JP2016534094A5 - - Google Patents
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- Publication number
- JP2016534094A5 JP2016534094A5 JP2016530087A JP2016530087A JP2016534094A5 JP 2016534094 A5 JP2016534094 A5 JP 2016534094A5 JP 2016530087 A JP2016530087 A JP 2016530087A JP 2016530087 A JP2016530087 A JP 2016530087A JP 2016534094 A5 JP2016534094 A5 JP 2016534094A5
- Authority
- JP
- Japan
- Prior art keywords
- average diameter
- nanoscale construct
- nanoscale
- nucleic acid
- antagonist
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361858584P | 2013-07-25 | 2013-07-25 | |
| US61/858,584 | 2013-07-25 | ||
| PCT/US2014/048294 WO2015013675A1 (en) | 2013-07-25 | 2014-07-25 | Spherical nucleic acid-based constructs as immunoregulatory agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016534094A JP2016534094A (ja) | 2016-11-04 |
| JP2016534094A5 true JP2016534094A5 (https=) | 2017-09-07 |
Family
ID=51422128
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016530087A Pending JP2016534094A (ja) | 2013-07-25 | 2014-07-25 | 免疫調節剤としての球状核酸に基づくコンストラクト |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20160194642A1 (https=) |
| EP (1) | EP3024494A1 (https=) |
| JP (1) | JP2016534094A (https=) |
| KR (1) | KR20160045726A (https=) |
| CN (1) | CN105658241A (https=) |
| AU (1) | AU2014292928A1 (https=) |
| CA (1) | CA2919273A1 (https=) |
| WO (1) | WO2015013675A1 (https=) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100233270A1 (en) | 2009-01-08 | 2010-09-16 | Northwestern University | Delivery of Oligonucleotide-Functionalized Nanoparticles |
| AU2011207563B2 (en) | 2010-01-19 | 2016-03-10 | Northwestern University | Synthetic nanostructures including nucleic acids and/or other entities |
| EP3024936B1 (en) | 2013-07-25 | 2019-09-04 | Exicure, Inc. | Spherical nucleic acid-based constructs as immunostimulatory agents for prophylactic and therapeutic use |
| US10568898B2 (en) | 2013-08-13 | 2020-02-25 | Northwestern University | Lipophilic nanoparticles for drug delivery |
| US10182988B2 (en) * | 2013-12-03 | 2019-01-22 | Northwestern University | Liposomal particles, methods of making same and uses thereof |
| US10413565B2 (en) | 2014-04-30 | 2019-09-17 | Northwestern University | Nanostructures for modulating intercellular communication and uses thereof |
| TR201908550T4 (tr) | 2014-06-04 | 2019-07-22 | Exicure Inc | Profilaktik veya terapötik uygulamalar için lipozomal sferik nükleik asitler tarafından immün modülatörlerin çok değerlikli teslimi. |
| CR20170181A (es) | 2014-10-06 | 2017-05-31 | Exicure Inc | Compuestos anti-tnf |
| US11213593B2 (en) | 2014-11-21 | 2022-01-04 | Northwestern University | Sequence-specific cellular uptake of spherical nucleic acid nanoparticle conjugates |
| US10517924B2 (en) | 2014-11-24 | 2019-12-31 | Northwestern University | High density lipoprotein nanoparticles for inflammation |
| CA2973702A1 (en) * | 2015-01-14 | 2016-07-21 | Exicure, Inc. | Nucleic acid nanostructures with core motifs |
| WO2016134104A1 (en) * | 2015-02-18 | 2016-08-25 | Exicure, Inc. | Immuno-regulatory lipid containing spherical nucleic acids |
| WO2016149323A1 (en) * | 2015-03-16 | 2016-09-22 | Exicure, Inc. | Immunomodulatory spherical nucleic acids |
| US10078092B2 (en) | 2015-03-18 | 2018-09-18 | Northwestern University | Assays for measuring binding kinetics and binding capacity of acceptors for lipophilic or amphiphilic molecules |
| WO2017011662A1 (en) * | 2015-07-14 | 2017-01-19 | Exicure, Inc. | Spherical nucleic acid (sna)-mediated delivery of lipid-complexes to cells |
| EP3452598A4 (en) | 2016-05-06 | 2020-04-29 | Exicure, Inc. | LIPOSOMAL SPHERICAL NUCLEIC ACID (ANS) CONSTRUCTS HAVING ANTISENSE OLIGONUCLEOTIDES (ASO) FOR THE SPECIFIC INACTIVATION OF INTERLEUKIN 17 RECEPTOR RNA |
| WO2018039629A2 (en) | 2016-08-25 | 2018-03-01 | Northwestern University | Micellar spherical nucleic acids from thermoresponsive, traceless templates |
| US11696954B2 (en) | 2017-04-28 | 2023-07-11 | Exicure Operating Company | Synthesis of spherical nucleic acids using lipophilic moieties |
| WO2018213585A1 (en) * | 2017-05-17 | 2018-11-22 | Northwestern University | Conjugation of peptides to spherical nucleic acids (snas) using tracelless linkers |
| MX2020000387A (es) | 2017-07-13 | 2020-08-17 | Univ Northwestern | Método general y directo para preparar nanopartículas de estructura organometálica funcionalizadas con oligonucleotidos. |
| JP7023460B2 (ja) * | 2017-10-26 | 2022-02-22 | 国立大学法人 鹿児島大学 | Ｔｌｒリガンド固定化ナノ粒子 |
| US20210189397A1 (en) * | 2018-05-10 | 2021-06-24 | Northwestern University | Self-manageable abnormal scar treatment with spherical nucleic acid (sna) technology |
