016530087A Pending JP2016534094A (ja) | 2013-07-25 | 2014-07-25 | 免疫調節剤としての球状核酸に基づくコンストラクト |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20160194642A1 (https=) |
| EP (1) | EP3024494A1 (https=) |
| JP (1) | JP2016534094A (https=) |
| KR (1) | KR20160045726A (https=) |
| CN (1) | CN105658241A (https=) |
| AU (1) | AU2014292928A1 (https=) |
| CA (1) | CA2919273A1 (https=) |
| WO (1) | WO2015013675A1 (https=) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100233270A1 (en) | 2009-01-08 | 2010-09-16 | Northwestern University | Delivery of Oligonucleotide-Functionalized Nanoparticles |
| WO2011091065A2 (en) | 2010-01-19 | 2011-07-28 | Northwestern University | Synthetic nanostructures including nucleic acids and/or other entities |
| CN105579582A (zh) | 2013-07-25 | 2016-05-11 | 埃克西奎雷股份有限公司 | 用于预防和治疗用途的作为免疫刺激剂的基于球形核酸的构建体 |
| WO2015023797A1 (en) | 2013-08-13 | 2015-02-19 | Northwestern University | Lipophilic nanoparticles for drug delivery |
| JP6527516B2 (ja) | 2013-12-03 | 2019-06-05 | ノースウェスタン ユニバーシティ | リポソーム粒子、前述のものを作製する方法及びその使用 |
| US10413565B2 (en) | 2014-04-30 | 2019-09-17 | Northwestern University | Nanostructures for modulating intercellular communication and uses thereof |
| AU2015269412B2 (en) | 2014-06-04 | 2020-03-12 | Exicure Operating Company | Multivalent delivery of immune modulators by liposomal spherical nucleic acids for prophylactic or therapeutic applications |
| CA2963931A1 (en) | 2014-10-06 | 2016-04-14 | Exicure, Inc. | Anti-tnf compounds |
| KR20170078843A (ko) | 2014-11-21 | 2017-07-07 | 노오쓰웨스턴 유니버시티 | 구형 핵산 나노입자 접합체의 서열 특이적 세포 흡수 |
| WO2016085986A1 (en) | 2014-11-24 | 2016-06-02 | Northwestern University | High density lipoprptein nanoparticles for inflammation |
| WO2016115320A1 (en) * | 2015-01-14 | 2016-07-21 | Exicure, Inc. | Nucleic acid nanostructructures with core motifs |
| WO2016134104A1 (en) * | 2015-02-18 | 2016-08-25 | Exicure, Inc. | Immuno-regulatory lipid containing spherical nucleic acids |
| WO2016149323A1 (en) * | 2015-03-16 | 2016-09-22 | Exicure, Inc. | Immunomodulatory spherical nucleic acids |
| US10078092B2 (en) | 2015-03-18 | 2018-09-18 | Northwestern University | Assays for measuring binding kinetics and binding capacity of acceptors for lipophilic or amphiphilic molecules |
| US20180214376A1 (en) * | 2015-07-14 | 2018-08-02 | Exicure, Inc. | Spherical nucleic acid (sna)-mediated delivery of lipid-complexes to cells |
| EP3452598A4 (en) * | 2016-05-06 | 2020-04-29 | Exicure, Inc. | LIPOSOMAL SPHERICAL NUCLEIC ACID (ANS) CONSTRUCTS HAVING ANTISENSE OLIGONUCLEOTIDES (ASO) FOR THE SPECIFIC INACTIVATION OF INTERLEUKIN 17 RECEPTOR RNA |
| US11364304B2 (en) | 2016-08-25 | 2022-06-21 | Northwestern University | Crosslinked micellar spherical nucleic acids |
| US11696954B2 (en) | 2017-04-28 | 2023-07-11 | Exicure Operating Company | Synthesis of spherical nucleic acids using lipophilic moieties |
| US20200291394A1 (en) * | 2017-05-17 | 2020-09-17 | Northwestern University | Conjugation of peptides to spherical nucleic acids (snas) using traceless linkers |
| JP2020526558A (ja) | 2017-07-13 | 2020-08-31 | ノースウェスタン ユニバーシティ | オリゴヌクレオチド官能化金属有機構造体ナノ粒子を調製するための一般的かつ直接的な方法 |
| JP7023460B2 (ja) * | 2017-10-26 | 2022-02-22 | 国立大学法人 鹿児島大学 | Ｔｌｒリガンド固定化ナノ粒子 |
| WO2019217870A1 (en) * | 2018-05-10 | 2019-11-14 | Northwestern University | Self-manageable abnormal scar treatment with spherical nucleic acid (sna) technology |
| WO2019246409A1 (en) * | 2018-06-20 | 2019-12-26 | Exicure, Inc. | Il-1 beta targeting spherical nucleic acids |
| US12319711B2 (en) | 2019-09-20 | 2025-06-03 | Northwestern University | Spherical nucleic acids with tailored and active protein coronae |
| US12378560B2 (en) | 2019-10-29 | 2025-08-05 | Northwestern University | Sequence multiplicity within spherical nucleic acids |
| US11951211B2 (en) * | 2020-01-31 | 2024-04-09 | Yale University | DNA brick-assisted liposome sorting |
| EP4630561A1 (en) * | 2022-12-09 | 2025-10-15 | Takeda Pharmaceutical Company Limited | Modified immunomodulators |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5472881A (en) | 1992-11-12 | 1995-12-05 | University Of Utah Research Foundation | Thiol labeling of DNA for attachment to gold surfaces |
| US6750016B2 (en) | 1996-07-29 | 2004-06-15 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses therefor |
| ES2287956T3 (es) | 1996-07-29 | 2007-12-16 | Nanosphere Inc. | Nanoparticulas que tienen oligonucleotidos unidos a las mismas y usos de las mismas. |
| US6361944B1 (en) | 1996-07-29 | 2002-03-26 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses therefor |
| US5849902A (en) | 1996-09-26 | 1998-12-15 | Oligos Etc. Inc. | Three component chimeric antisense oligonucleotides |
| US6506569B1 (en) | 1997-05-30 | 2003-01-14 | Human Genome Sciences, Inc. | Antibodies to human tumor necrosis factor receptor TR10 |
| DE60045739D1 (de) | 1999-06-25 | 2011-04-28 | Nanosphere Inc | Nanopartikel mit gebundenen oligonukleotiden und deren verwendungen |
| AU774593C (en) | 2000-01-13 | 2005-06-23 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses therefor |
| JP2004515208A (ja) | 2000-03-28 | 2004-05-27 | ナノスフェアー インコーポレイテッド | オリゴヌクレオチドを付着させたナノ粒子とその使用方法 |
| US7238472B2 (en) | 2001-05-25 | 2007-07-03 | Nanosphere, Inc. | Non-alloying core shell nanoparticles |
| ES2304467T3 (es) | 2001-07-10 | 2008-10-16 | North Carolina State University | Vehiculo de liberacion de nanoparticulas. |
| WO2006138145A1 (en) | 2005-06-14 | 2006-12-28 | Northwestern University | Nucleic acid functionalized nanoparticles for therapeutic applications |
| US8507200B2 (en) | 2007-02-09 | 2013-08-13 | Northwestern University | Particles for detecting intracellular targets |
| WO2008127789A2 (en) | 2007-02-27 | 2008-10-23 | Northwestern University | Molecule attachment to nanoparticles |
| DK2160464T3 (da) | 2007-05-30 | 2014-08-04 | Univ Northwestern | Nukleinsyrefunktionaliserede nanopartikler til terapeutiske anvendelser |
| WO2010014572A2 (en) * | 2008-07-28 | 2010-02-04 | Idera Pharmaceuticals, Inc. | Modulation of toll-like receptor 9 expression by antisense oligonucleotides |
| CN106955360A (zh) | 2008-11-24 | 2017-07-18 | 西北大学 | 多价rna纳米颗粒组合物 |
| US20100233270A1 (en) | 2009-01-08 | 2010-09-16 | Northwestern University | Delivery of Oligonucleotide-Functionalized Nanoparticles |
| WO2010081049A1 (en) | 2009-01-08 | 2010-07-15 | Northwestern University | Inhibition of bacterial protein production by polyvalent oligonucleotide modified nanoparticle conjugates |
| US20100294952A1 (en) | 2009-01-15 | 2010-11-25 | Northwestern University | Controlled agent release and sequestration |
| WO2011017456A2 (en) | 2009-08-04 | 2011-02-10 | Northwestern University | Localized delivery of nanoparticles for therapeutic and diagnostic applications |
| WO2011017690A2 (en) | 2009-08-07 | 2011-02-10 | Northwestern University | Intracellular delivery of contrast agents with functionalized nanoparticles |
| US20110111974A1 (en) | 2009-10-23 | 2011-05-12 | Northwestern University | Short Duplex Probes for Enhanced Target Hybridization |
| DK2494075T3 (en) | 2009-10-30 | 2018-07-23 | Univ Northwestern | TABLE-MANAGED NANOCONJUGATES |
| WO2011079290A1 (en) | 2009-12-24 | 2011-06-30 | Northwestern University | Oligonucleotide specific uptake of nanoconjugates |
| EP2399608B1 (en) * | 2010-03-05 | 2020-07-08 | Sebastian Fuchs | Immunomodulating nanoparticulate composition for use in inhalation therapy |
-
2014
- 2014-07-25 JP JP2016530087A patent/JP2016534094A/ja active Pending
- 2014-07-25 CN CN201480052513.5A patent/CN105658241A/zh active Pending
- 2014-07-25 EP EP14756142.7A patent/EP3024494A1/en not_active Withdrawn
- 2014-07-25 CA CA2919273A patent/CA2919273A1/en not_active Abandoned
- 2014-07-25 AU AU2014292928A patent/AU2014292928A1/en not_active Abandoned
- 2014-07-25 KR KR1020167004851A patent/KR20160045726A/ko not_active Withdrawn
- 2014-07-25 WO PCT/US2014/048294 patent/WO2015013675A1/en not_active Ceased
- 2014-07-25 US US14/907,455 patent/US20160194642A1/en not_active Abandoned
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