| WO2019246409A1 (en) * | 2018-06-20 | 2019-12-26 | Exicure, Inc. | Il-1 beta targeting spherical nucleic acids |
| US12319711B2 (en) | 2019-09-20 | 2025-06-03 | Northwestern University | Spherical nucleic acids with tailored and active protein coronae |
| US12378560B2 (en) | 2019-10-29 | 2025-08-05 | Northwestern University | Sequence multiplicity within spherical nucleic acids |
| US11951211B2 (en) * | 2020-01-31 | 2024-04-09 | Yale University | DNA brick-assisted liposome sorting |
| JP2025540278A (ja) * | 2022-12-09 | 2025-12-11 | 武田薬品工業株式会社 | 修飾免疫調節薬 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5472881A (en) | 1992-11-12 | 1995-12-05 | University Of Utah Research Foundation | Thiol labeling of DNA for attachment to gold surfaces |
| DE69737598T2 (de) | 1996-07-29 | 2007-12-27 | Nanosphere Inc., Skokie | Nanopartikel mit daran angehefteten oligonukleotiden sowie deren verwendungen |
| US6750016B2 (en) | 1996-07-29 | 2004-06-15 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses therefor |
| US6361944B1 (en) | 1996-07-29 | 2002-03-26 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses therefor |
| US5849902A (en) | 1996-09-26 | 1998-12-15 | Oligos Etc. Inc. | Three component chimeric antisense oligonucleotides |
| US6506569B1 (en) | 1997-05-30 | 2003-01-14 | Human Genome Sciences, Inc. | Antibodies to human tumor necrosis factor receptor TR10 |
| WO2001000876A1 (en) | 1999-06-25 | 2001-01-04 | Mirkin Chad A | Nanoparticles having oligonucleotides attached thereto and uses therefor |
| CA2396113C (en) | 2000-01-13 | 2009-04-07 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses therefor |
| CA2402955C (en) | 2000-03-28 | 2010-03-09 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses therefor |
| WO2002096262A2 (en) | 2001-05-25 | 2002-12-05 | Northwestern University | Non-alloying core shell nanoparticles |
| JP2005511761A (ja) | 2001-07-10 | 2005-04-28 | ノース・キャロライナ・ステイト・ユニヴァーシティ | ナノ粒子送達ビヒクル |
| WO2006138145A1 (en) | 2005-06-14 | 2006-12-28 | Northwestern University | Nucleic acid functionalized nanoparticles for therapeutic applications |
| EP2121987B1 (en) | 2007-02-09 | 2012-06-13 | Northwestern University | Particles for detecting intracellular targets |
| CA2679586A1 (en) | 2007-02-27 | 2008-10-23 | Northwestern University | Molecule attachment to nanoparticles |
| EP2160464B1 (en) | 2007-05-30 | 2014-05-21 | Northwestern University | Nucleic acid functionalized nanoparticles for therapeutic applications |
| WO2010014572A2 (en) * | 2008-07-28 | 2010-02-04 | Idera Pharmaceuticals, Inc. | Modulation of toll-like receptor 9 expression by antisense oligonucleotides |
| EP2365803B1 (en) | 2008-11-24 | 2017-11-01 | Northwestern University | Polyvalent rna-nanoparticle compositions |
| AU2010203474B2 (en) | 2009-01-08 | 2015-11-19 | Northwestern University | Inhibition of bacterial protein production by polyvalent oligonucleotide modified nanoparticle conjugates |
| US20100233270A1 (en) | 2009-01-08 | 2010-09-16 | Northwestern University | Delivery of Oligonucleotide-Functionalized Nanoparticles |
| US20100294952A1 (en) | 2009-01-15 | 2010-11-25 | Northwestern University | Controlled agent release and sequestration |
| WO2011017456A2 (en) | 2009-08-04 | 2011-02-10 | Northwestern University | Localized delivery of nanoparticles for therapeutic and diagnostic applications |
| WO2011017690A2 (en) | 2009-08-07 | 2011-02-10 | Northwestern University | Intracellular delivery of contrast agents with functionalized nanoparticles |
| US20110111974A1 (en) | 2009-10-23 | 2011-05-12 | Northwestern University | Short Duplex Probes for Enhanced Target Hybridization |
| CA2779099C (en) | 2009-10-30 | 2021-08-10 | Northwestern University | Templated nanoconjugates |
| WO2011079290A1 (en) | 2009-12-24 | 2011-06-30 | Northwestern University | Oligonucleotide specific uptake of nanoconjugates |
| EP2399608B1 (en) * | 2010-03-05 | 2020-07-08 | Sebastian Fuchs | Immunomodulating nanoparticulate composition for use in inhalation therapy |
-
2014
- 2014-07-25 JP JP2016530087A patent/JP2016534094A/ja active Pending
- 2014-07-25 US US14/907,455 patent/US20160194642A1/en not_active Abandoned
- 2014-07-25 AU AU2014292928A patent/AU2014292928A1/en not_active Abandoned
- 2014-07-25 EP EP14756142.7A patent/EP3024494A1/en not_active Withdrawn
- 2014-07-25 KR KR1020167004851A patent/KR20160045726A/ko not_active Withdrawn
- 2014-07-25 CA CA2919273A patent/CA2919273A1/en not_active Abandoned
- 2014-07-25 WO PCT/US2014/048294 patent/WO2015013675A1/en not_active Ceased
- 2014-07-25 CN CN201480052513.5A patent/CN105658241A/zh active Pending
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